Chem最新文献 - Book学术

Redefining forever: Advancements, challenges, and opportunities in covalent organic frameworks for the remediation of forever chemicals 重新定义永远：进步，挑战和机遇在共价有机框架的永久化学品的补救

IF 23.5 1区化学

Chem Pub Date : 2025-10-08 DOI: 10.1016/j.chempr.2025.102758

Asmaa Jrad, Bikash Garai, Samer Aouad, Gobinda Das, Connor M. Duncan, Mark A. Olson, Ali Trabolsi

{"title":"Redefining forever: Advancements, challenges, and opportunities in covalent organic frameworks for the remediation of forever chemicals","authors":"Asmaa Jrad, Bikash Garai, Samer Aouad, Gobinda Das, Connor M. Duncan, Mark A. Olson, Ali Trabolsi","doi":"10.1016/j.chempr.2025.102758","DOIUrl":"https://doi.org/10.1016/j.chempr.2025.102758","url":null,"abstract":"Per- and polyfluoroalkyl substances (PFAS), known as “forever chemicals,” are persistent pollutants with serious environmental and health impacts. Conventional water treatment methods often fall short of removing PFAS, prompting interest in advanced adsorbents such as covalent organic frameworks (COFs). This review explores recent advances in the development of COFs tailored for PFAS removal. The discussion focuses on key adsorption mechanisms, including hydrophobic, fluorophilic, electrostatic, and hydrogen-bonding interactions. In addition, optimizing pore size and particle size to improve the adsorption of PFAS is highlighted. The potential of COFs for practical applications is evaluated through their integration into composites, membranes, and adsorption columns, which enable continuous flow treatment. Despite promising results, challenges remain, including scalability, synthesis complexity, and realistic testing at environmentally relevant PFAS concentrations. The outline of future research directions aims to drive the advancement of COF-based solutions that have the potential to revolutionize PFAS remediation in real-world applications.","PeriodicalId":268,"journal":{"name":"Chem","volume":"349 1","pages":""},"PeriodicalIF":23.5,"publicationDate":"2025-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145241672","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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The AMI-isonitrile ligation 2.0: Fast, selective, and pH sensitive ami -异腈连接2.0：快速，选择性和pH敏感

IF 23.5 1区化学

Chem Pub Date : 2025-10-08 DOI: 10.1016/j.chempr.2025.102752

Maurice P. Biedermann, Athanasios Markos, Ian Warm, Adeline Schmitt, Johannes Heimgärtner, Kathrin Lang, Helma Wennemers

引用次数: 0

Nickel-embedded covalent organic frameworks for dual photocatalytic hydrogen evolution and cross-coupling catalysis 镍包埋共价有机框架双光催化析氢和交叉偶联催化

IF 23.5 1区化学

Chem Pub Date : 2025-10-07 DOI: 10.1016/j.chempr.2025.102751

Swati Jindal, Kuntal Pal, Mostafa Zeama, Partha Maity, Tian Jin, Mickaele Bonneau, Rajesh Kancherla, Omar F. Mohammed, Osama Shekhah, Magnus Rueping, Mohamed Eddaoudi

{"title":"Nickel-embedded covalent organic frameworks for dual photocatalytic hydrogen evolution and cross-coupling catalysis","authors":"Swati Jindal, Kuntal Pal, Mostafa Zeama, Partha Maity, Tian Jin, Mickaele Bonneau, Rajesh Kancherla, Omar F. Mohammed, Osama Shekhah, Magnus Rueping, Mohamed Eddaoudi","doi":"10.1016/j.chempr.2025.102751","DOIUrl":"https://doi.org/10.1016/j.chempr.2025.102751","url":null,"abstract":"This work reports the design and synthesis of a novel imine-linked 2D covalent organic framework (COF), TPDA-BiPy-COF, constructed from [3,3′-bipyridine]-6,6′-dicarboxaldehyde (3,3′-BiPy) as an electron acceptor and tetrakis(4-aminophenyl)-1,4-phenylenediamine (TPDA) as a donor. The COF features pyridyl-imine linkages, i.e., Nimine-Ni-Nbipyridine, with active nitrogen sites that facilitate proton reduction to hydrogen. To improve photocatalytic hydrogen evolution performance, Ni(II) centers were introduced via post-synthetic metalation, forming TPDA-BiPy@NiX₂ COF (X = Cl, Br). The coordination of Ni(II) with the imine and bipyridine nitrogen atoms enhanced framework planarity and conjugation, thereby boosting photocatalytic activity. Notably, TPDA-BiPy@Ni(II) COF achieved an excellent hydrogen evolution rate of 34.13 mmol g⁻¹ h⁻¹ under visible light, without requiring a cocatalyst. Furthermore, the metallaphotoredox activity of TPDA-BiPy@Ni(II) displayed its promise for photocatalyzed C–S cross-coupling reaction. This dual-functional catalyst highlights the advantage of incorporating nickel into COFs, offering a cost-effective and sustainable alternative to noble-metal-based systems for photocatalysis and synthetic transformations.","PeriodicalId":268,"journal":{"name":"Chem","volume":"84 1","pages":""},"PeriodicalIF":23.5,"publicationDate":"2025-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145241673","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Spatially resolved reaction environments in mechanochemical upcycling of polymers 聚合物机械化学升级循环中的空间分解反应环境

IF 23.5 1区化学

Chem Pub Date : 2025-10-06 DOI: 10.1016/j.chempr.2025.102754

Kinga Gołąbek, Yuchen Chang, Lauren R. Mellinger, Mariana V. Rodrigues, Cauê de Souza Coutinho Nogueira, Fabio B. Passos, Yutao Xing, Aline Ribeiro Passos, Mohammed H. Saffarini, Austin B. Isner, David S. Sholl, Carsten Sievers

引用次数: 0

Photolysis-generated sulfenylnitrenes enable site-selective nitrogen-atom insertion into N-heterocycles 光解作用产生的亚砜基亚硝基烯能够选择性地将氮原子插入到n杂环中

IF 23.5 1区化学

Chem Pub Date : 2025-10-03 DOI: 10.1016/j.chempr.2025.102753

Prakash Kafle, Prabhat Kharel, Daniel Nilson, Deacon Herndon, Shuhei Yasuda, Indrajeet Sharma

{"title":"Photolysis-generated sulfenylnitrenes enable site-selective nitrogen-atom insertion into N-heterocycles","authors":"Prakash Kafle, Prabhat Kharel, Daniel Nilson, Deacon Herndon, Shuhei Yasuda, Indrajeet Sharma","doi":"10.1016/j.chempr.2025.102753","DOIUrl":"https://doi.org/10.1016/j.chempr.2025.102753","url":null,"abstract":"This research delineates a photochemical methodology for generating sulfenylnitrenes from bench-stable precursors via blue-light irradiation without photosensitizers or additives. The resultant sulfenylnitrenes facilitate chemo- and site-selective incorporation of nitrogen atoms into N-heterocycles under mild, aqueous conditions. This approach transforms readily accessible pyrroles, indoles, and imidazoles into synthetically challenging pyrimidines, quinazolines, and triazines with high regioselectivity. Mechanistic investigations and density functional theory calculations provide insight into the origins of the observed regioselectivity. The reaction is compatible with a variety of oxidation-sensitive functional groups. It applies to the late-stage functionalization of bioactive molecules, including natural products, amino acids, C-glycosides, N-nucleosides, and pharmaceuticals. The operational simplicity, functional group tolerance, and extensive substrate scope emphasize the utility of this methodology and augment the repertoire of blue-light-mediated transformations, thereby contributing to the exploration of new chemical space for applications in medicinal chemistry and drug discovery.","PeriodicalId":268,"journal":{"name":"Chem","volume":"17 1","pages":""},"PeriodicalIF":23.5,"publicationDate":"2025-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145209870","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Structure-performance relationships for catalysis-driven molecular machinery 催化驱动分子机械的结构-性能关系

IF 23.5 1区化学

Chem Pub Date : 2025-10-03 DOI: 10.1016/j.chempr.2025.102742

Joaquin Baixeras Buye, James M. Gallagher, David A. Leigh

{"title":"Structure-performance relationships for catalysis-driven molecular machinery","authors":"Joaquin Baixeras Buye, James M. Gallagher, David A. Leigh","doi":"10.1016/j.chempr.2025.102742","DOIUrl":"https://doi.org/10.1016/j.chempr.2025.102742","url":null,"abstract":"Chemically fueled molecular motors are key to life’s most fundamental processes. In recent years, theoretical and experimental insights garnered from chemistry, biology, and physics have led to an understanding of the molecular basis of catalysis-driven motor mechanisms. Unlike their biological counterparts, for which evolutionary baggage and complexity often preclude a complete untangling of the reasons behind particular aspects of their mechanisms, artificial small-molecule motors operate with mechanisms that are entirely knowable. Here, we outline how key performance indicators, such as speed, stalling force, and fuel efficiency, are related to distinct structural and mechanistic features, contextualizing the analysis with both biological and small-molecule examples. These provide rational design principles for functional chemically fueled molecular machinery and benchmarking comparisons with biomolecular machinery. We have made available as a Jupyter notebook an interactive visualization tool that highlights how the key performance indicators change and depend upon the underlying kinetics of chemical fueling: https://github.com/JoaquinBaixerasBuye/Performance-Characteristics-of-Motors<svg aria-label=\"Opens in new window\" focusable=\"false\" height=\"20\" viewbox=\"0 0 8 8\"><path d=\"M1.12949 2.1072V1H7V6.85795H5.89111V2.90281L0.784057 8L0 7.21635L5.11902 2.1072H1.12949Z\"></path></svg>.","PeriodicalId":268,"journal":{"name":"Chem","volume":"99 1","pages":""},"PeriodicalIF":23.5,"publicationDate":"2025-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145209869","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Modular train-style nanorobots for targeted deep penetration and multi-directional collaborative treatment of colorectal cancer 用于大肠癌靶向深度穿透和多方向协同治疗的模块化列车式纳米机器人

IF 23.5 1区化学

Chem Pub Date : 2025-10-01 DOI: 10.1016/j.chempr.2025.102750

Jiamin Ye, Yueyue Fan, Gaoli Niu, Yong Kang, Jiacheng Shi, Ruiyan Li, Yiwen Yang, Xiaoyuan Ji

{"title":"Modular train-style nanorobots for targeted deep penetration and multi-directional collaborative treatment of colorectal cancer","authors":"Jiamin Ye, Yueyue Fan, Gaoli Niu, Yong Kang, Jiacheng Shi, Ruiyan Li, Yiwen Yang, Xiaoyuan Ji","doi":"10.1016/j.chempr.2025.102750","DOIUrl":"https://doi.org/10.1016/j.chempr.2025.102750","url":null,"abstract":"Colorectal cancer (CRC) remains a major global health challenge due to insufficient tumor penetration and immunosuppressive microenvironments. Herein, we propose a modular train-style nanorobot (TPP-Exo@LOX-Pd-Cu7S4) as a targeted synergistic therapeutic platform for CRC. The exosome “head” enables neutrophil-like tumor homing, while the Cu7S4 “tail” generates thermophoretic propulsion for deep tumor penetration. Under near-infrared region II (NIR-II) laser irradiation, the Pd-Cu7S4 Schottky heterojunction drives highly efficient catalytic cascades, disrupting redox homeostasis and inducing metabolic stress by converting O₂ to ·O₂−, H₂O₂ to ·OH, GSH to GSSG, NADH to NAD+, and lactate to pyruvate. The nanorobot directly targets mitochondria to reprogram tumor metabolism and trigger cuproptosis. Meanwhile, lactate oxidase (LOX), encapsulated within the engineered exosomes, depletes excess lactate to relieve immunosuppression and boost antitumor immunity. In CRC models, these nanorobots exhibit strong barrier penetration, precise targeting, and deep tumor infiltration, offering a multifunctional and metabolically disruptive therapeutic approach.","PeriodicalId":268,"journal":{"name":"Chem","volume":"2 1","pages":""},"PeriodicalIF":23.5,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145194962","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Lighting up dark reactions: An imine network ratchets a coupled equilibrium 点亮暗反应：亚胺网络棘轮耦合平衡

IF 23.5 1区化学

Chem Pub Date : 2025-09-26 DOI: 10.1016/j.chempr.2025.102783

Merve Temel, Stefano Crespi

引用次数: 0

Zeolite-stabilized trinuclear Zn1Cu2 sites catalyze CO2 hydrogenation to methanol 沸石稳定的三核Zn1Cu2位点催化CO2加氢制甲醇

IF 23.5 1区化学

Chem Pub Date : 2025-09-26 DOI: 10.1016/j.chempr.2025.102743

Jiahan Zhao, Bin Qin, Zhenghan Zhang, Siqi Zhu, Guangjun Wu, Jian Li, Yuchao Chai, Landong Li

{"title":"Zeolite-stabilized trinuclear Zn1Cu2 sites catalyze CO2 hydrogenation to methanol","authors":"Jiahan Zhao, Bin Qin, Zhenghan Zhang, Siqi Zhu, Guangjun Wu, Jian Li, Yuchao Chai, Landong Li","doi":"10.1016/j.chempr.2025.102743","DOIUrl":"https://doi.org/10.1016/j.chempr.2025.102743","url":null,"abstract":"CuZn-based catalysts like Cu/ZnO/Al2O3 have been extensively investigated for CO2 hydrogenation to methanol, while the active sites and underlying mechanism are hotly debated due to the ultra-high CuZn loadings and the structural complexity thereof. We report herein that zeolite-stabilized trinuclear Zn1Cu2 sites can efficiently catalyze the selective hydrogenation of CO2 to methanol, surpassing the performance of the benchmark CuZn-based catalyst, although the CuZn loading is over an order of magnitude lower. Both experimental evidence and theoretical calculations reveal the formate pathway of CO2 hydrogenation with the involvement of the Cu2+-Cuδ+-Cu2+ redox cycle. Zn ions incorporated into the zeolite framework play an essential role in stabilizing cationic Cu species against overreduction to less active metallic Cu during the reaction. Our results provide new insights into the chemistry of CO2 stepwise hydrogenation to methanol, which are useful for the rational design of catalysts.","PeriodicalId":268,"journal":{"name":"Chem","volume":"18 1","pages":""},"PeriodicalIF":23.5,"publicationDate":"2025-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145141112","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Rewriting lysine reactivity: Lysine-targeted bioconjugation via biomimetic polarity reversal for diversified biomolecule modification 改写赖氨酸反应性：赖氨酸靶向生物偶联，通过仿生极性反转实现多种生物分子修饰

IF 23.5 1区化学

Chem Pub Date : 2025-09-25 DOI: 10.1016/j.chempr.2025.102744

Lu Wang, Hongxiang Yang, Jianwen Cui, Xiaoping Chen, Biao Yu, Xiaheng Zhang

引用次数: 0