Chem最新文献_第4页

Molecule-resolvable SERSome for metabolic profiling 用于代谢谱分析的分子可分辨的SERSome

IF 19.6 1区化学

Chem Pub Date : 2025-09-11 DOI: 10.1016/j.chempr.2025.102528

Xinyuan Bi , Xiaohang Qian , Bingsen Xue , Miao Zhang , Shuyu Liu , Haoran Chen , Cheng Jin , Huidong Tang , Jian Ye

{"title":"Molecule-resolvable SERSome for metabolic profiling","authors":"Xinyuan Bi , Xiaohang Qian , Bingsen Xue , Miao Zhang , Shuyu Liu , Haoran Chen , Cheng Jin , Huidong Tang , Jian Ye","doi":"10.1016/j.chempr.2025.102528","DOIUrl":"10.1016/j.chempr.2025.102528","url":null,"abstract":"<div><div>Multiplexed detection is a challenging yet essential task in analytical chemistry, especially for complex systems. Surface-enhanced Raman spectroscopy (SERS) is a promising analytical tool due to its molecular fingerprinting capability, sensitivity, low cost, and tractability. Considering the molecular profusion and diversity, SERSome, namely, spectral set, facilitates robust detection but is still challenged by spectral overlapping-induced uncertainty of molecular assignment and multiplexed quantification. Herein, we introduce molecule-resolvable (MORE) SERSome, identifying specific analytes contributing to the complex SERS spectra, which are then used in spectral decomposition for multiplexed analysis. Taking metabolic profiling for Alzheimer’s disease as a proof of concept, ten metabolites are screened in human serum. A deep-learning model enables accurate and rapid diagnosis, achieving an area under the receiver operating characteristic curve as high as 91.5%. Comparing with conventional methods, MORE SERSome presents a methodological advancement in multiplexed detection with strong potential for general applications and fundamental research in analytical chemistry.</div></div>","PeriodicalId":268,"journal":{"name":"Chem","volume":"11 9","pages":"Article 102528"},"PeriodicalIF":19.6,"publicationDate":"2025-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143776224","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Depositing atom by atom: Pt–Ru–Co triple-atom catalysts 逐个原子沉积：Pt-Ru-Co三原子催化剂

IF 19.6 1区化学

Chem Pub Date : 2025-09-11 DOI: 10.1016/j.chempr.2025.102746

Hyunjoo Lee

引用次数: 0

Stable and responsive atropisomerism around a carbon–iodine bond 碳-碘键周围稳定且反应迅速的反旋异构

IF 19.6 1区化学

Chem Pub Date : 2025-09-11 DOI: 10.1016/j.chempr.2025.102527

Shohei Abe , Jun Kikuchi , Arimasa Matsumoto , Naohiko Yoshikai

引用次数: 0

One-dimensional lead halide perovskite quantum ribbons with controllable edge terminations and ribbon widths 具有可控制边缘端点和能带宽度的一维卤化铅钙钛矿量子带

IF 19.6 1区化学

Chem Pub Date : 2025-09-11 DOI: 10.1016/j.chempr.2025.102548

Xiaofan Jiang , Mingyuan Li , Yu Tao , Meng Zhang , Xinyu Li , Tianhao Zhang , Jiazhen Gu , Guangsheng Bai , Nanlong Zheng , Xuan Zhao , Huilong Hong , Leyang Jin , Xu Huang , Sanli Xu , Yan Guan , Chen Li , Wenkai Zhang , Yongping Fu

{"title":"One-dimensional lead halide perovskite quantum ribbons with controllable edge terminations and ribbon widths","authors":"Xiaofan Jiang , Mingyuan Li , Yu Tao , Meng Zhang , Xinyu Li , Tianhao Zhang , Jiazhen Gu , Guangsheng Bai , Nanlong Zheng , Xuan Zhao , Huilong Hong , Leyang Jin , Xu Huang , Sanli Xu , Yan Guan , Chen Li , Wenkai Zhang , Yongping Fu","doi":"10.1016/j.chempr.2025.102548","DOIUrl":"10.1016/j.chempr.2025.102548","url":null,"abstract":"<div><div>One-dimensional (1D) halide<span><span> perovskite quantum ribbons, featuring 1D corner-sharing octahedral networks, are promising for optoelectronics<span> and photonics due to quantum confinement in two dimensions. However, the rational design of 1D perovskites remains challenging, and existing materials with narrow ribbon widths predominantly form self-trapped excitons, which limit their potential applications. Here, we synthesize 30 1D perovskites with controllable ribbon widths and edge octahedra terminations by </span></span>organic cation<span> engineering. We observe the absence of self-trapped excitons as the ribbon width increases up to four octahedra, alongside the ability to modulate their optoelectronic properties by tailoring the edge terminations. The 1D free excitons result in in-plane anisotropic photoluminescence (PL) emission with polarization degree reaching 60%. Moreover, we observe robust exciton-photon coupling with Rabi splitting energies up to 800 meV, which is significantly larger than those of three-dimensional (3D) and two-dimensional (2D) perovskites, demonstrating a class of 1D quantum materials for advanced optoelectronics and photonics.</span></span></div></div>","PeriodicalId":268,"journal":{"name":"Chem","volume":"11 9","pages":"Article 102548"},"PeriodicalIF":19.6,"publicationDate":"2025-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143832147","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Synergistic nanotherapy enhances tumor and lymph node immunity 协同纳米疗法增强肿瘤和淋巴结免疫

IF 19.6 1区化学

Chem Pub Date : 2025-09-11 DOI: 10.1016/j.chempr.2025.102747

Xu Guan , Xin Zhang , Xishan Wang

引用次数: 0

Rate-limiting regimes in photochemical H2 generation by complexes of colloidal CdS nanorods and hydrogenase 胶体CdS纳米棒与氢化酶配合物光化学制氢的限速机制

IF 19.6 1区化学

Chem Pub Date : 2025-09-11 DOI: 10.1016/j.chempr.2025.102594

Helena R. Keller , James K. Utterback , Hayden Hamby , Carolyn E. Lubner , David W. Mulder , Paul W. King , Gordana Dukovic

{"title":"Rate-limiting regimes in photochemical H2 generation by complexes of colloidal CdS nanorods and hydrogenase","authors":"Helena R. Keller , James K. Utterback , Hayden Hamby , Carolyn E. Lubner , David W. Mulder , Paul W. King , Gordana Dukovic","doi":"10.1016/j.chempr.2025.102594","DOIUrl":"10.1016/j.chempr.2025.102594","url":null,"abstract":"<div><div><span>Driving redox enzyme catalysis with photoexcited semiconductor nanocrystals is a compelling approach for chemical conversion. We examined how the interplay of the many chemical steps involved determines the rates of photochemical H</span><sub>2</sub><span> production with complexes of colloidal CdS nanorods<span> and an [FeFe]-hydrogenase. We elucidated the roles of three critical and previously elusive processes—scavenging of photoexcited holes from nanorods, back-electron transfer, and H</span></span><sub>2</sub><span><span> oxidation. Kinetic </span>Monte Carlo simulations and fitting to experimental data revealed that hole transfer becomes the rate-limiting step at high illumination intensities. Comparisons of simulations to experimental H</span><sub>2</sub> production showed that both back-electron transfer and H<sub>2</sub><span><span> oxidation play an efficiency-limiting role at high catalyst loadings. This work provides guiding principles for tuning experimental parameters to minimize energy-wasting pathways and optimize photochemical product formation. More broadly, we demonstrate how critical but elusive chemical steps in </span>photochemical reactions can be probed with a combination of experiments and simulations.</span></div></div>","PeriodicalId":268,"journal":{"name":"Chem","volume":"11 9","pages":"Article 102594"},"PeriodicalIF":19.6,"publicationDate":"2025-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144122861","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Reaction: Of myths, misconceptions, and motors—A matter of equilibrium 反应：神话、误解和动力——一个平衡的问题

IF 19.6 1区化学

Chem Pub Date : 2025-09-11 DOI: 10.1016/j.chempr.2025.102745

David A. Leigh

引用次数: 0

Toward synthetic life—Emergence, growth, creation of offspring, decay, and rescue of fuel-dependent synthetic cells 走向合成生命——依赖燃料的合成细胞的出现、生长、后代的创造、衰变和拯救

IF 19.6 1区化学

Chem Pub Date : 2025-09-11 DOI: 10.1016/j.chempr.2025.102578

Monika Wenisch , Yinqing Li , Marius G. Braun , Lukas Eylert , Fabian Späth , Simone M. Poprawa , Bernhard Rieger , Christopher V. Synatschke , Henrike Niederholtmeyer , Job Boekhoven

{"title":"Toward synthetic life—Emergence, growth, creation of offspring, decay, and rescue of fuel-dependent synthetic cells","authors":"Monika Wenisch , Yinqing Li , Marius G. Braun , Lukas Eylert , Fabian Späth , Simone M. Poprawa , Bernhard Rieger , Christopher V. Synatschke , Henrike Niederholtmeyer , Job Boekhoven","doi":"10.1016/j.chempr.2025.102578","DOIUrl":"10.1016/j.chempr.2025.102578","url":null,"abstract":"<div><div>The <em>de novo</em> synthesis of life from non-living matter represents a bold scientific challenge, advancing our understanding of life’s minimal requirements and offering revolutionary applications in biotechnology. We explore fuel-dependent synthetic cells based on complex coacervate droplets, which lack membranes and readily take up reactants. Given their fuel-dependent nature, these droplets emerge and grow when fuel is abundant but dissolve under starvation conditions, mimicking the non-equilibrium nature of life. However, their ability to produce offspring—a key requirement for life—has remained elusive. Moreover, their rescue in repetitive fueling-starvation experiments has not been demonstrated. Our work elucidates a mechanism of producing offspring by synthetic cells driven by solid-like speckles in droplets liberated as offspring. By fine-tuning parameters, we control offspring number and survival. Finally, refueling sustains second-generation synthetic cells. This system provides a platform for coupling offspring production with self-replicating molecules, paving the way for synthetic cells capable of Darwinian evolution.</div></div>","PeriodicalId":268,"journal":{"name":"Chem","volume":"11 9","pages":"Article 102578"},"PeriodicalIF":19.6,"publicationDate":"2025-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143927098","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Synthesis and assembly strategy of electroactive biomaterials and systems for soft tissue engineering applications 用于软组织工程的电活性生物材料和系统的合成与装配策略

IF 19.6 1区化学

Chem Pub Date : 2025-09-11 DOI: 10.1016/j.chempr.2025.102596

Dong Yang , Yi Hu , Shuai Liu , Wenhui Yang , Xi Ren , Yanbing Li , Feng Xu , Min Gong , Yunlong Zhao , Xiaozhong Qiu , Honghao Hou

{"title":"Synthesis and assembly strategy of electroactive biomaterials and systems for soft tissue engineering applications","authors":"Dong Yang , Yi Hu , Shuai Liu , Wenhui Yang , Xi Ren , Yanbing Li , Feng Xu , Min Gong , Yunlong Zhao , Xiaozhong Qiu , Honghao Hou","doi":"10.1016/j.chempr.2025.102596","DOIUrl":"10.1016/j.chempr.2025.102596","url":null,"abstract":"<div><div>Soft tissue injuries are a common issue affecting human health, and the extent and duration of injuries often constrain the healing process. Electroactive biomaterials have become a key medium for tissue regeneration by modulating cellular behavior, but a systematic evaluation of their potential and challenges is still limited. This review comprehensively explores electroactive biomaterials, focusing on their chemical synthesis, assembly processes, application potential, challenges faced, and future directions. First, this work elaborates on the unique and innovative features of electroactive biomaterials’ chemical synthesis and preparation techniques. Subsequently, the principles of electroactive devices and their interactions with biological tissues are described to optimize tissue repair. Finally, the application prospects of electrical stimulation technology in soft tissue engineering are explored, emphasizing its role in cell and tissue regeneration and its clinical potential. In conclusion, this review provides theoretical and practical insights into the development and application of electroactive biomaterials.</div></div>","PeriodicalId":268,"journal":{"name":"Chem","volume":"11 9","pages":"Article 102596"},"PeriodicalIF":19.6,"publicationDate":"2025-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144088048","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Weaving in polyhedra 多面体编织

IF 19.6 1区化学

Chem Pub Date : 2025-09-11 DOI: 10.1016/j.chempr.2025.102748

Raorao Yang , Liang Zhang

引用次数: 0