Medeniyet medical journal最新文献

{"title":"Knowledge, Attitude, and Stigma on Tuberculosis and the Associated Factors for Attitude Among Tuberculosis Contacts in Malaysia.","authors":"Shin Yee Loh,&nbsp;Rosnani Zakaria,&nbsp;Noraini Mohamad","doi":"10.4274/MMJ.galenos.2023.14478","DOIUrl":"https://doi.org/10.4274/MMJ.galenos.2023.14478","url":null,"abstract":"<p><strong>Objective: </strong>Tuberculosis (TB) is an old disease and it has infected millions of people worldwide. Since it is a highly infectious disease, many people became TB contact due to prolonged exposure to a person with TB infection. This group of people is at a higher risk of getting latent and active TB infection, hence a vulnerable group for active TB screening. This study explored the factors that determined the attitude score, the level of knowledge, attitude, and stigma (KAS) regarding TB disease among TB contact.</p><p><strong>Methods: </strong>This cross-sectional study used a validated KAS questionnaire, performed among 338 TB contacts from 5 health clinics in Kedah, Malaysia. The respondents were selected via convenience sampling. Simple and multiple linear regressions were used to analyze the data.</p><p><strong>Results: </strong>The mean KAS scores of participants are 73.5% [standard deviation (SD)=17.06], 83.0% (SD=10.33), and 67.0% (SD=16.72), respectively. Higher income (p=0.001), better knowledge score (p<0.001), and higher stigma score (p=0.003) are the significant associated factors for the attitude score.</p><p><strong>Conclusions: </strong>This study revealed that most of the TB contacts have good knowledge and constructive attitude toward TB prevention and screening, but their level of stigma on TB is high. The implementation of TB education and intervention programs among TB contacts are required especially among low-income groups.</p>","PeriodicalId":37427,"journal":{"name":"Medeniyet medical journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/ba/6e/medj-38-45.PMC10064099.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9239101","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"How Does Preoperative Pure Tone Audiometry Relate to the Findings at Surgery to Explain the Hearing Status in Chronic Otitis Media?","authors":"Sharafali Kadambott,&nbsp;Prasanta Kumar Gure,&nbsp;Soumya Ghatak,&nbsp;Mainak Dutta,&nbsp;Chandan Seth,&nbsp;Saumik Das,&nbsp;Ramanuj Sinha","doi":"10.4274/MMJ.galenos.2023.30509","DOIUrl":"https://doi.org/10.4274/MMJ.galenos.2023.30509","url":null,"abstract":"<p><strong>Objective: </strong>Pure tone audiometry (PTA) guides surgical decision-making in chronic otitis media (COM), and PTA values depend upon the type and extent of COM.</p><p><strong>Methods: </strong>Our cross-sectional study included patients with COM with/without cholesteatoma who were scheduled for surgery. Findings on examination of the middle ear under the microscope and at surgery which could explain the hearing loss were corroborated with preoperative PTA through appropriate statistical methods.</p><p><strong>Results: </strong>The study included 114 patients (mean age: 31.07 years; range: 7-57). Following preoperative PTA, 50% of patients had moderate hearing loss and ~73% had air-bone gap (ABG) <35 dB. Conductive hearing loss affected 109 patients (97.61%); five had mixed hearing loss. At surgery, 27 patients (23.68%) had ossicular discontinuity, with the incus being the most affected. Twenty-one patients in this group had ABG ≥35 dB. Perforations involving the anterior and posterior halves of the pars tensa, and subtotal perforations, demonstrated the maximum mean hearing loss [45.39±8.29 dB HL (p=0.075), 51.08±12.51 dB HL (p=0.26), respectively]. The mean pure tone average in the intact ossicles group was 43.62±8.07 dB HL and that in the absent/eroded ossicles group was 58.15±11.05 dB HL (p<0.0001); the mean ABG was 27.89±4.77 dB and 38.88±6.47 dB, respectively (p<0.0001).</p><p><strong>Conclusions: </strong>Hearing loss was significantly associated with the size but not the site of the central perforation. With ossicular discontinuity, hearing loss and ABG deteriorated significantly. The findings re-establish the relationship between preoperative PTA and the middle ear status which should help surgeons plan surgery and counsel patients regarding hearing outcomes.</p>","PeriodicalId":37427,"journal":{"name":"Medeniyet medical journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/66/44/medj-38-16.PMC10064100.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9227881","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Observational Study of Pediatric Cochlear Implant Recipients: Two-year Follow-up Outcomes.","authors":"Sidika Cesur,&nbsp;Ayca Ciprut,&nbsp;Sengul Terlemez","doi":"10.4274/MMJ.galenos.2023.35305","DOIUrl":"https://doi.org/10.4274/MMJ.galenos.2023.35305","url":null,"abstract":"<p><strong>Objective: </strong>The aim of this study was to evaluate the improvements in quality of life and auditory performance via a descriptive report using patient-related outcomes measures in a group of children with cochlear implants (CI).</p><p><strong>Methods: </strong>This was a longitudinal and retrospective study based on the analysis of patient records of a total of 28 children with CI, 18 of whom had bilateral (64.3%) and 10 had unilateral (35.7%). The study included repeated within-subject measures of Hearing Implants Quality of Life (CuHI-QoL), Categories of Auditory Performance (CAP-II), Speech, Spatial, and Qualities of Hearing scale-Parents' version (SSQ-P) scales, and Implant Recipient Follow-up (IRF) form at 6-month intervals from baseline up to 24 months.</p><p><strong>Results: </strong>During the 2-year follow-up assessments, all children with CI showed statistically significant improvement over time in their CAPII, SSQ-P, CuHI-QoL, and IRF scores (p<0.001). The most significant increase in scores occurred within the first six months following the baseline and then continued to increase gradually at a slower pace over time. A moderate negative relationship was found between the age of implantation and SSQ-P and family satisfaction scores of IRF (p<0.05).</p><p><strong>Conclusions: </strong>Family expectations, overall well-being, quality of life, auditory, and verbal skills increase positively with earlier CI intervention. Moreover, the subjective assessment results showed that parents-positive attitudes toward implantation, and willingness to recommend it to others have steadily increased in time. Although the cohort is relatively small and variable, the results offer a descriptive view to outcomes in real-world practice.</p>","PeriodicalId":37427,"journal":{"name":"Medeniyet medical journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/4a/af/medj-38-78.PMC10064103.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9239564","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Does Apoptotic Index Predict the Response to Neoadjuvant Chemotherapy in Patients with Breast Carcinoma?","authors":"Gokce Askan,&nbsp;Oguzhan Okcu,&nbsp;Cigdem Ozturk,&nbsp;Seda Duman Ozturk,&nbsp;Bayram Sen,&nbsp;Recep Bedir","doi":"10.4274/MMJ.galenos.2022.59196","DOIUrl":"https://doi.org/10.4274/MMJ.galenos.2022.59196","url":null,"abstract":"<p><strong>Objective: </strong>Neoadjuvant chemotherapy (NACT) plays a major role in the treatment of patients with locally advanced breast carcinoma. Although most patients have benefited from NACT, the rate of residual tumors is still high after treatment (AT). An increase in apoptosis is expected in tru-cut biopsy (TCB) during treatment or AT as the mechanism of NACT is inducing apoptosis. This study aimed to investigate whether evaluating the apoptotic index (AI) from TCB can predict the response before treatment (TC-BT) and whether there is a correlation between AI and clinicopathologic parameters.</p><p><strong>Methods: </strong>Seventy cases of breast carcinomas were included. The AI was evaluated BT and AT by quantifying the apoptosis. The receiver operating characteristic analysis was performed with overall survival (OS) data, and low and high AI cut-offs were obtained. The relationship between AI and response and clinicopathological parameters was evaluated.</p><p><strong>Results: </strong>A significant relationship was found between low AI in TC-BT and at least partial response (p=0.025), longer OS (p=0.01) and disease-free survival (p=0.01), and progesterone receptor-positive tumors (p=0.03). Her2-negative tumors were more prone to low AI. A significant decline in AI (p=0.001) and Ki67 proliferation index (p<0.001) was observed in resections AT.</p><p><strong>Conclusions: </strong>These data suggested that the AI is a simple and cost-effective tool that may play an important role in determining response, and a low AI in TC-BT may have some value as a predictive marker in breast carcinomas.</p>","PeriodicalId":37427,"journal":{"name":"Medeniyet medical journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/75/21/medj-38-1.PMC10064109.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9227879","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Short-term Effectiveness of High-intensity Laser Therapy in De Quervain Tenosynovitis: A Prospective, Randomized, Controlled Study.","authors":"Emine Dundar Ahi,&nbsp;Hulya Sirzai","doi":"10.4274/MMJ.galenos.2023.67279","DOIUrl":"https://doi.org/10.4274/MMJ.galenos.2023.67279","url":null,"abstract":"<p><strong>Objective: </strong>The effectiveness of high-intensity laser therapy (HILT) has been demonstrated in some musculoskeletal repetitive strain injury disorders. This study aimed to determine the short-term effectiveness of HILT in de Quervain tenosynovitis (DQT).</p><p><strong>Methods: </strong>Sixty-four patients with DQT diagnosis (32 males, 32 females; 18-65 years) were randomly divided into two groups. A short opponens splint was applied to both groups and HILT to the treatment group and sham HILT to the control group once a day, on alternate days, 3 days a week, for 5 weeks. Pre- and post-treatment evaluations were made using a visual analog scale (VAS); Quick Disabilities of the Arm, Shoulder, and Hand questionnaire; Short Form-36 Health Survey; and hand grip strength test.</p><p><strong>Results: </strong>The demographic results (age, gender, duration of complaint, body mass index, occupational group) of both groups were similar (p>0.05). The pre-treatment measured values were similar in both groups (p>0.05). After a 5-week treatment, a significant improvement was observed in all parameters in both groups. Post-treatment, hand grip strength levels were statistically higher in the HILT group than in the sham therapy group, and VAS levels were significantly lower (p<0.001).</p><p><strong>Conclusions: </strong>HILT is a non-invasive and reliable method that increases grip strength and decreases pain in DQT.</p>","PeriodicalId":37427,"journal":{"name":"Medeniyet medical journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/3c/04/medj-38-24.PMC10064111.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9227883","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of Tools for Nutritional Assessment and Screening of Hospitalized Patients: A study on Surgical Patients.","authors":"Susetyowati Susetyowati,&nbsp;Amalia Sarah Sholikhati,&nbsp;Dinda Krisma Cahyaningrum,&nbsp;Azizah Isna Rachmawati,&nbsp;Adeodatus Yuda Handaya","doi":"10.4274/MMJ.galenos.2023.64554","DOIUrl":"https://doi.org/10.4274/MMJ.galenos.2023.64554","url":null,"abstract":"<p><strong>Objective: </strong>To compare the Simple Nutrition Screening Tool (SNST) with other nutritional screening tools [Nutrition Risk Screening 2002 (NRS-2002), Nutrition Risk index (NRI)], nutritional assessment parameters, and the Subjective Global Assessment (SGA) in surgical patients.</p><p><strong>Methods: </strong>A comparative observational study with a total of 122 surgical patients. Patients were assessed during the first 24 h of admission in the ward from January to July 2022 using the NRI, NRS-2002, SNST, body mass index (BMI), mid-upper arm circumferences (MUAC), albumin serum, hemoglobin level, total lymphocyte count (TLC), and SGA. Sensitivity, specificity and predictive values were calculated to evaluate NRI, NRS-2002, SNST, BMI, MUAC, albumin, hemoglobin, TLC compared to SGA.</p><p><strong>Results: </strong>The screening tools identified a high nutritional risk in surgical patients from 58.2%-72.1%. Meanwhile, about 29.5% to 71.3% was affected by malnutrition based on nutritional assessment tools. There were significant associations between the type of disease, the screening tools, the anthropometric parameters, albumin, TLC as well and SGA (p<0.05). The SNST has a good category among the nutritional screening tools with sensitivity and specificity >80%, as well as area under the curve >0.8.</p><p><strong>Conclusions: </strong>There were significant associations for screening (NRS-2002, SNST) and nutritional assessment tools (BMI, MUAC, albumin) compared with SGA. Both these tools can be used to determine the risk of malnutrition in surgical patients.</p>","PeriodicalId":37427,"journal":{"name":"Medeniyet medical journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/57/2b/medj-38-70.PMC10064107.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9239559","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Current Advances and Future Prospects in Cancer Immunotherapeutics.","authors":"Zeynep Dede,&nbsp;Kader Tumer,&nbsp;Tugce Kan,&nbsp;Burcu Yucel","doi":"10.4274/MMJ.galenos.2023.29599","DOIUrl":"https://doi.org/10.4274/MMJ.galenos.2023.29599","url":null,"abstract":"<p><p>Cancer is a disease that results from the uncontrolled proliferation and growth of cells. Due to early detection methods, there is a decrease in death rates in many types of cancer. However, among the causes of death worldwide, cancer still ranks second after cardiovascular diseases. Therefore, cancer research has focused mainly on developing more effective treatments to reduce deaths from cancer. With a better understanding of the molecular mechanisms in cancer cells, advances in cancer treatment have evolved and changed. The main priority of research is to develop treatment modalities with the highest response rate and less side effects. In this context, immunotherapies have started a new era in cancer treatments. In this review, an overview of the future of next-generation treatment methods is presented by including the most preferred immunotherapy methods.</p>","PeriodicalId":37427,"journal":{"name":"Medeniyet medical journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/70/92/medj-38-88.PMC10064104.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9239562","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Effect of Platelet and Mean Platelet Volume Levels on Standard-dose Methylprednisolone Treatment Response in Primary Immune Thrombocytopenia.","authors":"Emrah Kilicaslan,&nbsp;Murat Yildirim,&nbsp;Selim Sayin,&nbsp;Erdem Cevik,&nbsp;Meltem Ayli,&nbsp;Meltem Kaptan","doi":"10.4274/MMJ.galenos.2023.85520","DOIUrl":"https://doi.org/10.4274/MMJ.galenos.2023.85520","url":null,"abstract":"<p><strong>Objective: </strong>Standard-dose methyl-prednisolone (methyl-Pd) is generally preferred as the first-line treatment in immune thrombocytopenia (ITP) unless there is an urgent indication to increase the platelet value. A significant proportion of patients (around 40%) does not benefit from this treatment. This study investigated whether pretreatment platelet level and other hemogram indices in patients with ITP patients can be used to predict early response to standard-dose methyl-Pd treatment.</p><p><strong>Methods: </strong>Patients who received first-line standard-dose methyl- Pd therapy with the diagnosis of primary ITP were included. Patients were categorized as complete responder (CR), responder (R), and non-responder (NR) according to the response status obtained within the first 14 days of treatment. The hemogram indices of the CR, R, and NR groups measured at the start of the treatment were compared retrospectively.</p><p><strong>Results: </strong>One hundred forty four patients with ITP were included in the study. The number of patients with NR, R, and CR were 47 (33%), 40 (28%), and 57 (39%), respectively. The mean platelet level of the NR group was lower than responders (R and CR groups) (p=0.002 and p=0.049, respectively). The mean platelet volume (MPV) levels of the NR group were statistically lower than that of the CR group (p=0.018). If MPV ≥10 fL and platelet >12,000/mm³, the probability of an early response with methyl-Pd is higher [sensitivity =98.1% (95% confidence interval (CI) =89.7-99.9%), specificity =45% (95% CI =23.1-68.5%), positive predictive value =82.3% (95% CI =75.7-87.4%), negative predictive value =90% (95% CI =54.9-98.5%)].</p><p><strong>Conclusions: </strong>Patients with ITP with low platelet and MPV levels were less responsive to standard-dose methyl-Pd treatment. It may be more appropriate to apply more effective treatments to these patients other than standard-dose methyl-Pd alone.</p>","PeriodicalId":37427,"journal":{"name":"Medeniyet medical journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/dd/e8/medj-38-63.PMC10064110.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9222175","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lung Metastases to the Heart with Atypical Clinical Manifestations of Cardiac Failure.","authors":"Nataliia Hyriavenko,&nbsp;Vladyslav Sikora,&nbsp;Wireko Andrew Awuah,&nbsp;Toufik Abdul-Rahman,&nbsp;Mykola Lyndin,&nbsp;Anatolii Romaniuk","doi":"10.4274/MMJ.galenos.2023.13693","DOIUrl":"https://doi.org/10.4274/MMJ.galenos.2023.13693","url":null,"abstract":"<p><p>The heart is a rare site of cancer metastases, even from the most common malignancies, such as lung cancer. Cardiac metastases may lead to myocardial dysfunction. This report presents a case of lung cancer metastases to the left ventricular myocardium that clinically manifested as atypical symptoms of cardiac dysfunction. The metastases were not revealed until after the patient died. Posthumously, the anamnesis, autopsy results, and morphological examination were evaluated. We demonstrated that the atypical symptoms of cardiac dysfunction were caused by occult (undiagnosed) metastases of lung cancer cells to the heart. The doctors did not consider this variant as possible metastatic lung cancer, because the patient had been treated radically one year earlier.</p>","PeriodicalId":37427,"journal":{"name":"Medeniyet medical journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/66/cc/medj-38-95.PMC10064108.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9239563","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Does Postpartum Psychosis Have a Cultural Aspect?","authors":"Pınar Sivrikaya,&nbsp;Cicek Hocaoglu","doi":"10.4274/MMJ.galenos.2023.72929","DOIUrl":"https://doi.org/10.4274/MMJ.galenos.2023.72929","url":null,"abstract":"","PeriodicalId":37427,"journal":{"name":"Medeniyet medical journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/bf/d2/medj-38-100.PMC10064102.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9222177","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}