Analytica Chimica Acta最新文献

{"title":"Look but don't touch: Non-invasive chemical analysis of organic paint binders - A review.","authors":"Elena C L Rigante, Cosima D Calvano, Giovanni Ventura, Tommaso R I Cataldi","doi":"10.1016/j.aca.2024.343251","DOIUrl":"https://doi.org/10.1016/j.aca.2024.343251","url":null,"abstract":"<p><p>Diagnostics on historical art samples are decisive for assessing degradation and understanding the chemical composition of supports and polychromies. These investigations help us in uncovering the artist's style and techniques and provide invaluable information for restoration, preservation and conservation. In paint formulation, the binder, also known as medium, disperses insoluble pigments and creates a homogeneous, adhesive mixture. Various analytical techniques, often used in combination, are usually employed to characterize binders with infrared (IR) and Raman spectroscopies being the most common choices. Recently, mass spectrometry (MS) has gained prominence for its ability to allow detailed structural characterization and identification, thanks to soft ionization sources such as matrix-assisted laser desorption ionization (MALDI) and electrospray ionization (ESI). However, MS typically requires micro-sampling, which is often prohibited for highly valuable artworks. This limitation has driven research toward the development of innovative minimally invasive sampling strategies like enzyme-functionalized gels applied to polychromies for in-situ protein digestion and peptide extraction. These quasi-non-invasive methods offer powerful solutions for extracting and characterizing organic painting binders, unlocking valuable insights into these elusive materials. This review aims to explore both the most common non-invasive analytical techniques used to characterize ancient and contemporary painting binders, and the most recent advancements in minimally invasive sampling strategies, which represent convenient and interesting approaches to enable the use of invasive analytical approaches while preserving the integrity of precious artworks.</p>","PeriodicalId":240,"journal":{"name":"Analytica Chimica Acta","volume":"1335 ","pages":"343251"},"PeriodicalIF":5.7,"publicationDate":"2025-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142790719","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Review on activity-based detection of doping substances and growth promotors in biological matrices: do bioassays deserve a place in control programs?","authors":"Liesl K Janssens, Peter Van Eenoo, Christophe P Stove","doi":"10.1016/j.aca.2024.343244","DOIUrl":"https://doi.org/10.1016/j.aca.2024.343244","url":null,"abstract":"<p><strong>Background: </strong>Control programs such as anti-doping control and growth promotor residue surveillance programs are challenged by the emergence of designer drugs and the use of low-level drug cocktails. In order to cope with these challenges, the use of bioassays, measuring biological activity in a matrix, has been explored over the past two decades as a universal means to detect (combinations of) unknown drugs, regardless of their chemical structure.</p><p><strong>Results: </strong>This review compiles the experience on the use of activity-based assays to detect doping substances and growth promotors in biological matrices of humans (athletes) or live animals (race and/or food-producing animals). The aim is to learn from the scientific progress, going from initial research to the recent revival of this topic. Bioassay improvements and remaining limitations are discussed, along with a rational evaluation of possible applications of bioassays in control programs at their current functionality. Limitations include the possible interference by endogenous compounds and the challenge to detect metabolically activated (pro-)drugs. Nevertheless, successful validation of bioassays has been achieved, ensuring robust, reliable and valid results.</p><p><strong>Significance: </strong>We conclude by proposing three applications of bioassays that provide added-value to the current testing procedures: (i) characterization of compounds to provide indisputable proof of biological effects and to prioritize legislative (cf. expansion of bans) and research endeavors (cf. method development), (ii) bioassay-based screening of biological samples to direct intelligent sample storage, sample retesting and targeted athlete testing, (iii) bioassay-guided identification of drugs to overcome the challenges of suspicious peak selection, related to high-resolution techniques.</p>","PeriodicalId":240,"journal":{"name":"Analytica Chimica Acta","volume":"1334 ","pages":"343244"},"PeriodicalIF":5.7,"publicationDate":"2025-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142783671","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"High Resolving Power Electrospray Drift Tube Ion Mobility Spectrometer with Heated Desolvation Tube","authors":"Marc-Aurèle Boillat, Peter C. Hauser","doi":"10.1016/j.aca.2024.343574","DOIUrl":"https://doi.org/10.1016/j.aca.2024.343574","url":null,"abstract":"<h3>Background</h3>The separation performance of drift tube ion mobility spectrometers is usually relatively weak with resolving powers well below 100. Improving this aspect requires, besides the optimization of other parameters, the challenging increase of the drift voltage as deduced from fundamental equations describing the broadening of a drifting ion swarm. We recently succeeded in constructing an improved high voltage instrument equipped with an electrospray source capable of analysing liquid samples with resolving powers above 200. This instrument was further perfected with a newly developed heated desolvation tube guiding the ions to the injection gate. The electrospray desolvation process was thus enhanced while the separation region was maintained at room temperature to keep diffusional band broadening to a minimum. A further modification was also made to the detector circuitry in order to reduce its noise.<h3>Results</h3>To demonstrate the performance of the instrument several challenging ion mixtures, including two herbicides, a polymer mixture, and isomers of carnitine esters were successfully separated and detected. The resolving powers, calculated from the arrival time and peak width at half height, ranged from 123 to 228. The latter value represents 96% of the theoretically achievable resolving power at the working drift voltage of 24.1 kV.<h3>Significance</h3>Stand-alone electrospray ion mobility spectrometry is not often used and has not yet been developed to its full potential. The results with improved resolving powers demonstrate its capability as a simple technique for the analysis of liquid samples, which may often serve as a lower cost alternative to chromatography or mass spectrometry.","PeriodicalId":240,"journal":{"name":"Analytica Chimica Acta","volume":"78 1","pages":""},"PeriodicalIF":6.2,"publicationDate":"2024-12-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142867350","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Entropy driven-based catalytic biosensors for bioanalysis: From construction to application-A review","authors":"Sha Yang, Xinyu Zhan, Lijia Yuan, Marc Lamy de la Chapelle, Weiling Fu, Xiang Yang","doi":"10.1016/j.aca.2024.343549","DOIUrl":"https://doi.org/10.1016/j.aca.2024.343549","url":null,"abstract":"The rapid advancement of precision medicine and the continuous emergence of novel pathogens have presented new challenges for biosensors, necessitating higher requirements. Target amplification technology serves as the core component in biosensor construction. Enzyme-based amplification methods are often sensitive and selective but involve relatively complex operational steps, whereas enzyme-free amplification methods offer simplicity but frequently fail to meet both sensitivity and selectivity simultaneously. Existing research has confirmed that entropy-driven catalyst (EDC) biosensors not only fulfills the demands for sensitivity and selectivity concurrently but also offers ease of operation and flexibility in construction. In this review, we summarize the key advantages of EDC, explore how to construct DNA nanomachines based on these advantages to achieve intracellular detection and simultaneous detection of multiple targets, as well as point-of-care testing (POCT) to address practical issues in clinical diagnosis and treatment. We also anticipate potential challenges, propose corresponding solutions, and outline future development directions for EDC-based biosensors in practical clinical applications. We firmly believe that EDC sensors will emerge as a crucial branch within the realm of biosensor development.","PeriodicalId":240,"journal":{"name":"Analytica Chimica Acta","volume":"1 1","pages":""},"PeriodicalIF":6.2,"publicationDate":"2024-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142857952","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Carbon dot embedded hybrid microgel from synthesis to sensing: Experimental and theoretical approach","authors":"Neha Garg, Ankita Garg, Aman Bhalla, Savita Chaudhary, Abhijit Dan","doi":"10.1016/j.aca.2024.343575","DOIUrl":"https://doi.org/10.1016/j.aca.2024.343575","url":null,"abstract":"<h3>Background</h3>The intellectual progress in fabricating artificial probes for selective appraisal of biologically admissible amino acids has displayed exponential growth in recent era.<h3>Results</h3>Herein, we apprehend the realistic sensing performance of a sulfonamidecinnamaldehyde based Schiff’s base i.e. N-(phenylallylbenzylidene)-4- methylbenzenesulfonohydrazide PBMBS with a customized design to trigger synergistic impact with an effective functional site. PBMBS has an effective fluorescence enhancement aptitude towards tryptophan (Trp) with a detection limit of 5.7 nM. The optimized water/solvent system with a suitable pH range for the quantitative determination of Trp has also been assessed. The fluorescence quantum yields of PBMBS displayed a 31% enhancement in the presence of Trp. <strong>Significance</strong>:PBMBS based fluorophore was successfully employed to enumerate the Trp content in different water samples with effective recoveries ranging from 97.8% to 104.6%. The effective interpretation of the molecular logic gate framework of PBMBS in the presence of Trp supports the potential prospects of the developed sensor in practical applications.","PeriodicalId":240,"journal":{"name":"Analytica Chimica Acta","volume":"15 6 1","pages":""},"PeriodicalIF":6.2,"publicationDate":"2024-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142857951","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Trans-dimensional Nanocoral Gold Foam Interfaces Affords Ultrasensitive Detection of Influenza Virus","authors":"Qingcui Wang, Biru Yang, Yaqi Zhu, Jiameng Pei, Lina Tang, Xiaohua Chen, Guo-Jun Zhang, Yu-Tao Li","doi":"10.1016/j.aca.2024.343576","DOIUrl":"https://doi.org/10.1016/j.aca.2024.343576","url":null,"abstract":"Development of sensitive and cost-effective strategies for detecting influenza viruses is crucial to combat the spread of infectious diseases. In this study, a novel trans-dimensional nanocoral gold foam (NCGF) was fabricated on screen-printed carbon electrodes using hydrogen template electrodeposition method. This unique structure, with interconnected large and small pores, significantly increased the specific surface area and stability of the sensor. Based on this nanostructure, the antibodies were further modified and used for influenza A viruses (IAVs) detection by enzyme-linked immunoelectrochemical method. The combination of the large specific surface area of NCGF and the catalytic reaction of alkaline phosphatase led to a dual amplification of electrochemical signals, enabling ultra-sensitive detection of IAVs. The NCGF-based biosensor demonstrated exceptional stability, sensitivity, and achieved a reliable limit of detection as low as 13.14 fg/mL, which is several orders of magnitude improvement in sensitivity over conventional electrochemical immunosensor. Furthermore, 72 clinical samples were analyzed using a portable detection device that could directly read signals from a mobile phone, and the results correlated well with gold standard PCR method. Overall, this rapid, sensitive, and portable assay provides a valuable option for early viral infection diagnosis.","PeriodicalId":240,"journal":{"name":"Analytica Chimica Acta","volume":"39 1","pages":""},"PeriodicalIF":6.2,"publicationDate":"2024-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142867348","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Innovative Separation of Melittin from Bee Venom Using Micro-Free-Flow Electrophoresis: An Experimental and Theoretical Study","authors":"Azadeh Kordzadeh, Ahmad Ramazani SA, Shohreh Mashayekhan","doi":"10.1016/j.aca.2024.343572","DOIUrl":"https://doi.org/10.1016/j.aca.2024.343572","url":null,"abstract":"<h3>Background</h3>Bee venom consists of more than 50% melittin (MLT), which has anti-cancer, anti-inflammatory, and antimicrobial properties. Bee venom also contains toxic components such as phospholipase A2 (PLA2) and hyaluronidase (HYA), which cause allergic reactions, so the toxic components must be removed to use MLT. In previous studies, analytical methods were used to separate MLT. This study used micro-free flow electrophoresis (μFFE) for MLT separation. This separation was simulated using computational fluid dynamics (CFD) and molecular dynamics simulation (MD). The glass chip was fabricated using the wet etched method, and MLT separation was investigated experimentally.<h3>Results</h3>The CFD results demonstrated that MLT was separated from PLA2 and HYA in less than 3 minutes, and MLT and toxic components took different paths in the channel. The operating conditions, such as the sample flow rate, buffer flow rate, electric field strength, and channel dimensions, were optimized during the simulation. The MD results showed that MLT's conformation does not change the separation process. MD simulation with an atomistic resolution could give us more accurate results of molecular interactions. Also, MLT separation was performed on a glass chip, adding to the precision of the process. The channel outputs were analyzed using high-performance liquid chromatography (HPLC). MLT separation using μFFE was performed for the first time. The results indicated that melittin was purified 90% in this separation, and PLA2 was rejected by 90%.<h3>Significance</h3>The results indicated that, for the first time, the separation of MLT from bee venom using μFFE could be achieved with a high recovery rate, thereby demonstrating its potential for biological applications. This separation in less than 3 minutes has higher yield and purity than analytical methods such as HPLC<strong>.</strong>","PeriodicalId":240,"journal":{"name":"Analytica Chimica Acta","volume":"41 1","pages":""},"PeriodicalIF":6.2,"publicationDate":"2024-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142857953","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Determination of alkali metal elements in solid biomass fuel by laser-induced breakdown spectroscopy: analysis and reduction of chemical matrix effects","authors":"Chengjun Li, Zhimin Lu, Jinzheng Chen, Ziyu Yu, Qi Yang, Huaiqing Qin, Xiwen Xing, Qingxiang Ma, Shunchun Yao","doi":"10.1016/j.aca.2024.343568","DOIUrl":"https://doi.org/10.1016/j.aca.2024.343568","url":null,"abstract":"<h3>Background</h3>Rapid and accurate detection of the biomass potassium (K) content in biomass is crucial for mitigating ash deposition and fouling issues in biomass fuel combustion processes. Laser-induced breakdown spectroscopy (LIBS) offers a promising approach for rapid analysis of biomass elemental. However, the accuracy of LIBS detection is susceptible to chemical matrix effects. Particularly in the case of biomass, characterized by its complex composition, the absence of pertinent studies on effect mechanisms impedes the enhancement of analytical accuracy.<h3>Results</h3>In this study, we investigated and compared two types of matrix effects related to chemical properties in biomass samples (analyte forms and matrix composition). Firstly, the inconsistency of K spectral response among different chemical properties samples and the performance of univariate models were analyzed. The results indicate that, compared to the chemical forms, differences in composition are the dominant factor of chemical matrix effects. Moreover, the compositional content of biomass samples is analyzed to correlate the matrix effect in LIBS measurements to a chemical property of the specimen. It is indicated that differences in volatile and ash content may lead to variations in the plasma excitation process, resulting in distinct spectra. Finally, a knowledge-based regression approach was employed to attenuate chemical matrix effects, the main influencing factors identified were analyzed as a priori knowledge for variable selection and inputting them into a partial least squares model. And 13 real solid biomass fuels were measured, resulting in root mean square error of prediction (RMSEP), R^2, and average standard deviation (ASD) of 0.99, 0.050%, and 0.001%, respectively.<h3>Significance</h3>This study investigated the influence of matrix effects related to biomass chemical properties on LIBS measurements, achieving rapid measurement of K. It promotes the application of LIBS in solid fuels and provides a methodological reference for LIBS analysis of complex matrix materials.","PeriodicalId":240,"journal":{"name":"Analytica Chimica Acta","volume":"10 1","pages":""},"PeriodicalIF":6.2,"publicationDate":"2024-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142848944","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Medium entropy-derived flower-like FeCeCu nanozyme with excellent oxidase-like activity for on-site and visual detection of carbosulfan","authors":"Wanning Li, Taimei Cai, Jianwen Tian, Yaru Dong, Fuqiang Hu, Hailong Peng","doi":"10.1016/j.aca.2024.343566","DOIUrl":"https://doi.org/10.1016/j.aca.2024.343566","url":null,"abstract":"<h3>Background</h3>Carbosulfan residues in environment is very harmful to human health. The rapid and high sensitive detection of carbosulfan residues is particularly important to guarantee human health and safety. The conventional chromatographic techniques and enzyme inhibition strategies cannot realize on-site and visual detection of carbosulfan. It is clear that a novel nanozyme-based method was need, which exhibited advantages in low-cost, rapidity, and portability with easy-to-use operation.<h3>Results</h3>A medium entropy-derived flower-like FeCeCu nanozyme (FeCeCuzyme) were prepared via the metal-organic coordination method with “Ostwal ripening” growth process. FeCeCuzyme exhibited an excellent oxidase-like activity due to an abundant active sites in the flower-like structure. Carbosulfan can produce the sulfide compound by hydrolysis reaction under acidic condition, which could easily form sulfide-metal bonds with FeCeCuzyme, thereby significantly quenching their oxidase-like activity and hindering nanozyme-mediated chromogenic reaction. Given this phenomenon, the FeCeCuzyme were used as a colourimetric sensor for highly-specific carbosulfan detection without using acetylcholinesterase and H₂O₂. The FeCeCuzyme colourimetric sensor showed a wide linear range from 0.15 to 50.00 μM ( <em>R</em>² = 0.9970) with low detection limit of 0.13 μM. Meanwhile, FeCeCuzyme sensor was integrated with smartphone to design a portable detection platform, which realizes the on-site and rapid detection of carbosulfan with easy-to-operation. A low detection limit of 0.14 μM was obtained in the linear relation of 0.15 to 50.00 μM. The satisfactory recoveries (91.17%-108.00%) from the spiking method were highly agreed with HPLC technique, and which further verified the feasibility of FeCeCuzyme-based strategies in real samples.<h3>Significance and novelty</h3>This work provides a pioneer new avenue for design of novel nanozymes, and offers an efficient alternative to the conventional methods for specifical, fast, and on-sites detection of carbosulfan in environment.","PeriodicalId":240,"journal":{"name":"Analytica Chimica Acta","volume":"30 1","pages":""},"PeriodicalIF":6.2,"publicationDate":"2024-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142848943","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Microfluidic Fractionation of Microplastics, Bacteria and Microalgae with Induced-charge Electro-osmotic Eddies","authors":"Xiaoming Chen, Ziwei Gao, Jishun Shi, Yingxuan Liu, Zhipeng Song, Chungang Wu, Li Su, Zhouyang Zhang, Yong Zhao","doi":"10.1016/j.aca.2024.343569","DOIUrl":"https://doi.org/10.1016/j.aca.2024.343569","url":null,"abstract":"<h3>Background</h3>Fractionation of microalgal cells has important applications in producing pharmaceuticals and treating diseases. Multiple types of microalgal cells generally coexist in the oceans or lakes and are easily contaminated by microplastics and bacteria. Therefore, it is of paramount significance to develop an effective fractionation approach for microalgal cells for biological applications. Counter-rotating induced-charge electro-osmotic (ICEO) eddies present unique advantages in separating microalgal cells for flexible electrode extension fashion and profile regulation manner. Enthused by these, we proposed a contact-free microfluidic approach for the fractionation of microplastics, bacteria, and microalgae with extensible counter-rotating ICEO eddies.<h3>Results</h3>Firstly, we investigated the flow-field distribution actuated by counter-rotating ICEO eddies, the influence of working parameters on the fluid velocity, and the effect of particle sizes and charges on particle separation. Secondly, depending on the investigation of the movement of microparticles and microalgal cells, we explored synthetic effects of flow rate, voltage, and frequency on the fractionation of microalgal cells from microplastics with an efficiency of about 100%. Thirdly, this method was used to remove the bacteria for pure <em>Dunaliella salina</em> with a purity of about 95.24%. Fourthly, this approach was engineered in the fractionation of <em>Diatoms</em>, <em>Chlorella</em>, and <em>Dunaliella salina</em>, and the influence of voltage and frequency on the purity of microalgae was studied. Finally, we proposed a multi-stage separation of microalgal cells with extended counter-rotating ICEO eddies and obtained an efficiency of 91.00% in the first stage and a purity of 91.55% and 90.48% in the second stage.<h3>Significance</h3>This contact-free method holds good potential in the selection of target microalgal cells to address the tricky issues of chronic wound treatment with the advantage of flexible electrode extension fashion and profile regulation manner.","PeriodicalId":240,"journal":{"name":"Analytica Chimica Acta","volume":"193 1","pages":""},"PeriodicalIF":6.2,"publicationDate":"2024-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142857669","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}