IF 19.6 1区化学

Chem Pub Date : 2026-04-09 Epub Date: 2025-11-17 DOI: 10.1016/j.chempr.2025.102819

Tao Zhou , Long Chen , Haikuo Zhang , Ruhong Li , Shuoqing Zhang , Baochen Ma , Jinze Wang , Jiajie Huang , Haotian Zhu , Junyi Hua , Zeyuan Liu , Hao Zhang , Kun Wang , Lixin Chen , Tao Deng , Xiulin Fan

{"title":"Tuning interfacial solvent orientation for high-voltage lithium-ion batteries","authors":"Tao Zhou , Long Chen , Haikuo Zhang , Ruhong Li , Shuoqing Zhang , Baochen Ma , Jinze Wang , Jiajie Huang , Haotian Zhu , Junyi Hua , Zeyuan Liu , Hao Zhang , Kun Wang , Lixin Chen , Tao Deng , Xiulin Fan","doi":"10.1016/j.chempr.2025.102819","DOIUrl":"10.1016/j.chempr.2025.102819","url":null,"abstract":"<div><div>Elevating the charging cutoff voltage of lithium cobalt oxide (LCO) cathodes boosts the energy density of lithium-ion batteries (LIBs) but induces severe electrolyte decomposition. While additives can mitigate this by forming protective cathode electrolyte interphase (CEI), the design principles remain poorly understood. Herein, we propose an additive-mediated solvent orientation modulation strategy to tailor the interfacial molecular arrangement. Density functional theory (DFT) calculations reveal that ethylene carbonate (EC) that is aligned parallel to the LCO surface undergoes spontaneous dehydrogenation, whereas a perpendicular orientation is significantly more oxidation resistant. The designed additive, pentafluorophenyl trifluoromethanesulfonate (PFBS), preferentially adsorbs on the LCO surface and enforces a stable perpendicular EC orientation via phenyl-carbonyl interactions. This modulation suppresses EC decomposition and promotes an inorganic-rich CEI. With 1% PFBS, 4.55 V graphite||LCO full cells exhibit excellent cycling performance at both ambient and elevated temperatures. This work pioneers a new paradigm for electrolyte additive design at the molecular level.</div></div>","PeriodicalId":268,"journal":{"name":"Chem","volume":"12 4","pages":"Article 102819"},"PeriodicalIF":19.6,"publicationDate":"2026-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145531552","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

ReCHEMbinant stapling enhances intracellular delivery and bioactivity of engineered protein inhibitors ReCHEMbinant钉接增强了工程蛋白抑制剂的细胞内递送和生物活性

IF 19.6 1区化学

Chem Pub Date : 2026-04-09 Epub Date: 2025-12-17 DOI: 10.1016/j.chempr.2025.102839

Jan Pascal Kahler , Brecht D. Ellenbroek , Vera E. van der Noord , Bob van de Water , Sebastian J. Pomplun

{"title":"ReCHEMbinant stapling enhances intracellular delivery and bioactivity of engineered protein inhibitors","authors":"Jan Pascal Kahler , Brecht D. Ellenbroek , Vera E. van der Noord , Bob van de Water , Sebastian J. Pomplun","doi":"10.1016/j.chempr.2025.102839","DOIUrl":"10.1016/j.chempr.2025.102839","url":null,"abstract":"<div><div>Protein therapeutics have transformed drug discovery by enabling modulation of challenging targets inaccessible to small molecules. However, most proteins lack the ability to penetrate cells, where many critical drug targets reside. Here, we present reCHEMbinant protein engineering, a strategy designed to generate synthetically enhanced proteins with improved structural stability, serum resistance, and cellular uptake. Applying this approach to Omomyc, a protein-based MYC inhibitor, we developed several reCHEMbinant stapled variants (HeloMYCs) exhibiting low-nanomolar DNA-binding affinity. Notably, the <em>i</em>, <em>i</em> + 7 biphenyl-stapled construct HeloMYC-1421 outperformed Omomyc across several functional assays, including potent inhibition of MYC-driven gene expression in luciferase reporter assays and selective antiproliferative effects in MYC-dependent cells. Live-cell imaging showed that these enhanced effects result from significantly improved cellular uptake. Transcriptional reprogramming was further confirmed by RNA sequencing (RNA-seq). Together, our findings establish reCHEMbinant engineering as a chemically defined strategy for stapling entire recombinant proteins to enhance their intracellular bioactivity.</div></div>","PeriodicalId":268,"journal":{"name":"Chem","volume":"12 4","pages":"Article 102839"},"PeriodicalIF":19.6,"publicationDate":"2026-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147636779","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Genetically engineered peptides for the biomimetic mineralization of metal-organic frameworks 用于金属-有机框架仿生矿化的基因工程肽

IF 19.6 1区化学

Chem Pub Date : 2026-04-09 Epub Date: 2026-02-02 DOI: 10.1016/j.chempr.2025.102865

Smaragda Lymperopoulou , Samuel Hoff , Anna Sola-Rabada , Monika Michaelis , Igor Efimov , Zayd C. Westcott , India J. Willimott , Mauro Chiacchia , Hendrik Heinz , Carole C. Perry , Darren Bradshaw

{"title":"Genetically engineered peptides for the biomimetic mineralization of metal-organic frameworks","authors":"Smaragda Lymperopoulou , Samuel Hoff , Anna Sola-Rabada , Monika Michaelis , Igor Efimov , Zayd C. Westcott , India J. Willimott , Mauro Chiacchia , Hendrik Heinz , Carole C. Perry , Darren Bradshaw","doi":"10.1016/j.chempr.2025.102865","DOIUrl":"10.1016/j.chempr.2025.102865","url":null,"abstract":"<div><div>The biomimetic mineralization of metal-organic frameworks (MOFs) is a promising synthetic strategy for MOF and hybrid bio-MOF composites and has significant potential in a variety of applications. Although interactions between MOFs and several biological materials have been extensively studied, interactions between MOFs and peptides remain unexplored. Here, we used phage display to identify strongly binding peptides for isoreticular MOFs (UiO-66 and UiO-66-NH<sub>2</sub>). Zeta potential (ZP) and circular dichroism (CD) spectroscopy measurements, combined with molecular dynamics (MD) simulations, enabled us to characterize and explain the structure and dynamics of the MOF-binding peptides, as well as differences in conformation and binding coefficients, thereby allowing determination of the MOF-peptide recognition mechanisms. We also successfully used the peptides to control MOF crystallinity and morphology for Zr-based MOFs under synthesis conditions where amorphous products form in their absence. Our findings have significant implications for understanding MOF-peptide interactions, which will be critical for designing and controlling MOF structures and for bio-centered applications.</div></div>","PeriodicalId":268,"journal":{"name":"Chem","volume":"12 4","pages":"Article 102865"},"PeriodicalIF":19.6,"publicationDate":"2026-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146101828","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Transforming plastics at the interface: Electrochemical re- and upcycling strategies 在界面上转化塑料：电化学再循环和升级回收策略

IF 19.6 1区化学

Chem Pub Date : 2026-04-09 Epub Date: 2026-03-27 DOI: 10.1016/j.chempr.2026.102997

Sven Erik Peters , Maxime Hourtoule , Georgina Kirby , Lutz Ackermann

引用次数: 0

Light-intensity-dependent out-of-equilibrium processes toward dimensionally distinct nanopolymorphs 光强度相关的非平衡过程对尺寸不同的纳米多晶

IF 19.6 1区化学

Chem Pub Date : 2026-04-09 Epub Date: 2025-11-17 DOI: 10.1016/j.chempr.2025.102818

Kenta Tamaki , Hiroki Hanayama , Sougata Datta , Fabien Silly , Yuki Wada , Daisuke Hashizume , Kiyohiro Adachi , Takayuki Uchihashi , Masaki Kawano , Christian Ganser , Shiki Yagai

{"title":"Light-intensity-dependent out-of-equilibrium processes toward dimensionally distinct nanopolymorphs","authors":"Kenta Tamaki , Hiroki Hanayama , Sougata Datta , Fabien Silly , Yuki Wada , Daisuke Hashizume , Kiyohiro Adachi , Takayuki Uchihashi , Masaki Kawano , Christian Ganser , Shiki Yagai","doi":"10.1016/j.chempr.2025.102818","DOIUrl":"10.1016/j.chempr.2025.102818","url":null,"abstract":"<div><div>Molecular assemblies that form distinct out-of-equilibrium states in response to varying energy inputs represent a promising platform for designing advanced, autonomous adaptive materials capable of flexibly and diversely responding to environmental stimuli. Herein, we describe a supramolecular polymer system that integrates azobenzene photoisomerization with hydrogen-bond-directed supramolecular polymorphism, enabling the formation of distinct out-of-equilibrium states under varied light intensities. <em>t</em><em>rans</em> isomers of an azobenzene derivative featuring a barbituric acid merocyanine unit self-assemble into lamellar crystals via two-dimensional nanosheet stacking. Ultraviolet light irradiation of a nanosheet dispersion in nonpolar media at different intensities modulates the proportion of <em>cis</em> isomers, eliciting unique out-of-equilibrium states. Specifically, a strong light facilitates the coassembly of <em>trans</em> and <em>cis</em> isomers into one-dimensional nanofibers through hydrogen bond rearrangement, whereas weaker light drives Ostwald ripening, transforming two-dimensional nanosheets into three-dimensional multilayered structures. High-speed atomic force microscopy reveals the intricate dynamic processes driving these transitions.</div></div>","PeriodicalId":268,"journal":{"name":"Chem","volume":"12 4","pages":"Article 102818"},"PeriodicalIF":19.6,"publicationDate":"2026-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145531587","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Electrifying depolymerization back to monomers 通电解聚回单体

IF 19.6 1区化学

Chem Pub Date : 2026-04-09 Epub Date: 2026-03-24 DOI: 10.1016/j.chempr.2026.103005

Arnaud Thevenon

引用次数: 0

In situ cryogenic X-ray photoelectron spectroscopy unveils metastable components of the solid electrolyte interphase in Li-ion batteries 原位低温x射线光电子能谱揭示了锂离子电池中固体电解质界面的亚稳态成分

IF 19.6 1区化学

Chem Pub Date : 2026-04-09 Epub Date: 2025-12-16 DOI: 10.1016/j.chempr.2025.102837

Dan-Thien Nguyen , Venkateshkumar Prabhakaran , Vaithiyalingam Shutthanandan , Karl T. Mueller , Vijayakumar Murugesan

{"title":"In situ cryogenic X-ray photoelectron spectroscopy unveils metastable components of the solid electrolyte interphase in Li-ion batteries","authors":"Dan-Thien Nguyen , Venkateshkumar Prabhakaran , Vaithiyalingam Shutthanandan , Karl T. Mueller , Vijayakumar Murugesan","doi":"10.1016/j.chempr.2025.102837","DOIUrl":"10.1016/j.chempr.2025.102837","url":null,"abstract":"<div><div>Identifying the intrinsic chemical composition of the solid electrolyte interphase (SEI) in Li-ion batteries has long been a challenging endeavor. Herein, we have developed a state-of-the-art cryogenic X-ray photoelectron spectroscopy (XPS) system integrated with residual gas analysis to capture the metastable components of the SEI. This advanced configuration enables instantaneous freezing of the cycled graphite electrode, followed by monitoring of the surface evolution and gas release as the electrode transitions from cryogenic temperature to room temperature. Our findings reveal that lithium fluorophosphate is the primary decomposition product of lithium hexafluorophosphate, which rapidly degrades into LiF and POF<sub>3</sub> upon transitioning out of the cryogenic state. Utilizing this experimental setup, we identified critical experimental parameters that can lead to measurement artifacts, including prolonged exposure to ultrahigh vacuum conditions, improper neutralizer control, and inadequate sample-drying protocols. Careful management of these factors will ensure reliable and reproducible XPS measurements for battery-related materials, and our findings highlight best practices for such analyses.</div></div>","PeriodicalId":268,"journal":{"name":"Chem","volume":"12 4","pages":"Article 102837"},"PeriodicalIF":19.6,"publicationDate":"2026-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145760254","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Divergent covalent organic frameworks as antenna reactors for photoredox catalysis 发散共价有机框架作为天线反应器用于光氧化还原催化

IF 19.6 1区化学

Chem Pub Date : 2026-04-09 Epub Date: 2026-02-02 DOI: 10.1016/j.chempr.2025.102864

Ting He , Ziyue Huang , Zhongzheng Zhang , Jingjing Guo , Yuanyuan Guo , Brynne Shu Ni Tan , Shihuai Wang , Yanping Wei , Yinglong Wu , Xinkun Ma , Wenbin Zhong , Yanli Zhao

{"title":"Divergent covalent organic frameworks as antenna reactors for photoredox catalysis","authors":"Ting He , Ziyue Huang , Zhongzheng Zhang , Jingjing Guo , Yuanyuan Guo , Brynne Shu Ni Tan , Shihuai Wang , Yanping Wei , Yinglong Wu , Xinkun Ma , Wenbin Zhong , Yanli Zhao","doi":"10.1016/j.chempr.2025.102864","DOIUrl":"10.1016/j.chempr.2025.102864","url":null,"abstract":"<div><div>Photoredox catalysis is a useful toolbox for organic synthetic chemistry through not only creating more possibilities for the known reactions but also developing new pathways for the inaccessible compounds. The development of transition metal complexes greatly boosts this field, while there remain a variety of challenges such as poor photostability, non-recyclability, limited activity, and red-light inaccessibility. Herein, we develop a divergent strategy to construct covalent organic frameworks (COFs) featuring dense and aligned porphyrin antenna and docking sites. Various metal species are well immobilized on the pore walls of COFs to form antenna-reactor structures COF-M (M = Ir, Ru, and Cu) with good photostability and recyclability. The segregated porphyrin donor and metal complex acceptor promote the separation and suppress the recombination of photo-induced charge carriers. As a result, the as-prepared COF-M presents high activity toward several reactions, including photocatalytic [2 + 2] cycloadditions, trifluoromethylation reactions, and reductive pinacol-type couplings.</div></div>","PeriodicalId":268,"journal":{"name":"Chem","volume":"12 4","pages":"Article 102864"},"PeriodicalIF":19.6,"publicationDate":"2026-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146101830","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Light-driven reversible ring contraction and expansion to modulate strain, conformation, and reactivity 光驱动可逆环收缩和膨胀调节应变，构象和反应性

IF 19.6 1区化学

Chem Pub Date : 2026-04-09 Epub Date: 2026-03-16 DOI: 10.1016/j.chempr.2026.102947

Tom Bösking , Denise Schwarz , Daniel Aßenmacher , Oliver Fiukowski , Michael Pohl , Mike Pauls , Christoph Bannwarth , Dušan Kolarski , Stefan Hecht

{"title":"Light-driven reversible ring contraction and expansion to modulate strain, conformation, and reactivity","authors":"Tom Bösking , Denise Schwarz , Daniel Aßenmacher , Oliver Fiukowski , Michael Pohl , Mike Pauls , Christoph Bannwarth , Dušan Kolarski , Stefan Hecht","doi":"10.1016/j.chempr.2026.102947","DOIUrl":"10.1016/j.chempr.2026.102947","url":null,"abstract":"<div><div>Chemists utilize cyclic constraints in molecules to control conformation, shape, and reactivity. The strain introduced in the (macro)cycles is released during reactions and drives transformations ranging from strain-promoted <em>in vivo</em> ligation to ring-opening metathesis polymerization. However, in each case, the ring size needs careful optimization and cannot be (re)adjusted. For remote optical modulation of strain, we designed looped diarylethene photoswitches that undergo reversible ring contraction/expansion upon electrocyclic ring closure/opening. Investigating a homologous series, we discovered that the long-wavelength absorption of the closed isomer serves as a diagnostic tool for stored molecular strain. By incorporating an internal allene reactive group in the loop, we enhanced its reactivity in a [3+2] dipolar cycloaddition with ethyl diazoacetate under visible light. Quantum chemical calculations helped rationalize the experimentally observed size-dependent photochemistry and reactivity of the macrocycles. Our approach opens opportunities for optical spatiotemporal reactivity control in life and materials science applications.</div></div>","PeriodicalId":268,"journal":{"name":"Chem","volume":"12 4","pages":"Article 102947"},"PeriodicalIF":19.6,"publicationDate":"2026-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147490076","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Advanced organic electrosynthesis empowered by single-atom catalysis 先进的有机电合成授权的单原子催化

IF 19.6 1区化学

Chem Pub Date : 2026-04-09 Epub Date: 2026-01-27 DOI: 10.1016/j.chempr.2025.102838

Zezhao Li , Chang-Jie Yang , Wan-Jie Wei , Meiqi Zhu , Tianyou Zhao , Qixuan Zhang , Yong-Zhou Pan , Jiarui Yang , Xin-Yu Wang , Hai-Tao Tang , Wen-Hao Li , Dingsheng Wang

{"title":"Advanced organic electrosynthesis empowered by single-atom catalysis","authors":"Zezhao Li , Chang-Jie Yang , Wan-Jie Wei , Meiqi Zhu , Tianyou Zhao , Qixuan Zhang , Yong-Zhou Pan , Jiarui Yang , Xin-Yu Wang , Hai-Tao Tang , Wen-Hao Li , Dingsheng Wang","doi":"10.1016/j.chempr.2025.102838","DOIUrl":"10.1016/j.chempr.2025.102838","url":null,"abstract":"<div><div>Organic electrosynthesis technology provides new ideas for the development of green organic synthesis, and the rational selection of electrode materials and electrocatalysts creates new opportunities for smart electrosynthesis. The study of electrode materials and electrocatalysts at the atomic scale forms the basis for the development of efficient electroorganic synthesis materials by enabling a fundamental understanding of microscopic reaction active sites. Research on the application of single-atom catalysts (SACs) in electroorganic synthesis has advanced the field, but their actual mechanisms of action in electrosynthesis remain insufficiently understood. This review summarizes recent advances in the application of SACs to organic electrosynthesis, including the preparation of electrode materials, performance in typical electrosynthetic systems, and <em>in situ</em> techniques for probing structure-activity relationships. It concludes by outlining the opportunities and challenges facing the field.</div></div>","PeriodicalId":268,"journal":{"name":"Chem","volume":"12 4","pages":"Article 102838"},"PeriodicalIF":19.6,"publicationDate":"2026-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147636780","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

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