Construction of axially chiral heterobiaryls via Rh-catalyzed atroposelective single-carbon insertion

The catalytic asymmetric single-atom skeletal editing of heteroarenes is highly desirable but very challenging. In the Journal of the American Chemical Society, Suero, Maseras, and co-workers establish a Rh-catalyzed asymmetric single-carbon insertion to convert readily available 3-arylindoles into axially chiral 4-arylquinolines with excellent enantiocontrol, providing a new strategy for the atroposelective construction of axially chiral heterobiaryls.