Analytica Chimica Acta最新文献

{"title":"Unsupervised classification of iron ores based on elemental and isotopic signatures from atomic and molecular emissions of laser-induced plasma","authors":"Sung-Uk Choi, Sol-Chan Han, Jong-Il Yun","doi":"10.1016/j.aca.2025.344191","DOIUrl":"https://doi.org/10.1016/j.aca.2025.344191","url":null,"abstract":"<h3>Background</h3>Iron ore classification by grade and origin is critical for quality assurance in steel manufacturing. However, traditional analytical methods can be time-consuming and may not provide comprehensive information for accurate classification.<h3>Results</h3>The present study introduces a novel classification approach utilizing laser-induced breakdown spectroscopy (LIBS) to simultaneously discriminate iron ore grades (fine, lump, and concentrate) and origins (Australia, Brazil, and South Africa), without necessitating prior knowledge of the samples. A key aspect of this approach is to leverage multiple spectral features from laser-induced plasma: (i) atomic lines representing elemental composition, and (ii) molecular bands reflecting isotopic signatures. Based on this comprehensive spectral data, principal component analysis (PCA) was employed to visualize the correlations among the datasets, thereby illustrating how elemental composition and isotopic abundance correlate with grades and origins. Subsequently, the <em>k</em>-means clustering algorithm was utilized as an unsupervised classifier, eliminating the need for previously labeled training data. Consequently, the present approach could achieve an accuracy exceeding 94 % in determining the grade and origin of ores.<h3>Significance</h3>This study successfully established the rapid and versatile classification method for unknown iron ores, offering significant benefits for various industrial applications.","PeriodicalId":240,"journal":{"name":"Analytica Chimica Acta","volume":"130 1","pages":""},"PeriodicalIF":6.2,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144066494","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Biological Sample Desalting and Buffer Replacement Based on Electromigration in a Discontinuous Electrolyte System Using a 3D Printed Device","authors":"Vanda Kocianová, Ivona Voráčová, Yann Astier, Doo Soo Chung, František Foret","doi":"10.1016/j.aca.2025.344198","DOIUrl":"https://doi.org/10.1016/j.aca.2025.344198","url":null,"abstract":"<h3>Background</h3>The quality and yield of DNA specimens are essential for downstream analyses. Complex biological or environmental samples contain interfering compounds requiring advanced protocols for removing salts, small organic molecules, and/or proteins without compromising the DNA fragments distribution in the original sample. High-molecular-weight DNA fragments are often discriminated by standard extraction methods in attempts to remove the highly concentrated inorganic sample components.<h3>Results</h3>Here, we introduce a simple device for the simplification, purification, desalting, and buffer exchange of complex biological samples based on electrodialysis in discontinuous electrolyte systems. The device combines a 3D-printed body with two electrolyte reservoirs and commercially available cassettes with dialysis membranes as inserts. Upon applying an electric current via electrodes inside the electrolyte reservoirs, the sample ions, injected into the cassette or one of the electrolyte reservoirs, electromigrate across the dialysis membranes. During this process, small sample ions pass through the membrane and are substituted by the ions of the selected buffers loaded into the electrolyte reservoirs. The larger ions, such as DNA fragments or proteins, stay in the sample reservoir. The performance of the device was evaluated using DNA samples in blood plasma. Several milliliters of a plasma sample were purified in 30 min with 90% DNA recovery.<h3>Significance</h3>The device enables fast and effective purification of highly complicated samples. It can be easily scaled for the available sample amount (ranging from microliters to milliliters) and the analyte size of interest by selecting appropriate membrane pore sizes. The device's applicability was optimized on DNA samples with high salt content and tested on plasma samples. But it also has the potential for purification/desalting of a wide range of biological compounds, including proteins, peptides, or charged oligosaccharides, as well as organelles, cells, viruses, or bacteria.","PeriodicalId":240,"journal":{"name":"Analytica Chimica Acta","volume":"30 1","pages":""},"PeriodicalIF":6.2,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144066490","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advancing NMR-based quantification in complex mixtures using fourier transform and complete reduction to amplitude frequency table - The case of sugars","authors":"Jennifer Janovick ,&nbsp;Krish Krishnamurthy ,&nbsp;Peter Howard ,&nbsp;Emmanuel Hatzakis","doi":"10.1016/j.aca.2025.344173","DOIUrl":"10.1016/j.aca.2025.344173","url":null,"abstract":"<div><h3>Background</h3><div>Sugars are building blocks of polysaccharides, and they are involved in many food and biotechnological applications. However, current methods of analysis have several limitations, preventing our understanding about their functions and roles in different systems, such as biological mixtures. Thus, there is a constant need for analytical methods that allow their rigorous and convenient quantification. NMR-based methodologies have a great potential in sugar analysis, however the traditional Fourier transform approach is associated with significant challenges related to sensitivity, resolution and error prone processing steps.</div></div><div><h3>Results</h3><div>A “clean” and straightforward ¹³C-detected NMR method for sugar analysis was developed. Nine sugars commonly found as building blocks of polysaccharides were analyzed with ¹H and ¹³C NMR with the later found to be more effective due to the complexity of the mixtures. Minor tautomers were also identified and found to appear in relatively significant amounts in some cases. In addition to the traditional Fourier transform, integration-based approaches, CRAFT-based analysis was assessed for the quantification of sugars in a complex mixture. CRAFT utilizing Bayesian analysis was found to generate high quality and repeatable results in an automated and less error-prone manner. Finally, CRAFT allows for significant improvement in spectral resolution of the 2D HSQC, thus rendering the NMR assignment much more convenient, even for less experience users.</div></div><div><h3>Significance</h3><div>This novel and systematic study for the quantification of sugars in complex mixtures with Fourier transform and CRAFT, will advance our capabilities for sugar quantification. It is also expected to lay the groundwork for the application of time-domain NMR data for targeted analysis and can be extended to other matrices.</div></div>","PeriodicalId":240,"journal":{"name":"Analytica Chimica Acta","volume":"1363 ","pages":"Article 344173"},"PeriodicalIF":5.7,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143979966","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mercapto-β-cyclodextrin grafting uniform spherical covalent organic frameworks for enantioseparation in liquid chromatography","authors":"Huizhen Ni,&nbsp;Wentao Xu,&nbsp;Linna Xu,&nbsp;Songlin Chen,&nbsp;Junchao Zhu,&nbsp;Shengqiang Tong","doi":"10.1016/j.aca.2025.344186","DOIUrl":"10.1016/j.aca.2025.344186","url":null,"abstract":"<div><div>Despite the extensive development of covalent organic frameworks (COFs) as stationary phases for chromatography, the majority of COF-based stationary phases require application by bonding or coating on silica gel due to their irregular morphology, nanoscale particle size and broad particle size distribution, which limits the utilization of COFs in liquid chromatography. To take full advantage of COFs, we synthesized size-controllable spherical COFs (SCOFs) as stationary phases further functionalized by mercapto-<em>β</em>-cyclodextrin (SCOFs@CD). The direct-packed SCOFs-1.5μm column achieved separations of small molecules including monosubstituted aromatics, polycyclic aromatic hydrocarbons, and alkylbenzenes, which showed better column efficiency than the SCOFs-2.0μm column. Furthermore, the <span><span>SCOFs-1.5μm@CD</span><svg><path></path></svg></span> successfully separated dansulfonyl derivatized branched-chain amino acids (DNS-BCAAs) in HILIC mode. This research expanded the application of SCOFs stationary phases and demonstrated their significant potential in liquid chromatography.</div></div>","PeriodicalId":240,"journal":{"name":"Analytica Chimica Acta","volume":"1363 ","pages":"Article 344186"},"PeriodicalIF":5.7,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143945787","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Boric acid-functionalized PANI-ABA/PA hydrogel-based flexible pH sensor for real-time sweat monitoring","authors":"Meihui Gao ,&nbsp;Xianjing Zhang ,&nbsp;Shiqi Li ,&nbsp;He Gao ,&nbsp;Xinyu Li ,&nbsp;Dongyuan Xu ,&nbsp;Longbin Xu","doi":"10.1016/j.aca.2025.344188","DOIUrl":"10.1016/j.aca.2025.344188","url":null,"abstract":"<div><h3>Background</h3><div>Wearable pH sensors have emerged as promising tools for real-time health monitoring, particularly for sports and clinical applications, due to their ability to monitor key physiological indicators such as sweat pH. Sweat analysis provides valuable insights into metabolic processes and physical exertion. However, the development of flexible, stable, and highly sensitive sensors for accurate sweat pH detection remains a challenge. Conductive polymer such as polyaniline (PANI), have gained attention due to their unique properties, but further improvements in mechanical flexibility and sensor performance are needed to fully realize their potential for wearable biosensing applications.</div></div><div><h3>Results</h3><div>We present a boric acid-functionalized PANI-ABA/PA hydrogel, synthesized via electrochemical deposition, where boric acid plays a crucial role in crosslinking the rigid PANI material into a flexible, porous grid structure. This crosslinking improves the mechanical properties of the hydrogel while enhancing its ion-exchange capacity, leading to greater sensitivity and selectivity for H⁺ ions. PANI-ABA/PA hydrogel exhibits super-Nernstian behavior (77.80 mV pH⁻¹) across the physiological pH range (3.00–10.00), with rapid response times, minimal temperature drift, and excellent repeatability. Moreover, the hydrogel exhibits outstanding antifouling properties, ensuring consistent performance even in dynamic environments. Real-time human subject testing confirms the sensor's ability to accurately monitor sweat pH during physical activity, providing reliable and real-time data. These results highlight the promising potential of the PANI-based hydrogel for wearable biosensors in health monitoring.</div></div><div><h3>Significance and novelty</h3><div>This study highlights the role of boric acid in facilitating the formation of a crosslinked PANI-based grid structure, which improves the sensor's performance in wearable applications. Enhanced sensitivity, stability, and mechanical flexibility make this smart wearable sensor a promising candidate for continuous, non-invasive health monitoring. It opens new opportunities for real-time athletic performance tracking, personalized healthcare, and disease diagnostics, positioning it as a leading technology for future wearable health-monitoring systems.</div></div>","PeriodicalId":240,"journal":{"name":"Analytica Chimica Acta","volume":"1362 ","pages":"Article 344188"},"PeriodicalIF":5.7,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143946045","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sensitive detection of boron-containing drug delanzomib by a luminescence probe in health-related samples","authors":"Shaozhen Jing, Xiaolei Wu, Xueliang Wang, Daniel Shiu-Hin Chan, Tsun-Yin Li, Chun-Yuen Wong, Chung-Hang Leung, Wanhe Wang, Jing Wang","doi":"10.1016/j.aca.2025.344199","DOIUrl":"https://doi.org/10.1016/j.aca.2025.344199","url":null,"abstract":"<h3>Background</h3>Boron-containing drugs are widely used in anti-inflammatory, anti-bacterial, anti-tumor and other applications, thus it is important to develop methods for their detection. However, the sensitive detection of delanzomib through its boronic group remains challenging because of steric hindrance and interference from its own fluorescence.<h3>Results</h3>We report an iridium(III) complex containing the 1,2-dione group for the detection of delanzomib for the first time. The complex shows significantly decreased luminescence at 580 nm upon addition of delanzomib in aqueous solution. Complex <strong>1</strong> has good selectivity and sensitivity for delanzomib with a linear relationship in the range of 1 – 30 μM and a limit of detection (LOD) of 0.628 μM and a limit of quantification (LOQ) of 1 μM. Furthermore, complex <strong>1</strong> is successfully applied for the monitoring of delanzomib in health-related samples.<h3>Significance</h3>This study provides a solid basis for the advancement of analytical tools for the monitoring of boron-containing drugs.","PeriodicalId":240,"journal":{"name":"Analytica Chimica Acta","volume":"55 1","pages":""},"PeriodicalIF":6.2,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143979967","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Quantitative measurement method of equivalence ratio based on temperature characterization in actual methane-air premixed flame","authors":"Kaikai Kou ,&nbsp;Jianxun Ji ,&nbsp;Seher Saleem ,&nbsp;Weiran Song ,&nbsp;Zongyu Hou ,&nbsp;Weilli Yao ,&nbsp;Xiang Yu ,&nbsp;Zhe Wang","doi":"10.1016/j.aca.2025.344189","DOIUrl":"10.1016/j.aca.2025.344189","url":null,"abstract":"<div><h3>Background</h3><div>Laser-induced breakdown spectroscopy (LIBS) has emerged as a powerful technique for equivalence ratio measurement, offering deeper insight into chemical reaction processes in combustion systems. However, in practical flame conditions, variations in the equivalence ratio are inherently coupled with variations in local gas temperature, which significantly affect the accuracy of LIBS measurements by altering spectral line intensity ratios.</div></div><div><h3>Results</h3><div>To mitigate the impact of local gas temperature, a hybrid correction method comprising two key steps is proposed. First, plasma-based reference signals are exploited to accurately characterize local gas temperature and correct the spectral line intensities accordingly. Second, the modified spectrum standardization method is applied to compensate for deviations in spectral line ratios. This approach significantly reduces deviations in line intensity ratios across different gas temperatures. Specifically, the AS_RSD of H/O ratio decreases from 25.96 % to 3.94 %. The H/O ratio measured at different flame positions can be regressed onto a unified calibration curve, with an R² greater than 0.95. The robustness of the method is demonstrated on various line ratio pairs, such as H/O, C/O, H/N and C/N. This calibration model enables precise equivalence ratio determination throughout the entire flame field.</div></div><div><h3>Significance</h3><div>The hybrid correction method allows for the simultaneous and accurate measurement of both local gas temperature and equivalence ratio. By effectively mitigating the influence of temperature variations, this method represents a great progress in enhancing the accuracy of LIBS for equivalence ratio measurement in complex combustion environments.</div></div>","PeriodicalId":240,"journal":{"name":"Analytica Chimica Acta","volume":"1363 ","pages":"Article 344189"},"PeriodicalIF":5.7,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143945783","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dual-stage matrix elimination-ICP-MS methodology for REEs profiling in barite-associated ores","authors":"Xue-lin Dong ,&nbsp;Jun-han Liu ,&nbsp;Zheng-xun Jia ,&nbsp;Shao-zhan Tang ,&nbsp;Shuo-yun Tong ,&nbsp;Yu-xiang Xiong ,&nbsp;Lei Ouyang","doi":"10.1016/j.aca.2025.344195","DOIUrl":"10.1016/j.aca.2025.344195","url":null,"abstract":"<div><h3>Background</h3><div>The quantification of rare earth elements (REEs) in barite-associated geological samples is complicated by persistent matrix effects from coexisting elements and overlapping mass spectral interferences. These analytical challenges are particularly pronounced in samples containing high concentrations of light REEs (LREEs), which induce spectral overlaps on heavy REEs (HREEs) during inductively coupled plasma mass spectrometry (ICP-MS) measurements.</div></div><div><h3>Results</h3><div>A two-stage precipitation protocol achieved separation efficiencies exceeding 93.0 % for nine matrix elements (Ba, Na, Sr, etc.), while subsequent 717-type anionic resin chromatography enabled group separation of REEs. Sequential elution with methanol-nitric acid (3.40 mol/L, 7:3 v/v) and 0.20 mol/L nitric acid solutions yielded distinct recovery profiles: HREEs (Eu–Lu) showed &gt;90.0 % recovery in the first elution phase, followed by quantitative isolation of LREEs (La, Ce, Pr) in the second phase. The method was verified by using certified reference materials (GBW07892, GBW07893), and the determination results were consistent with the certified values. The application to three natural barite-associated REE ores was also realized.</div></div><div><h3>Significance</h3><div>This methodology resolves critical limitations in REE analysis through matrix element elimination and controlled LREE/HREE fractionation. The demonstrated 90.2–106.9 % recovery range across all REEs confirms operational robustness, while successful implementation in certified materials and field samples establishes reliability for geochemical characterization. The elution sequence optimization provides a template for analyzing REEs in barite-associated ores.</div></div>","PeriodicalId":240,"journal":{"name":"Analytica Chimica Acta","volume":"1363 ","pages":"Article 344195"},"PeriodicalIF":5.7,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143979939","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ultrasensitive detection of glutathione using CNs@Cr/g-C3N4 nanocomposite electrochemiluminescence in the presence of Cu2+","authors":"Hui Zhang,&nbsp;Ziqi Wang,&nbsp;Yahui Ji,&nbsp;Feifei Chen,&nbsp;Fei Wang,&nbsp;Gen Liu","doi":"10.1016/j.aca.2025.344194","DOIUrl":"10.1016/j.aca.2025.344194","url":null,"abstract":"<div><h3>Background</h3><div>Glutathione (GSH) serves as a pivotal antioxidant within biological systems. Dysregulated GSH levels are associated with a spectrum of pathologies, including carcinogenesis, hepatic dysfunction, and neurodegenerative disorders. Developing robust GSH detection methodologies is essential for assessing cellular health, facilitating early diagnosis of disease states, and tracking therapeutic efficacy. Electrochemiluminescence (ECL), which integrates electrochemical reactions with luminescent output, offers low background noise, making it highly suitable for biomolecule analysis. ECL-based GSH assays employing advanced nanomaterials are anticipated to amplify signals at low GSH concentrations, thereby playing a critical role in clinical diagnostics and biochemical research.</div></div><div><h3>Results</h3><div>This study presents a novel ECL sensor for the ultrasensitive detection of GSH, utilizing chromium/g–C₃N₄–loaded carbon nanospheres (CNs@Cr/g-C₃N₄) composites. Carbon spheres (CNs) and chromium (Cr) can improve the ECL properties of g-C₃N₄. However, the ECL signal of CNs@Cr/g-C₃N₄ is quenched (off-state) due to complex formation with Cu²⁺. Upon GSH addition, the higher coordination affinity between GSH and Cu²⁺ partially restores the ECL signal of g-C₃N₄ (on-state), allowing for quantitative GSH detection. Under optimized conditions, the linear detection range for GSH extends from 5.0 × 10⁻⁹ to 1.0 × 10⁻⁴ M with a limit of detection (LOD) of 3.3 × 10⁻¹⁰ M (S/N = 3), alongside high selectivity, stability, and reproducibility. More notably, the as-proposed ECL sensor was successfully applied to the quantification of GSH in real drug samples with excellent recovery rates.</div></div><div><h3>Signifiance</h3><div>In contrast to traditional techniques for GSH detection, our approach involves a one-time chemical modification of the electrode, eliminating the need for complex probe immobilization steps and streamlining the detection process. Besides, this “off-on” ECL sensing strategy, leveraging Cu²⁺ and CNs@Cr/g-C₃N₄, offers an innovative approach for developing advanced sensing systems. And this method is user-friendly, cost-effective, holding significant potential for applications in clinical diagnostics and pharmaceutical analysis.</div></div>","PeriodicalId":240,"journal":{"name":"Analytica Chimica Acta","volume":"1363 ","pages":"Article 344194"},"PeriodicalIF":5.7,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143945788","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Polymeric photonic crystal platform for organic amines detection based on enzyme inhibition","authors":"Lu Li ,&nbsp;Saibo Liang ,&nbsp;Juan Wei ,&nbsp;Yilong Li ,&nbsp;Xinyan Chen ,&nbsp;Chaoran Lei ,&nbsp;Guiqiang Fei","doi":"10.1016/j.aca.2025.344200","DOIUrl":"10.1016/j.aca.2025.344200","url":null,"abstract":"<div><h3>Background</h3><div>The extensive use of organic amines in industries has led to significant environmental concerns. Traditional detection methods, such as chromatography, are highly accurate but costly, time-consuming, and require specialized equipment, limiting their practical use in routine environmental monitoring. This underscores the need for portable, cost-effective, and user-friendly detection technologies.</div></div><div><h3>Results</h3><div>In this study, a novel sensor for organic amine detection based on inverse opal polymer photonic crystals (IOPPCs) has been facile designed and fabricated. By integrating urease-catalyzed reactions, the IOPPCs exhibited notable structural color changes in response to different amine solutions. Since the urease-catalyzed hydrolysis of urea directly affects the pH of the environment, the IOPPCs with a large surface area exhibit redshifted reflection peaks, enabling enhanced qualitative and semi-quantitative detection of organic amines. Notably, selective detection of ethylenediamine has been achieved at the low concentration from 1 × 10⁻⁹ mol L⁻¹ to 1 × 10⁻⁷ mol L⁻¹. To enhance user accessibility, the platform incorporates an existing mobile app to convert the structural color data into quantitative information.</div></div><div><h3>Significance and novelty</h3><div>The sensor platform demonstrates excellent resistance to interference, strong applicability, and reusability, highlighting its potential for real-time, on-site detection of organic amines. This has significant practical implications for environmental and public health monitoring.</div></div>","PeriodicalId":240,"journal":{"name":"Analytica Chimica Acta","volume":"1363 ","pages":"Article 344200"},"PeriodicalIF":5.7,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143979938","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}