Chem最新文献_第9页

An aqueous artificial molecular pump 一种水人工分子泵

IF 23.5 1区化学

Chem Pub Date : 2025-08-05 DOI: 10.1016/j.chempr.2025.102693

Christopher K. Lee, Yuanning Feng, Alan E. Enciso, Jake P. Violi, William A. Donald, J. Fraser Stoddart, Dong Jun Kim

引用次数: 0

A catalytic approach to the valorization of polyesters and biogenic waste for the production of amines 聚酯和生物废物催化增值生产胺的方法

IF 23.5 1区化学

Chem Pub Date : 2025-07-30 DOI: 10.1016/j.chempr.2025.102667

Fairoosa Poovan, Rajenahally V. Jagadeesh, Matthias Beller

引用次数: 0

Fast reverse intersystem crossing over 107 s−1 via near-enantiomeric charge-transfer transitions 通过近对映体电荷转移跃迁，在107 s−1内快速反向系统间交叉

IF 23.5 1区化学

Chem Pub Date : 2025-07-29 DOI: 10.1016/j.chempr.2025.102685

Hai Zhang, Tianyu Huang, Jianping Zhou, Chunlin Xu, Dongdong Zhang, Lian Duan

{"title":"Fast reverse intersystem crossing over 107 s−1 via near-enantiomeric charge-transfer transitions","authors":"Hai Zhang, Tianyu Huang, Jianping Zhou, Chunlin Xu, Dongdong Zhang, Lian Duan","doi":"10.1016/j.chempr.2025.102685","DOIUrl":"https://doi.org/10.1016/j.chempr.2025.102685","url":null,"abstract":"Thermally activated delayed fluorescence (TADF) enables high-efficiency organic light-emitting diodes (OLEDs) through reverse intersystem crossing (RISC) of triplet excitons, yet existing systems struggle to achieve fast RISC rates (kRISC >107 s−1), let alone balance a high radiative decay (kr). Herein, we develop a dual-donor TADF emitter that bypasses the El-Sayed rule restriction by harnessing near-enantiomeric charge-transfer transitions between a high-lying triplet state and the lowest singlet state and that synergizes with heavy atoms to enhance spin-orbit coupling. This design yields a kRISC of 1.54 × 107 s−1 alongside a kr of 9.65 × 106 s−1, reducing the delayed fluorescence lifetime to 1.46 μs. The OLED exhibits a peak external quantum efficiency of 30.6% with minimal roll-off (30.4% at 5,000 cd m−2) and an operational lifetime exceeding 1,500 h at 1,000 cd m−2 before the luminance decays to 95% of its initial value, which extends further to 3,876 h via sensitized narrowband emission. This work bypasses conventional localized triplet-intermediate-dependent RISC mechanisms and establishes a paradigm for designing high-efficiency, stable TADF materials.","PeriodicalId":268,"journal":{"name":"Chem","volume":"24 1","pages":""},"PeriodicalIF":23.5,"publicationDate":"2025-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144720227","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Schwarzite—The holy grail of carbon allotropes 史瓦锆石——碳同素异形体的圣杯

IF 23.5 1区化学

Chem Pub Date : 2025-07-28 DOI: 10.1016/j.chempr.2025.102658

Jonas Spengler, Yvonne Wagenhäuser, Frank Würthner

引用次数: 0

Strategic scaffold redesign of ecteinascidins: An approach for generating anticancer macrocycles 外皮酸苷的战略性支架重新设计：一种产生抗癌大周期的方法

IF 23.5 1区化学

Chem Pub Date : 2025-07-18 DOI: 10.1016/j.chempr.2025.102664

Ryo Tanifuji, Erina Hosono, Hisae Kamakura, Yukiko Muramatsu, Satoshi Yoshida, Sota Sato, Yoshimi Ohashi, Shingo Dan, Hiroyuki Seimiya, Hiroki Oguri

{"title":"Strategic scaffold redesign of ecteinascidins: An approach for generating anticancer macrocycles","authors":"Ryo Tanifuji, Erina Hosono, Hisae Kamakura, Yukiko Muramatsu, Satoshi Yoshida, Sota Sato, Yoshimi Ohashi, Shingo Dan, Hiroyuki Seimiya, Hiroki Oguri","doi":"10.1016/j.chempr.2025.102664","DOIUrl":"https://doi.org/10.1016/j.chempr.2025.102664","url":null,"abstract":"Strategies for rational design and scaffold diversification of therapeutically valuable yet synthetically challenging natural products remain elusive, often overshadowed by structural simplification approaches. Herein, we report the molecular redesign of an antitumor drug, ecteinascidin 743, which achieves three pivotal objectives: (1) strategic shift of the bridgehead position from C4 to C5, (2) systematic customization of macrocycle size, and (3) incorporation of functional groups for further modification. Our approach generates diverse 14- to 17-membered macrocyclic frameworks bridged at C5, expanding the accessible chemical space beyond that of conventional C1- to C4-bridged scaffolds, while preserving the core structure essential for covalent DNA interactions. These novel macrocycles induce DNA double-strand breaks and exhibit sub-nanomolar anticancer efficacy comparable to ecteinascidins. This method shortens the conventional 21-step semi-synthetic protocol into a streamlined 6- to 10-step process, cutting the synthetic burden by over 50%.","PeriodicalId":268,"journal":{"name":"Chem","volume":"9 1","pages":""},"PeriodicalIF":23.5,"publicationDate":"2025-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144652626","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Production of biorenewable, enantiopure (S)-3-hydroxy-γ-butyrolactone for pharmaceutical applications 生物可再生、对映纯(S)-3-羟基-γ-丁内酯的生产

IF 23.5 1区化学

Chem Pub Date : 2025-07-18 DOI: 10.1016/j.chempr.2025.102665

Justin O.P. Waters, Elnaz Jamalzade, Hussein T. Abdulrazzaq, Nathaniel Kuch, Sampath R. Gunukula, James A. Dumesic, Philip J. Kersten, Thomas J. Schwartz

{"title":"Production of biorenewable, enantiopure (S)-3-hydroxy-γ-butyrolactone for pharmaceutical applications","authors":"Justin O.P. Waters, Elnaz Jamalzade, Hussein T. Abdulrazzaq, Nathaniel Kuch, Sampath R. Gunukula, James A. Dumesic, Philip J. Kersten, Thomas J. Schwartz","doi":"10.1016/j.chempr.2025.102665","DOIUrl":"https://doi.org/10.1016/j.chempr.2025.102665","url":null,"abstract":"Many pharmaceuticals include chiral centers, which are introduced using high-cost building blocks such as (S)-3-hydroxy-γ-butyrolactone, (S)-HBL. This species is used in the synthesis of many important drugs, including statins, antibiotics, and HIV inhibitors, and it is currently produced from fossil resources via a high-cost, high-emission process. Here, we show that a nearly quantitative yield of enantiopure (S)-HBL can be obtained from glucose at ambient temperature, using a combination of biological and chemical catalysis. Whole-cell enzyme catalysis converts glucose to a labile intermediate (denoted as trione) that is subsequently reacted to (S)-HBL by metal-free homogeneous acid/base catalysis. These reactions do not involve the C5 of glucose, leading to enantiopure (S)-HBL, produced at less than half the present cost. This approach can also be used to produce other commercially important building blocks from sustainable feedstocks: the enzymes used for trione production are active in converting xylose, leading to the acrylate co-monomer 3-hydroxypropionic acid.","PeriodicalId":268,"journal":{"name":"Chem","volume":"677 1","pages":""},"PeriodicalIF":23.5,"publicationDate":"2025-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144652643","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Chiral C3-symmetric molecule assembly enabling topological nanotoroid, fused nanotoroid, and nanocatenane 手性c3对称分子组装实现拓扑纳米环、融合纳米环和纳米正烯

IF 23.5 1区化学

Chem Pub Date : 2025-07-15 DOI: 10.1016/j.chempr.2025.102663

Jinqi Li, Huajie Zhu, Hanxiao Wang, Chenyang Zhao, Guanghui Ouyang, Minghua Liu

{"title":"Chiral C3-symmetric molecule assembly enabling topological nanotoroid, fused nanotoroid, and nanocatenane","authors":"Jinqi Li, Huajie Zhu, Hanxiao Wang, Chenyang Zhao, Guanghui Ouyang, Minghua Liu","doi":"10.1016/j.chempr.2025.102663","DOIUrl":"https://doi.org/10.1016/j.chempr.2025.102663","url":null,"abstract":"Although chiral nanostructures have been extensively studied, the fabrication of topological entities such as toroidal assemblies and their higher-order fused or catenated structures remains a formidable challenge. Here, we demonstrate a hierarchical assembly paradigm using a C3-symmetric benzene-1,3,5-tricarboxamide that enables the topological evolution of varied nanoarchitectures, such as discrete nanotoroids, fused super-nanotoroids containing up to 21 toroidal units, and nano-[2]catenanes. Our experimental and calculation results demonstrated that C3 molecules tended to form helical nanofibers with unexpected curvature due to both molecular chirality and bulky side chains. Further longitudinal extension and lateral lamellar packing of primary one-dimensional stacks led to the formation of dominant nanotoroids and stochastic nano-[2]catenanes with chiroptical signals and circularly polarized luminescence through an adaptive templating method. This work presents a cyclization-driven precise assembly of topologically discrete, fused, and catenated nanotoroids, unveiling the synergistic merging of chiral hierarchy and topological architectures in supramolecular self-assembly systems.","PeriodicalId":268,"journal":{"name":"Chem","volume":"21 1","pages":""},"PeriodicalIF":23.5,"publicationDate":"2025-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144630084","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Curved anthracenes for visible-light photon energy storage via Dewar isomerization 弯曲蒽用于杜瓦异构化的可见光光子储能

IF 23.5 1区化学

Chem Pub Date : 2025-07-15 DOI: 10.1016/j.chempr.2025.102660

Subhayan Chakraborty, Writam S.R. Choudhuri, Junichi Usuba, Qianfeng Qiu, Cijil Raju, Grace G.D. Han

引用次数: 0

Suppressing molecular motions: A pathway to enhanced organic room temperature phosphorescence 抑制分子运动：增强有机室温磷光的途径

IF 23.5 1区化学

Chem Pub Date : 2025-07-14 DOI: 10.1016/j.chempr.2025.102654

Chensen Li, Minghui Wu, Zheng Zhao, Jacky W.Y. Lam, Bo Xu, Ben Zhong Tang

引用次数: 0

From chiral biomolecules to chiral nanocrystals: A review of the latest developments and emerging concepts 从手性生物分子到手性纳米晶体：最新发展和新兴概念综述

IF 19.1 1区化学

Chem Pub Date : 2025-07-10 DOI: 10.1016/j.chempr.2025.102544

Yisen Yao , Oscar Ávalos-Ovando , Tao Ding , Ramon A. Alvarez-Puebla , Peng Yu , Eric Ashalley , Li Ma , Zhiming Wang , Gil Markovich , Alexander O. Govorov

{"title":"From chiral biomolecules to chiral nanocrystals: A review of the latest developments and emerging concepts","authors":"Yisen Yao , Oscar Ávalos-Ovando , Tao Ding , Ramon A. Alvarez-Puebla , Peng Yu , Eric Ashalley , Li Ma , Zhiming Wang , Gil Markovich , Alexander O. Govorov","doi":"10.1016/j.chempr.2025.102544","DOIUrl":"10.1016/j.chempr.2025.102544","url":null,"abstract":"<div><div>This article reviews the latest developments in the field of chiral nanocrystals (NCs), focusing primarily on plasmonic NCs. Such nanomaterials under illumination concentrate electromagnetic energy in their vicinity, enabling efficient biosensing, asymmetric photocatalysis, and light manipulation. Starting our discussion with Lord Kelvin’s definition of chirality, we describe how enantiomer pairs appear when the molecule becomes progressively more complex. Making a comparison with Pasteur’s chirality of molecules, we discuss nanoscale enantiomers lacking exact mirror symmetry, so-called nonexact enantiomers, and why they should appear fundamentally. Whereas chirality is an intrinsically three-dimensional (3D) concept describing perfect mirror-imaged pairs, a novel property of pseudo-chirality is handy for understanding two-dimensional (2D) systems, including the case of plasmonic growth with circularly polarized light. The topics considered in the review include bio-templated NCs, chiral bio-assemblies, transfer of chirality from biomolecules to NCs, chirality and pseudo-chirality in 3D and 2D systems, growth of NCs under circularly polarized excitation, and more.</div></div>","PeriodicalId":268,"journal":{"name":"Chem","volume":"11 7","pages":"Article 102544"},"PeriodicalIF":19.1,"publicationDate":"2025-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143890224","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0