{"title":"嗜酸性粒细胞水平对慢性阻塞性肺疾病(COPD)患者疾病进展和临床结果的影响:一项回顾性研究","authors":"Burcu Arpinar Yigitbas, Esra Ertan Yazar, Elif Hazal Karadag, Elif Yelda Ozgun Niksarlioglu, Coskun Dogan, Fatma Ceren Gurel","doi":"10.4274/MMJ.galenos.2025.27985","DOIUrl":null,"url":null,"abstract":"<p><strong>Objective: </strong>The role of total eosinophil count (EOS) in chronic obstructive pulmonary disease (COPD) remains debated, with studies suggesting both positive and negative impacts on disease progression. This retrospective study aimed to investigate the relationship between stable-state blood EOS levels and clinical outcomes, including hospitalizations, emergency room (ER) visits, and pneumonia, in COPD patients.</p><p><strong>Methods: </strong>Data from 398 COPD patients were analyzed, focusing on blood EOS counts and percentages acquired during stable periods. Patients were categorized based on EOS thresholds of 150 cells/μL and 2%. The number of hospitalizations, ER visits, and pneumonia diagnoses in the preceding year was retrieved from hospital records and patient reports.</p><p><strong>Results: </strong>Patients with EOS levels below 150 cells/μL or 2% showed a significantly higher number of hospitalizations. Additionally, patients with EOS percentages below 2% had higher COPD Assessment Test and Modified Medical Research Council scores, indicating greater symptom burden and dyspnea. Logistic regression analysis confirmed that a lower EOS percentage was an independent predictor of increased hospitalizations, similar to its association with lower FEV1% and more than two ER visits.</p><p><strong>Conclusions: </strong>This study suggests that low blood EOS counts are associated with increased hospitalizations and worse clinical outcomes in COPD patients. This finding highlights the importance of considering EOS levels as a potential biomarker for disease severity and may lead to personalized treatment strategies. Further prospective studies are needed to validate these findings and elucidate the underlying mechanisms.</p>","PeriodicalId":37427,"journal":{"name":"Medeniyet medical journal","volume":"40 3","pages":"150-156"},"PeriodicalIF":1.1000,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12478628/pdf/","citationCount":"0","resultStr":"{\"title\":\"Impact of Eosinophil Levels on Disease Progression and Clinical Outcomes in Chronic Obstructive Pulmonary Disease (COPD) Patients: A Retrospective Study.\",\"authors\":\"Burcu Arpinar Yigitbas, Esra Ertan Yazar, Elif Hazal Karadag, Elif Yelda Ozgun Niksarlioglu, Coskun Dogan, Fatma Ceren Gurel\",\"doi\":\"10.4274/MMJ.galenos.2025.27985\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Objective: </strong>The role of total eosinophil count (EOS) in chronic obstructive pulmonary disease (COPD) remains debated, with studies suggesting both positive and negative impacts on disease progression. This retrospective study aimed to investigate the relationship between stable-state blood EOS levels and clinical outcomes, including hospitalizations, emergency room (ER) visits, and pneumonia, in COPD patients.</p><p><strong>Methods: </strong>Data from 398 COPD patients were analyzed, focusing on blood EOS counts and percentages acquired during stable periods. Patients were categorized based on EOS thresholds of 150 cells/μL and 2%. The number of hospitalizations, ER visits, and pneumonia diagnoses in the preceding year was retrieved from hospital records and patient reports.</p><p><strong>Results: </strong>Patients with EOS levels below 150 cells/μL or 2% showed a significantly higher number of hospitalizations. Additionally, patients with EOS percentages below 2% had higher COPD Assessment Test and Modified Medical Research Council scores, indicating greater symptom burden and dyspnea. Logistic regression analysis confirmed that a lower EOS percentage was an independent predictor of increased hospitalizations, similar to its association with lower FEV1% and more than two ER visits.</p><p><strong>Conclusions: </strong>This study suggests that low blood EOS counts are associated with increased hospitalizations and worse clinical outcomes in COPD patients. This finding highlights the importance of considering EOS levels as a potential biomarker for disease severity and may lead to personalized treatment strategies. Further prospective studies are needed to validate these findings and elucidate the underlying mechanisms.</p>\",\"PeriodicalId\":37427,\"journal\":{\"name\":\"Medeniyet medical journal\",\"volume\":\"40 3\",\"pages\":\"150-156\"},\"PeriodicalIF\":1.1000,\"publicationDate\":\"2025-09-29\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12478628/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Medeniyet medical journal\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.4274/MMJ.galenos.2025.27985\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"MEDICINE, GENERAL & INTERNAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Medeniyet medical journal","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.4274/MMJ.galenos.2025.27985","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"MEDICINE, GENERAL & INTERNAL","Score":null,"Total":0}
Impact of Eosinophil Levels on Disease Progression and Clinical Outcomes in Chronic Obstructive Pulmonary Disease (COPD) Patients: A Retrospective Study.
Objective: The role of total eosinophil count (EOS) in chronic obstructive pulmonary disease (COPD) remains debated, with studies suggesting both positive and negative impacts on disease progression. This retrospective study aimed to investigate the relationship between stable-state blood EOS levels and clinical outcomes, including hospitalizations, emergency room (ER) visits, and pneumonia, in COPD patients.
Methods: Data from 398 COPD patients were analyzed, focusing on blood EOS counts and percentages acquired during stable periods. Patients were categorized based on EOS thresholds of 150 cells/μL and 2%. The number of hospitalizations, ER visits, and pneumonia diagnoses in the preceding year was retrieved from hospital records and patient reports.
Results: Patients with EOS levels below 150 cells/μL or 2% showed a significantly higher number of hospitalizations. Additionally, patients with EOS percentages below 2% had higher COPD Assessment Test and Modified Medical Research Council scores, indicating greater symptom burden and dyspnea. Logistic regression analysis confirmed that a lower EOS percentage was an independent predictor of increased hospitalizations, similar to its association with lower FEV1% and more than two ER visits.
Conclusions: This study suggests that low blood EOS counts are associated with increased hospitalizations and worse clinical outcomes in COPD patients. This finding highlights the importance of considering EOS levels as a potential biomarker for disease severity and may lead to personalized treatment strategies. Further prospective studies are needed to validate these findings and elucidate the underlying mechanisms.
期刊介绍:
The Medeniyet Medical Journal (Medeniyet Med J) is an open access, peer-reviewed, and scientific journal of Istanbul Medeniyet University Faculty of Medicine on various academic disciplines in medicine, which is published in English four times a year, in March, June, September, and December by a group of academics. Medeniyet Medical Journal is the continuation of Göztepe Medical Journal (ISSN: 1300-526X) which was started publishing in 1985. It changed the name as Medeniyet Medical Journal in 2015. Submission and publication are free of charge. No fees are asked from the authors for evaluation or publication process. All published articles are available online in the journal website (www.medeniyetmedicaljournal.org) without any fee. The journal publishes intradisciplinary or interdisciplinary clinical, experimental, and basic researches as well as original case reports, reviews, invited reviews, or letters to the editor, Being published since 1985, the Medeniyet Med J recognizes that the best science should lead to better lives based on the fact that the medicine should serve to the needs of society, and knowledge should transform society. The journal aims to address current issues at both national and international levels, start debates, and exert an influence on decision-makers all over the world by integrating science in everyday life. Medeniyet Med J is committed to serve the public and influence people’s lives in a positive way by making science widely accessible. Believing that the only goal is improving lives, and research has an impact on people’s lives, we select the best research papers in line with this goal.