Medeniyet medical journal最新文献

{"title":"Oleuropein Reduces Secondary Injury Pathways After Experimental Spinal Cord Injury Via HMGB1-Associated Signaling.","authors":"Fatih Çalış, Enes Akkaya, Şevket Evran, Hakan Hanımoğlu, Ebru Gürel Gürevin, Huri Demirci, Serdar Çevik, Abdurrahim Koçyiğit, Elif İlkay Armutak, Osman Behzat Burak Esener, Aziz Hatiboğlu","doi":"10.4274/MMJ.galenos.2026.53293","DOIUrl":"10.4274/MMJ.galenos.2026.53293","url":null,"abstract":"<p><strong>Objective: </strong>Spinal cord injury (SCI) can cause profound disability and substantial morbidity and mortality. Oleuropein (OLE) is a phenolic compound with anti-inflammatory and antioxidant effects. High mobility group box 1 (HMGB1), released extracellularly after tissue injury, can amplify inflammatory signaling. This study investigated the effects of OLE administration following experimental SCI.</p><p><strong>Methods: </strong>Twenty-four female rats were randomly assigned to sham, SCI, and SCI+OLE groups (n=8 each). The sham group underwent T9-T10 laminectomy without SCI. In the SCI and SCI+OLE groups, SCI was induced by 30-second extradural compression with a temporary aneurysm clip. OLE was administered intraperitoneally immediately after injury and again 1 h later. Animals were euthanized 24 h after surgery. Levels of HMGB-1, NF-κB, RAGE, TLR4, and Nrf2 were measured in spinal cord tissue samples by immunohistochemistry and Western blotting. Apoptosis-related protein levels were detected by Western blot. The TUNEL assay was used to quantify apoptotic cells. Oxidative status was assessed using the total oxidant status, the total antioxidant status, and the oxidative stress index.</p><p><strong>Results: </strong>Levels of HMGB1, RAGE, TLR4, and NF-κB increased after SCI, whereas OLE reduced their levels. Nrf2 expression increased after SCI and was further upregulated by OLE. OLE also significantly reduced apoptosis, as evidenced by changes in apoptosis-related protein expression.</p><p><strong>Conclusions: </strong>OLE exerted anti-apoptotic, anti-inflammatory, and antioxidant effects in this experimental SCI model, as demonstrated by analyses of spinal cord tissue and serum.</p>","PeriodicalId":37427,"journal":{"name":"Medeniyet medical journal","volume":"41 3","pages":"285-295"},"PeriodicalIF":1.5,"publicationDate":"2026-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13586905/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148991815","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comment on: \"Central Sensitization and Neuropathic Pain in Hemiplegic Shoulder Pain: A Cross-Sectional Study\".","authors":"Okan Sökmen","doi":"10.4274/MMJ.galenos.2026.92582","DOIUrl":"10.4274/MMJ.galenos.2026.92582","url":null,"abstract":"","PeriodicalId":37427,"journal":{"name":"Medeniyet medical journal","volume":" ","pages":"365-366"},"PeriodicalIF":1.5,"publicationDate":"2026-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13586911/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148799059","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"<i>In Vitro</i> Antifungal Activity of Commonly Used Antiseptics and Disinfectants Against <i>Candida auris</i> Isolates.","authors":"Zafer Habip, Mücahide Esra Koçoğlu, Büşra Güneysu Yarar, Merve Özmen, Şule Çetin, Tuncer Özekinci","doi":"10.4274/MMJ.galenos.2026.32480","DOIUrl":"10.4274/MMJ.galenos.2026.32480","url":null,"abstract":"<p><strong>Objective: </strong><i>Candida auris</i> (<i>C. auris</i>) has emerged as a multidrug-resistant nosocomial pathogen associated with outbreaks in healthcare settings and high mortality rates. Its ability to persist in the hospital environment highlights the importance of effective disinfection strategies. This study aimed to evaluate the <i>in vitro</i> susceptibility of clinical <i>C. auris</i> isolates to commonly used antiseptics and disinfectants under conditions reflecting routine clinical practice.</p><p><strong>Methods: </strong>Ten clinical <i>C. auris</i> isolates, along with reference strains of <i>C. krusei</i> (ATCC 6258) and <i>C. parapsilosis</i> (ATCC 22019), were tested. Sodium hypochlorite (5%, 1%, 0.5%), hydrogen peroxide (6%, 3%), povidone-iodine (10%, 5%, 2.5%), a chlorhexidine/n-propanol-containing liquid soap, and an ethanol/isopropyl alcohol-based hand disinfectant were evaluated by a qualitative suspension test at contact times of 1, 2, 5, 10, and 30 minutes. Growth inhibition was assessed after incubation.</p><p><strong>Results: </strong>Povidone-iodine at all concentrations, chlorhexidine/n-propanol-containing liquid soap, alcohol-based hand disinfectant, and sodium hypochlorite at 5% and 1% achieved complete growth inhibition of all isolates within the first minute. In contrast, 0.5% sodium hypochlorite and hydrogen peroxide showed reduced efficacy at early contact times. Growth was observed in some <i>C. auris</i> isolates after 1 minute of exposure to 6% hydrogen peroxide, and in a larger proportion of isolates after 1-2 minutes of exposure to 3% hydrogen peroxide. Similar variability was observed in reference strains, particularly with hydrogen peroxide.</p><p><strong>Conclusions: </strong>Commonly used antiseptics and disinfectants are effective against <i>C. auris</i> when applied at appropriate concentrations and contact times. However, reduced efficacy at lower concentrations and with shorter exposure times underscores the importance of proper disinfectant use in preventing environmental persistence and transmission in healthcare settings.</p>","PeriodicalId":37427,"journal":{"name":"Medeniyet medical journal","volume":"41 3","pages":"245-250"},"PeriodicalIF":1.5,"publicationDate":"2026-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13586913/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148991770","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dose-Response Overstatement and Vesicle-Attribution Uncertainty in Hypoxia-Conditioned MSC Exosome Therapy for Androgenetic Alopecia.","authors":"Yujie Cai","doi":"10.4274/MMJ.galenos.2026.39960","DOIUrl":"10.4274/MMJ.galenos.2026.39960","url":null,"abstract":"","PeriodicalId":37427,"journal":{"name":"Medeniyet medical journal","volume":"41 3","pages":"367-369"},"PeriodicalIF":1.5,"publicationDate":"2026-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13586893/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148991809","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of Septoplasty on Cognitive Function.","authors":"Shola Huseynzada, Aslı Çakır Çetin, Hande Evin Eskicioğlu, Ozge Akgul, Mustafa Cenk Ecevit","doi":"10.4274/MMJ.galenos.2026.58291","DOIUrl":"10.4274/MMJ.galenos.2026.58291","url":null,"abstract":"<p><strong>Objective: </strong>This study explored the impact of septoplasty on cognitive functions, including selective attention, information processing speed, and response inhibition and investigated the factors associated with these effects.</p><p><strong>Methods: </strong>A total of 73 patients who underwent septoplasty for septal deviation were included. Assessments were conducted at baseline and again at six months postoperatively to evaluate the nasal obstruction symptom evaluation (NOSE) score, peak nasal inspiratory flow (PNIF), Sniffin' Sticks (SS), retronasal olfactory threshold test (ROTT), and Stroop test. Wilcoxon signed-rank and McNemar's tests were used to analyse differences between repeated measurements obtained before and after surgery. Additionally, Spearman's correlation, linear regression, and logistic regression analyses were performed. Results with p-value ≤0.05 were considered significant.</p><p><strong>Results: </strong>Postoperative assessments revealed statistically significant improvements in NOSE, PNIF, SS discrimination, SS TDI, ROTT, and Stroop A-D scores (each p<0.05). SS TDI and ROTT scores were significantly correlated both preoperatively (r=0.238) and postoperatively (r=0.295). Furthermore, significant correlations were observed among NOSE, PNIF, SS, ROTT, and Stroop tests. However, PNIF, SS, and ROTT did not show any statistically significant improvement in the postoperative cognitive test results.</p><p><strong>Conclusions: </strong>Septoplasty significantly improved nasal airflow, both orthonasal and retronasal olfaction, and cognitive functions, including selective attention, information-processing speed, and response inhibition. However, it is unclear whether cognitive improvements are attributable to enhanced olfactory function or alleviation of nasal obstruction.</p>","PeriodicalId":37427,"journal":{"name":"Medeniyet medical journal","volume":" ","pages":"251-260"},"PeriodicalIF":1.5,"publicationDate":"2026-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13586908/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148438372","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Methodological Reporting Quality of Artificial Intelligence-Based Orthopedic Studies: A Literature Analysis.","authors":"Gündüz Ercan Kutluay, Ahmet Furkan Kumru","doi":"10.4274/MMJ.galenos.2026.42387","DOIUrl":"10.4274/MMJ.galenos.2026.42387","url":null,"abstract":"<p><strong>Objective: </strong>We set out to examine how completely artificial intelligence (AI)-based orthopedic studies report their methods.</p><p><strong>Methods: </strong>A PubMed search covering 2023-2025 was run with a predefined strategy. Screening of titles, abstracts and full texts left 280 eligible papers, and 200 of these were drawn at random for scoring. Each paper was rated against a six-item framework built from the TRIPOD-AI, STARD-AI and CONSORT-AI guidelines.</p><p><strong>Results: </strong>Mean score across the 200 studies was 4.8±0.9. Twenty-eight percent reached 6/6, 37% scored 5/6 and 23% scored 4/6; the remaining 12% scored 3 or below. Model description, dataset characteristics and performance metrics appeared in every paper (100%), and training and validation procedures in 88%. External validation was far less common, reported by only 32%, while 61% included some form of clinical comparison.</p><p><strong>Conclusions: </strong>Reporting in this literature is moderate to high overall, yet two weaknesses persist: external validation and clinical integration. Work in this area would benefit from closer attention to generalizability, clinical relevance and the existing reporting guidelines.</p>","PeriodicalId":37427,"journal":{"name":"Medeniyet medical journal","volume":" ","pages":"261-265"},"PeriodicalIF":1.5,"publicationDate":"2026-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13586904/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148874917","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of Early Diagnostic Methods for Subclinical Cardiovascular Changes in Childhood Obesity.","authors":"Meryem Badem, Merve Nur Hepokur, Selen Karagozlu, Hamdi Cihan Emeksiz","doi":"10.4274/MMJ.galenos.2026.59783","DOIUrl":"10.4274/MMJ.galenos.2026.59783","url":null,"abstract":"<p><p>Childhood obesity is associated with early cardiometabolic abnormalities and subclinical vascular and cardiac changes. This narrative review summarizes the mechanisms underlying these changes and evaluates non-invasive methods used for early detection. PubMed/MEDLINE and Scopus were searched for pediatric studies, systematic reviews, and guidelines, and the principal evidence sources were appraised using design-appropriate tools. Blood pressure measurement, anthropometry, and age-and risk-based laboratory testing remain the basis of routine assessment. Carotid intima-media thickness, pulse wave velocity, endothelial function tests, heart rate variability, advanced echocardiographic measures, and epicardial adipose tissue assessment are promising; however, methodological heterogeneity and limited pediatric reference values restrict most of them to selected clinical or research settings. Standardized longitudinal studies are required to validate thresholds and determine whether test-guided strategies improve outcomes.</p>","PeriodicalId":37427,"journal":{"name":"Medeniyet medical journal","volume":" ","pages":"296-308"},"PeriodicalIF":1.5,"publicationDate":"2026-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13586907/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148866913","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neutrophil-to-HDL-C Ratio and Anatomically Significant Multivessel Disease Across Acute Coronary Syndrome Phenotypes.","authors":"Yusuf Yilmaz, Sera Celik, Adem Atici, Fatma Betül Ozcan, Arda Demir, Muzaffer Kahyaoglu, Mehmet Celik, Kıvanç Güneş Altun, Ömer Faruk Baycan, Şeref Kul, Mustafa Caliskan","doi":"10.4274/MMJ.galenos.2026.62282","DOIUrl":"10.4274/MMJ.galenos.2026.62282","url":null,"abstract":"<p><strong>Objective: </strong>The neutrophil-to-high-density lipoprotein cholesterol ratio (NHR) is an emerging inflammatory-lipid biomarker. Whether NHR is associated with anatomically significant multivessel disease (MVD) across different acute coronary syndrome (ACS) phenotypes remains unclear.</p><p><strong>Methods: </strong>We analyzed 421 consecutive ACS patients [268 with non-ST-segment elevation myocardial infarction (NSTEMI) and 153 with ST-segment elevation myocardial infarction (STEMI)] who underwent coronary angiography. Anatomically significant MVD was defined as ≥70% stenosis in at least two major epicardial coronary arteries, or ≥70% stenosis in one epicardial coronary artery in addition to ≥50% stenosis of the left main coronary artery. Receiver operating characteristic analysis and multivariable logistic regression were performed.</p><p><strong>Results: </strong>Among NSTEMI patients, NHR predicted anatomically significant MVD with an area under the curve (AUC) of 0.694 [95% confidence interval (CI): 0.630-0.757, p<0.001], using an optimal cut-off value of 0.1365 (78.0% sensitivity, 59.4% specificity). After multivariable adjustment, NHR remained independently associated with MVD (odds ratio: 5.870, 95% CI: 1.402-11.859, p<0.001). Among STEMI patients, NHR did not demonstrate discriminatory ability (AUC=0.481, p=0.690). In the overall ACS population, the NHR demonstrated modest discriminatory performance (AUC=0.615, p<0.001).</p><p><strong>Conclusions: </strong>NHR was associated with anatomically significant MVD mainly in patients with NSTEMI, whereas no meaningful discriminatory value was observed in patients with STEMI. This phenotype-specific finding suggests that NHR may better reflect the presence of MVD in NSTEMI than serve as a uniform marker across all ACS presentations.</p>","PeriodicalId":37427,"journal":{"name":"Medeniyet medical journal","volume":" ","pages":"266-275"},"PeriodicalIF":1.5,"publicationDate":"2026-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13586910/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148875044","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Vestibular Migraine: A Systematic Literature Search and Narrative Review of Diagnostic Criteria, Pathophysiology, Differential Diagnosis, and Treatment Approaches.","authors":"Ülkü Figen Demir, Fatmanur Karakus Dilbaz","doi":"10.4274/MMJ.galenos.2026.94020","DOIUrl":"10.4274/MMJ.galenos.2026.94020","url":null,"abstract":"<p><p>This review aimed to summarize current evidence on the diagnostic criteria, pathophysiological mechanisms, differential diagnosis, and treatment approaches of vestibular migraine. A systematic literature search was conducted in PubMed/MEDLINE, Web of Science, and the Cochrane Library for studies published between May 2021 and May 2026. The search focused on vestibular migraine, migrainous vertigo, migraine-associated vertigo, diagnostic criteria, pathophysiology, treatment, prophylaxis, rehabilitation, and calcitonin gene-related peptide (CGRP)-related therapies. Study selection followed a PRISMA-informed process, and findings were synthesized narratively because of heterogeneity in study design, populations, interventions, and outcome measures. A total of 663 records were identified, and 72 studies were included in the final synthesis. Current evidence supports vestibular migraine as a complex disorder involving trigeminovascular activation, CGRP signaling, central sensitization, vestibulo-thalamo-cortical networks, and cerebellar compensation. Diagnosis remains primarily clinical and requires careful assessment of attack duration, vestibular symptom type, migraine-associated features, and exclusion of alternative vestibular or vascular disorders. Treatment evidence remains limited and heterogeneous. Lifestyle modification, conventional migraine prophylaxis, vestibular rehabilitation, and CGRP-targeted therapies may be useful in selected patients, but robust vestibular migraine-specific randomized trials are still insufficient. Vestibular migraine should be approached as a multisystem neurovestibular disorder rather than a simple coexistence of migraine and vertigo. Individualized, phenotype-based management and stronger controlled studies are needed to improve diagnostic accuracy and therapeutic decision-making.</p>","PeriodicalId":37427,"journal":{"name":"Medeniyet medical journal","volume":" ","pages":"329-346"},"PeriodicalIF":1.5,"publicationDate":"2026-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13586909/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148819882","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Caspase-8 Polymorphism and Colorectal Cancer Risk: A Meta-Analysis of 35,854 Subjects.","authors":"Jun Wang, Chuncui Ye","doi":"10.4274/MMJ.galenos.2026.43592","DOIUrl":"10.4274/MMJ.galenos.2026.43592","url":null,"abstract":"<p><strong>Objective: </strong>Caspase-8 (CASP8) is essential for apoptotic clearance of transformed cells and is encoded by the <i>CASP8</i> gene. The CASP8 -652 6N del polymorphism (rs3834129) has been studied in relation to colorectal cancer (CRC) risk with conflicting outcomes. This meta-analysis aims to provide a consolidated assessment of the association between rs3834129 and susceptibility to CRC.</p><p><strong>Methods: </strong>Eligible case-control studies published up to January 2025 were systematically retrieved from PubMed, Web of Science, and China National Knowledge Infrastructure. For each study, the association of the CASP8 -652 6N del polymorphism with CRC risk was assessed using odds ratios (ORs) and 95% confidence intervals (CIs).</p><p><strong>Results: </strong>A total of 22 studies derived from 12 eligible articles involving 15,327 patients with CRC and 20,527 control subjects were enrolled in this meta-analysis. Collectively, the CASP8 -652 6N del variant correlated with reduced CRC risk under the heterozygote genetic model (OR=0.94, 95% CI: 0.89-0.99). When stratifying analyses according to ethnic background, comparable protective associations were detected within Asian populations. By contrast, no statistically meaningful link was identified between this polymorphism and CRC susceptibility among Caucasian individuals. Further stratification based on tumor site revealed no significant correlations for either colon cancer or rectal cancer subgroups.</p><p><strong>Conclusions: </strong>This meta-analysis provides evidence that the CASP8 -652 6N del polymorphism may be linked to a moderately decreased risk of CRC in Asian subjects.</p>","PeriodicalId":37427,"journal":{"name":"Medeniyet medical journal","volume":" ","pages":"236-244"},"PeriodicalIF":1.5,"publicationDate":"2026-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13586912/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148841182","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}