Chem最新文献 - Book学术

Non-equilibrium autopoietic vesicles driven by intrinsic catalysis 由内在催化驱动的非平衡自创生囊泡

IF 23.5 1区化学

Chem Pub Date : 2025-06-23 DOI: 10.1016/j.chempr.2025.102630

Sangam Jha, Soumili Roy, Antara Reja, Ajeet Kumar Singh, Lisa Roy, Dibyendu Das

引用次数: 0

Precision comonomer sequence enables selective thermodynamic degradation of vinyl copolymers 精密共聚物序列使乙烯基共聚物的选择性热力学降解

IF 23.5 1区化学

Chem Pub Date : 2025-06-20 DOI: 10.1016/j.chempr.2025.102648

Francesca D. Eckstrom, Eugene Y.-X. Chen

引用次数: 0

Triazasupersumanenes: Bowl-shaped nanographenes with tunable properties and unexpected charge transport performance 碗状纳米石墨烯，具有可调性质和意想不到的电荷传输性能

IF 23.5 1区化学

Chem Pub Date : 2025-06-20 DOI: 10.1016/j.chempr.2025.102628

Bo Yang, Yixun Sun, Jiale Hu, Si Meng, Muhua Chen, Xin Wang, Min Ren, Jing Guo, Yiting Wang, Ji Li, Min Jia, Juan Fan, Huaming Sun, Jing Li, Hua Xu, Junfa Wei

{"title":"Triazasupersumanenes: Bowl-shaped nanographenes with tunable properties and unexpected charge transport performance","authors":"Bo Yang, Yixun Sun, Jiale Hu, Si Meng, Muhua Chen, Xin Wang, Min Ren, Jing Guo, Yiting Wang, Ji Li, Min Jia, Juan Fan, Huaming Sun, Jing Li, Hua Xu, Junfa Wei","doi":"10.1016/j.chempr.2025.102628","DOIUrl":"https://doi.org/10.1016/j.chempr.2025.102628","url":null,"abstract":"Doping heteroatoms into the π-skeleton of buckybowls is a promising strategy for modulating molecular geometry and electronic structures, thereby imparting unique physicochemical properties. In this study, we present the synthesis and characterization of three bowl-shaped nitrogen-doped nanographenes, known as triazasupersumanenes, which feature a coronene core surrounded by alternating five- and six-membered rings. These typical π-bowls display deeper bowl depths, remarkable redshifts in both absorption and emission spectra, and more reversible oxidation peaks compared with their S-doped analog. Furthermore, <em>para</em>-substituents on N-aryls significantly influence molecular properties and exhibit intriguing characteristics, including polar crystals, reversible mechanofluorochromic (MFC) performance, open-shell diradical dication, and supramolecular recognition for fullerene C<sub>60</sub>. Despite no π⋯π interactions, the fabricated device <strong>1a@CHCl</strong><sub><strong>3</strong></sub> exhibits unexpected <em>p</em>-type transport properties in organic field-effect transistor measurements. This work reveals the structure-property relationships of heterosupersumanenes, offering valuable insights into the design and synthesis of π-bowls with tunable properties and highlighting their potential as organic semiconductors.","PeriodicalId":268,"journal":{"name":"Chem","volume":"179 1","pages":""},"PeriodicalIF":23.5,"publicationDate":"2025-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144329262","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Protein-based nanomedicines for cancer theranostics: From supramolecular self-assembly to AI-driven design and applications 基于蛋白质的癌症治疗纳米药物：从超分子自组装到人工智能驱动的设计和应用

IF 23.5 1区化学

Chem Pub Date : 2025-06-19 DOI: 10.1016/j.chempr.2025.102624

Hong-Bo Cheng, Yang Cheng, Junlan Wang, Hancong Liu, Keyue Zhang, Ruotong Wu, Jiaxin Li, Yanyan Fang, Runjing Hu, Hyunsun Jeong, Paul J. Dyson, Xing-Jie Liang, Juyoung Yoon

{"title":"Protein-based nanomedicines for cancer theranostics: From supramolecular self-assembly to AI-driven design and applications","authors":"Hong-Bo Cheng, Yang Cheng, Junlan Wang, Hancong Liu, Keyue Zhang, Ruotong Wu, Jiaxin Li, Yanyan Fang, Runjing Hu, Hyunsun Jeong, Paul J. Dyson, Xing-Jie Liang, Juyoung Yoon","doi":"10.1016/j.chempr.2025.102624","DOIUrl":"https://doi.org/10.1016/j.chempr.2025.102624","url":null,"abstract":"Protein-based nanomedicines represent a paradigm shift in cancer theranostics, capitalizing on superior biocompatibility, molecular recognition, and multifunctional adaptability. This review delineates their evolution from supramolecular self-assembly to artificial intelligence (AI)-driven design, emphasizing their transformative role in cancer chemotherapy, phototherapy, chemodynamic therapy, and immunotherapy. Supramolecular strategies, including metal coordination, electrostatic interactions, host-guest chemistry, hydrogen bonding, <em>π</em>-<em>π</em> stacking, and hydrophobic interactions, not only enable precise control over protein assemblies but also facilitate drug delivery and performance. AI tools like AlphaFold 3 and RFdiffusion have accelerated <em>de novo</em> protein design and dynamic interaction prediction, overcoming limitations in structural prototyping. Despite breakthroughs, challenges persist in the mechanistic insights into assembly dynamics, experimental validation of AI-generated constructs, and scalable clinical translation. Future directions prioritize integrated theranostics platforms, multi-omics-guided precision medicine, and synthetic biology. By synergizing supramolecular chemistry, AI, and nanotechnology, this review envisions protein-based nanomedicines as intelligent, adaptive systems poised to redefine paradigms of cancer theranostics.","PeriodicalId":268,"journal":{"name":"Chem","volume":"183 1","pages":""},"PeriodicalIF":23.5,"publicationDate":"2025-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144319645","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Catalytic and selective chemical recycling of post-consumer rubbers into cycloalkenes 消费后橡胶催化和选择性化学回收制备环烯烃

IF 23.5 1区化学

Chem Pub Date : 2025-06-18 DOI: 10.1016/j.chempr.2025.102625

Beomsoon Park, Kyoungil Cho, Kyungmin Choi, Soon Hyeok Hong

引用次数: 0

Enhanced X-ray luminescence in one-dimensional Cu–I coordination polymers via ligand halogen engineering 通过配体卤素工程增强一维Cu-I配位聚合物的x射线发光

IF 19.1 1区化学

Chem Pub Date : 2025-06-12 DOI: 10.1016/j.chempr.2024.102401

Wentao Wu (吴文涛) , Shuyi Lin , Jian-Xin Wang , Yafeng Xu , Tengyue He , Yang Zhou , Peng Yuan , Partha Maity , Issatay Nadinov , Simil Thomas , Renwu Huang , Catherine S.P. De Castro , Jun Yin , Husam N. Alshareef , Osman M. Bakr , Omar F. Mohammed

{"title":"Enhanced X-ray luminescence in one-dimensional Cu–I coordination polymers via ligand halogen engineering","authors":"Wentao Wu (吴文涛) , Shuyi Lin , Jian-Xin Wang , Yafeng Xu , Tengyue He , Yang Zhou , Peng Yuan , Partha Maity , Issatay Nadinov , Simil Thomas , Renwu Huang , Catherine S.P. De Castro , Jun Yin , Husam N. Alshareef , Osman M. Bakr , Omar F. Mohammed","doi":"10.1016/j.chempr.2024.102401","DOIUrl":"10.1016/j.chempr.2024.102401","url":null,"abstract":"<div><div>Cu(I) halide-based scintillators are emerging as eco-friendly alternatives to traditional X-ray imaging scintillators because of their high luminescence efficiency and solution processability. Although much progress has been made in zero-dimensional (0D) Cu–I cluster scintillators, there has been limited focus on one-dimensional (1D) Cu–I coordination polymers because of their lower luminescence efficiencies. This study presents a ligand halogen engineering strategy for significantly enhancing the photoluminescence efficiency of 1D Cu–I coordination polymers by utilizing halogen-based chemical modifications. The chlorine-modified ligands increase structural rigidity, reducing electronic repulsion between copper and iodine atoms and minimizing photon loss through non-radiative recombination pathways, resulting in an impressive photoluminescence quantum yield of nearly 100%. The designed scintillators demonstrate improved radioluminescence intensity, low detection limits, and exceptional spatial resolution (16 lp/mm). This research offers an approach for creating highly emissive 1D Cu–I coordination polymers and highlights their potential in X-ray imaging applications in medical diagnosis and security checks.</div></div>","PeriodicalId":268,"journal":{"name":"Chem","volume":"11 6","pages":"Article 102401"},"PeriodicalIF":19.1,"publicationDate":"2025-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143124916","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Homeostatic artificial cells enable self-protection in prototissue spheroids 稳态人工细胞在原组织球体中实现自我保护

IF 19.1 1区化学

Chem Pub Date : 2025-06-12 DOI: 10.1016/j.chempr.2024.102409

Joshua Krehan , Chuen-Ru Li , Marcos Masukawa , Esther Amstad , Andreas Walther

{"title":"Homeostatic artificial cells enable self-protection in prototissue spheroids","authors":"Joshua Krehan , Chuen-Ru Li , Marcos Masukawa , Esther Amstad , Andreas Walther","doi":"10.1016/j.chempr.2024.102409","DOIUrl":"10.1016/j.chempr.2024.102409","url":null,"abstract":"<div><div>Prototissues made from artificial cells (ACs) aim to replicate the behaviors of living tissues, such as communication, collective behavior, and homeostasis. Despite progress in developing diverse AC types, building prototissues and achieving effective communication as well as collective behavior in such prototissues remain challenging. We introduce ACs with an intrinsic homeostatic pH control mechanism that can be organized into prototissues to collectively maintain a stable microenvironment and protect cargo from environmental pH fluctuations. These ACs contain pH-modulating enzymes within a pH-sensitive membrane, allowing for self-regulation through chemo-structural feedback. They adjust pH by importing substrates within a specific pH range and self-regulate to control substrate influx. This enables them to modulate local pH, manage cargo release, and facilitate interactive communication in organized spheroids. Our findings demonstrate the potential of homeostatic ACs to create advanced synthetic tissue mimics, replicating protective and communicative functions of living tissues for biomedical and tissue engineering applications.</div></div>","PeriodicalId":268,"journal":{"name":"Chem","volume":"11 6","pages":"Article 102409"},"PeriodicalIF":19.1,"publicationDate":"2025-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143258282","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Polar π stacking for metal-free near, remote, and ultra-remote C–H coupling with aryliodanes 极性π堆叠与芳基二极管的无金属近程、远程和超远程 C-H 耦合

IF 19.1 1区化学

Chem Pub Date : 2025-06-12 DOI: 10.1016/j.chempr.2025.102546

Jorge D. Martín-Bernardos , Katrin Golob , Wei W. Chen , Orsola A. Luongo , Inés Sedó , Ana B. Cuenca , Alexandr Shafir

{"title":"Polar π stacking for metal-free near, remote, and ultra-remote C–H coupling with aryliodanes","authors":"Jorge D. Martín-Bernardos , Katrin Golob , Wei W. Chen , Orsola A. Luongo , Inés Sedó , Ana B. Cuenca , Alexandr Shafir","doi":"10.1016/j.chempr.2025.102546","DOIUrl":"10.1016/j.chempr.2025.102546","url":null,"abstract":"<div><div>We introduce a C–H coupling process in which an aromatic C–I position serves as trampoline for targeting various aromatic C–H positions. The reaction is set in motion by an interaction between the λ<sup>3</sup>-iodane ArI(OAc)<sub>2</sub> and the π system of polyunsaturated organosilanes. In particular, the silyl-terminated enynes engage in fully regioselective <em>ortho</em> and <em>para</em> C–H functionalization, with selectivity switch achieved by reversing the order of the substrate’s ene and yne fragments. Density functional theory (DFT) calculations show that the <em>ortho</em> selectivity is governed by a [3,3] sigmatropic rearrangement, while the <em>para</em> coupling occurs through a directional three-point π interaction of the enyne-derived cationic π system, giving rise to an essentially barrierless [5,5] sigmatropic rearrangement. Furthermore, iodane-guided C–H functionalization of 2-iodonaphthalene could be directed to the ultra-remote C6 position through further π extension of the organosilanes partner. The latter reaction represents a nearly unprecedented example of a formal [7,7] sigmatropic rearrangement.</div></div>","PeriodicalId":268,"journal":{"name":"Chem","volume":"11 6","pages":"Article 102546"},"PeriodicalIF":19.1,"publicationDate":"2025-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143846495","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Directed discovery of high-loading nanoaggregates enabled by drug-matched oligo-peptide excipients 定向发现高负载纳米聚集体的药物匹配寡肽辅料

IF 19.1 1区化学

Chem Pub Date : 2025-06-12 DOI: 10.1016/j.chempr.2024.102404

Naxhije Berisha , Atena Farahpour , Maithreyi Ramakrishnan , Chen Chen , Scott A. McPhee , Tong Wang , Tai-De Li , Kuntrapakam Hema , Magdalini Panagiotakopoulou , Vignesh Athiyarath , Maeva Coste , Yaron Marciano , Emmet Sherman , Rein V. Ulijn , Daniel A. Heller

{"title":"Directed discovery of high-loading nanoaggregates enabled by drug-matched oligo-peptide excipients","authors":"Naxhije Berisha , Atena Farahpour , Maithreyi Ramakrishnan , Chen Chen , Scott A. McPhee , Tong Wang , Tai-De Li , Kuntrapakam Hema , Magdalini Panagiotakopoulou , Vignesh Athiyarath , Maeva Coste , Yaron Marciano , Emmet Sherman , Rein V. Ulijn , Daniel A. Heller","doi":"10.1016/j.chempr.2024.102404","DOIUrl":"10.1016/j.chempr.2024.102404","url":null,"abstract":"<div><div>Nanoparticles can improve drug pharmacokinetics, but low loading efficiencies can limit treatment efficacy. Drug-aggregation-based nanoparticles have demonstrated improved loadings of up to 90%, but few excipients facilitate efficient co-assembly. We investigated peptides as designer excipients because of their diverse chemical space and inherent biodegradability. We designed pentapeptide scaffolds to mimic the structure of known indocyanine excipients by modulating aromaticity, rigidity, and charge. We screened 184 formulations by using diverse drug cargoes. We found drug-peptide combinations that formed nanoparticles with up to 98% drug loading. Molecular dynamics simulations and mass spectrometry analysis demonstrated that tryptophan-drug interactions and solvent exposure of charged amino acid residues drove the formation of core-shell structures. Peptide-drug formulations containing the JAK2/FLT3 inhibitor lestaurtinib were investigated in acute myeloid leukemia models, resulting in enhanced anti-tumor efficacy. This work found that oligopeptides can be designed to efficiently co-assemble with therapeutic cargoes to result in high-loading nanoparticles that improve anti-tumor efficacy.</div></div>","PeriodicalId":268,"journal":{"name":"Chem","volume":"11 6","pages":"Article 102404"},"PeriodicalIF":19.1,"publicationDate":"2025-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143027096","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Coordination-templated construction of single-crystal covalent organic frameworks 单晶共价有机骨架的配位模板构建

IF 19.1 1区化学

Chem Pub Date : 2025-06-12 DOI: 10.1016/j.chempr.2024.102398

Wenqiang Zhang , Yuting Zhang , Weili Ma , Xing Han , Wei Gong , Yan Liu , Yong Cui

{"title":"Coordination-templated construction of single-crystal covalent organic frameworks","authors":"Wenqiang Zhang , Yuting Zhang , Weili Ma , Xing Han , Wei Gong , Yan Liu , Yong Cui","doi":"10.1016/j.chempr.2024.102398","DOIUrl":"10.1016/j.chempr.2024.102398","url":null,"abstract":"<div><div>Covalent organic frameworks (COFs) and metal-organic frameworks (MOFs) are sought for their tunable porous structures and potential utility. Whereas the coordination bonds in MOFs enable the generation of single crystals, facilitating insight into structure-function relationships, this is not typically the case for COFs. Here, we present a simple and rapid synthetic method that exploits coordination-directed imine formation to prepare families of highly crystalline porous materials that are MOF-COF (MOCOF) hybrids. This synthetic approach consistently provides 14 high-quality single crystals formed using various combinations of imine (COF) and N-donor linker ligand (MOF) within 1 to 2 days, with sizes ranging from 50 to 500 μm, allowing determination of the single-crystal X-ray structures. These crystal structures provide insight into architectures, structural evolution, and host-guest interactions (including chirality recognition) with atomic resolution. Moreover, these MOCOF hybrids can be deconstructed through linker ligand removal and exfoliated to form ultrathin COF nanosheets.</div></div>","PeriodicalId":268,"journal":{"name":"Chem","volume":"11 6","pages":"Article 102398"},"PeriodicalIF":19.1,"publicationDate":"2025-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143192478","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0