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The Relationship Between Ossification in Metacarpophalangeal Sesamoids of the Thumb and the Period of Puberty: A Radiographic Study. 拇指掌指骨籽状骨骨化与青春期的关系:影像学研究。
Medeniyet medical journal Pub Date : 2022-12-28 DOI: 10.4274/MMJ.galenos.2022.66743
Rifat Sahin, Cengiz Kazadal
{"title":"The Relationship Between Ossification in Metacarpophalangeal Sesamoids of the Thumb and the Period of Puberty: A Radiographic Study.","authors":"Rifat Sahin,&nbsp;Cengiz Kazadal","doi":"10.4274/MMJ.galenos.2022.66743","DOIUrl":"https://doi.org/10.4274/MMJ.galenos.2022.66743","url":null,"abstract":"<p><strong>Objective: </strong>The current study aimed to determine the onset of sesamoid bones (Sbs) ossification at the thumb metacarpophalangeal (MCP) joint of the hand and its relationship with puberty.</p><p><strong>Methods: </strong>This retrospective radiographic study included patients aged 5-17 years. The presence of Sbs was investigated separately for each age group. Patients were classified based on their age, gender, and the presence of radial and ulnar sesamoids.</p><p><strong>Results: </strong>A total of 1,020 radiographs from 939 patients were analyzed. Sbs began to ossify in girls at the age of 8 years and in boys at the age of 9 years. The ulnar-radial sesamoids were present in all individuals in the same age group at the age of 13-14 years in girls and 15 years in boys. The age at which 50% of the individuals in the same age group had a sesamoid was 10.4 years in girls and 11.9 years in boys on the radial side, 9.5 years in girls, and 11.5 years in boys on the ulnar side.</p><p><strong>Conclusions: </strong>In all individuals, the time between the onset of sesamoids of the MCP joint and development corresponds to the physiological period of puberty. However, the age at which puberty begins coincides with the time when Sbs begin to ossify in 50% of both sexes in the same age group.</p>","PeriodicalId":37427,"journal":{"name":"Medeniyet medical journal","volume":"37 4","pages":"300-305"},"PeriodicalIF":0.0,"publicationDate":"2022-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/e9/9b/medj-37-300.PMC9808854.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10514771","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Advanced-stage Endometrial Stromal Sarcoma Presenting as Primary Infertility in a Young Nulligravida: A Case Report. 晚期子宫内膜间质肉瘤在年轻无孕女性中表现为原发性不孕症:1例报告。
Medeniyet medical journal Pub Date : 2022-09-21 DOI: 10.4274/MMJ.galenos.2022.16132
Ankita Pattanaik, Jasmina Begum, Sweta Singh, Deepthy Balakrishnan, Suvradeep Mitra
{"title":"Advanced-stage Endometrial Stromal Sarcoma Presenting as Primary Infertility in a Young Nulligravida: A Case Report.","authors":"Ankita Pattanaik,&nbsp;Jasmina Begum,&nbsp;Sweta Singh,&nbsp;Deepthy Balakrishnan,&nbsp;Suvradeep Mitra","doi":"10.4274/MMJ.galenos.2022.16132","DOIUrl":"https://doi.org/10.4274/MMJ.galenos.2022.16132","url":null,"abstract":"<p><p>Endometrial stromal sarcoma (ESS) rarely causes infertility in young women. We report a nulligravida in her 30s who presented with primary infertility of 15 years. Hysteroscopy revealed a submucosal necrotic fibroid polyp. Ultrasonography detected multiple intramural fibroids. Open myomectomy with polypectomy was performed. Histopathology revealed low-grade ESS (LGESS) within the fibroid polyp. Subsequently, the patient underwent completion surgery. Her final diagnosis was estrogen-receptor positive LGESS stage IIIB, and she was suggested anastrozole adjuvant therapy and long-term surveillance. ESS with abnormal perimenopausal bleeding, though the most common presentation, may not always observed. Hence, a high index of suspicion of ESS should always be kept as a differential diagnosis in uterine fibroid polyp, though rare. Considering the scarcity of more extensive studies on ESS, reporting of cases will aid in formulating management protocols.</p>","PeriodicalId":37427,"journal":{"name":"Medeniyet medical journal","volume":" ","pages":"293-297"},"PeriodicalIF":0.0,"publicationDate":"2022-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/86/ee/medj-37-293.PMC9500324.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40373652","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Effect of Maternal Age on the Incidence of Major Malformations and Operations in Children with Down Syndrome. 母亲年龄对唐氏综合征患儿重大畸形及手术发生率的影响。
Medeniyet medical journal Pub Date : 2022-09-21 DOI: 10.4274/MMJ.galenos.2022.09086
Elif Yilmaz Gulec, Alper Gezdirici
{"title":"The Effect of Maternal Age on the Incidence of Major Malformations and Operations in Children with Down Syndrome.","authors":"Elif Yilmaz Gulec,&nbsp;Alper Gezdirici","doi":"10.4274/MMJ.galenos.2022.09086","DOIUrl":"https://doi.org/10.4274/MMJ.galenos.2022.09086","url":null,"abstract":"<p><strong>Objective: </strong>Children with Down syndrome have a high incidence of major malformations and corrective surgery. Some patients do not need any surgery, while some cases are operated for several indications. There are few studies investigating the effect of maternal age on the phenotype of these children, despite the fact that increasing maternal age is a known risk factor for giving birth to Down syndrome. We aimed to investigate the incidence of surgery for major malformations and disorders in children with Down syndrome and its relationship with maternal age at birth.</p><p><strong>Methods: </strong>We revised the records of 218 children with Down syndrome for maternal age at birth and for surgical interventions.</p><p><strong>Results: </strong>There were 84 children who had at least one operation with 38.5% incidence. A total of 49 children had cardiac surgery, 16 had gastrointestinal, 17 had head and neck area, 12 had ophthalmological, 12 had genitourinary, 5 had hernia, and 2 had orthopedic surgeries. The mean maternal age was 32.7 (minimum: 15; maximum: 44), and there was no significant difference between operated and non-operated groups for mean maternal ages (32.41 and 32.93, respectively; p=0.89). For any type of surgery, there was no significant difference between the groups with maternal ages 35 and over and those under 35.</p><p><strong>Conclusions: </strong>Maternal age at birth has no effect on the incidence of malformations and the probability of operation in Down syndrome.</p>","PeriodicalId":37427,"journal":{"name":"Medeniyet medical journal","volume":" ","pages":"226-233"},"PeriodicalIF":0.0,"publicationDate":"2022-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/24/ae/medj-37-226.PMC9500329.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40374828","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Comparison of Cardiac Wall Thicknesses and Coronary Artery Obstructions Between Deaths Resulting From Acute Myocardial Infarction and Deaths From Other Causes. 急性心肌梗死死亡与其他原因死亡的心脏壁厚度和冠状动脉阻塞的比较
Medeniyet medical journal Pub Date : 2022-09-21 DOI: 10.4274/MMJ.galenos.2022.54030
Ismail Altin, Mucahit Oruc, Osman Celbis, Emine Turkmen Samanci
{"title":"Comparison of Cardiac Wall Thicknesses and Coronary Artery Obstructions Between Deaths Resulting From Acute Myocardial Infarction and Deaths From Other Causes.","authors":"Ismail Altin,&nbsp;Mucahit Oruc,&nbsp;Osman Celbis,&nbsp;Emine Turkmen Samanci","doi":"10.4274/MMJ.galenos.2022.54030","DOIUrl":"https://doi.org/10.4274/MMJ.galenos.2022.54030","url":null,"abstract":"<p><strong>Objective: </strong>The risk factors for myocardial infarction (MI) can be separated into three general categories: non-modifiable factors, modifiable risk factors, and lifestyle. This study aimed to investigate whether or not there was any effect of cardiac wall thickness and coronary artery obstructions on acute MI.</p><p><strong>Methods: </strong>In this retrospective study of histopathological examinations of autopsies, two groups were formed. The first contained 28 cases diagnosed with acute MI and the second 28 cases with no heart pathology and the cause of death was reasons other than heart disease. The subjects in the two groups were similar in age, height, weight, and body mass index. The groups were compared in terms of the left and right ventricular wall thicknesses and the degree of obstruction of the right, left, anterior descending, and circumflex coronary arteries.</p><p><strong>Results: </strong>The mean left ventricular wall thickness was 1.461±0.2767 cm in the acute MI group and 1.386±0.2460 cm in the control group, with no statistically significant difference found between the two groups (p=0.289). A statistically significant difference in the degree of obstruction of the coronary arteries was found between the groups.</p><p><strong>Conclusions: </strong>Although the mean cardiac wall thickness was greater in the acute MI cases, no statistically significant difference was found between the two groups.</p>","PeriodicalId":37427,"journal":{"name":"Medeniyet medical journal","volume":" ","pages":"220-225"},"PeriodicalIF":0.0,"publicationDate":"2022-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/20/d8/medj-37-220.PMC9500331.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40373954","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Post-COVID-19 Dermatomyositis: A Delayed Reaction That Evades Early Detection. covid -19后皮肌炎:一种逃避早期发现的延迟反应。
Medeniyet medical journal Pub Date : 2022-09-21 DOI: 10.4274/MMJ.galenos.2022.55890
Nur Ili Syazwani Md Hadis, Siti Suhaila Mohd Yusoff, Rosediani Muhamad, Fatin Hanani Che Juha
{"title":"Post-COVID-19 Dermatomyositis: A Delayed Reaction That Evades Early Detection.","authors":"Nur Ili Syazwani Md Hadis,&nbsp;Siti Suhaila Mohd Yusoff,&nbsp;Rosediani Muhamad,&nbsp;Fatin Hanani Che Juha","doi":"10.4274/MMJ.galenos.2022.55890","DOIUrl":"https://doi.org/10.4274/MMJ.galenos.2022.55890","url":null,"abstract":"<p><p>Dermatomyositis (DM) is a rare autoimmune disease that causes symmetrical and predominantly proximal muscle weakness in the limbs and typical skin lesions. Its prevalence increased during the coronavirus disease-2019 (COVID-19) pandemic. Viral infections may cause autoimmunity and trigger the pathogenesis of myositis. We present the case of a man with a long history of myalgia and muscle weakness, who was initially diagnosed with post-COVID-19 myalgia and subsequently developed progressive muscle weakness. Biochemical and muscle biopsy results confirmed DM. The patient responded favorably to the course of steroid treatment.</p>","PeriodicalId":37427,"journal":{"name":"Medeniyet medical journal","volume":" ","pages":"289-292"},"PeriodicalIF":0.0,"publicationDate":"2022-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/b6/6a/medj-37-289.PMC9500330.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40374269","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Prevalence of Malnutrition According to the Global Leadership Initiative on Malnutrition Criteria in Community-dwelling Older Adults in Turkey. 根据土耳其社区居住老年人营养不良标准全球领导倡议的营养不良患病率。
Medeniyet medical journal Pub Date : 2022-09-21 DOI: 10.4274/MMJ.galenos.2022.14377
Filiz Demirdag, Esma Nur Kolbasi, Ozlem Pehlivan
{"title":"Prevalence of Malnutrition According to the Global Leadership Initiative on Malnutrition Criteria in Community-dwelling Older Adults in Turkey.","authors":"Filiz Demirdag,&nbsp;Esma Nur Kolbasi,&nbsp;Ozlem Pehlivan","doi":"10.4274/MMJ.galenos.2022.14377","DOIUrl":"https://doi.org/10.4274/MMJ.galenos.2022.14377","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to investigate the prevalence of malnutrition according to the Global Leadership Initiative on Malnutrition (GLIM) criteria in community-dwelling older adults in Turkey.</p><p><strong>Methods: </strong>Malnutrition was assessed based on the GLIM criteria, and Mini-Nutritional Assessment-Short Form was used for screening. The severity of malnutrition was determined as severe or moderate based on the phenotypic criteria of GLIM.</p><p><strong>Results: </strong>Five hundred sixty-nine (69% female, mean age 74.42±6.58 years) community-dwelling older adults participated in this study. The educational statuses of the participants were as follows: 17.2%, illiterate; 13.3%, literate; 35.3%, primary school; 7.0%, secondary school; 11.1%, high school; and 16.2%, university graduates. Among the participants, 16.4% were living alone, whereas 43.9% of them were living with their spouses. The rest were living with their extended families. According to the GLIM criteria, 24.5% (n=139) of the participants had malnutrition, and 13.9% of the total population had severe malnutrition. Age was significantly associated with malnutrition [odds ratio 1.064, 95% confidence interval (CI) 1.034-1.096, p<0.0001]. No significant difference was found between genders (p=0.207), education groups (p=0.323), and living status (p=0.434) in terms of malnutrition. However, women had higher malnutrition rates than men (26.0% vs. 21.0%) (risk ratio 0.757, 95% CI 0.494-1.160, p=0.207).</p><p><strong>Conclusions: </strong>The prevalence of malnutrition was 24.5%, whereas the rate of severe malnutrition was 13.9% in community-dwelling older adults. Women had higher rates of malnutrition, and age was associated with malnutrition. We recommend for researchers and clinicians to integrate the GLIM criteria into their practices to create a common language in malnutrition assessment.</p>","PeriodicalId":37427,"journal":{"name":"Medeniyet medical journal","volume":" ","pages":"234-239"},"PeriodicalIF":0.0,"publicationDate":"2022-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/b0/02/medj-37-234.PMC9500325.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40374829","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Caregivers' Preferences of COVID-19 Vaccination for Children: A Cross-sectional Study From Rural South India. 照顾者对儿童COVID-19疫苗接种的偏好:来自印度南部农村的横断面研究
Medeniyet medical journal Pub Date : 2022-09-21 DOI: 10.4274/MMJ.galenos.2022.27096
U C Samudyatha, Bhavyashree Balaji, Meghna Singh, Megha Gowda
{"title":"Caregivers' Preferences of COVID-19 Vaccination for Children: A Cross-sectional Study From Rural South India.","authors":"U C Samudyatha,&nbsp;Bhavyashree Balaji,&nbsp;Meghna Singh,&nbsp;Megha Gowda","doi":"10.4274/MMJ.galenos.2022.27096","DOIUrl":"https://doi.org/10.4274/MMJ.galenos.2022.27096","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to document caregivers' perceptions and preferences regarding coronavirus disease-19 (COVID-19) vaccination among children.</p><p><strong>Methods: </strong>This cross-sectional study analyzed 272 caregivers with 347 children (aged 1-18 years) attending a subdistrict rural hospital in February-March 2022.</p><p><strong>Results: </strong>Vaccine acceptance was high (93.4%). Although fear of side effects was the most common reason not to vaccinate, a higher proportion of caregivers willing to vaccinate children had consulted healthcare personnel to clarify queries related to side effects. Familiar vaccination sites, where children had previously received routine immunization (RI), such as government hospitals, and Anganwadis (community-based childcare centers) where vaccines were available free of cost on all working days, were the most preferred for COVID-19 vaccination, followed by schools. Only 5.5% of the caregivers preferred private hospitals. Vaccination at home was desired for chronically ill and out-of-school children. RI as per age was associated with the willingness to vaccinate. In addition to protection from COVID-19, other benefits identified by willing parents were being able to attend schools, recreation, and travel.</p><p><strong>Conclusions: </strong>Out-of-school children, children left or missed out in RI, and children with chronic illness can be at risk of being left out for COVID-19 vaccination and can be included by expanding vaccination services house-to-house as in adults. Media engagement and communication must be interactive to address issues, such as fear of side effects, and promote additional benefits of vaccination.</p>","PeriodicalId":37427,"journal":{"name":"Medeniyet medical journal","volume":" ","pages":"248-254"},"PeriodicalIF":0.0,"publicationDate":"2022-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/2e/77/medj-37-248.PMC9500327.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40371190","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effects of Fish Oil (SMOFlipid®) and Olive Oil Lipid (ClinOleic®) on Neonatal Morbidities in Preterm Infants. 鱼油(smof脂质®)和橄榄油脂质(ClinOleic®)对早产儿新生儿发病率的影响
Medeniyet medical journal Pub Date : 2022-09-21 DOI: 10.4274/MMJ.galenos.2022.83548
Fatih Kilicbay, Aslı Keskin, Ayla Gunlemez
{"title":"Effects of Fish Oil (SMOFlipid<sup>®</sup>) and Olive Oil Lipid (ClinOleic<sup>®</sup>) on Neonatal Morbidities in Preterm Infants.","authors":"Fatih Kilicbay,&nbsp;Aslı Keskin,&nbsp;Ayla Gunlemez","doi":"10.4274/MMJ.galenos.2022.83548","DOIUrl":"https://doi.org/10.4274/MMJ.galenos.2022.83548","url":null,"abstract":"<p><strong>Objective: </strong>Total parenteral nutrition (TPN) is very important for providing optimal nutrition during the critical developmental period of preterm newborns. Thus, there is a need to optimize TPN solutions to reduce morbidities. This study aimed to examine the effects of olive oil (ClinOleic<sup>®</sup>) and fish oil (SMOFlipid<sup>®</sup>) therapies on the frequencies of neonatal morbidities.</p><p><strong>Methods: </strong>Premature newborns hospitalized in the neonatal intensive care unit and receiving TPN for at least 14 days were included in the study. Newborns who were hospitalized and received olive oil-based lipid (ClinOleic<sup>®</sup>) were included in the olive oil group, and those who received omega-3 containing multi-lipid (SMOFlipid<sup>®</sup>) were included in the SMOFlipid group.</p><p><strong>Results: </strong>This study enrolled a total of 222 very-low-birth-weight premature newborns. The breastfeeding rate in the olive oil group was significantly lower than that in the SMOFlipid group (p<0.05). The rate of necrotizing entercolitis (NEC) in the olive oil group was significantly higher than that in the SMOFlipid group (p<0.05). The rate of bronchopulmonary dysplasia (BPD) in the SMOFlipid group was lower than that in the olive oil group (p<0.05).</p><p><strong>Conclusions: </strong>The rates of BPD and NEC were lower in the fish oil group. In this situation, fish oil therapy may provide protection against the development of BPD and NEC. Prospective studies are needed to determine whether this is caused by lipid therapy or an effect of breast milk.</p>","PeriodicalId":37427,"journal":{"name":"Medeniyet medical journal","volume":" ","pages":"240-247"},"PeriodicalIF":0.0,"publicationDate":"2022-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/cb/26/medj-37-240.PMC9500335.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40372793","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Radiomics Features Based on MRI-ADC Maps of Patients with Breast Cancer: Relationship with Lesion Size, Features Stability, and Model Accuracy. 基于乳腺癌患者MRI-ADC图的放射组学特征:与病变大小、特征稳定性和模型准确性的关系
Medeniyet medical journal Pub Date : 2022-09-21 DOI: 10.4274/MMJ.galenos.2022.70094
Begumhan Baysal, Hakan Baysal, Mehmet Bilgin Eser, Mahmut Bilal Dogan, Orhan Alimoglu
{"title":"Radiomics Features Based on MRI-ADC Maps of Patients with Breast Cancer: Relationship with Lesion Size, Features Stability, and Model Accuracy.","authors":"Begumhan Baysal,&nbsp;Hakan Baysal,&nbsp;Mehmet Bilgin Eser,&nbsp;Mahmut Bilal Dogan,&nbsp;Orhan Alimoglu","doi":"10.4274/MMJ.galenos.2022.70094","DOIUrl":"https://doi.org/10.4274/MMJ.galenos.2022.70094","url":null,"abstract":"<p><strong>Objective: </strong>To predict breast cancer molecular subtypes with neural networks based on magnetic resonance imaging apparent diffusion coefficient (ADC) radiomics and to detect the relation of lesion size with the stability of radiomics features.</p><p><strong>Methods: </strong>This retrospective study included 221 consecutive patients (224 lesions) with breast cancer imaged between January 2015 and January 2020. Three sample size configurations were identified based on tumor size (experiment 1: all cases, experiment 2: >1 cm<sup>3</sup>, and experiment 3: >2 cm<sup>3</sup>). The tumors were segmented by three observers based on diffusion-weighted imaging-registered ADC maps, and the volumetric agreement of these segmentations was evaluated using the Dice coefficient. Stability of radiomics features (n=851) was evaluated with intraclass correlation coefficient (ICC, >0.75) and coefficient of variation (CoV, <0.15). Feature selection was made with variance inflation factor (VIF, <10) and least absolute shrinkage and selection operator regression. Outcomes were identified as molecular subtypes (Luminal A, Luminal B, HER2-enriched, triple-negative). Neural network performance was presented as an area under the curve and accuracies.</p><p><strong>Results: </strong>Of the 851 radiomics features, 611 had ICC >0.75, and 37 remained stable in the first experiment, 49 in the second, and 59 in the third based on CoV and VIF analysis. High accuracy was demonstrated by the Luminal B, HER2-enriched, and triple-negative models in the first experiment (>80%), all models in the second experiment, and HER2-enriched and triple-negative models in the third experiment.</p><p><strong>Conclusions: </strong>A positive stability is indicated by an increased lesion size related to radiomics features. Neural networks may predict moleculer subtypes of breast cancers over 1 cm<sup>3</sup> with high accuracy.</p>","PeriodicalId":37427,"journal":{"name":"Medeniyet medical journal","volume":" ","pages":"277-288"},"PeriodicalIF":0.0,"publicationDate":"2022-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/f9/ed/medj-37-277.PMC9500326.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40374268","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Clinicopathological Features of Cutaneous Findings of SARS-CoV-2 Infection. SARS-CoV-2 感染皮肤症状的临床病理特征
IF 1.1
Medeniyet medical journal Pub Date : 2022-09-21 DOI: 10.4274/MMJ.galenos.2022.05046
Bengu Cobanoglu, Filiz Cebeci, Mustafa Simsek, Seyma Ozkanli
{"title":"Clinicopathological Features of Cutaneous Findings of SARS-CoV-2 Infection.","authors":"Bengu Cobanoglu, Filiz Cebeci, Mustafa Simsek, Seyma Ozkanli","doi":"10.4274/MMJ.galenos.2022.05046","DOIUrl":"10.4274/MMJ.galenos.2022.05046","url":null,"abstract":"<p><strong>Objective: </strong>In December 2019, severe acute respiratory syndrome coronavirus-2, which emerged in Wuhan, China, spread rapidly and created a pandemic. Coronavirus disease-2019 (COVID-19) can affect different organ systems, including the skin. Recently, COVID-19 cases with skin lesions of different clinicopathological features have been published. This study aimed to present the histopathological features of 19 COVID-19 cases with cutaneous findings and discuss them in light of the literature.</p><p><strong>Methods: </strong>Skin biopsy specimens of 19 patients with skin rashes associated with COVID-19 were evaluated histopathologically and clinically.</p><p><strong>Results: </strong>Clinical manifestations of rashes developed in eight female, seven male, and four pediatric patients with COVID-19. Urticaria/urticarial vasculitis (n=7), maculopapular eruption (n=7), panniculitis (n=2), purpuric eruptions (n=2), and livedoid-like lesions were noted. Histopathologically, besides the inflammatory findings, the most striking feature was that the vessels were more or less affected in almost all cases.</p><p><strong>Conclusions: </strong>Cutaneous lesions associated with COVID-19 are increasingly being reported. We believe that every data presented about this disease, which has many unknowns, will shed light on future research. Every case can lead us a new way.</p>","PeriodicalId":37427,"journal":{"name":"Medeniyet medical journal","volume":"37 3","pages":"270-276"},"PeriodicalIF":1.1,"publicationDate":"2022-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/94/5b/medj-37-270.PMC9500323.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9175644","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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