Chem最新文献 - Book学术

Operando X-ray spectroscopies for tracking electrocatalytic dynamic interfaces across multiple scales 用于跨多个尺度跟踪电催化动态界面的Operando x射线光谱

IF 23.5 1区化学

Chem Pub Date : 2026-04-27 DOI: 10.1016/j.chempr.2026.103032

Kanglei Pang, Chang Long, Jiayin Yuan

引用次数: 0

Polymerase-mediated expansion of DNA nanostructures 聚合酶介导的DNA纳米结构扩增

IF 23.5 1区化学

Chem Pub Date : 2026-04-21 DOI: 10.1016/j.chempr.2026.103038

Hong Kang, Yuexuan Yang, Qishu Zhang, Qi Yan, Bryan Wei

引用次数: 0

Nanophase structuring in simple ternary solvents mediates reaction kinetics 简单三元溶剂中的纳米相结构介导反应动力学

IF 23.5 1区化学

Chem Pub Date : 2026-04-17 DOI: 10.1016/j.chempr.2026.103039

Yifei Wang, Binish Ashfaq, Jung-Bin Ahn, Peiran Wei, Lauren D. Zarzar

{"title":"Nanophase structuring in simple ternary solvents mediates reaction kinetics","authors":"Yifei Wang, Binish Ashfaq, Jung-Bin Ahn, Peiran Wei, Lauren D. Zarzar","doi":"10.1016/j.chempr.2026.103039","DOIUrl":"https://doi.org/10.1016/j.chempr.2026.103039","url":null,"abstract":"Solvents are crucial to chemical reactivity. Ternary mixtures of water, a water-miscible polar organic solvent, and a water-immiscible oil can self-organize into nanoscale domains (nanophases), yet their impact on reaction kinetics is not well understood. Here, we investigate how nanophase structuring affects strain-promoted azide-alkyne click (SPAAC) reaction kinetics. Ternary solvents were designed to promote or suppress nanophase structuring, characterized by dynamic light scattering (DLS) and small-angle X-ray scattering (SAXS). High-throughput ultraviolet-visible spectroscopy (UV-vis) kinetics revealed that hydrophobic reactants exhibited faster rates in ternary solvents compared with pure solvents and water-containing binary mixtures. Rate enhancements were confined to a narrow region of the phase diagram containing oil-in-water nanophases and disappeared when hydrophilic reactants were used or when nanophase stability was reduced. These findings demonstrate that simple ternary solvents modulate reaction kinetics in a manner distinct from bulk solvent polarity or conventional hydrophobic effects and highlight the potential of nanophases to control reactivity.","PeriodicalId":268,"journal":{"name":"Chem","volume":"224 1","pages":""},"PeriodicalIF":23.5,"publicationDate":"2026-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147709290","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Out-of-equilibrium confinement catalysis mediated by compressive force 压缩力介导的非平衡约束催化

IF 23.5 1区化学

Chem Pub Date : 2026-04-17 DOI: 10.1016/j.chempr.2026.103026

Fang-Zi Liu, Shi Li, Yufei Zhu, Yan Liu, Jian Wang, Heather J. Kulik, KaKing Yan

{"title":"Out-of-equilibrium confinement catalysis mediated by compressive force","authors":"Fang-Zi Liu, Shi Li, Yufei Zhu, Yan Liu, Jian Wang, Heather J. Kulik, KaKing Yan","doi":"10.1016/j.chempr.2026.103026","DOIUrl":"https://doi.org/10.1016/j.chempr.2026.103026","url":null,"abstract":"Biological systems sustain non-equilibrium states through continuous energy inputs such as light or chemical fuels, whereas synthetic systems typically dissipate energy toward equilibrium. Here, we demonstrate that mechanical force delivered via ball milling serves as a unique energy source to drive endergonic coordination self-assembly inaccessible through conventional stimuli. Mechanistic studies combining ball-milling kinetics, model reactions, and density functional theory (DFT) calculations reveal that direct mechanical impact strongly deforms coordination cages, elevating their ground-state energies. These distorted cages enable barrier-free guest release, followed by cage reassembly. By coupling this force-driven step with a subsequent equilibrium process, two unprecedented outcomes are achieved: (1) an out-of-equilibrium catalytic confinement cycle and (2) a dissipative cycle. Notably, this mechanochemical strategy circumvents product inhibition in equilibrium-based supramolecular systems, enabling transformations with up to 85 catalytic turnovers. Our work highlights mechanical force as a design principle for non-equilibrium chemistry toward life-like systems.","PeriodicalId":268,"journal":{"name":"Chem","volume":"19 1","pages":""},"PeriodicalIF":23.5,"publicationDate":"2026-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147709069","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Water-triggered photocatalytic oxidative coupling of methane toward C2H6 over Au/GaN nanoarchitecture 水触发的Au/GaN纳米结构上甲烷对C2H6的光催化氧化偶联

IF 23.5 1区化学

Chem Pub Date : 2026-04-17 DOI: 10.1016/j.chempr.2026.103033

Yixin Li, Lin Yao, Jinglin Li, Tianqi Yu, Andreas Kafizas, Ying Li, Liang Qiu, Lam Jun Kay, Tao Wang, Md Afjalur Rahman, Nirmal Anand, Sharif Md. Sadaf, Baowen Zhou

{"title":"Water-triggered photocatalytic oxidative coupling of methane toward C2H6 over Au/GaN nanoarchitecture","authors":"Yixin Li, Lin Yao, Jinglin Li, Tianqi Yu, Andreas Kafizas, Ying Li, Liang Qiu, Lam Jun Kay, Tao Wang, Md Afjalur Rahman, Nirmal Anand, Sharif Md. Sadaf, Baowen Zhou","doi":"10.1016/j.chempr.2026.103033","DOIUrl":"https://doi.org/10.1016/j.chempr.2026.103033","url":null,"abstract":"Solar-driven oxidative coupling of methane (CH4) offers a sustainable route for synthesizing value-added chemicals beyond petroleum. To address current thermodynamic and selectivity challenges, a photocatalytic system employing nano-gold-decorated GaN nanowires is developed for the efficient conversion of CH4 into ethane (C2H6), using water as a green oxidant. The optimized catalyst delivers a remarkable C2H6 production rate of 112.6 mmol⋅gcat−1⋅h−1 with 94.9% selectivity and a turnover number of 40,824 after 256 h operation. Mechanistic investigations reveal that photogenerated holes trapped at Au sites oxidize H2O into highly active ·OH radicals. These radicals significantly lower the energy barrier for C2H6 formation via an H-exchange mechanism. Ultimately, the synergistic Au/GaN interface inhibits CH4 over-oxidation, showcasing a highly promising, environmentally friendly pathway for solar-to-chemical energy conversion.","PeriodicalId":268,"journal":{"name":"Chem","volume":"15 1","pages":""},"PeriodicalIF":23.5,"publicationDate":"2026-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147709250","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Chasing nature’s anion binders 追逐大自然的阴离子粘合剂

IF 23.5 1区化学

Chem Pub Date : 2026-04-17 DOI: 10.1016/j.chempr.2026.103036

Junhong Li, Martin Stroet, Vivian G. Shang, Wenrui Lyu, Jack K. Clegg, Evelyne Deplazes, Xin Wu

引用次数: 0

Array of bimetallic metallophthalocyanine-based metal-organic frameworks for chemiresistive detection and differentiation of toxic gases 基于金属酞菁的双金属-有机框架阵列，用于有毒气体的化学抗性检测和鉴别

IF 23.5 1区化学

Chem Pub Date : 2026-04-17 DOI: 10.1016/j.chempr.2026.103037

Evan L. Cline, Hyuk-Jun Noh, Georganna Benedetto, Gbenga Fabusola, Aiden Hawkins, Cory M. Simon, Katherine A. Mirica

{"title":"Array of bimetallic metallophthalocyanine-based metal-organic frameworks for chemiresistive detection and differentiation of toxic gases","authors":"Evan L. Cline, Hyuk-Jun Noh, Georganna Benedetto, Gbenga Fabusola, Aiden Hawkins, Cory M. Simon, Katherine A. Mirica","doi":"10.1016/j.chempr.2026.103037","DOIUrl":"https://doi.org/10.1016/j.chempr.2026.103037","url":null,"abstract":"Rapid, low-power, room-temperature gas sensors are essential for human health and safety. Conductive metal-organic frameworks (cMOFs), particularly bimetallic two-dimensional layered MOFs based on metallophthalocyanine (MPc), have emerged as modular chemiresistive materials capable of room-temperature and low-power operation with rapid responses to gaseous analytes. This paper describes the use of nine structurally analogous MPc-based cMOFs for the detection of toxic gases. When combined with both unsupervised and supervised machine learning algorithms to interpret the response pattern, this array achieves discrimination between H2S, NO, and CO analytes in N2 at parts per million (ppm)-level concentrations. Spectroscopic studies and comparisons between the chemiresistive responses of the cMOFs revealed that their gaseous detection is dictated by the metal bis(dioxolene) moiety, which is involved in both gaseous analyte coordination and redox chemistry. This study opens the door to leveraging modular molecular design of reticular materials for strategic chemical detection in low-power, portable devices.","PeriodicalId":268,"journal":{"name":"Chem","volume":"22 1","pages":""},"PeriodicalIF":23.5,"publicationDate":"2026-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147726495","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The third wave of enzyme engineering: Navigating the AI-powered IDEA paradigm 酶工程的第三波浪潮：引导人工智能驱动的IDEA范式

IF 23.5 1区化学

Chem Pub Date : 2026-04-16 DOI: 10.1016/j.chempr.2026.103001

Shuaiqi Meng, Shiwei Cheng, Xiao Cheng, Dongzhi Wei, Xiujuan Li, Haiyang Cui

引用次数: 0

Single-molecule FRET enables the detection of site-specific α-synuclein serine phosphorylation 单分子FRET能够检测位点特异性α-突触核蛋白丝氨酸磷酸化

IF 23.5 1区化学

Chem Pub Date : 2026-04-16 DOI: 10.1016/j.chempr.2026.103030

Moon Hyeok Choi, Mike Filius, Senne Klomp, Yen Way Isabell Trinh, Adam Pomorski, Chirlmin Joo

{"title":"Single-molecule FRET enables the detection of site-specific α-synuclein serine phosphorylation","authors":"Moon Hyeok Choi, Mike Filius, Senne Klomp, Yen Way Isabell Trinh, Adam Pomorski, Chirlmin Joo","doi":"10.1016/j.chempr.2026.103030","DOIUrl":"https://doi.org/10.1016/j.chempr.2026.103030","url":null,"abstract":"Phosphorylation, a key posttranslational modification, plays a crucial role in regulating protein function and stability. However, conventional ensemble assays, such as ELISA, are unable to resolve phosphorylation at the proteoform level, thereby obscuring the heterogeneity of site-specific modifications. To address this limitation, we present a single-molecule analysis platform that combines site-specific labeling of phosphorylation sites with fluorescence resonance energy transfer (FRET) to pinpoint the location of phosphorylation sites in full-length proteins. We demonstrate the applicability of our approach on α-synuclein (αSyn), a protein implicated in neurodegenerative diseases. We can quantify the number of phosphorylation sites and identify which amino acids are phosphorylated on αSyn, depending on the type of kinase used. This single-molecule platform achieves picomolar (pM) sensitivity, enabling the detection of distinct phosphorylated proteoforms that are beyond the reach of conventional ensemble methods. Our approach enables detailed analysis of protein modifications in neurodegenerative diseases and may aid biomarker discovery.","PeriodicalId":268,"journal":{"name":"Chem","volume":"243 1","pages":""},"PeriodicalIF":23.5,"publicationDate":"2026-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147709280","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Expanding the territory to post-assembly modification of metallacages 将业务范围扩展到金属的装配后修改

IF 23.5 1区化学

Chem Pub Date : 2026-04-16 DOI: 10.1016/j.chempr.2026.103061

Sha Bai, Ying-Feng Han

引用次数: 0