Young-onset versus late-onset colorectal cancer: clinicopathological features and survival outcome: a decade-long analysis from a middle Eastern tertiary center.

IF 2.5 3区医学 Q3 ONCOLOGY

World Journal of Surgical Oncology Pub Date : 2025-10-09 DOI:10.1186/s12957-025-04010-x

Ammar Aleter, Ali Toffaha, Ejaz Ahmed Latif, Mahwish Khawar, Ibrahim Amer, Samer A Hasan, Mahmood Al-Dhaheri, Ayman Ahmed, Ayman El-Menyar, Mohamed Abu Nada, Amjad Parvaiz

{"title":"Young-onset versus late-onset colorectal cancer: clinicopathological features and survival outcome: a decade-long analysis from a middle Eastern tertiary center.","authors":"Ammar Aleter, Ali Toffaha, Ejaz Ahmed Latif, Mahwish Khawar, Ibrahim Amer, Samer A Hasan, Mahmood Al-Dhaheri, Ayman Ahmed, Ayman El-Menyar, Mohamed Abu Nada, Amjad Parvaiz","doi":"10.1186/s12957-025-04010-x","DOIUrl":null,"url":null,"abstract":"Background: Colorectal cancer (CRC) incidence is reported to be declining overall in many countries but growing among young adults. The updated American Cancer Society (ACS) guidelines recommend screening starting at age 45 years. We sought to evaluate population-level trends in young colorectal cancer (yCRC) epidemiology in Qatar, a country in the Middle East.Methods: Between January 2010 and December 2020, we included 1529 patients from the National Registry Database with a 5-year follow-up. The patients were divided into two groups. Group 1 (n = 380, ≤ 45 years) and group 2 (n = 1149, > 45). The epidemiological and clinicopathological features were analyzed and compared in the two groups.Results: The annual incidence rate of CRC in Qatar from 2010 to 2020 ranged from 5.3 to 7.2 per 100,000 population, with an average of 5.79 per 100,000 population over this period. The overall prevalence among males was 65.6%. The incidence of CRC in young patients was approximately 1 in every four patients (24.8%). Males comprised almost two-thirds of the entire CRC cohort, yCRC, as well as the old-onset CRC cohort. The poorly differentiated CRC (including mucinous and signet ring features) was more prevalent in group 1 compared to group 2 (21.2% vs. 8%) (p = 0.001). Advanced CRC stages (III, IV) were significantly higher among the yCRC patients, with 63.3% of patients in group 1 diagnosed with advanced stages, compared to 59.6% (p = 0.001). Young patients with CRC were found to have more rectal involvement, with 35.6% of patients ≤ 45 years old compared to 23.9% in patients > 45 years old (p = 0.001).Conclusion: The reported incidence rate is approximately one-quarter of the newly diagnosed patients in Qatar. Patients with yCRC have a more aggressive and poorly differentiated histological type. The incidence of rectal cancer is higher in younger patients. Public awareness and screening policy have been implemented for better management.","PeriodicalId":23856,"journal":{"name":"World Journal of Surgical Oncology","volume":"23 1","pages":"364"},"PeriodicalIF":2.5000,"publicationDate":"2025-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12512660/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"World Journal of Surgical Oncology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1186/s12957-025-04010-x","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"ONCOLOGY","Score":null,"Total":0}

引用次数: 0

Abstract

Background: Colorectal cancer (CRC) incidence is reported to be declining overall in many countries but growing among young adults. The updated American Cancer Society (ACS) guidelines recommend screening starting at age 45 years. We sought to evaluate population-level trends in young colorectal cancer (yCRC) epidemiology in Qatar, a country in the Middle East.

Methods: Between January 2010 and December 2020, we included 1529 patients from the National Registry Database with a 5-year follow-up. The patients were divided into two groups. Group 1 (n = 380, ≤ 45 years) and group 2 (n = 1149, > 45). The epidemiological and clinicopathological features were analyzed and compared in the two groups.

Results: The annual incidence rate of CRC in Qatar from 2010 to 2020 ranged from 5.3 to 7.2 per 100,000 population, with an average of 5.79 per 100,000 population over this period. The overall prevalence among males was 65.6%. The incidence of CRC in young patients was approximately 1 in every four patients (24.8%). Males comprised almost two-thirds of the entire CRC cohort, yCRC, as well as the old-onset CRC cohort. The poorly differentiated CRC (including mucinous and signet ring features) was more prevalent in group 1 compared to group 2 (21.2% vs. 8%) (p = 0.001). Advanced CRC stages (III, IV) were significantly higher among the yCRC patients, with 63.3% of patients in group 1 diagnosed with advanced stages, compared to 59.6% (p = 0.001). Young patients with CRC were found to have more rectal involvement, with 35.6% of patients ≤ 45 years old compared to 23.9% in patients > 45 years old (p = 0.001).

Conclusion: The reported incidence rate is approximately one-quarter of the newly diagnosed patients in Qatar. Patients with yCRC have a more aggressive and poorly differentiated histological type. The incidence of rectal cancer is higher in younger patients. Public awareness and screening policy have been implemented for better management.

查看原文本刊更多论文

早发性与晚发性结直肠癌：临床病理特征和生存结果：来自中东三级中心长达十年的分析

背景：据报道，结直肠癌（CRC）发病率在许多国家总体上呈下降趋势，但在年轻人中呈上升趋势。最新的美国癌症协会（ACS）指南建议从45岁开始筛查。我们试图评估中东国家卡塔尔青年结直肠癌（yCRC）流行病学的人口水平趋势。方法：2010年1月至2020年12月，我们从国家注册数据库中纳入1529例患者，随访5年。患者被分为两组。组1 （n = 380，≤45岁）和组2 （n = 1149，≤45岁）。分析比较两组患者的流行病学和临床病理特征。结果：卡塔尔2010 - 2020年CRC年发病率为5.3 - 7.2 / 10万人，同期平均发病率为5.79 / 10万人。男性总患病率为65.6%。年轻患者的CRC发病率约为1 / 4（24.8%）。男性几乎占整个CRC队列的三分之二，包括yCRC和老发CRC队列。低分化CRC（包括粘液和印戒特征）在1组中比2组更普遍（21.2%比8%）（p = 0.001）。晚期CRC （III、IV期）在yCRC患者中明显较高，1组中63.3%的患者被诊断为晚期，而59.6%的患者被诊断为晚期（p = 0.001）。年轻的结直肠癌患者有更多的直肠受累，年龄≤45岁的患者占35.6%，而年龄≤45岁的患者占23.9% （p = 0.001）。结论：报告的发病率约为卡塔尔新诊断患者的四分之一。yCRC患者具有更强侵袭性和低分化的组织学类型。直肠癌的发病率在年轻患者中较高。为了更好地管理，已经实施了公众意识和筛查政策。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

World Journal of Surgical Oncology ONCOLOGY-SURGERY

CiteScore

4.70

自引率

15.60%

发文量

362

审稿时长

3 months

期刊介绍： World Journal of Surgical Oncology publishes articles related to surgical oncology and its allied subjects, such as epidemiology, cancer research, biomarkers, prevention, pathology, radiology, cancer treatment, clinical trials, multimodality treatment and molecular biology. Emphasis is placed on original research articles. The journal also publishes significant clinical case reports, as well as balanced and timely reviews on selected topics. Oncology is a multidisciplinary super-speciality of which surgical oncology forms an integral component, especially with solid tumors. Surgical oncologists around the world are involved in research extending from detecting the mechanisms underlying the causation of cancer, to its treatment and prevention. The role of a surgical oncologist extends across the whole continuum of care. With continued developments in diagnosis and treatment, the role of a surgical oncologist is ever-changing. Hence, World Journal of Surgical Oncology aims to keep readers abreast with latest developments that will ultimately influence the work of surgical oncologists.