World Journal of Surgical Oncology最新文献

{"title":"Increasing incidence, prevalence, and mortality of lip and oral cavity cancer in adults aged 70 and older globally: findings from GBD 2021.","authors":"Shaoxing Chen, Xiaohuang Yang, Leijuan Huang, Yuanfu Xie, Yijiang Li, Yina Lin","doi":"10.1186/s12957-025-03933-9","DOIUrl":"10.1186/s12957-025-03933-9","url":null,"abstract":"","PeriodicalId":23856,"journal":{"name":"World Journal of Surgical Oncology","volume":"23 1","pages":"276"},"PeriodicalIF":2.5,"publicationDate":"2025-07-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12255997/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144620776","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The role of thymectomy during parathyroidectomy in multiple endocrine neoplasia type 1-associated hyperparathyroidism: a systematic review and meta-analysis.","authors":"Eman A Toraih, Mahmoud A AbdAlnaeem, Tanvi Bobba, Rami M Elshazli, Ahmed Abdelmaksoud, Yaser Y Bashumeel, Abdulrahman N Ghaleb, Mohammad H Hussein, Jessan A Jishu, Salem I Noureldine, Emad Kandil","doi":"10.1186/s12957-025-03773-7","DOIUrl":"10.1186/s12957-025-03773-7","url":null,"abstract":"<p><strong>Background: </strong>Current guidelines recommend transcervical thymectomy (TCT) during parathyroidectomy (PTX) for Multiple Endocrine Neoplasia Type 1 (MEN1)-associated primary hyperparathyroidism (PHPT) despite limited evidence substantiating efficacy. We aimed to determine the role of TCT in disease control and safety outcomes.</p><p><strong>Methods: </strong>A systematic review and meta-analysis were conducted on comparative observational studies exploring the efficacy of PTX with or without concomitant TCT for managing PHPT in patients with MEN1. Pooled event proportions were estimated using Freeman-Tukey double arcsine transformation method and converted to relative risk. Six studies (n = 306 patients) were included.</p><p><strong>Results: </strong>TCT showed significantly reduced rates of persistent (relative risk 0.15; 21.9% vs. 3.1%; p < 0.01) and recurrent PHPT (RR 0.34, 43.8% vs. 12.9%; p = 0.004) necessitating re-operation compared to PTX alone, suggesting improved disease control. Interestingly, the addition of TCT reduced rates of transient PHPT (RR 0.07; 9.3% vs. 0%; p < 0.01 and permanent recurrent laryngeal nerve injury (RR 0.32, 3.9% vs. 1.0%; p = 0.04), indicating possible benefits in morbidity.</p><p><strong>Conclusions: </strong>Concomitant TCT may improve the safety and efficacy of PTX in MEN1-associated PHPT by synergistically clearing all cervical disease and minimizing adverse sequelae. Our findings provide further evidence to support existing recommendations for TCT and can guide surgical decision-making.</p>","PeriodicalId":23856,"journal":{"name":"World Journal of Surgical Oncology","volume":"23 1","pages":"272"},"PeriodicalIF":2.5,"publicationDate":"2025-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12243190/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144609668","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Construction of a column-line graphical model of poor outcome of neoadjuvant regimens for muscle-invasive bladder cancer based on NLR, dNLR and SII indicators.","authors":"Bo Hu, Longsheng Wang, Shanna Qu, Tao Zhang","doi":"10.1186/s12957-025-03903-1","DOIUrl":"10.1186/s12957-025-03903-1","url":null,"abstract":"<p><strong>Background: </strong>To study the effect and predict the value of neoadjuvant treatment regimen for muscle invasive bladder cancer (MIBC) by construction of a columnar graphical model of patients by neutrophil-to-lymphocyte ratio (NLR), derived neutrophil-to-lymphocyte ratio (dNLR), and systemic immune-inflammatory index (SII) indexes.</p><p><strong>Methods: </strong>265 patients with MIBC included from May 2022 to May 2024 were retrospectively selected to receive neoadjuvant treatment regimen respectively with treatment effect assessed, among which those achieving complete response (CR), partial response (PR), or stable disease (SD) were included in responders group and those with progressive disease (PD) in non-responders group. Clinical data of both groups were compared, related factors affecting the poor outcome after neoadjuvant therapy for MIBC were analyzed by Logistic regression, ensued with analysis of predictive value of poor prognosis by construction of a columnar graph model based on the NLR, dNLR and SII indexes.</p><p><strong>Results: </strong>A total of 265 patients with MIBC were included in this paper with a disease control rate (DCR) of 84.53% (224/265) after treatment with neoadjuvant regimen, among which 224 cases with controlled disease were involved in responders group and the remaining 41 cases with PD in non-responders group. Significant differences were observed between the two groups in terms of the degree of differentiation, tumor stage, NLR, dNLR and SII index levels (P < 0.05). After the diagnosis of covariance, the VIF values of the degree of differentiation and tumor stage were 5.535 and 5.582 respectively with a tolerance of 0.181 and 0.179, indicating that there existed a covariance problem (VIF value > 5) and could be moved out of the model followed by secondary analysis. Variables with P < 0.05 in the univariate factors were involved in the multivariate Logistic regression model with results showing that NLR, dNLR, and SII were all influential factors for the poor outcome of neoadjuvant regimens after treatment of MIBC (P < 0.05). Next, the column line graph, calibration curve and ROC curve graph were constructed. It was found that the AUC of the column line graph model in predicting poor outcome after neoadjuvant regimen for MIBC registered 0.995 (95% CI: 0.99-1.00), which was valuable in predicting poor outcome after neoadjuvant regimen for MIBC. CYFRA21-1, NMP22, and BTA were significantly higher in the poor response group than in the response group (P < 0.05), and CYFRA21-1, NMP22, and BTA showed a positive correlation with NLR, dNLR, and SII in both groups, respectively (P < 0.05).</p><p><strong>Conclusion: </strong>The neoadjuvant treatment program in patients with MIBC performed better, but some patients might still have a poor outcome with higher levels of NLR, dNLR and SII compared to those with a good outcome. In addition, the value of the combination of the three indicators in the predictio","PeriodicalId":23856,"journal":{"name":"World Journal of Surgical Oncology","volume":"23 1","pages":"274"},"PeriodicalIF":2.5,"publicationDate":"2025-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12247270/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144609749","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"PD-1/PD-L1 inhibitors plus chemotherapy versus chemotherapy alone for Chinese patients with advanced non-small-cell lung cancer: an updated meta-analysis based on phase 3 randomized controlled trials.","authors":"Jianfei Zhang, Min Liu, Dongyang Li, Jiali Luo, Min Wang","doi":"10.1186/s12957-025-03934-8","DOIUrl":"10.1186/s12957-025-03934-8","url":null,"abstract":"<p><strong>Background: </strong>The combination of PD-1/PD-L1 inhibitors with chemotherapy (PC) has shown promise in treating advanced NSCLC. However, its added benefit over chemotherapy alone in Chinese patients remains unclear. We performed an updated synthesis of phase 3 randomized controlled trails (RCTs) to assess both therapeutic effectiveness and associated safety of PC therapy in this population.</p><p><strong>Methods: </strong>We systematically searched six different databases for relevant publications. Only phase 3 RCTs enrolling Chinese individuals with advanced NSCLC, contrasting PC and standalone chemotherapy, were eligible. The main outcomes were overall survival (OS) and progression-free survival (PFS). Tumor responses and adverse effects (AEs) were assessed as secondary indicators.</p><p><strong>Results: </strong>Eleven phase 3 trials including 3712 Chinese participants were analyzed. The PC group showed significant better OS (Hazard ratio [HR]: 0.65 [0.60, 0.72], P < 0.00001), and PFS (HR: 0.49 [0.46, 0.53], P < 0.00001). Better survival rate at 6 to 60 months was observed in those given PC. Presence of brain metastases and receiving pembrolizumab were associated with improved outcomes in the PC subgroup. Regarding tumor responses, PC led to longer duration of response (HR: 0.43 [0.36, 0.50], P < 0.00001), and a higher objective response rate (risk ratio [RR]: 1.60 [1.49, 1.72], P < 0.00001). However, PC group exhibited more AEs and immune-related AEs (irAEs) in all severity levels.</p><p><strong>Conclusion: </strong>PIC may offer superior clinical benefits over chemotherapy alone in Chinese patients with advanced NSCLC, though with irAEs that warrants careful monitoring.</p>","PeriodicalId":23856,"journal":{"name":"World Journal of Surgical Oncology","volume":"23 1","pages":"273"},"PeriodicalIF":2.5,"publicationDate":"2025-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12247408/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144609667","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"UBC9 overexpression promotes proliferation and metastasis in gastric cancer via ATF2.","authors":"QingShui Wang, ShengZhao Li, YiNing Xu, Yuluo Chen, Chao Xu, QiuYan He, Yan Ye, YiMin Huang, Yue Wu, KeJia Guo, YaJuan Wei, Yide Huang, Yan Liu, Qing Lin, Shanshan Wang, Feng Li, Minghan Huang, FangQin Xue, Yao Lin","doi":"10.1186/s12957-025-03922-y","DOIUrl":"10.1186/s12957-025-03922-y","url":null,"abstract":"<p><p>Gastric cancer remains a leading cause of cancer-related mortality worldwide, characterized by poor prognosis due to its aggressive nature and high metastatic potential. While the E2-conjugating enzyme UBE2I (UBC9), essential for SUMOylation, has been implicated in various cancers, its precise role in gastric cancer remains poorly understood. In the study, we demonstrate significant UBC9 overexpression in gastric cancer tissues, which correlates with poor clinical outcomes. Functional analyses revealed that UBC9 knockdown significantly suppressed gastric cancer cell proliferation, migration, and invasion in vitro and in vivo, whereas UBC9 overexpression enhanced these malignant phenotypes. Through integrated transcriptomic and proteomic analyses, we identified ATF2 (Activating Transcription Factor 2) as a crucial downstream effector of UBC9-mediated oncogenic signaling. The mechanistic relationship between these factors was confirmed as ATF2 knockdown substantially attenuated the oncogenic effects of UBC9 overexpression. This newly identified UBC9-ATF2 regulatory axis promotes gastric cancer progression by enhancing cellular proliferation and metastatic potential. Our findings establish UBC9 and ATF2 as promising prognostic biomarkers and potential therapeutic targets, suggesting that intervention in the UBC9-ATF2 axis may provide novel therapeutic strategies for inhibiting gastric cancer progression and improving patient outcomes.</p>","PeriodicalId":23856,"journal":{"name":"World Journal of Surgical Oncology","volume":"23 1","pages":"270"},"PeriodicalIF":2.5,"publicationDate":"2025-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12243259/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144601679","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Optimizing ERAS protocols in robotic nephron-sparing surgery: a randomized trial.","authors":"Yiqiang Wang, Mangmang He, Lulu Lou","doi":"10.1186/s12957-025-03927-7","DOIUrl":"10.1186/s12957-025-03927-7","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate the clinical efficacy of evidence-based Enhanced Recovery After Surgery (ERAS) nursing protocols in patients undergoing robotic-assisted partial nephrectomy using the Da Vinci system.</p><p><strong>Methods: </strong>A total of 240 patients undergoing Da Vinci robot-assisted partial nephrectomy were randomized (1:1) to ERAS (n = 120) or conventional care (n = 120) groups using a stratified block randomization method. The sample size was calculated based on a power of 80%, α = 0.05, and anticipated clinically significant differences, though specific values for the standard deviation and effect size were not disclosed. Primary outcomes included operative time, estimated blood loss, and length of hospital stay. Secondary outcomes assessed complication rates (Clavien-Dindo classification) and patient-reported comfort (Kolcaba GCQ questionnaire). Categorical variables were analyzed using the Chi-square test, while continuous variables were assessed with the independent samples t-test. Bonferroni correction was applied for pairwise comparisons to control for multiple testing. All analyses adhered to the modified intention-to-treat principle using the full analysis set (FAS), and no imputation was made for missing data. A p-value < 0.05 was considered statistically significant.</p><p><strong>Results: </strong>The ERAS group demonstrated superior recovery metrics compared to the control group: operative duration (228.6 ± 9.5 vs. 252.8 ± 10.1 min, mean difference [MD] - 24.2, 95% CI -27.3, -21.1; p < 0.001), intraoperative blood loss (200.4 ± 18.2 vs. 232.6 ± 19.3 mL, MD - 32.2, 95% CI -36.8, -27.6; p < 0.001), and shorter postoperative milestones (ambulation: 14.3 ± 1.7 vs. 18.7 ± 2.2 h, p < 0.001; catheter removal: 2.1 vs. 3.5 days, p < 0.001). Hospital stay was significantly reduced (6.2 ± 2.1 vs. 10.5 ± 3.3 days, MD - 4.3, 95% CI -5.0, -3.6; p < 0.001). Complication rates were markedly lower with ERAS (14.2% vs. 39.2%, relative risk [RR] 0.36, 95% CI 0.24-0.55; p < 0.001), particularly for urinary infections (3.3% vs. 11.7%, p = 0.027) and wound hematomas (5.0% vs. 13.3%, p = 0.025). GCQ scores improved significantly in the ERAS group post-intervention (p < 0.001).</p><p><strong>Conclusion: </strong>ERAS nursing grounded in evidence-based medicine significantly enhances postoperative recovery, reduces complications, and improves patient comfort in robotic-assisted partial nephrectomy. These findings support its broader clinical adoption.</p>","PeriodicalId":23856,"journal":{"name":"World Journal of Surgical Oncology","volume":"23 1","pages":"271"},"PeriodicalIF":2.5,"publicationDate":"2025-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12243225/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144601678","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The prognostic differences between breast-conserving surgery and mastectomy in patients with invasive ductal carcinoma who achieved complete response following neoadjuvant chemotherapy: a propensity score matched analysis based on the SEER database.","authors":"Cheng Xiao, Yuanxin Zhang, Junyan Li","doi":"10.1186/s12957-025-03932-w","DOIUrl":"10.1186/s12957-025-03932-w","url":null,"abstract":"<p><strong>Background: </strong>The study investigates the prognostic differences between breast-conserving surgery (BCS) and mastectomy in patients with invasive ductal carcinoma of the breast who achieve a complete response (CR) after neoadjuvant chemotherapy.</p><p><strong>Methods: </strong>This study analyzed data from 9,411 patients diagnosed with invasive ductal carcinoma of the breast who achieved complete response following neoadjuvant chemotherapy, using data from the SEER database between 2010 and 2019, comprising 4,219 patients in the BCS group and 5,192 in the mastectomy group. Propensity score matching (PSM) was employed to control for confounding variables, and univariate and multivariate analyses were performed to identify variables associated with overall survival (OS) and cancer-specific survival (CSS). Kaplan-Meier survival curves were used to evaluate the prognosis of patients in the two groups.</p><p><strong>Results: </strong>The multivariate Cox regression analysis demonstrated that histological subtype, T stage, N stage, surgical method, and radiotherapy were risk factors for CSS, while age, histological subtype, T stage, and N stage were associated with OS (p < 0.05). Following matching, the Kaplan-Meier survival analysis curve suggested that the BCS group had higher CSS than the mastectomy group (p < 0.05), although there was no statistically significant difference in OS between the two groups (p = 0.16). Subgroup analysis revealed that, among patients aged ≤ 50, of White ethnicity, with grade 3 tumors, and HR+/HER-2- subtype, the BCS group exhibited superior CSS compared to the mastectomy group (p < 0.05).</p><p><strong>Conclusion: </strong>Patients with invasive ductal carcinoma of the breast who achieve complete response following neoadjuvant chemotherapy experience better CSS benefits with BCS compared to undergoing mastectomy.</p>","PeriodicalId":23856,"journal":{"name":"World Journal of Surgical Oncology","volume":"23 1","pages":"269"},"PeriodicalIF":2.5,"publicationDate":"2025-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12239254/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144592399","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Primary renal mucosa-associated lymphoid tissue lymphoma coexisting with immune thrombocytopenia.","authors":"Jiatai He, Changqi Deng, Yu Huang, Miao Wang, Chengcheng Wei, Feixiang Xu, Ruokang Chen, Junduo Wang, Ming Yang, Zhaohui Chen","doi":"10.1186/s12957-025-03916-w","DOIUrl":"10.1186/s12957-025-03916-w","url":null,"abstract":"<p><strong>Background: </strong>Primary renal mucosa-associated lymphoid tissue (MALT) lymphoma is exceedingly rare. Although immune thrombocytopenia (ITP) may accompany lymphoproliferative disorders, its association with primary renal MALT lymphoma has not been previously reported.</p><p><strong>Case presentation: </strong>A 60-year-old male presenting with isolated thrombocytopenia was diagnosed with ITP during hematologic evaluation. Abdominal imaging incidentally revealed an 8.7 × 5.6 cm renal mass. Glucocorticoid therapy successfully stabilized platelet counts, enabling nephroureterectomy. Histopathological analysis demonstrated dense small lymphocyte infiltrates, with immunohistochemical confirmation of CD20 and Bcl-2 positivity establishing a diagnosis of MALT lymphoma. At six-month follow-up, the patient maintained disease-free status without adjuvant therapy.</p><p><strong>Conclusions: </strong>We report a rare case of concurrent primary renal MALT lymphoma and ITP, achieving sustained remission through glucocorticoid therapy and surgical resection.</p>","PeriodicalId":23856,"journal":{"name":"World Journal of Surgical Oncology","volume":"23 1","pages":"265"},"PeriodicalIF":2.5,"publicationDate":"2025-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12235929/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144585024","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Construction of a prediction model for peripheral lymph node metastasis in patients with colorectal cancer based on enhanced CT texture features.","authors":"Feng Tong, Longfei Zhang, Xiaobin Jiang, Zhenyu Wu","doi":"10.1186/s12957-025-03928-6","DOIUrl":"10.1186/s12957-025-03928-6","url":null,"abstract":"<p><strong>Background: </strong>To investigate the analysis of peripheral lymph node metastasis prediction model construction for patients with colorectal cancer based on enhanced CT texture features.</p><p><strong>Methods: </strong>In this study, the clinical data of 200 colorectal cancer patients admitted to our hospital from January 2019 to October 2024 were collected, which were divided into a training set (n = 140) and a validation set (n = 60) according to a 7:3 ratio. The training set was used to construct the prediction model and the validation set was used to evaluate the model performance. Independent influencing factors of peripheral lymph node metastasis in colorectal cancer patients were screened by single-factor and multifactor logistic regression analyses, and the prediction model was finally constructed and analysed for its predictive effect using ROC curves and decision curves.</p><p><strong>Results: </strong>In the training and validation sets, compared with those without lymph node metastasis, colorectal cancer patients with lymph node metastasis had a higher percentage of those whose tumour infiltration depth was submucosal and those whose tumour differentiation was poorly differentiated, and the skewness, kurtosis, and entropy values of their CT texture features were also significantly higher than those without lymph node metastasis (P < 0.05). Multifactorial logistic regression analysis showed that the depth of tumour infiltration was higher for submucosal layer (OR = 3.367, 95% CI = 1.104 ~ 1.271), tumour hypofractionation (OR = 3.881, 95% CI = 1.04714.392), skewness (OR = 3.979, 95% CI = 1.04714.392), kurtosis (OR = 4.824, 95% CI = 2.251 ~ 10.336), and entropy (OR = 2.221, 95% CI = 1.159 ~ 4.257) were independent risk factors for lymph node metastasis in colorectal cancer patients. The consistency index (C-index) of the lymph node metastasis prediction model based on enhanced CT texture features was 0.980, and the calibration curve results were basically consistent with the predicted values; the AUCs of lymph node metastasis prediction for the training and validation sets were 0.937 and 0.960, respectively. Decision curve analysis showed that the clinical decision-making benefit of the model was significantly improved after adding CT texture features.</p><p><strong>Conclusion: </strong>The prediction model based on enhanced CT texture features has good predictive value for predicting peripheral lymph node metastasis in colorectal cancer.</p>","PeriodicalId":23856,"journal":{"name":"World Journal of Surgical Oncology","volume":"23 1","pages":"266"},"PeriodicalIF":2.5,"publicationDate":"2025-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12236036/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144585021","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analysis of frailty change trajectories and its risk factors in patients with gastrointestinal tumor surgery: a prospective observational longitudinal study.","authors":"Junli You, Xiaohong Lv, Yu Rong, Xuepiao Chen, Tianxiao Liu, Yubo Xie","doi":"10.1186/s12957-025-03924-w","DOIUrl":"10.1186/s12957-025-03924-w","url":null,"abstract":"<p><strong>Background: </strong>Frailty is a dynamic process, but its changes following surgery are unclear. This study aimed to investigate frailty change trajectories and their risk factors in older patients undergoing gastrointestinal tumor surgery.</p><p><strong>Methods: </strong>The Frail Scale (FS) assessed frailty from preoperative to 180 days after surgery. The latent class analysis (LCA) was established to identify the most fitting latent class, and the risk factors of these change trajectories were analyzed. We also recorded and explored changes in FS components.</p><p><strong>Results: </strong>212 elderly patients (aged ≥ 60 years) scheduled for gastrointestinal tumor surgery under general anesthesia completed the study. The LCA identified four optimal trajectory groups. There are differences in gender, age, marriage, American Society of Anesthesiologists (ASA) classification, number of comorbidities, hemoglobin, Charlson comorbidity index (CCI), the six-minute walk test (6MWT), metabolic equivalent (MET), preoperative frailty status, and time to first ambulation among the four groups (P < 0.05). Comorbidities, MET, preoperative frailty, age, first time to ambulation, and 6WMT were independent factors influencing abnormal frailty trajectories. Overall, the FS components all changed 180 days after the surgery. Except for weight loss, the changes in the other components were related to the surgical site (P < 0.05).</p><p><strong>Conclusion: </strong>Frailty is a dynamic process. Older patients with more comorbidities, low MET and 6WMT, preoperative frailty, and later time to ambulation are prone to remain in frailty or transition to it after surgery. Clinical attention and targeted rehabilitation should be provided to them.</p>","PeriodicalId":23856,"journal":{"name":"World Journal of Surgical Oncology","volume":"23 1","pages":"264"},"PeriodicalIF":2.5,"publicationDate":"2025-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12235829/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144585020","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}