World Journal of Surgical Oncology最新文献

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Successful treatment of osimertinib-resistant EGFR-mutant NSCLC with acquired BRAF V600E mutation using triple combination therapy: a case report with pathological confirmation. 三联疗法成功治疗奥西替尼耐药egfr突变NSCLC获得性BRAF V600E突变1例病理证实
IF 2.5 3区 医学
World Journal of Surgical Oncology Pub Date : 2025-10-10 DOI: 10.1186/s12957-025-04011-w
MingHui Lin, XuYu Chen, Fan Lin, YanBo Yang
{"title":"Successful treatment of osimertinib-resistant EGFR-mutant NSCLC with acquired BRAF V600E mutation using triple combination therapy: a case report with pathological confirmation.","authors":"MingHui Lin, XuYu Chen, Fan Lin, YanBo Yang","doi":"10.1186/s12957-025-04011-w","DOIUrl":"10.1186/s12957-025-04011-w","url":null,"abstract":"<p><strong>Background: </strong>Non-small cell lung cancer (NSCLC) with EGFR mutations often develops resistance to tyrosine kinase inhibitors (TKIs), with acquired BRAF V600E mutation being a rare but clinically challenging mechanism. The efficacy of combined EGFR and BRAF/MEK inhibition in this setting is not sufficiently characterized.</p><p><strong>Case presentation: </strong>A 56-year-old never-smoker with stage IVA EGFR exon 19del-mutant lung adenocarcinoma developed progressive disease on osimertinib, with a new BRAF V600E mutation detected via next-generation sequencing (NGS). She was treated with osimertinib (80 mg daily), dabrafenib (150 mg twice daily), and trametinib (2 mg daily), achieving: Radiological response: Regression of metastatic lesions (left lower lobe residual nodule) and stable disease in the primary lesion. Pathological confirmation: Post-surgical resection revealed only 1% residual tumor viability, indicating a major pathological response.</p><p><strong>Tolerability: </strong>Only grade 1 rash (CTCAE v5.0) was observed. Durable control: Progression-free survival (PFS) of 11 months (last follow-up: May 2025).</p><p><strong>Conclusion: </strong>Triple therapy with osimertinib, dabrafenib, and trametinib represents a viable and well-tolerated approach for EGFR-mutant NSCLC with acquired BRAFV600E resistance. Molecular profiling upon progression is essential to guide targeted therapy.</p>","PeriodicalId":23856,"journal":{"name":"World Journal of Surgical Oncology","volume":"23 1","pages":"365"},"PeriodicalIF":2.5,"publicationDate":"2025-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12512737/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145276022","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Young-onset versus late-onset colorectal cancer: clinicopathological features and survival outcome: a decade-long analysis from a middle Eastern tertiary center. 早发性与晚发性结直肠癌:临床病理特征和生存结果:来自中东三级中心长达十年的分析
IF 2.5 3区 医学
World Journal of Surgical Oncology Pub Date : 2025-10-09 DOI: 10.1186/s12957-025-04010-x
Ammar Aleter, Ali Toffaha, Ejaz Ahmed Latif, Mahwish Khawar, Ibrahim Amer, Samer A Hasan, Mahmood Al-Dhaheri, Ayman Ahmed, Ayman El-Menyar, Mohamed Abu Nada, Amjad Parvaiz
{"title":"Young-onset versus late-onset colorectal cancer: clinicopathological features and survival outcome: a decade-long analysis from a middle Eastern tertiary center.","authors":"Ammar Aleter, Ali Toffaha, Ejaz Ahmed Latif, Mahwish Khawar, Ibrahim Amer, Samer A Hasan, Mahmood Al-Dhaheri, Ayman Ahmed, Ayman El-Menyar, Mohamed Abu Nada, Amjad Parvaiz","doi":"10.1186/s12957-025-04010-x","DOIUrl":"10.1186/s12957-025-04010-x","url":null,"abstract":"<p><strong>Background: </strong>Colorectal cancer (CRC) incidence is reported to be declining overall in many countries but growing among young adults. The updated American Cancer Society (ACS) guidelines recommend screening starting at age 45 years. We sought to evaluate population-level trends in young colorectal cancer (yCRC) epidemiology in Qatar, a country in the Middle East.</p><p><strong>Methods: </strong>Between January 2010 and December 2020, we included 1529 patients from the National Registry Database with a 5-year follow-up. The patients were divided into two groups. Group 1 (n = 380, ≤ 45 years) and group 2 (n = 1149, > 45). The epidemiological and clinicopathological features were analyzed and compared in the two groups.</p><p><strong>Results: </strong>The annual incidence rate of CRC in Qatar from 2010 to 2020 ranged from 5.3 to 7.2 per 100,000 population, with an average of 5.79 per 100,000 population over this period. The overall prevalence among males was 65.6%. The incidence of CRC in young patients was approximately 1 in every four patients (24.8%). Males comprised almost two-thirds of the entire CRC cohort, yCRC, as well as the old-onset CRC cohort. The poorly differentiated CRC (including mucinous and signet ring features) was more prevalent in group 1 compared to group 2 (21.2% vs. 8%) (p = 0.001). Advanced CRC stages (III, IV) were significantly higher among the yCRC patients, with 63.3% of patients in group 1 diagnosed with advanced stages, compared to 59.6% (p = 0.001). Young patients with CRC were found to have more rectal involvement, with 35.6% of patients ≤ 45 years old compared to 23.9% in patients > 45 years old (p = 0.001).</p><p><strong>Conclusion: </strong>The reported incidence rate is approximately one-quarter of the newly diagnosed patients in Qatar. Patients with yCRC have a more aggressive and poorly differentiated histological type. The incidence of rectal cancer is higher in younger patients. Public awareness and screening policy have been implemented for better management.</p>","PeriodicalId":23856,"journal":{"name":"World Journal of Surgical Oncology","volume":"23 1","pages":"364"},"PeriodicalIF":2.5,"publicationDate":"2025-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12512660/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145259339","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
P2RX4 promotes hepatocellular carcinoma progression via calcium-mediated PI3K/AKT activation and immune remodeling. P2RX4通过钙介导的PI3K/AKT激活和免疫重塑促进肝细胞癌的进展。
IF 2.5 3区 医学
World Journal of Surgical Oncology Pub Date : 2025-10-09 DOI: 10.1186/s12957-025-04023-6
Jianrong Wang, Yanmei Gu, Ze Niu, Futian Tang, Yumin Li
{"title":"P2RX4 promotes hepatocellular carcinoma progression via calcium-mediated PI3K/AKT activation and immune remodeling.","authors":"Jianrong Wang, Yanmei Gu, Ze Niu, Futian Tang, Yumin Li","doi":"10.1186/s12957-025-04023-6","DOIUrl":"10.1186/s12957-025-04023-6","url":null,"abstract":"<p><strong>Background: </strong>Hepatocellular carcinoma (HCC) is frequently identified at advanced stages. This constrains therapeutic options and results in poor prognosis. P2RX4 is an ATP-gated ion channel that modulates calcium influx. It participates in cellular proliferation, inflammatory processes, and immunological reactions. Nonetheless, its role in HCC remains poorly comprehended. This study explored the expression, function, and immunological effects of P2RX4 in HCC.</p><p><strong>Methods: </strong>We examined P2RX4 expression using TCGA-LIHC and TIMER2.0 databases. Protein levels were validated using immunohistochemistry in 140 HCC tissues. A prognostic model was developed utilising P2RX4 expression. In vitro investigations were conducted subsequent to the silencing of P2RX4. The experiments encompassed cell proliferation, invasion, and colony formation. We further conducted transcriptome sequencing. Ion concentrations were quantified with ICP-OES. PI3K/AKT activation was evaluated using Western blotting.</p><p><strong>Results: </strong>P2RX4 exhibited elevated expression in HCC tissues. Its expression was associated with advanced tumor stage and poor prognosis. Silencing of P2RX4 decreased tumour cell proliferation and invasion. It also reduced intracellular calcium levels and inhibited AKT phosphorylation. Elevated P2RX4 levels correlated with an increased presence of M0 macrophages and Tregs, a reduced number of monocytes, and a poorer anticipated response to immunotherapy.</p><p><strong>Conclusions: </strong>P2RX4 may facilitate HCC progression by augmenting calcium influx, activating the PI3K/AKT pathway, and diminishing anti-tumor immunity. It may function as a biomarker and therapeutic target in HCC. Additional, in vivo investigations are required to validate these findings.</p>","PeriodicalId":23856,"journal":{"name":"World Journal of Surgical Oncology","volume":"23 1","pages":"363"},"PeriodicalIF":2.5,"publicationDate":"2025-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12512605/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145259299","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Rectal metastasis as the initial presentation of primary lung adenocarcinoma with an EGFR L858R mutation: a case report. 直肠转移是EGFR L858R突变的原发性肺腺癌的最初表现:1例报告
IF 2.5 3区 医学
World Journal of Surgical Oncology Pub Date : 2025-10-09 DOI: 10.1186/s12957-025-04016-5
Rui Nian, Mengzhu Wang, Juanyi Wang, Xiang Li, Jianjun Li, Ling Lin, Shushen Ji, Huihui Jiang, Wanjun Li
{"title":"Rectal metastasis as the initial presentation of primary lung adenocarcinoma with an EGFR L858R mutation: a case report.","authors":"Rui Nian, Mengzhu Wang, Juanyi Wang, Xiang Li, Jianjun Li, Ling Lin, Shushen Ji, Huihui Jiang, Wanjun Li","doi":"10.1186/s12957-025-04016-5","DOIUrl":"10.1186/s12957-025-04016-5","url":null,"abstract":"<p><strong>Background: </strong>Non-small cell lung cancer (NSCLC) accounts for approximately 80% of all Lung cancers, and 40% of patients with lung cancer present with distant metastases at diagnosis. Symptomatic rectal metastasis from primary lung adenocarcinoma before the onset of lung symptoms is exceedingly rare. This is the first report to describe an uncommon case of rectal metastasis from an EGFR L858R-mutant primary lung adenocarcinoma.</p><p><strong>Case presentation: </strong>A 79-year-old male presented to the hospital for worsening constipation. Colonoscopy revealed a rectal mass, but initial biopsies revealed only chronic rectal mucosal inflammation. The patient received symptomatic treatment to stimulate defecation, but his symptoms of constipation worsened. As symptoms progressed to dyspnoea, cough, expectoration, bilateral lower limb weakness, and poor appetite, imaging revealed a mixed ground-glass nodule with poorly defined margins in the apical segment of the right upper lobe. Imaging also revealed thickening of the rectal wall in the mid-to-lower segments with multiple small perirectal lymph nodes. Immunohistochemical analysis of both the rectal puncture biopsy specimen and the white nodules resected during the laparoscopic peritoneal biopsy consistently revealed CK7 (+), TTF-1 (+), Napsin A (+), CK20 (-), and CDX2 (-) staining, which confirmed rectal metastasis from primary lung adenocarcinoma. After the laparoscopic transverse colostomy was performed, the patient began treatment with aumolertinib mesilate tablets that target the EGFR L858R mutation and received palliative radiotherapy for the rectal metastatic lesion.</p><p><strong>Conclusions: </strong>Although rectal metastasis harbouring EGFR L858R mutations from primary lung adenocarcinoma is extremely rare, clinicians should have a low threshold for pulmonary low-dose spiral CT. In addition, histopathologic analysis by immunohistochemistry combined with molecular diagnostics is critical for a timely and accurate diagnosis and to distinguish rectal metastases from primary rectal malignancies.</p>","PeriodicalId":23856,"journal":{"name":"World Journal of Surgical Oncology","volume":"23 1","pages":"362"},"PeriodicalIF":2.5,"publicationDate":"2025-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12512643/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145259376","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Meta-analysis of the value of albumin-bilirubin grading on changes in liver function and its prognostic assessment in patients with hepatocellular carcinoma treated with transhepatic arterial chemoembolization. 经肝动脉化疗栓塞治疗的肝癌患者,白蛋白-胆红素分级对肝功能变化及预后评估价值的meta分析。
IF 2.5 3区 医学
World Journal of Surgical Oncology Pub Date : 2025-10-08 DOI: 10.1186/s12957-025-04033-4
Xinru Sun, Tao Wei, Tianhua Kang, Yin Zhang, Guangming Huang
{"title":"Meta-analysis of the value of albumin-bilirubin grading on changes in liver function and its prognostic assessment in patients with hepatocellular carcinoma treated with transhepatic arterial chemoembolization.","authors":"Xinru Sun, Tao Wei, Tianhua Kang, Yin Zhang, Guangming Huang","doi":"10.1186/s12957-025-04033-4","DOIUrl":"10.1186/s12957-025-04033-4","url":null,"abstract":"<p><strong>Objective: </strong>To analyze the application effect of albumin-bilirubin (ALBI) classification in assessing the changes in liver function and prognosis of hepatocellular carcinoma (HCC) patients after transhepatic arterial chemoembolization (TACE).</p><p><strong>Methods: </strong>Databases (such as Cochrane Library, PubMed, Embase, OVID, Web of Science) were used to collect and obtain all relevant studies on the changes in liver function and prognosis of HCC patients treated with TACE by ALBI classification. The literature was retrieved from the beginning of the database to September 2023. All analysis was performed by RevMan 5.4 software.</p><p><strong>Results: </strong>20 papers with 10,223 patients were included. Meta-analysis showed that the overall survival (OS) after TACE was shorter in HCC patients with higher ALBI grades than in those with lower ALBI grades (2nd vs. 1st : OR = 1.52, 95% CI: 1.42-1.64, P < 0.00001; 3rd vs. 1st : OR = 2.67, 95% CI: 1.87-3.80, P < 0.00001; 3rd vs. 2nd : OR = 1.94, 95% CI: 1.67-2.26, P < 0.00001). ALBI worsened more with 2 TACE accumulations than with 1 TACE (OR = 1.78, 95% CI: 1.11-2.85, P = 0.02), more with 3 TACE accumulations than with 1 TACE (OR = 3.22, 95% CI: 1.96-5.29, P < 0.00001), and more with 3 TACE accumulations than with 2 TACE (OR = 1.70, 95% CI: 1.07-2.71, P = 0.03). In addition, ALBI predicted the occurrence of ACLF (OR = 4.57, 95% CI: 2.76-7.57, P < 0.00001).</p><p><strong>Conclusion: </strong>ALBI classification is clinically important in assessing the prognosis of TACE and predicting the risk of ACLF, and repeated TACE treatment may lead to increased liver function impairment.</p>","PeriodicalId":23856,"journal":{"name":"World Journal of Surgical Oncology","volume":"23 1","pages":"361"},"PeriodicalIF":2.5,"publicationDate":"2025-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12506359/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145252983","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Combination of indocyanine green with medical adhesive for preoperative pulmonary nodule localization. 吲哚菁绿与医用胶联合应用于术前肺结节定位。
IF 2.5 3区 医学
World Journal of Surgical Oncology Pub Date : 2025-10-08 DOI: 10.1186/s12957-025-04021-8
Yulong Tan, Wenhao Wang, Xuan Wang, Baosen Wen, Haoxin Liu, Yifeng Qian, Quandong Zhu, Xiaofeng Chen, Huijun Zhang
{"title":"Combination of indocyanine green with medical adhesive for preoperative pulmonary nodule localization.","authors":"Yulong Tan, Wenhao Wang, Xuan Wang, Baosen Wen, Haoxin Liu, Yifeng Qian, Quandong Zhu, Xiaofeng Chen, Huijun Zhang","doi":"10.1186/s12957-025-04021-8","DOIUrl":"10.1186/s12957-025-04021-8","url":null,"abstract":"<p><strong>Background: </strong>Preoperative localization of pulmonary nodules is crucial for sublobar resection under thoracoscopy; however, controversy persists over the optimal localization method in terms of accuracy and safety. This study evaluates a novel technique integrating indocyanine green (ICG) with medical adhesive for pulmonary nodule localization.</p><p><strong>Materials and methods: </strong>In this single-center retrospective cohort, 168 consecutive patients (188 pulmonary nodules ≤ 2 cm) undergoing preoperative localization followed by uniportal thoracoscopic resection (July 2023 to June 2024) were divided into two groups: ICG combined with medical adhesive group (n = 86) versus medical adhesive group (n = 82). Localization outcomes, related complications, surgical and pathological outcomes were compared between the two groups.</p><p><strong>Results: </strong>There were no deaths or serious complications. All nodules were successfully resected thoracoscopically. The combined group demonstrated a shorter operative duration than the medical adhesive group (46.3 ± 6.7 min vs. 53.1 ± 5.9 min, P < 0.001). No statistically significant differences were identified in surgical type, length of stay, duration of drain tube retention, and total postoperative drainage volume between the two groups (P > 0.05).</p><p><strong>Conclusion: </strong>The combined use of ICG and medical adhesive for preoperative localization in uniportal thoracoscopic sublobar resection of small pulmonary nodules reduces operative time compared with medical adhesive positioning and demonstrates favorable safety profiles.</p>","PeriodicalId":23856,"journal":{"name":"World Journal of Surgical Oncology","volume":"23 1","pages":"360"},"PeriodicalIF":2.5,"publicationDate":"2025-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12506255/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145252966","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Construction and verification of reliability and validity of the communication skill assessment scale in cancer palliative care for healthcare staff. 癌症姑息治疗医护人员沟通技巧评估量表的编制及信效度验证。
IF 2.5 3区 医学
World Journal of Surgical Oncology Pub Date : 2025-10-02 DOI: 10.1186/s12957-025-04002-x
Lanying Qiu, Xi Yang, Yingjun Ye, Guanmian Liang, Jianwen Hou, Shuai Han, Xiaoxue Wen, Xiaoying Shen, Yitong Guo, Haoyang Li, Dan Fan, Shuping Xie, Xiaowei Fu
{"title":"Construction and verification of reliability and validity of the communication skill assessment scale in cancer palliative care for healthcare staff.","authors":"Lanying Qiu, Xi Yang, Yingjun Ye, Guanmian Liang, Jianwen Hou, Shuai Han, Xiaoxue Wen, Xiaoying Shen, Yitong Guo, Haoyang Li, Dan Fan, Shuping Xie, Xiaowei Fu","doi":"10.1186/s12957-025-04002-x","DOIUrl":"10.1186/s12957-025-04002-x","url":null,"abstract":"<p><strong>Objective: </strong>We aimed to construct and test the reliability and validity of the communication skill assessment scale in cancer palliative care for healthcare staff.</p><p><strong>Methods: </strong>The concept of communication skills was defined by the literature review. The palliative care communication skill assessment scale was developed through literature analysis, an open questionnaire survey, and expert correspondence. A total of 485 healthcare staff, including doctors and nurses, who worked in the medical oncology department of a Grade-A oncology hospital in Zhejiang Province were selected to screen the items of the scale and test their reliability and validity.</p><p><strong>Results: </strong>There were 39 items in the final version of the palliative care communication skill assessment scale for healthcare staff. Through exploratory factor analysis, six common factors were extracted, and the cumulative variance contribution rate was 80.47%. Item content validity index (CVI) ranged from 0.78 to 1.00, and the overall CVI of the scale was 0.91. The internal correlation test showed that the correlation coefficient of each dimension of the scale with a total score was 0.59-0.76 (p < 0.05), and the inter-dimension correlation coefficient was 0.46-0.51 (p < 0.05). The Kronbach coefficient of the aggregate table was 0.928. The retest reliability was 0.89. The broken half reliability was 0.84.</p><p><strong>Conclusion: </strong>The palliative care communication skill assessment scale we constructed has good reliability and validity, and it can be used to evaluate the communication skills of healthcare staff during palliative care.</p>","PeriodicalId":23856,"journal":{"name":"World Journal of Surgical Oncology","volume":"23 1","pages":"358"},"PeriodicalIF":2.5,"publicationDate":"2025-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12492915/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145213673","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Maximal feasible resection versus hybrid therapy in spinal metastases: an updated narrative review. 最大可行切除与混合治疗在脊柱转移:一个最新的叙事回顾。
IF 2.5 3区 医学
World Journal of Surgical Oncology Pub Date : 2025-10-02 DOI: 10.1186/s12957-025-04009-4
Zhilong Zestel Shen, Pengru Wang, Yuechao Zhao, Yingye Xin, Hao Zhang, Xin Zhang, Bo Li, Wei Xu, Jianru Xiao
{"title":"Maximal feasible resection versus hybrid therapy in spinal metastases: an updated narrative review.","authors":"Zhilong Zestel Shen, Pengru Wang, Yuechao Zhao, Yingye Xin, Hao Zhang, Xin Zhang, Bo Li, Wei Xu, Jianru Xiao","doi":"10.1186/s12957-025-04009-4","DOIUrl":"10.1186/s12957-025-04009-4","url":null,"abstract":"<p><p>The neurologic, oncologic, mechanical and systemic (NOMS) decision framework provides a widely recognized decision-making strategy for spinal metastases. The combination of stereotactic body radiation therapy (SBRT) and separation surgery-referred to as hybrid therapy (HT)-has emerged as a prevailing paradigm. However, with the advent of targeted therapies and immunotherapies, advances in surgical technologies, and limited global accessibility to stereotactic radiosurgery, controversies have arisen regarding the optimal roles of maximal feasible resection (MFR) and HT. In light of these evolving dynamics, a critical reassessment of current treatment strategies is warranted. This narrative review provides a comprehensive overview of the developmental trajectories of MFR and HT, elucidating their respective advantages, current clinical evidence, ongoing debates, and practical challenges related to patient selection and therapeutic prioritization. Future research is anticipated to focus on three major areas: (1) conducting high-quality clinical trials within different therapeutic modalities; (2) developing therapeutic strategies that are compatible with both MFR and HT; and (3) further exploring novel technologies and their applications. These initiatives are expected to guide future research, optimize clinical decision-making and ultimately improve patient outcomes. Given the narrative nature of this review, systematic bias may exist despite comprehensive coverage of the available evidence.</p>","PeriodicalId":23856,"journal":{"name":"World Journal of Surgical Oncology","volume":"23 1","pages":"357"},"PeriodicalIF":2.5,"publicationDate":"2025-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12492667/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145213742","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Association of progesterone receptor status with breast cancer prognosis: a meta-analysis. 孕激素受体状态与乳腺癌预后的关系:一项荟萃分析。
IF 2.5 3区 医学
World Journal of Surgical Oncology Pub Date : 2025-10-02 DOI: 10.1186/s12957-025-04001-y
Yiming Hou, Jianrong Li, Qiong Zhang, Yingyi Fan
{"title":"Association of progesterone receptor status with breast cancer prognosis: a meta-analysis.","authors":"Yiming Hou, Jianrong Li, Qiong Zhang, Yingyi Fan","doi":"10.1186/s12957-025-04001-y","DOIUrl":"10.1186/s12957-025-04001-y","url":null,"abstract":"<p><strong>Background: </strong>Breast cancer (BC) prognosis is influenced by hormones, of which progesterone receptor (PR) status is controversial for BC prognosis, possibly related to clinical characteristics.</p><p><strong>Objective: </strong>This study was to determine the impact of PR status on BC prognosis and explore the differences across patient subgroups.</p><p><strong>Methods: </strong>PubMed, Cochrane Library, Embase, and Web of Science were searched for relevant studies until July 2024. NOS (Newcastle-Ottawa Scale) was leveraged for quality appraisal. Meta-analysis was performed using STATA15.1.</p><p><strong>Results: </strong>Thirty-five studies were included, involving 89,164 patients. PR-negative status was associated with worse overall survival compared to PR-positive status (HR 1.70, 95%CI 1.42 to 2.04; p < 0.001). Similar results were unveiled for disease-free survival (HR 1.62, 95%CI 1.23 to 2.14, p < 0.001), breast-cancer-specific survival (HR 2.45, 95% CI 1.85 to 3.23, p < 0.001), and recurrence-free survival (HR 1.47, 95% CI 1.21 to 1.79, p < 0.001). Subgroup analyses unveiled that conclusions were influenced by region, estrogen receptor (ER) status, human epidermal growth factor receptor 2 (HER2) status, menopausal status, and metastatic status.</p><p><strong>Conclusion: </strong>PR loss is associated with worse outcomes in BC, which is influenced by clinical characteristics. Especially in patients with ER + HER2- tumors, PR status may serve as an additional predictive marker.</p>","PeriodicalId":23856,"journal":{"name":"World Journal of Surgical Oncology","volume":"23 1","pages":"356"},"PeriodicalIF":2.5,"publicationDate":"2025-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12490167/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145207899","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Comparison of the anti-reflux ileum valve-pouch orthotopic neobladder and the Studer technique after radical cystecomy: surgical and renal functional outcomes. 根治性膀胱切除术后抗反流回肠瓣袋原位新膀胱与Studer技术的比较:手术和肾功能结果。
IF 2.5 3区 医学
World Journal of Surgical Oncology Pub Date : 2025-10-02 DOI: 10.1186/s12957-025-03699-0
Zaisheng Zhu, Yiyi Zhu, Wenmin Ying, Han Wu, Penfei Zhou, Quanqi Liu, Jianyong Tong, Yueping Wang
{"title":"Comparison of the anti-reflux ileum valve-pouch orthotopic neobladder and the Studer technique after radical cystecomy: surgical and renal functional outcomes.","authors":"Zaisheng Zhu, Yiyi Zhu, Wenmin Ying, Han Wu, Penfei Zhou, Quanqi Liu, Jianyong Tong, Yueping Wang","doi":"10.1186/s12957-025-03699-0","DOIUrl":"10.1186/s12957-025-03699-0","url":null,"abstract":"<p><strong>Background: </strong>This study describes the construction of an anti-reflux neobladder using an ileum valve-pouch (IVP) and compares its efficacy with that of the modified Studer-pouch (MSP).</p><p><strong>Methods: </strong>This study included a total of 127 patients who underwent radical cystectomy + neobladder construction (IVP: n = 66; MSP = 61) between January 2015 and June 2023 at two major medical centers in our city. Potential bias was reduced by 1:1 propensity score matching (PSM) to compare oncology, complications, and renal function protection between the two groups. The estimated glomerular filtration rate (eGFR) was calculated using the CKD-EPI (Chronic Kidney Disease Epidemiology Collaboration) equation. Survival was assessed using Kaplan-Meier analysis.</p><p><strong>Results: </strong>The median follow-up time was 44.5 and 35.5 months in the IVP and MSP groups, respectively. After propensity scoring, 84 patients (42 in each group) were included in the analysis.There was no significant statistical difference in the operation time(p = 0.128) and the time of urinary diversion (p = 0.354) between the two groups.Kaplan-Meier curves showed no significant differences in cancer-specific survival (CSS) (p = 0.181) and overall survival (OS) (p = 0.611) between the two groups. In addition, the total complications and renal function were not statistically different between the two groups (p > 0.05). The incidence of patients who needed to be re-hospitalized due to urinary tract infection was lower in the VIP group than in the MSP group (p = 0.039). At 12 months postoperatively, lower rates of decreased eGFR and renal function damage were observed in the IVP group compared to the MSP group (p = 0.031 and < 0.001), which were significantly related to the type of neobladder (p = 0.004) and preoperative eGFR values (p < 0.001).</p><p><strong>Conclusion: </strong>The preliminary results of VIP technique are safe and effective. It does not increase the time of anti-reflux construction. The incidence of complications similar in the two groups. However, the protection of renal function at 12 months after surgery seemed to be superior to MSP.The independent factors affecting renal function damage are neobladder type and preoperative eGFR.</p>","PeriodicalId":23856,"journal":{"name":"World Journal of Surgical Oncology","volume":"23 1","pages":"359"},"PeriodicalIF":2.5,"publicationDate":"2025-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12492917/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145213768","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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