Medeniyet medical journal最新文献

{"title":"Anti-Nuclear Antibody Staining Patterns in Juvenile Idiopathic Arthritis: Association of AC-1 Pattern and Elevated Titers with Uveitis.","authors":"Lutfiye Koru, Fehim Esen, Kardelen Celikel, Özlem Turkyilmaz, Feray Kaya, Elif Kucuk, Zelal Aydin, Eda Nur Dizman, Hatice Kübra Dursun, Merve Ozen Balci, Fatih Haslak, Kubra Ozturk","doi":"10.4274/MMJ.galenos.2025.05490","DOIUrl":"10.4274/MMJ.galenos.2025.05490","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to investigate antinuclear antibody (ANA) staining patterns and titers in patients with juvenile idiopathic arthritis (JIA)-associated uveitis, idiopathic uveitis, and JIA without uveitis, in order to identify serologic profiles that may contribute to disease pathogenesis and guide clinical decision-making.</p><p><strong>Methods: </strong>We analyzed patients with JIA and/or uveitis at our tertiary center with ANA titers ≥1/100. Patients were grouped as JIA-associated uveitis, JIA without uveitis, and idiopathic uveitis. Diagnoses followed International League of Associations for Rheumatology and standardization of uveitis nomenclature criteria. ANA testing was performed by indirect immunofluorescence on <i>HEp-2</i> cells, and patterns and titers were evaluated per International Consensus on ANA Patterns guidelines. ANA profiles were compared across patient groups and JIA subtypes.</p><p><strong>Results: </strong>Ninety-one patients were included: 21 (23%) with idiopathic uveitis, 12 (13.1%) with JIA-associated uveitis, and 58 (63.7%) with JIA without uveitis. The AC-1 pattern was present in all uveitis patients. The most common ANA patterns in JIA were AC-1 (65.7%), AC-4/5 (21.4%), and AC-2 (10%). ANA profiles differed across JIA subtypes (p<0.001), with AC-1 dominant in oligoarticular JIA (74.5%) and AC-4/5 in enthesitis-related arthritis (50%).</p><p><strong>Conclusions: </strong>Our findings show that ANA pattern differences in JIA subtypes may provide significant clues regarding disease pathogenesis and clinical prediction. In particular, the prominence of the AC-1 pattern in JIA-associated uveitis may suggest a potential biomarker for the early identification of uveitis risk, which should be further explored in larger prospective studies.</p>","PeriodicalId":37427,"journal":{"name":"Medeniyet medical journal","volume":"40 3","pages":"180-186"},"PeriodicalIF":1.1,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12478630/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145187093","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the Link between DNA Hypermethylation and HPV in Salivary Gland Tumors.","authors":"Anzila Meer, Sarina Sulong, Anani Aila Mat Zin, Rohimah Mohamud, Norhafiza Mat Lazim","doi":"10.4274/MMJ.galenos.2025.63838","DOIUrl":"10.4274/MMJ.galenos.2025.63838","url":null,"abstract":"<p><p>Salivary gland tumors (SGTs) pose considerable diagnostic and treatment challenges due to their heterogeneous nature, diverse histogenesis, and unpredictable clinical outcomes. Benign tumors exhibit a known recurrence rate, whereas malignant tumors are associated with a poor prognosis and a low recovery rate. Nonetheless, despite the growing body of research, there is insufficient evidence to establish a link between SGTs, human papilloma virus (HPV) infection, and the hypermethylation of tumor suppressor genes. The aim of this study is to elucidate the relationship between DNA hypermethylation and HPV in SGTs, elucidate the role of DNA hypermethylation in HPV-associated SGTs, thereby offering insights into novel diagnostic, and prognostic markers. As epigenetic alterations significantly contribute to the development of carcinogenesis, addressing these epigenetic alterations may help in early treatment plans and early detection of SGTs.</p>","PeriodicalId":37427,"journal":{"name":"Medeniyet medical journal","volume":"40 3","pages":"187-192"},"PeriodicalIF":1.1,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12478624/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145187120","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Is Transient Tachypnea of the Newborn a Risk Factor for Bronchiolitis in the First Two Years of Life? A Population-Based Birth Cohort Study.","authors":"Sinem Can Oksay, Mustafa Kursat Sahin, Gulay Bilgin, Deniz Mavi Tortop, Zeynep Reyhan Onay, Yetkin Ayhan, Askın Keskin Kaplan, Saniye Girit","doi":"10.4274/MMJ.galenos.2025.35306","DOIUrl":"10.4274/MMJ.galenos.2025.35306","url":null,"abstract":"<p><strong>Objective: </strong>Transient Tachypnea of the Newborn (TTN) is a common cause of respiratory distress in term infants, associated with delayed pulmonary fluid clearance resulting from dysfunction of the epithelial sodium channel. Although generally self-limiting, TTN may increase early childhood wheezing and asthma risk. This study aimed to assess the incidence and characteristics of acute bronchiolitis in TTN infants compared to those in healthy controls within a large birth cohort.</p><p><strong>Methods: </strong>We conducted a population-based cohort study that included all live births in Istanbul from January 2016 to December 2018, utilizing the Turkish Ministry of Health's e-Nabız database. Infants diagnosed with isolated TTN (International Classification of Diseases [ICD]-10 P22.1) formed the study group. A randomly selected control group of healthy infants without respiratory diagnoses was included in the study. Both groups were followed for two years to identify episodes of acute bronchiolitis (ICD-10 J21*), excluding cases within the first month of life. The data collected included bronchiolitis incidence, recurrence, age at the time of the episode, and hospitalizations.</p><p><strong>Results: </strong>Among 1,002,261 live births, 14,389 TTN infants and 14,500 controls were analyzed. Acute bronchiolitis occurred in 42.4% of TTN infants and 35.8% of controls (p<0.001). TTN infants had higher rates of single episodes, while controls experienced more recurrent episodes (p<0.001). Hospitalization was more frequent in the control group (p<0.001), with single hospitalizations predominating in the TTN group and multiple hospitalizations in the control group. The first episodes in TTN infants mainly occurred between 1-6 months, with controls showing more episodes early but fewer later (p<0.001). Recurrence was correlated with an earlier age of the first episode in both groups (p<0.001).</p><p><strong>Conclusions: </strong>TTN infants experience more bronchiolitis episodes early in life, though recurrent episodes are more common among healthy controls. Further studies are warranted to investigate the relationship between TTN and the development of wheezing and asthma.</p>","PeriodicalId":37427,"journal":{"name":"Medeniyet medical journal","volume":"40 3","pages":"157-165"},"PeriodicalIF":1.1,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12478643/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145187070","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical Impact of Cerebrospinal Fluid Multiplex Polymerase Chain Reaction (PCR) Testing in Children with Suspected Central Nervous System Infection.","authors":"Aytac Goktug, Idil Ak Gundogdu, Muhterem Duyu, Esen Besli","doi":"10.4274/MMJ.galenos.2025.43895","DOIUrl":"10.4274/MMJ.galenos.2025.43895","url":null,"abstract":"<p><strong>Objective: </strong>Central nervous system (CNS) infections remain a significant cause of morbidity and mortality in children. This study aimed to evaluate the impact of cerebrospinal fluid (CSF), multiplex polymerase chain reaction (PCR) panel results on clinical decision-making and patient management in children who underwent lumbar puncture (LP) with a preliminary diagnosis of meningitis/meningoencephalitis.</p><p><strong>Methods: </strong>Patients aged 1 month to 18 years who underwent LP for suspected CNS infection in our pediatric emergency or intensive care units between 2018 and 2023, and who had a CSF multiplex PCR meningitis/encephalitis panel performed, were retrospectively evaluated in terms of demographics, clinical presentation, laboratory parameters, and treatments. Patients younger than 1 month or older than 18 years, those who underwent LP for non-infectious indications, and those with ventriculoperitoneal shunts were excluded. Data were analyzed using SPSS version 24.</p><p><strong>Results: </strong>The median age of the 144 patients was 2.7 (6.7) years, and 93 (64.6%) were male. At least one pathogen was detected by multiplex PCR in 35 patients (24.3%). Of these, 22 had viral agents (enterovirus in 9, HSV-1 in 4, HHV-8 in 2, HHV-7 in 2, VZV in 2, CMV in 2, and HHV-6 in 1), 11 had bacterial agents [<i>Streptococcus pneumoniae (S. pneumoniae)</i> in 7, <i>Neisseria meningitidis</i> in 3, and <i>Haemophilus influenzae type b (Hib) in 1</i>], and 2 had multiple agents (<i>S. pneumoniae</i> + <i>Hib</i> + HHV-6 in one case; enterovirus + HHV-6 in one case). No significant clinical differences were observed between viral and bacterial infections. In 51 patients (35.4%), treatment was modified based on PCR results, most often by discontinuing acyclovir (22.1%), antibiotics (7.6%), or both (3.5%).</p><p><strong>Conclusions: </strong>In approximately one-third of cases, unnecessary antiviral or antibiotic treatments were discontinued based on PCR results, demonstrating the utility of molecular diagnostics in guiding clinical management. Especially in patients who had received antibiotics prior to LP, early pathogen detection via PCR may help reduce treatment costs, complications, and length of hospital stay.</p>","PeriodicalId":37427,"journal":{"name":"Medeniyet medical journal","volume":"40 3","pages":"128-135"},"PeriodicalIF":1.1,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12478634/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145187022","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Short- and Long-Term Statin Persistence and Determinants in Patients Initiating Statin Therapy.","authors":"Mehmet Uzunlulu, Cundullah Torun, Erhan Eken, Gizem Ayasgil Ulas, Lütfullah Castur","doi":"10.4274/MMJ.galenos.2025.98036","DOIUrl":"10.4274/MMJ.galenos.2025.98036","url":null,"abstract":"<p><strong>Objective: </strong>Despite the established efficacy of statins in reducing major cardiovascular events and mortality, rates of statin persistence remain low. This study aimed to assess short- and long-term statin persistence rates and identify factors influencing persistence in patients initiating statin therapy.</p><p><strong>Methods: </strong>A retrospective, observational, clinical study was conducted, enrolling a consecutive total of 903 patients aged 18 years and older (692 female, 211 male, mean age: 60.74 ± 11.70 years) who had initiated statin therapy between January 1, 2016, and January 1, 2017. Short-term (2018) and long-term (2023) statin persistence statuses were determined. Groups persisting and non-persisting with statin therapy were compared for demographic characteristics; presence of cardiometabolic diseases such as diabetes mellitus (DM), coronary artery disease (CAD), and hypertension (HT); statin therapy intensities; and indications for statin initiation (primary or secondary prevention) for both time periods.</p><p><strong>Results: </strong>The study included 903 patients with a mean age of 60.7±11.7 years and a female predominance of 76.6%. In 2018, 498 (55.1%) patients continued statin therapy, while 405 (44.9%) discontinued. In 2023, excluding 36 cases with death (18 cases were among those continuing statin treatment, and 18 cases were who did not continue). Four hundred and forty-eight (51.7%) patients persisted with statin therapy, while 419 (48.3%) discontinued. Statin non-persistence was more frequent in patients initiated on statins for primary prevention (p<0.01) and more frequent in those under 45 years old (p=0.028 and p=0.036, respectively), while it was less common in patients with HT, DM, and CAD (all p<0.01).</p><p><strong>Conclusions: </strong>The study reveals the low and declining rates of statin persistence in patients initiating statin therapy, both in the short and long term. Furthermore, persistence rates are lower in younger patients and those initiated on statins for primary prevention compared to those with established cardiovascular risk factors.</p>","PeriodicalId":37427,"journal":{"name":"Medeniyet medical journal","volume":"40 3","pages":"136-142"},"PeriodicalIF":1.1,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12478638/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145186432","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"PARP-1 rs1136410 Polymorphism and Gastrointestinal Cancer Risk: A Meta-Analysis of Cancer-Type and Ethnic-Specific Associations.","authors":"Amirhosein Naseri, Mohammad Hossein Antikchi, Sepideh Soleymani, Mehdi Khosravi-Mashizi, Rezvan Nezameslami, Alireza Nezameslami, Bahareh Mehdikhani, Ahmad Shirinzadeh-Dastgiri, Seyed Masoud Haghighikian, Mohammad Vakili-Ojarood, Amirhossein Rahmani, Hossein Neamatzadeh","doi":"10.4274/MMJ.galenos.2025.72708","DOIUrl":"10.4274/MMJ.galenos.2025.72708","url":null,"abstract":"<p><strong>Objective: </strong>Poly (ADP-ribose) polymerase-1 (<i>PARP-1</i>) is a key enzyme in DNA repair pathways and has been implicated in cancer susceptibility. The rs1136410 polymorphism in the <i>PARP-1</i> gene has shown inconsistent associations with gastrointestinal cancer risk across populations. This meta-analysis aimed to evaluate the association between <i>PARP-1</i> rs1136410 polymorphism and the risk of colorectal cancer (CRC) and gastric cancer (GC), with a focus on ethnic differences.</p><p><strong>Methods: </strong>A systematic literature search was performed in PubMed, Scopus, EMBASE, Web of Science, Cochrane Library, BIOSIS, LILACS, CNKI, CBM, Wan Fang, and other regional databases up to February 1, 2025. Eligible case-control studies assessing the association between PARP- 1 rs1136410 polymorphism and CRC or GC were included. Pooled odds ratios (ORs) and 95% confidence intervals (CIs) were calculated under five genetic models using Comprehensive Meta-Analysis software.</p><p><strong>Results: </strong>Thirteen case-control studies were included, comprising 3.591 patients and 5.433 controls. For GC (8 studies; 1,784 cases and 2,521 controls), significant associations were observed under multiple genetic models: allele comparison (C vs. T: OR=2.01, 95% CI 1.04-3.91, p=0.039), homozygous comparison (CC vs. TT: OR=1.77, 95% CI 1.24-2.52, p=0.002), heterozygous comparison (CT vs. TT: OR=1.36, 95% CI 1.18-1.57, p<0.001), and recessive comparison (CC vs. CT+TT: OR=1.54, 95% CI 1.08-2.20, p=0.017). No significant association was detected for CRC (5 studies; 1.807 cases and 2.912 controls). Ethnic subgroup analysis revealed a protective effect against CRC in Caucasians but increased susceptibility in Asians.</p><p><strong>Conclusion: </strong>The <i>PARP-1</i> rs1136410 polymorphism is associated with elevated GC risk but not CRC, with ethnicity-dependent effects suggesting differential genetic susceptibility. These findings highlight the importance of considering population-specific genetic backgrounds in gastrointestinal cancer risk assessment, prevention, and precision medicine strategies.</p>","PeriodicalId":37427,"journal":{"name":"Medeniyet medical journal","volume":"40 3","pages":"116-127"},"PeriodicalIF":1.1,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12478637/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145187099","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of Eosinophil Levels on Disease Progression and Clinical Outcomes in Chronic Obstructive Pulmonary Disease (COPD) Patients: A Retrospective Study.","authors":"Burcu Arpinar Yigitbas, Esra Ertan Yazar, Elif Hazal Karadag, Elif Yelda Ozgun Niksarlioglu, Coskun Dogan, Fatma Ceren Gurel","doi":"10.4274/MMJ.galenos.2025.27985","DOIUrl":"10.4274/MMJ.galenos.2025.27985","url":null,"abstract":"<p><strong>Objective: </strong>The role of total eosinophil count (EOS) in chronic obstructive pulmonary disease (COPD) remains debated, with studies suggesting both positive and negative impacts on disease progression. This retrospective study aimed to investigate the relationship between stable-state blood EOS levels and clinical outcomes, including hospitalizations, emergency room (ER) visits, and pneumonia, in COPD patients.</p><p><strong>Methods: </strong>Data from 398 COPD patients were analyzed, focusing on blood EOS counts and percentages acquired during stable periods. Patients were categorized based on EOS thresholds of 150 cells/μL and 2%. The number of hospitalizations, ER visits, and pneumonia diagnoses in the preceding year was retrieved from hospital records and patient reports.</p><p><strong>Results: </strong>Patients with EOS levels below 150 cells/μL or 2% showed a significantly higher number of hospitalizations. Additionally, patients with EOS percentages below 2% had higher COPD Assessment Test and Modified Medical Research Council scores, indicating greater symptom burden and dyspnea. Logistic regression analysis confirmed that a lower EOS percentage was an independent predictor of increased hospitalizations, similar to its association with lower FEV1% and more than two ER visits.</p><p><strong>Conclusions: </strong>This study suggests that low blood EOS counts are associated with increased hospitalizations and worse clinical outcomes in COPD patients. This finding highlights the importance of considering EOS levels as a potential biomarker for disease severity and may lead to personalized treatment strategies. Further prospective studies are needed to validate these findings and elucidate the underlying mechanisms.</p>","PeriodicalId":37427,"journal":{"name":"Medeniyet medical journal","volume":"40 3","pages":"150-156"},"PeriodicalIF":1.1,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12478628/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145187026","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Epidemiological Insights into HACEK Bacteria: A Seven-year Retrospective Analysis at a Tertiary Care Center in Istanbul.","authors":"Tansu Dundar, Zafer Habip, Mucahide Esra Kocoglu, Tuncer Ozekinci","doi":"10.4274/MMJ.galenos.2025.69327","DOIUrl":"10.4274/MMJ.galenos.2025.69327","url":null,"abstract":"<p><strong>Objective: </strong>HACEK bacteria (<i>Haemophilus parainfluenzae, Aggregatibacter</i> spp., <i>Cardiobacterium hominis, Eikenella corrodens</i>, and <i>Kingella kingae</i>) represent a group of fastidious organisms implicated in endocarditis and a range of opportunistic infections. Despite their clinical importance, epidemiological data on HACEK infections remain limited, particularly in Türkiye.</p><p><strong>Methods: </strong>This retrospective analysis investigated 30 cases of HACEK infections diagnosed at a tertiary care hospital in Istanbul over a seven-year period (2017-2023). Data were collected from electronic medical records and laboratory databases.</p><p><strong>Results: </strong>Patients ranged in age from 0 to 76 years, with isolates derived from a variety of clinical specimens. <i>Cardiobacterium hominis</i> was notably absent among the identified species. Polymicrobial growth was documented in 20 cases, predominantly involving Gram-positive cocci, particularly <i>Streptococcus</i> spp. Antimicrobial susceptibility testing was performed for four isolates, revealing significant challenges in interpretation due to the absence of standardized guidelines for HACEK pathogens. None of the cases received pathogen-specific therapy; all were managed with empirical antimicrobial regimens. Clinical outcomes were favorable in all but one patient, who succumbed to complications of coronavirus disease-2019. No cases of recurrent HACEK infection or infective endocarditis were observed during follow-up.</p><p><strong>Conclusions: </strong>These findings underscore the diagnostic challenges associated with HACEK infections and the potential underestimation of their prevalence. Prospective, multicenter studies are needed to clarify the epidemiological and clinical significance of these organisms. Moreover, the development of standardized antimicrobial susceptibility testing protocols and evidence-based therapeutic strategies is essential to optimize patient management and improve clinical outcomes.</p>","PeriodicalId":37427,"journal":{"name":"Medeniyet medical journal","volume":"40 3","pages":"143-149"},"PeriodicalIF":1.1,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12478635/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145187100","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Loneliness in Retirement.","authors":"Alen Greš, Nika Spasić, Dijana Staver","doi":"10.4274/MMJ.galenos.2025.24804","DOIUrl":"10.4274/MMJ.galenos.2025.24804","url":null,"abstract":"<p><strong>Objective: </strong>Loneliness has been identified as a subjective unpleasant feeling of emptiness and distress, affecting diverse age groups, particularly retirees. Retirement is a major life event characterized by the cessation of professional activities and the loss of regular income. These phenomena are often combined and their relationship can be complex.</p><p><strong>Methods: </strong>The research encompassed 75 randomly selected outpatients at the University Hospital Center Zagreb, Department for Psychiatry and Psychological Medicine in Zagreb Croatia with an anxiety disorder who were in remission and met the inclusion criteria. The participants were divided into three groups of 25 respondents: five years before retirement, one year before retirement, and one year after retirement. The participants were tested once using psychological tests: The University of California, Los Angeles (UCLA); and the Mini International Neuropsychiatric Interview.</p><p><strong>Results: </strong>This study examined loneliness among 75 participants across retirement phases. UCLA Loneliness Scale scores increased significantly from pre to post-retirement (p<0.001), peaking one year after retirement. Emotional loneliness, particularly feelings of isolation, rose sharply, while social loneliness increased gradually. A One-Way Analysis of Variance confirmed a significant effect of retirement on loneliness, F (2.72)=24,561, p<0.001, with an impact level of η²=0.405. A substantial impact is observed on emotional and social well-being.</p><p><strong>Conclusions: </strong>Study results indicate a significant increase in loneliness among retired individuals. Transition to retirement can have an impact on individuals' emotions and social interactions. There is a need to support retirees in establishing new daily routines.</p>","PeriodicalId":37427,"journal":{"name":"Medeniyet medical journal","volume":"40 2","pages":"53-60"},"PeriodicalIF":1.1,"publicationDate":"2025-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12203447/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144508710","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Role of Combined C-reactive Protein and Albumin Indices in Predicting Prolonged Hospital Stay in Acute Pancreatitis: A Prospective Observational Study.","authors":"Abdullah Algin, Serdar Ozdemir, Mustafa Ahmet Afacan, Kaan Yusufoglu, Abuzer Ozkan","doi":"10.4274/MMJ.galenos.2025.73848","DOIUrl":"10.4274/MMJ.galenos.2025.73848","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate the predictive ability of indices based on the combination of C-reactive protein (CRP) and albumin, namely the CRP/albumin ratio (CAR), Glasgow prognostic score (GPS), and modified GPS (mGPS), for prolonged hospital stay in patients with acute pancreatitis.</p><p><strong>Methods: </strong>This prospective observational study was conducted on patients monitored in the emergency department of a tertiary university hospital. The patients' demographic data, vital signs, laboratory parameters, comorbidities, and length of hospital stay were prospectively recorded. Based on their length of hospital stay, the patients were divided into two groups: prolonged stay (>7 days) and non-prolonged stay. The indices were compared between these groups.</p><p><strong>Results: </strong>There were statistically significant differences in CAR, GPS, and mGPS between the prolonged and non-prolonged hospital stay groups (p<0.001 for all; chi-square test). The area under the curve values of CAR, GPS, and mGPS were calculated as 0.677 [95% confidence interval (CI): 0.601-0.753, p<0.001], 0.637 (95% CI: 0.570-0.704, p<0.001), and 0.671 (95% CI: 0.602-0.740, p<0.001), respectively. According to multivariate analysis, CAR [odds ratio (OR)=1.017, 95% CI (1.003-1.03), p=0.015], GPS [OR=2.894, 95% CI (1.632-5.13), p<0.001], and mGPS [OR=3.757, 95% CI (2.108-6.70), p<0.001] were found to be independent predictors of prolonged hospital stay.</p><p><strong>Conclusions: </strong>CAR, GPS, and mGPS are independent predictors of prolonged hospital stay in patients with acute pancreatitis. The findings also suggest that incorporating CRP levels into prognostic calculations may yield more accurate results compared to scores based solely on albumin levels.</p>","PeriodicalId":37427,"journal":{"name":"Medeniyet medical journal","volume":"40 2","pages":"72-79"},"PeriodicalIF":1.1,"publicationDate":"2025-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12203446/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144508712","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}