World Journal of Surgical Oncology最新文献

{"title":"Refining distant metastasis stage in oral squamous cell carcinoma.","authors":"Xiaodong Sun, Qigen Fang, Junhui Yuan, Xu Zhang, Liyuan Dai, Fei Liu, Lisong Lin, Hui Zhao","doi":"10.1186/s12957-025-03852-9","DOIUrl":"10.1186/s12957-025-03852-9","url":null,"abstract":"<p><strong>Background: </strong>This study aimed to investigate the impact of varying distant metastatic burdens on prognosis in oral squamous cell carcinoma (OSCC) and to propose a novel staging system for distant metastasis.</p><p><strong>Methods: </strong>We retrospectively enrolled patients with primary stage IVc OSCC at diagnosis or those who developed confirmed distant metastasis within six months after curative treatment. These patients were divided into training and validation cohorts. The prognostic accuracy of the 8th edition AJCC staging system and our proposed staging system was evaluated based on overall survival (OS).</p><p><strong>Results: </strong>Among the 586 patients analyzed, 317 were assigned to the training cohort. OS was significantly influenced by the number of metastatic foci and the number of affected anatomic sites, but not by the size of the metastatic foci. Compared to stage IVc1 (defined as ≤ 3 metastatic foci within a single anatomic site), stage IVc2 (4-5 metastatic foci in one site or 2-5 foci across two sites) and stage IVc3 (all other distant metastasis patterns) were associated with hazard ratios of 1.35 (95% CI: 1.10-1.47) and 1.87 (95% CI: 1.51-2.43), respectively. Our proposed model achieved a concordance index of 0.691 and a likelihood ratio of 0.507, demonstrating superior discriminatory ability between patient subgroups and better homogeneity within subgroups compared to the AJCC system. Additionally, the new staging system remained an independent prognostic factor in the validation cohort.</p><p><strong>Conclusions: </strong>In primary stage IVc OSCC, the extent of distant metastatic burden significantly affects OS. Our novel staging system offers more precise prognostic stratification than the current AJCC classification. However, further validation through prospective studies is warranted.</p>","PeriodicalId":23856,"journal":{"name":"World Journal of Surgical Oncology","volume":"23 1","pages":"214"},"PeriodicalIF":2.5,"publicationDate":"2025-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12131364/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144217107","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Two pediatric patients with secondary glioblastoma following radiotherapy for acute lymphoblastic leukemia: a case report.","authors":"Nanae Chiba, Noriyoshi Takahashi, Hiroaki Ogawa, Takaya Yamamoto, Rei Umezawa, Masayuki Kanamori, Hidenori Endo, Keiichi Jingu","doi":"10.1186/s12957-025-03858-3","DOIUrl":"10.1186/s12957-025-03858-3","url":null,"abstract":"<p><strong>Background: </strong>Although radiation therapy (RT) has been established as a leading treatment for cancer patients, alongside surgery and chemotherapy, radiation itself is a well-known risk factor for carcinogenesis (Kamran et al., Cancer. 122(12):1809-21, 2016). A second malignant neoplasm may occur even with a small radiation dose (Diallo et al., Int J Radiat Oncol, 74(3):876-83, 2009). Relling et al. estimated that the cumulative risk of the development of malignant brain tumors following prophylactic cranial RT for acute lymphoblastic leukemia (ALL) patients is around 0.5%-1.5% at 15 years (Walter et al., J Clin Oncol Off J Am Soc Clin Oncol, 16(12):3761-7, 1998). The most frequent tumor types of radiation-induced malignant brain tumors are meningioma, glioblastoma (GBM), and sarcoma (Onishi et al., 2024). GBM--the most aggressive type of glioma--is classified as a high-grade glioma as per the WHO classification of tumors (Holland, Proc Natl Acad Sci U S A 97(12):6242-4, 2000; Louis et al., Neuro-Oncol 23(8):1231-51, 2021). GBM still draws attention due to its poor prognosis. The median overall survival (OS) of adult patients with GBM is approximately 12 months, and less than 5% of the patients might survive more than 5 years (Hertler et al., Eur J Cancer 189:112,913, 2023). Whereas the definitive treatment for GBM patients is surgery, adjuvant RT, and chemotherapy, the appropriate re-irradiation dose for patients with radiation-induced GBM (RIGBM) is still controversial since a more critical decision on the radiation dose needs to be made considering that the incidence of brain necrosis increases as the radiation dose increases (Lawrence et al., Int J Radiat Oncol 76(3):S20-7, 2010).</p><p><strong>Case presentation: </strong>Two patients at the age of 15 years were found to have RIGBM. The stable health duration until they developed RIGBM was 9-11 years after the first RT for ALL. Total resection was performed in Case 1 and a biopsy was first performed in Case 2 and then total resection was performed. Concurrent chemotherapy and external beam RT (50 Gy in 25 fractions for 5 weeks, 2 Gy in a dose per fraction) were performed in both patients. One patient (Case 1) survived without recurrence for more than 104 months after the initiation of radiation, whereas other patient died due to progression.</p><p><strong>Conclusion: </strong>To our knowledge, this is the first case report on long-term survival of a young patient with RIGBM. This case report sheds light on long-term survivors among pediatric RIGBM and the optimal radiation dose in the settings of re-irradiation.</p>","PeriodicalId":23856,"journal":{"name":"World Journal of Surgical Oncology","volume":"23 1","pages":"215"},"PeriodicalIF":2.5,"publicationDate":"2025-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12131411/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144217108","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analysis of clinical characteristics, treatment response, and prognosis among 67 patients with anaplastic multiple myeloma.","authors":"Fei Chen, Yan Wang, Zhongxia Huang, Man Qi, Hong Chen","doi":"10.1186/s12957-025-03851-w","DOIUrl":"10.1186/s12957-025-03851-w","url":null,"abstract":"<p><strong>Background: </strong>Anaplastic multiple myeloma (AMM) is a type of distinctive MM with a poor prognosis. AMM is mostly reported as individual cases, an accurate incidence and strict clinical definition are lacking.</p><p><strong>Methods: </strong>Sixty-seven patients with AMM were identified and then analyzed in the clinical database of patients with MM from January 2017 to September 2024.</p><p><strong>Results: </strong>The incidence of AMM among patients with MM was 3.3%. The IgD type accounted for 11.9% of patients, with 40.3% and 53.7% kappa and lambda light chains, respectively. Plasmablasts with larger diameters and multinuclear variations accounted for 46.7% from bone marrow or extramedullary disease (EMD) based on pathologic morphology; the average Ki-67 was 64.8%. The incidence of EMD was 49.3%. Lactic dehydrogenase (LDH) was elevated in 44.8% of patients and 49.3% of patients were International Staging System (ISS) III. The frequencies of 1q21, t (4; 14), and t (14; 16) in high-risk genes were 60.5%, 39.5%, and 18.4%, respectively. Double and triple gene hits were detected in 36.8% and 13.2% of patients, respectively. Fifty-six patients received treatment with bortezomib-based regimens. The progression-free survival (PFS) and overall survival (OS) of AMM patients in the autologous stem cell transplantation (ASCT) group were prolonged compared to patients who did not undergo ASCT with a median PFS and OS of 5.0 versus 25.0 and 17.0 versus 36.0 months, respectively (P = 0.0246 and P = 0.0119, respectively). At the time of the last follow-up, 71.4% of patients had died with 77.5% experiencing disease progression. A high neutrophil-to-lymphocyte ratio (NLR) and no ASCT were also independent prognostic factors for AMM patients.</p><p><strong>Conclusions: </strong>The incidence of AMM is rare. The characteristics of these AMM patients included extensive proliferation of plasmablasts and widespread EMD formation, AMM patients also exhibit more invasive clinical manifestations and a short survival. Patients who underwent sequential ASCT after receiving bortezomib-based regimens partially overcame the poor prognosis of AMM.</p>","PeriodicalId":23856,"journal":{"name":"World Journal of Surgical Oncology","volume":"23 1","pages":"210"},"PeriodicalIF":2.5,"publicationDate":"2025-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12126908/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144192270","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Global insight of early-onset genitourinary cancers in adolescents and adults from 1990 to 2021: temporal trends and health inequalities analyses.","authors":"Xingyang Su, Feng Chen, Zeyu Shi, Yifang Tao, Xiujuan Han, Li Xue","doi":"10.1186/s12957-025-03849-4","DOIUrl":"10.1186/s12957-025-03849-4","url":null,"abstract":"<p><strong>Background: </strong>Prostate, bladder, and kidney cancers represent the three most prevalent genitourinary malignancies, posing substantial global health burdens. Given the limited epidemiological research on early-onset genitourinary cancers (EOGCs), this study aims to investigate the temporal trends and health disparities in EOGCs from 1990 to 2021.</p><p><strong>Methods: </strong>Based on the Global Burden of Disease Study 2021 (GBD), we extracted data on the incidence, prevalence, mortality, and disability-adjusted life years (DALYs) of the three major genitourinary cancers (prostate, bladder, kidney cancer) among individuals aged 15 to 49. We described the distribution of EOGCs at the global, regional and national levels, and analyzed the overall and local time trends through the estimated annual percentage change (EAPC) and joinpoint regression. Spearman's test and health inequality analysis were used to examine the relationship between the disease burden of EOGCs and the Socio-demographic Index (SDI).</p><p><strong>Results: </strong>In 2021, the incident cases of early-onset kidney cancer (EOKC), early-onset bladder cancer (EOBC), and early-onset prostate cancer (EOPC) were 52,631, 31,054, and 17,865, respectively, with 10,978, 6,328, and 2,861 death cases. The most significant attributable risk factors for EOGC-related deaths and DALYs were smoking and high body mass index. Of particular note, male EOKC consistently demonstrated the highest age-standardized incidence rate (ASIR) and mortality rate (ASMR), with both metrics exhibiting sustained increases from 1990 to 2021, corresponding to EAPCs of 1.33% and 0.3%, respectively. The disease burdens of EOGCs were distributed differently across various regions and countries, and their local trends also varied during the period from 1990 to 2021 globally. The incidence burden of EOGCs was disproportionately concentrated in high-SDI countries, with the concentration indices of EOPC, EOBC and EOKC in 2021 being 0.26, 0.17 and 0.27 respectively. Notably, in regions or countries with a higher SDI, the incidence risk of EOGCs was relatively high, but the mortality risk decreased significantly.</p><p><strong>Conclusions: </strong>EOGCs are a major global public health challenge. There is an urgent need for personalized healthcare strategies to alleviate the burden of genitourinary cancers, particularly kidney cancer and prostate cancer, among adolescents and adults.</p>","PeriodicalId":23856,"journal":{"name":"World Journal of Surgical Oncology","volume":"23 1","pages":"208"},"PeriodicalIF":2.5,"publicationDate":"2025-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12126903/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144192272","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical features and prognostic analysis of 14 cases of appendiceal mixed neuroendocrine-non-neuroendocrine tumors with peritoneal pseudomyxoma.","authors":"Pu Zhang, Guanjun Shi, Chong Wang, Lubiao An, Yiyan Lu, Haipeng Zhou, Ruiqing Ma","doi":"10.1186/s12957-025-03857-4","DOIUrl":"10.1186/s12957-025-03857-4","url":null,"abstract":"<p><strong>Background: </strong>Appendiceal mixed neuroendocrine-non-neuroendocrine neoplasms (a-MiNENs) combined with peritoneal pseudomyxoma (PMP) represent an exceptionally rare and clinically challenging entity. This study aims to elucidate the clinical characteristics of this unique tumor subtype and identify critical prognostic factors, thereby providing insights into the management and outcomes of affected patients.</p><p><strong>Methods: </strong>We conducted a retrospective analysis of 14 patients diagnosed with a-MiNEN and PMP at the Department of Myxoma, Aerospace Center Hospital, between January 2014 and September 2022. Data included demographics, symptoms, tumor grading, treatments, and outcomes.</p><p><strong>Results: </strong>Pathological evaluation revealed a diverse spectrum of tumor grades and PMP subtypes: 5 cases were classified as G1 neuroendocrine tumors (NET), 4 as G2 NET, and 5 as G3 neuroendocrine carcinoma (NEC). Regarding PMP subtypes, 5 cases had disseminated peritoneal adenomucinosis (DPAM), 4 had peritoneal mucinous carcinomatosis (PMCA), and 5 had peritoneal mucinous carcinomatosis with signet ring cell carcinoma (PMCA-S). The median postoperative survival time was 28.55 months, with 1-year and 2-year survival rates of 80.0% and 66.7%, respectively. Patients aged < 60 years, male sex, absence of right hemicolectomy, postoperative peritoneal cancer index (PCI) ≥ 25, and perineural invasion demonstrated significantly lower 1-year and 2-year survival rates compared to their counterparts, with distinct separation observed in the Kaplan-Meier curves. These factors likely reflect biological differences in disease progression, inadequate surgical debulking, and aggressive tumor behavior.</p><p><strong>Conclusions: </strong>a-MiNEN with PMP progresses rapidly. Young patients, male patients, those with absence of right hemicolectomy, postoperative PCI ≥ 25 and perineural invasion may face poorer outcomes. This study, one of the few to analyze this rare condition, underscores the need for targeted treatments and further validation in larger cohorts.</p>","PeriodicalId":23856,"journal":{"name":"World Journal of Surgical Oncology","volume":"23 1","pages":"209"},"PeriodicalIF":2.5,"publicationDate":"2025-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12126910/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144192271","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Primary urothelial carcinoma of an ileal conduit; six decades after childhood bladder exstrophy surgery: a rare and late complication.","authors":"Areeba Ahmed, Sameen Nasir, Imran Khan Jalbani, Amna Qadri","doi":"10.1186/s12957-025-03798-y","DOIUrl":"10.1186/s12957-025-03798-y","url":null,"abstract":"<p><strong>Background: </strong>Bladder exstrophy is a rare congenital anomaly that requires surgical reconstruction or urinary diversion early in life. While adenocarcinoma is the most commonly associated malignancy, primary urothelial carcinoma arising within an ileal conduit without any evidence of disease in the entire urinary tract is exceedingly rare and has never been reported before.</p><p><strong>Case presentation: </strong>We report a case of a 64-year-old male with a history of bladder exstrophy managed with an ileal conduit in early childhood. He presented with intermittent bleeding from his urinary stoma, and subsequent evaluation revealed a high-grade invasive urothelial carcinoma arising within the ileal conduit, without involvement of the ureteric orifices or native urinary tract. Metastatic spread to the regional lymph nodes and liver underscored the aggressive disease course. Despite prompt initiation of chemotherapy and later immunotherapy, the disease progressed rapidly, leading to severe complications, including bilateral hydronephrosis requiring percutaneous nephrostomy. The patient was ultimately transitioned to palliative care.</p><p><strong>Conclusion: </strong>Primary urothelial carcinoma in an ileal conduit of bladder exstrophy patient is a rare condition. The latency period for the onset of this aggressive cancer in urinary diversions can be long but mainly occurs before the age of 65. This reinforces the need for long-term follow-up of patients with urinary diversions, even in the absence of symptoms. We advocate for routine screening of these patients, initiating before the age of 30 as previously recommended for bladder exstrophy patients.</p>","PeriodicalId":23856,"journal":{"name":"World Journal of Surgical Oncology","volume":"23 1","pages":"211"},"PeriodicalIF":2.5,"publicationDate":"2025-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12126879/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144192273","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Risk factors and predictive nomogram for non-curative resection in patients with early gastric cancer treated with endoscopic submucosal dissection: a retrospective cohort study.","authors":"Lihua Guo, Yong Ding, Jinfeng Wen, Min Miao, Kefeng Hu, Guoliang Ye","doi":"10.1186/s12957-025-03850-x","DOIUrl":"10.1186/s12957-025-03850-x","url":null,"abstract":"<p><strong>Introduction: </strong>The objective of this study was to determine independent clinicopathological factors that can predict submucosal invasion and non-curative resection (NCR) outcomes after endoscopic submucosal dissection (ESD) in patients with early gastric cancer (EGC).</p><p><strong>Methods: </strong>Data were collected from consecutive patients who underwent gastric ESD at the First Affiliated Hospital of Ningbo University between 2016 and 2023. A retrospective analysis was conducted using the chi-squared test and logistic regression analysis. Multiple logistic regression analysis was applied to investigate factors independently predicting both submucosal invasion and NCR. These factors were used to construct predictive nomograms.</p><p><strong>Results: </strong>A total of 511 patients (535 EGC lesions) underwent ESD. Of these, 452 were curative (84.7%), and 83 (15.5%) were non-curative. Multivariate analysis revealed that location in the body and fundus or cardia of the stomach, larger tumor size (≥ 30 mm), and histological undifferentiated type were independent risk factors for submucosal invasion and deep submucosal invasion in patients with EGC (all P < 0.05). Multivariate analysis showed that tumor size of 20 ~ 29 mm, tumor size ≥ 30 mm, elevated lesions, depressed lesions, undifferentiated tumors and submucosal invasion were all independent predictors of NCR for EGCs (all P < 0.05). The area under the ROC curve (AUC) of the nomogram model for predicting submucosal invasion and non-curative resection was 0.821 (95% CI, 0.758 ~ 0.884) and 0.937 (95%CI, 0.889 ~ 0.985), respectively.</p><p><strong>Conclusions: </strong>We developed nomograms to predict the risk of submucosal invasion and NCR prior to ESD. These predictive factors in addition to the existing ESD criteria can help provide the best treatment option for patients with EGC.</p>","PeriodicalId":23856,"journal":{"name":"World Journal of Surgical Oncology","volume":"23 1","pages":"213"},"PeriodicalIF":2.5,"publicationDate":"2025-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12126861/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144192320","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The prognostic role of perinephric adipose tissue macrophages in localized clear cell renal cell carcinoma.","authors":"Lu Fang, Heqin Zhan, Chao Yang, Tao Zhang, Yi Wang, Guangyuan Li","doi":"10.1186/s12957-025-03861-8","DOIUrl":"10.1186/s12957-025-03861-8","url":null,"abstract":"","PeriodicalId":23856,"journal":{"name":"World Journal of Surgical Oncology","volume":"23 1","pages":"212"},"PeriodicalIF":2.5,"publicationDate":"2025-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12126858/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144192321","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"TFE3-rearranged PEComa-like neoplasm of the kidney with carcinoma-like morphology and rapid progression: a case report.","authors":"Zhao-Jing Chen, Juan Cai, Lei Li, Jiale Ji, Xiao-Chu Yan, Xiu-Wu Bian, Mian-Fu Cao, Guang-Jie Duan","doi":"10.1186/s12957-025-03864-5","DOIUrl":"10.1186/s12957-025-03864-5","url":null,"abstract":"<p><strong>Background: </strong>TFE3-rearranged perivascular epithelioid cell tumor (PEComa)-like neoplasm is a recently recognized mesenchymal tumor with melanocytic immunophenotype and TFE3 gene rearrangement, but often lacking smooth muscle differentiation. Herein, we present a case of TFE3-rearranged PEComa-like neoplasm of the kidney to expand its clinicopathological characteristics and biological behavior.</p><p><strong>Case presentation: </strong>A 22-year-old female presented with left lumbago for more than 20 days. Abdominal computed tomography (CT) scan revealed a heterogeneous mass in the upper pole of the left kidney. Nephron-sparing surgery for renal neoplasia was performed. Histology showed carcinoma-like morphology, characterized by nests of large eosinophilic cells with prominent nucleoli and a rich capillary network. Immunohistochemistry demonstrated HMB45, melan-A, and cathepsin K positivity, focal SMA reactivity, and negativity for Pan-CK and PAX8, prompting an initial diagnosis of epithelioid angiomyolipoma/PEComa. Seventeen months post-surgery, rapid recurrence and multiple metastases occurred. A CT-guided needle biopsy revealed similar histological and immunohistochemical characteristics but with increased mitotic activity and necrosis. Subsequent TFE3 immunohistochemistry and fluorescence in situ hybridization confirmed TFE3 gene rearrangement, revising the diagnosis to TFE3-rearranged PEComa-like neoplasm.</p><p><strong>Conclusions: </strong>This case enhances our understanding of TFE3-rearranged PEComa-like neoplasm, especially its morphological spectrum and aggressive behavior, which are valuable for diagnosis and prognostic prediction.</p>","PeriodicalId":23856,"journal":{"name":"World Journal of Surgical Oncology","volume":"23 1","pages":"206"},"PeriodicalIF":2.5,"publicationDate":"2025-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12121297/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144180991","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Potential of neoadjuvant hepatic artery perfusion chemotherapy in improving surgical outcomes in hepatocellular carcinoma: a systematic review and meta-analysis.","authors":"Zi-Kui Shang, Jian-Hua Zhang, Jia-Hai Zhu, Chuan-Sen Deng, Xi-Yuan Chen, Ran-Xia, Chun-Quan Sun","doi":"10.1186/s12957-025-03859-2","DOIUrl":"10.1186/s12957-025-03859-2","url":null,"abstract":"<p><strong>Background: </strong>The purpose of this study was to assess the effectiveness of adjuvant treatment with new hepatic arterial infusion chemotherapy (HAIC) prior to hepatic resection in patients with resectable hepatocellular carcinoma (HCC).</p><p><strong>Methods: </strong>A systematic review was conducted utilizing established databases and registries as of January 15, 2025, without imposing restrictions based on language, publication date, or status. The inclusion criteria were met by studies that examined the effects of HAlC, with or without surgical intervention, in comparison to surgical treatment alone. The primary outcomes encompassed overall survival (OS) and disease-free survival (DFS), while secondary outcomes included recurrence rate and adverse events. A random effects model was employed to analyze the data.</p><p><strong>Results: </strong>A total of 10 studies involving 1,014 patients were included. The results showed that preoperative HAlC improved patient survival (OS), disease-free survival (DFS), and recurrence rates compared with surgical treatment alone. The most common grade 3 and higher adverse reactions in patients treated with preoperative HAIC included vomiting, leukopenia, neutropenia, hypothyroidism, and diarrhea.</p><p><strong>Conclusion: </strong>Preoperative HAIC has been demonstrated to enhance survival outcomes in patients with resectable HCC; however, the clinical efficacy of this approach requires further validation through large-scale design studies.</p>","PeriodicalId":23856,"journal":{"name":"World Journal of Surgical Oncology","volume":"23 1","pages":"207"},"PeriodicalIF":2.5,"publicationDate":"2025-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12123804/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144182750","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}