IF 19.6 1区化学

Chem Pub Date : 2026-03-12 Epub Date: 2026-02-23 DOI: 10.1016/j.chempr.2026.102969

Carsten Streb

引用次数: 0

From “heavy” water to “heavy” boron clusters 从“重”水到“重”硼团簇

IF 19.6 1区化学

Chem Pub Date : 2026-03-12 Epub Date: 2026-02-27 DOI: 10.1016/j.chempr.2026.102995

Varun Tej Raviprolu , Alexander M. Spokoyny

引用次数: 0

Proton-coupled electrochemical reduction of a phosphine oxide 质子耦合电化学还原氧化膦

IF 23.5 1区化学

Chem Pub Date : 2026-03-10 DOI: 10.1016/j.chempr.2026.102946

Aragorn Laverny, Hai-Xu Wang, Gregory Valtierra, Maximilian D. Palkowitz, Gregory L. Beutner, Michael D. Mandler, Yingchuan Zhu, Peter Müller, Paul M. Scola, Yogesh Surendranath, Alexander T. Radosevich

{"title":"Proton-coupled electrochemical reduction of a phosphine oxide","authors":"Aragorn Laverny, Hai-Xu Wang, Gregory Valtierra, Maximilian D. Palkowitz, Gregory L. Beutner, Michael D. Mandler, Yingchuan Zhu, Peter Müller, Paul M. Scola, Yogesh Surendranath, Alexander T. Radosevich","doi":"10.1016/j.chempr.2026.102946","DOIUrl":"https://doi.org/10.1016/j.chempr.2026.102946","url":null,"abstract":"The two-proton/two-electron electrochemical reduction of a phosphine oxide with elimination of water as the sole byproduct (P(V)=O + 2H+ + 2e− → P(III) + H2O) is reported. Under electrochemical (constant current electrolysis) conditions, reduction of 5-phenylphospholo[3,2-c:4,5-c']dipyridine P-oxide (1O) in the presence of a proton donor gives the corresponding phosphine (1) in up to 90% yield and 95% conversion. Electrokinetic data and simulations are consistent with an ErCiErCi mechanism, in which an initial one-electron reduction brings about rate-limiting protonation of the phosphoryl bond. A regioisomeric phosphine oxide (9-phenylphospholo[2,3-c:5,4-c']dipyridine P-oxide, 2O) shows reversible electron transfer (ET) behavior but does not lead to proton-coupled electron transfer (PCET) P=O reduction. These results introduce the electronic design of π-substituents as a tunable mode for accessing the previously challenging proton-coupled reduction of the strong P=O bond.","PeriodicalId":268,"journal":{"name":"Chem","volume":"76 1","pages":""},"PeriodicalIF":23.5,"publicationDate":"2026-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147393698","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Splint RNA-mediated single-stranded DNA-encoded library construction and label-free live-cell selection 夹板rna介导的单链dna编码文库构建和无标记活细胞选择

IF 23.5 1区化学

Chem Pub Date : 2026-03-10 DOI: 10.1016/j.chempr.2026.102945

Jie Li, Ying Yao, Shuning Zhang, Wei Wang, Wanting Bi, Jian Lv, Wei Hou, Peixiang Ma, Hongtao Xu

{"title":"Splint RNA-mediated single-stranded DNA-encoded library construction and label-free live-cell selection","authors":"Jie Li, Ying Yao, Shuning Zhang, Wei Wang, Wanting Bi, Jian Lv, Wei Hou, Peixiang Ma, Hongtao Xu","doi":"10.1016/j.chempr.2026.102945","DOIUrl":"https://doi.org/10.1016/j.chempr.2026.102945","url":null,"abstract":"To address the challenges associated with the construction and selection of single-stranded DNA-encoded libraries (ssDELs), an efficient and precise short-splint RNA-mediated single-stranded DNA (ssDNA) ligation system has been developed. This system exhibits superior discrimination of single-base mismatches at oligonucleotide ligation junctions and requires only 12–14 nucleotides to achieve optimal ligation. By leveraging these advantages, we have established a concise ssDEL-encoding platform, as evidenced by the efficient synthesis and selection of pilot libraries ranging from 104 to 2.95 × 106 members. Additionally, capitalizing on the high sensitivity of this ligation system, a SplintR ligase-mediated proximity ligation (SIMPL)-based polymerase chain reaction (PCR) method has been developed. This method achieves remarkable sensitivity, enabling the linking of chemical and phenotypic information at detection limits as low as zeptomole levels. This capability facilitates significant hit enrichment ratios and enables the identification of a novel carbonic anhydrase XII (CAXII) binder with picomolar affinity through label-free, live-cell-based ssDEL selection.","PeriodicalId":268,"journal":{"name":"Chem","volume":"82 1","pages":""},"PeriodicalIF":23.5,"publicationDate":"2026-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147393697","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

SAM molecular stacking with heterogeneous orientation for high-performance perovskite photovoltaics 高性能钙钛矿光伏材料中具有异质取向的SAM分子堆积

IF 23.5 1区化学

Chem Pub Date : 2026-03-05 DOI: 10.1016/j.chempr.2026.102941

Lei Huang, Kai-Li Wang, Zhang Chen, Zhen-Huang Su, Saidjafar Murodzoda, Xin Chen, Jing Chen, Chun-Hao Chen, Yu Xia, Yu-Tong Yang, Jia-Cheng Li, Dilshod Nematov, Ilhan Yavuz, Zhao-Kui Wang

{"title":"SAM molecular stacking with heterogeneous orientation for high-performance perovskite photovoltaics","authors":"Lei Huang, Kai-Li Wang, Zhang Chen, Zhen-Huang Su, Saidjafar Murodzoda, Xin Chen, Jing Chen, Chun-Hao Chen, Yu Xia, Yu-Tong Yang, Jia-Cheng Li, Dilshod Nematov, Ilhan Yavuz, Zhao-Kui Wang","doi":"10.1016/j.chempr.2026.102941","DOIUrl":"https://doi.org/10.1016/j.chempr.2026.102941","url":null,"abstract":"The inability to achieve uniform hole transport with solution-processed self-assembled monolayers (SAMs) constitutes a fundamental bottleneck for scaling perovskite photovoltaics. Herein, we demonstrate that thermal-evaporated SAMs (eSAMs) overcome this limitation by enabling precise thickness control. Crucially, a thickened eSAM spontaneously forms a vertical-to-horizontal gradient in molecular orientation, which creates a descending energy barrier that directionally facilitates hole transport. This tailored interface also ensures excellent surface coverage and directs the growth of high-quality perovskite films. Consequently, the resultant photovoltaic devices set new benchmarks, delivering impressive power conversion efficiencies (PCEs) of 21.46% (small-area, 0.108 cm2) and 19.38% (large-area module, 15.52 cm2) for fully vacuum-evaporated devices, while also setting an impressive PCE of 23.67% for eSAM-based devices with solution-processed perovskites. This new strategy effectively addresses the critical challenge of scalable SAM deposition, positioning eSAM as a key enabler for the industrial advancement of perovskite photovoltaics.","PeriodicalId":268,"journal":{"name":"Chem","volume":"290 1","pages":""},"PeriodicalIF":23.5,"publicationDate":"2026-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147360227","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Inorganic backbone polymer 无机骨架聚合物

IF 23.5 1区化学

Chem Pub Date : 2026-03-05 DOI: 10.1016/j.chempr.2026.102940

Xiaoya Wang, Qingda Liu, Xun Wang

{"title":"Inorganic backbone polymer","authors":"Xiaoya Wang, Qingda Liu, Xun Wang","doi":"10.1016/j.chempr.2026.102940","DOIUrl":"https://doi.org/10.1016/j.chempr.2026.102940","url":null,"abstract":"The field of polymer science has long been dominated by carbon-based backbone structures. Although traditional inorganic material-based polymers have found applications in specific areas, their diversity in composition and structure remains limited. This perspective introduces the concept of inorganic backbone polymers, which are polymer analogs whose backbones consist of inorganic materials, assisted by organic ligands for structural assembly and stabilization. This definition transcends the boundaries of classical organic polymers and traditional inorganic polymers. Here, we will elaborate on how the methods, represented by liquid-phase synthesis strategies, enable precise control over the composition and structure of such materials at the sub-nanometer scale. Furthermore, we will discuss how the interfacial engineering strategies, such as the utilization of dynamic covalent bonds, can impart macroscopic processability and functionality to these materials. Inorganic backbone polymers combine the advantages of an inorganic backbone core and polymer-like topology, endowing them with unique properties and application prospects in fields such as mechanics, optics, and catalysis. This article aims to introduce this emerging field of inorganic backbone polymers, showcase their strategic shift from serendipitous discovery toward rational design, and elucidate the potential to redefine the frontiers of polymer science and nanomaterial chemistry.","PeriodicalId":268,"journal":{"name":"Chem","volume":"14 1","pages":""},"PeriodicalIF":23.5,"publicationDate":"2026-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147360100","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A modular genetic code expansion approach to site-specific lysine acylations 一个模块化的遗传密码扩展方法的位点特异性赖氨酸酰化

IF 23.5 1区化学

Chem Pub Date : 2026-03-03 DOI: 10.1016/j.chempr.2025.102919

Pascal Knecht, Tuan-Anh Nguyen, Kathrin Lang

{"title":"A modular genetic code expansion approach to site-specific lysine acylations","authors":"Pascal Knecht, Tuan-Anh Nguyen, Kathrin Lang","doi":"10.1016/j.chempr.2025.102919","DOIUrl":"https://doi.org/10.1016/j.chempr.2025.102919","url":null,"abstract":"Lysine acylations are a diverse class of posttranslational modifications (PTMs) that regulate protein function. Access to homogeneous, site-specifically modified proteins is essential for dissecting their molecular roles yet remains challenging with traditional methods. Here, we present a modular strategy combining genetic code expansion (GCE) with a chemoselective amide bond-forming reaction to install various lysine acylations directly onto folded proteins. The key to this approach is the genetic encoding of Nε-methoxylysine, which reacts efficiently with N-methyliminodiacetyl (MIDA) acylboronates to generate diverse acyl-lysine modifications from a single protein precursor, including several acyl PTMs not previously accessible through GCE. This mild and broadly applicable methodology enables systematic studies of lysine acylations on multiple target proteins. We demonstrate its utility by probing the effects of defined acyl modifications on enzymatic activity, protein-RNA interactions, and deacylase-mediated regulation. Altogether, this platform establishes a versatile strategy to interrogate the functional consequences of this widespread class of PTMs.","PeriodicalId":268,"journal":{"name":"Chem","volume":"107 1","pages":""},"PeriodicalIF":23.5,"publicationDate":"2026-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147360167","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

CO2 capture with post-modified nitrile and styrene-butadiene-styrene rubbers 后改性丁腈和苯乙烯-丁二烯-苯乙烯橡胶捕集二氧化碳

IF 23.5 1区化学

Chem Pub Date : 2026-02-27 DOI: 10.1016/j.chempr.2025.102918

Simon Stampe Kildahl, Clemens Kaussler, Ruth Ebenbauer, Thomas Balle Bech, Riccardo Giovanelli, Martin Lahn Henriksen, Mansurali Mithani, Ilke Uysal-Unalan, Dennis Wilkens Juhl, Niels Chr. Nielsen, Troels Skrydstrup

引用次数: 0

p-p orbital hybridization enables durable aqueous zinc-iodine batteries P-p轨道杂化使水锌-碘电池经久耐用

IF 23.5 1区化学

Chem Pub Date : 2026-02-26 DOI: 10.1016/j.chempr.2025.102911

Ying Wang, Yanqing Fu, Qiliang Wei, Dongjiang Yang, Qiao Liu, Weiyou Yang

{"title":"p-p orbital hybridization enables durable aqueous zinc-iodine batteries","authors":"Ying Wang, Yanqing Fu, Qiliang Wei, Dongjiang Yang, Qiao Liu, Weiyou Yang","doi":"10.1016/j.chempr.2025.102911","DOIUrl":"https://doi.org/10.1016/j.chempr.2025.102911","url":null,"abstract":"Aqueous zinc-iodine batteries (AZIBs) are attractive for safe and low-cost energy storage yet are hindered by sluggish iodine redox kinetics and severe polyiodide shuttling. While single-atom catalysts (SACs) based on d-block transition metals have been extensively explored, their limited orbital directionality constrains performance. Herein, we propose an orbital-engineering strategy using p-block elements to enable effective p-p orbital hybridization and enhanced electronic coupling. Bi SACs anchored on N-doped porous carbons (Bi-NC) leverage their semi-metallic nature to induce effective Bi 6p-I 5p interactions, thereby accelerating iodine conversion and suppressing shuttling. The Bi-NC/I2 cathode delivers 134.7 mAh g−1 with exceptional stability over 100,000 cycles at 16 A g−1, exhibiting only 0.000141% decay per cycle. Furthermore, a Zn/Bi-NC/I2 pouch cell achieves 1.07 mAh cm−2 and maintains 100% capacity retention after 200 cycles at 5 mA cm−2. This work establishes p-p orbital hybridization as a powerful design principle for durable aqueous batteries.","PeriodicalId":268,"journal":{"name":"Chem","volume":"25 1","pages":""},"PeriodicalIF":23.5,"publicationDate":"2026-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147319828","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A radical–polar crossover approach to complex nitrogen heterocycles via the triplet state 通过三重态研究复杂氮杂环的自由基-极性交叉方法

IF 23.5 1区化学

Chem Pub Date : 2026-02-18 DOI: 10.1016/j.chempr.2025.102904

Zachariah Lockhart, Mihai V. Popescu, Juan V. Alegre-Requena, Jay Ahuja, Shaokang Chai, Robert S. Paton, Martin D. Smith

{"title":"A radical–polar crossover approach to complex nitrogen heterocycles via the triplet state","authors":"Zachariah Lockhart, Mihai V. Popescu, Juan V. Alegre-Requena, Jay Ahuja, Shaokang Chai, Robert S. Paton, Martin D. Smith","doi":"10.1016/j.chempr.2025.102904","DOIUrl":"https://doi.org/10.1016/j.chempr.2025.102904","url":null,"abstract":"The transition from radical to ionic reactivity is a key design feature of many photochemical reactions, enabling complex transformations not possible under either mechanistic regime alone. Ground-state alkenes are common substrates in existing methods of this type, serving as radical acceptors to generate open-shell intermediates from which the radical–polar crossover (RPC) event is oxidatively or reductively triggered by a photocatalyst. Here, we describe an alternative RPC mechanism proceeding via an alkene triplet diradical. In this transformation, an iodine radical liberated during a homolytic aromatic substitution step functions as a single-electron oxidant to generate an iminium electrophile that can be intercepted en route to complex natural-product-like amines. An enantioselective variant of the reaction, enabled by an oxidatively installed sulfinyl leaving group, points to the generality of this underdeveloped pattern of diradical reactivity, paving the way for other triplet-state reactions that incorporate both one- and two-electron bond-forming processes.","PeriodicalId":268,"journal":{"name":"Chem","volume":"22 1","pages":""},"PeriodicalIF":23.5,"publicationDate":"2026-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146208792","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

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