Synthesis and assembly strategy of electroactive biomaterials and systems for soft tissue engineering applications

IF 19.1 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Chem Pub Date : 2025-05-19 DOI:10.1016/j.chempr.2025.102596

Dong Yang, Yi Hu, Shuai Liu, Wenhui Yang, Xi Ren, Yanbing Li, Feng Xu, Min Gong, Yunlong Zhao, Xiaozhong Qiu, Honghao Hou

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Abstract

Soft tissue injuries are a common issue affecting human health, and the extent and duration of injuries often constrain the healing process. Electroactive biomaterials have become a key medium for tissue regeneration by modulating cellular behavior, but a systematic evaluation of their potential and challenges is still limited. This review comprehensively explores electroactive biomaterials, focusing on their chemical synthesis, assembly processes, application potential, challenges faced, and future directions. First, this work elaborates on the unique and innovative features of electroactive biomaterials’ chemical synthesis and preparation techniques. Subsequently, the principles of electroactive devices and their interactions with biological tissues are described to optimize tissue repair. Finally, the application prospects of electrical stimulation technology in soft tissue engineering are explored, emphasizing its role in cell and tissue regeneration and its clinical potential. In conclusion, this review provides theoretical and practical insights into the development and application of electroactive biomaterials.

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用于软组织工程的电活性生物材料和系统的合成与装配策略

软组织损伤是影响人类健康的常见问题，损伤的程度和持续时间往往制约着愈合过程。电活性生物材料通过调节细胞行为已成为组织再生的关键介质，但对其潜力和挑战的系统评估仍然有限。本文综述了电活性生物材料的化学合成、组装工艺、应用潜力、面临的挑战和未来发展方向。首先，阐述了电活性生物材料化学合成与制备技术的独特性和创新性。随后，描述了电活性装置的原理及其与生物组织的相互作用，以优化组织修复。最后，探讨了电刺激技术在软组织工程中的应用前景，强调了电刺激技术在细胞和组织再生中的作用及其临床应用潜力。综上所述，本文对电活性生物材料的发展和应用提供了理论和实践的见解。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Chem Environmental Science-Environmental Chemistry

CiteScore

32.40

自引率

1.30%

发文量

281

期刊介绍： Chem, affiliated with Cell as its sister journal, serves as a platform for groundbreaking research and illustrates how fundamental inquiries in chemistry and its related fields can contribute to addressing future global challenges. It was established in 2016, and is currently edited by Robert Eagling.