Analytica Chimica Acta最新文献

{"title":"Three-Dimensional CeO2 Nanosheets/CuO Nanoflowers p-n Heterostructure Supported on Carbon Cloth as Electrochemical Sensor for Sensitive Nitrite Detection","authors":"Jingwen Zhang, Haoyu Jiang, Jie Gao, Chun Zhao, Hui Suo","doi":"10.1016/j.aca.2024.343526","DOIUrl":"https://doi.org/10.1016/j.aca.2024.343526","url":null,"abstract":"<h3>Background</h3>Nitrite is widely used as a food additive, and it is of great significance to realize accurate detection of nitrite for food safety. Electrochemical technique is characterized by simple operation and portability, which enables rapid and accurate detection. The key factors affecting the nitrite detection performance are the electrocatalytic activity and interfacial electron transfer efficiency of the electrode. The electrochemical oxidation of nitrite typically requires high potentials, posing challenges for detection. <strong>Therefore, we need to develop a high-performance sensitive electrode to fulfill the need for efficient detection of nitrite</strong>. (89)<h3>Results</h3>We designed a novel CeO₂ nanosheets/CuO nanoflowers p-n heterostructure supported on carbon cloth, which was used to construct an electrochemical sensor for nitrite. The p-CuO NFs/n-CeO₂ NSs heterojunction produced charge transfer effects and strong electronic interactions, which contributed to the increase in oxygen vacancies and enhanced the electrocatalytic activity. During electrochemical oxidation of nitrite, the p-n heterojunction achieved more efficient carrier separation, increasing the number of free electrons in the conduction band and facilitating charge transport. The electrode combines CuO nanoflowers with labyrinthine CeO₂ nanosheets, significantly enhancing the electrochemically active surface area and availability of active sites, improving electron conduction efficiency and improving mass transfer efficiency. The CeO₂ NSs/CuO NFs/CC showed significantly enhanced current response for the oxidation of nitrite, such as the sensitivity of 11610 μA mM⁻¹cm⁻², the linear determination range of 0.1 - 4000 μM, the LOD of 0.037 μM (S/N=3). (143)<h3>Significance</h3>This work combines binary metal oxide p-n heterojunction with three-dimensional morphology optimization to design sensitive electrode with enhanced nitrite sensing performance, reduced oxidation potential and improved sensitivity. And the prepared electrode can rapidly and accurately detect nitrite residues in food samples. This work provides a high-performance nitrite electrochemical sensing platform with great practical applications. (54)","PeriodicalId":240,"journal":{"name":"Analytica Chimica Acta","volume":"83 1","pages":""},"PeriodicalIF":6.2,"publicationDate":"2024-12-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142776834","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Engineering Interference-Removal and Target-Response Cascade Zones on Wood Channels for Straightforward Detection of Uric Acid in Saliva","authors":"Junjian Zhao, Junli Guo, Junhan Li, Chenxi Zhao, Zhida Gao, Yan-Yan Song, Xiaona Li","doi":"10.1016/j.aca.2024.343522","DOIUrl":"https://doi.org/10.1016/j.aca.2024.343522","url":null,"abstract":"The detection of biomarkers is crucial for assessing disease status and progression. Uric acid (UA), a common biomarker in body fluids, plays an important role in the diagnosis and monitoring of conditions such as hyperuricemia, chronic kidney disease, and cardiovascular disease. However, the low concentration of UA in non-invasive body fluids, combined with numerous interfering substances, makes its detection challenging. Therefore, there is a pressing need to develop advanced sensor platforms that exhibit both high sensitivity and excellent specificity for accurate monitoring of UA levels in various body fluids. In this study, an electrochemical sensing system is developed by integrating a cascade interference-removal zone and a target-response zone on a wooden channel membrane (CM) for the pretreatment-free detection of UA in body fluids. In this design, cysteine-doped ZIF-67(Co) nanocrystals, a mimic with multi-enzyme activity, are modified in the interference-removal zone. The target-response zone on the other side of the CM is contacted with a solution containing Fe³⁺ and [Fe(CN)₆^]3– ions. Using saliva as a proof-of-concept, the interference species, including ascorbic acid (AA), dopamine (DA), and glutathione (GSH), are oxidized and removed when passing through the interference-removal zone, while UA reaches the target-response zone and triggers the growth of Prussian blue (PB) on site. Utilizing the peroxidase-like activity of PB, UA concentration is directly determined based on changes in transmembrane ion currents. The resulting sensing system exhibits higher sensitivity than commercial UA meters and demonstrates straightforward, continuous, and non-invasive monitoring of UA in saliva after consuming purine-rich foods. The technology provides a simple, reliable and low-cost device for sensing UA in complex biological matrices. Moreover, the CM based sensing device also provides the benefit of being incineratable and biodegradable, reducing medical and electronic waste, making it eco-friendly for daily diagnostics.","PeriodicalId":240,"journal":{"name":"Analytica Chimica Acta","volume":"26 1","pages":""},"PeriodicalIF":6.2,"publicationDate":"2024-12-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142763291","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Introduction of curvature index and improvement of calibration curves used in ion chromatography (IC), atomic absorption spectrometry (AAS), UV-Vis spectrophotometry and catalytic combustion","authors":"Andrei Chilian","doi":"10.1016/j.aca.2024.343521","DOIUrl":"https://doi.org/10.1016/j.aca.2024.343521","url":null,"abstract":"<h3>Background</h3>The calibration curve represents the relationship between known CRM and the response of the instrument (e.g absorbance). Most of the time, in analytical chemistry standards, the linear function (of the 1st degree) is used to characterize the calibration curves. This, at first glance, has some major advantages: simple equation, simple linearity estimation criterion, and easy way of calculation. <strong>However, from a quality point of view, the grade 1 calibration curve does not characterize a working domain very well, because it does not take into account the curvature and has larger residuals.</strong><h3>Results</h3>Here we show that, most of the time, the non-linear secondary function fits the calibration curves much better (argument valid for UV-Vis spectrophotometry, atomic absorption spectrometry (FAAS and ETAAS), catalytic combustion and ion chromatography (IC)), having lower residuals, but also a higher coefficient of determination, <span><span style=\"\"></span><span data-mathml='&lt;math xmlns=\"http://www.w3.org/1998/Math/MathML\" /&gt;' role=\"presentation\" style=\"font-size: 90%; display: inline-block; position: relative;\" tabindex=\"0\"><svg aria-hidden=\"true\" focusable=\"false\" height=\"0.24ex\" role=\"img\" style=\"vertical-align: -0.12ex;\" viewbox=\"0 -51.7 0 103.4\" width=\"0\" xmlns:xlink=\"http://www.w3.org/1999/xlink\"><g fill=\"currentColor\" stroke=\"currentColor\" stroke-width=\"0\" transform=\"matrix(1 0 0 -1 0 0)\"></g></svg><span role=\"presentation\"><math xmlns=\"http://www.w3.org/1998/Math/MathML\"></math></span></span><script type=\"math/mml\"><math></math></script></span>. The limitation of the secondary non-linear function use is given by the insufficiency of data related to its qualitative characterization. Through this work, we have introduced new characterization criteria for non-linear secondary functions such as curvature angle and curvature index. Although in the specialized literature, the term linearity of the calibration curve has existed for a long time, in reality it has not been fully interpreted. The curvature index developed in this work allows the controlled implementation of non-linear curves, but also with increasing the precision of the results. (135)<h3>Significance</h3>The curvature index characterizes the degree of curvature of the 1^st or 2^nd degree calibration functions. Using the 2nd degree calibration function allows the improvement of the obtained results, and curvature parameters (curvature angle and curvature index) allow qualitative characterization of many data sets used for calibration. The degree of curvature of a calibration curve is a new term not found in the literature, which will allow their characterization from a qualitative point of view. (75)","PeriodicalId":240,"journal":{"name":"Analytica Chimica Acta","volume":"13 1","pages":""},"PeriodicalIF":6.2,"publicationDate":"2024-12-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142760681","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Structure-switchable branched inhibitors regulate the activity of CRISPR-Cas12a for nucleic acid diagnostics","authors":"Xingrong Li, Cuixiang Wang, Jiatong Chai, Hongmao Liu, Xinli Jiang, Yumei Li, Yirong Li","doi":"10.1016/j.aca.2024.343515","DOIUrl":"https://doi.org/10.1016/j.aca.2024.343515","url":null,"abstract":"<h3>Background</h3>In current years, the CRISPR (clustered regularly interspaced short palindromic repeats) based strategies have emerged as the most promising molecular tool in the field of gene editing, intracellular imaging, transcriptional regulation and biosensing. However, the recent CRISPR-based diagnostic technologies still require the incorporation of other amplification strategies (such as polymerase chain reaction) to improve the cis/trans cleavage activity of Cas12a, which complicates the detection workflow and lack of a uniform compatible system to respond to the target in one pot.<h3>Results</h3>To better fully-functioning CRISPR/Cas12a, we reported a novel technique for straightforward nucleic acid detection by incorporating enzyme-responsive steric hindrance-based branched inhibitors with CRISPR/AsCas12a methodology. The construction-transferable branched inhibitors coupled with a specific overhang flap induce spatial steric effects and result in the loss of the binding ability of Cas12a, which inhibits the activity of Cas12a. Target as the input signal would trigger the site-directed APE1 enzyme incision of the inhibitors, thus transforming the conformation of the inhibitors into split activators to illumine the CRISPR/AsCas12a catalyst system. At the same time, we found that APE1 could drive the enzymatic positive feedback circuit and exhibited considerably high amplification efficiency to enhance the detection ability of nucleic acids. Besides, our method provides universal platforms and can be realized in real-time and one-pot detection of HIV-1 DNA by replacing the inhibitors and crRNA with different target recognition sequences.<h3>Significance and Novelty</h3>Overall, due to the high programmability of the nucleic acid network, this work proposed a feasible way to use the steric hindrance-based inhibitors as a switchable element, decorating the CRISPR/Cas12a-based strategy equipment for molecular diagnostics. Besides, this strategy could offer a simple tool for detecting trace nucleic acid, which opens avenues for future clinical application.","PeriodicalId":240,"journal":{"name":"Analytica Chimica Acta","volume":"7 1","pages":""},"PeriodicalIF":6.2,"publicationDate":"2024-12-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142763032","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Selective colorimetric detection of carbosulfan based on its hydrolysis behavior and Ti3C2/AuPt nanozyme","authors":"Shuxian Dai, Mengting Hu, Wen Zhang, Zhen Lei","doi":"10.1016/j.aca.2024.343519","DOIUrl":"https://doi.org/10.1016/j.aca.2024.343519","url":null,"abstract":"<h3>Background</h3>Carbosulfan (CBS) is a widely used carbamate pesticide in agricultural production, its easy decomposition into hypertoxic carbofuran poses serious threats to human health and food safety. Therefore, sensitive and accurate detection of CBS is of significant importance. Conventional chromatography-based techniques require expensive instruments and complicated sample pretreatment, limiting their application for fast detection. Current electrochemical and colorimetric methods for detection of pesticides based on the cascade catalytic reactions between acetylcholinesterase (AChE) and nanozymes, which exhibit inferior selectivity. Hence, selective, sensitive and fast detection of CBS is still challenging.<h3>Results</h3>In this work, an AChE-free colorimetric method was proposed for selective detection of CBS based on its unique hydrolysis behavior and nanozyme. Ti₃C₂ nanosheets/AuPt nanoparticles (Ti₃C₂/AuPt NPs) with enhanced peroxidase-like activity were prepared via one-step self-reduction reaction. CBS can be hydrolyzed under acidic condition and produce -SH moieties, which could bond to Pt atoms of Ti₃C₂/AuPt NPs and shield the active sites of nanozyme, resulting in decreased catalytic activity. Based on the inhibitory effect on the peroxidase-like activity of Ti₃C₂/AuPt NPs, a colorimetric method was proposed for direct detection of CBS. Under optimal conditions, the method showed wide linear range (0.5 ng mL⁻¹-5 μg mL⁻¹), low limit of detection (0.342 nM), good selectivity and anti-interference ability. The feasibility of this method for practical use was confirmed by analysis of CBS in real lake water samples.<h3>Significance</h3>This work proposed a simple colorimetric method for selective and fast detection of CBS, which avoided employing AChE and cascade catalytic reactions, significantly lowering the detection cost and improving detection efficiency. The method showed great potential for accurate detection of CBS in actual samples, and provided a new avenue for developing nanozyme-based colorimetric method for detection of other pesticide residues.","PeriodicalId":240,"journal":{"name":"Analytica Chimica Acta","volume":"7 1","pages":""},"PeriodicalIF":6.2,"publicationDate":"2024-12-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142760748","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Magnetic relaxation switch biosensor for detection of Vibrio parahaemolyticus based on photocleavable hydrogel","authors":"Le Chen, Dongyu Zhang, Fan Yang, Xizhi Shi, Xiaohua Jiang, Tingting Hao, Qingqing Zhang, Yufang Hu, Sui Wang, Zhiyong Guo","doi":"10.1016/j.aca.2024.343516","DOIUrl":"https://doi.org/10.1016/j.aca.2024.343516","url":null,"abstract":"<h3>Background</h3>Foodborne pathogens, particularly <em>Vibrio parahaemolyticus</em> (VP) found in seafood, pose significant health risks, including abdominal pain, nausea, and even death. Rapid, accurate, and sensitive detection of these pathogens is crucial for food safety and public health. However, existing detection methods often require complex sample pretreatment, which limits their practical application. This study aims to overcome these limitations by developing a label-free magnetic relaxation switch (MRS) biosensor for the detection of VP, utilizing a photocleavable sol-gel phase transition system for improved efficiency and accuracy.<h3>Results</h3>In this work, a tag-free magnetic relaxation switch (MRS) biosensor was designed for the detection of <em>Vibrio parahaemolyticus</em> (VP), based on a photocleavable sol-gel phase transition system. A large amount of lithium acyl hypophosphite (LAP), gold nanoparticles (AuNPs), and single-stranded DNA (ssDNA) loaded on the surface of Ti₃C₂T_x MXene acted as the signal unit LAP-MXene@AuNPs-ssDNA. The pipette tip served as a reaction vessel, and when VP was present, Apt specifically captured VP and released the signal units. The released signal units were then injected into the low-field nuclear magnetic resonance (LF-NMR) test solution, a gel formed by crosslinking of disulfide bonds. The gel was cleaved by LAPs on the signal units under ultraviolet (UV) irradiation, triggering a gel-sol phase transition, which increased transverse relaxation time (T₂), thus enabling the detection of VP. Under the optimal experimental conditions, the linear range and detection limit for VP were 10² ∼ 10⁸ CFU/mL and 10 CFU/mL, respectively.<h3>Significance and Novelty</h3>The simplified biometric identification process in the pipette tip reduces errors from multiple sample transfers, enhancing efficiency. The use of photocleavable hydrogel for signal output eliminates issues associated with magnetic material aggregation, significantly improving detection precision. The assay is of good selectivity, stability reproducibility, and convenience, having a broad application prospect in the rapid detection of pathogenic bacteria in the field.","PeriodicalId":240,"journal":{"name":"Analytica Chimica Acta","volume":"204 1","pages":""},"PeriodicalIF":6.2,"publicationDate":"2024-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142760684","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development and Use of DJ-1 Affinity Microcolumns to Screen and Study Small Drug Candidates for Parkinson’s Disease","authors":"Jacob C. Jones, Jiusheng Lin, Sadia Sharmeen, Md Masudur Rahman, Ha H. Truong, Ting-Rong Chern, Mark A. Wilson, David S. Hage","doi":"10.1016/j.aca.2024.343520","DOIUrl":"https://doi.org/10.1016/j.aca.2024.343520","url":null,"abstract":"<h3>Background</h3>DJ-1 is a protein whose mutation causes rare heritable forms of Parkinson’s disease (PD) and is of interest as a target for treating PD and other disorders. This work used high performance affinity microcolumns to screen and examine the binding of small molecules to DJ-1, as could be used to develop new therapeutics or to study the role of DJ-1 in PD. Non-covalent entrapment was used to place microgram quantities of DJ-1 in an unmodified form within microcolumns, which were then used in multiple studies to analyze binding by model compounds and possible drug candidates to DJ-1.<h3>Results</h3>Several factors were examined in optimizing the entrapment method, including the addition of a reducing agent to maintain a reduced active site cysteine residue in DJ-1, the concentration of DJ-1 employed, and the entrapment times. Isatin was used as a known binding agent (dissociation constant, ∼2.0 μM) and probe for DJ-1 activity. This compound gave good retention on 2.0 cm × 2.1 mm inner diameter DJ-1 microcolumns made under the final entrapment conditions, with a typical retention factor of 14 and elution in ∼8 min at 0.50 mL/min. These DJ-1 microcolumns were used to evaluate the binding of small molecules that were selected <em>in silico</em> to bind or not to bind DJ-1. A compound predicted to have good binding with DJ-1 gave a retention factor of 122, an elution time of ∼15 min at 0.50 mL/min, and an estimated dissociation constant for this protein of 0.5 μM.<h3>Significance</h3>These chromatographic tools can be used in future work to screen additional possible binding agents for DJ-1 or adapted for examining drug candidates for other proteins. This work represents the first time protein entrapment has been deployed with DJ-1, and it is the first experimental confirmation of binding to DJ-1 by a small lead compound selected <em>in silico</em>.","PeriodicalId":240,"journal":{"name":"Analytica Chimica Acta","volume":"26 1","pages":""},"PeriodicalIF":6.2,"publicationDate":"2024-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142760682","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A simply synthesized, silver ions-doped porous gold microparticles-based SERS aptamer sensor for ultrasensitive and broad-range quantitative detection of IL-6","authors":"Bixia Liang, Zhixi Huang, Lingyan Cheng, Jin Quan, Zongxia Mou, Nan Li, Xin Cui","doi":"10.1016/j.aca.2024.343504","DOIUrl":"https://doi.org/10.1016/j.aca.2024.343504","url":null,"abstract":"<h3>Background</h3>The multifunctional cytokine interleukin-6 (IL-6) plays a pivotal role in chronic and acute inflammatory responses, underscoring the importance of accurately determining IL-6 levels for early diagnosis, prevention, and treatment of inflammation.<h3>Results</h3>This study developed a versatile and innovative single-particle surface-enhanced Raman spectroscopy (SERS) sensing platform for the precise and sensitive quantification of IL-6 in complex samples using a novel one-pot synthesized, silver ions-doped three-dimensional porous gold microparticles (PGMs) with abundant hot spots for robust SERS enhancement. By rationally designing rich cytosine-Ag⁺-cytosine base pairs between IL-6 aptamers and complementary chains on the PGMs, we harnessed the SERS-enhancing effect to achieve highly sensitive and specific IL-6 quantification within a wide range of 10^-9 to 10^-4 mg/mL and a limit of detection (LOD) of 0.093 pg/mL. Moreover, the accurate detection of IL-6 in spiked serum samples exhibited a remarkable recovery rate ranging from 97.2% and 107.6%.<h3>Significance</h3>This aptamer sensor provides an alternative tool for cost-effective, sensitive and broad-range IL-6 detection, which would contribute to the early detection of inflammation and pave the way for timely interventions and improved patient outcomes.","PeriodicalId":240,"journal":{"name":"Analytica Chimica Acta","volume":"200 1","pages":""},"PeriodicalIF":6.2,"publicationDate":"2024-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142753435","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Portable dual-function ratio-type triple-emission molecularly imprinted fluorescence sensor for the simultaneous visual detection of hepatitis A and B viruses","authors":"Hang Gong, Ganping Cai, Yong Li, Ning Jiang, Chunyan Chen, Feng Chen, Changqun Cai","doi":"10.1016/j.aca.2024.343451","DOIUrl":"https://doi.org/10.1016/j.aca.2024.343451","url":null,"abstract":"<h3>Background</h3>Viral epidemics have long endangered human health and had dramatic impacts on environment and society. The currently known viruses and the rapid emergence of previously unknown viruses lead to an urgent need for effective virus detection strategies. It is important to develop methods that can detect multiple related viruses simultaneously in order to improve detection efficiency and to avoid treatment delays due to misdiagnoses. However, an important practical problem for viruses simultaneously detection is mutual interference between the targets, which is caused by a certain degree of signal superposition.<h3>Results</h3>A portable ratio-based triple-emission molecular imprinting fluorescence sensor was constructed to detect hepatitis A virus (HAV) and hepatitis B virus (HBV) simultaneously, which eliminated background interference and mutual interference between the two targets, and improved detection accuracy. In this sensor, a layer containing blue fluorescent carbon quantum dots (B-CDs) coated with silicon was used as a constant luminescent core to permit ratiometric detection of signals, this layer also affords visual analysis due to its constant blue color. As signal sources to employ yellow-green and red quantum dots, HAV- and HBV-specific molecularly imprinted polymers (MIPs) were prepared by imprinting virus onto the core containing the B-CDs. Under the optimized detection conditions, the simply physically mixing HAV-MIPs and HBV-MIPs in a specific ratio, which leads to non-interfering fluorescence signals and the simultaneous detection of the two target viruses via the rich color visualization under ultraviolet light.<h3>Significance</h3>This strategy provides a simple and low-cost (0.26 ¥ /sensor) method for the simultaneous detection of two hepatitis viruses, and provides an avenue for the development of portable methods for the simultaneous detection of similar highly infectious viruses. This self-service sensor also has the potential to be used by patients themselves, reducing pressures on medical staff and decreasing risks of cross-infection.","PeriodicalId":240,"journal":{"name":"Analytica Chimica Acta","volume":"22 1","pages":""},"PeriodicalIF":6.2,"publicationDate":"2024-11-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142742684","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sample preparation using deep eutectic solvents in combination with nanomaterials in analytical procedures: a review","authors":"Ke Li, Jingyan Chen, Seulgi Kang, Jeongmi Lee","doi":"10.1016/j.aca.2024.343494","DOIUrl":"https://doi.org/10.1016/j.aca.2024.343494","url":null,"abstract":"<h3>Background</h3>Sample preparation can be a critical stage of analytical procedures that profoundly influences their performance, environmental impact, and overall efficiency. While nanomaterials have revolutionized sample preparation owing to their high surface area-to-volume ratios, tunable surface chemistry, and enhanced adsorption capacities, limitations persist. Researchers have ushered in a new era of efficient sample preparation methodologies that could overcome the limitations of nanomaterials by introducing deep eutectic solvents (DESs), which have unique advantages such as low volatility and toxicity, biodegradability, and tunability.<h3>Results</h3>This review comprehensively explores the integration of DESs into nanomaterials in sample preparation methods. The review begins with a brief review of the different types of sample preparation techniques where DESs in combination with nanomaterials are used, including solid-phase extraction, solid-phase microextraction, and liquid-phase microextraction. The review then delves into different classes of nanomaterials depending on the functions of the DESs, that is, the modifier of nanosorbent, desorption or extraction solvent from nanosorbents, and carrier liquid in nanofluid. It further examines the applications of those nanomaterials to the quantitative analysis of a wide range of analytes within complex matrices. Finally, several challenges and concerns are discussed, including the stability, sustainability, and environmental impact of the materials, as well as the design of task-specific DESs.<h3>Significance</h3>Unlike previous reviews on DESs used as extraction solvents, this work is the first review of the nanomaterials in which DESs with diverse roles are involved. While addressing the challenges is crucial, the advantages and opportunities offered by the DES-based nanomaterials warrant further investigation for future development in sample preparation.","PeriodicalId":240,"journal":{"name":"Analytica Chimica Acta","volume":"10 1","pages":""},"PeriodicalIF":6.2,"publicationDate":"2024-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142735537","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}