{"title":"Association of progesterone receptor status with breast cancer prognosis: a meta-analysis.","authors":"Yiming Hou, Jianrong Li, Qiong Zhang, Yingyi Fan","doi":"10.1186/s12957-025-04001-y","DOIUrl":"10.1186/s12957-025-04001-y","url":null,"abstract":"<p><strong>Background: </strong>Breast cancer (BC) prognosis is influenced by hormones, of which progesterone receptor (PR) status is controversial for BC prognosis, possibly related to clinical characteristics.</p><p><strong>Objective: </strong>This study was to determine the impact of PR status on BC prognosis and explore the differences across patient subgroups.</p><p><strong>Methods: </strong>PubMed, Cochrane Library, Embase, and Web of Science were searched for relevant studies until July 2024. NOS (Newcastle-Ottawa Scale) was leveraged for quality appraisal. Meta-analysis was performed using STATA15.1.</p><p><strong>Results: </strong>Thirty-five studies were included, involving 89,164 patients. PR-negative status was associated with worse overall survival compared to PR-positive status (HR 1.70, 95%CI 1.42 to 2.04; p < 0.001). Similar results were unveiled for disease-free survival (HR 1.62, 95%CI 1.23 to 2.14, p < 0.001), breast-cancer-specific survival (HR 2.45, 95% CI 1.85 to 3.23, p < 0.001), and recurrence-free survival (HR 1.47, 95% CI 1.21 to 1.79, p < 0.001). Subgroup analyses unveiled that conclusions were influenced by region, estrogen receptor (ER) status, human epidermal growth factor receptor 2 (HER2) status, menopausal status, and metastatic status.</p><p><strong>Conclusion: </strong>PR loss is associated with worse outcomes in BC, which is influenced by clinical characteristics. Especially in patients with ER + HER2- tumors, PR status may serve as an additional predictive marker.</p>","PeriodicalId":23856,"journal":{"name":"World Journal of Surgical Oncology","volume":"23 1","pages":"356"},"PeriodicalIF":2.5,"publicationDate":"2025-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12490167/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145207899","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Zaisheng Zhu, Yiyi Zhu, Wenmin Ying, Han Wu, Penfei Zhou, Quanqi Liu, Jianyong Tong, Yueping Wang
{"title":"Comparison of the anti-reflux ileum valve-pouch orthotopic neobladder and the Studer technique after radical cystecomy: surgical and renal functional outcomes.","authors":"Zaisheng Zhu, Yiyi Zhu, Wenmin Ying, Han Wu, Penfei Zhou, Quanqi Liu, Jianyong Tong, Yueping Wang","doi":"10.1186/s12957-025-03699-0","DOIUrl":"10.1186/s12957-025-03699-0","url":null,"abstract":"<p><strong>Background: </strong>This study describes the construction of an anti-reflux neobladder using an ileum valve-pouch (IVP) and compares its efficacy with that of the modified Studer-pouch (MSP).</p><p><strong>Methods: </strong>This study included a total of 127 patients who underwent radical cystectomy + neobladder construction (IVP: n = 66; MSP = 61) between January 2015 and June 2023 at two major medical centers in our city. Potential bias was reduced by 1:1 propensity score matching (PSM) to compare oncology, complications, and renal function protection between the two groups. The estimated glomerular filtration rate (eGFR) was calculated using the CKD-EPI (Chronic Kidney Disease Epidemiology Collaboration) equation. Survival was assessed using Kaplan-Meier analysis.</p><p><strong>Results: </strong>The median follow-up time was 44.5 and 35.5 months in the IVP and MSP groups, respectively. After propensity scoring, 84 patients (42 in each group) were included in the analysis.There was no significant statistical difference in the operation time(p = 0.128) and the time of urinary diversion (p = 0.354) between the two groups.Kaplan-Meier curves showed no significant differences in cancer-specific survival (CSS) (p = 0.181) and overall survival (OS) (p = 0.611) between the two groups. In addition, the total complications and renal function were not statistically different between the two groups (p > 0.05). The incidence of patients who needed to be re-hospitalized due to urinary tract infection was lower in the VIP group than in the MSP group (p = 0.039). At 12 months postoperatively, lower rates of decreased eGFR and renal function damage were observed in the IVP group compared to the MSP group (p = 0.031 and < 0.001), which were significantly related to the type of neobladder (p = 0.004) and preoperative eGFR values (p < 0.001).</p><p><strong>Conclusion: </strong>The preliminary results of VIP technique are safe and effective. It does not increase the time of anti-reflux construction. The incidence of complications similar in the two groups. However, the protection of renal function at 12 months after surgery seemed to be superior to MSP.The independent factors affecting renal function damage are neobladder type and preoperative eGFR.</p>","PeriodicalId":23856,"journal":{"name":"World Journal of Surgical Oncology","volume":"23 1","pages":"359"},"PeriodicalIF":2.5,"publicationDate":"2025-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12492917/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145213768","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Safety and pathological impact of resection after high-dose PBT for locally advanced pancreatic cancer.","authors":"Osamu Shimomura, Haruko Numajiri, Shinji Hashimoto, Yoshihiro Miyazaki, Manami Doi, Hiromitsu Nakahashi, Kazuhiro Takahashi, Yuichi Hiroshima, Naoyuki Hasegawa, Masato Endo, Yusuke Niisato, Yuya Hagiwara, Yoshiyuki Yamamoto, Takeshi Yamada, Noriaki Sakamoto, Daisuke Matsubara, Bryan J Mathis, Kiichiro Tsuchiya, Hideyuki Sakurai, Tatsuya Oda","doi":"10.1186/s12957-025-03992-y","DOIUrl":"10.1186/s12957-025-03992-y","url":null,"abstract":"<p><strong>Background: </strong>A multidisciplinary approach is essential for treating lethal pancreatic cancer. Proton beam therapy (PBT), with its potential for dose escalation, shows promising effect for the local tumor, but the safety of subsequent resection and its pathological impact remain uncertain.</p><p><strong>Methods: </strong>A retrospective single-center analysis was conducted on patients with locally advanced pancreatic cancer who underwent multidisciplinary treatment, including PBT, chemotherapy and hyperthermia (January 2014 to December 2022). PBT target dose was 67.5 Gy concurrently gemcitabine infusion and local hyperthermia was applied 1 h after gemcitabine infusion. The standard chemo regimens (such as gemcitabine with nab-paclitaxel or FOLFIRINOX) followed triple-modal treatment. Surgical complications, pathological assessment and survival were analyzed in resected cases.</p><p><strong>Results: </strong>Among 133 patients treated with PBT, 110 underwent triple-modal treatment combining PBT, hyperthermia, and chemotherapy. Ultimately, 11 patients underwent tumor resection after a median preoperative treatment duration of 210 days. Surgical procedures included five pancreaticoduodenectomies and six distal pancreatectomies. Three patients experienced complications of Clavien-Dindo grade 3 or higher (2; delayed gastric empty, 1; pancreatic fistula), but no mortality occurred. Histological evaluations revealed three cases of Grade 4 (27%, pathological complete response), four of Grade 3, three of Grade 2, and one of Grade 1. R0 resection was achieved in 10 cases.</p><p><strong>Conclusions: </strong>Surgical resection following high-dose PBT can be safely performed under strict selection criteria and demonstrates strong pathological disease control of the primary tumor. This multidisciplinary approach may offer improved outcomes for locally advanced pancreatic cancer.</p>","PeriodicalId":23856,"journal":{"name":"World Journal of Surgical Oncology","volume":"23 1","pages":"352"},"PeriodicalIF":2.5,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12486620/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145201210","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Postoperative bladder training in patients with mid-low rectal cancer facilitates early removal of the urinary catheter: a prospective, randomized, open-label, blinded-endpoint trial.","authors":"Yongsen Wang, Yuezhi Chen, Xin Zhang, Jizhun Zhang","doi":"10.1186/s12957-025-03991-z","DOIUrl":"10.1186/s12957-025-03991-z","url":null,"abstract":"<p><strong>Background: </strong>To evaluate whether intermittent catheterization for bladder training can reduce urinary catheterization duration in patients undergoing mid-low rectal cancer surgery.</p><p><strong>Methods: </strong>Stratified by gender, 330 patients were divided into a 5-day catheterization control group, and experimental groups A (3-day bladder training) and B (5-day bladder training), with 110 patients each.</p><p><strong>Results: </strong>Two-way ANOVA found that gender affected recatheterization, Pdet@Qmax, Qmax, BOOI and three-day total urine volume. No difference between groups A and B. Patients in experimental group A had a shorter time to first void (P = 0.030) and lower three-day average residual urine volume (P = 0.011) than the control group, and patients in experimental group B had a larger urine volume (P = 0.043) and lower first residual urine volume (P = 0.001). Bladder training reduced recatheterization in males. The nomogram constructed based on the logistic regression model better predicted the risk of urinary tract infection (AUC = 0.669) and recatheterization (AUC = 0.731). These two models may help provide new tools for the postoperative care of patients with mid-low rectal cancer.</p><p><strong>Conclusions: </strong>Three-day catheter removal after bladder training is non-inferior to five-day removal. Bladder training is effective in reducing the chances of recatheterization in patients with mid-low rectal cancer.</p><p><strong>Trial registration: </strong>This study was registered with the China Clinical Trials Registry at 22th March, 2018 (No. ChiCTR1800015313, https://www.chictr.org.cn/showproj.html?proj=26123 ).</p>","PeriodicalId":23856,"journal":{"name":"World Journal of Surgical Oncology","volume":"23 1","pages":"353"},"PeriodicalIF":2.5,"publicationDate":"2025-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12487385/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145201202","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Yuan Yang, Haifeng Lin, Liang Shi, Xinjie Yang, Mingming Hu, Li Tong, Zhe Liu, Jing Yu, Baohua Lu
{"title":"The characteristics and prognoses of 72 postoperative synchronous multiple primary lung cancer patients.","authors":"Yuan Yang, Haifeng Lin, Liang Shi, Xinjie Yang, Mingming Hu, Li Tong, Zhe Liu, Jing Yu, Baohua Lu","doi":"10.1186/s12957-025-03964-2","DOIUrl":"10.1186/s12957-025-03964-2","url":null,"abstract":"<p><strong>Purpose: </strong>Synchronous multiple primary lung cancer (SMPLC) is a special type. Currently, there are few reports on the clinical characteristics, genetic status, treatment strategies, and prognosis of SMPLC after radical surgery.</p><p><strong>Methods: </strong>We retrospectively reviewed cases of SMPLC patients from January 2018 to October 2023. All patients underwent radical surgery and had genetic results using Next-generation sequencing (NGS) or Amplification refractory mutation system polymerase chain reaction (ARMS-PCR) for at least one lesion. Analysis was conducted on the clinical information, pathological types, genetic status, treatment strategies, and prognoses.</p><p><strong>Results: </strong>We analyzed 72 patients with SMPLC in stage I-IIIA, and 64 of them were in stage IA. Epidermal growth factor receptor (EGFR) mutation was the most common gene, followed by Tumor protein 53(TP53) and Kirsten Rat sarcoma viral oncogene homolog (KRAS). Among the population with EGFR mutations, EGFR L858R, EGFR 19DEL, and EGFR G719X are common, accounting for 47.6%, 33.3%, and 7.2%, respectively. Among the 72 patients, 66 were lung cancer-free with a median follow-up time of 32 months and six patients experienced disease recurrence with a median Disease-free survival (DFS) of 24 months. For stage IA patients, DFS was correlated with the presence of pathological high-risk factors (combined small cell lung cancer, solid/micropapillae subtype) (P<0.001) and PD-L1 expression (P = 0.008), but was not correlated with the number of primary lesions, pathological stage (IA1, IA2, IA3), TP53/KRAS mutation, or status of EGFR sensitive mutation.</p><p><strong>Conclusion: </strong>EGFR is a high-frequency mutation in early stage SMPLC. Radical surgery is a suitable treatment strategy for stage IA SMPLC patients, including those with EGFR sensitive mutations. Pathological high-risk factors and PDL-1 positive expression correlate with poorer prognoses in stage IA patients.</p>","PeriodicalId":23856,"journal":{"name":"World Journal of Surgical Oncology","volume":"23 1","pages":"355"},"PeriodicalIF":2.5,"publicationDate":"2025-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12487339/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145201287","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Risk factors and prognosis of postoperative early relapse after neoadjuvant therapy for locally advanced esophageal squamous cell carcinoma: a retrospective study.","authors":"Ze-Gang Chen, Yue-Yun Chen, Zhen Lin, Pan-Pan Lin, Qing Li, Yu-Shang Yang, Hua-Shan Shi, Zhen-Yu Ding","doi":"10.1186/s12957-025-03985-x","DOIUrl":"10.1186/s12957-025-03985-x","url":null,"abstract":"<p><strong>Background: </strong>This study aimed to identify risk factors associated with early postoperative relapse and evaluate their impact on survival outcomes after neoadjuvant therapy for locally advanced esophageal squamous cell carcinoma (LA-ESCC), thereby informing strategies to optimize postoperative clinical management.</p><p><strong>Methods: </strong>Patients with LA-ESCC who underwent neoadjuvant therapy followed by surgical resection at West China Hospital between January 2018 and December 2023 were screened and enrolled. Patients were categorized into early relapse (≤ 6 months) and late relapse (> 6 months) groups based on the interval from surgery to relapse.</p><p><strong>Results: </strong>A total of 183 LA-ESCC patients who received neoadjuvant therapy followed by surgical resection were included, with 79 experiencing early relapse and 104 experiencing late relapse. Logistic regression analysis showed that postoperative TNM stage III-IV, ypN + stage, R1 resection, lymphovascular invasion (LVI), perineural invasion (PI), and absence of postoperative adjuvant therapy were risk factors for early relapse (p < 0.05). Multivariate regression further identified R1 resection as an independent predictor (p < 0.05). Cox regression analysis demonstrated that LI was a prognostic factor for overall survival (OS) in patients with early relapse (p = 0.045). Kaplan-Meier analysis revealed significantly reduced OS (12.5 months vs. 26.9 months, HR = 2.96, p < 0.001) and survival after relapse (SAR) (5.9 months vs. 11.0 months, HR = 1.81, p < 0.001) in the early relapse group compared to the late relapse group. However, relapse patterns did not differ significantly between groups (p > 0.05).</p><p><strong>Conclusion: </strong>R1 resection is an independent risk factor for rapid postoperative relapse in LA-ESCC patients following neoadjuvant therapy. Furthermore, LVI significantly affects patients survival outcomes, and early relapse was strongly associated with reduced overall survival (OS).</p>","PeriodicalId":23856,"journal":{"name":"World Journal of Surgical Oncology","volume":"23 1","pages":"354"},"PeriodicalIF":2.5,"publicationDate":"2025-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12487306/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145201229","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Effect and clinical significance of bilateral thoracic paravertebral block combined with S-ketamine on laparoscopic radical surgery for colorectal cancer.","authors":"Tongqiang Cai, Meixia Li, Qingxia Yan","doi":"10.1186/s12957-025-03999-5","DOIUrl":"10.1186/s12957-025-03999-5","url":null,"abstract":"<p><strong>Objective: </strong>To analyze the effect of bilateral thoracic paravertebral block (TPVB) combined with s-ketamine on patients undergoing laparoscopic radical surgery for colorectal cancer (CRC).</p><p><strong>Methods: </strong>The study subjects were 94 patients who visited our hospital for colon cancer and underwent laparoscopic radical surgery from January 2022 to January 2024. The patients were divided into the Control group (n = 33), TPVB group that underwent bilateral TPVB (n = 30) and Combine group that underwent TPVB + s-ketamine (n = 31). The haemodynamic indexes of patients were monitored and compared; the Stress Response Indicators of patients were detected by ELISA, pain at rest and during exercise was assessed by numerical rating scale (NRS), cognitive level was assessed by Mini-Mental State Examination (MMSE), and perioperative daily living ability was assessed by Activity Daily Living (ADL) Scale; quality of life assessed by the 12-item Short-Form Health Survey (SF-12); and the overall patient outcomes were statistically compared.</p><p><strong>Results: </strong>➀ Haemodynamic improvement was significantly greater than that in the Control and TPVB groups (P < 0.05). ➁ Stress response indicators (cortisol [COR] and adrenocorticotropic hormone [ACTH]) decreased more markedly in the Combine group than in the Control and TPVB groups (P < 0.05). ➂ The Combine group showed more pronounced declines in resting and exercise-induced NRS scores, as well as more significant increases in ADL and MMSE scores, compared with the Control and TPVB groups (P < 0.05). ➃ Although no significant differences in SF-12 scores were observed among the Control, TPVB, and Combine groups, all three groups exhibited substantial improvements in quality of life at 3, 6, and 9 months post-surgery (P > 0.05). ➄ The Combine group had significantly shorter times to first flatus, first solid food intake, and first defecation, as well as reduced hospital stay duration, propofol dosage, and remifentanil dosage, compared with the TPVB and Control groups (P < 0.05). ➅ The complication rates in the Combine and TPVB groups were significantly lower than those in the Control group (P < 0.05).</p><p><strong>Conclusion: </strong>TPVB combined with s-ketamine can effectively eliminate patients' pain and stress and improve their haemodynamics, which further promotes patients' postoperative recovery.</p>","PeriodicalId":23856,"journal":{"name":"World Journal of Surgical Oncology","volume":"23 1","pages":"347"},"PeriodicalIF":2.5,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12482895/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145193304","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"SUZ12 knockdown restrains the proliferation, migration, and invasion of oral tongue squamous cell carcinoma through inhibiting DNMT1-mediated ZNF582 promoter methylation.","authors":"Xiangwei Kong, Yicheng Cheng, Lin Zhang, Wei Yin, Chenchen Wang, Zhan'ao Wu","doi":"10.1186/s12957-025-04015-6","DOIUrl":"10.1186/s12957-025-04015-6","url":null,"abstract":"<p><strong>Background: </strong>Suppressor of zest 12 (SUZ12) upregulation is related to cervical node metastasis in oral tongue squamous cell carcinoma (OTSCC). This study explored the roles and mechanism of SUZ12 in OTSCC progression.</p><p><strong>Methods: </strong>SUZ12 protein levels in OTSCC tissues and cell lines were determined using immunohistochemistry assay and Western blot analysis. SUZ12 was overexpressed or silenced through transfection of Overexpression plasmids or small interfering RNA targeting SUZ12 were transfected into CAL27 and SCC9 cells to achieve SUZ12 overexpression or knockdown. Subsequently, cell proliferation, migration, invasion, and epithelial-mesenchymal transition (EMT) markers (E-cadherin, N-cadherin and Vimentin) were determined. Zinc finger protein 582 (ZNF582) promoter methylation was detected using the methylation-specific PCR assay. Then, the effects of ZNF582 on CAL27 cell behaviors were also evaluated using gain/loss function experiments. Moreover, rescue experiments were conducted to investigate the role of the SUZ12/ZNF582 axis in regulating CAL27 cell progression. Additionally, SUZ12-silenced CAL27 cells were subcutaneously injected into the posterior flank of mice, followed by tumor growth detection within a 28 day period.</p><p><strong>Results: </strong>SUZ12 protein was significantly upregulated in OTSCC tissues and cell lines. SUZ12 overexpression augmented proliferation, migration, invasion and EMT in both CAL27 and SCC9 cells, while SUZ12 knockdown showed the opposite results. SUZ12 inhibited ZNF582 expression by promoting DNA methyltransferase 1 (DNMT1)-mediated ZNF582 promoter methylation. Moreover, ZNF582 knockdown promoted OTSCC cell proliferation, migration, invasion and EMT, while ZNF582 overexpression led to the opposite results. Rescue experiments demonstrated that ZNF582 knockdown abrogated SUZ12 knockdown-mediated inhibition of CAL27 cell malignant progression. Besides, SUZ12 knockdown suppressed xenograft tumor growth of OTSCC in nude mice.</p><p><strong>Conclusion: </strong>SUZ12 knockdown inhibits the proliferation, migration, invasion and EMT in OTSCC cells by inhibiting DNMT1-mediated ZNF582 promoter methylation, thereby suppressing tumor growth in vivo.</p>","PeriodicalId":23856,"journal":{"name":"World Journal of Surgical Oncology","volume":"23 1","pages":"350"},"PeriodicalIF":2.5,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12482123/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145193342","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Application of preoperative three-dimensional reconstruction in single-port video-assisted thoracoscopic complex segmentectomy: a propensity matching analysis.","authors":"Hao Chen, Wenjie Yuan, Zhonghua Wu, Wenxin Liang, Yuanpu Wei, Yu Huang, Chun Chen, Guobing Xu","doi":"10.1186/s12957-025-03969-x","DOIUrl":"10.1186/s12957-025-03969-x","url":null,"abstract":"<p><strong>Background: </strong>With the popularity of LDCT screening, more and more small lung cancers have been found, and segmentectomy has been widely used because of its advantages in the treatment of early lung cancer, but the feasibility of segmentectomy is still controversial because of the increased complexity of the operation. Especially in complex lung segment surgery, it is more controversial. Preoperative three-dimensional reconstruction (3DR) is one of the effective methods to ensure the smooth operation, but its role in complex segmentectomy has not yet been verified. This article aims to evaluate the value of preoperative three-dimensional reconstruction in complex pulmonary segmentectomy by retrospective analysis of preoperative three-dimensional reconstruction assisted single-port video-assisted thoracoscopic complex pulmonary segmentectomy and comparison of surgical related indicators.</p><p><strong>Methods: </strong>The clinical data of patients with lung cancers who underwent single-port thoracoscopic complex segmentectomy (n = 299) from August 2015 to February 2019 were retrospectively analyzed, including 156 patients in the preoperative three-dimensional reconstruction group and 143 patients in the non-three-dimensional reconstruction group. Perioperative outcomes were compared between the two groups after comparative propensity score matching analysis (PSM) according to patient age, gender, BMI, lung function, smoking history, major tumor components, and tumor size.</p><p><strong>Results: </strong>There were 125 patients in each group after PSM, and the baseline characteristics of patients were comparable. There were no significant differences in age, sex, BMI, smoking history, tumor histology and tumor size between the two groups (all P > 0.05). Lymph node dissection (9.4 ± 5.1 vs. 10.6 ± 7.0), postoperative drainage volume (510.5 ± 279.4 ml vs. 528.7 ± 379.4 ml), indwelling time of chest tube (2.3 ± 1.1d vs. 2.5 ± 1.6 d), and the incidence of chronic air leaks (0.8% vs. 0.8%), total complications (2.4% vs. 5.6%), 30-day postoperative mortality (0% vs. 0%) were not statistically different between the two groups. The operative time of preoperative 3DR group (178.6 ± 50.5 min vs. 202.1 ± 51.4 min), intraoperative blood loss (47.6 ± 37.9 ml vs. 58.4 ± 36.2 ml) compared with the control group (non-3DR), the difference was statistically significant (P < 0.05).</p><p><strong>Conclusion: </strong>This is the first study to evaluate the usefulness of preoperative 3D reconstruction in complex segmentectomy. The results showed that the use of preoperative three-dimensional reconstruction for complex pulmonary segmentectomy was a safe and effective method, which could significantly reduce the operation time and blood loss.</p>","PeriodicalId":23856,"journal":{"name":"World Journal of Surgical Oncology","volume":"23 1","pages":"349"},"PeriodicalIF":2.5,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12482376/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145193301","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"A meta-analytic and systematic review to compare perioperative outcomes and prognosis between robotic and conventional (laparoscopic or open) liver resection in hepatocellular carcinoma cases.","authors":"Lingbo Hu, Xingpeng Shi, Aidong Wang, Fabiao Zhang","doi":"10.1186/s12957-025-03983-z","DOIUrl":"10.1186/s12957-025-03983-z","url":null,"abstract":"<p><strong>Background: </strong>Hepatectomy can be performed via laparoscopic liver resection (LLR), open liver resection (OLR), and robotic liver resection (RLR). However, the advantages of RLR over LLR and OLR with respect to the prognosis and perioperative outcomes of individuals with hepatocellular carcinoma (HCC) remain unclear. This study was designed to compare the perioperative and prognostic outcomes of RLR with those of LLR and OLR in patients with HCC.</p><p><strong>Methods: </strong>A comprehensive literature search was conducted in Embase, the Cochrane Library, PubMed, and Web of Science using the following keywords: \"liver resection,\" \"robotic,\" and \"hepatocellular carcinoma.\" The primary endpoints were overall survival (OS) and recurrence-free survival (RFS), with outcomes expressed as hazard ratios (HRs) and corresponding 95% confidence intervals (CIs). Secondary endpoints were perioperative outcomes, including resection margin status, intraoperative blood loss, transfusion requirement, operative time, conversion rate, postoperative complications, and length of hospital stay, reported as risk ratios (RRs) or mean differences (MDs) with 95% CIs.</p><p><strong>Results: </strong>Eighteen studies involving 4,098 patients were included. Twelve studies reported the long-term prognosis of patients, with six comparing RLR with LLR, four comparing RLR with OLR, and two comparing RLR with LLR and OLR. Sixteen studies reported perioperative outcomes. The meta-analysis illustrated that RLR was associated with improved RFS (HR 0.78, 95% CI 0.64-0.94; p = 0.0092) and OS (HR 0.72, 95% CI 0.56-0.92; p = 0.0101) compared with LLR. No significant differences in OS and RFS were observed between RLR and OLR. Compared with LLR, RLR was associated with a lower conversion rate to laparotomy (RR 0.50, 95% CI 0.31-0.79; p = 0.0034) and a longer operative time (MD 30.69 min, 95% CI 9.56-51.82; p = 0.0044). RLR also resulted in significantly lower rates of overall complications (RR 0.60, 95% CI 0.37-0.98; p = 0.0402), severe complications (RR 0.41, 95% CI 0.24-0.70; p = 0.0011, respectively), and a shorter hospital stay (MD - 3.70 days, 95% CI - 4.80 to - 2.61; p < 0.0001).</p><p><strong>Conclusion: </strong>In patients with HCC, RLR is associated with superior prognosis and perioperative outcomes compared with LLR and RLR exhibits better perioperative outcomes than OLR.</p>","PeriodicalId":23856,"journal":{"name":"World Journal of Surgical Oncology","volume":"23 1","pages":"348"},"PeriodicalIF":2.5,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12481867/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145193348","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}