World Journal of Surgical Oncology最新文献

{"title":"Predictive factors for failure in patients with N1b papillary thyroid carcinoma.","authors":"Margulis Itai, Gordon Yonathan, Stein Nili, Doweck Ilana","doi":"10.1186/s12957-025-03694-5","DOIUrl":"https://doi.org/10.1186/s12957-025-03694-5","url":null,"abstract":"<p><strong>Background: </strong>This study aimed to evaluate predictive factors for failure in patients with N1b papillary thyroid carcinoma.</p><p><strong>Methods: </strong>This retrospective study included patients presenting with lymph node metastases of papillary thyroid carcinoma in the lateral neck, and treated by thyroidectomy, central and lateral neck dissection in the Department of Otolaryngology, Head and Neck Surgery at Carmel Medical Center, between 2008-2021.</p><p><strong>Results: </strong>Ninety-seven patients underwent 104 neck dissections. The mean age was 48 ± 18.8 years; 56 (57%) were women. The mean follow-up was 84.5 ± 48.3 months. Total nodal yield and the number of positive nodes were both inversely correlated with age (p < 0.0001). Twenty patients (21%) had treatment failure. Age (p = 0.0039), the number of positive nodes (p = 0.0042), extracapsular extension (p = 0.0085), and positive margins (p = 0.015) were predictors for failure in univariate and multivariate analyses. Among patients aged > 55 years, failures were more common (p = 0.024) and recurrence-free survival was significantly lower (p = 0.0044). Five- and ten-year disease specific survival rates were 96% and 85%, respectively. The age cutoff of 55 years predicted survival.</p><p><strong>Conclusions: </strong>Age, positive margins, number of positive nodes in neck dissection, and extracapsular extension correlated with treatment failure in clinical lateral neck nodal metastasis of papillary thyroid carcinoma. The number of positive nodes in neck dissection and the total nodal yield decreased with age. Patients with advanced regional disease at presentation, aged ≤ 55, have reduced risk for failure and better RFS, DSS and overall survival compared to patients aged >55 years.</p>","PeriodicalId":23856,"journal":{"name":"World Journal of Surgical Oncology","volume":"23 1","pages":"307"},"PeriodicalIF":2.5,"publicationDate":"2025-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144761554","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Robotic versus open hepatectomy for large(≥ 5 cm) hepatocellular carcinoma: A large volume center, propensity score matched study.","authors":"Weimin Mao, Bingcheng Meng, Zongrui Jin, Banghao Xu, Jilong Wang, Zhujing Lan, Jingyuan Zhou, Tiansheng Lan, Tingting Lu, Ling Zhang, Rui Song, Zili Lv, Hai Zhu, Zhang Wen","doi":"10.1186/s12957-025-03914-y","DOIUrl":"https://doi.org/10.1186/s12957-025-03914-y","url":null,"abstract":"<p><strong>Background: </strong>Robotic hepatectomy is widely used to treat liver tumors. However, there are limited studies comparing robotic hepatectomy with conventional open hepatectomy for large (≥ 5 cm) hepatocellular carcinoma. This study aims to evaluate the perioperative and long-term outcomes of patients with large and huge hepatocellular carcinoma undergoing robotic or open hepatectomy.</p><p><strong>Methods: </strong>This retrospective study included patients with large hepatocellular carcinoma who underwent robotic hepatectomy or open hepatectomy by the same surgical team at the Department of Hepatobiliary Surgery, the First Affiliated Hospital of Guangxi Medical University, from January 2021 to January 2024. Propensity score matching (PSM) was used to minimize potential bias.</p><p><strong>Results: </strong>According to the predetermined inclusion criteria, this study included 96 open hepatectomy(OH) patients and 23 robotic hepatectomy (RH) patients. After PSM, two homogeneous groups (RH and OH, n = 23 each) were created. The RH group had less blood loss (median 100 ml vs. 300ml, P = 0.008) and a lower incidence of postoperative pulmonary complications (8.7% vs. 39.1%, P = 0.016) compared to the OH group. There were no statistically significant differences in overall survival (OS) and disease-free survival (DFS) between the two groups.</p><p><strong>Conclusion: </strong>For patients with large(≥ 5 cm) hepatocellular carcinoma, robotic hepatectomy provides a safe, feasible and less invasive approach for treatment.</p>","PeriodicalId":23856,"journal":{"name":"World Journal of Surgical Oncology","volume":"23 1","pages":"306"},"PeriodicalIF":2.5,"publicationDate":"2025-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144761559","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of primary tumor location in the basal segment or superior segment (S6) on patient survival in lung cancer: a meta-analysis.","authors":"Xuan Yu, Yanlong Yang, Xiaobo Chen, Sinuo Song, Xinghe Tong, Xudong Yang","doi":"10.1186/s12957-025-03945-5","DOIUrl":"https://doi.org/10.1186/s12957-025-03945-5","url":null,"abstract":"<p><strong>Background: </strong>Among the key factors influencing the prognosis of lung cancer, the primary tumor site has garnered significant attention in recent years, as it may affect the surgical difficulty and the risk of lymph node metastasis, thereby impacting overall prognosis. Numerous retrospective studies have produced conflicting conclusions, highlighting the necessity for a meta-analysis to consolidate these findings and ascertain the effects of primary tumor location in the basal versus superior segment of the lower lobe(S6) on survival outcomes.</p><p><strong>Methods: </strong>We conducted a comprehensive literature search up to January 2025 and identified six relevant retrospective studies. We then used the random-effects model in Stata software to perform a meta-analysis to evaluate the impact of the primary tumor location on overall survival(OS) and event-free survival(EFS), EFS was defined as an aggregate of freedom from recurrence (FFR), disease-free survival (DFS), and progression-free survival (RFS).</p><p><strong>Result: </strong>This study demonstrated that there were no statistically significant differences in OS (S6 vs. Basal segment HR = 1.40, 95% CI: 0.81,2.42 I²=71.8%) and EFS(S6 vs. Basal segment HR = 1.32, 95% CI: 0.69,2.54, I²=76.6%) between patients with the tumor in the S6 segment or basal segment. Begg's test did not find publication bias (p > 0.05). Subgroup analysis indicated that the year of publication, clinical stage, sample size, and both univariate and multivariate analyses did not significantly influence the results.</p><p><strong>Conclusion: </strong>The direct impact of tumor location (S6 vs. Basal segment)on survival is not statistically significant.</p>","PeriodicalId":23856,"journal":{"name":"World Journal of Surgical Oncology","volume":"23 1","pages":"309"},"PeriodicalIF":2.5,"publicationDate":"2025-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144761553","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The adverse impact of early postoperative complications after liver transplantation on long-term prognosis in patients with hepatocellular carcinoma.","authors":"Jiayi Zhang, Mingxi Zhang, Xiaorui Liu, Zehua Jia, Jingxing Zhang, Yunhua Tang, Tielong Wang, Xiaoshun He","doi":"10.1186/s12957-025-03919-7","DOIUrl":"https://doi.org/10.1186/s12957-025-03919-7","url":null,"abstract":"","PeriodicalId":23856,"journal":{"name":"World Journal of Surgical Oncology","volume":"23 1","pages":"308"},"PeriodicalIF":2.5,"publicationDate":"2025-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144761560","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ctDNA methylation profiling reveals NBL1 as a promising biomarker for early ovarian cancer screening.","authors":"Shunxian Zhou, Huan Yin, Lei Yan, Nian Xie, Chun Fu","doi":"10.1186/s12957-025-03957-1","DOIUrl":"10.1186/s12957-025-03957-1","url":null,"abstract":"<p><strong>Background: </strong>Early detection of epithelial ovarian cancer (EOC) is crucial for improving patient survival. Current screening methods have limitations, highlighting the need for novel biomarkers. Circulating tumor DNA (ctDNA) methylation analysis offers a promising approach.</p><p><strong>Methods: </strong>This study included 10 patients with EOC and 10 patients with benign pelvic masses. We collected plasma samples from these patients and isolated ctDNA. We then conducted whole-genome methylation sequencing using the TAPS (TET-assisted pyridine borane sequencing) method, which allows for single-base resolution detection of 5-methylcytosine and 5-hydroxymethylcytosine. Bioinformatics analysis was performed to identify differentially methylated genes and regions. We further validated candidate biomarkers using bisulfite sequencing, qRT-PCR, and IHC. TCGA methylation data were analyzed for external validation.</p><p><strong>Results: </strong>We identified 35 differentially methylated genes, with NBL1 and CASZ1 as potential candidates. NBL1 gene hypermethylation in EOC patients was significantly associated with reduced mRNA expression, suggesting its role as a tumor suppressor gene. CASZ1 methylation patterns were inconsistent between blood and tissue, indicating limited utility as a diagnostic biomarker. We also observed widespread hypo-methylation across the genome and hyper-methylation in specific regions of differential methylation. GO and KEGG pathway enrichment analyses revealed that the differentially methylated genes were involved in various biological processes and pathways relevant to cancer pathogenesis. There is a significant negative correlation between the methylation level and the mRNA level of the NBL1 gene, suggesting that hypermethylation of the NBL1 gene may be associated with a reduction in its expression. Furthermore, immunohistochemical analysis indicates a downregulation of NBL1 expression in ovarian cancer tissues, which contrasts with the strong positive expression observed in benign tissues.</p><p><strong>Conclusion: </strong>Our study demonstrates the potential of ctDNA methylation analysis for early EOC detection. we propose that NBL1 gene hold potential as screening biomarkers for ovarian cancer.</p>","PeriodicalId":23856,"journal":{"name":"World Journal of Surgical Oncology","volume":"23 1","pages":"305"},"PeriodicalIF":2.5,"publicationDate":"2025-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12302688/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144733468","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Global, regional, and national burden and trends of prostate cancer in elderly from 1990 to 2021: results from global burden of disease 2021.","authors":"Yinghong Li, Mingjie Tang, Jun Shao, Shiwei Li, Yuhao Teng, Yuanyuan Xu, Peng Shu","doi":"10.1186/s12957-025-03937-5","DOIUrl":"10.1186/s12957-025-03937-5","url":null,"abstract":"<p><strong>Background: </strong>Emerging evidence has demonstrated marked geographical and demographic variations in prostate cancer (PC) incidence and mortality rates. As PC predominantly affects the elderly, in-depth analysis of disease trends in this vulnerable population is imperative.</p><p><strong>Methods: </strong>This study leveraged data from the Global Burden of Disease Study (GBD) 2021 to systematically evaluate temporal trends in the incidence, mortality, and Disability-Adjusted Life Years (DALYs) of PC in elderly aged 70 and above. The analyses were stratified by age group, geographic region, and Socio-demographic Index (SDI) quintiles. Furthermore, this study employed a comprehensive analytical approach, including estimated annual percentage change (EAPC), decomposition analysis, and predictive modeling (Nordpred method).</p><p><strong>Results: </strong>From 1990 to 2021, the burden of PC in elderly exhibited a substantial rise, with incident cases, mortality cases, and DALYs all demonstrating significant increases. In 2021, the global age-standardized rates for incidence (ASIR), mortality (ASMR), and DALYs (ASDALYR) were 348.8 (95% uncertainty interval [UI]: 310.75 to 375.79), 177.93 (95% UI: 152.84 to 194.06) and 2513.84 (95% UI: 2170.81 to 2749.77) per 100,100, respectively. Geographically, the highest persistent burden was observed in High Income North America, Australasia, and high SDI region. Most regions were positively correlated with the SDI. The highest incidences of PC in elderly were in the 95 + age group. Decomposition analysis showed that the increase in burden indicators of PC in elderly globally and in the five SDI regions was mainly caused by population growth. Nordpred analysis predicts slight decline in ASIR, ASMR, and ASDALYR by 2046.</p><p><strong>Conclusion: </strong>Our analysis unveils a considerable and relentlessly escalating global PC burden among the elderly, with striking geographical heterogeneity. These data underscore the pressing need for tailored public health strategies to mitigate the burgeoning impact of PC in the worldwide aging populace.</p>","PeriodicalId":23856,"journal":{"name":"World Journal of Surgical Oncology","volume":"23 1","pages":"303"},"PeriodicalIF":2.5,"publicationDate":"2025-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12297840/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144718759","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"HER2 mutations in pulmonary adenocarcinoma presenting with ground-glass nodules.","authors":"Jiacheng Yin, Shuhua Huo, Zhencong Chen, Yu Shi, Qihai Sui, Qun Wang, Jiangjiang Xu, Wei Jiang","doi":"10.1186/s12957-025-03955-3","DOIUrl":"10.1186/s12957-025-03955-3","url":null,"abstract":"<p><strong>Background: </strong>Human epidermal growth factor receptor 2 (HER2) mutations have been identified as oncogenic drivers and therapeutic targets in Non-small cell lung cancers (NSCLCs). The role of HER2 mutation in lung adenocarcinoma presented as sub-solid nodules (SSNs) have not been distinctly defined. This study comprehensively investigated the clinicopathological characteristics of HER2 mutation in patients with pulmonary SSNs.</p><p><strong>Methods: </strong>In total, 717 patients with completely resected NSCLCs presented as SSNs were examined for HER2 mutation from January 2016 to December 2018. Age, sex, smoking history, radiologic features, operative procedure, pleural invasion, histologic subtypes and tumor-node-metastasis stage were collected. Kaplan-Meier method was used to estimate DFS, Log-rank test was used to compare the survival data. Logistic regression model was used to identify the predictors for HER2 mutation and the predictive nomogram was built.</p><p><strong>Results: </strong>In this study, 47(6.6%) SSNs carried HER2 mutations. HER2 mutations were more frequent in subjects with younger age (P < 0.001) and smaller tumor size (P < 0.001), and were prone to occur in AIS and MIA (P < 0.001). The 5- year DFS rates for HER2 mutation and HER2 wild-type groups were similar (P = 0.509). According to the logistic regression analysis, age and maximum tumor size were independent variables correlated with HER2 mutation. A predictive nomogram model was constructed with a concordance statistic of 0.79 (0.71-0.87).</p><p><strong>Conclusions: </strong>HER2 mutation was not uncommon in pulmonary SSNs. Younger age and smaller tumor size were associated with increased odds of HER2 mutation.</p>","PeriodicalId":23856,"journal":{"name":"World Journal of Surgical Oncology","volume":"23 1","pages":"304"},"PeriodicalIF":2.5,"publicationDate":"2025-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12297846/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144718760","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A SEER-based prognostic nomogram for early-stage (pT1-2N0M0) tongue squamous cell carcinoma and an observational analysis of postoperative radiotherapy.","authors":"Dandan Lin, Huling Li, Xing Feng, Yang Zhang, Dandan Tang, Kai Wang","doi":"10.1186/s12957-025-03883-2","DOIUrl":"10.1186/s12957-025-03883-2","url":null,"abstract":"<p><strong>Background: </strong>To develop a nomogram for predicting overall survival (OS) and cancer-specific survival (CSS) in patients with postoperative early-stage (pT1-2N0M0) tongue squamous cell carcinoma (TSCC), and to explore the association between postoperative radiotherapy (PORT) and patient survival.</p><p><strong>Methods: </strong>Data from 7,637 patients with pT1-2N0M0 TSCC who underwent surgery between 2000 and 2021 were extracted from the SEER database. Patients were randomly divided into a training cohort and a validation cohort in a 2:1 ratio. Prognostic factors were identified via Kaplan-Meier analysis and Cox regression, and a nomogram was constructed. To minimize confounding, propensity score matching (PSM) was used to compare outcomes between patients who received PORT and those who did not. Subgroup and interaction analyses were performed to assess potential effect modifiers.</p><p><strong>Results: </strong>Of the 7,637 patients included, 1,336 (17.5%) received PORT. Multivariate Cox analysis identified age, race, marital status, grade, tumor size, lymph node (LN) removed status, and PORT as independent prognostic factors for OS and CSS. The nomogram demonstrated strong predictive performance based on time-dependent ROC curves, concordance indices, calibration plots, and decision curve analyses in both training and validation cohorts. After PSM, PORT remained associated with worse OS and CSS. Subgroup analyses revealed that the association between PORT and poorer OS was most evident in younger patients, married individuals, T1 stage patients, those with smaller tumors, and those without LN removal, with racial disparities also observed. For CSS, this association was more pronounced in married individuals, well-differentiated patients, T1 stage patients, those with smaller tumors, and those without LN removal.</p><p><strong>Conclusion: </strong>The SEER-based nomogram provides survival predictions for postoperative pT1-2N0M0 TSCC patients. Although PORT was associated with worse survival in several subgroups, findings should be cautiously interpreted given the observational design and absence of key clinical variables (PNI, LVI, surgical margins). Prospective studies incorporating comprehensive clinicopathological data are warranted to confirm associations and guide individualized PORT decisions in early-stage TSCC patients.</p>","PeriodicalId":23856,"journal":{"name":"World Journal of Surgical Oncology","volume":"23 1","pages":"302"},"PeriodicalIF":2.5,"publicationDate":"2025-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12291312/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144718758","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Characteristics and prognosis of skip lymph node metastasis in gastric cancer: a retrospective study.","authors":"Kuang-Hua Lo, Kuo-Hung Huang, Wen-Liang Fang, Shih-Chieh Lin, Yi-Ping Hung, Ming-Huang Chen, Chew-Wen Wu, Ching-Yun Kung","doi":"10.1186/s12957-025-03951-7","DOIUrl":"10.1186/s12957-025-03951-7","url":null,"abstract":"<p><strong>Background: </strong>Lymph node dissection is a standardized procedure in gastric cancer surgery. Typically, lymph node metastasis begins in the perigastric (PG) region and then extends to the extraperigastric (EP) region. However, in some circumstances, skip lymph node metastasis occurs in the EP region without involvement of the PG lymph nodes. This study aims to investigate the clinical significance of skip lymph node metastasis in gastric cancer.</p><p><strong>Methods: </strong>A total of 1,055 patients who underwent curative gastrectomy for primary gastric cancer with pathological lymph node metastasis were analyzed. Patients were categorized into three groups: the PG-only group, the PG + EP group, and the skip group. The clinicopathologic characteristics and prognosis were analyzed.</p><p><strong>Results: </strong>The incidence of skip lymph node metastasis was 3.9% (41 of 1,055 patients). The skip group had a higher proportion of females compared to both the PG-only group (43.9% vs. 27.5%, p = 0.025) and the PG + EP group (43.9% vs. 26.5%, p = 0.017). Additionally, the skip group showed a higher proportion of intestinal-type tumors compared to the PG-only group (68.3% vs. 50.6%, p = 0.029) and the PG + EP group (68.3% vs. 40.2%, p = 0.001). Disease-free survival and overall survival in the skip group were similar to those in the PG-only group but significantly better than those in the PG + EP group.</p><p><strong>Conclusions: </strong>Skip lymph node metastasis is uncommon, and it is associated with a higher proportion of females and intestinal-type tumors. The prognosis of the skip group was comparable to the PG-only group and significantly better than that of the PG + EP group.</p>","PeriodicalId":23856,"journal":{"name":"World Journal of Surgical Oncology","volume":"23 1","pages":"301"},"PeriodicalIF":2.5,"publicationDate":"2025-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12291338/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144709165","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Is the tail of the pancreas always tumor-infiltrated when macroscopically affected during cytoreductive surgery? A clinicopathological study and experience from a high-volume center.","authors":"Miklos Acs, Jozef Zustin, Niklas Bogovic, Pompiliu Piso, Sebastian Blaj","doi":"10.1186/s12957-025-03954-4","DOIUrl":"10.1186/s12957-025-03954-4","url":null,"abstract":"<p><strong>Background: </strong>Distal pancreatic resection during cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) is rare, with limited knowledge available. Therefore, a retrospective observational study was conducted using the data registry of a single institution to identify patients that underwent distal pancreatic resection during CRS + HIPEC.</p><p><strong>Methods: </strong>All resected pancreatic specimens were examined for invasive parenchymal tumor infiltration. Pre-, peri-, and postoperative variables and their associations were analyzed.</p><p><strong>Results: </strong>Over a period of more than a decade, 31 of 1275 patients (2.43%) underwent distal pancreatic resection as part of CRS. Infiltration of the pancreatic parenchyma was confirmed in almost one-third (29.03%) of the cases. Postoperative pancreatic fistulas occurred in 25.81% of patients (87.5% Grade B; 12.5% Grade C). The need for distal pancreatic resection was closely related to tumor burden in the left upper abdomen, with 87% of patients requiring peritonectomy of the left upper abdomen in addition to visceral resection. Pancreatic infiltration (n = 9/31) was diagnosed in 3 cases of gastric carcinoma, 2 cases of colorectal carcinoma, 2 cases of primary peritoneal carcinoma, 1 case of ovarian carcinoma, and 1 case of mucinous appendiceal carcinoma. Postoperative pancreatic fistulas were more frequently associated with primary tumors of the large intestine (87.50% vs. 30.43%; P = 0.0094), and a tendentiously longer total hospital stay was required for the \"with pancreatic fistula\" group (32.50 ± 19.93 days vs. 21.78 ± 10.14 days), with no impact on patient survival.</p><p><strong>Conclusions: </strong>Accepting a slightly increased morbidity, distal pancreatic resection is a reasonable approach to achieve complete macroscopic tumor resection. Nonetheless, our study shows that apparent tumor invasion is histologically rare in cases with favorable tumor biology, such as low-grade pseudomyxoma peritonei. Therefore, pancreatic resection should be avoided in cases of mucinous tumors to prevent fistula formation.</p>","PeriodicalId":23856,"journal":{"name":"World Journal of Surgical Oncology","volume":"23 1","pages":"300"},"PeriodicalIF":2.5,"publicationDate":"2025-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12291515/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144709166","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}