Efficacy of Intravenous Ibuprofen and Paracetamol on Postoperative Pain and Tramadol Consumption After Arthroscopic Shoulder Surgery: A Prospective, Randomized, Double-blind Clinical Trial.

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2023-09-28 DOI:10.4274/MMJ.galenos.2023.99975

Muhittin Calim, Serdar Yesiltas, Mustafa Gunay, Ismail Sumer, Sedat Akdas

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引用次数: 0

Abstract

Objective: Efficient pain management following arthroscopic shoulder surgery plays a crucial role in decreasing pain intensity, tramadol consumption, and related side effects. This study primarily aimed to examine the analgesic impact of intravenous (IV) ibuprofen and paracetamol on postoperative pain intensity. In addition, as secondary objectives, the study assesses tramadol consumption, determine the global satisfaction score (GSS), analyze hemodynamic parameters, and investigate tramadol-related side effects. Methods: In this study, we enrolled sixty-four patients who were scheduled to undergo arthroscopic shoulder surgery and met the inclusion criteria of having American Society of Anesthesiologists scores between 1 and 3 and falling within the age range of 18 to 85 years. All participants were managed using IV patient-controlled analgesia. These patients were then randomly assigned in a double-blind manner to two groups: one receiving paracetamol (n=32), and the other receiving ibuprofen (n=32). Demographic information, visual analog scale (VAS) and GSS data, hemodynamics, tramadol consumption, and tramadol-related side effects were recorded. Results: There were no significant differences between the two groups regarding demographics, hemodynamics, GSS scores, and tramadol side effects (respiratory depression, pruritus, urinary retention, and nausea and vomiting). VAS scores of the two groups were similar at postoperative 1st, 6th, and 12th hours. However, group ibuprofen significantly reduced the VAS scores at the postoperative 24th hour (p=0.039). On the other hand, the two groups showed no significant differences in GSS scores. Compared with total tramadol consumption during the postoperative 24-hour period, ibuprofen significantly reduced tramadol consumption (p=0.003). Conclusions: The findings of this study indicate a significant reduction in both pain intensity and tramadol consumption when IV ibuprofen was administered 24 hours following arthroscopic shoulder surgery, in comparison with the use of IV paracetamol.

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静脉注射布洛芬和对乙酰氨基酚对关节镜下肩部手术后疼痛和曲马多消耗的疗效：一项前瞻性、随机、双盲临床试验。

目的：肩关节镜手术后有效的疼痛管理在降低疼痛强度、曲马多用量和相关副作用方面起着至关重要的作用。本研究主要旨在研究静脉注射布洛芬和扑热息痛对术后疼痛强度的镇痛作用。此外，作为次要目标，本研究评估曲马多的消耗量，确定总体满意度评分（GSS），分析血液动力学参数，并调查曲马多相关的副作用。方法：在这项研究中，我们招募了64名患者，他们计划接受关节镜下肩部手术，并符合美国麻醉师协会评分在1到3之间、年龄在18到85岁之间的纳入标准。所有参与者均使用静脉自控镇痛进行管理。然后以双盲方式将这些患者随机分为两组：一组接受扑热息痛治疗（n=32），另一组接受布洛芬治疗（n=32）。记录人口统计学信息、视觉模拟量表（VAS）和GSS数据、血液动力学、曲马多用量和曲马多相关副作用。结果：两组在人口统计学、血液动力学、GSS评分和曲马多副作用（呼吸抑制、瘙痒、尿潴留、恶心呕吐）方面没有显著差异。两组患者术后第1、6、12小时VAS评分相似。然而，布洛芬组在术后24小时显著降低了VAS评分（p=0.039）。另一方面，两组的GSS评分没有显著差异。与术后24小时内的曲马多总消耗量相比，布洛芬显著减少了曲马多的消耗量（p=0.003）。结论：本研究结果表明，与静脉注射扑热息痛相比，关节镜肩部手术后24小时静脉注射布洛芬可显着降低疼痛强度和曲马多消耗量。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.