Aquatic Toxicology最新文献_第10页

An adverse outcome pathway approach linking retinoid signaling disruption to teratogenicity and population-level outcomes 将视黄醇信号干扰与致畸性和人群结果联系起来的不良结果途径方法。

IF 4.1 2区环境科学与生态学

Aquatic Toxicology Pub Date : 2024-11-05 DOI: 10.1016/j.aquatox.2024.107143

Audrey Phan, Aleksandra Sokolova, Klara Hilscherova

{"title":"An adverse outcome pathway approach linking retinoid signaling disruption to teratogenicity and population-level outcomes","authors":"Audrey Phan, Aleksandra Sokolova, Klara Hilscherova","doi":"10.1016/j.aquatox.2024.107143","DOIUrl":"10.1016/j.aquatox.2024.107143","url":null,"abstract":"<div><div>Recent research efforts in endocrine disruption have focused on evaluating non-EATS (estrogen, androgen, thyroid, and steroidogenesis) pathways. Retinoid signaling disruption is noteworthy because of its teratogenic effects and environmental relevance. However, current environmental risk assessments are limited in their ability to evaluate impacts on individuals and populations. This study characterizes an Adverse Outcome Pathway (AOP) network linking retinoid signaling disruption to teratogenicity and survival in zebrafish. We identified Retinoic Acid Receptor (RAR) overactivation as the molecular initiating event leading to key events including craniofacial (CFM) and tail (TM) malformations, posterior swim bladder (SB) non-inflation, impaired swimming performance, and reduced feeding, ultimately resulting in decreased survival. Our study (1) determines critical sensitivity windows for CFM, posterior SB non-inflation, and TM, (2) provides quantitative measurements for CFM and TM, and (3) defines impacts on higher biological levels including food ingestion, swimming, and survival. Results show that all-trans retinoic acid (ATRA) induces strong teratogenic effects with sensitivity windows between 4 and 48 h post fertilization (hpf) for CFM, TM, and posterior SB non-inflation. TM is the most sensitive indicator, with EC<sub>50</sub> of 0.2 - 0.26 µg/L across exposure windows 4–48, 4–72, 4–96, and 4–120 hpf. Besides inducing known malformations, ATRA impaired posterior SB inflation with EC<sub>50</sub> of 1 - 1.21 µg/L across the same exposure windows. ATRA exposure (1 µg/L) resulted in 50 % food ingestion inhibition at 7 days post fertilization (dpf) and 10 % survival at 14 dpf. This study provides a regulatory-relevant framework linking developmental effects to population outcomes, highlighting ecological risks and needs for improved risk assessments.</div></div>","PeriodicalId":248,"journal":{"name":"Aquatic Toxicology","volume":"277 ","pages":"Article 107143"},"PeriodicalIF":4.1,"publicationDate":"2024-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142646039","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ion-exchange chromatography in the assessment of environmental pollution with chlortetracycline 离子交换色谱法在金霉素环境污染评估中的应用

IF 4.1 2区环境科学与生态学

Aquatic Toxicology Pub Date : 2024-11-02 DOI: 10.1016/j.aquatox.2024.107142

Łukasz Sikorski , Agnieszka Bęś , Elżbieta Karetko-Sikorska , Wojciech Truszkowski , Katarzyna Tomaszewska

{"title":"Ion-exchange chromatography in the assessment of environmental pollution with chlortetracycline","authors":"Łukasz Sikorski , Agnieszka Bęś , Elżbieta Karetko-Sikorska , Wojciech Truszkowski , Katarzyna Tomaszewska","doi":"10.1016/j.aquatox.2024.107142","DOIUrl":"10.1016/j.aquatox.2024.107142","url":null,"abstract":"<div><div>Chemical substances such as drugs pose a threat to the environment. One of the substances recorded in soil and water is chlortetracycline, an antibiotic used in veterinary medicine. Plants exposed to such xenobiotics show changes in the content of biogenic amines. An analytical technique - ion exchange chromatography is used to assess their content. The occurrence of these active compounds is used to determine the degree of environmental pollution with chemical substances. The study aimed to evaluate the toxicity of chlortetracycline (CTC) at concentrations of 0; 0.05; 0.1; 0.2 0.5;1; 2; 3; and 5 mM towards the test organism <em>Lemna minor</em>, and determine the content of biogenic amines in the plant tissues. The content of biogenic amines was analyzed by ion-exchange chromatography with post-column ninhydrin derivatization and photometric detection. The Lemna test proved that increasing concentrations of CTC had a toxic effect on the plants. It was calculated that the Lowest Observed Effects Concentration (LOEC) of CTC at >0.04 mM and >0.05 mM was phytotoxic to L. <em>minor</em> growth and yield. It was determined that the levels of histamine, tyramine, and cadaverine exhibited an increase, reaching 1.04, 1.90, and 3.10 µg g<sup>-1</sup> of tissue at 2.00 mM CTC. Simultaneously, spermine and putrescine increased to 1.21 and 3.89 µg g<sup>-1</sup> of tissue at concentrations of 0.10 and 0.50 mM of the drug. Conversely, the study revealed an over 88 % reduction in spermidine in plants at 5 mM of CTC. Using ion-exchange chromatography, analysis of biogenic amines, particularly spermidine and cadaverine, highlighted these intra-tissue compounds as sensitive biomarkers for water contamination with the tested drug. This research confirmed that the Lemna test is effective for assessing CTC toxicity and that ion-exchange chromatography is useful for evaluating environmental pollution by this antibiotic.</div></div>","PeriodicalId":248,"journal":{"name":"Aquatic Toxicology","volume":"277 ","pages":"Article 107142"},"PeriodicalIF":4.1,"publicationDate":"2024-11-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142586013","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bioaccumulation and biochemical impact of polyethylene terephthalate microplastics in Cipangopaludina chinensis: Tissue-specific analysis and homeostasis disruption 聚对苯二甲酸乙二醇酯微塑料在Cipangopaludina chinensis体内的生物累积和生化影响：组织特异性分析和稳态破坏。

IF 4.1 2区环境科学与生态学

Aquatic Toxicology Pub Date : 2024-11-02 DOI: 10.1016/j.aquatox.2024.107144

Lanjin Fang , Shuangshuang Wang , Xingbin Sun , Kejing Wang

{"title":"Bioaccumulation and biochemical impact of polyethylene terephthalate microplastics in Cipangopaludina chinensis: Tissue-specific analysis and homeostasis disruption","authors":"Lanjin Fang , Shuangshuang Wang , Xingbin Sun , Kejing Wang","doi":"10.1016/j.aquatox.2024.107144","DOIUrl":"10.1016/j.aquatox.2024.107144","url":null,"abstract":"<div><div>Microplastics are a novel pollutant that adversely affect freshwater benthic organisms. However, few studies have investigated the mechanism underlying the bioaccumulation and the toxicity of microplastics. In this study, microplastics bioaccumulation of wild <em>Cipangopaludina chinensis</em> in the Songhua River were utilized, and a 28-day aquatic toxicity test was performed to determine the effects of exposure to polyethylene terephthalate (PET), the bioaccumulation of PET, and changes in multiple biomarkers in the muscle, gill, and kidney tissues. The concentration pattern of microplastics was as follows: kidney tissue > muscle tissue > gill tissue. Microplastic ingestion caused AChE inhibition led to significant increases in redox and energy metabolism indicators. Furthermore, the IBR analysis presented a \"response-resistance-breakdown\" process, indicating that <em>Cipangopaludina chinensis</em> possessed resistance with time (D14 and D21) and concentration (0.10 mg/L and 1.00 mg/L) thresholds. Tissue sensitivity to microplastics was ranked as gill > muscle > kidney, which was the opposite order of microplastic accumulation. These findings implied that less sensitive tissues stored a larger amount of pollutants, suggesting a reduction in tissue sensitivity to microplastics with higher microplastic occurrence rates. This study provides new insights into biological resistance to pollutant stress, warranting further investigation into the underlying mechanisms.</div></div>","PeriodicalId":248,"journal":{"name":"Aquatic Toxicology","volume":"277 ","pages":"Article 107144"},"PeriodicalIF":4.1,"publicationDate":"2024-11-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142613364","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Elucidation of molecular mechanisms involved in tadpole toxicity employing QSTR and q-RASAR approach 利用 QSTR 和 q-RASAR 方法阐明蝌蚪毒性的分子机制。

IF 4.1 2区环境科学与生态学

Aquatic Toxicology Pub Date : 2024-11-02 DOI: 10.1016/j.aquatox.2024.107136

Kabiruddin Khan , Gopala Krishna Jillella , Agnieszka Gajewicz-Skretna

{"title":"Elucidation of molecular mechanisms involved in tadpole toxicity employing QSTR and q-RASAR approach","authors":"Kabiruddin Khan , Gopala Krishna Jillella , Agnieszka Gajewicz-Skretna","doi":"10.1016/j.aquatox.2024.107136","DOIUrl":"10.1016/j.aquatox.2024.107136","url":null,"abstract":"<div><div>Tadpoles, as early developmental stages of frogs, are vital indicators of toxicity and environmental health in ecosystems exposed to harmful organic compounds from industrial and runoff sources. Evaluating each compound individually is challenging, necessitating the use of <em>in silico</em> methods like Quantitative Structure Toxicity-Relationship (QSTR) and Quantitative Read-Across Structure-Activity Relationship (q-RASAR). Utilizing the comprehensive US EPA's ECOTOX database, which includes acute LC<sub>50</sub> toxicity and chronic endpoints, we extracted crucial data such as study types, exposure routes, and chemical categories. Regression-based QSTR and q-RASAR models were developed from this dataset, emphasizing key chemical descriptors. Lipophilicity and unsaturation were significant for predicting acute toxicity, while electrophilicity, nucleophilicity, and molecular branching were crucial for chronic toxicity predictions. Additionally, q-RASAR models integrated with the \"intelligent consensus\" algorithm were employed to enhance predictive accuracy. The performance of these models was rigorously compared across various approaches. These refined models not only predict the toxicity of untested compounds but also reveal underlying structural influences. Validation through comparison with existing literature affirmed the relevance and robustness of our approach in ecotoxicology.</div></div>","PeriodicalId":248,"journal":{"name":"Aquatic Toxicology","volume":"277 ","pages":"Article 107136"},"PeriodicalIF":4.1,"publicationDate":"2024-11-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142637980","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Enhancing eco-sensing in aquatic environments: Fish jumping behavior automatic recognition using YOLOv5 增强水生环境中的生态感应：使用 YOLOv5 自动识别鱼类跳跃行为。

IF 4.1 2区环境科学与生态学

Aquatic Toxicology Pub Date : 2024-11-01 DOI: 10.1016/j.aquatox.2024.107137

Kaibang Xiao , Ronghui Li , Senhai Lin , Xianyu Huang

{"title":"Enhancing eco-sensing in aquatic environments: Fish jumping behavior automatic recognition using YOLOv5","authors":"Kaibang Xiao , Ronghui Li , Senhai Lin , Xianyu Huang","doi":"10.1016/j.aquatox.2024.107137","DOIUrl":"10.1016/j.aquatox.2024.107137","url":null,"abstract":"<div><div>Contemporary research on ichthyological behavior predominantly investigates underwater environments. However, the intricate nature of aquatic ecosystems often hampers subaqueous observations of fish behavior due to interference. Transitioning the observational perspective from subaqueous to supra-aquatic enables a more direct assessment of fish physiology and habitat conditions. In this study, we utilized the YOLOv5 convolutional neural network target detection model to develop a fish jumping behavior (FJB) recognition model. A dataset comprising 877 images of fish jumping, captured via a camera in a reservoir, was assembled for model training and validation. After training and validating the model, its recognition accuracy was further tested in real aquatic environments. The results show that YOLOv5 outperforms YOLOv7, YOLOv8, and YOLOv9 in detecting splashes. Post 50 training epochs, YOLOv5 achieved over 97 % precision and recall in the validation set, with an F1 score exceeding 0.9. Furthermore, an enhanced YOLOv5-SN model was devised by integrating specific rules related to ripple size variation and duration, attributable to fish jumping. This modification significantly mitigates noise interference in the detection process. The model's robustness against weather variations ensures reliable detection of fish jumping behavior under diverse meteorological conditions, including rain, cloudiness, and sunshine. Different meteorological elements exert varying effects on fish jumping behavior. The research results can lay the foundation for intelligent perception in aquatic ecology assessment and aquaculture.</div></div>","PeriodicalId":248,"journal":{"name":"Aquatic Toxicology","volume":"277 ","pages":"Article 107137"},"PeriodicalIF":4.1,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142613367","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Chronic toxic effects of chloroxylenol exposure on Rana chensinensis: Insights from endochondral ossfication 氯氧苯酚暴露对滇金丝猴的慢性毒性影响：软骨内骨化的启示

IF 4.1 2区环境科学与生态学

Aquatic Toxicology Pub Date : 2024-10-30 DOI: 10.1016/j.aquatox.2024.107140

Yue Zhang , Zhaoyang Jiang , Xinyi Li

引用次数: 0

Ocean acidification aggravates the toxicity of deltamethrin in Haliotis discus hannai: Insights from immune response, histopathology and physiological responses 海洋酸化加剧了溴氰菊酯对汉娜鱼（Haliotis discus hannai）的毒性：免疫反应、组织病理学和生理反应的启示。

IF 4.1 2区环境科学与生态学

Aquatic Toxicology Pub Date : 2024-10-29 DOI: 10.1016/j.aquatox.2024.107139

Xiaojing Lv , Qinyou Deng , Lizhu Chen , Xin Wang , Yijing Han , Guiqing Wu , Yongliang Liu , Haiyue Sun , Xuan Li , Jinxia He , Xiangquan Liu , Dinglong Yang , Jianmin Zhao

{"title":"Ocean acidification aggravates the toxicity of deltamethrin in Haliotis discus hannai: Insights from immune response, histopathology and physiological responses","authors":"Xiaojing Lv , Qinyou Deng , Lizhu Chen , Xin Wang , Yijing Han , Guiqing Wu , Yongliang Liu , Haiyue Sun , Xuan Li , Jinxia He , Xiangquan Liu , Dinglong Yang , Jianmin Zhao","doi":"10.1016/j.aquatox.2024.107139","DOIUrl":"10.1016/j.aquatox.2024.107139","url":null,"abstract":"<div><div>Ocean acidification (OA) and other environmental factors can collectively affect marine organisms. Deltamethrin (DM), a type II pyrethroid insecticide, has been widely detected in coastal and estuarine areas, while little attention has been given to the combined effects of DM and OA. In this study, <em>Haliotis discus hannai</em> was exposed to three pH levels (8.1, 7.7 and 7.4) and three DM nominal concentrations (0 μg/L, 0.6 μg/L and 6 μg/L) for 14 and 28 days. The results indicated that experimental acidification and/or DM exposure led to impaired immune function and pathological damage. Additionally, acidified conditions and DM exposure induced oxidative stress, and gills are more sensitive than digestive glands. With increasing <em>p</em>CO<sub>2</sub> and DM nominal concentrations, superoxide dismutase (SOD) activity decreased, whereas catalase (CAT) and glutathione S-transferase (GST) activities increased in the gills. Moreover, the expression levels of Toll-like receptor (TLR) pathway-related genes were upregulated after exposure. Integrated biomarker response (IBR) analysis proved that acidified conditions and/or DM detrimentally affected the overall fitness of <em>H. discus hannai</em>, and co-exposure to experimental acidification and DM was the most stressful condition. This study emphasizes the necessity of incorporating OA in future pollutant environmental assessments to better elucidate the risks of environmental disturbance.</div></div>","PeriodicalId":248,"journal":{"name":"Aquatic Toxicology","volume":"277 ","pages":"Article 107139"},"PeriodicalIF":4.1,"publicationDate":"2024-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142602146","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Appraisal of a synthetic preservative, Quaternium – 15, effect on three model organisms: new insight on environmental risks 评估合成防腐剂 Quaternium - 15 对三种模式生物的影响：关于环境风险的新见解。

IF 4.1 2区环境科学与生态学

Aquatic Toxicology Pub Date : 2024-10-29 DOI: 10.1016/j.aquatox.2024.107138

Giorgia Zicarelli , Federica Impellitteri , Caterina Faggio , Jana Blahova , Barbora Riesova , Renata Hesova , Pavla Lakdawala

{"title":"Appraisal of a synthetic preservative, Quaternium – 15, effect on three model organisms: new insight on environmental risks","authors":"Giorgia Zicarelli , Federica Impellitteri , Caterina Faggio , Jana Blahova , Barbora Riesova , Renata Hesova , Pavla Lakdawala","doi":"10.1016/j.aquatox.2024.107138","DOIUrl":"10.1016/j.aquatox.2024.107138","url":null,"abstract":"<div><div>After the COVID-19 pandemic, the use of quaternary ammonium compounds increased exponentially due to their efficacy as antimicrobials, stabilizers and disinfectants. Among these, Quaternium-15 is a preservative used in the formulation of a variety of personal care products. The increased use of this substance and the resulting persistence in wastewater treatment systems, which are unable to completely remove the Quaternium-15 from the water, is of increasing environmental concern. Using embryotoxicity analyses, this study aimed to investigate the effects of exposure to Quaternium-15 on non-target species and the resulting risks to the environment. Embryotoxicity endpoints such as mortality, hatching, presence of malformations, altered heartbeat and animal length were used to assess the effects on three model organisms (<em>Cyprinus carpio, Danio rerio, Xenopus laevis</em>) were evaluated during a 96-hour exposure to six different concentrations of Quaternium-15 (1, 5, 10, 15, 20 and 25 mg/L). The results obtained from the analyses highlighted: significant mortality for all three model organisms in the highest concentrations tested in which all the embryos died after 96 hpf, a delay in hatching of <em>C. carpio</em> and <em>D. rerio</em> compared to the control group<em>,</em> the insurgence of malformations in all the model organisms chosen and a significant decrease in heartbeat rate for the fish models. Each of these observations underlies the negative interaction between the Quaternium-15 and aquatic organisms making necessary further investigation to prevent damage to ecosystems and non-target species.</div></div>","PeriodicalId":248,"journal":{"name":"Aquatic Toxicology","volume":"277 ","pages":"Article 107138"},"PeriodicalIF":4.1,"publicationDate":"2024-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142563464","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluating the impact of the combined acute toxicity of iron (Fe) and microplastics on Namalycastis jaya 评估铁（Fe）和微塑料的综合急性毒性对鲎的影响。

IF 4.1 2区环境科学与生态学

Aquatic Toxicology Pub Date : 2024-10-29 DOI: 10.1016/j.aquatox.2024.107141

Sakthinarenderan Saikumar , Ravi Mani , Swedha Ganesan , Mirunalini Ganesan

{"title":"Evaluating the impact of the combined acute toxicity of iron (Fe) and microplastics on Namalycastis jaya","authors":"Sakthinarenderan Saikumar , Ravi Mani , Swedha Ganesan , Mirunalini Ganesan","doi":"10.1016/j.aquatox.2024.107141","DOIUrl":"10.1016/j.aquatox.2024.107141","url":null,"abstract":"<div><div>The rising concern over heavy metals (HMs) and microplastics (MPs) pollution in marine ecosystems, primarily driven by anthropogenic activities, poses significant threats to ecological health. Understanding the combined exposure of HMs and MPs aids in toxicity assessment. In this study, we examined the combined effects of polystyrene microplastics (MPs) and iron (Fe) on oxidative stress, bioaccumulation, histopathology, and genotoxicity in <em>Namalycastis jaya</em>. Oxidative stress was assessed by analyzing the levels of Superoxide dismutase (SOD), Catalase (CAT), Peroxidase (POD), Malondialdehyde (MDA), and Bicinchoninic acid (BCA), while genotoxicity was evaluated using the comet assay. Bioaccumulation analysis, conducted via Inductively coupled plasma-optical emission spectrometry (ICP-OES), indicated that the highest values (4.790 µg/ml) were observed in combined exposure, emphasizing the significant increase in iron (Fe) accumulation in polychaetes facilitated by MPs. Biochemical analysis revealed that oxidative damage in polychaetes became evident within 48 h of exposure to individual contaminants. However, in the case of combined exposures, elevated stress levels were observed within just 24 h. The genotoxic assay further demonstrated a higher degree of DNA damage in the combined exposure compared to individual exposures. Similarly, histopathology revealed mild alterations in the gut epithelium in combined exposures. It is evident that MPs intensify both oxidative and DNA damage induced by Fe in polychaetes. The insights gained from this study provide valuable information for the risk assessment of Fe and MPs in environmental safety, contributing to our understanding of the complex interactions between these pollutants in marine ecosystems.</div></div>","PeriodicalId":248,"journal":{"name":"Aquatic Toxicology","volume":"277 ","pages":"Article 107141"},"PeriodicalIF":4.1,"publicationDate":"2024-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142613374","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Azoxystrobin induced genotoxicity in Pethia conchonius, a freshwater fish of river Teesta, India 印度 Teesta 河淡水鱼 Pethia conchonius 在唑啉草酯诱导下的遗传毒性。

IF 4.1 2区环境科学与生态学

Aquatic Toxicology Pub Date : 2024-10-28 DOI: 10.1016/j.aquatox.2024.107135

Arpita Ray, Debojit Dutta, Bappaditya Ghosh, Min Bahadur

{"title":"Azoxystrobin induced genotoxicity in Pethia conchonius, a freshwater fish of river Teesta, India","authors":"Arpita Ray, Debojit Dutta, Bappaditya Ghosh, Min Bahadur","doi":"10.1016/j.aquatox.2024.107135","DOIUrl":"10.1016/j.aquatox.2024.107135","url":null,"abstract":"<div><div>Azoxystrobin, a widely used fungicide, can contaminate water bodies through surface run-off, posing a risk to aquatic organisms. This study aimed to assess the genotoxic effects of azoxystrobin on the fish <em>Pethia conchonius</em>. The 96 h lethal concentration (LC<sub>50</sub>) of azoxystrobin was determined to be 0.514 mg/L. Based on LC<sub>50,</sub> three sub-lethal concentrations (SLCs) of 0.025 mg/L, 0.0514 mg/L, and 0.103 mg/L were used to expose fish for 96 h. The blood and gill samples were collected at 24 h intervals for analysis. The Micronucleus (MN) and Comet assays were used to evaluate nuclear abnormalities and DNA damage, respectively. The results showed that the frequency of nuclear abnormalities and DNA damage in the exposed groups was significantly higher than the control, with increasing concentrations and duration of exposure. The highest levels of micronuclei, notched and blebbed nuclei, and DNA damage parameters were observed in the group exposed to SLC III for 96 h. These findings indicate that azoxystrobin is highly genotoxic to fish causing severe DNA damage.</div></div>","PeriodicalId":248,"journal":{"name":"Aquatic Toxicology","volume":"277 ","pages":"Article 107135"},"PeriodicalIF":4.1,"publicationDate":"2024-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142563410","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0