{"title":"他汀类药物治疗患者的短期和长期持久性及其决定因素。","authors":"Mehmet Uzunlulu, Cundullah Torun, Erhan Eken, Gizem Ayasgil Ulas, Lütfullah Castur","doi":"10.4274/MMJ.galenos.2025.98036","DOIUrl":null,"url":null,"abstract":"<p><strong>Objective: </strong>Despite the established efficacy of statins in reducing major cardiovascular events and mortality, rates of statin persistence remain low. This study aimed to assess short- and long-term statin persistence rates and identify factors influencing persistence in patients initiating statin therapy.</p><p><strong>Methods: </strong>A retrospective, observational, clinical study was conducted, enrolling a consecutive total of 903 patients aged 18 years and older (692 female, 211 male, mean age: 60.74 ± 11.70 years) who had initiated statin therapy between January 1, 2016, and January 1, 2017. Short-term (2018) and long-term (2023) statin persistence statuses were determined. Groups persisting and non-persisting with statin therapy were compared for demographic characteristics; presence of cardiometabolic diseases such as diabetes mellitus (DM), coronary artery disease (CAD), and hypertension (HT); statin therapy intensities; and indications for statin initiation (primary or secondary prevention) for both time periods.</p><p><strong>Results: </strong>The study included 903 patients with a mean age of 60.7±11.7 years and a female predominance of 76.6%. In 2018, 498 (55.1%) patients continued statin therapy, while 405 (44.9%) discontinued. In 2023, excluding 36 cases with death (18 cases were among those continuing statin treatment, and 18 cases were who did not continue). Four hundred and forty-eight (51.7%) patients persisted with statin therapy, while 419 (48.3%) discontinued. Statin non-persistence was more frequent in patients initiated on statins for primary prevention (p<0.01) and more frequent in those under 45 years old (p=0.028 and p=0.036, respectively), while it was less common in patients with HT, DM, and CAD (all p<0.01).</p><p><strong>Conclusions: </strong>The study reveals the low and declining rates of statin persistence in patients initiating statin therapy, both in the short and long term. Furthermore, persistence rates are lower in younger patients and those initiated on statins for primary prevention compared to those with established cardiovascular risk factors.</p>","PeriodicalId":37427,"journal":{"name":"Medeniyet medical journal","volume":"40 3","pages":"136-142"},"PeriodicalIF":1.1000,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12478638/pdf/","citationCount":"0","resultStr":"{\"title\":\"Short- and Long-Term Statin Persistence and Determinants in Patients Initiating Statin Therapy.\",\"authors\":\"Mehmet Uzunlulu, Cundullah Torun, Erhan Eken, Gizem Ayasgil Ulas, Lütfullah Castur\",\"doi\":\"10.4274/MMJ.galenos.2025.98036\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Objective: </strong>Despite the established efficacy of statins in reducing major cardiovascular events and mortality, rates of statin persistence remain low. This study aimed to assess short- and long-term statin persistence rates and identify factors influencing persistence in patients initiating statin therapy.</p><p><strong>Methods: </strong>A retrospective, observational, clinical study was conducted, enrolling a consecutive total of 903 patients aged 18 years and older (692 female, 211 male, mean age: 60.74 ± 11.70 years) who had initiated statin therapy between January 1, 2016, and January 1, 2017. Short-term (2018) and long-term (2023) statin persistence statuses were determined. Groups persisting and non-persisting with statin therapy were compared for demographic characteristics; presence of cardiometabolic diseases such as diabetes mellitus (DM), coronary artery disease (CAD), and hypertension (HT); statin therapy intensities; and indications for statin initiation (primary or secondary prevention) for both time periods.</p><p><strong>Results: </strong>The study included 903 patients with a mean age of 60.7±11.7 years and a female predominance of 76.6%. In 2018, 498 (55.1%) patients continued statin therapy, while 405 (44.9%) discontinued. In 2023, excluding 36 cases with death (18 cases were among those continuing statin treatment, and 18 cases were who did not continue). Four hundred and forty-eight (51.7%) patients persisted with statin therapy, while 419 (48.3%) discontinued. Statin non-persistence was more frequent in patients initiated on statins for primary prevention (p<0.01) and more frequent in those under 45 years old (p=0.028 and p=0.036, respectively), while it was less common in patients with HT, DM, and CAD (all p<0.01).</p><p><strong>Conclusions: </strong>The study reveals the low and declining rates of statin persistence in patients initiating statin therapy, both in the short and long term. Furthermore, persistence rates are lower in younger patients and those initiated on statins for primary prevention compared to those with established cardiovascular risk factors.</p>\",\"PeriodicalId\":37427,\"journal\":{\"name\":\"Medeniyet medical journal\",\"volume\":\"40 3\",\"pages\":\"136-142\"},\"PeriodicalIF\":1.1000,\"publicationDate\":\"2025-09-29\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12478638/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Medeniyet medical journal\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.4274/MMJ.galenos.2025.98036\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"MEDICINE, GENERAL & INTERNAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Medeniyet medical journal","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.4274/MMJ.galenos.2025.98036","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"MEDICINE, GENERAL & INTERNAL","Score":null,"Total":0}
Short- and Long-Term Statin Persistence and Determinants in Patients Initiating Statin Therapy.
Objective: Despite the established efficacy of statins in reducing major cardiovascular events and mortality, rates of statin persistence remain low. This study aimed to assess short- and long-term statin persistence rates and identify factors influencing persistence in patients initiating statin therapy.
Methods: A retrospective, observational, clinical study was conducted, enrolling a consecutive total of 903 patients aged 18 years and older (692 female, 211 male, mean age: 60.74 ± 11.70 years) who had initiated statin therapy between January 1, 2016, and January 1, 2017. Short-term (2018) and long-term (2023) statin persistence statuses were determined. Groups persisting and non-persisting with statin therapy were compared for demographic characteristics; presence of cardiometabolic diseases such as diabetes mellitus (DM), coronary artery disease (CAD), and hypertension (HT); statin therapy intensities; and indications for statin initiation (primary or secondary prevention) for both time periods.
Results: The study included 903 patients with a mean age of 60.7±11.7 years and a female predominance of 76.6%. In 2018, 498 (55.1%) patients continued statin therapy, while 405 (44.9%) discontinued. In 2023, excluding 36 cases with death (18 cases were among those continuing statin treatment, and 18 cases were who did not continue). Four hundred and forty-eight (51.7%) patients persisted with statin therapy, while 419 (48.3%) discontinued. Statin non-persistence was more frequent in patients initiated on statins for primary prevention (p<0.01) and more frequent in those under 45 years old (p=0.028 and p=0.036, respectively), while it was less common in patients with HT, DM, and CAD (all p<0.01).
Conclusions: The study reveals the low and declining rates of statin persistence in patients initiating statin therapy, both in the short and long term. Furthermore, persistence rates are lower in younger patients and those initiated on statins for primary prevention compared to those with established cardiovascular risk factors.
期刊介绍：
The Medeniyet Medical Journal (Medeniyet Med J) is an open access, peer-reviewed, and scientific journal of Istanbul Medeniyet University Faculty of Medicine on various academic disciplines in medicine, which is published in English four times a year, in March, June, September, and December by a group of academics. Medeniyet Medical Journal is the continuation of Göztepe Medical Journal (ISSN: 1300-526X) which was started publishing in 1985. It changed the name as Medeniyet Medical Journal in 2015. Submission and publication are free of charge. No fees are asked from the authors for evaluation or publication process. All published articles are available online in the journal website (www.medeniyetmedicaljournal.org) without any fee. The journal publishes intradisciplinary or interdisciplinary clinical, experimental, and basic researches as well as original case reports, reviews, invited reviews, or letters to the editor, Being published since 1985, the Medeniyet Med J recognizes that the best science should lead to better lives based on the fact that the medicine should serve to the needs of society, and knowledge should transform society. The journal aims to address current issues at both national and international levels, start debates, and exert an influence on decision-makers all over the world by integrating science in everyday life. Medeniyet Med J is committed to serve the public and influence people’s lives in a positive way by making science widely accessible. Believing that the only goal is improving lives, and research has an impact on people’s lives, we select the best research papers in line with this goal.
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