World Journal of Surgical Oncology最新文献

{"title":"Factors associated with declining cytoreductive surgery in advanced epithelial ovarian cancer: a population-based study.","authors":"Lei Zhao, Gang Cheng, Xin Zhou, Congya Xu, Mengni Ge, Qin Zhou","doi":"10.1186/s12957-025-03769-3","DOIUrl":"10.1186/s12957-025-03769-3","url":null,"abstract":"<p><strong>Objective: </strong>Cytoreductive surgery serves as a cornerstone intervention for advanced epithelial ovarian cancer (EOC), yet some patients decline the procedure despite clinical recommendations. This study aimed to evaluate survival outcomes and identify sociodemographic and clinical factors associated with this decision in advanced EOC patients.</p><p><strong>Methods: </strong>A retrospective analysis of EOC cases from the Surveillance, Epidemiology, and End Results (SEER) database (2004-2021) was conducted, including patients with stage III/IV EOC recommended for surgery. Patients were categorized into surgical and non-surgical cohorts. Propensity Score Matching (PSM) was applied to adjust for baseline differences, and survival outcomes were compared using Kaplan-Meier and Cox proportional hazards models. Logistic regression analysis was performed to identify predictors of surgery declination.</p><p><strong>Results: </strong>Of the 21,988 patients included, 363 (1.7%) were in the non-surgery group. Following a median follow-up of 33 months, patients in the non-surgical cohort demonstrated significantly lower overall survival (OS) compared to the surgical cohort, with mean OS of 17.8 months versus 45.8 months, respectively (P < 0.001). The Cox model showed increased mortality risk for the non-surgical group post-PSM (HR, 1.87; 95% CI, 1.62-2.15). Non-Hispanic Black, older age, lower household income, nonmetropolitan residence, and unmarried status were associated with higher odds of surgery refusal.</p><p><strong>Conclusion: </strong>Declining surgery is associated with significantly poorer survival in advanced EOC. Sociodemographic factors play a key role in surgical decision-making, underscoring the need for targeted interventions to improve access to surgical care and reduce disparities in EOC treatment outcomes. Further studies should explore the impact of specific chemotherapy and comorbidities on surgery refusal and survival.</p>","PeriodicalId":23856,"journal":{"name":"World Journal of Surgical Oncology","volume":"23 1","pages":"119"},"PeriodicalIF":2.5,"publicationDate":"2025-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11971787/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143789099","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A pilot study on the clinical feasibility of 5G remote robot-assisted gastrectomy.","authors":"Mingze Zhang, Ming Hu, Jing Yang, Wutang Jing, Jin Guo, Hui Cai, Yuntao Ma","doi":"10.1186/s12957-025-03780-8","DOIUrl":"10.1186/s12957-025-03780-8","url":null,"abstract":"<p><strong>Purpose: </strong>Exploring the Clinical Safety and Feasibility of 5G Remote Surgery Robot-Assisted Gastrectomy.</p><p><strong>Methods: </strong>A retrospective analysis was conducted on the clinical data of two patients who underwent 5G remote surgery robot-assisted gastrectomy at the General Surgery Clinical Center of Gansu Provincial Hospital from June to September 2024. One case involved a cross-provincial remote surgery between Gansu Provincial Hospital and Yangzhou University Affiliated Hospital, located over 1700 km apart, classified as the \"long-distance patient.\" The other case involved a remote surgery within the province, between Gansu Provincial Hospital and the Gansu Provincial Hospital (Lanzhou New District Branch), located 70 km apart, classified as the \"short-distance patient.\" General data, intraoperative conditions, network status, postoperative routine information, and postoperative follow-up data were recorded and analyzed for two patients.</p><p><strong>Result: </strong>Both patients successfully completed the surgery. The master-slave control duration for the long-distance surgery patient and the short-distance surgery patient were 259 min and 308 min, respectively; the total surgical durations were 285 min and 320 min, respectively. Neither patient experienced an intraoperative conversion to traditional surgery. The average total delay for the long-distance surgery patient was 99 ms, and for the short-distance surgery patient, it was 48 ms; the packet loss rates were 0.0188% and 0%, respectively, with no network jitter or interruptions observed. The long-distance surgery patient had a drainage tube retention time of 10 d, a postoperative hospital stay of 14 d. The short-distance surgery patient had a drainage tube retention time of 8 d, a postoperative hospital stay of 10 d. No postoperative complications occurred in either patient.</p><p><strong>Conclusion: </strong>This study suggests that 5G remote surgery is feasible and safe, but larger-scale research is needed.</p>","PeriodicalId":23856,"journal":{"name":"World Journal of Surgical Oncology","volume":"23 1","pages":"117"},"PeriodicalIF":2.5,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11963447/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143773595","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Successful limb-salvage procedure using a bioexpandable prosthesis after infected primary reconstruction of the distal femur in a skeletally immature patient: a case report.","authors":"Jan Lesensky, Ana C Belzarena, Michal Benes","doi":"10.1186/s12957-025-03759-5","DOIUrl":"10.1186/s12957-025-03759-5","url":null,"abstract":"<p><strong>Background: </strong>Periprosthetic infections pose a devastating complication in skeletally immature patients treated for an orthopaedic oncological condition. Reconstructive approaches to revision procedures are often limited, and many cases still require amputation.</p><p><strong>Case presentation: </strong>In this report, we present our unique experience with the bio-expandable MUTARS^® BioXpand prosthesis, utilized during the second stage of a revision surgery in an adolescent female patient. Initially, the patient underwent reconstruction using a conventional endoprosthesis following the resection of a high-grade distal femur osteosarcoma; however, she developed a deep infection six months later. During a two-stage revision procedure, the infection was successfully eradicated at the cost of loss of growth potential at also the site of proximal tibia. The initial 5 cm limb-length discrepancy was restored through the application of bioexpandable endoprosthesis, which allowed for an 8 cm gain in bone stock. At the last follow-up appointment, the patient was fully weight-bearing and demonstrated excellent clinical outcomes, with no evidence of infection or tumor recurrence.</p><p><strong>Conclusion: </strong>This successful limb-salvage procedure indicates that bioexpandable endoprosthesis may serve as a viable and effective reconstructive option in revision surgery for skeletally immature individuals.</p>","PeriodicalId":23856,"journal":{"name":"World Journal of Surgical Oncology","volume":"23 1","pages":"116"},"PeriodicalIF":2.5,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11963633/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143773613","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prognostic and clinicopathological significance of C-reactive protein-albumin-lymphocyte(CALLY) in patients with digestive system neoplasms: a systematic review and meta-analysis.","authors":"Dengzhuo Chen, Yongli Ma, Jinghui Li, Liang Wen, Linfeng Liu, Jiarui Su, Jiawei Wu, Ping Wang, Guosheng Zhang, Chengzhi Huang, Xueqing Yao","doi":"10.1186/s12957-025-03779-1","DOIUrl":"10.1186/s12957-025-03779-1","url":null,"abstract":"<p><strong>Objective: </strong>The prognostic significance of the C-reactive protein-albumin-lymphocyte (CALLY) index in digestive system neoplasms (DSNs) has been investigated in several studies, but inconsistencies remain between the results of different studies. Therefore, the aim of this study was to confirm the prognostic significance of CALLY in patients with DSNs and its association with clinicopathological characteristics (CPCs).</p><p><strong>Methods: </strong>The databases PubMed, Cochrane Library, Web of Science, Research Square and Embase were systematically searched for clinical trials with databases up to 1 November 2024. The value of CALLY in predicting overall survival (OS), disease-free survival (DFS) and recurrence-free survival (RFS) versus cancer-specific survival (CSS) in patients with DSNs was confirmed by calculating the combined hazard ratio (HR) and 95% CI. The combined OR and 95% CI were calculated to assess the association between CALLY and CPCs in patients with DSNs.</p><p><strong>Results: </strong>A total of 18 studies with 7916 patients with DSNs were included in this study. Pooled analysis showed that lower CALLY was associated with poor OS, DFS, RFS and CSS were significantly associated. In addition, low CALLY index was associated with male gender, T3-T4, lymph node metastasis, lymph vessel invasion, complications, stage III-IV and surgical approach were significantly associated. However, there was no association between low CALLY index and histological type, adjuvant chemotherapy, and neoadjuvant chemotherapy.</p><p><strong>Conclusions: </strong>In this meta-analysis, a low CALLY index was significantly associated with poor OS, DFS, RFS and CSS in patients with DSNs and with several CPCs in patients with DSNs.</p><p><strong>Systematic review registration: </strong>PROSPERO CRD42024622973.</p>","PeriodicalId":23856,"journal":{"name":"World Journal of Surgical Oncology","volume":"23 1","pages":"114"},"PeriodicalIF":2.5,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11963618/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143773605","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"DCC-2036 inhibits osteosarcoma via targeting HCK and the PI3K/AKT-mTORC1 axis to promote autophagy.","authors":"Jun He, Liyang Yin, Qiong Yuan, Xiaotao Su, Yingying Shen, Zhongliang Deng","doi":"10.1186/s12957-025-03778-2","DOIUrl":"10.1186/s12957-025-03778-2","url":null,"abstract":"<p><strong>Background: </strong>Osteosarcoma is a common bone tumor in adolescents and children, characterized by rapid progression, high malignancy, poor prognosis, and a tendency for pulmonary metastasis. Despite extensive research efforts, the specific driver gene associated with osteosarcoma remains unidentified, underscoring the urgent need for novel therapeutic targets and targeted treatment options.</p><p><strong>Methods: </strong>In vitro studies were conducted to assess the effects of DCC-2036 on the proliferation, migration, and invasion of osteosarcoma (OS) cell lines, employing cloning and Transwell experiments. Network pharmacological analysis, complemented by in vitro experimental validation, indicated the critical target responsible for the inhibitory effects of DCC-2036. RNA sequencing analysis demonstrated that DCC-2036 could induce autophagy in OS cells, with relative protein levels assessed using Western blotting following treatment with the autophagy inhibitor 3-MA and the mTOR agonist MHY1485. In vivo studies further confirmed the role of DCC-2036 in cell proliferation through subcutaneous tumorigenesis.</p><p><strong>Results: </strong>In this study, we demonstrated that the small molecule tyrosine kinase inhibitor DCC-2036 effectively inhibited osteosarcoma (OS) cells in both cellular and animal models. We found that DCC-2036 significantly suppressed the proliferation of osteosarcoma cells and induced apoptosis; additionally, it notably inhibited cell migration, invasion, and epithelial-to-mesenchymal transition (EMT). HCK was identified as the key target mediating the effects of DCC-2036 on osteosarcoma. Mechanistically, DCC-2036 was shown to inhibit the expression of phosphorylated AKT (p-AKT), phosphorylated S6 kinase (p-S6K), and phosphorylated 4E-binding protein 1 (p-4EBP1) within the downstream PI3K/AKT/mTORC1 signaling pathway. Furthermore, in vivo experiments utilizing subcutaneous tumor xenografts in mice demonstrated that DCC-2036 effectively inhibited the growth of xenografted 143B cells in BALB/C-nude mice.</p><p><strong>Conclusions: </strong>Collectively, these findings indicate that DCC-2036 promotes autophagy in osteosarcoma (OS) cells by targeting the HCK/AKT/mTORC1 axis and exerts anti-tumor effects without significant toxicity. Consequently, DCC-2036 emerges as a promising therapeutic agent for the treatment of HCK-overexpressing osteosarcoma.</p>","PeriodicalId":23856,"journal":{"name":"World Journal of Surgical Oncology","volume":"23 1","pages":"115"},"PeriodicalIF":2.5,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11963706/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143773598","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"eIF6: a promising therapeutic target for gastric carcinoma via PI3K/AKT pathway modulation.","authors":"Shuang Hou, Hao Tang, Zhikun Dong, Wence Zhou","doi":"10.1186/s12957-025-03746-w","DOIUrl":"10.1186/s12957-025-03746-w","url":null,"abstract":"<p><strong>Background: </strong>Gastric carcinoma (GC) is a leading cause of cancer-related deaths, with a dire prognosis for advanced stages. The molecular mechanisms underlying GC progression are not fully understood, necessitating research into novel biomarkers and therapeutic targets. This study investigates the role of eukaryotic translation initiation factor 6 (eIF6) in GC, focusing on its potential as a prognostic indicator and its impact on tumor biology.</p><p><strong>Methods: </strong>We analyzed eIF6 expression in GC tissues using data from TCGA and GEO databases. Experiments included western blot, IHC staining, and cell culture assays on GC cell lines to evaluate the effect of eIF6 on cell proliferation, invasion, and apoptosis. Statistical analyses were performed using Student's t-tests and ANOVA, with significance set at p < 0.05.</p><p><strong>Results: </strong>eIF6 was found to be significantly overexpressed in GC tissues, associated with advanced tumor stage and poor patient survival. Functional assays demonstrated that eIF6 knockdown inhibits GC cell proliferation and invasion while promoting apoptosis. Transcriptomic analysis linked eIF6 to the PI3K/AKT pathway, a critical regulator in cancer.</p><p><strong>Conclusions: </strong>eIF6's overexpression in GC suggests its role in tumor progression, highlighting its potential as a therapeutic target. The study provides a foundation for developing targeted therapies against eIF6 and emphasizes the need for further research into its regulatory mechanisms in GC.</p>","PeriodicalId":23856,"journal":{"name":"World Journal of Surgical Oncology","volume":"23 1","pages":"113"},"PeriodicalIF":2.5,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11963666/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143765258","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pancreatic atrophy after gastric cancer surgery: influencing factors and effects on BMI and quality of life.","authors":"Zhaoping Li, Lianlian Cao, Hao Chen, Feng Wang, Liang Tao, Meng Wang","doi":"10.1186/s12957-025-03761-x","DOIUrl":"10.1186/s12957-025-03761-x","url":null,"abstract":"<p><strong>Background: </strong>Pancreatic atrophy can occur after gastric cancer surgery, but the influencing factors and effects of pancreatic atrophy have not been extensively studied. The aim of this study was to investigate the factors of pancreatic atrophy after gastric cancer surgery and to assess the effect of atrophy on BMI and quality of life, in order to promote postoperative management of patients with higher risk factors of pancreatic atrophy.</p><p><strong>Methods: </strong>Clinical data pertaining to 142 patients who underwent surgery for gastric cancer were retrospectively collected, and pancreatic volume was determined using abdominal computed tomography data. Influencing factors of pancreatic atrophy were analysed and the relationship of pancreatic atrophy to BMI and quality of life was measured. Correlation analysis using Pearson or Spearman rank correlation and multiple linear regression were used to analyse the risk factors influencing pancreatic atrophy.</p><p><strong>Results: </strong>Pancreatic atrophy was significant in patients with gastric cancer 1 year after surgery, regardless of the surgical procedure. T3 and T4 stages, preoperative low levels of high-density lipoprotein cholesterol(HDL-C) and smoking history were influencing factors of pancreatic atrophy. Pancreatic atrophy was associated with reduced BMI and deterioration of quality of life.</p><p><strong>Conclusions: </strong>Clinicians need to monitor pancreatic function, BMI and life quality more carefully in gastric cancer patients with T3 and T4 stages, preoperative low levels of HDL-C and smoking history.</p>","PeriodicalId":23856,"journal":{"name":"World Journal of Surgical Oncology","volume":"23 1","pages":"112"},"PeriodicalIF":2.5,"publicationDate":"2025-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11956482/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143754795","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Targeting NETO2 suppresses cell proliferation, invasion, and migration and inactivates the STAT3/C-MYC pathway in hepatocellular carcinoma.","authors":"Na Shun Meng He, Xinghua Wu, Shu Chen, Xinyi Yun, Shun Yao, Hai Yu","doi":"10.1186/s12957-025-03717-1","DOIUrl":"10.1186/s12957-025-03717-1","url":null,"abstract":"<p><strong>Background: </strong>Neuropilin and tolloid-like 2 (NETO2) facilitates the progression of various cancers, but its role in hepatocellular carcinoma (HCC) is not known. This study aimed to assess the potential of targeting NETO2 in HCC and its relationship with the STAT3/C-MYC pathway.</p><p><strong>Methods: </strong>HCC cells (Huh7 and MHCC-97 H) were cultured and transfected with control siRNA (siCtrl), NETO2 siRNA (siNETO2), control overexpression (oeCtrl), or NETO2 overexpression (oeNETO2), with non-transfected cells used as blank controls.</p><p><strong>Results: </strong>NETO2 mRNA and protein expressions were reduced in both Huh7 and MHCC-97 H cells. EdU and CCK-8 assays indicated that cell proliferation was decreased after siNETO2 transfection in Huh7 and MHCC-97 H cells. TUNEL assay found revealed that the cell apoptosis rate was greater after siNETO2 transfection in MHCC-97 H cells, and tended to be greater in Huh7 cells (but the difference was not statistically significant). Transwell invasion assay revealed that the number of invasive Huh7 and MHCC-97 H cells decreased after siNETO2 transfection. Cell scratch assay revealed that the cell migration rate was reduced after siNETO2 transfection in Huh7 cells but was not significantly different in MHCC-97 H cells. Western blotting revealed that p-STAT3 and C-MYC expressions were decreased after siNETO2 transfection in Huh7 and MHCC-97 H cells. Overexpression experiments revealed that cell proliferation and invasion were promoted but that the cell apoptosis rate was reduced after oeNETO2 transfection in Huh7 and MHCC-97 H cells.</p><p><strong>Conclusion: </strong>NETO2 knockdown suppresses HCC cell proliferation, invasion, and migration and inactivates the STAT3/C-MYC pathway, suggesting that NETO2 is a potential target for HCC treatment.</p>","PeriodicalId":23856,"journal":{"name":"World Journal of Surgical Oncology","volume":"23 1","pages":"107"},"PeriodicalIF":2.5,"publicationDate":"2025-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11954197/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143744061","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical outcomes of double-flap technique versus gastric tube reconstruction following laparoscopic proximal gastrectomy: a multicenter propensity score-matched cohort study.","authors":"Zhu Jingtao, Chen Shaoqin, Zhang Tao, Yang Li, You Sheng, Hong Qingqi, Lin Hexin, Chen Yinan, Yu Huangdao, Chen Yifu, Yu Xuejun, You Jun","doi":"10.1186/s12957-025-03672-x","DOIUrl":"10.1186/s12957-025-03672-x","url":null,"abstract":"<p><strong>Background: </strong>Various anti-reflux procedures are currently utilized for digestive tract reconstruction following proximal gastrectomy (PG), but the optimal reconstruction method remains debated. This study aims to compare and analyze the clinical outcomes and postoperative quality of life between double-flap technique (DFT) and gastric tube (GT) reconstruction after laparoscopic proximal gastrectomy (LPG), providing a reference for selecting the appropriate digestive tract reconstruction method.</p><p><strong>Methods: </strong>This multicenter, retrospective cohort study employed propensity score matching (PSM) to address baseline imbalances. Clinical, pathological, and follow-up data were collected from 124 patients who underwent either LPG-GT or LPG-DFT between January 2016 and May 2023 at four medical centers in China. The surgical outcomes, incidence of postoperative gastroesophageal reflux and anastomotic stricture, postoperative nutritional status, and quality of life were compared between the two groups.</p><p><strong>Results: </strong>After 1:1 PSM, 41 patients were included in each group for analysis. Compared to the LPG-GT group, the LPG-DFT group had a longer operation time (340.0 min vs. 280.0 min, P < 0.001) but less intraoperative blood loss (80.0 ml vs. 100.0 ml, P < 0.001), a shorter time to nasogastric tube removal (3.0 days vs. 5.0 days, P < 0.001), and shorter postoperative hospital stay (9.0 days vs. 12.0 days, P < 0.001). The incidence of gastroesophageal reflux in the LPG-DFT and LPG-GT groups was 7.3% and 24.3% (P = 0.034), respectively, and the incidence of anastomotic stricture requiring dilation was 14.6% and 7.3% (P = 0.480). One year postoperatively, BMI (22.0 kg/m² vs. 20.6 kg/m², P = 0.010) and albumin levels at six months postoperatively (41.6 g/L vs. 39.1 g/L, P = 0.033) were significantly higher in the LPG-DFT group. However, albumin levels one year postoperatively showed no significant difference between the two groups (42.3 g/L vs. 40.7 g/L, P = 0.226).</p><p><strong>Conclusion: </strong>The surgical outcomes suggest that both LPG-GT and LPG-DFT are safe and feasible methods. However, LPG-DFT provides better anti-reflux effects and may help reduce the risk of postoperative malnutrition.</p>","PeriodicalId":23856,"journal":{"name":"World Journal of Surgical Oncology","volume":"23 1","pages":"110"},"PeriodicalIF":2.5,"publicationDate":"2025-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11954176/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143744070","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"AEBP1 inhibition reduces cell growth and PI3K/AKT pathway while less regulates cell mobility in hepatocellular carcinoma.","authors":"Liyou Liu, Qingshan Cai, Dongyang Wu, Shudong Li, Dong Liu, Jianxing Zheng","doi":"10.1186/s12957-025-03750-0","DOIUrl":"10.1186/s12957-025-03750-0","url":null,"abstract":"<p><strong>Background: </strong>Adipocyte enhancer-binding protein 1 (AEBP1) regulates collagen fibrosis, extracellular matrix, and important oncogene pathways, but its regulation on hepatocellular carcinoma (HCC) is not known. This study aimed to investigate the effect of AEBP1 knockdown on HCC cell proliferation, apoptosis, migration, invasion and PI3K/AKT pathway.</p><p><strong>Methods: </strong>MHCC-97 H and Huh7 cell lines were applied. Negative control or AEBP1 siRNA (siAEBP1) were transfected into cells, and cells without transfection were set as blank control. Quantitative polymerase chain reaction (qPCR), western blot, Cell Counting Kit-8 (CCK-8), 5-Ethynyl-2'-deoxyuridine (EdU) staining, Terminal-deoxynucleotidyl Transferase Mediated Nick End Labeling (TUNEL) staining, Transwell invasion, and cell scratch assays were performed.</p><p><strong>Results: </strong>AEBP1 mRNA and protein expressions were lower after siAEBP1 transfection in MHCC-97 H and Huh7 cells. OD value of CCK-8 and EdU positive cell percentage were decreased, while TUNEL reflected cell apoptosis rate was increased, after siAEBP1 transfection in MHCC-97 H and Huh7 cells. However, invasive cell number and cell migration rate were only reduced after siAEBP1 transfection in Huh7 cells but not in MHCC-97 H cells. Expressions of p-PI3K/PI3K and p-AKT/AKT were downregulated after siAEBP1 transfection in MHCC-97 H and Huh7 cells. Subsequent rescue experiment revealed that th activation of PI3K/AKT pathway by 740Y-P attenuated the effect of siAEBP1 transfection in MHCC-97 H and Huh7 cells.</p><p><strong>Conclusion: </strong>AEBP1 exhibits the potency to be a target for HCC treatment, reflected by its regulation on HCC proliferation, apoptosis and PI3K/AKT pathway, but its effect on HCC invasion and migration seems limited.</p>","PeriodicalId":23856,"journal":{"name":"World Journal of Surgical Oncology","volume":"23 1","pages":"108"},"PeriodicalIF":2.5,"publicationDate":"2025-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11954352/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143744068","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}