Immunotoxicity of thyroid hormone system disrupting compounds in fish

IF 4.1 2区环境科学与生态学 Q1 MARINE & FRESHWATER BIOLOGY

Aquatic Toxicology Pub Date : 2025-03-03 DOI:10.1016/j.aquatox.2025.107309

Florentina Hasani , Lisa Baumann

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引用次数: 0

Abstract

Endocrine disrupting compounds (EDCs) are among the most studied environmental pollutants in the field of (eco)toxicology, and different fish species are commonly used as model organisms, especially for studying reprotoxic effects. Despite the scientific and regulatory importance of EDCs, little attention has been given to their immunotoxic effects in fish. Basic knowledge and test systems for immune-related outcomes in fish are limited. For example, while the impact of estrogenic EDCs on the fish immune system has raised some attention in the last decade, thyroid hormone system disrupting compounds (THSDCs) and their impact on the fish immune system are less well studied. Thus, this literature review is aimed at describing the immunomodulatory roles of thyroid hormones (THs), as well as summarizing the existing research on the immunotoxicity of THSDCs in fish. A simplified potential adverse outcome pathway (AOP) was created, explaining the key events between THSD and lowered survival of fish experiencing pathogen infections along with chemical exposure. This AOP demonstrates that THSDCs can alter immune system functioning on a molecular, cellular, and organism level and, therefore, lead to reduced survival by lowering pathogen resistance of fish. However, available data were mainly limited to molecular analyses of immune-related biomarkers and included only few studies that conducted experiments demonstrating immunotoxic effects at organism level that can inform about population-relevant outcomes. Our putatively developed and simplified AOP can support the incorporation of immune-related endpoints in EDC testing guidelines and aid the development of risk assessments for THSDCs for human and environmental health.

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来源期刊

Aquatic Toxicology 环境科学-毒理学

CiteScore

7.10

自引率

4.40%

发文量

250

审稿时长

56 days

期刊介绍： Aquatic Toxicology publishes significant contributions that increase the understanding of the impact of harmful substances (including natural and synthetic chemicals) on aquatic organisms and ecosystems. Aquatic Toxicology considers both laboratory and field studies with a focus on marine/ freshwater environments. We strive to attract high quality original scientific papers, critical reviews and expert opinion papers in the following areas: Effects of harmful substances on molecular, cellular, sub-organismal, organismal, population, community, and ecosystem level; Toxic Mechanisms; Genetic disturbances, transgenerational effects, behavioral and adaptive responses; Impacts of harmful substances on structure, function of and services provided by aquatic ecosystems; Mixture toxicity assessment; Statistical approaches to predict exposure to and hazards of contaminants The journal also considers manuscripts in other areas, such as the development of innovative concepts, approaches, and methodologies, which promote the wider application of toxicological datasets to the protection of aquatic environments and inform ecological risk assessments and decision making by relevant authorities.