World Journal of Surgical Oncology最新文献

{"title":"eIF6: a promising therapeutic target for gastric carcinoma via PI3K/AKT pathway modulation.","authors":"Shuang Hou, Hao Tang, Zhikun Dong, Wence Zhou","doi":"10.1186/s12957-025-03746-w","DOIUrl":"https://doi.org/10.1186/s12957-025-03746-w","url":null,"abstract":"<p><strong>Background: </strong>Gastric carcinoma (GC) is a leading cause of cancer-related deaths, with a dire prognosis for advanced stages. The molecular mechanisms underlying GC progression are not fully understood, necessitating research into novel biomarkers and therapeutic targets. This study investigates the role of eukaryotic translation initiation factor 6 (eIF6) in GC, focusing on its potential as a prognostic indicator and its impact on tumor biology.</p><p><strong>Methods: </strong>We analyzed eIF6 expression in GC tissues using data from TCGA and GEO databases. Experiments included western blot, IHC staining, and cell culture assays on GC cell lines to evaluate the effect of eIF6 on cell proliferation, invasion, and apoptosis. Statistical analyses were performed using Student's t-tests and ANOVA, with significance set at p < 0.05.</p><p><strong>Results: </strong>eIF6 was found to be significantly overexpressed in GC tissues, associated with advanced tumor stage and poor patient survival. Functional assays demonstrated that eIF6 knockdown inhibits GC cell proliferation and invasion while promoting apoptosis. Transcriptomic analysis linked eIF6 to the PI3K/AKT pathway, a critical regulator in cancer.</p><p><strong>Conclusions: </strong>eIF6's overexpression in GC suggests its role in tumor progression, highlighting its potential as a therapeutic target. The study provides a foundation for developing targeted therapies against eIF6 and emphasizes the need for further research into its regulatory mechanisms in GC.</p>","PeriodicalId":23856,"journal":{"name":"World Journal of Surgical Oncology","volume":"23 1","pages":"113"},"PeriodicalIF":2.5,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143765258","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pancreatic atrophy after gastric cancer surgery: influencing factors and effects on BMI and quality of life.","authors":"Zhaoping Li, Lianlian Cao, Hao Chen, Feng Wang, Liang Tao, Meng Wang","doi":"10.1186/s12957-025-03761-x","DOIUrl":"https://doi.org/10.1186/s12957-025-03761-x","url":null,"abstract":"<p><strong>Background: </strong>Pancreatic atrophy can occur after gastric cancer surgery, but the influencing factors and effects of pancreatic atrophy have not been extensively studied. The aim of this study was to investigate the factors of pancreatic atrophy after gastric cancer surgery and to assess the effect of atrophy on BMI and quality of life, in order to promote postoperative management of patients with higher risk factors of pancreatic atrophy.</p><p><strong>Methods: </strong>Clinical data pertaining to 142 patients who underwent surgery for gastric cancer were retrospectively collected, and pancreatic volume was determined using abdominal computed tomography data. Influencing factors of pancreatic atrophy were analysed and the relationship of pancreatic atrophy to BMI and quality of life was measured. Correlation analysis using Pearson or Spearman rank correlation and multiple linear regression were used to analyse the risk factors influencing pancreatic atrophy.</p><p><strong>Results: </strong>Pancreatic atrophy was significant in patients with gastric cancer 1 year after surgery, regardless of the surgical procedure. T3 and T4 stages, preoperative low levels of high-density lipoprotein cholesterol(HDL-C) and smoking history were influencing factors of pancreatic atrophy. Pancreatic atrophy was associated with reduced BMI and deterioration of quality of life.</p><p><strong>Conclusions: </strong>Clinicians need to monitor pancreatic function, BMI and life quality more carefully in gastric cancer patients with T3 and T4 stages, preoperative low levels of HDL-C and smoking history.</p>","PeriodicalId":23856,"journal":{"name":"World Journal of Surgical Oncology","volume":"23 1","pages":"112"},"PeriodicalIF":2.5,"publicationDate":"2025-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143754795","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Targeting NETO2 suppresses cell proliferation, invasion, and migration and inactivates the STAT3/C-MYC pathway in hepatocellular carcinoma.","authors":"Na Shun Meng He, Xinghua Wu, Shu Chen, Xinyi Yun, Shun Yao, Hai Yu","doi":"10.1186/s12957-025-03717-1","DOIUrl":"https://doi.org/10.1186/s12957-025-03717-1","url":null,"abstract":"<p><strong>Background: </strong>Neuropilin and tolloid-like 2 (NETO2) facilitates the progression of various cancers, but its role in hepatocellular carcinoma (HCC) is not known. This study aimed to assess the potential of targeting NETO2 in HCC and its relationship with the STAT3/C-MYC pathway.</p><p><strong>Methods: </strong>HCC cells (Huh7 and MHCC-97 H) were cultured and transfected with control siRNA (siCtrl), NETO2 siRNA (siNETO2), control overexpression (oeCtrl), or NETO2 overexpression (oeNETO2), with non-transfected cells used as blank controls.</p><p><strong>Results: </strong>NETO2 mRNA and protein expressions were reduced in both Huh7 and MHCC-97 H cells. EdU and CCK-8 assays indicated that cell proliferation was decreased after siNETO2 transfection in Huh7 and MHCC-97 H cells. TUNEL assay found revealed that the cell apoptosis rate was greater after siNETO2 transfection in MHCC-97 H cells, and tended to be greater in Huh7 cells (but the difference was not statistically significant). Transwell invasion assay revealed that the number of invasive Huh7 and MHCC-97 H cells decreased after siNETO2 transfection. Cell scratch assay revealed that the cell migration rate was reduced after siNETO2 transfection in Huh7 cells but was not significantly different in MHCC-97 H cells. Western blotting revealed that p-STAT3 and C-MYC expressions were decreased after siNETO2 transfection in Huh7 and MHCC-97 H cells. Overexpression experiments revealed that cell proliferation and invasion were promoted but that the cell apoptosis rate was reduced after oeNETO2 transfection in Huh7 and MHCC-97 H cells.</p><p><strong>Conclusion: </strong>NETO2 knockdown suppresses HCC cell proliferation, invasion, and migration and inactivates the STAT3/C-MYC pathway, suggesting that NETO2 is a potential target for HCC treatment.</p>","PeriodicalId":23856,"journal":{"name":"World Journal of Surgical Oncology","volume":"23 1","pages":"107"},"PeriodicalIF":2.5,"publicationDate":"2025-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143744061","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical outcomes of double-flap technique versus gastric tube reconstruction following laparoscopic proximal gastrectomy: a multicenter propensity score-matched cohort study.","authors":"Zhu Jingtao, Chen Shaoqin, Zhang Tao, Yang Li, You Sheng, Hong Qingqi, Lin Hexin, Chen Yinan, Yu Huangdao, Chen Yifu, Yu Xuejun, You Jun","doi":"10.1186/s12957-025-03672-x","DOIUrl":"https://doi.org/10.1186/s12957-025-03672-x","url":null,"abstract":"<p><strong>Background: </strong>Various anti-reflux procedures are currently utilized for digestive tract reconstruction following proximal gastrectomy (PG), but the optimal reconstruction method remains debated. This study aims to compare and analyze the clinical outcomes and postoperative quality of life between double-flap technique (DFT) and gastric tube (GT) reconstruction after laparoscopic proximal gastrectomy (LPG), providing a reference for selecting the appropriate digestive tract reconstruction method.</p><p><strong>Methods: </strong>This multicenter, retrospective cohort study employed propensity score matching (PSM) to address baseline imbalances. Clinical, pathological, and follow-up data were collected from 124 patients who underwent either LPG-GT or LPG-DFT between January 2016 and May 2023 at four medical centers in China. The surgical outcomes, incidence of postoperative gastroesophageal reflux and anastomotic stricture, postoperative nutritional status, and quality of life were compared between the two groups.</p><p><strong>Results: </strong>After 1:1 PSM, 41 patients were included in each group for analysis. Compared to the LPG-GT group, the LPG-DFT group had a longer operation time (340.0 min vs. 280.0 min, P < 0.001) but less intraoperative blood loss (80.0 ml vs. 100.0 ml, P < 0.001), a shorter time to nasogastric tube removal (3.0 days vs. 5.0 days, P < 0.001), and shorter postoperative hospital stay (9.0 days vs. 12.0 days, P < 0.001). The incidence of gastroesophageal reflux in the LPG-DFT and LPG-GT groups was 7.3% and 24.3% (P = 0.034), respectively, and the incidence of anastomotic stricture requiring dilation was 14.6% and 7.3% (P = 0.480). One year postoperatively, BMI (22.0 kg/m² vs. 20.6 kg/m², P = 0.010) and albumin levels at six months postoperatively (41.6 g/L vs. 39.1 g/L, P = 0.033) were significantly higher in the LPG-DFT group. However, albumin levels one year postoperatively showed no significant difference between the two groups (42.3 g/L vs. 40.7 g/L, P = 0.226).</p><p><strong>Conclusion: </strong>The surgical outcomes suggest that both LPG-GT and LPG-DFT are safe and feasible methods. However, LPG-DFT provides better anti-reflux effects and may help reduce the risk of postoperative malnutrition.</p>","PeriodicalId":23856,"journal":{"name":"World Journal of Surgical Oncology","volume":"23 1","pages":"110"},"PeriodicalIF":2.5,"publicationDate":"2025-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143744070","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"AEBP1 inhibition reduces cell growth and PI3K/AKT pathway while less regulates cell mobility in hepatocellular carcinoma.","authors":"Liyou Liu, Qingshan Cai, Dongyang Wu, Shudong Li, Dong Liu, Jianxing Zheng","doi":"10.1186/s12957-025-03750-0","DOIUrl":"https://doi.org/10.1186/s12957-025-03750-0","url":null,"abstract":"<p><strong>Background: </strong>Adipocyte enhancer-binding protein 1 (AEBP1) regulates collagen fibrosis, extracellular matrix, and important oncogene pathways, but its regulation on hepatocellular carcinoma (HCC) is not known. This study aimed to investigate the effect of AEBP1 knockdown on HCC cell proliferation, apoptosis, migration, invasion and PI3K/AKT pathway.</p><p><strong>Methods: </strong>MHCC-97 H and Huh7 cell lines were applied. Negative control or AEBP1 siRNA (siAEBP1) were transfected into cells, and cells without transfection were set as blank control. Quantitative polymerase chain reaction (qPCR), western blot, Cell Counting Kit-8 (CCK-8), 5-Ethynyl-2'-deoxyuridine (EdU) staining, Terminal-deoxynucleotidyl Transferase Mediated Nick End Labeling (TUNEL) staining, Transwell invasion, and cell scratch assays were performed.</p><p><strong>Results: </strong>AEBP1 mRNA and protein expressions were lower after siAEBP1 transfection in MHCC-97 H and Huh7 cells. OD value of CCK-8 and EdU positive cell percentage were decreased, while TUNEL reflected cell apoptosis rate was increased, after siAEBP1 transfection in MHCC-97 H and Huh7 cells. However, invasive cell number and cell migration rate were only reduced after siAEBP1 transfection in Huh7 cells but not in MHCC-97 H cells. Expressions of p-PI3K/PI3K and p-AKT/AKT were downregulated after siAEBP1 transfection in MHCC-97 H and Huh7 cells. Subsequent rescue experiment revealed that th activation of PI3K/AKT pathway by 740Y-P attenuated the effect of siAEBP1 transfection in MHCC-97 H and Huh7 cells.</p><p><strong>Conclusion: </strong>AEBP1 exhibits the potency to be a target for HCC treatment, reflected by its regulation on HCC proliferation, apoptosis and PI3K/AKT pathway, but its effect on HCC invasion and migration seems limited.</p>","PeriodicalId":23856,"journal":{"name":"World Journal of Surgical Oncology","volume":"23 1","pages":"108"},"PeriodicalIF":2.5,"publicationDate":"2025-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143744068","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The diagnostic value of a breast cancer diagnosis model based on serum MiRNAs and serum tumor markers.","authors":"Xiaohui Li, Feng Wang, Faquan Lin, Binbin Xie, Yi Liu, Yi Xiao, Kai Qin, Weicheng Li, Qiyan Zeng","doi":"10.1186/s12957-025-03719-z","DOIUrl":"https://doi.org/10.1186/s12957-025-03719-z","url":null,"abstract":"<p><strong>Background: </strong>Breast cancer (BCa) is the leading cause of cancer-related death among women worldwide. MicroRNAs (miRNAs) are promising tools for diagnosis and prognosis. This study investigated the role of serum miRNAs and tumor markers (TMs) in the diagnosis of BCa.</p><p><strong>Methods: </strong>Differentially expressed miRNAs were screened from serum samples of BCa patients and healthy individuals via high-throughput sequencing. The expression of hsa-miR-1911-3p, hsa-miR-4694-5p, hsa-miR-548ao-5p, and hsa-miR-4804-3p in 169 BCa patients and 116 healthy controls was detected via qRT-PCR. Serum tumor-associated antigens were detected by chemiluminescence. Logistic regression was subsequently used to develop the miRNA panel I, TM panel II, and (miRNA + TM) panel III models. Receiver operating characteristic (ROC) curve, precision-recall (PR) curve and decision curve analyses (DCA) were performed to assess the accuracy of the three models for BCa diagnosis. Additionally, the relationships between miRNA expression and the clinical characteristics of patients with BCa were assessed.</p><p><strong>Results: </strong>Four serum miRNAs (hsa-miR-1911-3p, hsa-miR-548ao-5p, hsa-miR-4694-5p, and hsa-miR-4804-3p) were newly associated with BCa. The miRNA panel I based on hsa-miR-548ao-5p and hsa-miR-4804-3p showed greater diagnostic effectiveness for BCa than TM panel II based on cancer antigen 125 (CA125) and cancer antigen 153 (CA153), with AUC values of 0.816 and 0.777, respectively. (miRNA + TM) panel III had higher diagnostic effectiveness than miRNA panel I, with an AUC value of 0.870. The expression of miR-548ao-5p and miR-4804-3p is closely related to clinical features, such as human epidermal growth factor receptor 2 (HER2), estrogen receptor (ER), progesterone receptor (PR), HER2-enriched subtype, stage III/IV, and lymph node-transplanted breast cancer.</p><p><strong>Conclusion: </strong>MiR-548ao-5p and miR-4804-3 could serve as potential biomarkers for the diagnosis of BCa.</p>","PeriodicalId":23856,"journal":{"name":"World Journal of Surgical Oncology","volume":"23 1","pages":"109"},"PeriodicalIF":2.5,"publicationDate":"2025-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143744076","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"SMARCA4-deficient non-small cell lung cancer with metastasis to the sigmoid colon: a case report.","authors":"Rong Xiao, Guang Fu, Xinglan Li, Tao Lu","doi":"10.1186/s12957-025-03757-7","DOIUrl":"https://doi.org/10.1186/s12957-025-03757-7","url":null,"abstract":"<p><strong>Background: </strong>SWI/SNF-related, matrix-associated, actin-dependent regulator of chromatin, subfamily a, member 4-deficient non-small cell lung cancer (SMARCA4-dNSCLC) is a rare subtype of NSCLC whose definitive radiographic characteristics have not yet been fully delineated. Clinically, these tumors often metastasize to distant organs and lymph nodes at an early stage, which is strongly associated with poor clinical prognosis. The common metastatic sites include bone, brain, adrenal glands, liver, and spleen, whereas intestinal metastasis is extremely rare. In this case, we describe a rare instance of SMARCA4-deficient NSCLC with metastasis to the sigmoid colon.</p><p><strong>Case description: </strong>A 59-year-old male presented with hoarseness and shortness of breath. Computed tomography (CT) imaging revealed an irregular mass in the posterior apical segment of the upper lobe of the left lung, with enlarged lymph nodes in the mediastinum and left lung hilum. A biopsy of the lung mass confirmed the diagnosis of NSCLC with SMARCA4 gene deletion. CT also revealed uneven thickening of the sigmoid colon wall, which was proved to be metastases from the lung cancer through surgical pathology. The patient initially underwent chemotherapy combined with immunotherapy and intensity-modulated radiotherapy for the lungs. However, a follow-up CT revealed progression in the sigmoid colon tumor. Consequently, the patient underwent laparoscopic radical sigmoid colectomy with regional lymph node dissection. Two months postoperatively, metastasis to the left adrenal gland was detected. The treatment regimen was adjusted to a combination therapy consisting of gemcitabine, nedaplatin, bevacizumab, and camrelizumab accordingly. The patient demonstrated a favorable response to this treatment, with no evidence of recurrence or further metastasis to date.</p><p><strong>Conclusions: </strong>This case represents the first reported instance of SMARCA4-dNSCLC with metastasis to the sigmoid colon. The atypical clinical and radiological features of this condition pose significant diagnostic challenges, particularly in differentiating metastatic lesions from primary colonic tumors. This case underscores the significance of recognizing rare metastatic patterns in SMARCA4-dNSCLC, enriching the literature on its diverse manifestations and providing a critical reference for clinicians in diagnosing and managing SMARCA4-dNSCLC with sigmoid colon metastasis.</p>","PeriodicalId":23856,"journal":{"name":"World Journal of Surgical Oncology","volume":"23 1","pages":"106"},"PeriodicalIF":2.5,"publicationDate":"2025-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143744059","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Completion of nodal dissection in cutaneous melanoma with metastatic sentinel nodes: Prognostic impact in a population-based cohort study.","authors":"Alessandra Buja, Massimo Rugge, Chiara Trevisiol, Anna Zanovello, Marcodomenico Mazza, Luigi Dall'Olmo, Manuel Zorzi, Antonella Vecchiato, Paolo Del Fiore, Carlo Riccardo Rossi, Simone Mocellin","doi":"10.1186/s12957-025-03762-w","DOIUrl":"https://doi.org/10.1186/s12957-025-03762-w","url":null,"abstract":"<p><strong>Background: </strong>In primary cutaneous melanoma (CM) with metastatic sentinel lymph node(s) (SLNB), treatment strategies may include completing a regional lymph node dissection (CLND). The prognostic benefit of this therapeutic approach remains a topic of debate. This retrospective, population-based cohort study explores the prognostic impact of CLND in a real-world clinical setting.</p><p><strong>Methods: </strong>This study analysed 280 incident cases of AJCC stage III CM with metastatic SLNB, as recorded by the Veneto population-based Regional Cancer Registry in 2015, 2017, and 2019. The overall survival and CM-specific survival rates were compared between patients who underwent CLND and those who did not. Kaplan-Meier analysis, Cox regression, and Fine-Gray models for competing risks tested the relationship between lymphadenectomy and overall and CM-specific survival.</p><p><strong>Results: </strong>Among CM patients with metastatic SLNB, 199/280 (71.1%) proceeded with CLND. When compared to those who did not receive treatment, CLND did not demonstrate significant advantages in terms of overall survival and CM-specific survival rates. The cost analysis found no significant differences in treatment choice (estimated costs: €23,695.71 for the treated group and €25,003.55 for the untreated group [p = 0.69]).</p><p><strong>Conclusions: </strong>The present real-world data support omitting CLND in stage III CM with histologically documented sentinel nodal metastasis.</p>","PeriodicalId":23856,"journal":{"name":"World Journal of Surgical Oncology","volume":"23 1","pages":"111"},"PeriodicalIF":2.5,"publicationDate":"2025-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143744074","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dexmedetomidine alleviates the pro-tumor activity of perioperative stress in tumor-bearing mice: an alternative approach of psycho-physiological intervention.","authors":"Shanqing Xu, Yongzhong Tang, Jianbin Tong","doi":"10.1186/s12957-025-03665-w","DOIUrl":"https://doi.org/10.1186/s12957-025-03665-w","url":null,"abstract":"<p><strong>Background: </strong>The immediate perioperative period (IPP) usually is highly stressful and has significant effects on the postoperative recurrence/metastasis of tumors. Effective methods for limiting the impact of the IPP on postoperative recurrence/metastasis of tumors remain scarce. We aimed to determine the effects of dexmedetomidine (DEX) treatment during the IPP on postoperative recurrence/metastasis of tumors and the stress response.</p><p><strong>Materials and methods: </strong>The clinical perioperative setting was mimicked via tumor resection and perioperative restraint stress in tumor-bearing mice with or without DEX during the IPP. The stress response was assessed using stress hormone and interleukin (IL)-6 levels in peripheral blood. Tumor cell growth was measured via in vivo bioluminescent imaging, cell viability assay, wound-healing assay, and Western blotting.</p><p><strong>Results: </strong>In tumor-bearing mice, DEX during the IPP limited the growth of implanted tumor cells and stress response in a dose-dependent manner. The serum from mice without DEX promoted cultured tumor cell growth, which was alleviated by beta-adrenergic receptor blocker propranolol or IL-6 antibody. Relative to the serum from mice without DEX, the serum from mice with DEX had lower stress hormone and IL-6 levels, as well as weaker effects on tumor growth promotion. Dexmedetomidine supplementation during culture had no significant effects on tumor cells.</p><p><strong>Conclusions: </strong>Dexmedetomidine alleviates the pro-tumor activity of perioperative stress in abdominal tumors.</p>","PeriodicalId":23856,"journal":{"name":"World Journal of Surgical Oncology","volume":"23 1","pages":"103"},"PeriodicalIF":2.5,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11951540/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143744055","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Colorectal cancer at the anastomotic site following childhood surgery for hirschsprung disease: a rare case report.","authors":"Matthias Mehdorn, Philipp Rhode, Jan-Hendrik Gosemann, Katja Grunwald, Hans-Jonas Meyer, Martin Lacher, Sigmar Stelzner","doi":"10.1186/s12957-025-03754-w","DOIUrl":"https://doi.org/10.1186/s12957-025-03754-w","url":null,"abstract":"<p><strong>Background: </strong>The present case of a colorectal adenocarcinoma at the anastomotic site of a colorectal anastomosis after childhood surgery for Hirschsprung disease is a rare report of such pathology. Possibly, the altered anatomy after Duhamel procedure may pose a risk for carcinogenesis in those patients. The previously surgically opened plane of the mesorectal fascia, which is usually dissected during total mesorectal excision in rectal cancer, and the impossibility to differentiate from colon or rectal cancer in this case influence oncologic treatment strategies. Furthermore, the case highlights functional aspects of lower anterior resection syndrome before and after rectal cancer surgery with a coloanal anastomosis and how this influences quality of life.</p><p><strong>Case presentation: </strong>We report a rare case of a 54-year-old male with a history of Hirschsprung disease, treated with a Duhamel procedure during childhood, who developed colorectal cancer at the site of the colorectal anastomosis. The Duhamel procedure, a common surgical technique in Hirschsprung disease, involves creating a deep colorectal anastomosis with a retained rectal stump. The tumor, a moderately differentiated adenocarcinoma, was treated with total mesorectal excision and intersphincteric resection with a hand-sewn coloanal anastomosis and a loop ileostomy. Postoperative complications included paralytic ileus and urinary retention, but the ileostomy was successfully reversed. Despite increased LARS (lower anterior resection syndrome) scores postoperatively, the patient adapted well, reporting minimal impact on quality of life. In the short term of 1.5 years post-surgery, the patient is disease-free.</p><p><strong>Conclusion: </strong>This case highlights the need for awareness of potential colorectal cancer development in patients with a history of Hirschsprung disease and emphasizes the importance of individualized management and close surveillance strategies.</p>","PeriodicalId":23856,"journal":{"name":"World Journal of Surgical Oncology","volume":"23 1","pages":"105"},"PeriodicalIF":2.5,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11951576/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143744072","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}