Medeniyet medical journal最新文献

The Lateral Femoral Cutaneous Nerve is at High Risk During Direct Anterior Approach to the Hip Joint Due to Proximity and Anatomic Variations: A Cadaveric Study.

IF 1.1

Medeniyet medical journal Pub Date : 2025-03-28 DOI: 10.4274/MMJ.galenos.2024.47042

Dang Hoang Giang, Thanh Xuan Dao, Du Gia Hoang

{"title":"The Lateral Femoral Cutaneous Nerve is at High Risk During Direct Anterior Approach to the Hip Joint Due to Proximity and Anatomic Variations: A Cadaveric Study.","authors":"Dang Hoang Giang, Thanh Xuan Dao, Du Gia Hoang","doi":"10.4274/MMJ.galenos.2024.47042","DOIUrl":"10.4274/MMJ.galenos.2024.47042","url":null,"abstract":"Objective: In direct anterior approach (DAA) to the hip joint, the risk of lateral femoral cutaneous nerve (LFCN) injury is high. This study on cadavers aimed to identify variations in the anatomy and route of the LFCN and its relationship with the DAA.Methods: The cross-sectional study was conducted on 15 adult formalin-embalmed cadavers [8 males and 7 female (15 paired hips)]. The anterior superior iliac spine, pubic tubercle, and fibular head were used as anatomical reference points.Results: All 30 portals were inserted completely without damage or complications at the anatomical sites. The mean age standard deviation was 72.0 (16.8) range: 26-91 years old. Nineteen nerves crossed the incision. The branching pattern of the lateral cutaneous nerve of the thigh below the inguinal ligament is predominantly fan type (12 nerves, 40.0%), followed by sartorius type (11 nerves, 37.0%), with a lower percentage being posterior type (7 nerves, 23.3%). The average distance from the initial point to the location where the lateral cutaneous nerve of the thigh crosses the surgical incision was 35.3 (16.4-62.9) mm, with a range of 2.3-92.2 mm.Conclusions: The risk of LFCN injury was 50%. Understanding variations in the anatomy and route of the LFCN and its proximity to the incision of the DAA to the hip joint may reduce the risk of injury.","PeriodicalId":37427,"journal":{"name":"Medeniyet medical journal","volume":"40 1","pages":"12-17"},"PeriodicalIF":1.1,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11974468/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143732069","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Biomarkers of the Complement System in Cancer.

IF 1.1

Medeniyet medical journal Pub Date : 2025-03-28 DOI: 10.4274/MMJ.galenos.2025.34783

Elif Kubat Oktem

{"title":"Biomarkers of the Complement System in Cancer.","authors":"Elif Kubat Oktem","doi":"10.4274/MMJ.galenos.2025.34783","DOIUrl":"10.4274/MMJ.galenos.2025.34783","url":null,"abstract":"Objective: Cancer is a disease characterized by an unregulated division of abnormal cells in the body. The discovery of oncogenes and tumor suppressor genes has paved the way for the targeted use of individual biomarkers and proteins in cancer therapy. The signaling pathways in cells are closely linked, and research into these connections would lead to more precise personalized treatments for cancer. An imbalance in the complement system is associated with the development and progression of cancer. Comparable variations in gene expression and common complement biomarkers in different cancer types are poorly understood. This study aims to gain insights into biomarkers linking the complement system to carcinogenesis.Methods: Clinical and transcriptome data from the cancer genome atlas were used to analyze differentially expressed genes involved in the complement system in different cancer types. Various bioinformatics and machine learning techniques were used to suggest complement pathway-related carcinogenesis biomarkers.Results: This study provides a comprehensive elucidation of component 7 (C7), complement factor-D (CFD), interleukin-11 (IL11), apolipoprotein C1 (APOC1), and integrin binding sialic acid protein (IBSP) proteins as common biomarkers associated with the complement system in cancer and highlights the diagnostic and prognostic potential of these biomarkers.Conclusions: These biomarkers would pave the way for targeted cancer treatments in the context of precision medicine.","PeriodicalId":37427,"journal":{"name":"Medeniyet medical journal","volume":"40 1","pages":"1-11"},"PeriodicalIF":1.1,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11974470/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143731957","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Protective Effect of Boric Acid on Oxidative Damage and Cognitive Function in Aging Modeled Rats.

IF 1.1

Medeniyet medical journal Pub Date : 2025-03-28 DOI: 10.4274/MMJ.galenos.2025.22725

Emel Serdaroglu Kasikci, Burcu Cevreli, Feride Nihal Sinan, Zeynep Gurdere, Aylin Sonmez, Rumeysa Sonmez

{"title":"Protective Effect of Boric Acid on Oxidative Damage and Cognitive Function in Aging Modeled Rats.","authors":"Emel Serdaroglu Kasikci, Burcu Cevreli, Feride Nihal Sinan, Zeynep Gurdere, Aylin Sonmez, Rumeysa Sonmez","doi":"10.4274/MMJ.galenos.2025.22725","DOIUrl":"10.4274/MMJ.galenos.2025.22725","url":null,"abstract":"Objective: Aging is a degenerative process. Therefore, the background of our study is to evaluate the effects of boron, one of the important underground resources in Türkiye, on aging and related diseases. This study aimed to assess the antioxidant effect and the cognitive functions of boric acid (BA) in a D-galactose (D-gal)-induced aging model.Methods: Eight male Wistar rats, each 12 weeks old, were split into four groups at random: control, D-gal, BA and D-gal+BA. An experimental aging model was induced by a single subcutaneous injection of D-gal (150 mg/kg/day), and BA (100 mg/kg/day) was administered by oral gavage for 12 weeks. The novel object recognition test (NORT) and Morris water maze (MWM) were used to evaluate the cognitive ability of rats.Results: At the end of the experimental period, glutathione (GSH) and malondialdehyde (MDA) levels were assessed in serum and brain tissue. The treatment of D-gal induced aging rats with BA significantly decreased the MDA level (p<0.05) and increased the GSH level, although the increase was not significant. Moreover, NORT and MWM tests showed that BA significantly improved (p<0.05) cognitive deficits in D-Gal + BA treated rats.Conclusions: BA prevents D-gal-induced memory deficit by decreasing oxidative stress. Hence, BA was a good candidate for addressing age-related neurodegenerative disorders and cognitive function improvements.","PeriodicalId":37427,"journal":{"name":"Medeniyet medical journal","volume":"40 1","pages":"18-25"},"PeriodicalIF":1.1,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11974467/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143731966","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correspondence on Effect of Different Doses of Sugammadex on Recovery and Hemodynamic Parameters in Reversing Neuromuscular Blockade in Patients Undergoing Electroconvulsive Therapy.

IF 1.1

Medeniyet medical journal Pub Date : 2025-03-28 DOI: 10.4274/MMJ.galenos.2025.75570

Ahmet Ridvan Dogan

引用次数: 0

Comment on the "Perivascular Invasion: A Promising Prognostic Parameter for Breast Cancer".

IF 1.1

Medeniyet medical journal Pub Date : 2025-03-28 DOI: 10.4274/MMJ.galenos.2025.81486

Ahmet Bozer

引用次数: 0

Ocular Manifestations of Kaposi Sarcoma: Insights from an HIV-Positive Patient and an Immunocompetent HIV-Negative Patient.

IF 1.1

Medeniyet medical journal Pub Date : 2025-03-28 DOI: 10.4274/MMJ.galenos.2025.37209

Ebubekir Durmus, Esma Ecem Ersoy, Ulviyya Askerova, Fatma Yilmazer

{"title":"Ocular Manifestations of Kaposi Sarcoma: Insights from an HIV-Positive Patient and an Immunocompetent HIV-Negative Patient.","authors":"Ebubekir Durmus, Esma Ecem Ersoy, Ulviyya Askerova, Fatma Yilmazer","doi":"10.4274/MMJ.galenos.2025.37209","DOIUrl":"10.4274/MMJ.galenos.2025.37209","url":null,"abstract":"Kaposi sarcoma (KS) is a vascular neoplasm caused by human herpes virus-8 and is commonly associated with immunocompromised states such as acquired immunodeficiency syndrome. While ocular involvement is rare and typically occurs in human immunodeficiency virus (HIV)-positive patients, it can exceptionally present in HIV-negative, immunocompetent individuals. This report presents two cases of conjunctival KS: One in an HIV-positive patient and another in an HIV-negative patient. The patients were diagnosed and followed up at Istanbul Medeniyet University Göztepe Prof. Dr. Süleyman Yalçın City Hospital. Written informed consent was obtained from the patients for the preparation of this case report. A 35-year-old HIV-positive male with a history of cutaneous and genital KS presented with a painless, reddish, hemorrhagic mass on the left inferior fornix and a firm mass on the lower eyelid. Surgical excision with adjuvant cryotherapy and amniotic membrane transplantation was performed. One year postoperatively, no recurrence or new lesions were observed. A 76-year-old immunocompetent female presented with a painless, progressively enlarging mass in the left inferior fornix. She underwent surgical excision, adjuvant cryotherapy, and amniotic membrane transplantation. Histopathology confirmed the diagnosis of KS, and at the 1-year follow-up, no recurrence or new lesions were observed. Ocular KS, though rare, can occur in both immunocompromised and immunocompetent individuals. This report highlights the importance of considering KS in the differential diagnosis of subconjunctival hemorrhage, even in patients without underlying immunosuppressive conditions. Both cases were successfully managed with surgical excision, adjuvant cryotherapy, and amniotic membrane transplantation, with no recurrence during follow-up.","PeriodicalId":37427,"journal":{"name":"Medeniyet medical journal","volume":"40 1","pages":"26-30"},"PeriodicalIF":1.1,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11974469/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143731964","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Response to the Letter to the Editor Regarding Our Research Article on "Effect of Different Doses of Sugammadex on Recovery and Hemodynamic Parameters in Reversing Neuromuscular Blockade in Patients Undergoing Electroconvulsive Therapy".

IF 1.1

Medeniyet medical journal Pub Date : 2025-03-28 DOI: 10.4274/MMJ.galenos.2025.33667

Kadir Arslan, Ayca Sultan Sahin

引用次数: 0

Response to the Editor Regarding Our Manuscript on "Clinical Characteristics of Children with Acute Poststreptococcal Glomerulonephritis and Re-evaluation of Patients with Artificial Intelligence". 对《儿童急性链球菌感染后肾小球肾炎的临床特点及人工智能患者的再评价》一文编辑的回复

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Medeniyet medical journal Pub Date : 2024-12-27 DOI: 10.4274/MMJ.galenos.2024.02184

Emre Leventoğlu, Mustafa Soran

引用次数: 0

Response to Letter to the Editor on the Manuscript "Posterior Ethmoidal Artery and its Relationship with Anterior Ethmoidal Artery and Skull Base on CT Scan". 关于“筛后动脉及其与筛前动脉与颅底CT扫描关系”稿件致编辑的回复。

IF 1.1

Medeniyet medical journal Pub Date : 2024-12-27 DOI: 10.4274/MMJ.galenos.2024.50951

Thuy Chung Tran Phan, Kiet Vuong Dang

引用次数: 0

The Effect of Intradermal Injection with Two Different Injection Techniques on Pain and Functional Status in Patients with Chronic Nonspecific Neck Pain. 两种不同注射方式皮内注射对慢性非特异性颈部疼痛患者疼痛和功能状态的影响。

IF 1.1

Medeniyet medical journal Pub Date : 2024-12-27 DOI: 10.4274/MMJ.galenos.2024.78972

Sadiye Murat

{"title":"The Effect of Intradermal Injection with Two Different Injection Techniques on Pain and Functional Status in Patients with Chronic Nonspecific Neck Pain.","authors":"Sadiye Murat","doi":"10.4274/MMJ.galenos.2024.78972","DOIUrl":"10.4274/MMJ.galenos.2024.78972","url":null,"abstract":"Objective: This study aimed to compare the effectiveness of different mesotherapy techniques applied at various dermal depths on pain, functional status, and quality of life in patients with non-specific neck pain.Methods: A total of 43 patients who received mesotherapy for non-specific neck pain were retrospectively analyzed. Patients treated with the point-by-point technique (n=21) and the napaj technique (n=22) were recorded. A mixture of 2 mL lidocaine and tenoxicam was used as the mesotherapy solution. Pain was assessed using the visual analog scale (VAS), functional status was assessed using the neck disability index (NDI), and quality of life was assessed using the Nottingham health profile before (T0), after (T1), and 3 months after (T2).Results: In both groups, which were homogeneous in terms of demographic data, statistically significant changes were observed in T1 and T2 values compared with T0 for all evaluation parameters (p=0.001). While both groups demonstrated improvement in all parameters, the posttreatment VAS and NDI score in the point-by-point group was slightly better than that in the napaj group (p=0.042), (p=0.043) but this difference disappeared in the 3-month evaluation.Conclusions: Mesotherapy using a lidocaine-tenoxicam mixture with both the point-by-point and napaj techniques is an effective and safe treatment method for nonspecific neck pain. Both techniques were found to be effective in improving pain, functional status, and quality of life, but neither technique was found to be superior to the other.","PeriodicalId":37427,"journal":{"name":"Medeniyet medical journal","volume":"39 4","pages":"275-282"},"PeriodicalIF":1.1,"publicationDate":"2024-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11683296/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142899003","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0