World Journal of Surgical Oncology最新文献

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Predictive value of machine learning for PD-L1 expression in NSCLC: a systematic review and meta-analysis. 机器学习对非小细胞肺癌PD-L1表达的预测价值:一项系统综述和荟萃分析。
IF 2.5 3区 医学
World Journal of Surgical Oncology Pub Date : 2025-05-22 DOI: 10.1186/s12957-025-03847-6
Ting Zheng, Xingxing Li, Li Zhou, Jianjiang Jin
{"title":"Predictive value of machine learning for PD-L1 expression in NSCLC: a systematic review and meta-analysis.","authors":"Ting Zheng, Xingxing Li, Li Zhou, Jianjiang Jin","doi":"10.1186/s12957-025-03847-6","DOIUrl":"10.1186/s12957-025-03847-6","url":null,"abstract":"<p><strong>Background: </strong>As machine learning (ML) continuously develops in cancer diagnosis and treatment, some researchers have attempted to predict the expression of programmed death ligand-1 (PD-L1) in non-small cell lung cancer (NSCLC) by ML. However, there is a lack of systematic evidence on the effectiveness of ML.</p><p><strong>Methods: </strong>We conducted a thorough search across Embase, PubMed, the Cochrane Library, and Web of Science from inception to December 14th, 2023.A systematic review and meta-analysis was conducted to assess the value of ML for predicting PD-L1 expression in NSCLC.</p><p><strong>Results: </strong>Totally 30 studies with 12,898 NSCLC patients were included. The thresholds of PD-L1 expression level were < 1%, 1-49%, and ≥ 50%. In the validation set, in the binary classification for PD-L1 ≥ 1%, the pooled C-index was 0.646 (95%CI: 0.587-0.705), 0.799 (95%CI: 0.782-0.817), 0.806 (95%CI: 0.753-0.858), and 0.800 (95%CI: 0.717-0.883), respectively, for the clinical feature-, radiomics-, radiomics + clinical feature-, and pathomics-based ML models; in the binary classification for PD-L1 ≥ 50%, the pooled C-index was 0.649 (95%CI: 0.553-0.744), 0.771 (95%CI: 0.728-0.814), and 0.826 (95%CI: 0.783-0.869), respectively, for the clinical feature-, radiomics-, and radiomics + clinical feature-based ML models.</p><p><strong>Conclusions: </strong>At present, radiomics- or pathomics-based ML methods are applied for the prediction of PD-L1 expression in NSCLC, which both achieve satisfactory accuracy. In particular, the radiomics-based ML method seems to have wider clinical applicability as a non-invasive diagnostic tool. Both radiomics and pathomics serve as processing methods for medical images. In the future, we expect to develop medical image-based DL methods for intelligently predicting PD-L1 expression.</p>","PeriodicalId":23856,"journal":{"name":"World Journal of Surgical Oncology","volume":"23 1","pages":"199"},"PeriodicalIF":2.5,"publicationDate":"2025-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12101016/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144128914","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Optimized prosthetic design, surgical technique, and cosmetic outcome in shoulder reconstruction with double-constrained implant following extra-articular shoulder resection: a proof-of-concept. 优化假体设计、手术技术和关节外肩关节切除术后双约束假体肩关节重建的美容效果:概念验证。
IF 2.5 3区 医学
World Journal of Surgical Oncology Pub Date : 2025-05-16 DOI: 10.1186/s12957-025-03844-9
Jan Lesensky, Michal Benes, Martin Havranek, Ana C Belzarena
{"title":"Optimized prosthetic design, surgical technique, and cosmetic outcome in shoulder reconstruction with double-constrained implant following extra-articular shoulder resection: a proof-of-concept.","authors":"Jan Lesensky, Michal Benes, Martin Havranek, Ana C Belzarena","doi":"10.1186/s12957-025-03844-9","DOIUrl":"10.1186/s12957-025-03844-9","url":null,"abstract":"<p><p>Reconstruction of the anatomic defect following extra-articular shoulder resection is a challenging problem, particularly in cases when function of the deltoid muscle and rotator cuff are compromised. Standard reconstruction techniques often result in either instability or rigidity. Constrained implants have been used to overcome these problems; however, they have been associated with a high rate of aseptic loosening. Recently, a novel double-constrained implant has been introduced, yielding promising functional results. Nonetheless, this implant exhibited a cosmetic defect related to protrusion of the humeral component that becomes apparent with time as result of surrounding muscle atrophy. An updated improved design of the implant has been developed to counteract this.We report the case of a 15-year-old patient who underwent an extra-articular (Malawer type V) shoulder resection due to osteosarcoma and received an innovated custom-made double-constrained implant. Moreover, we describe a new modification of the Malawer utilitarian approach to the shoulder girdle that enhances tumor visibility and allows safer dissection. The patient recovered well with satisfactory outcomes at 18 months follow-up, highlighting the potential benefits of this implant design and surgical approach.</p>","PeriodicalId":23856,"journal":{"name":"World Journal of Surgical Oncology","volume":"23 1","pages":"194"},"PeriodicalIF":2.5,"publicationDate":"2025-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12083034/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144086853","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Prognostic and clinicopathological value of fibrinogen-to-albumin ratio in non-small cell lung cancer: a meta-analysis. 非小细胞肺癌中纤维蛋白原与白蛋白比值的预后和临床病理价值:一项荟萃分析。
IF 2.5 3区 医学
World Journal of Surgical Oncology Pub Date : 2025-05-16 DOI: 10.1186/s12957-025-03832-z
Ling Tong, Hui Hu, Jiashan Li, Lihai Pan
{"title":"Prognostic and clinicopathological value of fibrinogen-to-albumin ratio in non-small cell lung cancer: a meta-analysis.","authors":"Ling Tong, Hui Hu, Jiashan Li, Lihai Pan","doi":"10.1186/s12957-025-03832-z","DOIUrl":"10.1186/s12957-025-03832-z","url":null,"abstract":"<p><strong>Background: </strong>The fibrinogen-to-albumin ratio (FAR) has been explored for its role in predicting non-small cell lung cancer (NSCLC) prognosis, but findings remain inconsistent. This study aimed to determine the exact impact of FAR on predicting NSCLC prognosis through a meta-analysis.</p><p><strong>Methods: </strong>This study conducted a comprehensive search of PubMed, Web of Science, Embase, Cochrane Library, and CNKI up to April 2, 2025, and determined pooled hazard ratios (HRs) and 95% confidence intervals (CIs) to evaluate the prognostic value of FAR in NSCLC.</p><p><strong>Results: </strong>This meta-analysis included seven studies with a total of 2,655 cases. The pooled analysis revealed that an elevated FAR significantly predicted poor overall survival (OS) (HR = 1.82, 95% CI = 1.56-2.14, p < 0.001) and poor progression-free survival (PFS) (HR = 1.50, 95% CI = 1.29-1.74, p < 0.001) in patients with NSCLC, which was strongly associated with male sex (OR = 1.53, 95% CI = 1.12-2.08, p = 0.008) and tumor size ≥ 5 cm (OR = 1.52, 95% CI = 1.08-2.14, p = 0.017). However, FAR showed no significant correlation with smoking history (OR = 1.44, 95% CI = 0.80-2.59, p = 0.218) or Eastern Cooperative Oncology Group performance status (OR = 1.60, 95% CI = 0.74-3.45, p = 0.230).</p><p><strong>Conclusion: </strong>This meta-analysis suggests that elevated FAR is a strong predictor of OS and PFS in patients with Chinese NSCLC and correlates with larger tumor size.</p>","PeriodicalId":23856,"journal":{"name":"World Journal of Surgical Oncology","volume":"23 1","pages":"196"},"PeriodicalIF":2.5,"publicationDate":"2025-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12082923/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144086854","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The association of immune-inflammation indices at multiple time points with treatment response and survival in advanced non-small cell lung cancer patients receiving immune checkpoint inhibitors. 在接受免疫检查点抑制剂的晚期非小细胞肺癌患者中,多个时间点的免疫炎症指数与治疗反应和生存的关系
IF 2.5 3区 医学
World Journal of Surgical Oncology Pub Date : 2025-05-16 DOI: 10.1186/s12957-025-03833-y
Yaqing Li, Jianping Xu, Lijuan Zhang, Zhigang Cai
{"title":"The association of immune-inflammation indices at multiple time points with treatment response and survival in advanced non-small cell lung cancer patients receiving immune checkpoint inhibitors.","authors":"Yaqing Li, Jianping Xu, Lijuan Zhang, Zhigang Cai","doi":"10.1186/s12957-025-03833-y","DOIUrl":"10.1186/s12957-025-03833-y","url":null,"abstract":"<p><strong>Background: </strong>Immune and inflammation participate in the progression of non-small cell lung cancer (NSCLC) and some immune-inflammation indexes may serve as prognostic biomarkers in NSCLC patients. This study aimed to investigate the association between immune-inflammation indices at multiple time points and prognosis in advanced NSCLC patients treated with immune checkpoint inhibitors (ICIs).</p><p><strong>Methods: </strong>This retrospective study included 102 advanced NSCLC patients treated with ICIs and collected their blood indices within 7 days before treatment (T1), before the 3rd treatment cycle (T2), and before the 5th treatment cycle (T3) to calculate neutrophil-to-lymphocyte ratio (NLR), derived neutrophil-to-lymphocyte ratio (dNLR), pan-immune-inflammatory value (PIV), systemic immune-inflammation index (SII), prognostic nutritional index (PNI), and lung immune prognostic index (LIPI).</p><p><strong>Results: </strong>dNLR (P = 0.006), SII (P = 0.005), PIV (P = 0.010), and LIPI (P = 0.001) reduced, while PNI increased (P = 0.009) from T1 to T3; NLR was not different among T1, T2, and T3 (P = 0.282). A lower NLR (P = 0.011) and higher PNI (P = 0.026) at T3, and lower LIPI at T2 (P = 0.023) were related to better disease control rate, but these immune-inflammation indices were not linked with objective response rate at any timepoint. Multivariate Cox regression analysis showed that high NLR at T1 was independently related to worse PFS (hazard ratio: 4.187, P = 0.008), while high PNI at T3 was independently associated with better PFS (hazard ratio: 0.454, P = 0.021).</p><p><strong>Conclusion: </strong>NLR before and after treatment, as well as PNI and LIPI after treatment may serve as potential biomarkers for treatment response or survival in advanced NSCLC patients receiving ICIs.</p>","PeriodicalId":23856,"journal":{"name":"World Journal of Surgical Oncology","volume":"23 1","pages":"195"},"PeriodicalIF":2.5,"publicationDate":"2025-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12082983/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144086856","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
SDC1 is a critical transmembrane proteoglycan in breast cancer. SDC1是乳腺癌中一种重要的跨膜蛋白多糖。
IF 2.5 3区 医学
World Journal of Surgical Oncology Pub Date : 2025-05-16 DOI: 10.1186/s12957-025-03840-z
Yingying Mei, Lantao Zhao, Na Zhou
{"title":"SDC1 is a critical transmembrane proteoglycan in breast cancer.","authors":"Yingying Mei, Lantao Zhao, Na Zhou","doi":"10.1186/s12957-025-03840-z","DOIUrl":"10.1186/s12957-025-03840-z","url":null,"abstract":"<p><p>There has been an increasing incidence of breast cancer around the world in recent years. As a burgeoning model of diagnosis and treatment, precision medicine has become a new trend in breast cancer management. Dysregulated glycometabolism is well established as a tumor feature. SDC1 is a glycometabolism-related gene and participates in the progression, metastasis, resistance and recurrence of malignant tumors. SDC1 promotes the development of breast cancer by disturbing tumor stem cell phenotypes, the cell cycle and apoptosis, and then modulates macrophage migration, epithelial-mesenchymal transformation, angiogenesis and the tumor-bone microenvironment. We summarized the recent advances regarding the role of SDC1 in the mechanism driving the occurrence of breast cancer, and evaluated its potential therapeutic contributions.</p>","PeriodicalId":23856,"journal":{"name":"World Journal of Surgical Oncology","volume":"23 1","pages":"193"},"PeriodicalIF":2.5,"publicationDate":"2025-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12082863/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144086855","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Exercise therapy: an effective approach to mitigate the risk of cancer metastasis. 运动疗法:降低癌症转移风险的有效方法。
IF 2.5 3区 医学
World Journal of Surgical Oncology Pub Date : 2025-05-16 DOI: 10.1186/s12957-025-03846-7
Xiaoyan Chen, Junfeng Zhang, Feng Gao, Na Liu, Huijun Du, Jiuhu Li, Zhi Li, Rong Chen
{"title":"Exercise therapy: an effective approach to mitigate the risk of cancer metastasis.","authors":"Xiaoyan Chen, Junfeng Zhang, Feng Gao, Na Liu, Huijun Du, Jiuhu Li, Zhi Li, Rong Chen","doi":"10.1186/s12957-025-03846-7","DOIUrl":"10.1186/s12957-025-03846-7","url":null,"abstract":"<p><p>Cancer metastasis is a primary contributor to cancer-related mortality, and mitigating the risk of metastasis has emerged as a central concern in oncology research. In recent years, exercise therapy, as a non-pharmacological intervention, has received considerable attention for its ability to enhance patients' quality of life and prognosis. Exercise significantly inhibits cancer spread, diminishes cancer risk, and improves therapy outcomes. Nonetheless, the exact mechanisms via which exercise inhibits the dissemination and metastasis of cancer cells are not fully elucidated. This review seeks to examine the mechanisms and prospective research avenues of exercise treatment in mitigating the risk of cancer metastasis. Moreover, it methodically examines pertinent clinical and scientific data, along with the efficacy of exercise therapies in real-world applications. The evaluation moreover suggests future research avenues, including a more profound exploration of mechanisms, the augmentation of clinical trials, the advancement of personalized and precision exercise therapy, and enhanced multidisciplinary collaboration. Exercise therapy shows significant potential in mitigating the risk of cancer metastasis, and its incorporation into holistic cancer treatment frameworks is advised to improve patients' general health and prognostic results.</p>","PeriodicalId":23856,"journal":{"name":"World Journal of Surgical Oncology","volume":"23 1","pages":"192"},"PeriodicalIF":2.5,"publicationDate":"2025-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12082867/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144086796","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Anxiety is a risk prognosis factor for hepatocellular carcinoma with portal vein tumor thrombus who underwent hepatic arterial infusion chemotherapy: a propensity score-matching cohort study. 焦虑是肝动脉输注化疗伴门静脉肿瘤血栓的肝癌患者预后的危险因素:一项倾向评分匹配队列研究。
IF 2.5 3区 医学
World Journal of Surgical Oncology Pub Date : 2025-05-14 DOI: 10.1186/s12957-025-03845-8
Hao-Yang Tan, Shuang-Quan Liu, Yan-Han Liu, Ling Lu, Jiu-Ling Zheng, Hua-Guo Feng
{"title":"Anxiety is a risk prognosis factor for hepatocellular carcinoma with portal vein tumor thrombus who underwent hepatic arterial infusion chemotherapy: a propensity score-matching cohort study.","authors":"Hao-Yang Tan, Shuang-Quan Liu, Yan-Han Liu, Ling Lu, Jiu-Ling Zheng, Hua-Guo Feng","doi":"10.1186/s12957-025-03845-8","DOIUrl":"https://doi.org/10.1186/s12957-025-03845-8","url":null,"abstract":"<p><strong>Background: </strong>Increasing evidence indicates that psychological factors play a role in tumor progression. This study aims to explore the impact of anxiety disorder on the prognosis of hepatocellular carcinoma (HCC) patients with portal vein tumor thrombus (PVTT) who underwent hepatic arterial infusion chemotherapy (HAIC).</p><p><strong>Methods: </strong>A propensity score-matching cohort study was conducted in 68 HCC patients with PVTT who underwent HAIC between January 2020 and December 2023. The anxiety situation was evaluated using the Hamilton Anxiety Rating Scale before HAIC. The objective response rate, overall survival (OS), progression-free survival, and adverse events were compared between the different anxiety score groups. Using Cox proportional hazards models for univariate and multivariate analysis to explore the risk factors of OS.</p><p><strong>Results: </strong>No statistical difference was found in the tumor response, treatment-related adverse events, and PFS between the two groups before and after PSM. Compared with low anxiety scores patients, the OS of obvious anxiety patients was shorter (hazard ratio [HR] = 1.606; 95%CI: 0.868-2.973; P = 0.116). The univariate and multivariate analysis showed that BMI (HR = 1.174, 95%CI: 1.044-1.320; P = 0.007), high anxiety score (HR = 2.769, 95%CI: 1.289-5.947; P = 0.007), and serum ammonia (HR = 1.059; 95%CI: 1.032-1.086; P < 0.001) were independent risk factors of OS.</p><p><strong>Conclusions: </strong>Our study reveals that elevated anxiety scores in HCC patients with PVTT correlated with poor prognosis, indicating that it's a potential prognostic marker. The high anxiety score, BMI, and serum ammonia were independent risk factors of OS.</p>","PeriodicalId":23856,"journal":{"name":"World Journal of Surgical Oncology","volume":"23 1","pages":"189"},"PeriodicalIF":2.5,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12076914/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144080819","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Prognostic value of circadian rhythm-associated genes in breast cancer. 昼夜节律相关基因在乳腺癌中的预后价值。
IF 2.5 3区 医学
World Journal of Surgical Oncology Pub Date : 2025-05-14 DOI: 10.1186/s12957-025-03829-8
Ling Wang, Xiang Gao, Ximeng Zuo, Tangshun Wang, Xiaoguang Shi
{"title":"Prognostic value of circadian rhythm-associated genes in breast cancer.","authors":"Ling Wang, Xiang Gao, Ximeng Zuo, Tangshun Wang, Xiaoguang Shi","doi":"10.1186/s12957-025-03829-8","DOIUrl":"https://doi.org/10.1186/s12957-025-03829-8","url":null,"abstract":"<p><strong>Objective: </strong>Breast cancer (BC) remains the most prevalent malignancy among women. Clinical evidence indicates that genetic variations related to circadian rhythms, as well as the timing of therapeutic interventions, influence the response to radiation therapy and the toxicity of pharmacological treatments in women with BC. This study aimed to identify key circadian rhythm-related genes (CRGs) using bioinformatics and machine learning, and construct a prognostic model to predict clinical outcomes.</p><p><strong>Methods: </strong>Transcriptome data for BC were retrieved from The Cancer Genome Atlas database. Univariate Cox regression and least absolute shrinkage and selection operator regression analyses were used to develop a prognostic model based on CRGs. The predictive performance of the risk score model was evaluated. Univariate and multivariate Cox regression analyses were applied to construct the prognostic model and stratify patients into high-risk and low-risk groups. Additionally, differences in immune microenvironment, immunotherapy efficacy, and tumor mutation burden were assessed between risk groups.</p><p><strong>Results: </strong>A prognostic risk score model comprising 17 CRGs was developed. The areas under the receiver operating characteristic curve for overall survival at 1, 3, 5, and 7 years exceeded 0.6, indicating acceptable predictive performance. Calibration plots and decision curve analyses demonstrated the use of the model in prognostic prediction. Significant differences in immune microenvironment, immunotherapy efficacy, and tumor mutation burden were identified between the low-risk and high-risk groups.</p><p><strong>Conclusion: </strong>The circadian rhythm-based gene model, effectively predicted the prognosis of individuals with BC, highlighting its potential to inform personalized therapeutic strategies and improve patient outcomes.</p>","PeriodicalId":23856,"journal":{"name":"World Journal of Surgical Oncology","volume":"23 1","pages":"186"},"PeriodicalIF":2.5,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12077051/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144080743","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Prognostic value of platelet to lymphocyte ratio in patients with cervical cancer: an updated systematic review and meta-analysis. 宫颈癌患者血小板与淋巴细胞比值的预后价值:一项最新的系统综述和荟萃分析。
IF 2.5 3区 医学
World Journal of Surgical Oncology Pub Date : 2025-05-14 DOI: 10.1186/s12957-025-03838-7
Tianyu Zhu, Zhaoying Chen, Beichen Zhang, Xianqing Wu
{"title":"Prognostic value of platelet to lymphocyte ratio in patients with cervical cancer: an updated systematic review and meta-analysis.","authors":"Tianyu Zhu, Zhaoying Chen, Beichen Zhang, Xianqing Wu","doi":"10.1186/s12957-025-03838-7","DOIUrl":"https://doi.org/10.1186/s12957-025-03838-7","url":null,"abstract":"<p><strong>Background: </strong>The identification of biomarkers that reliably forecast cervical cancer (CC) outcomes is a key area of research. Several studies have explored the link between the platelet-to-lymphocyte ratio (PLR) and cervical cancer prognosis, though the results are not entirely conclusive.</p><p><strong>Methods: </strong>PubMed, Embase, Web of Science, and the Cochrane Library were used to search, with studies published up to May 30, 2024. The selection of studies followed predetermined inclusion and exclusion criteria. Overall survival (OS), progression-free survival (PFS), and disease-free survival (DFS) were primary outcomes. Hazard ratios (HR) and 95% confidence intervals (CIs) were calculated. Sensitivity and subgroup analyses were performed to evaluate the stability and investigate potential heterogeneity. Review Manager version 5.4.1 and STATA version 15.0 were conducted to analyze.</p><p><strong>Results: </strong>Thirty cohort studies, involving 8,597 patients, were included. The pooled data showed that a higher PLR was associated with worse OS significantly (HR = 1.77, 95% CI: 1.43-2.19; p < 0.0001), PFS (HR = 1.69, 95% CI: 1.26-2.27; p = 0.0004), and DFS (HR = 1.57, 95% CI: 1.12-2.18; p = 0.008). Subgroup analysis indicated that the prognostic relevance of PLR was most prominent in patients who underwent both surgery and radiotherapy, as well as those from Asia and the America. Furthermore, a PLR threshold above 150 was associated with improved predictive accuracy.</p><p><strong>Conclusion: </strong>Increased PLR among cervical cancer patients was significantly correlated with reduced OS, PFS, and DFS, pointing to its potential role as an independent prognostic marker. Nonetheless, additional prospective research is required to verify this finding.</p>","PeriodicalId":23856,"journal":{"name":"World Journal of Surgical Oncology","volume":"23 1","pages":"187"},"PeriodicalIF":2.5,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12076899/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144080851","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Correction to: Clinical implications of AGBL2 expression and its inhibitor latexin in breast cancer. 更正:乳腺癌中AGBL2表达及其抑制剂迟发蛋白的临床意义。
IF 2.5 3区 医学
World Journal of Surgical Oncology Pub Date : 2025-05-14 DOI: 10.1186/s12957-025-03831-0
Hao Zhang, Yuan Ren, Deyan Pang, Caigang Liu
{"title":"Correction to: Clinical implications of AGBL2 expression and its inhibitor latexin in breast cancer.","authors":"Hao Zhang, Yuan Ren, Deyan Pang, Caigang Liu","doi":"10.1186/s12957-025-03831-0","DOIUrl":"https://doi.org/10.1186/s12957-025-03831-0","url":null,"abstract":"","PeriodicalId":23856,"journal":{"name":"World Journal of Surgical Oncology","volume":"23 1","pages":"191"},"PeriodicalIF":2.5,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12077036/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144080820","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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