HACEK细菌的流行病学见解:伊斯坦布尔一家三级保健中心的7年回顾性分析。

IF 1.1 Q2 MEDICINE, GENERAL & INTERNAL
Tansu Dundar, Zafer Habip, Mucahide Esra Kocoglu, Tuncer Ozekinci
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引用次数: 0

摘要

目的:HACEK细菌(副流感嗜血杆菌、聚集杆菌、人心杆菌、艾肯氏菌和金氏菌)代表了一组与心内膜炎和一系列机会性感染有关的挑剔生物。尽管具有重要的临床意义,但HACEK感染的流行病学数据仍然有限,特别是在泰国。方法:回顾性分析伊斯坦布尔一家三级医院在2017-2023年7年间诊断的30例HACEK感染病例。数据收集自电子病历和实验室数据库。结果:患者年龄从0岁到76岁不等,分离株来源于多种临床标本。在已鉴定的物种中,明显没有人源心杆菌。在20例病例中记录了多微生物生长,主要涉及革兰氏阳性球菌,特别是链球菌。对4个分离株进行了抗菌药敏试验,由于缺乏HACEK病原体的标准化指南,因此在解释方面存在重大挑战。所有病例均未接受病原体特异性治疗;所有患者均采用经验性抗菌方案进行管理。除了一名死于2019冠状病毒病并发症的患者外,所有患者的临床结果都很好。随访期间无复发HACEK感染或感染性心内膜炎病例。结论:这些发现强调了与HACEK感染相关的诊断挑战以及对其患病率的潜在低估。需要前瞻性的多中心研究来阐明这些微生物的流行病学和临床意义。此外,制定标准化的抗菌药物敏感性测试方案和循证治疗策略对于优化患者管理和改善临床结果至关重要。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Epidemiological Insights into HACEK Bacteria: A Seven-year Retrospective Analysis at a Tertiary Care Center in Istanbul.

Objective: HACEK bacteria (Haemophilus parainfluenzae, Aggregatibacter spp., Cardiobacterium hominis, Eikenella corrodens, and Kingella kingae) represent a group of fastidious organisms implicated in endocarditis and a range of opportunistic infections. Despite their clinical importance, epidemiological data on HACEK infections remain limited, particularly in Türkiye.

Methods: This retrospective analysis investigated 30 cases of HACEK infections diagnosed at a tertiary care hospital in Istanbul over a seven-year period (2017-2023). Data were collected from electronic medical records and laboratory databases.

Results: Patients ranged in age from 0 to 76 years, with isolates derived from a variety of clinical specimens. Cardiobacterium hominis was notably absent among the identified species. Polymicrobial growth was documented in 20 cases, predominantly involving Gram-positive cocci, particularly Streptococcus spp. Antimicrobial susceptibility testing was performed for four isolates, revealing significant challenges in interpretation due to the absence of standardized guidelines for HACEK pathogens. None of the cases received pathogen-specific therapy; all were managed with empirical antimicrobial regimens. Clinical outcomes were favorable in all but one patient, who succumbed to complications of coronavirus disease-2019. No cases of recurrent HACEK infection or infective endocarditis were observed during follow-up.

Conclusions: These findings underscore the diagnostic challenges associated with HACEK infections and the potential underestimation of their prevalence. Prospective, multicenter studies are needed to clarify the epidemiological and clinical significance of these organisms. Moreover, the development of standardized antimicrobial susceptibility testing protocols and evidence-based therapeutic strategies is essential to optimize patient management and improve clinical outcomes.

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来源期刊
Medeniyet medical journal
Medeniyet medical journal Medicine-Medicine (all)
CiteScore
1.70
自引率
0.00%
发文量
88
审稿时长
5 weeks
期刊介绍: The Medeniyet Medical Journal (Medeniyet Med J) is an open access, peer-reviewed, and scientific journal of Istanbul Medeniyet University Faculty of Medicine on various academic disciplines in medicine, which is published in English four times a year, in March, June, September, and December by a group of academics. Medeniyet Medical Journal is the continuation of Göztepe Medical Journal (ISSN: 1300-526X) which was started publishing in 1985. It changed the name as Medeniyet Medical Journal in 2015. Submission and publication are free of charge. No fees are asked from the authors for evaluation or publication process. All published articles are available online in the journal website (www.medeniyetmedicaljournal.org) without any fee. The journal publishes intradisciplinary or interdisciplinary clinical, experimental, and basic researches as well as original case reports, reviews, invited reviews, or letters to the editor, Being published since 1985, the Medeniyet Med J recognizes that the best science should lead to better lives based on the fact that the medicine should serve to the needs of society, and knowledge should transform society. The journal aims to address current issues at both national and international levels, start debates, and exert an influence on decision-makers all over the world by integrating science in everyday life. Medeniyet Med J is committed to serve the public and influence people’s lives in a positive way by making science widely accessible. Believing that the only goal is improving lives, and research has an impact on people’s lives, we select the best research papers in line with this goal.
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