Xinru Sun, Tao Wei, Tianhua Kang, Yin Zhang, Guangming Huang
{"title":"经肝动脉化疗栓塞治疗的肝癌患者，白蛋白-胆红素分级对肝功能变化及预后评估价值的meta分析。","authors":"Xinru Sun, Tao Wei, Tianhua Kang, Yin Zhang, Guangming Huang","doi":"10.1186/s12957-025-04033-4","DOIUrl":null,"url":null,"abstract":"<p><strong>Objective: </strong>To analyze the application effect of albumin-bilirubin (ALBI) classification in assessing the changes in liver function and prognosis of hepatocellular carcinoma (HCC) patients after transhepatic arterial chemoembolization (TACE).</p><p><strong>Methods: </strong>Databases (such as Cochrane Library, PubMed, Embase, OVID, Web of Science) were used to collect and obtain all relevant studies on the changes in liver function and prognosis of HCC patients treated with TACE by ALBI classification. The literature was retrieved from the beginning of the database to September 2023. All analysis was performed by RevMan 5.4 software.</p><p><strong>Results: </strong>20 papers with 10,223 patients were included. Meta-analysis showed that the overall survival (OS) after TACE was shorter in HCC patients with higher ALBI grades than in those with lower ALBI grades (2nd vs. 1st : OR = 1.52, 95% CI: 1.42-1.64, P < 0.00001; 3rd vs. 1st : OR = 2.67, 95% CI: 1.87-3.80, P < 0.00001; 3rd vs. 2nd : OR = 1.94, 95% CI: 1.67-2.26, P < 0.00001). ALBI worsened more with 2 TACE accumulations than with 1 TACE (OR = 1.78, 95% CI: 1.11-2.85, P = 0.02), more with 3 TACE accumulations than with 1 TACE (OR = 3.22, 95% CI: 1.96-5.29, P < 0.00001), and more with 3 TACE accumulations than with 2 TACE (OR = 1.70, 95% CI: 1.07-2.71, P = 0.03). In addition, ALBI predicted the occurrence of ACLF (OR = 4.57, 95% CI: 2.76-7.57, P < 0.00001).</p><p><strong>Conclusion: </strong>ALBI classification is clinically important in assessing the prognosis of TACE and predicting the risk of ACLF, and repeated TACE treatment may lead to increased liver function impairment.</p>","PeriodicalId":23856,"journal":{"name":"World Journal of Surgical Oncology","volume":"23 1","pages":"361"},"PeriodicalIF":2.5000,"publicationDate":"2025-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12506359/pdf/","citationCount":"0","resultStr":"{\"title\":\"Meta-analysis of the value of albumin-bilirubin grading on changes in liver function and its prognostic assessment in patients with hepatocellular carcinoma treated with transhepatic arterial chemoembolization.\",\"authors\":\"Xinru Sun, Tao Wei, Tianhua Kang, Yin Zhang, Guangming Huang\",\"doi\":\"10.1186/s12957-025-04033-4\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Objective: </strong>To analyze the application effect of albumin-bilirubin (ALBI) classification in assessing the changes in liver function and prognosis of hepatocellular carcinoma (HCC) patients after transhepatic arterial chemoembolization (TACE).</p><p><strong>Methods: </strong>Databases (such as Cochrane Library, PubMed, Embase, OVID, Web of Science) were used to collect and obtain all relevant studies on the changes in liver function and prognosis of HCC patients treated with TACE by ALBI classification. The literature was retrieved from the beginning of the database to September 2023. All analysis was performed by RevMan 5.4 software.</p><p><strong>Results: </strong>20 papers with 10,223 patients were included. Meta-analysis showed that the overall survival (OS) after TACE was shorter in HCC patients with higher ALBI grades than in those with lower ALBI grades (2nd vs. 1st : OR = 1.52, 95% CI: 1.42-1.64, P < 0.00001; 3rd vs. 1st : OR = 2.67, 95% CI: 1.87-3.80, P < 0.00001; 3rd vs. 2nd : OR = 1.94, 95% CI: 1.67-2.26, P < 0.00001). ALBI worsened more with 2 TACE accumulations than with 1 TACE (OR = 1.78, 95% CI: 1.11-2.85, P = 0.02), more with 3 TACE accumulations than with 1 TACE (OR = 3.22, 95% CI: 1.96-5.29, P < 0.00001), and more with 3 TACE accumulations than with 2 TACE (OR = 1.70, 95% CI: 1.07-2.71, P = 0.03). In addition, ALBI predicted the occurrence of ACLF (OR = 4.57, 95% CI: 2.76-7.57, P < 0.00001).</p><p><strong>Conclusion: </strong>ALBI classification is clinically important in assessing the prognosis of TACE and predicting the risk of ACLF, and repeated TACE treatment may lead to increased liver function impairment.</p>\",\"PeriodicalId\":23856,\"journal\":{\"name\":\"World Journal of Surgical Oncology\",\"volume\":\"23 1\",\"pages\":\"361\"},\"PeriodicalIF\":2.5000,\"publicationDate\":\"2025-10-08\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12506359/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"World Journal of Surgical Oncology\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1186/s12957-025-04033-4\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"ONCOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"World Journal of Surgical Oncology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1186/s12957-025-04033-4","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"ONCOLOGY","Score":null,"Total":0}
Meta-analysis of the value of albumin-bilirubin grading on changes in liver function and its prognostic assessment in patients with hepatocellular carcinoma treated with transhepatic arterial chemoembolization.
Objective: To analyze the application effect of albumin-bilirubin (ALBI) classification in assessing the changes in liver function and prognosis of hepatocellular carcinoma (HCC) patients after transhepatic arterial chemoembolization (TACE).
Methods: Databases (such as Cochrane Library, PubMed, Embase, OVID, Web of Science) were used to collect and obtain all relevant studies on the changes in liver function and prognosis of HCC patients treated with TACE by ALBI classification. The literature was retrieved from the beginning of the database to September 2023. All analysis was performed by RevMan 5.4 software.
Results: 20 papers with 10,223 patients were included. Meta-analysis showed that the overall survival (OS) after TACE was shorter in HCC patients with higher ALBI grades than in those with lower ALBI grades (2nd vs. 1st : OR = 1.52, 95% CI: 1.42-1.64, P < 0.00001; 3rd vs. 1st : OR = 2.67, 95% CI: 1.87-3.80, P < 0.00001; 3rd vs. 2nd : OR = 1.94, 95% CI: 1.67-2.26, P < 0.00001). ALBI worsened more with 2 TACE accumulations than with 1 TACE (OR = 1.78, 95% CI: 1.11-2.85, P = 0.02), more with 3 TACE accumulations than with 1 TACE (OR = 3.22, 95% CI: 1.96-5.29, P < 0.00001), and more with 3 TACE accumulations than with 2 TACE (OR = 1.70, 95% CI: 1.07-2.71, P = 0.03). In addition, ALBI predicted the occurrence of ACLF (OR = 4.57, 95% CI: 2.76-7.57, P < 0.00001).
Conclusion: ALBI classification is clinically important in assessing the prognosis of TACE and predicting the risk of ACLF, and repeated TACE treatment may lead to increased liver function impairment.
期刊介绍：
World Journal of Surgical Oncology publishes articles related to surgical oncology and its allied subjects, such as epidemiology, cancer research, biomarkers, prevention, pathology, radiology, cancer treatment, clinical trials, multimodality treatment and molecular biology. Emphasis is placed on original research articles. The journal also publishes significant clinical case reports, as well as balanced and timely reviews on selected topics.
Oncology is a multidisciplinary super-speciality of which surgical oncology forms an integral component, especially with solid tumors. Surgical oncologists around the world are involved in research extending from detecting the mechanisms underlying the causation of cancer, to its treatment and prevention. The role of a surgical oncologist extends across the whole continuum of care. With continued developments in diagnosis and treatment, the role of a surgical oncologist is ever-changing. Hence, World Journal of Surgical Oncology aims to keep readers abreast with latest developments that will ultimately influence the work of surgical oncologists.
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