Aquatic Toxicology最新文献

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Interactions between micro(nano)plastics and natural organic matter: implications for toxicity mitigation in aquatic species 微(纳米)塑料与天然有机物之间的相互作用:对水生物种毒性缓解的影响
IF 4.3 2区 环境科学与生态学
Aquatic Toxicology Pub Date : 2025-08-14 DOI: 10.1016/j.aquatox.2025.107541
Naima Hamid , Marriya Sultan , Muhammad Junaid , Stuart Cairns , Iain Robertson , Houda Javed , De-Sheng Pei
{"title":"Interactions between micro(nano)plastics and natural organic matter: implications for toxicity mitigation in aquatic species","authors":"Naima Hamid ,&nbsp;Marriya Sultan ,&nbsp;Muhammad Junaid ,&nbsp;Stuart Cairns ,&nbsp;Iain Robertson ,&nbsp;Houda Javed ,&nbsp;De-Sheng Pei","doi":"10.1016/j.aquatox.2025.107541","DOIUrl":"10.1016/j.aquatox.2025.107541","url":null,"abstract":"<div><div>Plastics have significantly contributed to modern conveniences owing to their ease of use, stability, and adaptability. However, the fragmentation of plastics into microplastics (MPs) and nanoplastics (NPs) poses significant environmental risks. These micro(nano)plastics (MNPs) can adsorb various pollutants and pathogens, potentially posing significant ecological risks. This review critically examines the natural organic matter (NOM) in mitigating the toxicity of MNPs in both marine and freshwater species. Evidence suggests that NOM facilitates the formation of an eco-corona (EC) on MNPs, thereby reducing toxicity. Reduced toxicity attributed to EC formation has been observed in various freshwater species, such as <em>Danio rerio</em> and <em>Daphnia magna</em>, as well as marine species, including sea urchins, European sea bass, and marine algae. The presence of natural organic matter (NOM), particularly fulvic acid (FA) and humic acid (HA), significantly mitigates the toxic effects of MNPs, with HA exhibiting a strong protective effect. The interactions between MNPs and NOM, including the formation of the EC, which encompasses a protein corona component, are pivotal in understanding toxicity mitigation in aquatic environments. This review highlights the need for further research to elucidate the interactions between MNPs and NOM, and their role in mitigating toxicity across marine and freshwater ecosystems.</div></div>","PeriodicalId":248,"journal":{"name":"Aquatic Toxicology","volume":"287 ","pages":"Article 107541"},"PeriodicalIF":4.3,"publicationDate":"2025-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144860404","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Unravelling the role of environmentally realistic concentrations of titanium dioxide nanoparticles in altering gametogenesis and gonadal health of female Pacific oysters (Magallana gigas): a histopathological approach 揭示二氧化钛纳米颗粒在改变雌性太平洋牡蛎配子体发生和性腺健康中的环境现实浓度的作用:一种组织病理学方法
IF 4.3 2区 环境科学与生态学
Aquatic Toxicology Pub Date : 2025-08-13 DOI: 10.1016/j.aquatox.2025.107539
F. Fernández-García , M. Martins , E. Raymond , A. Carvalhais , I.B. Oliveira , J.F. Asturiano , M. Pacheco , C. Mieiro
{"title":"Unravelling the role of environmentally realistic concentrations of titanium dioxide nanoparticles in altering gametogenesis and gonadal health of female Pacific oysters (Magallana gigas): a histopathological approach","authors":"F. Fernández-García ,&nbsp;M. Martins ,&nbsp;E. Raymond ,&nbsp;A. Carvalhais ,&nbsp;I.B. Oliveira ,&nbsp;J.F. Asturiano ,&nbsp;M. Pacheco ,&nbsp;C. Mieiro","doi":"10.1016/j.aquatox.2025.107539","DOIUrl":"10.1016/j.aquatox.2025.107539","url":null,"abstract":"<div><div>Titanium dioxide nanoparticles (TiO<sub>2</sub> NPs) raise environmental concerns due to their potential adverse effects on marine bivalves. However, research on females, particularly their gonad quality and reproduction, remains limited. Despite the availability of numerous health status biomarkers, histopathological analysis remains crucial for assessing toxicological effects. This study aimed to shed light on the potential reprotoxicity of environmentally realistic concentrations of TiO<sub>2</sub> NPs during gametogenesis in female <em>Magallana gigas</em>. Oysters were exposed to waterborne 10 and 100 μg/L of TiO<sub>2</sub> NPs for 3 and 7 days. Thereafter, females were identified, and the gonadal health status was assessed through qualitative and quantitative histology alongside titanium bioaccumulation evaluation. Partial indices for interlobular and intralobular alterations were applied for the first time to the gonad, improving the understanding of histopathological alterations caused by TiO<sub>2</sub> NPs. Our results indicated that the severity of histopathological alterations was concentration and time-dependent, even though no bioaccumulation was detected. We observed an acceleration of gametogenic stage development and disturbances in sex determination. This study provides tools to assess TiO2 NPs’ impacts on bivalve populations and ecosystem balance, especially in highly touristic marine areas.</div></div>","PeriodicalId":248,"journal":{"name":"Aquatic Toxicology","volume":"287 ","pages":"Article 107539"},"PeriodicalIF":4.3,"publicationDate":"2025-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144880119","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Enhanced toxicity of bisphenol F compared to its predecessor bisphenol A in rainbow trout (Oncorhynchus mykiss) during a six-week feeding trial 在为期六周的虹鳟鱼(Oncorhynchus mykiss)饲养试验中,双酚F与双酚A相比毒性增强
IF 4.3 2区 环境科学与生态学
Aquatic Toxicology Pub Date : 2025-08-12 DOI: 10.1016/j.aquatox.2025.107540
Vendula Stoklasova , Premysl Mikula , Aneta Hollerova , Petr Marsalek , Nikola Peskova , Ales Franc , Lucie Sedlackova , Frantisek Tichy , Eva Postulkova , Jan Mares , Zdenka Svobodova , Jana Blahova
{"title":"Enhanced toxicity of bisphenol F compared to its predecessor bisphenol A in rainbow trout (Oncorhynchus mykiss) during a six-week feeding trial","authors":"Vendula Stoklasova ,&nbsp;Premysl Mikula ,&nbsp;Aneta Hollerova ,&nbsp;Petr Marsalek ,&nbsp;Nikola Peskova ,&nbsp;Ales Franc ,&nbsp;Lucie Sedlackova ,&nbsp;Frantisek Tichy ,&nbsp;Eva Postulkova ,&nbsp;Jan Mares ,&nbsp;Zdenka Svobodova ,&nbsp;Jana Blahova","doi":"10.1016/j.aquatox.2025.107540","DOIUrl":"10.1016/j.aquatox.2025.107540","url":null,"abstract":"<div><div>This study aimed to assess the toxicity of bisphenol A (BPA) and bisphenol F (BPF) in rainbow trout following six weeks of dietary exposure. Fish were exposed to BPA, BPF, or their combination at nominal concentrations of 10 and 1000 µg/kg (i.e., BPA<sub>low</sub>, BPA<sub>high</sub>, BPF<sub>low</sub>, BPF<sub>high</sub>, BPA+BPF<sub>low</sub>). Haematological analysis revealed a significant reduction (<em>p</em> &lt; 0.05) in leukocytes and lymphocytes, but only in the BPF<sub>high</sub> group. Plasma biochemical markers showed significant increases (<em>p</em> &lt; 0.05) in creatinine in BPA<sub>low</sub> and elevated amylase activity in both BPF groups. Surprisingly, markers of endocrine disruption, such as vitellogenin and thyroxine, were significantly elevated (<em>p</em> &lt; 0.05) only in BPF<sub>high</sub> and BPA+BPF<sub>low</sub>, despite no pathological changes being observed in the gonads. Oxidative stress markers were significantly affected, with increased catalase activity (<em>p</em> &lt; 0.05) in the liver, kidney, and gill across all groups. Additionally, plasma DNA damage was significantly (<em>p</em> &lt; 0.05) reduced in BPA<sub>low</sub> and BPF<sub>high</sub>. In contrast, significant elevations (<em>p</em> &lt; 0.05) of ceruloplasmin and ferric reducing/antioxidant power were observed in the BPA+BPF<sub>low</sub> and both BPF groups, respectively. Histological examination revealed liver congestion and dystrophy in both BPA groups, hyaline droplet degeneration in the tubular epithelial cells of the caudal kidney across all exposed groups, and deformation of gill filaments in BPA+BPF<sub>low</sub> and both BPA groups. Our findings underscore that the increasing use of BPA analogues may pose a greater risk than the original compound in certain contexts, emphasizing the need for further studies to understand the long-term effects of bisphenol analogues, particularly at environmentally relevant concentrations and in mixtures.</div></div>","PeriodicalId":248,"journal":{"name":"Aquatic Toxicology","volume":"287 ","pages":"Article 107540"},"PeriodicalIF":4.3,"publicationDate":"2025-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144865533","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
BPA disrupts crustacean reproduction: Tissue-specific accumulation, oxidative stress, and gene dysregulation in Macrobrachium nipponense BPA破坏甲壳类动物繁殖:日本沼虾的组织特异性积累、氧化应激和基因失调
IF 4.3 2区 环境科学与生态学
Aquatic Toxicology Pub Date : 2025-08-11 DOI: 10.1016/j.aquatox.2025.107538
Jintao Liu , Ruijie Zhu , Shuhao Wang , Xinyuan Dai , Anran Zou , Fengjuan Jiang , Shengming Sun , Jiangtao Ou , Weihong Zhao
{"title":"BPA disrupts crustacean reproduction: Tissue-specific accumulation, oxidative stress, and gene dysregulation in Macrobrachium nipponense","authors":"Jintao Liu ,&nbsp;Ruijie Zhu ,&nbsp;Shuhao Wang ,&nbsp;Xinyuan Dai ,&nbsp;Anran Zou ,&nbsp;Fengjuan Jiang ,&nbsp;Shengming Sun ,&nbsp;Jiangtao Ou ,&nbsp;Weihong Zhao","doi":"10.1016/j.aquatox.2025.107538","DOIUrl":"10.1016/j.aquatox.2025.107538","url":null,"abstract":"<div><div>Bisphenol A (BPA), a pervasive environmental endocrine disruptor, increasingly threatens aquatic ecosystems due to its reproductive toxicity. This study investigates how BPA disrupts ovarian development in <em>Macrobrachium nipponense</em> - by analyzing its tissue-specific bioaccumulation (ovaries, hepatopancreas, fertilized eggs), antioxidant responses, and developmental gene regulation. Experimental results demonstrated that after 10-day exposure to 10, 100, and 1000 μg/L BPA, significant BPA accumulation was observed in both ovaries and hepatopancreas, while fertilized eggs showed notable accumulation only at the highest concentration (1000 μg/L) (<em>P</em> &lt; 0.05). The ovarian glutathione peroxidase (GSH-Px) activity displayed a concentration-dependent increase, contrasting with the inverse pattern observed in fertilized eggs. Gene expression analysis revealed that cytochrome P450 49A1 (<em>CYP49a1</em>) in both ovaries and hepatopancreas reached peak levels at the highest BPA concentration, whereas cathepsin D (<em>CTSD</em>) and catalase (<em>CAT</em>) expression peaked at the intermediate concentration (100 μg/L) in both tissues (<em>P</em> &lt; 0.05), while female sterile homeotic (<em>fsh</em>) in ovaries remained steady but significantly decreased in hepatopancreas upon BPA exposure (<em>P</em> &lt; 0.05). These results provide preliminary evidence that BPA may disrupt ovarian development in <em>M. nipponense</em> through interfering with antioxidant systems and altering the expression of key developmental genes, highlighting its potential endocrine-disrupting effects in this commercially important crustacean species.</div></div>","PeriodicalId":248,"journal":{"name":"Aquatic Toxicology","volume":"287 ","pages":"Article 107538"},"PeriodicalIF":4.3,"publicationDate":"2025-08-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144830276","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Assessing the solubility, chemical stability and ecotoxicology of an emerging non-halogenated flame retardant, melamine cyanurate, against a prevalent halogenated congener, tetrabromophthalic anhydride 评估一种新兴的非卤化阻燃剂三聚氰胺氰脲酸酯与一种普遍存在的卤化同系物四溴苯酐的溶解度、化学稳定性和生态毒理学
IF 4.3 2区 环境科学与生态学
Aquatic Toxicology Pub Date : 2025-08-10 DOI: 10.1016/j.aquatox.2025.107537
N. Masud , P. Hansal , B.D. Ward , J. Cable
{"title":"Assessing the solubility, chemical stability and ecotoxicology of an emerging non-halogenated flame retardant, melamine cyanurate, against a prevalent halogenated congener, tetrabromophthalic anhydride","authors":"N. Masud ,&nbsp;P. Hansal ,&nbsp;B.D. Ward ,&nbsp;J. Cable","doi":"10.1016/j.aquatox.2025.107537","DOIUrl":"10.1016/j.aquatox.2025.107537","url":null,"abstract":"<div><div>Concerns over plastic-associated chemical toxicity are increasing amid the plastic pollution crisis. Halogenated flame retardants, though effective in plastic development, are being phased out due to toxicity, while nitrogen-based alternatives, such as melamine cyanurate (MC), are considered more chemically stable and less toxic. Here, we assess the solubility and chemical stability of MC in freshwater using various solvents and evaluate degradation after UV exposure. Additionally, we compare the acute and chronic aquatic toxicity of MC to the more widespread halogenated flame retardant tetrabromophthalic anhydride (TBA) using the <em>Daphnia magna</em> invertebrate model. Toxicity of a common solvent, dimethyl sulfoxide (DMSO), was also assessed. MC was insoluble in 16 of 18 tested solvents, with solubility only seen in a strong acid and base. UV exposure for 72 h within freshwater media indicated minimal degradation, classifying MC as a highly stable compound. Acute toxicity tests at 1–20 mg/L showed no significant difference in EC<sub>50</sub> values between TBA (0.16 - 11.46 mg/L) and MC (5.91 - 13.23 mg/L). Chronic toxicity tests at 0.5, 5, and 15 mg/L yielded NOEC values of ≤5 mg/L for TBA and &lt;5 mg/L for MC. At 15 mg/L, chronic exposure to TBA, MC, and DMSO resulted in 100% mortality in <em>D. magna</em>. These findings challenge the assumption that DMSO is a low-toxicity solvent in aquatic testing. Overall, the study highlights the difficulty in assessing the toxicity of highly stable flame retardants like MC, while indicating that they may exhibit similar aquatic toxicity as halogenated congeners.</div></div>","PeriodicalId":248,"journal":{"name":"Aquatic Toxicology","volume":"287 ","pages":"Article 107537"},"PeriodicalIF":4.3,"publicationDate":"2025-08-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144830277","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Intestinal microbiota and metabolomics reveal the intestinal damage caused by imidacloprid in loaches (Misgurnus anguillicaudatus) 肠道菌群和代谢组学揭示吡虫啉对泥鳅肠道的损害
IF 4.3 2区 环境科学与生态学
Aquatic Toxicology Pub Date : 2025-08-10 DOI: 10.1016/j.aquatox.2025.107533
Yingbing Su , Yongxi Huang , Pupu Yan , Jiali Liu , Man Liu , Jun Zhu , Yinuo Gong , Haishan Chen , Liwei Guo
{"title":"Intestinal microbiota and metabolomics reveal the intestinal damage caused by imidacloprid in loaches (Misgurnus anguillicaudatus)","authors":"Yingbing Su ,&nbsp;Yongxi Huang ,&nbsp;Pupu Yan ,&nbsp;Jiali Liu ,&nbsp;Man Liu ,&nbsp;Jun Zhu ,&nbsp;Yinuo Gong ,&nbsp;Haishan Chen ,&nbsp;Liwei Guo","doi":"10.1016/j.aquatox.2025.107533","DOIUrl":"10.1016/j.aquatox.2025.107533","url":null,"abstract":"<div><div>Aim of this research was to assess the presence of imidacloprid residues in aquatic environments and their impact on the intestinal health of loaches. The concentrations of imidacloprid examined were 146 μg/L, 73 μg/L, 36.5 μg/L, 18.25 μg/L, 9.125 μg/L, and 4.5625 μg/L. Following a 28-day exposure period, alterations were observed in the intestinal barrier, inflammatory damage, antioxidant levels, intestinal microbiota, metabolite groups, and target genes of the loach. The exposure to imidacloprid caused damage to the intestinal barrier, infiltration of inflammatory cells, and downregulation of Occludin and ZO-1 protein expression in the intestinal tissue of loaches, while concurrently inducing oxidative stress and inflammatory damage. Furthermore, imidacloprid was found to diminish the diversity of gut microbiota while increasing the abundance of harmful bacterial taxa, specifically <em>Proteobacteria</em> and <em>Aeromonas</em>, thereby disrupting microbiota functionality. Metabolomic analysis revealed a significant increase in the number of differentially expressed genes associated with both upregulated and downregulated metabolites following exposure to imidacloprid, with these metabolites demonstrating dose-dependent effects. Additionally, interactions between metabolites and imidacloprid were identified through the regulation of CA, HSP90, and HSP60. This study highlights the detrimental effects of imidacloprid on loaches even at non-lethal concentrations.</div></div>","PeriodicalId":248,"journal":{"name":"Aquatic Toxicology","volume":"287 ","pages":"Article 107533"},"PeriodicalIF":4.3,"publicationDate":"2025-08-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144879708","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Neurodevelopmental toxicity of black carbon in zebrafish: behavioral and metabolomic insights 黑碳在斑马鱼中的神经发育毒性:行为和代谢组学的见解
IF 4.3 2区 环境科学与生态学
Aquatic Toxicology Pub Date : 2025-08-09 DOI: 10.1016/j.aquatox.2025.107536
Fanrui Yu , Yanhua Liu , Manting Li , Yaqian Gao , Leilei Lu , Jianqiu Chen , Ruixin Guo
{"title":"Neurodevelopmental toxicity of black carbon in zebrafish: behavioral and metabolomic insights","authors":"Fanrui Yu ,&nbsp;Yanhua Liu ,&nbsp;Manting Li ,&nbsp;Yaqian Gao ,&nbsp;Leilei Lu ,&nbsp;Jianqiu Chen ,&nbsp;Ruixin Guo","doi":"10.1016/j.aquatox.2025.107536","DOIUrl":"10.1016/j.aquatox.2025.107536","url":null,"abstract":"<div><div>Black carbon (BC), a combustion-derived particulate pollutant, is increasingly detected in aquatic ecosystems. While its respiratory and cardiovascular effects are well documented, its neurotoxicity in aquatic organisms remains poorly understood. In this study, zebrafish (Danio rerio) embryos were exposed to environmentally relevant BC concentrations (0, 0.05, 0.5, and 5 mg/L) for 168 h. BC induced dose-dependent developmental toxicity, manifested as reduced body length and eye size, elevated heart rate, and morphological abnormalities. Behavioral assays revealed deficits in locomotion and phototaxis. Neurochemical analysis revealed concentration-dependent reductions in serotonin (5-HT) and gamma-aminobutyric acid (GABA). Transgenic imaging indicated impaired neuronal and glial development in the embryos. Untargeted metabolomics revealed disruptions in multiple pathways, particularly glycine, serine, threonine, taurine, and hypotaurine metabolism, which correlated with behavioral changes. These findings provide the first integrative evidence that BC neurotoxicity involves both structural damage to the developing nervous system and broad metabolic disturbances. Our results highlight BC as a previously underrecognized neurotoxicant of ecological concern.</div></div>","PeriodicalId":248,"journal":{"name":"Aquatic Toxicology","volume":"287 ","pages":"Article 107536"},"PeriodicalIF":4.3,"publicationDate":"2025-08-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144852388","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The exploration of chronic combined toxic mechanisms of environmental PFOA and polyethylene micro/nanoplastics on adult zebrafish (Danio rerio), using aquatic microcosm systems 环境PFOA和聚乙烯微/纳米塑料对成年斑马鱼(Danio rerio)慢性联合毒性机制的探讨
IF 4.3 2区 环境科学与生态学
Aquatic Toxicology Pub Date : 2025-08-08 DOI: 10.1016/j.aquatox.2025.107534
Wei Wu , Ruixuan Li , Zhiqiang Zhang , Gang Liu , Yingxue Sun , Chun Wang
{"title":"The exploration of chronic combined toxic mechanisms of environmental PFOA and polyethylene micro/nanoplastics on adult zebrafish (Danio rerio), using aquatic microcosm systems","authors":"Wei Wu ,&nbsp;Ruixuan Li ,&nbsp;Zhiqiang Zhang ,&nbsp;Gang Liu ,&nbsp;Yingxue Sun ,&nbsp;Chun Wang","doi":"10.1016/j.aquatox.2025.107534","DOIUrl":"10.1016/j.aquatox.2025.107534","url":null,"abstract":"<div><div>Understanding the extent of environmental damage caused by plastic particles and emerging pollutants in aquaculture, particularly within recirculating aquaculture systems (RAS) that rely on advanced water treatment technologies, is constrained by insufficient knowledge regarding the chronic combined toxicity of these contaminants on representative fish species under real environmental conditions. This study investigates the combined toxic effects of polyethylene microplastics (PE-MPs), polyethylene nanoplastics (PE-NPs), and perfluorooctanoic acid (PFOA) on adult zebrafish at environmentally relevant concentrations in aquatic microcosm systems (AMS) simulating RAS exposure scenarios. The combined exposure to PE-MPs, PE-NPs, and PFOA exhibited time-dependent toxicity patterns: synergistic effects on zebrafish gills and liver after 7 days, followed by antagonistic interactions after 28 days of chronic exposure. MPs induced higher intestinal toxicity than NPs through mechanical damage and lipid peroxidation mechanisms. Both individual and combined exposures caused structural alterations in zebrafish intestines, with MPs provoking more severe villi atrophy and goblet cell reduction compared to NPs, while co-exposure exacerbated these pathological changes. Notably, PFOA triggered acetylcholine upregulation in intestinal and hepatic tissues, revealing stronger neurotoxic impacts than those observed in gill systems. Additionally, the co-exposure to MPs + PFOA and NPs + PFOA led to an increased abundance of Fusobacterium in zebrafish intestines, thereby enhancing their susceptibility to pathogenic infections. These findings highlight the complex temporal dynamics and tissue-specific risks of microplastic-PFOA interactions in closed aquaculture environments, providing critical insights for optimizing RAS water management strategies against emerging contaminant mixtures.</div></div>","PeriodicalId":248,"journal":{"name":"Aquatic Toxicology","volume":"287 ","pages":"Article 107534"},"PeriodicalIF":4.3,"publicationDate":"2025-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144828225","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effects of neonicotinoid and diamide-contaminated agricultural runoff on Lymnaea stagnalis: Insights into stress, neurotoxicity, and antioxidant response 新烟碱类和二胺污染的农业径流对停滞林蝇的影响:应激、神经毒性和抗氧化反应的见解
IF 4.3 2区 环境科学与生态学
Aquatic Toxicology Pub Date : 2025-08-08 DOI: 10.1016/j.aquatox.2025.107535
Veronica Rivi , Grace Pele , Kate Yakubets , Anuradha Batabyal , Roberto Dominici , Johanna Maria Catharina Blom , Fabio Tascedda , Cristina Benatti , Ken Lukowiak
{"title":"Effects of neonicotinoid and diamide-contaminated agricultural runoff on Lymnaea stagnalis: Insights into stress, neurotoxicity, and antioxidant response","authors":"Veronica Rivi ,&nbsp;Grace Pele ,&nbsp;Kate Yakubets ,&nbsp;Anuradha Batabyal ,&nbsp;Roberto Dominici ,&nbsp;Johanna Maria Catharina Blom ,&nbsp;Fabio Tascedda ,&nbsp;Cristina Benatti ,&nbsp;Ken Lukowiak","doi":"10.1016/j.aquatox.2025.107535","DOIUrl":"10.1016/j.aquatox.2025.107535","url":null,"abstract":"<div><div>Freshwater pollution from agrochemicals poses an increasing threat to aquatic ecosystems. Yet, the sublethal effects of such contaminants on cognition and neural function in non-target invertebrate species remain poorly understood. Using a field-collected source of pesticide-contaminated freshwater (Spirit Creek Pond water, SCW) and two <em>Lymnaea stagnalis</em> strains, one collected directly from Spirit Creek (SC strain) and another inbred laboratory strain (W strain), we address the core questions: (1) what are the transcriptional consequences of SCW exposure? (2) are these effects strain-specific? (3) does SCW impair higher-order configural learning (CL)? (4) and, if so, can cognitive function recover following a 14-day washout period in uncontaminated water? SCW exposure significantly altered the expression levels of stress-response and cholinergic receptors in a strain-dependent manner. In both strains, LymHSP70 and LymSOD1 were significantly upregulated during exposure and downregulated after washout, indicating acute stress with partial transcriptional recovery. In W-strain snails, LymGSR was uniquely and persistently upregulated post-washout, suggesting sustained oxidative imbalance. Moreover, W-strain snails exhibited significant upregulation of cholinergic receptor genes LymnAChR_G and LymnAChR_E during SCW exposure, followed by downregulation after washout, suggesting a reversible but lasting disruption in cholinergic signaling. Behaviorally, CL was abolished in both strains following SCW exposure, with no evidence of cognitive recovery after the washout period. These results demonstrate that exposure to environmentally relevant contaminants induces lasting neurobehavioral impairments and molecular dysregulation in <em>L. stagnalis</em>, with strain-specific differences in susceptibility and recovery. Our findings underscore the need for long-term ecological monitoring of freshwater neurotoxicants and their impacts on invertebrate neural health and cognition.</div></div>","PeriodicalId":248,"journal":{"name":"Aquatic Toxicology","volume":"287 ","pages":"Article 107535"},"PeriodicalIF":4.3,"publicationDate":"2025-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144828006","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Roles of bio-based microplastics in modulating the toxic effects of the herbicide metolachlor on the South American native species Palaemon argentinus: Single and co-exposure effects 生物基微塑料在调节除草剂异甲草胺对南美本土物种阿根廷古鲑的毒性作用中的作用:单一和共同暴露效应
IF 4.3 2区 环境科学与生态学
Aquatic Toxicology Pub Date : 2025-08-06 DOI: 10.1016/j.aquatox.2025.107532
Lidwina Bertrand , Naomi Carolina Yacelga Villavicencio , Guido Noé Rimondino , María Florencia Gonzalez , María Valeria Amé
{"title":"Roles of bio-based microplastics in modulating the toxic effects of the herbicide metolachlor on the South American native species Palaemon argentinus: Single and co-exposure effects","authors":"Lidwina Bertrand ,&nbsp;Naomi Carolina Yacelga Villavicencio ,&nbsp;Guido Noé Rimondino ,&nbsp;María Florencia Gonzalez ,&nbsp;María Valeria Amé","doi":"10.1016/j.aquatox.2025.107532","DOIUrl":"10.1016/j.aquatox.2025.107532","url":null,"abstract":"<div><div>Microplastics (MPs), including those from bio-based plastics (BBPs), are increasingly detected in aquatic ecosystems, raising concerns about their role in modifying pollutant toxicity. This study investigated environmentally relevant concentrations of polylactic acid microplastics (PLA-MPs) on the South American native shrimp <em>Palaemon argentinus</em>, evaluating single and co-exposure scenarios with metolachlor (MET) over a 7-day bioassay. Characterization of PLA-MPs revealed a fragment shape with typical PLA spectroscopic pattern and an elemental composition of &gt;80 % C and ∼15 % O. Both PLA-MPs and MET accumulated in the shrimp, causing oxidative stress, neurotoxicity, and tissue damage. Significant inhibition of acetylcholinesterase in shrimp exposed to PLA-MPs suggests impaired locomotion and behavior, which may affect population dynamics and ecosystem function. The MET adsorption on PLA-MPs was confirmed under tested conditions. The co-exposure increased MET prevalence in the cephalothorax, indicating the role of BBP particles as pesticide transporters in aquatic ecosystems. In addition, calculated bioaccumulation factors suggested a minimal trophic transfer of MET under the tested conditions. The integrated biomarker response revealed co-exposure stress levels intermediate between MET exposure and PLA-MPs treatment, suggesting partial antagonistic interactions. Reduced cytoplasmic MET bioavailability via PLA-MP adsorption was hypothesized as the underlying mechanism. These results indicate complex MP-chemical interactions, with possible antagonistic effects at the biochemical and tissue levels, and highlight the need for further research on the ecotoxicity of BBPs. Greater efforts are needed to elucidate the role of plastic additives in toxicity and the role of MPs in the bioaccumulation processes of pesticides. This would be useful to assess the environmental impact of BBPs and determine their viability as a sustainable alternative to conventional plastics.</div></div>","PeriodicalId":248,"journal":{"name":"Aquatic Toxicology","volume":"287 ","pages":"Article 107532"},"PeriodicalIF":4.3,"publicationDate":"2025-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144810345","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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