Medeniyet medical journal最新文献

{"title":"Three-Year Assault Cases Performed on the Emergency Trauma Center.","authors":"Melih Yucel Sanlier, Behcet Al, Volkan Celebi, Gorkem Alper Solakoglu, Eltaf Torun, Kurtulus Aciksari, Bilgehan Ahmet Cumhur, Nafiye Sanlier","doi":"10.4274/MMJ.galenos.2024.61426","DOIUrl":"10.4274/MMJ.galenos.2024.61426","url":null,"abstract":"<p><strong>Objective: </strong>This study aims to compare the results of cases with a history of assault presented to our emergency department over a period of three years with literature data and to share our experiences with colleagues.</p><p><strong>Methods: </strong>Demographic characteristics, trauma findings, clinical conditions, surgical interventions, mortality, and outcomes of patients with a history of assault to the emergency department between 2020 and 2022 were retrospectively examined. The results were analyzed using the Number Cruncher Statistical System 2007 Statistical Software package program (Utah, USA).</p><p><strong>Results: </strong>A total of 2900 patients, including 1850 males (63.79%) and 1050 females (36.21%), with an average age of 35.53±12.46 years, were included in the study. Most admissions (31.28%) occurred during the summer months and outside working hours. Males inflicted all injuries. The most common injuries occurred in the head-neck region (63.31%) and upper extremities (47.97%) in both sexes. Facial injuries were significantly more common in males (p=<0.05), whereas spinal and pelvic injuries were common in females (p<0.05). Tenderness, edema, hematoma, abrasion, ecchymosis, and soft tissue laceration were the most frequently observed findings. Female patients were more likely to be discharged home (p=0.0001), whereas male patients had a higher hospitalization rate (p=0.0001). Life-threatening ailments were discovered in 23 patients (0.79%). Surgical intervention was performed in 50 patients (1.72%). No patient experienced fatal outcomes.</p><p><strong>Conclusions: </strong>All assaults were committed by males. Males are more frequently and severely assaulted than females. The victims were mainly from young people, and assaults predominantly occurred during the summer months and outside working hours. Head-neck and extremity injuries were the most common. There were no fatal outcomes. Nine of the 10 patients were discharged to home from the emergency department.</p>","PeriodicalId":37427,"journal":{"name":"Medeniyet medical journal","volume":"39 4","pages":"293-301"},"PeriodicalIF":1.1,"publicationDate":"2024-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11683297/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142899041","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Endoscopic Type 1 Tympanoplasty: Evaluation of Clinical Success and Hearing Improvement.","authors":"Aynur Aliyeva, Ramil Hashimli","doi":"10.4274/MMJ.galenos.2024.88278","DOIUrl":"10.4274/MMJ.galenos.2024.88278","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to assess the functional and clinical outcomes of endoscopic Type 1 tympanoplasty in patients with chronic otitis media and tympanic membrane perforations, focusing on hearing improvement and graft success rates.</p><p><strong>Methods: </strong>This retrospective study included 46 patients with dry tympanic membrane perforations who underwent endoscopic Type 1 tympanoplasty. Audiometric data, including pure tone averages (PTA) and air-bone gap (ABG) measurements at four frequencies (500, 1000, 2000, and 4000 Hz), were collected preoperatively and postoperatively. Functional success was defined as a postoperative ABG of 20 dB, whereas the integrity of the graft determined clinical success.</p><p><strong>Results: </strong>The mean preoperative ABG was 36.74±7.62 dB, which significantly improved to 15.05±3.82 dB postoperatively (p<0.001). The PTA exhibited an average gain of 28.17±6.87 dB for all frequencies. Functional success was achieved in 42 patients (91.30%), with 17 patients (36.96%) achieving normal hearing and 22 patients (47.83%) presenting with slight hearing loss postoperatively. Anatomical success was achieved in 42 patients (91.30%).</p><p><strong>Conclusions: </strong>Endoscopic Type 1 tympanoplasty is a safe and effective surgical method for treating chronic otitis media, with high rates of both functional and clinical success, significant improvements in hearing outcomes, and minimal postoperative complications.</p>","PeriodicalId":37427,"journal":{"name":"Medeniyet medical journal","volume":"39 4","pages":"268-274"},"PeriodicalIF":1.1,"publicationDate":"2024-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11683289/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142899024","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Histopathological and Immunohistochemical Evaluation of Methotrexate-Induced Gonadal Damage in Rats: Role of SCF, mTOR, and SIRT-1.","authors":"Kübra Tuğçe Kalkan, Betül Yalçın, Özge Cengiz Mat, Arzu Hanım Yay","doi":"10.4274/MMJ.galenos.2024.04932","DOIUrl":"10.4274/MMJ.galenos.2024.04932","url":null,"abstract":"<p><strong>Objective: </strong>Methotrexate (MTX) is a highly effective chemotherapy for cancer. This drug has a gonadotoxic effect, mainly in the testes and ovaries. Our study used histopathological and immunohistochemical methods to assess the potential damage to testicular and ovarian tissue caused by MTX use.</p><p><strong>Methods: </strong>Twenty-four Wistar albino rats, both male and female, were used in our study. Four sets of rats; control male, MTX male, control female, and MTX female were created. The male and female MTX-treated groups received a single intraperitoneal dose of 20 mg/kg MTX. The testes and ovaries of rats sacrificed under general anesthesia were extracted and histopathologically analyzed. In addition, the immunoreactivity intensities of stem cell factor (SCF), mechanistic target of rapamycin (mTOR), and SIRT-1 in both tissues were measured by immunohistochemistry.</p><p><strong>Results: </strong>Johnsen's testicular biopsy score in the testicular seminiferous tubules was significantly lower in the MTX group than in the control group (p<0.001). The ovary showed substantial follicular degeneration (p<0.05), vascular congestion (p<0.01), and fibrosis (p<0.001). MTX reduced SCF immunoreactivity density in the testis and ovary (p<0.05). Furthermore, MTX reduced mTOR, a marker of autophagy, in the testis (p<0.05) and ovary (p<0.001) compared with the control. SIRT-1 intensity increased dramatically in the testis (p<0.001) and ovary (p<0.01) in the injured group, unlike the mTOR marker.</p><p><strong>Conclusions: </strong>Our investigation revealed that the gonads incurred significant damage as a result of MTX. One vital option for reducing or eliminating this damage to the ovaries and testicles is the use of anti-oxidant-rich substances.</p>","PeriodicalId":37427,"journal":{"name":"Medeniyet medical journal","volume":"39 4","pages":"283-292"},"PeriodicalIF":1.1,"publicationDate":"2024-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11683295/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142899031","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Determination of HLA Tissue Type According to the Etiology of Patients with Chronic Renal Failure.","authors":"Burcu Karakus Turan, Fahri Ucar, Vural Taner Yilmaz, Yahya Kilinc, Sule Darbaş Aras, Huseyin Kocak, Nurten Sayin Ekinci, Bulent Aydinli, Habibe Sema Arslan","doi":"10.4274/MMJ.galenos.2024.89801","DOIUrl":"10.4274/MMJ.galenos.2024.89801","url":null,"abstract":"<p><strong>Objective: </strong>Chronic kidney disease (CKD) is a prominent public health concern, is defined as functional and structural damage to the kidneys. This study aims to investigate the association between human leukocyte antigen (HLA) alleles individuals with CKD and the different etiological subgroups of diesease.</p><p><strong>Methods: </strong>Genomic DNA was obtained from peripheral blood samples of 1,079 patients with retrospective CKD and 1,111 healthy control individuals. HLA genotyping was conducted using the Luminex based low-resolution method. Allele frequency distributions were calculated with the help of Arlequin v3.11 population genetics statistics program and SPSS v23.0 program, and p<0.05 values were accepted as significant by chi-square tests.</p><p><strong>Results: </strong>HLA A*02 (21.83%), B*35 (18.30%), DRB1*11 (21.41%) alleles were observed most frequently in individuals with CKD, respectively. In our study, B*08, B*49, B*50 alleles in the HLA B locus (p=0.002, p=0.012 p=0.009) and DRB1*03, *04 alleles in the HLA DRB1 locus (p<0.001, p<0.001) were found positively associated with CKD. A*02, A*11, A*74 alleles at the HLA A locus (p=0.003, p<0.001, p=0.009) and B*27, B*39, B* alleles at the HLA B locus 40, B*59 (p<0.001, p<0.001, p<0.001, p=0.009), DRB1*07, *08, *09, *13, *16 (p<0.001, p=0.012, p=0.007, p<0.001, p<0.001) alleles were determined as negatively associated with the disease. Among the etiological groups of CKD, cystic kidney disease (36.8%), hypertension (16.8%) and urological anomalies (16.6%) were negatively associated with the HLA-DR*13 allele.</p><p><strong>Conclusions: </strong>Since CKD shows serious morbidity and mortality, this comprehensive study of HLA subgroups gave an explanatory idea about which alleles associated with the disease in terms of susceptibility and protection.</p>","PeriodicalId":37427,"journal":{"name":"Medeniyet medical journal","volume":"39 4","pages":"243-253"},"PeriodicalIF":1.1,"publicationDate":"2024-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11683293/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142899020","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Perivascular Invasion: A Promising Prognostic Parameter for Breast Cancer.","authors":"Begüm Çalım Gürbüz, Tuçe Söylemez Akkurt, Handan Eren, Hazal İzol Özmen, Ebru Şen, Burçin Pehlivanoğlu","doi":"10.4274/MMJ.galenos.2024.66169","DOIUrl":"10.4274/MMJ.galenos.2024.66169","url":null,"abstract":"<p><strong>Objective: </strong>Angiotropism/perivascular invasion (PVI) is an emerging topic in various types of cancer, with studies primarily focusing on melanoma. However, limited data are available on the significance of PVI in breast cancer. This study aimed to assess the prognostic significance of PVI in breast cancer and its correlation with traditional clinicopathological prognostic parameters.</p><p><strong>Methods: </strong>A total of 150 patients with breast cancer diagnosed between July 2020 and January 2022 were included. Clinicopathological data were retrieved from the hospital records. The presence of PVI was evaluated on hematoxylin&eosin stained slides, and the association between PVI and clinicopathological parameters was statistically analyzed. A p-value of <0.05 was regarded as statistically significant.</p><p><strong>Results: </strong>All patients were female. The mean age was 54.0±13.6 years (range 26-97 years). PVI was significantly more common in patients with ≥2.5 cm tumors and the absence of PVI showed a significant correlation with a lower histologic grade (p=0.004 and p=0.040, respectively). Lymphovascular invasion (LVI) and perineural invasion (PNI) were also significantly more frequent in tumors with PVI (p=0.001 and 0.02, respectively). There was a statistically significant association between the absence of both PVI and extranodal extension (ENE) (p=0.035).</p><p><strong>Conclusions: </strong>The specific role of PVI in different types of cancer has not yet been clarified. Our findings showed that PVI was significantly associated with tumor size, histological grade, LVI, PNI, and ENE, all of which are well-known negative prognostic factors in breast cancer. The presence of PVI is a promising topic in breast cancer research, and the PVI status in pathology reports may help oncologists perform better risk assessments for patients with breast carcinoma.</p>","PeriodicalId":37427,"journal":{"name":"Medeniyet medical journal","volume":"39 4","pages":"302-308"},"PeriodicalIF":1.1,"publicationDate":"2024-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11683298/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142898976","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Serum Biomarkers in Ulcerative Colitis.","authors":"Semih Sezer, Selim Demirci, Melisa Irem Kara, Murat Korkmaz","doi":"10.4274/MMJ.galenos.2024.94884","DOIUrl":"10.4274/MMJ.galenos.2024.94884","url":null,"abstract":"<p><strong>Objective: </strong>In this study, the aim was to evaluate the diagnostic effectiveness of more easily applicable and cost-effective serum biomarkers, such as neutrophil-to-lymphocyte ratio (NLR), platelet-tolymphocyte ratio (PLR), C-reactive protein (CRP) to albumin ratio (CAR), and CRP-to-lymphocyte ratio (CLR), instead of the endoscopic activity index (EAI) used to determine disease activation in ulcerative colitis (UC) patients.</p><p><strong>Methods: </strong>Blood tests performed during the same period as colonoscopy were reviewed, and NLR, PLR, CAR, and CLR values were calculated. Based on the EAI score, patients with a score <4 were classified as having UC in remission, those with a score ≥4 as having active UC, and those with normal colonoscopy results as the control group.</p><p><strong>Results: </strong>The study included 66 patients with active UC, 31 with UC in remission, and 99 controls. The CLR and CAR values of active and remission UC patients were found to be higher compared with the control group (p<0.001), while no significant difference was found between the groups in terms of PLR and NLR values (p>0.05). The AUC calculated for CLR in diagnosing active UC was significant (p<0.001), and the best cut-off value was determined as >1,75. For CAR, the best cut-off value was calculated as >0.11.</p><p><strong>Conclusions: </strong>This study demonstrated that the CLR and CAR had high sensitivity and specificity for detecting UC activity, whereas the PLR and NLR had low diagnostic value.</p>","PeriodicalId":37427,"journal":{"name":"Medeniyet medical journal","volume":"39 4","pages":"261-267"},"PeriodicalIF":1.1,"publicationDate":"2024-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11683300/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142899039","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Letter to the Editor Regarding on the Manuscript \"Characteristics of Posterior Ethmoidal Artery and its Relationship with Anterior Ethmoidal Artery and Skull Base on CT Scan\".","authors":"Mahmood Dhahir Al-Mendalawi","doi":"10.4274/MMJ.galenos.2024.74505","DOIUrl":"10.4274/MMJ.galenos.2024.74505","url":null,"abstract":"","PeriodicalId":37427,"journal":{"name":"Medeniyet medical journal","volume":"39 4","pages":"330"},"PeriodicalIF":1.1,"publicationDate":"2024-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11683292/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142898957","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical Implications of Pan-Immune-inflammatory Values in Patients with Hypertrophic Cardiomyopathy.","authors":"Levent Pay, Ahmet Cagdas Yumurtas, Seyda Dereli, Tugba Cetin, Hikmet Kadi, Tufan Cinar, Mert Ilker Hayiroglu","doi":"10.4274/MMJ.galenos.2024.96266","DOIUrl":"10.4274/MMJ.galenos.2024.96266","url":null,"abstract":"<p><strong>Objective: </strong>Despite significant advances in understanding hypertrophic cardiomyopathy (HCM) in recent years, there is a need to improve risk stratification for patients at high risk of adverse outcomes. The relationship between inflammation and disease severity in HCM patients is known. Recently, a new inflammation parameter called the pan-immune inflammation value (PIV) has been introduced. However, the relationship between PIV and HCM has not yet been examined. Hence, we aim to investigate the effect of PIV on prognosis in a large series of HCM patients.</p><p><strong>Methods: </strong>The study included 389 consecutive patients with HCM admitted to a tertiary care hospital between 2004 to 2021. The PIV for patients was calculated as: Neutrophil count x platelet count x monocyte count / lymphocyte count. The cohort was categorized into three groups according to PIV, and the association between these groups and long-term mortality was evaluated.</p><p><strong>Results: </strong>Over an average follow-up period of 55.5±12.7 months, long-term mortality occurred in 47 out of 389 patients. Long-term mortality was recorded in 7 patients in tertile 1, 12 patients in tertile 2, and 28 patients in tertile 3. Multivariate regression analysis revealed that long-term all-cause mortality was 3.5 times higher in tertile 3 compared to tertile 1. The receiver-operating characteristic curve based on the PIV had 62% sensitivity and 65% specificity for long-term mortality.</p><p><strong>Conclusions: </strong>High PIV levels may serve as a predictor of long-term mortality in patients with HCM. PIV could be a useful screening tool for identifying HCM patients at increased risk of adverse outcomes.</p>","PeriodicalId":37427,"journal":{"name":"Medeniyet medical journal","volume":"39 4","pages":"254-260"},"PeriodicalIF":1.1,"publicationDate":"2024-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11683294/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142899019","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Letter to the Editor Regarding Manuscript on \"Clinical Characteristics of Children with Acute Post-Streptococcal Glomerulonephritis and the Re-Evaluation of Patients with Artificial Intelligence\".","authors":"Hinpetch Daungsupawong, Viroj Wiwanitkit","doi":"10.4274/MMJ.galenos.2024.63060","DOIUrl":"10.4274/MMJ.galenos.2024.63060","url":null,"abstract":"","PeriodicalId":37427,"journal":{"name":"Medeniyet medical journal","volume":"39 4","pages":"309-310"},"PeriodicalIF":1.1,"publicationDate":"2024-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11683291/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142899037","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Head and Neck Paragangliomas: 16-year Single-center Experience and Mini Review on Diagnosis, Treatment, and Follow-up.","authors":"Gokce Aydemir, Fazil Necdet Ardic, Cuneyt Orhan Kara, Ferda Bir","doi":"10.4274/MMJ.galenos.2024.91668","DOIUrl":"10.4274/MMJ.galenos.2024.91668","url":null,"abstract":"<p><strong>Objective: </strong>To investigate head and neck paraganglioma cases treated at a tertiary center from 2007 to 2023. The research includes a thorough examination of published studies that have focused on long-term outcomes. The additional goal is to contribute to the existing knowledge on head and neck paraganglioma, with a particular emphasis on refining diagnostic algorithms, treatment selection, and follow-up procedures.</p><p><strong>Methods: </strong>A total of 44 patients were retrospectively analyzed, and 39 were included. Demographic information, symptoms, radiological examination results, types, stages, and postoperative complications were recorded. A review was conducted to select articles that reported single-center experiences with large cohorts, long follow-ups, and different treatment modalities since 2010.</p><p><strong>Results: </strong>The mean age of the patients was 54 years, and the female/male ratio was 3.55:1. Among the 39 cases examined, 18 and 19 were identified as cervical paraganglioma and 19 as temporal bone paraganglioma. All patients initially underwent surgical resection. The mean follow-up duration was 5.42 years. Four residual cases and two recurrences were identified postoperatively, and a Gamma Knife was used as additional treatment. Subsequently, 17 articles were selected and summarized, and then a flowchart was prepared showing the possible options for diagnosis, treatment, and follow-up.</p><p><strong>Conclusions: </strong>Preoperative staging is essential for surgical planning and predicting potential intraoperative complications. Based on our findings and review of the articles, we have prepared a flowchart that includes all possibilities depending on the tumor stage to help in the diagnosis, treatment, and follow-up of head and neck paragangliomas.</p>","PeriodicalId":37427,"journal":{"name":"Medeniyet medical journal","volume":"39 3","pages":"192-203"},"PeriodicalIF":1.1,"publicationDate":"2024-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11572209/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142355842","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}