Medeniyet medical journal最新文献

{"title":"Protective Effect of Boric Acid on Oxidative Damage and Cognitive Function in Aging Modeled Rats.","authors":"Emel Serdaroglu Kasikci, Burcu Cevreli, Feride Nihal Sinan, Zeynep Gurdere, Aylin Sonmez, Rumeysa Sonmez","doi":"10.4274/MMJ.galenos.2025.22725","DOIUrl":"10.4274/MMJ.galenos.2025.22725","url":null,"abstract":"<p><strong>Objective: </strong>Aging is a degenerative process. Therefore, the background of our study is to evaluate the effects of boron, one of the important underground resources in Türkiye, on aging and related diseases. This study aimed to assess the antioxidant effect and the cognitive functions of boric acid (BA) in a D-galactose (D-gal)-induced aging model.</p><p><strong>Methods: </strong>Eight male Wistar rats, each 12 weeks old, were split into four groups at random: control, D-gal, BA and D-gal+BA. An experimental aging model was induced by a single subcutaneous injection of D-gal (150 mg/kg/day), and BA (100 mg/kg/day) was administered by oral gavage for 12 weeks. The novel object recognition test (NORT) and Morris water maze (MWM) were used to evaluate the cognitive ability of rats.</p><p><strong>Results: </strong>At the end of the experimental period, glutathione (GSH) and malondialdehyde (MDA) levels were assessed in serum and brain tissue. The treatment of D-gal induced aging rats with BA significantly decreased the MDA level (p<0.05) and increased the GSH level, although the increase was not significant. Moreover, NORT and MWM tests showed that BA significantly improved (p<0.05) cognitive deficits in D-Gal + BA treated rats.</p><p><strong>Conclusions: </strong>BA prevents D-gal-induced memory deficit by decreasing oxidative stress. Hence, BA was a good candidate for addressing age-related neurodegenerative disorders and cognitive function improvements.</p>","PeriodicalId":37427,"journal":{"name":"Medeniyet medical journal","volume":"40 1","pages":"18-25"},"PeriodicalIF":1.1,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11974467/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143731966","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correspondence on Effect of Different Doses of Sugammadex on Recovery and Hemodynamic Parameters in Reversing Neuromuscular Blockade in Patients Undergoing Electroconvulsive Therapy.","authors":"Ahmet Ridvan Dogan","doi":"10.4274/MMJ.galenos.2025.75570","DOIUrl":"10.4274/MMJ.galenos.2025.75570","url":null,"abstract":"","PeriodicalId":37427,"journal":{"name":"Medeniyet medical journal","volume":"40 1","pages":"33-34"},"PeriodicalIF":1.5,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11974474/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143731962","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comment on the \"Perivascular Invasion: A Promising Prognostic Parameter for Breast Cancer\".","authors":"Ahmet Bozer","doi":"10.4274/MMJ.galenos.2025.81486","DOIUrl":"10.4274/MMJ.galenos.2025.81486","url":null,"abstract":"","PeriodicalId":37427,"journal":{"name":"Medeniyet medical journal","volume":"40 1","pages":"31-32"},"PeriodicalIF":1.1,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11974473/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143731959","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ocular Manifestations of Kaposi Sarcoma: Insights from an HIV-Positive Patient and an Immunocompetent HIV-Negative Patient.","authors":"Ebubekir Durmus, Esma Ecem Ersoy, Ulviyya Askerova, Fatma Yilmazer","doi":"10.4274/MMJ.galenos.2025.37209","DOIUrl":"10.4274/MMJ.galenos.2025.37209","url":null,"abstract":"<p><p>Kaposi sarcoma (KS) is a vascular neoplasm caused by human herpes virus-8 and is commonly associated with immunocompromised states such as acquired immunodeficiency syndrome. While ocular involvement is rare and typically occurs in human immunodeficiency virus (HIV)-positive patients, it can exceptionally present in HIV-negative, immunocompetent individuals. This report presents two cases of conjunctival KS: One in an HIV-positive patient and another in an HIV-negative patient. The patients were diagnosed and followed up at Istanbul Medeniyet University Göztepe Prof. Dr. Süleyman Yalçın City Hospital. Written informed consent was obtained from the patients for the preparation of this case report. A 35-year-old HIV-positive male with a history of cutaneous and genital KS presented with a painless, reddish, hemorrhagic mass on the left inferior fornix and a firm mass on the lower eyelid. Surgical excision with adjuvant cryotherapy and amniotic membrane transplantation was performed. One year postoperatively, no recurrence or new lesions were observed. A 76-year-old immunocompetent female presented with a painless, progressively enlarging mass in the left inferior fornix. She underwent surgical excision, adjuvant cryotherapy, and amniotic membrane transplantation. Histopathology confirmed the diagnosis of KS, and at the 1-year follow-up, no recurrence or new lesions were observed. Ocular KS, though rare, can occur in both immunocompromised and immunocompetent individuals. This report highlights the importance of considering KS in the differential diagnosis of subconjunctival hemorrhage, even in patients without underlying immunosuppressive conditions. Both cases were successfully managed with surgical excision, adjuvant cryotherapy, and amniotic membrane transplantation, with no recurrence during follow-up.</p>","PeriodicalId":37427,"journal":{"name":"Medeniyet medical journal","volume":"40 1","pages":"26-30"},"PeriodicalIF":1.1,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11974469/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143731964","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Response to the Letter to the Editor Regarding Our Research Article on \"Effect of Different Doses of Sugammadex on Recovery and Hemodynamic Parameters in Reversing Neuromuscular Blockade in Patients Undergoing Electroconvulsive Therapy\".","authors":"Kadir Arslan, Ayca Sultan Sahin","doi":"10.4274/MMJ.galenos.2025.33667","DOIUrl":"10.4274/MMJ.galenos.2025.33667","url":null,"abstract":"","PeriodicalId":37427,"journal":{"name":"Medeniyet medical journal","volume":"40 1","pages":"35-36"},"PeriodicalIF":1.5,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11974475/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143732057","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Response to the Editor Regarding Our Manuscript on \"Clinical Characteristics of Children with Acute Poststreptococcal Glomerulonephritis and Re-evaluation of Patients with Artificial Intelligence\".","authors":"Emre Leventoğlu, Mustafa Soran","doi":"10.4274/MMJ.galenos.2024.02184","DOIUrl":"10.4274/MMJ.galenos.2024.02184","url":null,"abstract":"","PeriodicalId":37427,"journal":{"name":"Medeniyet medical journal","volume":"39 4","pages":"311-329"},"PeriodicalIF":1.5,"publicationDate":"2024-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11683290/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142898998","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Response to Letter to the Editor on the Manuscript \"Posterior Ethmoidal Artery and its Relationship with Anterior Ethmoidal Artery and Skull Base on CT Scan\".","authors":"Thuy Chung Tran Phan, Kiet Vuong Dang","doi":"10.4274/MMJ.galenos.2024.50951","DOIUrl":"10.4274/MMJ.galenos.2024.50951","url":null,"abstract":"","PeriodicalId":37427,"journal":{"name":"Medeniyet medical journal","volume":"39 4","pages":"331"},"PeriodicalIF":1.5,"publicationDate":"2024-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11683299/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142898982","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Effect of Intradermal Injection with Two Different Injection Techniques on Pain and Functional Status in Patients with Chronic Nonspecific Neck Pain.","authors":"Sadiye Murat","doi":"10.4274/MMJ.galenos.2024.78972","DOIUrl":"10.4274/MMJ.galenos.2024.78972","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to compare the effectiveness of different mesotherapy techniques applied at various dermal depths on pain, functional status, and quality of life in patients with non-specific neck pain.</p><p><strong>Methods: </strong>A total of 43 patients who received mesotherapy for non-specific neck pain were retrospectively analyzed. Patients treated with the point-by-point technique (n=21) and the napaj technique (n=22) were recorded. A mixture of 2 mL lidocaine and tenoxicam was used as the mesotherapy solution. Pain was assessed using the visual analog scale (VAS), functional status was assessed using the neck disability index (NDI), and quality of life was assessed using the Nottingham health profile before (T0), after (T1), and 3 months after (T2).</p><p><strong>Results: </strong>In both groups, which were homogeneous in terms of demographic data, statistically significant changes were observed in T1 and T2 values compared with T0 for all evaluation parameters (p=0.001). While both groups demonstrated improvement in all parameters, the posttreatment VAS and NDI score in the point-by-point group was slightly better than that in the napaj group (p=0.042), (p=0.043) but this difference disappeared in the 3-month evaluation.</p><p><strong>Conclusions: </strong>Mesotherapy using a lidocaine-tenoxicam mixture with both the point-by-point and napaj techniques is an effective and safe treatment method for nonspecific neck pain. Both techniques were found to be effective in improving pain, functional status, and quality of life, but neither technique was found to be superior to the other.</p>","PeriodicalId":37427,"journal":{"name":"Medeniyet medical journal","volume":"39 4","pages":"275-282"},"PeriodicalIF":1.1,"publicationDate":"2024-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11683296/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142899003","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Three-Year Assault Cases Performed on the Emergency Trauma Center.","authors":"Melih Yucel Sanlier, Behcet Al, Volkan Celebi, Gorkem Alper Solakoglu, Eltaf Torun, Kurtulus Aciksari, Bilgehan Ahmet Cumhur, Nafiye Sanlier","doi":"10.4274/MMJ.galenos.2024.61426","DOIUrl":"10.4274/MMJ.galenos.2024.61426","url":null,"abstract":"<p><strong>Objective: </strong>This study aims to compare the results of cases with a history of assault presented to our emergency department over a period of three years with literature data and to share our experiences with colleagues.</p><p><strong>Methods: </strong>Demographic characteristics, trauma findings, clinical conditions, surgical interventions, mortality, and outcomes of patients with a history of assault to the emergency department between 2020 and 2022 were retrospectively examined. The results were analyzed using the Number Cruncher Statistical System 2007 Statistical Software package program (Utah, USA).</p><p><strong>Results: </strong>A total of 2900 patients, including 1850 males (63.79%) and 1050 females (36.21%), with an average age of 35.53±12.46 years, were included in the study. Most admissions (31.28%) occurred during the summer months and outside working hours. Males inflicted all injuries. The most common injuries occurred in the head-neck region (63.31%) and upper extremities (47.97%) in both sexes. Facial injuries were significantly more common in males (p=<0.05), whereas spinal and pelvic injuries were common in females (p<0.05). Tenderness, edema, hematoma, abrasion, ecchymosis, and soft tissue laceration were the most frequently observed findings. Female patients were more likely to be discharged home (p=0.0001), whereas male patients had a higher hospitalization rate (p=0.0001). Life-threatening ailments were discovered in 23 patients (0.79%). Surgical intervention was performed in 50 patients (1.72%). No patient experienced fatal outcomes.</p><p><strong>Conclusions: </strong>All assaults were committed by males. Males are more frequently and severely assaulted than females. The victims were mainly from young people, and assaults predominantly occurred during the summer months and outside working hours. Head-neck and extremity injuries were the most common. There were no fatal outcomes. Nine of the 10 patients were discharged to home from the emergency department.</p>","PeriodicalId":37427,"journal":{"name":"Medeniyet medical journal","volume":"39 4","pages":"293-301"},"PeriodicalIF":1.1,"publicationDate":"2024-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11683297/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142899041","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Endoscopic Type 1 Tympanoplasty: Evaluation of Clinical Success and Hearing Improvement.","authors":"Aynur Aliyeva, Ramil Hashimli","doi":"10.4274/MMJ.galenos.2024.88278","DOIUrl":"10.4274/MMJ.galenos.2024.88278","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to assess the functional and clinical outcomes of endoscopic Type 1 tympanoplasty in patients with chronic otitis media and tympanic membrane perforations, focusing on hearing improvement and graft success rates.</p><p><strong>Methods: </strong>This retrospective study included 46 patients with dry tympanic membrane perforations who underwent endoscopic Type 1 tympanoplasty. Audiometric data, including pure tone averages (PTA) and air-bone gap (ABG) measurements at four frequencies (500, 1000, 2000, and 4000 Hz), were collected preoperatively and postoperatively. Functional success was defined as a postoperative ABG of 20 dB, whereas the integrity of the graft determined clinical success.</p><p><strong>Results: </strong>The mean preoperative ABG was 36.74±7.62 dB, which significantly improved to 15.05±3.82 dB postoperatively (p<0.001). The PTA exhibited an average gain of 28.17±6.87 dB for all frequencies. Functional success was achieved in 42 patients (91.30%), with 17 patients (36.96%) achieving normal hearing and 22 patients (47.83%) presenting with slight hearing loss postoperatively. Anatomical success was achieved in 42 patients (91.30%).</p><p><strong>Conclusions: </strong>Endoscopic Type 1 tympanoplasty is a safe and effective surgical method for treating chronic otitis media, with high rates of both functional and clinical success, significant improvements in hearing outcomes, and minimal postoperative complications.</p>","PeriodicalId":37427,"journal":{"name":"Medeniyet medical journal","volume":"39 4","pages":"268-274"},"PeriodicalIF":1.5,"publicationDate":"2024-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11683289/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142899024","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}