Chem最新文献

{"title":"Opportunities for merging biosynthesis and biocatalysis","authors":"Dongshan Wu, Jin Wang, Xiaoguang Lei","doi":"10.1016/j.chempr.2026.103254","DOIUrl":"10.1016/j.chempr.2026.103254","url":null,"abstract":"<div>Biosynthesis and biocatalysis are converging to reshape the landscape of sustainable chemistry. While natural product biosynthesis has long served as a window into nature’s synthetic logic, its true potential as a reservoir of powerful biocatalysts remains underexplored, and many synthetically valuable transformations still lack efficient biocatalytic solutions. Translating these natural enzymes into practical biocatalysts requires overcoming challenges in stability, substrate scope, and catalytic efficiency. The convergence of these two fields—enabled by advances in enzyme discovery, directed evolution, and artificial intelligence—offers unprecedented opportunities to unlock powerful biocatalysts and reprogram existing enzymes for non-natural functions. Furthermore, the merging of biosynthesis and biocatalysis also redefines how we discover, characterize, and deploy enzymes—shifting from molecule-centric discovery toward function-driven biocatalyst development. The future lies in harnessing nature’s catalytic diversity to address long-standing synthetic challenges, paving the way for a more sustainable chemical industry.</div><div><div>The convergence of biosynthesis and biocatalysis is unlocking a new paradigm for the efficient construction of functional molecules, such as natural products and pharmaceuticals. By elucidating biosynthetic pathways, including all valuable enzymatic transformations that originate from biological systems, chemists can directly access powerful natural enzymes or engineer them via directed evolution to address long-standing synthetic challenges. This perspective explores the synergistic opportunities arising from integrating biosynthesis and biocatalysis. We highlight how enzymes derived from natural product biosynthetic pathways—such as Diels-Alderases—and tailored enzymes serve as powerful biocatalytic tools, with their utility further expanded through protein engineering. This convergence, by merging nature’s biosynthetic logic with modern chemo-catalytic concepts, enables new-to-nature reactivities. We further discuss how unmet synthetic demands are reshaping biosynthetic research, driving the discovery of enzymes with novel catalytic functions. We conclude by outlining future directions, including AI-driven enzyme discovery and engineering, as well as automated high-throughput experimentation, which will accelerate the translation of these integrating approaches into scalable and sustainable manufacturing solutions.</div></div><div>The convergence of biosynthesis and biocatalysis is unlocking a new paradigm for the efficient construction of functional molecules, such as natural products and pharmaceuticals. By elucidating biosynthetic pathways, including all valuable enzymatic transformations that originate from biological systems, chemists can directly access powerful natural enzymes or engineer them via directed evolution to address long-standing synthetic challenges. This perspective explores the synergi","PeriodicalId":268,"journal":{"name":"Chem","volume":"12 10","pages":"Article 103254"},"PeriodicalIF":19.1,"publicationDate":"2026-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149125240","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Synthesis and optimization of ionizable lipids for RNA delivery","authors":"Bowen Wu, Xuehe Lu, Marshall S. Padilla, Ether Dharmesh, Ying Xu, Michael J. Mitchell, Xuexiang Han","doi":"10.1016/j.chempr.2026.103244","DOIUrl":"10.1016/j.chempr.2026.103244","url":null,"abstract":"<div>The dawn of the RNA era has redefined modern medicine, with lipid nanoparticles (LNPs) serving as the key delivery platform that overcomes multiple biological barriers for successful RNA delivery. Within the LNP architecture, ionizable lipids play a central role: they not only govern nanoparticle assembly and stability but also directly regulate essential biological processes such as endosomal escape, organ tropism, and biosafety. This review examines the design, synthesis, and optimization of ionizable lipids from a chemist’s perspective, framing them as a highly tunable and modular platform. By deconstructing their architecture into three core components—headgroup, linker, and tail—we illustrate how precise molecular engineering modulates properties such as p<em>K</em><sub>a</sub>, lipophilicity, and fusogenicity, thereby influencing delivery efficiency and tissue selectivity. The integration of combinatorial chemistry, high-throughput screening, and machine-learning-aided prediction is now accelerating the development of ionizable lipids, shifting the field from empirical optimization toward increasingly systematic and target-oriented design. Ultimately, deeper insights into structure-performance relationships, together with the integration of interdisciplinary methodologies, will further enable ionizable lipids to expand the use of RNA therapeutics across diverse applications, including gene editing and cancer immunotherapy, laying a material foundation for the next generation of precision medicine.</div><div><div>Lipid nanoparticles (LNPs), as the leading non-viral system for RNA delivery, have significantly advanced the clinical development of RNA vaccines and therapeutics. Among the four classical components, ionizable lipids are the most critical ones and largely determine the safety and performance of LNPs. Ionizable lipids typically consist of an ionizable headgroup, linkers, and hydrophobic tails, and subtle changes in each moiety can lead to dramatic variations in encapsulation efficiency, transfection potency, biocompatibility, and cell/organ tropism. In this review, we summarize the recent progress in ionizable lipids, underscoring key advances in their chemical synthesis, structural refinement, and functional improvements. Meanwhile, we present an overview of the major achievements of ionizable lipids, with a focus on their clinical applications. Finally, we discuss current limitations of ionizable lipids and propose potential solutions.</div></div><div>Lipid nanoparticles (LNPs), as the leading non-viral system for RNA delivery, have significantly advanced the clinical development of RNA vaccines and therapeutics. Among the four classical components, ionizable lipids are the most critical ones and largely determine the safety and performance of LNPs. Ionizable lipids typically consist of an ionizable headgroup, linkers, and hydrophobic tails, and subtle changes in each moiety can lead to dramatic variations in encapsulation e","PeriodicalId":268,"journal":{"name":"Chem","volume":"12 10","pages":"Article 103244"},"PeriodicalIF":19.1,"publicationDate":"2026-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149125242","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chasing nature’s anion binders","authors":"Junhong Li, Martin Stroet, Vivian G. Shang, Wenrui Lyu, Jack K. Clegg, Evelyne Deplazes, Xin Wu","doi":"10.1016/j.chempr.2026.103036","DOIUrl":"10.1016/j.chempr.2026.103036","url":null,"abstract":"<div><ul><li><span>•</span><span><div>Development of uncharged molecular cages with highly pre-organized urea sites</div></span></li><li><span>•</span><span><div>Neutral hydrogen bonds achieve micromolar affinities for hydrophilic anions</div></span></li><li><span>•</span><span><div>A cage-integrated ionic liquid selectively captures chromate and sulfate from water</div></span></li></ul></div><div>Sulfate-binding proteins from bacteria capture strongly hydrated sulfate anions from the environment as an initial step of nutrient uptake. Surprisingly, their interaction with sulfate is purely hydrogen bonding, without the formation of salt links, yet achieves remarkable sub-micromolar affinities. Supramolecular chemists have faced significant challenges in using hydrogen bonds to attain comparable host-guest binding strengths in water. In this work, the authors demonstrate that highly pre-organized, charge-neutral urea cages can bind hydrophilic chloride, sulfate, and chromate anions with micromolar affinities in water, even though the urea sites are exposed to water such that significant energetic penalties from host dehydration have reduced the overall binding strength. In addition, an ionic liquid material integrating a thiourea cage is shown to remove chromate and sulfate anions selectively in complex water samples, highlighting its real-world applicability. In the future, the design principles used in this work open opportunities to create larger hydrogen-bonding host architectures to recognize more complex biological targets, such as peptides and proteins, toward applications in targeted delivery, biological sensing, and therapeutic intervention.</div><div><div>In water, hydrogen bonds between solute molecules are disfavored because they must compete with the overwhelming abundance of water forming hydrogen bonds with solutes. Thus, molecular recognition by hydrogen bonds in water has long been considered challenging, often requiring auxiliary interactions such as ion pairing and hydrophobic contacts. Yet through evolved structural sophistication, certain biological receptors such as sulfate-binding proteins use hydrogen bonds alone to bind hydrophilic anions with remarkable (sub)micromolar affinities. Here, we report highly pre-organized, uncharged hydrogen-bonding molecular cages that match the micromolar affinities of nature’s anion receptors in water. Contrasting large biological receptors that bury polar binding sites within hydrophobic cores, these synthetic hosts have just 52 heavy atoms with polar binding sites exposed to water. These results establish the capabilities of unshielded polar hydrogen bonds in aqueous supramolecular chemistry, providing new opportunities for biological interventions and molecular separations.</div></div><div>In water, hydrogen bonds between solute molecules are disfavored because they must compete with the overwhelming abundance of water forming hydrogen bonds with solutes. Thus, molecular recognition by hy","PeriodicalId":268,"journal":{"name":"Chem","volume":"12 10","pages":"Article 103036"},"PeriodicalIF":19.1,"publicationDate":"2026-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147709284","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Looking back to move polymer chemistry forward","authors":"Kostas Parkatzidis","doi":"10.1016/j.chempr.2026.103288","DOIUrl":"10.1016/j.chempr.2026.103288","url":null,"abstract":"<div><div><span><figure><span><img><ol><li><span><span>Download: <span>Download high-res image (162KB)</span></span></span></li><li><span><span>Download: <span>Download full-size image</span></span></span></li></ol></span></figure></span>Kostas Parkatzidis is an assistant professor in the Department of Chemistry at Stockholm University, where he established the Sustainable Polymer Chemistry (SPC) Lab in 2026. He earned his PhD from ETH Zurich, where he worked on controlled radical polymerization and depolymerization, and subsequently conducted postdoctoral research at Stanford University on advanced polymer architectures and functional soft materials. His group develops new approaches in sustainable polymer chemistry by integrating polymer synthesis and molecular architecture with chemical recycling and material fabrication.</div></div><div><span><figure><span><img><ol><li><span><span>Download: <span>Download high-res image (162KB)</span></span></span></li><li><span><span>Download: <span>Download full-size image</span></span></span></li></ol></span></figure></span>Kostas Parkatzidis is an assistant professor in the Department of Chemistry at Stockholm University, where he established the Sustainable Polymer Chemistry (SPC) Lab in 2026. He earned his PhD from ETH Zurich, where he worked on controlled radical polymerization and depolymerization, and subsequently conducted postdoctoral research at Stanford University on advanced polymer architectures and functional soft materials. His group develops new approaches in sustainable polymer chemistry by integrating polymer synthesis and molecular architecture with chemical recycling and material fabrication.</div>","PeriodicalId":268,"journal":{"name":"Chem","volume":"12 10","pages":"Article 103288"},"PeriodicalIF":19.1,"publicationDate":"2026-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149124099","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The recycle reality: A process-level perspective on catalytic CO2 hydrogenation to methanol","authors":"Lukas Spiekermann,&nbsp;Thaylan Pinheiro Araújo,&nbsp;Tangsheng Zou,&nbsp;Jan Seiler,&nbsp;Benedikt Winter,&nbsp;Javier Pérez-Ramírez,&nbsp;André Bardow","doi":"10.1016/j.chempr.2026.103264","DOIUrl":"10.1016/j.chempr.2026.103264","url":null,"abstract":"&lt;div&gt;The transition to a sustainable chemical industry hinges on CO&lt;sub&gt;2&lt;/sub&gt; hydrogenation as the cornerstone of the methanol economy. However, progress is currently slowed by a disciplinary divide: catalyst innovation and process engineering frequently advance in isolation. This siloed approach leads to catalysts that may fail under industrial constraints and process designs that rely on outdated chemical knowledge.&lt;/div&gt;&lt;div&gt;Achieving cost-effective and climate-friendly methanol production requires a paradigm shift, moving beyond sequential development toward a system-level approach that accounts for thermodynamic constraints and industrial operating realities. Only through this synergy can we accelerate the deployment of CO&lt;sub&gt;2&lt;/sub&gt; utilization technologies at the scale required to mitigate climate change.&lt;/div&gt;&lt;div&gt;&lt;div&gt;Bridging the gap between molecular-level catalyst innovation and system-level process engineering is critical for the large-scale implementation of CO&lt;sub&gt;2&lt;/sub&gt; utilization. This perspective demonstrates that traditional catalyst benchmarking, conducted using stoichiometric feeds, suffers from a recycle-reality mismatch: in industrial-scale processes, large recycle loops dominate the reactor inlet, creating highly non-stoichiometric, CO-rich feeds and shifting the thermodynamic equilibrium. Meanwhile, process models rely on outdated kinetics extrapolated into unvalidated regimes. By integrating techno-economic analysis and life-cycle assessments across four catalyst families (Cu/ZnO/Al&lt;sub&gt;2&lt;/sub&gt;O&lt;sub&gt;3&lt;/sub&gt;, In&lt;sub&gt;2&lt;/sub&gt;O&lt;sub&gt;3&lt;/sub&gt;, InCo, and ZnZrO&lt;sub&gt;x&lt;/sub&gt;), we derive experimental catalyst-testing conditions and process performance metrics that reflect large-scale operations. We benchmark current catalytic performance and identify trade-offs between intrinsic activity, long-term stability, and the environmental burden of critical metal depletion. Finally, we propose an iterative catalytic process development cycle to align fundamental research with industrial deployment, accelerating the translation of catalytic breakthroughs into viable solutions for a sustainable chemical industry.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;Bridging the gap between molecular-level catalyst innovation and system-level process engineering is critical for the large-scale implementation of CO&lt;sub&gt;2&lt;/sub&gt; utilization. This perspective demonstrates that traditional catalyst benchmarking, conducted using stoichiometric feeds, suffers from a recycle-reality mismatch: in industrial-scale processes, large recycle loops dominate the reactor inlet, creating highly non-stoichiometric, CO-rich feeds and shifting the thermodynamic equilibrium. Meanwhile, process models rely on outdated kinetics extrapolated into unvalidated regimes. By integrating techno-economic analysis and life-cycle assessments across four catalyst families (Cu/ZnO/Al&lt;sub&gt;2&lt;/sub&gt;O&lt;sub&gt;3&lt;/sub&gt;, In&lt;sub&gt;2&lt;/sub&gt;O&lt;sub&gt;3&lt;/sub&gt;, InCo, and ZnZrO&lt;sub&gt;x&lt;/sub&gt;), we derive experimental catalyst-testing co","PeriodicalId":268,"journal":{"name":"Chem","volume":"12 10","pages":"Article 103264"},"PeriodicalIF":19.1,"publicationDate":"2026-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149125241","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Solvent-mediated electrochemical acetylene semihydrogenation for continuous production of polymer-grade ethylene","authors":"Xuxu Wang,&nbsp;Wenqian Chen,&nbsp;Xiaojia Lei,&nbsp;Xin Wang,&nbsp;Chao Lei,&nbsp;Qianqian Xie,&nbsp;Yongyou Hu,&nbsp;Yi-Ge Zhou,&nbsp;Tiefeng Wang,&nbsp;Jian Zhang,&nbsp;Binbin Huang","doi":"10.1016/j.chempr.2026.103063","DOIUrl":"10.1016/j.chempr.2026.103063","url":null,"abstract":"&lt;div&gt;&lt;ul&gt;&lt;li&gt;&lt;span&gt;•&lt;/span&gt;&lt;span&gt;&lt;div&gt;A solvent-mediated electrochemical acetylene hydrogenation approach is reported&lt;/div&gt;&lt;/span&gt;&lt;/li&gt;&lt;li&gt;&lt;span&gt;•&lt;/span&gt;&lt;span&gt;&lt;div&gt;Solvent absorption of acetylene is coupled with &lt;em&gt;in situ&lt;/em&gt; electrochemical conversion&lt;/div&gt;&lt;/span&gt;&lt;/li&gt;&lt;li&gt;&lt;span&gt;•&lt;/span&gt;&lt;span&gt;&lt;div&gt;This approach follows the proton-coupled electron-transfer mechanism&lt;/div&gt;&lt;/span&gt;&lt;/li&gt;&lt;li&gt;&lt;span&gt;•&lt;/span&gt;&lt;span&gt;&lt;div&gt;Long-term stability is achieved with a common Cu electrode&lt;/div&gt;&lt;/span&gt;&lt;/li&gt;&lt;/ul&gt;&lt;/div&gt;&lt;div&gt;Reducing carbon emissions at the source is the most important strategy for accomplishing carbon neutrality. With an annual production of more than 200 million metric tons, ethylene is the most widely used chemical feedstock for producing essential polymeric products, such as polyethylene and rubber. However, its purification from a petroleum-based process (e.g., thermocatalytic acetylene hydrogenation) and its production from a coal-based process (e.g., Fischer-Tropsch synthesis) normally require high temperature, high pressure, and gaseous hydrogen, inevitably resulting in high energy consumption, high carbon emissions, and low ethylene selectivity. Electrocatalytic acetylene semihydrogenation offers a sustainable route for polymer-grade ethylene production. However, this approach relies on a complex gas diffusion electrode and electrolytic operation, which leads to the fundamental issues of long-term stability and scalability. Here, by combining solvent absorption of acetylene with &lt;em&gt;in situ&lt;/em&gt; electrochemical hydrogenation, we provide an alternative electrochemical approach to simultaneously address the fundamental challenges of both electrocatalytic acetylene hydrogenation and solvent-absorption methods. This study offers green routes for ethylene purification from petroleum-based lines and for ethylene production from coal-based lines and opens up a new avenue for the development of electrochemical alkyne hydrogenation technologies. This study can bring technological innovation to the petrochemical and coal-chemical fields and contribute to the reduction of CO&lt;sub&gt;2&lt;/sub&gt; emissions on a global scale.&lt;/div&gt;&lt;div&gt;&lt;div&gt;The purification of crude ethylene is an energy-intensive process facing the challenges of high temperature, poor stability, and low ethylene selectivity. Here, we report a solvent-mediated electrochemical acetylene semihydrogenation approach that operates under mild conditions by exploiting differences in solvent absorption between acetylene and ethylene without solvent loss. This strategy significantly enhances the selective dissolution and diffusion of acetylene impurities to the cathode surface and drives their rapid hydrogenation to ethylene at the electron- and proton-rich liquid-solid interface. Over a 200-h continuous-flow stability test, the conversion of acetylene to ethylene remained at ∼100% with an ethylene selectivity of &gt;99% and residual acetylene of &lt;5 ppm under a crude ethylene stream. Theoretical, physic","PeriodicalId":268,"journal":{"name":"Chem","volume":"12 10","pages":"Article 103063"},"PeriodicalIF":19.1,"publicationDate":"2026-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149125340","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unstabilized radicals find their direction","authors":"Miquel Costas","doi":"10.1016/j.chempr.2026.103255","DOIUrl":"10.1016/j.chempr.2026.103255","url":null,"abstract":"<div><div>Liu and co-workers report a ligand-mediated radical orientation strategy for the copper-catalysed asymmetric cyanation of non-stabilized alkyl radicals. A hydroxyl-functionalized ligand recognizes a remote polar group on the substrate, creating a catalyst-substrate ensemble that changes the kinetic paradigm of radical capture and C–CN bond formation, enabling enantioselective difunctionalization of alkenes and cyanation of sp³ C–H bonds.</div></div><div>Liu and co-workers report a ligand-mediated radical orientation strategy for the copper-catalysed asymmetric cyanation of non-stabilized alkyl radicals. A hydroxyl-functionalized ligand recognizes a remote polar group on the substrate, creating a catalyst-substrate ensemble that changes the kinetic paradigm of radical capture and C–CN bond formation, enabling enantioselective difunctionalization of alkenes and cyanation of sp³ C–H bonds.</div>","PeriodicalId":268,"journal":{"name":"Chem","volume":"12 10","pages":"Article 103255"},"PeriodicalIF":19.1,"publicationDate":"2026-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149124098","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Active-site nanoconfinement for prolonged radical reactivity","authors":"Adeel Mehmood,&nbsp;Bing Wang,&nbsp;Jiadong Xiao","doi":"10.1016/j.chempr.2026.103213","DOIUrl":"10.1016/j.chempr.2026.103213","url":null,"abstract":"<div><div>Recently in <em>One Earth</em>, Xu and colleagues localized iron single atoms within Zeolite Socony Mobil-5 (ZSM-5) micropores to chemically anchor hydroxyl radicals via interfacial orbital hybridization, thereby extending lifespans 30-fold for continuous-flow water purification. Coupling this architecture with renewable-energy cascades and topographic cage effects holds great promise for unlocking sustainable pathways toward broad, selective chemical synthesis.</div></div><div>Recently in <em>One Earth</em>, Xu and colleagues localized iron single atoms within Zeolite Socony Mobil-5 (ZSM-5) micropores to chemically anchor hydroxyl radicals via interfacial orbital hybridization, thereby extending lifespans 30-fold for continuous-flow water purification. Coupling this architecture with renewable-energy cascades and topographic cage effects holds great promise for unlocking sustainable pathways toward broad, selective chemical synthesis.</div>","PeriodicalId":268,"journal":{"name":"Chem","volume":"12 10","pages":"Article 103213"},"PeriodicalIF":19.1,"publicationDate":"2026-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149124083","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The legacy of Masaya Sawamura: A journey through chiral space","authors":"Hajime Ito,&nbsp;Kenji Hara,&nbsp;Hirohisa Ohmiya,&nbsp;Tomohiro Iwai,&nbsp;Yohei Shimizu,&nbsp;Kosuke Higashida,&nbsp;Yusuke Masuda","doi":"10.1016/j.chempr.2026.103263","DOIUrl":"10.1016/j.chempr.2026.103263","url":null,"abstract":"<div><div>This memorial article honors the life and scientific legacy of Prof. Masaya Sawamura (1961–2026) of Hokkaido University. He opened new horizons in transition-metal-catalyzed reactions, from pioneering the gold(I)-catalyzed asymmetric aldol reaction to developing original ligands, such as <em>trans</em>-chelating TRAP, caged SMAP, “holey” triethynylphosphines, and various proline-based ligands. Beyond his world-class research achievements, he is remembered as a devoted mentor who cherished his students, the chemistry community, and the natural beauty of Hokkaido.</div></div><div>This memorial article honors the life and scientific legacy of Prof. Masaya Sawamura (1961–2026) of Hokkaido University. He opened new horizons in transition-metal-catalyzed reactions, from pioneering the gold(I)-catalyzed asymmetric aldol reaction to developing original ligands, such as <em>trans</em>-chelating TRAP, caged SMAP, “holey” triethynylphosphines, and various proline-based ligands. Beyond his world-class research achievements, he is remembered as a devoted mentor who cherished his students, the chemistry community, and the natural beauty of Hokkaido.</div>","PeriodicalId":268,"journal":{"name":"Chem","volume":"12 10","pages":"Article 103263"},"PeriodicalIF":19.1,"publicationDate":"2026-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149124086","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cluster-enabled control of single-electron photoredox catalysis in reticular frameworks","authors":"Clara Chinchilla-Garzón,&nbsp;Eva Rivera-Chao,&nbsp;Miguel Gomez-Mendoza,&nbsp;Bruno J.C. Vieira,&nbsp;Neyvis Almora-Barrios,&nbsp;Pol Gimeno-Fonquernie,&nbsp;Javier Castells-Gil,&nbsp;Rebecca Vismara,&nbsp;Jan Navrátil,&nbsp;Piotr Błoński,&nbsp;Víctor A. de la Peña O’Shea,&nbsp;João C. Waerenborgh,&nbsp;Carlos Martí-Gastaldo,&nbsp;Natalia M. Padial","doi":"10.1016/j.chempr.2026.103074","DOIUrl":"10.1016/j.chempr.2026.103074","url":null,"abstract":"<div><div>Photoredox catalysis has emerged as a powerful strategy for promoting redox reactions under mild conditions, but its translation from homogeneous to heterogeneous catalysts in porous solids remains limited. Metal-organic frameworks (MOFs) offer unique opportunities to bridge this gap by combining tailorable photoactive architectures with high stability, large surface areas, and modular control over reactivity via component selection. Despite recent progress, most photocatalytic MOF-based systems have focused on water splitting or CO₂ reduction, whereas applications in organic synthesis remain virtually unexplored. Here, we report a titanium-iron MOF (MUV-1001) built from heterometallic TiFe₂ metal-oxo clusters that operates as an intrinsically active visible-light photoredox catalyst. This platform enables single-electron transfer reactivity under irradiation, as demonstrated in a decarboxylative Giese reaction, and it represents an example of noble-metal- and additive-free C–C bond formation mediated by a pristine crystalline reticular material. Our findings highlight the potential of cluster-based design to access intrinsically photoactive systems, where subtle changes in composition dictate reactivity, even across isostructural families.</div></div>","PeriodicalId":268,"journal":{"name":"Chem","volume":"12 9","pages":"Article 103074"},"PeriodicalIF":19.1,"publicationDate":"2026-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148624252","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}