Individual and combined toxicity of personal care products and pharmaceuticals at environmentally relevant concentrations due to chronic exposure of the freshwater microcrustacean Daphnia magna

IF 4.1 2区环境科学与生态学 Q1 MARINE & FRESHWATER BIOLOGY

Aquatic Toxicology Pub Date : 2025-03-03 DOI:10.1016/j.aquatox.2025.107307

Alana Rafaela Batista Leite , Silvia Pedroso Melegari , William Gerson Matias

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引用次数: 0

Abstract

Personal care products and pharmaceuticals, namely sodium diclofenac (DCF), octocrylene (OCT), and sodium dodecyl sulfate (SDS), are relevant chemical products classified as contaminants of emerging concern (CECs). They can enter aquatic ecosystems from various anthropogenic sources. This study examined the acute and chronic toxic effects of exposure to these substances, individually and in binary mixtures (OCT + SDS, SDS + DCF, DCF + SDS). Chronic effects were evaluated at environmentally relevant concentrations. To evaluate the mixtures, the Abbott method was used to predict acute toxicity using the inhibition ratio value, while for chronic effects, the concentration addition (CA) and independent action (IA) models were used for predictive assessment. According to EC50_48h values, the toxicity levels to D. magna were OCT > SDS > DCF. When exposed to binary mixtures, these compounds predominantly exhibited antagonistic interaction for acute effects. Regarding chronic effects, there were no observed effects at the environmentally relevant concentrations tested for individual and mixed exposure compared to the control. The locomotion parameter exhibited a difference in dispersion with increasing chemical concentration. These results can improve understanding of the damage produced by exposure to mixtures of different CECs.

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来源期刊

Aquatic Toxicology 环境科学-毒理学

CiteScore

7.10

自引率

4.40%

发文量

250

审稿时长

56 days

期刊介绍： Aquatic Toxicology publishes significant contributions that increase the understanding of the impact of harmful substances (including natural and synthetic chemicals) on aquatic organisms and ecosystems. Aquatic Toxicology considers both laboratory and field studies with a focus on marine/ freshwater environments. We strive to attract high quality original scientific papers, critical reviews and expert opinion papers in the following areas: Effects of harmful substances on molecular, cellular, sub-organismal, organismal, population, community, and ecosystem level; Toxic Mechanisms; Genetic disturbances, transgenerational effects, behavioral and adaptive responses; Impacts of harmful substances on structure, function of and services provided by aquatic ecosystems; Mixture toxicity assessment; Statistical approaches to predict exposure to and hazards of contaminants The journal also considers manuscripts in other areas, such as the development of innovative concepts, approaches, and methodologies, which promote the wider application of toxicological datasets to the protection of aquatic environments and inform ecological risk assessments and decision making by relevant authorities.