Live bacterial chemistry in biomedicine

IF 19.1 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Chem Pub Date : 2025-04-10 DOI:10.1016/j.chempr.2025.102436

Senfeng Zhao , Qian Chen , Qimanguli Saiding , Soohwan An , Zhuoming Zhou , Na Kong , Yujing J. Heng , Reza Abdi , Wei Tao

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Abstract

Live bacteria-based living materials have gained unprecedented attention in the biomedical landscape due to their natural host compatibility and unique dynamic accommodation. In recent decades, the strategic application of live bacteria has yielded revolutionary biomedical outcomes that standardized methods cannot achieve. However, misusing live bacteria may lead to infections, toxicity, or even biochemical dangers for patients. Fortunately, bacteria’s nature as single-celled organisms with relatively well-defined chemical compositions is advantageous. Leveraging our deep understanding of live bacterial chemistry and using chemical tools for management allows us to customize live bacterial behaviors and functions on demand. In this perspective, we will summarize the programmable chemical sites on live bacteria and the potential physical, chemical, or biological functions achievable through chemical engineering. We will focus on chemical approaches to live bacteria-based biomedicine to discuss and highlight how a more defined application of engineered live bacteria concepts could accelerate future clinical transformation.

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生物医学中的活细菌化学

以细菌为基础的活性材料由于其天然的宿主相容性和独特的动态调节，在生物医学领域受到了前所未有的关注。近几十年来，活细菌的战略性应用已经产生了标准化方法无法实现的革命性生物医学成果。然而，误用活菌可能导致患者感染、中毒甚至生化危险。幸运的是，细菌作为单细胞生物，具有相对明确的化学成分，这是有利的。利用我们对活细菌化学的深刻理解和使用化学工具进行管理，使我们能够根据需要定制活细菌的行为和功能。从这个角度来看，我们将总结活细菌的可编程化学位点以及通过化学工程可以实现的潜在物理，化学或生物功能。我们将重点讨论基于活细菌的生物医学的化学方法，并强调如何更明确地应用工程活细菌概念来加速未来的临床转变。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Chem Environmental Science-Environmental Chemistry

CiteScore

32.40

自引率

1.30%

发文量

281

期刊介绍： Chem, affiliated with Cell as its sister journal, serves as a platform for groundbreaking research and illustrates how fundamental inquiries in chemistry and its related fields can contribute to addressing future global challenges. It was established in 2016, and is currently edited by Robert Eagling.