World Journal of Surgical Oncology最新文献

{"title":"A novel and effective strategy for the treatment of large hepatic hemangioma: combining preoperative embolization with laparoscopic-assisted and ultrasound-guided ablation.","authors":"Xin Jin, Ziman Zhu, Wei Zhao, Liyuan Sun, Bin Hu, Hongbo Huan, Yuliang Tu, Dadong Wang, Kai Jiang","doi":"10.1186/s12957-025-03856-5","DOIUrl":"10.1186/s12957-025-03856-5","url":null,"abstract":"<p><strong>Background: </strong>Hepatic hemangioma is the most common benign liver tumor. This study aims to evaluate the feasibility, safety and efficacy of Trans-arterial embolization (TAE) combined with thermal ablation in the treatment of large hepatic hemangioma (> 5 cm).</p><p><strong>Methods: </strong>From January 2018 to December 2021, 82 patients and 112 large HH with a maximum mean diameter of 8.24 ± 0.26 cm (range: 4.3-16.0 cm) and a cumulative diameter of 9.45 ± 0.45 cm (range:5.0-29.6 cm) were treated with laparoscopic-assisted and ultrasound (US)-guided percutaneous radiofrequency ablation (RFA) or microwave ablation (MWA) during a single general anesthesia episode following TAE. After surgery, therapeutic efficacy was assessed by contrast-enhanced imagings during follow-up. Median follow-up time was 14 months (range: 2-48 months).</p><p><strong>Results: </strong>All patients have a mean operating time of 79.10 ± 2.59 min. The plain CT revealed that 112 treated lesions were totally covered (100%). Hemoglobinuria was detected in 28 patients (34.1%), and there were no cases of acute renal failure. Abdominal pain occurred in 40 patients (48.8%), while peritoneal effusion in six (7.3%). Acute cholecystitis developed in 11 patients (13.4%), constipation in five (6.1%), and nausea and vomiting in 14 (17.1%). According to the Clavien-Dindo classification, 54 patients (65.9%) had minor complications, while none had severe complications. The follow-up, no Hepatic hemangioma growth was observed.</p><p><strong>Conclusion: </strong>Preoperative TAE combined with thermal ablation is a novel therapeutic strategy for large HH. This strategy is simple, less risky, and feasible.</p>","PeriodicalId":23856,"journal":{"name":"World Journal of Surgical Oncology","volume":"23 1","pages":"203"},"PeriodicalIF":2.5,"publicationDate":"2025-05-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12102798/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144143777","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Rare Case of Adrenal Intravascular Large B-Cell Lymphoma Diagnosed via Percutaneous Needle Biopsy.","authors":"Jiafei Zeng, Jin Li, Shuai Luo, Jinjing Wang","doi":"10.1186/s12957-025-03855-6","DOIUrl":"10.1186/s12957-025-03855-6","url":null,"abstract":"<p><strong>Background: </strong>Intravascular large B-cell lymphoma (IVLBCL) is a rare subtype of diffuse large B-cell lymphoma, predominantly affecting the elderly. The disease often involves multiple tissues and organs, leading to a wide range of nonspecific symptoms. Early detection is challenging due to the absence of prominent signs such as enlarged lymph nodes or significant blood and bone marrow abnormalities in the early stages. Moreover, biopsy specimens may be insufficient for accurate diagnosis, resulting in a high false-negative rate and delayed treatment initiation.</p><p><strong>Case presentation: </strong>A 61-year-old male presented with a bilateral adrenal mass detected during routine examination. The patient had a history of diabetes, managed with regular antidiabetic medications and good blood sugar control for over a year. Symptoms included dizziness and mild bilateral flank discomfort. Imaging revealed patchy, soft tissue lesions in both adrenal glands on an upper abdominal CT scan. The larger lesion measured 71 × 37 mm on the left, and 51 × 31 mm on the right. Enhanced imaging showed mild to moderate enhancement, with neoplastic lesions or metastasis suspected. A CT-guided percutaneous biopsy was performed. Histopathological examination revealed large or medium-sized lymphoma-like cells localized to endothelial markers CD31 and CD34-positive lumen epithelium, with strong diffuse positivity for B-lymphocyte markers. The final diagnosis was IVLBCL. The patient was treated with rituximab combined with CHOP chemotherapy and discharged without significant symptoms.</p><p><strong>Conclusions: </strong>IVLBCL is often overlooked due to its varied and nonspecific clinical presentation, making early diagnosis difficult. The disease progresses rapidly and has a poor prognosis, with definitive diagnosis relying on pathological findings. Increased awareness of this rare lymphoma is crucial, particularly for diagnosing needle biopsy specimens in patients with mild symptoms and no distinct space-occupying lesions. Careful morphological examination, supported by targeted immunohistochemical staining (for B-cell and endothelial markers), is essential for timely diagnosis.</p>","PeriodicalId":23856,"journal":{"name":"World Journal of Surgical Oncology","volume":"23 1","pages":"200"},"PeriodicalIF":2.5,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12100946/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144132890","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Transoral endoscopy-assisted low-temperature plasma for the treatment of oropharyngeal malignant tumours: Preliminary Reports from a Single-Centre Retrospective Analysis.","authors":"Xintao Cai, Dingting Wang, Huajun Feng, Shengen Xu, Fei Li, Weihua Zhou, Gang Qin","doi":"10.1186/s12957-025-03854-7","DOIUrl":"10.1186/s12957-025-03854-7","url":null,"abstract":"<p><strong>Objectives: </strong>This study investigated the characteristics and clinical efficacy of transoral endoscopy-assisted low-temperature plasma surgery for the treatment of oropharyngeal malignant tumours.</p><p><strong>Methods: </strong>The clinical data of 14 patients who underwent transoral endoscopy-assisted low-temperature plasma resection of oropharyngeal malignant tumours in the Department of Otolaryngology-Head and Neck Surgery from January 2017 to October 2024 were retrospectively analysed. The general characteristics, clinical pathology results, surgical methods, operative time, volume of blood loss, length of hospitalization, and follow-up status of the patients were analysed.</p><p><strong>Results: </strong>The 14 patients included 13 males and 1 female, and the average age was 60 ± 9 years. Three patients received flaps for wound repair (1 forearm flap, 1 platysma myocutaneous flap, and 1 submental flap), 6 patients underwent unilateral neck lymph node dissection, 5 patients underwent bilateral neck lymph node dissection, and 1 patient underwent preventive tracheotomy. The average duration of the operations was 231 ± 114 min, and the average duration of tumour resection was 53 ± 15 min. The average volume of blood loss was 66 ± 55 ml, and the average duration of hospitalization was 10 ± 5 days. Postoperative pathology confirmed that 13 patients had squamous cell carcinoma, and 1 patient had mucoepidermoid carcinoma. The average duration of postoperative follow-up was 20 ± 14 months. One patient developed multisystem metastases, and one patient experienced tumour recurrence. all other patients survived well.</p><p><strong>Conclusions: </strong>Transoral surgery has become more common as a minimally invasive approach for treating oropharyngeal tumours. Transoral endoscopy-assisted low-temperature plasma-assisted resection of oropharyngeal malignant tumours may be used as a surgical approach.</p>","PeriodicalId":23856,"journal":{"name":"World Journal of Surgical Oncology","volume":"23 1","pages":"202"},"PeriodicalIF":2.5,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12100998/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144133085","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Modified overlap SMAS flap in the treatment of facial depression after resection of benign parotid lesions.","authors":"Zhen Yu, Wenxing Xun, Pan Ren, Fuxin Ma, Yongqian Bian, Congying Zhao, Jinqing Li","doi":"10.1186/s12957-025-03862-7","DOIUrl":"10.1186/s12957-025-03862-7","url":null,"abstract":"<p><strong>Objective: </strong>The purpose of our study was to evaluate the clinical effect of a facelift combined with a modified overlapping superficial musculoaponeurotic system (SMAS) flap for repairing facial depression caused by the resection of benign parotid lesions.</p><p><strong>Methods: </strong>This retrospective, non-randomized observational study included 87 patients diagnosed with benign parotid tumors who underwent surgical treatment between June 2014 and September 2023. All patients were treated in our department or by the same surgical team after institutional transfer. All patients received surgery via a standardized facelift incision approach.; All patients underwent surgery using a standardized facelift incision. Of them, 58 patients received reconstructive surgery with the modified SMAS flap, and 29 patients were treated using the classical SMAS flap. The degree of satisfaction with scarring and facial depression was assessed 6 months postoperatively using the Vancouver Scar Scale (VSS) and a 10-point scale (0 = no obvious depression; 10 = severe depression), respectively.</p><p><strong>Results: </strong>There was no significant difference regarding the degree of satisfaction with scarring between the two groups (P > 0.05), while the modified SMAS flap group was significantly more satisfied with the facial depressions than the classical SMAS flap group (P < 0.001). Surgical complications and tumor recurrence were not significantly different between the two groups.</p><p><strong>Conclusions: </strong>A facelift combined with a modified SMAS flap can effectively repair the facial depressions caused by the resection of benign parotid lesions and achieve good aesthetic results.</p>","PeriodicalId":23856,"journal":{"name":"World Journal of Surgical Oncology","volume":"23 1","pages":"201"},"PeriodicalIF":2.5,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12100780/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144132951","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analysis of the current situation and risk factors of nosocomial infections in oral cancer patients after surgery.","authors":"Aimin Zhang, Lurui Yu, Xiaoli Wang, Xiaofang Huang, Tao Zhang, Xianghao Kong, Xiaohui Chi","doi":"10.1186/s12957-025-03836-9","DOIUrl":"10.1186/s12957-025-03836-9","url":null,"abstract":"<p><strong>Background: </strong>To investigate the current situation of nosocomial infections in oral cancer patients after surgery, explore possible risk factors for nosocomial infections, screen high-risk populations for nosocomial infections after oral cancer surgery in the early stage, and provide scientific basis for the prevention and control of nosocomial infections in oral cancer patients after surgery.</p><p><strong>Methods: </strong>201 patients with oral cancer who underwent surgery in the Department of Oral and Maxillofacial Surgery of our hospital from January 2019 to December 2023 were collected, and their clinical data were observed. Statistics on the incidence of nosocomial infections, infection sites, and pathogenic bacteria in patients undergoing oral cancer surgery. Through univariate analysis and multivariate logistic regression analysis, identify the risk factors for nosocomial infections in oral cancer patients after surgery.</p><p><strong>Results: </strong>This study included 201 patients undergoing oral cancer surgery, with 24 cases of nosocomial infections and a nosocomial infection rate of 11.91%. Surgical incision infection is the most common site of infection, accounting for 45.83%, followed by pulmonary infection, accounting for 33.33%. Through pathogen examination, a total of 22 strains of pathogens were found, including 14 Gram negative bacteria (63.64%) and 7 Gram positive bacteria (31.82%). The univariate analysis found that 11 items included: smoking history, drinking history, diabetes, operation duration, skin flap repair, intraoperative bleeding, preventive use of antibiotics, tracheal intubation, gastric tube retention time, venous thromboembolism on the operation day, preoperative oral scaling, which may be the risk factors for nosocomial infection after oral cancer surgery. Logistic regression analysis showed that six independent risk factors of nosocomial infection after oral cancer surgery included: diabetes, skin flap repair, intraoperative bleeding, tracheal intubation, gastric tube retention time, and venous thromboembolism on the day of operation.</p><p><strong>Conclusion: </strong>Oral cancer surgery patients are at high risk of infection, and targeted monitoring of oral cancer surgery patients should be strengthened. Preventive measures should be taken for risk factors to reduce nosocomial infection rates.</p>","PeriodicalId":23856,"journal":{"name":"World Journal of Surgical Oncology","volume":"23 1","pages":"197"},"PeriodicalIF":2.5,"publicationDate":"2025-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12096623/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144128904","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Concurrent SMARCA4-deficient and poorly differentiated adenocarcinomas in separate lung lobes: a case report and literature review.","authors":"Lu Wang, Yeqin Wu, Liqian Hu, Gangping Wang","doi":"10.1186/s12957-025-03839-6","DOIUrl":"10.1186/s12957-025-03839-6","url":null,"abstract":"<p><strong>Background: </strong>SMARCA4 and SMARCA2, mutually exclusive catalytic ATPase subunits of human mammalian Switch/Sucrose-Nonfermentable chromatin remodeling enzymes, function as tumor suppressor genes. SMARCA4-deficient adenocarcinoma (SMARCA4-dADC) is a relatively rare subtype of TTF1/P40-negative non-small cell lung cancer. The concurrent presentation of SMARCA4-dADC and poorly differentiated adenocarcinoma with SMARCA2 (also known as BRM) loss in separate lobes of the same patient is even less common. This report describes such a case involving the simultaneous occurrence of these two tumor types in distinct locations within the lungs.</p><p><strong>Case presentation: </strong>A 68-year-old male presented with a three-week history of vague pain in the right side of the chest, with no obvious trigger. Imaging revealed solid masses in the upper and lower lobes of the right lung with bilateral enlarged cervical lymph nodes. So, both of these masses underwent wedge resection. Histopathological examination confirmed that the lower lobe tumor was SMARCA4-dADC, while the upper lobe tumor was diagnosed as poorly differentiated adenocarcinoma. Although histologically similar, both exhibiting predominantly solid sheets and complex glandular structures, the two tumors displayed distinct immunohistochemical and molecular profiles. The lower lobe mass showed complete loss of BRG1 protein expression and partial loss of BRM. Immunohistochemical analysis revealed negative expression of TTF1, Napsin A, SALL4, CD34, and SOX2, and positive expression of CK7, pan-Cytokeratin (CK-pan), and HepPar-1. Molecular analysis identified mutations in SMARCA4, KRAS, and STK11. Conversely, the upper lobe mass retained BRG1 expression but showed complete loss of BRM protein expression, and negative expression of SALL4, CD34, and HepPar-1, positive expression of CK7, CK-pan, TTF1, Napsin A, and SOX2. A KRAS mutation was also detected in this tumor.</p><p><strong>Conclusion: </strong>The simultaneous occurrence of SMARCA4-dADC and conventional adenocarcinoma in different locations within the same patient is exceedingly rare. However, the distinct immunophenotypic and molecular characteristics of SMARCA4-dADC differentiate it as a unique entity from conventional adenocarcinoma. We recommend including SMARCA4 in the marker panel used to evaluate TTF1-negative adenocarcinomas of potential or uncertain pulmonary origin. This report underscores the diagnostic challenge of concurrent SMARCA4-dADC and poorly differentiated adenocarcinoma, proposing a standardized immunohistochemical workflow to guide therapeutic decisions.</p>","PeriodicalId":23856,"journal":{"name":"World Journal of Surgical Oncology","volume":"23 1","pages":"198"},"PeriodicalIF":2.5,"publicationDate":"2025-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12096594/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144128913","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predictive value of machine learning for PD-L1 expression in NSCLC: a systematic review and meta-analysis.","authors":"Ting Zheng, Xingxing Li, Li Zhou, Jianjiang Jin","doi":"10.1186/s12957-025-03847-6","DOIUrl":"10.1186/s12957-025-03847-6","url":null,"abstract":"<p><strong>Background: </strong>As machine learning (ML) continuously develops in cancer diagnosis and treatment, some researchers have attempted to predict the expression of programmed death ligand-1 (PD-L1) in non-small cell lung cancer (NSCLC) by ML. However, there is a lack of systematic evidence on the effectiveness of ML.</p><p><strong>Methods: </strong>We conducted a thorough search across Embase, PubMed, the Cochrane Library, and Web of Science from inception to December 14th, 2023.A systematic review and meta-analysis was conducted to assess the value of ML for predicting PD-L1 expression in NSCLC.</p><p><strong>Results: </strong>Totally 30 studies with 12,898 NSCLC patients were included. The thresholds of PD-L1 expression level were < 1%, 1-49%, and ≥ 50%. In the validation set, in the binary classification for PD-L1 ≥ 1%, the pooled C-index was 0.646 (95%CI: 0.587-0.705), 0.799 (95%CI: 0.782-0.817), 0.806 (95%CI: 0.753-0.858), and 0.800 (95%CI: 0.717-0.883), respectively, for the clinical feature-, radiomics-, radiomics + clinical feature-, and pathomics-based ML models; in the binary classification for PD-L1 ≥ 50%, the pooled C-index was 0.649 (95%CI: 0.553-0.744), 0.771 (95%CI: 0.728-0.814), and 0.826 (95%CI: 0.783-0.869), respectively, for the clinical feature-, radiomics-, and radiomics + clinical feature-based ML models.</p><p><strong>Conclusions: </strong>At present, radiomics- or pathomics-based ML methods are applied for the prediction of PD-L1 expression in NSCLC, which both achieve satisfactory accuracy. In particular, the radiomics-based ML method seems to have wider clinical applicability as a non-invasive diagnostic tool. Both radiomics and pathomics serve as processing methods for medical images. In the future, we expect to develop medical image-based DL methods for intelligently predicting PD-L1 expression.</p>","PeriodicalId":23856,"journal":{"name":"World Journal of Surgical Oncology","volume":"23 1","pages":"199"},"PeriodicalIF":2.5,"publicationDate":"2025-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12101016/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144128914","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Optimized prosthetic design, surgical technique, and cosmetic outcome in shoulder reconstruction with double-constrained implant following extra-articular shoulder resection: a proof-of-concept.","authors":"Jan Lesensky, Michal Benes, Martin Havranek, Ana C Belzarena","doi":"10.1186/s12957-025-03844-9","DOIUrl":"10.1186/s12957-025-03844-9","url":null,"abstract":"<p><p>Reconstruction of the anatomic defect following extra-articular shoulder resection is a challenging problem, particularly in cases when function of the deltoid muscle and rotator cuff are compromised. Standard reconstruction techniques often result in either instability or rigidity. Constrained implants have been used to overcome these problems; however, they have been associated with a high rate of aseptic loosening. Recently, a novel double-constrained implant has been introduced, yielding promising functional results. Nonetheless, this implant exhibited a cosmetic defect related to protrusion of the humeral component that becomes apparent with time as result of surrounding muscle atrophy. An updated improved design of the implant has been developed to counteract this.We report the case of a 15-year-old patient who underwent an extra-articular (Malawer type V) shoulder resection due to osteosarcoma and received an innovated custom-made double-constrained implant. Moreover, we describe a new modification of the Malawer utilitarian approach to the shoulder girdle that enhances tumor visibility and allows safer dissection. The patient recovered well with satisfactory outcomes at 18 months follow-up, highlighting the potential benefits of this implant design and surgical approach.</p>","PeriodicalId":23856,"journal":{"name":"World Journal of Surgical Oncology","volume":"23 1","pages":"194"},"PeriodicalIF":2.5,"publicationDate":"2025-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12083034/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144086853","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prognostic and clinicopathological value of fibrinogen-to-albumin ratio in non-small cell lung cancer: a meta-analysis.","authors":"Ling Tong, Hui Hu, Jiashan Li, Lihai Pan","doi":"10.1186/s12957-025-03832-z","DOIUrl":"10.1186/s12957-025-03832-z","url":null,"abstract":"<p><strong>Background: </strong>The fibrinogen-to-albumin ratio (FAR) has been explored for its role in predicting non-small cell lung cancer (NSCLC) prognosis, but findings remain inconsistent. This study aimed to determine the exact impact of FAR on predicting NSCLC prognosis through a meta-analysis.</p><p><strong>Methods: </strong>This study conducted a comprehensive search of PubMed, Web of Science, Embase, Cochrane Library, and CNKI up to April 2, 2025, and determined pooled hazard ratios (HRs) and 95% confidence intervals (CIs) to evaluate the prognostic value of FAR in NSCLC.</p><p><strong>Results: </strong>This meta-analysis included seven studies with a total of 2,655 cases. The pooled analysis revealed that an elevated FAR significantly predicted poor overall survival (OS) (HR = 1.82, 95% CI = 1.56-2.14, p < 0.001) and poor progression-free survival (PFS) (HR = 1.50, 95% CI = 1.29-1.74, p < 0.001) in patients with NSCLC, which was strongly associated with male sex (OR = 1.53, 95% CI = 1.12-2.08, p = 0.008) and tumor size ≥ 5 cm (OR = 1.52, 95% CI = 1.08-2.14, p = 0.017). However, FAR showed no significant correlation with smoking history (OR = 1.44, 95% CI = 0.80-2.59, p = 0.218) or Eastern Cooperative Oncology Group performance status (OR = 1.60, 95% CI = 0.74-3.45, p = 0.230).</p><p><strong>Conclusion: </strong>This meta-analysis suggests that elevated FAR is a strong predictor of OS and PFS in patients with Chinese NSCLC and correlates with larger tumor size.</p>","PeriodicalId":23856,"journal":{"name":"World Journal of Surgical Oncology","volume":"23 1","pages":"196"},"PeriodicalIF":2.5,"publicationDate":"2025-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12082923/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144086854","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The association of immune-inflammation indices at multiple time points with treatment response and survival in advanced non-small cell lung cancer patients receiving immune checkpoint inhibitors.","authors":"Yaqing Li, Jianping Xu, Lijuan Zhang, Zhigang Cai","doi":"10.1186/s12957-025-03833-y","DOIUrl":"10.1186/s12957-025-03833-y","url":null,"abstract":"<p><strong>Background: </strong>Immune and inflammation participate in the progression of non-small cell lung cancer (NSCLC) and some immune-inflammation indexes may serve as prognostic biomarkers in NSCLC patients. This study aimed to investigate the association between immune-inflammation indices at multiple time points and prognosis in advanced NSCLC patients treated with immune checkpoint inhibitors (ICIs).</p><p><strong>Methods: </strong>This retrospective study included 102 advanced NSCLC patients treated with ICIs and collected their blood indices within 7 days before treatment (T1), before the 3rd treatment cycle (T2), and before the 5th treatment cycle (T3) to calculate neutrophil-to-lymphocyte ratio (NLR), derived neutrophil-to-lymphocyte ratio (dNLR), pan-immune-inflammatory value (PIV), systemic immune-inflammation index (SII), prognostic nutritional index (PNI), and lung immune prognostic index (LIPI).</p><p><strong>Results: </strong>dNLR (P = 0.006), SII (P = 0.005), PIV (P = 0.010), and LIPI (P = 0.001) reduced, while PNI increased (P = 0.009) from T1 to T3; NLR was not different among T1, T2, and T3 (P = 0.282). A lower NLR (P = 0.011) and higher PNI (P = 0.026) at T3, and lower LIPI at T2 (P = 0.023) were related to better disease control rate, but these immune-inflammation indices were not linked with objective response rate at any timepoint. Multivariate Cox regression analysis showed that high NLR at T1 was independently related to worse PFS (hazard ratio: 4.187, P = 0.008), while high PNI at T3 was independently associated with better PFS (hazard ratio: 0.454, P = 0.021).</p><p><strong>Conclusion: </strong>NLR before and after treatment, as well as PNI and LIPI after treatment may serve as potential biomarkers for treatment response or survival in advanced NSCLC patients receiving ICIs.</p>","PeriodicalId":23856,"journal":{"name":"World Journal of Surgical Oncology","volume":"23 1","pages":"195"},"PeriodicalIF":2.5,"publicationDate":"2025-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12082983/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144086856","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}