Primary renal mucosa-associated lymphoid tissue lymphoma coexisting with immune thrombocytopenia.

IF 2.5 3区医学 Q3 ONCOLOGY

World Journal of Surgical Oncology Pub Date : 2025-07-07 DOI:10.1186/s12957-025-03916-w

Jiatai He, Changqi Deng, Yu Huang, Miao Wang, Chengcheng Wei, Feixiang Xu, Ruokang Chen, Junduo Wang, Ming Yang, Zhaohui Chen

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引用次数: 0

Abstract

Background: Primary renal mucosa-associated lymphoid tissue (MALT) lymphoma is exceedingly rare. Although immune thrombocytopenia (ITP) may accompany lymphoproliferative disorders, its association with primary renal MALT lymphoma has not been previously reported.

Case presentation: A 60-year-old male presenting with isolated thrombocytopenia was diagnosed with ITP during hematologic evaluation. Abdominal imaging incidentally revealed an 8.7 × 5.6 cm renal mass. Glucocorticoid therapy successfully stabilized platelet counts, enabling nephroureterectomy. Histopathological analysis demonstrated dense small lymphocyte infiltrates, with immunohistochemical confirmation of CD20 and Bcl-2 positivity establishing a diagnosis of MALT lymphoma. At six-month follow-up, the patient maintained disease-free status without adjuvant therapy.

Conclusions: We report a rare case of concurrent primary renal MALT lymphoma and ITP, achieving sustained remission through glucocorticoid therapy and surgical resection.

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原发性肾粘膜相关淋巴组织淋巴瘤伴免疫性血小板减少症。

背景：原发性肾黏膜相关淋巴组织淋巴瘤（MALT）极为罕见。尽管免疫性血小板减少症（ITP）可能伴随淋巴细胞增生性疾病，但其与原发性肾MALT淋巴瘤的关系尚未报道。病例介绍：一名60岁男性，在血液学评估中被诊断为ITP，表现为孤立性血小板减少症。腹部影像显示一个8.7 × 5.6 cm的肾脏肿块。糖皮质激素治疗成功稳定血小板计数，使肾输尿管切除术成为可能。组织病理学分析显示密集的小淋巴细胞浸润，免疫组织化学证实CD20和Bcl-2阳性，诊断为MALT淋巴瘤。在6个月的随访中，患者在没有辅助治疗的情况下保持无病状态。结论：我们报告一例罕见的原发性肾MALT淋巴瘤并发ITP，通过糖皮质激素治疗和手术切除获得持续缓解。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

World Journal of Surgical Oncology ONCOLOGY-SURGERY

CiteScore

4.70

自引率

15.60%

发文量

362

审稿时长

3 months

期刊介绍： World Journal of Surgical Oncology publishes articles related to surgical oncology and its allied subjects, such as epidemiology, cancer research, biomarkers, prevention, pathology, radiology, cancer treatment, clinical trials, multimodality treatment and molecular biology. Emphasis is placed on original research articles. The journal also publishes significant clinical case reports, as well as balanced and timely reviews on selected topics. Oncology is a multidisciplinary super-speciality of which surgical oncology forms an integral component, especially with solid tumors. Surgical oncologists around the world are involved in research extending from detecting the mechanisms underlying the causation of cancer, to its treatment and prevention. The role of a surgical oncologist extends across the whole continuum of care. With continued developments in diagnosis and treatment, the role of a surgical oncologist is ever-changing. Hence, World Journal of Surgical Oncology aims to keep readers abreast with latest developments that will ultimately influence the work of surgical oncologists.