Aquatic Toxicology最新文献

{"title":"Bioaccumulation and toxicokinetics of arsenite (As III) in the aquatic bioindicator Pomacea canaliculata using radiotracer analysis","authors":"Andrea Juarez ,&nbsp;Alejandra D. Campoy-Diaz ,&nbsp;Luis S. Mayorga ,&nbsp;María A. Arribére ,&nbsp;Israel A. Vega","doi":"10.1016/j.aquatox.2025.107243","DOIUrl":"10.1016/j.aquatox.2025.107243","url":null,"abstract":"<div><div>This study examines the kinetics of absorption, distribution and accumulation of arsenite (As III) in the freshwater gastropod <em>Pomacea canaliculata</em> using a short-lived tracer (⁷⁶As III). The toxicokinetic model indicate that the gills play a crucial role in the As III uptake, with uptake rates significantly exceeding those of release back into the aquatic environment. The movement of As III from the gills to the hemolymph has low exchange rate. The hemolymph acts as a convective transport medium, facilitating the distribution of As III to various organs of accumulation and elimination within the snail. The majority of As III detected in the hemolymph is directed toward the kidney, stomach, coiled gut and digestive gland. Following feeding, the maximum As inventory (90 %) was reached at 24 h, after which an elimination phase with approximately 4 % between 24 and 96 h According to our toxicokinetic model, feces is the primary route of elimination would be. By 96 h, As III is localized in the digestive gland (70 %) and visceral mass (6 %). Furthermore, tissue accumulation shows a linear correlation with increasing As III concentrations in the surrounding water. By integrating ⁷⁶As radiotracer assays with physiological information, we gain valuable insights in the toxicokinetic of both As III and As V. We hypothesize that biotransformation may occur between these two inorganics As forms at the tissue level.</div></div>","PeriodicalId":248,"journal":{"name":"Aquatic Toxicology","volume":"279 ","pages":"Article 107243"},"PeriodicalIF":4.1,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142989638","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The impact of bisphenol A on gill health: A focus on mitochondrial dysfunction induced disorders of energy metabolism and apoptosis in Meretrix petechialis","authors":"Xiaotian Wang ,&nbsp;Shangjie Zhou ,&nbsp;Jianhao Dong ,&nbsp;Zhengjia Wei ,&nbsp;Yan Liu ,&nbsp;Yutong Huang ,&nbsp;Junhui Sui ,&nbsp;Long Zhu","doi":"10.1016/j.aquatox.2025.107259","DOIUrl":"10.1016/j.aquatox.2025.107259","url":null,"abstract":"<div><div>Bisphenol A (BPA), a well-known chemical compound used in various daily goods, has been associated with adverse effects on animal metabolic processes. However, the specific impacts of BPA exposure on clam gills remain largely unexplored. To investigate the effects of BPA on energy metabolism and apoptosis in <em>Meretrix petechialis</em> gills, clams were exposed to varying concentrations of BPA (1, 10, and 100 μg/L) for 21 days. Results showed that BPA exposure induced gill histopathological injuries and inhibited filtration rates. Transmission electron microscopy (TEM) analysis revealed mitochondrial injury and dysfunction as potential mechanisms of gill damage. Transcriptome analysis identified differentially expressed genes (DEGs) primarily enriched in energy metabolism and apoptosis pathways. BPA-induced changes in ATP content, ATPase, and lactate dehydrogenase (LDH) activities suggested dysregulation of energy metabolism. TUNEL staining demonstrated enhanced apoptotic signals with increasing BPA concentrations. Activation of the caspase-3/9 pathway indicated a concentration-dependent, mitochondria-dependent apoptotic process. Additionally, the expression of genes associated with mitochondria (<em>NNT, TOMM40</em>, and <em>SLC25A11</em>), energy metabolism (<em>PCK1</em> and <em>pdhC</em>), inducing mitochondria-dependent apoptosis (<em>NFKB1, RAC1</em>, and <em>TRAF2</em>), and oxidative stress (<em>GSTT1</em>) was affected by BPA exposure. Integrated biomarker response version 2 (IBRv2) values further confirmed a concentration-dependent gill toxicity of BPA via the mitochondrial pathway. These findings provide a deeper understanding of the toxicological mechanisms underlying BPA-induced toxicity in bivalves and contribute to assessing the risks posed by BPA in benthic ecosystems.</div></div>","PeriodicalId":248,"journal":{"name":"Aquatic Toxicology","volume":"279 ","pages":"Article 107259"},"PeriodicalIF":4.1,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143057617","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mitigating oxidative stress in oyster larvae: Curcumin promotes enhanced redox balance, antioxidant capacity, development, and resistance to antifouling compounds","authors":"Heloísa Bárbara Gabe ,&nbsp;Fernando Ramos Queiroga ,&nbsp;Karine Amabile Taruhn ,&nbsp;Rafael Trevisan","doi":"10.1016/j.aquatox.2024.107231","DOIUrl":"10.1016/j.aquatox.2024.107231","url":null,"abstract":"<div><div>Curcumin (CUR) is a natural compound recognized for stimulating the expression of antioxidant genes. This characteristic has been used to promote animal health and production in aquaculture settings. We hypothesized that supplementing embryos of <em>Crassostrea gigas</em> oysters with CUR would improve their antioxidant capacity, development, and resilience to stress. Embryos were exposed to CUR ranging from 0.03 to 30 µM for 24 h. Their development was assessed, along with measurements of glutathione levels, glutathione S-transferase activity, antioxidant capacity, production of reactive oxygen species (ROS), metabolic activity, and resistance to organic hydroperoxide and the antifouling compound dichlorooctylisothiazolinone (DCOIT). Low curcumin concentrations (up to 1 μM) activated the <span>d</span>-larvae antioxidant system, with a significant threefold increase in glutathione levels and a 50 % decrease in ROS production. This enhancement in antioxidant defense improved the ability of larvae to detoxify organic hydroperoxide. It also resulted in larger larval size and increased survival rates, whether under normal conditions or exposure to peroxide or DCOIT. CUR shows great promise in supporting larval development, but high concentrations were toxic (EC₅₀ = 2.90 μM), probably due to excessive antioxidant activation. Our results indicate that the antioxidant system may play a role in controlling bivalve early development. Understanding how antioxidants influence redox balance and gene expression during early life can enhance our knowledge of stress response mechanisms in marine organisms, offering insights into how they cope with pollutants and environmental challenges. Integrating CUR and antioxidant defense pathway approaches into aquaculture practices could boost productivity and sustainability in oyster aquaculture.</div></div>","PeriodicalId":248,"journal":{"name":"Aquatic Toxicology","volume":"279 ","pages":"Article 107231"},"PeriodicalIF":4.1,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142925332","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Phenanthrene toxicity during early development of the neotropical tree frog Dendropsophus branneri","authors":"Natallia Vívian Nascimento da Silva Maia ,&nbsp;Maria Karolaine de Melo Alves ,&nbsp;Célio Freire Mariz Jr ,&nbsp;Pedro Ivo Simões ,&nbsp;Paulo Sérgio Martins de Carvalho","doi":"10.1016/j.aquatox.2025.107239","DOIUrl":"10.1016/j.aquatox.2025.107239","url":null,"abstract":"<div><div>Phenanthrene is considered a priority polycyclic aromatic hydrocarbon due to its ubiquitous presence in aquatic and terrestrial environments and its toxic potential. Tadpoles are sensitive ecotoxicological models that provide important information regarding effects of contaminants in amphibian species. The goal of the present study was to generate information regarding the acute and chronic toxicity of phenanthrene to the neotropical tree frog <em>Dendropsophus branneri</em> early life stages. Tadpoles at Gosner stage 25 were exposed to environmentally relevant concentrations of 10.8, 18.6, 76.2, 187.7, and 279.6 µg phenanthrene L⁻¹ in two experiments with 15 and 60 days of exposure. Lethality, progression of development, final weight, swimming behavior and enzymatic biomarkers were analyzed. The lethal concentration of dissolved phenanthrene for 50 % of <em>D. branneri</em> tadpoles after 15 days of exposure was 154.8 µg L⁻¹, typical of a sensitive species. Significant developmental delay was verified, with a lowest observed effect concentration (LOEC) of 76.2 µg L⁻¹ and 10.8 µg L⁻¹ after exposures of 15 and 60 days, respectively. Delay was measured based on the difference between the mean Gosner stage of controls and exposed tadpoles (Delta_gosner). Delta_gosner after 60 days of exposure ranged from 10 at 10.8 µg L⁻¹ to 13 at 187.7 µg L⁻¹, and tadpoles remained in the early stages of hind limb development (Gosner stages 28–32), in contrast to controls that reached stage 42 with fully formed forelimbs and hind limbs with toes at metamorphic climax. Glutathione-S-transferase and Catalase were induced in exposed tadpoles, possibly due to oxidative stress. Thigmotaxis was decreased in phenanthrene exposed tadpoles, indicating loss of anti-predatory behaviors. Final wet weight of exposed <em>D.branneri</em> tadpoles significantly decreased. Delayed development and slower growth rate are crucial factors for tadpole survival, and these effects of phenanthrene on <em>D.branneri</em> early stages potentially affects its recruitment to the adult stage.</div></div>","PeriodicalId":248,"journal":{"name":"Aquatic Toxicology","volume":"279 ","pages":"Article 107239"},"PeriodicalIF":4.1,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142967805","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gender-specific effects of dydrogesterone on zebrafish liver metabolism after long-term exposure","authors":"Yu-Xia Jiang ,&nbsp;Jian-Nan Guo ,&nbsp;Li-Xin Hu ,&nbsp;Hui Zhang ,&nbsp;Choon-Nam Ong ,&nbsp;Wen-Jun Shi ,&nbsp;Guang-Guo Ying","doi":"10.1016/j.aquatox.2025.107236","DOIUrl":"10.1016/j.aquatox.2025.107236","url":null,"abstract":"<div><div>Synthetic progestin dydrogesterone is widely used in gynecology and animal husbandry, leading to high environmental detection rates and concentrations. Dydrogesterone influences sex differentiation, gonad development, and spawning in fish. However, its impact on the liver, a vital organ for hormone production and detoxification, remains largely unknown. In this study, zebrafish embryos were exposed to 2.8, 27.6, and 289.8 ng/L of dydrogesterone until they reached sexual maturity. Metabolomics and Fourier transform infrared spectroscopy (FTIR) were employed to investigate alterations in the zebrafish liver. Long-term exposure to dydrogesterone decreased body weight and length in females but increased them in males. The levels of phospholipids, monoglycerides, lysophospholipids, fatty acids, acylcarnitines, acyltaurines, cholesterol, and bile acids increased in the liver of females but decreased in males due to dydrogesterone, making the metabolic pathways the most affected. FTIR analysis revealed a reduction in lipid and protein absorption coupled with an increase in carbohydrate absorption in the liver of exposed males, whereas exposed females exhibited reductions in both lipid and carbohydrate absorption. These findings suggest that long-term exposure to dydrogesterone enhances basic metabolism and physical growth in male zebrafish. To the best of our knowledge, this is the first report on the effects of progestins on body metabolism. Additionally, we find that gender difference is a notable feature of the effects of dydrogesterone on zebrafish.</div></div>","PeriodicalId":248,"journal":{"name":"Aquatic Toxicology","volume":"279 ","pages":"Article 107236"},"PeriodicalIF":4.1,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142967816","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cnidarian models for toxicology","authors":"A.H. Ringwood ,&nbsp;M. Lowder ,&nbsp;E. Provance ,&nbsp;J. O'Dea ,&nbsp;T. Gaspar ,&nbsp;K.R.W. Latijnhouwers ,&nbsp;V.F. Chamberland ,&nbsp;M.J.A. Vermeij","doi":"10.1016/j.aquatox.2025.107265","DOIUrl":"10.1016/j.aquatox.2025.107265","url":null,"abstract":"<div><div>Coral reefs and tropical habitats are threatened worldwide by global warming and pollution stress. The purpose of these studies was to evaluate potential strategies for using jellyfish for toxicological assessments and as potential toxicological models for corals and other Cnidarians. Laboratory studies were conducted with jellyfish and three species of corals that were exposed to copper; and studies with corals exposed to pyrene and elevated temperatures were conducted. Observational (pulsation rate in jellyfish and bleaching in corals) as well as cellular biomarker responses (glutathione (GSH), lysosomal destabilization, and tissue Cu in jellyfish; GSH in corals) were assessed. Jellyfish pulsation rate, lysosomal destabilization, and tissue Cu levels were significantly correlated. Likewise, GSH levels were significantly correlated with tissue Cu, lysosomal destabilization and pulsation rates. Jellyfish tended to be more sensitive than corals to Cu exposures. Studies were conducted with adults and larvae of brain corals and other species from Curaçao to determine the baseline glutathione levels. Glutathione levels of these Cnidarians were much lower than those of more traditional bioindicators such as mussels or oysters. Glutathione levels of adult jellyfish were lower than adult coral levels. The GSH levels of early life history stages of corals (especially larvae) were lower than adult levels, potentially indicating that these stages could be more sensitive than adults. The GSH levels of the younger coral stages were similar to the GSH levels of jellyfish adults. Species-specific differences in the sensitivity of corals to the different pollutants were observed. This work was facilitated by partnerships with Discovery Place Science (a public science exploration center), CARMABI (Caribbean Research and Management of Biodiversity), and SECORE International which are actively engaged in the culture of Cnidarians and marine educational programs.</div></div>","PeriodicalId":248,"journal":{"name":"Aquatic Toxicology","volume":"281 ","pages":"Article 107265"},"PeriodicalIF":4.1,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143487326","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"From plankton to fish: The multifaceted threat of microplastics in freshwater environments","authors":"Cuimei Gao ,&nbsp;Baohong Xu ,&nbsp;Zhongyuan Li ,&nbsp;Zhuoman Wang ,&nbsp;Siqi Huang ,&nbsp;Zijian Jiang ,&nbsp;Xiaomin Gong ,&nbsp;Huilin Yang","doi":"10.1016/j.aquatox.2025.107242","DOIUrl":"10.1016/j.aquatox.2025.107242","url":null,"abstract":"<div><div>The detrimental impact of emerging pollutants, specifically microplastics (MPs), on the ecological environment are receiving increasing attention. Freshwater ecosystems serve as both repositories for terrestrial microplastic (MP) sources and conduits for their subsequent entry into marine environments. Consequently, it is imperative to rigorously investigate the toxicological effects of MPs on freshwater ecosystems. This article provides a comprehensive analysis of the ecological toxicity effects of MP pollution, both in isolation and in combination with other pollutants, on freshwater aquatic organisms, including plankton, benthic organisms, and fish. The review elucidates potential mechanisms underlying these effects, which encompass oxidative stress, metabolic disorders, immune and inflammatory responses, dysbiosis of the gut microbiota, DNA damage, and cell apoptosis. This paper advocates for the integrated application of multi-omics technologies to investigate the molecular mechanisms underlying the toxicity of MPs to freshwater aquatic organisms from interdisciplinary and multifaceted perspectives. Additionally, it emphasizes the importance of enhancing research on the compounded pollution effects arising from various pollution modes, particularly in conjunction with other pollutants. This study aims to establish a foundation for assessing the ecological risks posed by MPs in freshwater ecosystem and offers valuable insights for the protection of aquatic biodiversity and ecosystem stability.</div></div>","PeriodicalId":248,"journal":{"name":"Aquatic Toxicology","volume":"279 ","pages":"Article 107242"},"PeriodicalIF":4.1,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142967803","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Developmental and neurotoxic effects of dimethyl phthalate on zebrafish embryos and larvae","authors":"Weili Yang ,&nbsp;Ruijing Li ,&nbsp;Xingxue Yan ,&nbsp;Pengkai Fan ,&nbsp;Weyland Cheng ,&nbsp;Cuihua Liu ,&nbsp;Yaodong Zhang ,&nbsp;Jitong Li","doi":"10.1016/j.aquatox.2025.107241","DOIUrl":"10.1016/j.aquatox.2025.107241","url":null,"abstract":"<div><div>Dimethyl phthalate (DMP) has been extensively utilized as a plasticizer on a global scale for many years. Its presence in the environment and its harmful effects on living organisms have raised concerns. This study aimed to examine its potential developmental neurotoxicity by utilizing zebrafish as a model. Zebrafish embryos were exposed to different concentrations of DMP (5–100 mg/L) from 4 to 120 h post-fertilization (hpf). The survival, hatching, and malformation rates were recorded for each group. Behavioral analysis was conducted on zebrafish larvae, and transgenic zebrafish Tg(<em>elavl3</em>:EGFP) were used to assess the impact of DMP on neuronal cells. The mRNA levels of key neurological marker genes were evaluated at 96 hpf of DMP exposure. The study revealed that exposure to DMP resulted in decreased survival and hatching rates in zebrafish. Embryos treated with 50 mg/L of DMP exhibited lower average survival rates (72.78–78.33%) between 24–96 hpf, while treatment with 25–50 mg/L of DMP resulted in reduced hatching rates (39.44% and 2.22%, respectively) at 48 hpf compared to the control group. Moreover, exposure to 25–50 mg/L of DMP caused an increase in malformations, such as tail curvature, spinal curvature, yolk sac edema and pericardial edema. Interestingly, at 24 hpf, DMP also resulted in an increase in spontaneous tail coiling in zebrafish embryos, as well as a decrease in their swimming distance at 120 hpf. Furthermore, treatment with 50 mg/L of DMP led to a decrease in the fluorescence intensity of transgenic zebrafish Tg(<em>elavl3</em>: EGFP). RT-qPCR analysis showed a significant down-regulation of marker genes (<em>gap43, mbp, α1-tubulin, syn2a</em>) associated with nervous system function in DMP-treated zebrafish. Overall, these findings offer a thorough understanding of the mechanisms underlying the neurotoxicity caused by DMP, highlighting the risk of DMP on developmental and neurotoxic effects in zebrafish. Therefore, strict supervision of DMP use and release is essential to safeguard ecological and aquatic organisms.</div></div>","PeriodicalId":248,"journal":{"name":"Aquatic Toxicology","volume":"279 ","pages":"Article 107241"},"PeriodicalIF":4.1,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142967814","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Harmful effects of the semiconductor copper tungstate (CuWO4) on multiple photosynthetic parameters of the green microalga Raphidocelis subcapitata","authors":"Renan Castelhano Gebara ,&nbsp;Cínthia Bruno de Abreu ,&nbsp;Giseli Swerts Rocha ,&nbsp;Adrislaine da Silva Mansano ,&nbsp;Marcelo Assis ,&nbsp;Ailton José Moreira ,&nbsp;Mykaelli Andrade Santos ,&nbsp;Thalles Maranesi Pereira ,&nbsp;Luciano Sindra Virtuoso ,&nbsp;Maria da Graça Gama Melão ,&nbsp;Elson Longo","doi":"10.1016/j.aquatox.2025.107245","DOIUrl":"10.1016/j.aquatox.2025.107245","url":null,"abstract":"<div><div>The semiconductor copper tungstate (CuWO₄) may end up in aquatic ecosystems since it has the potential for water decontamination. The toxic effects of CuWO₄ are totally unknown for eukaryotic organisms. In view of this, we aimed to evaluate the toxicity of CuWO₄ particles (size of 161.5 nm) on the cosmopolitan green microalga <em>Raphidocelis subcapitata</em> (a standardized test-organism for ecotoxicological assays), analyzing the growth and multiple photosynthetic parameters obtained by pulse amplitude modulated (PAM) fluorometry. At 1.2 mg <span>l</span>^-1, the growth was affected, and there was an increase in reactive oxygen species (ROS) after 72 h The effective efficiency (ɸ_M’) of photosystem II (PSII) was affected at 13.1 mg <span>l</span>^-1, while the efficiency of the oxygen-evolving complex (OEC), responsible for the water-splitting process, decayed at 5.6 mg <span>l</span>^-1. According to quenching parameters, energy allocated to photosynthetic processes (qP) decreased, indicating a malfunctioning of the PSII. We also observed a 50 % increase in the non-regulated energy dissipation by heat and fluorescence (Y(NO)), and a 50 % decrease in the regulated energy dissipation (NPQ), suggesting difficulties for algae to cope with light. Rapid light curves (RLC) were the second most sensitive parameter, as we observed a decay of the relative maximum electron transport rate (rETRmax) at 2.8 mg <span>l</span>^-1. Therefore, since the microalga <em>R. subcapitata</em> was affected by concentrations up to 1.2 mg <span>l</span>^-1 (0.01 mg <span>l</span>^-1 dissolved Cu), it is important to evaluate carefully the use of CuWO₄ to decontaminate natural waters, considering the protection of the aquatic biota.</div></div>","PeriodicalId":248,"journal":{"name":"Aquatic Toxicology","volume":"279 ","pages":"Article 107245"},"PeriodicalIF":4.1,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142989643","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessing spinel zinc ferrite nanoparticles in aquatic ecosystems: Toxic threat or beneficial detoxifier for aquatic life?","authors":"Selin Ertürk Gürkan ,&nbsp;Mert Gürkan ,&nbsp;Ece Büşra Yanik ,&nbsp;Elif Kutlu ,&nbsp;Volkan Saritunç ,&nbsp;Berkay Güneş ,&nbsp;Ezgi Can İbiş","doi":"10.1016/j.aquatox.2024.107218","DOIUrl":"10.1016/j.aquatox.2024.107218","url":null,"abstract":"<div><div>The effectiveness of magnetic nanoparticles in removing pollutants during water treatment is well established, but their introduction into aquatic ecosystems raises significant toxicity concerns. This study investigates the histological and physiological effects of zinc ferrite magnetic nanoparticles (ZnFe₂O₄₋MNPs) on the Mediterranean mussel (<em>Mytilus galloprovincialis</em>) and examines the impact of concurrent exposure to these nanoparticles and the insecticide thiomethoxam (TMX).</div><div>Mussels were exposed to nominal concentrations of ZnFe₂O₄₋MNPs (1, 10, 100 mg/L) both individually and with TMX. Physiological assessments included measuring antioxidant enzyme levels (superoxide dismutase, catalase, glutathione <em>S</em>-transferase) and oxidative stress markers (malondialdehyde). Results showed that ZnFe₂O₄₋MNPs increased antioxidant activity but also caused dose-dependent pathological changes. In contrast, combined exposure with TMX significantly (<em>p</em> &lt; 0.05) reduced antioxidant defenses, indicated by lower superoxide dismutase (SOD) levels and higher malondialdehyde (MDA) concentrations, suggesting oxidative stress and potential cellular damage.</div><div>These findings highlight the need for comprehensive toxicity assessments of nanoparticles in aquatic environments and advocate for their complete removal from water sources post-treatment. Further research is crucial to define the toxicity profiles of spinel ferrites to ensure their safe application in environmental remediation.</div></div>","PeriodicalId":248,"journal":{"name":"Aquatic Toxicology","volume":"279 ","pages":"Article 107218"},"PeriodicalIF":4.1,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142989644","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}