World Journal of Surgical Oncology最新文献

{"title":"Knowledge, attitudes, and practices regarding chemotherapy-induced bone marrow suppression in ovarian cancer patients.","authors":"Xiaohang Liu, Jiashou Tao","doi":"10.1186/s12957-025-04018-3","DOIUrl":"10.1186/s12957-025-04018-3","url":null,"abstract":"<p><strong>Background: </strong>This study aimed to investigate the knowledge, attitudes, and practices (KAP) of ovarian cancer patients regarding chemotherapy-induced bone marrow suppression.</p><p><strong>Methods: </strong>This cross-sectional study was conducted on ovarian cancer patients at the Hospital between March and October 2024, using a self-designed questionnaire.</p><p><strong>Results: </strong>A total of 505 valid questionnaires were collected, with a 100% valid response rate. The average age of participants was 58.41 ± 6.64 years. The mean KAP and health literacy scores were 20.69 ± 6.24 (possible range: 0-18), 34.69 ± 4.97 (possible range: 10-50), 34.30 ± 7.07 (possible range: 9-45), and 8.18 ± 1.81 (possible range: 3-15), respectively. Pearson's correlation analysis showed positive interrelationships between KAP (r = 0.191, 0.315, P < 0.001), and negative correlations between KAP and health literacy (r=-0.326, -0.100, P < 0.05). Multivariate logistic analysis revealed positive associations of knowledge, attitude, education and cancer stage with practice (OR = 1.079, 4.369, P < 0.05), and negative associations between age and practice (OR = 0.905, 95%CI: 0.869-0.942, P < 0.001). In the adjusted SEM, education was directly associated with knowledge (Estimate = 3.63, P < 0.001). Direct associations were observed among KAP (Estimate = 0.238-0.311, P < 0.001), and between health literacy and knowledge (Estimate=-0.063, P < 0.001) or practice (Estimate=-1.050, P < 0.001).</p><p><strong>Conclusion: </strong>Ovarian cancer patients had sufficient knowledge, moderate attitude, positive practice and poor health literacy towards chemotherapy-induced bone marrow suppression. Educational and behavioral interventions are needed to promote better management of chemotherapy-induced bone marrow suppression.</p>","PeriodicalId":23856,"journal":{"name":"World Journal of Surgical Oncology","volume":"23 1","pages":"351"},"PeriodicalIF":2.5,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12482871/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145193358","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"SII and lung cancer in middle-aged and elderly population: the nonlinear connection and the mediating role of ABSI.","authors":"Bao Yao, Gan Xia, Liang Zhao, Kuan Ma, Zhuo Chen","doi":"10.1186/s12957-025-04005-8","DOIUrl":"10.1186/s12957-025-04005-8","url":null,"abstract":"","PeriodicalId":23856,"journal":{"name":"World Journal of Surgical Oncology","volume":"23 1","pages":"345"},"PeriodicalIF":2.5,"publicationDate":"2025-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12465597/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145178996","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"TERT promoter C250T mutation in a recurrent cervical chordoid meningioma: a unique case report.","authors":"Xuanbo Shao, Zhuofan Xu, Penghao Liu, Teng Zhang, Yang Feng, Shaxi Zhu, Zan Chen, Wanru Duan","doi":"10.1186/s12957-025-04003-w","DOIUrl":"10.1186/s12957-025-04003-w","url":null,"abstract":"<p><p>Chordoid meningioma (CM) is an uncommon histological variant of meningioma, typically found intracranially. Intraspinal occurrences, particularly in the cervical region, are exceedingly rare. We report a unique case of a 73-year-old male with cervical spinal CM who experienced tumor recurrence two years after gross total resection (GTR). Histopathological analysis confirmed the recurrence as anaplastic meningioma with telomerase reverse transcriptase (TERT) promoter C250T mutation, CNS WHO Grade 3-marking the first documented association of this mutation with spinal CM. This case underscores the diagnostic, molecular, and prognostic complexities of spinal CM and highlights the critical role of TERT promoter mutation in tumor behavior and classification.</p>","PeriodicalId":23856,"journal":{"name":"World Journal of Surgical Oncology","volume":"23 1","pages":"344"},"PeriodicalIF":2.5,"publicationDate":"2025-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12466048/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145179014","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predictive value of combined Albumin-Globulin score and psoas muscle index for postoperative prognosis in combined hepatocellular carcinoma and cholangiocarcinoma.","authors":"Zeyuan Qiang, Zheng Zhang, Chuang Jiang, Haichuan Wang","doi":"10.1186/s12957-025-04000-z","DOIUrl":"10.1186/s12957-025-04000-z","url":null,"abstract":"<p><strong>Background: </strong>Nutrition and inflammation play vital roles in the prognosis of cancer patients. This study evaluated the impact of relevant indicators-albumin-globulin score (AGS), psoas muscle index (PMI), and the combination of AGS and PMI (CAP)- on postoperative outcomes in combined hepatocellular carcinoma and cholangiocarcinoma (cHCC-CC) patients.</p><p><strong>Methods: </strong>One hundred forty one cHCC-CC patients treated surgically from 2010 to 2020 were retrospectively analyzed. Psoas muscle area was measured via abdominal CT scans. Albumin (ALB), globulin (GLB), and PMI cutoff values were established through receiver operating characteristic (ROC) curves. The influence of AGS, PMI, and CAP on cHCC-CC prognosis was evaluated using Time-dependent ROC curves. The predictive accuracy of nomograms were evaluated using calibration plots, the C-index value, and the area under the ROC curves (AUC).</p><p><strong>Results: </strong>Lower PMI and higher AGS indicated poorer OS and DFS. A lower CAP grade was linked to a more favorable prognosis, with CAP grade 1 showing the best and grade 3 the worst prognosis. The Td-ROC curve demonstrates that CAP grade outperforms PMI and AGS in terms of predictive ability at various time points. The predictive accuracy of nomograms was considered acceptable, with c-index values of 0.684 (95% CI: 0.632-0.731) and 0.684 (95% CI: 0.635-0.734) for OS and DFS, respectively.The corresponding AUC values for 1, 3, and 5-year OS were 0.731, 0.744, and 0.720, and for DFS were 0.768, 0.796, and 0.757.</p><p><strong>Conclusions: </strong>The CAP grade, integrating AGS and PMI, significantly correlates with postoperative prognosis in cHCC-CC patients. It stands as a crucial indicator for optimizing treatment planning.</p>","PeriodicalId":23856,"journal":{"name":"World Journal of Surgical Oncology","volume":"23 1","pages":"342"},"PeriodicalIF":2.5,"publicationDate":"2025-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12465814/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145178993","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Survey on and analysis of the factors influencing the postoperative sleep quality of Chinese patients with oesophageal cancer.","authors":"Xi-Xi Yin, Xiao Yu, Yanyan Fang, Dandan Liu, Liping Yang, Li Liu, Yanhui Pan","doi":"10.1186/s12957-025-04008-5","DOIUrl":"10.1186/s12957-025-04008-5","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Background: &lt;/strong&gt;Sleep quality problems are common in patients with cancer, and the likelihood of sleep disorders is high in postoperative patients. Patients with oesophageal cancer are prone to postoperative problems with sleep quality owing to the complexity of the surgery. Therefore, we aimed to understand sleep quality of patients after oesophageal cancer surgery, analyse the factors that influence sleep quality, and provide theoretical references to improve the sleep quality of patients after oesophageal cancer surgery.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;A self-designed general information questionnaire, the Pittsburgh Sleep Quality Index (PSQI) and the Hospital Anxiety and Depression Scale were used to conduct a questionnaire survey. This questionnaire was used to survey 119 patients who underwent oesophageal cancer surgery at our hospital's thoracic department from October 2020 to June 2021. Statistical methods such as Spearman correlation analysis and multiple regression analysis were used to analyse the sleep quality of the patients and explore the factors that influenced sleep quality.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;(1) Among the 119 postoperative oesophageal cancer patients included in the study, 116 patients (97.48%) experienced sleep disturbance (PSQI≥7). The mean PSQI scores were 15.19±3.95; 60.5% (72/119) of patients experienced anxiety, and 48.74% (58/119) experienced depression. (2) Spearman correlation analysis revealed that patients' sleep quality scores negatively correlated with level of education and surgical approach (correlation coefficients of -0.23 and -0.27, respectively, P&lt;0.05) and positively correlated with pain scores and nutritional risk (correlation coefficients of 0.26 and 0.17, respectively, P&lt;0.05). The results revealed no correlation between anxiety or depression scores and PSQI scores. The average monthly household income was correlated with level of education, home residence, a burden of medical expenses, postoperative complications, and anxiety scores (correlation coefficients were 0.17, -0.28, -0.47, 0.26, and-0.24, respectively; P&lt;0.05). The burden of medical expenses was also correlated with level of education and home residence (the correlation coefficients were -0.16 and 0.22, respectively; P&lt;0.05). Postoperative complications were positively correlated with anxiety scores and depression scores (correlation coefficients were 0.34 and 0.27, respectively, P&lt;0.05). (3) Multiple regression analysis revealed that surgical approach, pain scores, level of education, and nutritional risk scores affect the sleep quality of patients (95% CI=9.83-17.48, adjusted R&lt;sup&gt;2&lt;/sup&gt;=0.23, P&lt;0.05).&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusions: &lt;/strong&gt;The postoperative sleep quality of Chinese oesophageal cancer patients was generally poor, which was related to the surgical approach, education level, pain score, and nutritional risk score. Anxiety, depression scores, and average monthly household income may also indirectly af","PeriodicalId":23856,"journal":{"name":"World Journal of Surgical Oncology","volume":"23 1","pages":"343"},"PeriodicalIF":2.5,"publicationDate":"2025-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12465165/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145179057","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical application of Grunenwald incision in cervicothoracic junction surgery.","authors":"Yanzhao Xu, Junhao Qi, Yuefeng Zhang, Shiwang Wen, Zhenhua Li, Mingbo Wang, Peng Su, Chao Huang, Fan Zhang, Ziqiang Tian","doi":"10.1186/s12957-025-03987-9","DOIUrl":"10.1186/s12957-025-03987-9","url":null,"abstract":"<p><strong>Background: </strong>To evaluate the clinical efficacy of Grunenwald incision in cervicothoracic junction surgery.</p><p><strong>Methods: </strong>A retrospective analysis was performed on 29 patients treated at the Fourth Hospital of Hebei Medical University, including 28 patients with cervicothoracic junction tumors (11cases of upper mediastinal tumors, 7 cases of superior sulcus tumors, 4 cases of thyroid tumors with upper mediastinal invasion, 4 cases of chest wall tumors, 2 cases of esophageal cancers with supraclavicular lymph node metastasis) and 1 patient with cervicothoracic junction penetrating trauma. Grunenwald incision or additional posterolateral thoracic incision, median sternal incision or neck collar incision were used in all patients.</p><p><strong>Results: </strong>There was no perioperative death in the whole group. Complete tumor resection was achieved in 25 cases; palliative resection was performed in three cases, and one case underwent complete foreign body removal. The operation time ranged from 120 to 430 minutes, with an average of (231.90 ± 85.30) minutes. The intraoperative blood loss was between 100 and 1000 milliliters, with an average of (286.56 ± 192.90) milliliters. The postoperative hospital stay lasted 6 to 28 days, with an average of (13.14 ± 5.12) days. Follow-up periods spanned 6 to 142 months, with an average of (66.66 ± 46.96) months. During the follow-up period, six patients died.</p><p><strong>Conclusions: </strong>Grunenwald incision can provide good exposure of the structures near the cervicothoracic junction, preserve the integrity of the sternoclavicular joint, reduce shoulder deformity, and has advantages for patients with cervicothoracic junction tumor, high rib resection, and cervicothoracic junction trauma.</p>","PeriodicalId":23856,"journal":{"name":"World Journal of Surgical Oncology","volume":"23 1","pages":"346"},"PeriodicalIF":2.5,"publicationDate":"2025-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12465367/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145178974","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Short- and medium-term impacts of unplanned intraoperative conversion during laparoscopic liver resection for hepatocellular carcinoma patients: a propensity score-matched study.","authors":"Liang Wang, Yufu Peng, Lian Li, Liangliang Xu, Mingqing Xu, Bo Li, Yonggang Wei, Ming Zhang","doi":"10.1186/s12957-025-03984-y","DOIUrl":"10.1186/s12957-025-03984-y","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Background & aims: &lt;/strong&gt;Although laparoscopic liver resection (LLR) has been widely accepted and considered a safe alternative to open liver resection in patients with hepatocellular carcinoma (HCC), it is still inevitable that some patients will encounter difficulties during LLR and need to be converted to open liver resection (OLR). It is currently uncertain whether unplanned intraoperative conversion to open liver resection (UCOLR) during LLR in HCC patients has a negative impact on patient prognosis, and there are still no comparative studies between HCC patients who underwent successful LLR and those who underwent UCOLR. Therefore, the aim of this study was to compare the short- and medium-term outcomes of LLR and UCOLR for HCC between two matched groups.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;We retrospectively studied patients with HCC who underwent LLR or UCOLR between November 2016 and November 2022 at West China Hospital, Sichuan University. After 1:4 propensity score matching (PSM) was performed to reduce selection bias, the short-term and medium-term oncological outcomes of LLR and UCOLR were compared.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;Out of 846 patients included in this study (806 in the LLR group and 40 in the UCOLR group), 150 patients in the LLR group and 40 patients in the UCOLR group were selected for further comparison after 1:4 PSM. Compared to those who underwent successful LLR, patients who experienced UCOLR during LLR had significantly more intraoperative bleeding (500 ml vs. 200 ml, p &lt; 0.001), required more blood transfusions (p &lt; 0.001), had higher transfusion rates (47.5% vs. 6.0%, p &lt; 0.001), and experienced longer operative times (244 min vs. 210 min, p = 0.042). Additionally, the overall complication rate was significantly greater in the UCOLR group than in the LLR group (45.0% vs. 20.7%, p = 0.002). Further analysis revealed that patients in the UCOLR group had a significantly greater risk of pulmonary infections (37.5% vs. 15.3%, p = 0.002), pleural effusion (27.5% vs. 7.3%, p &lt; 0.001), anemia (22.5% vs. 4.7%, p &lt; 0.001), and bile leakage (10.0% vs. 2.0%, p = 0.017). Moreover, those who experienced conversion to UCOLR reported significantly more postoperative pain (62.5% vs. 7.3%, p &lt; 0.001) and longer hospital stays (6 days vs. 5 days, p = 0.005). In terms of quality of life (QOL) assessment, the LLR group showed a trend toward better general health at 1 and 3 months after surgery. However, no significant differences were detected between the LLR and UCOLR groups in terms of 3-year disease-free survival (76.4% for LLR vs. 63.5% for UCOLR, p = 0.075) or overall survival (82.2% for LLR vs. 71.7% for UCOLR, p = 0.124).&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusion: &lt;/strong&gt;Compared to patients who underwent successful LLR, patients in the UCOLR group experienced worse short-term outcomes, although medium-term survival outcomes at 3 years were comparable. Additionally, segment 7 or 8 lesions with high AFP have a greater chance of ","PeriodicalId":23856,"journal":{"name":"World Journal of Surgical Oncology","volume":"23 1","pages":"340"},"PeriodicalIF":2.5,"publicationDate":"2025-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12465619/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145151147","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"\"Ewing's sarcoma of the duodenum: a rare gastrointestinal presentation\": case report and review of literature.","authors":"Sujata Agrawal, Paramita Paul","doi":"10.1186/s12957-025-03986-w","DOIUrl":"10.1186/s12957-025-03986-w","url":null,"abstract":"<p><p>Ewing's sarcoma (ES) is exceptionally rare in the gastrointestinal tract, with only a few cases documented in the literature. We present a case of duodenal Ewing's sarcoma in a 44-year-old woman. The patient presented with severe abdominal pain, vomiting, and loss of appetite. Upper gastrointestinal endoscopy revealed a huge bulge in the first part of the duodenum (D1) wall, resulting in luminal narrowing in D1 and D2. A contrast-enhanced computed tomography scan corroborated the findings with no evidence of any distal metastasis. The patient is a known hypothyroid and had undergone hysterectomy five years back and cholecystectomy one year back. The patient underwent a Whipple procedure along with lymph node dissection. During surgery, a 4.5 cm mass was discovered in the D1 extending to the D2 segment of the duodenum. Histological examination showed a small round cell tumor in the submucosal region. The morphological differentials considered were gastrointestinal stromal tumor (GIST), poorly differentiated carcinoma, ES, neuroendocrine carcinoma (NEC) and lymphoma. Immunohistochemically the tumor cells tested positive for vimentin, NKX2.2, and CD99 (MIC2), and negative for markers of epithelial malignancy (AE1/AE3), lymphoma (CD45), melanoma (HMB45), NEC (INMS1,synaptophysin, chromogranin) and GIST (c-kit). One of the peri-duodenal lymph nodes showed a metastatic deposit. The case was diagnosed as Ewing's sarcoma (extra skeletal), TNM stage pT1 pN1. It was further ratified through fluorescence in situ hybridization (FISH), which showed a EWSR1 (22q12.1) gene rearrangement. A post-surgery PET scan indicated no residual disease. The patient had been receiving post-surgical adjuvant therapy and has completed four cycles of VAC (vincristine dactinomycin cyclophosphamide) and two cycles of VIME (Vincristine, Ifosfamide, Mesna, and Etoposide). The patient is disease-free with one-year follow-up. Follow up with PET scan is being performed at 3 months interval for the first year. The prognosis for Ewing's sarcoma in the gastrointestinal tract is not well-documented; however, a recent review of cases involving the small intestine suggests a poor prognosis. A follow up PET scanning every three months initially would help to target early recurrences and the interval can be increased after 2 years. Also emerging techniques like liquid biopsies is becoming increasingly relevant for detection of recurrences and metastasis.</p>","PeriodicalId":23856,"journal":{"name":"World Journal of Surgical Oncology","volume":"23 1","pages":"341"},"PeriodicalIF":2.5,"publicationDate":"2025-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12465797/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145151193","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A rare incidence of pseudoangiomatous stromal hyperplasia (PASH) in a senior adult male: a case report highlighting a novel presentation.","authors":"Gabriel Baccam Unkrich, Jennifer L Somerville, Vincent J Reid","doi":"10.1186/s12957-025-03777-3","DOIUrl":"10.1186/s12957-025-03777-3","url":null,"abstract":"<p><strong>Background: </strong>Pseudoangiomatous stromal hyperplasia (PASH) is a rare benign mesenchymal lesion of the breast that is most commonly seen in young premenopausal and perimenopausal females and found in approximately 23% of breast specimens. In rare cases, PASH has been reported exclusively in young adult males and is associated with gynecomastia. The prevalence of benign breast masses in men with gynecomastia ranges from approximately 23.8-47.4% and peaks between the ages of 50 and 80. PASH frequently presents as a palpable mass or is incidentally identified through imaging and microscopy. Due to its varied and infrequent presentations, PASH is often mistaken for malignancy or other breast lesions, particularly in senior adult males (over 65 years old), an age group commonly affected by benign breast masses and male breast cancer. Given its rare and diverse presentation, it is crucial to consider PASH in the differential diagnosis of a male patient with a benign breast tumor to guide appropriate management, avoid overtreatment, and ensure prompt evaluation for any underlying abnormalities.</p><p><strong>Case presentation: </strong>This report presents a unique case of PASH in a senior adult male, aged over 65 years, who presented with an enlarging palpable areolar mass. Notably, the patient had no family history or past medical history of breast cancer. Imaging studies, including mammography and ultrasound, revealed mild gynecomastia and BIRADS-4 classification, prompting further investigation. A core needle biopsy confirmed the diagnosis of PASH, showing no evidence of carcinoma or malignancy. Given the mass's progressive enlargement, surgical excision was recommended and successfully performed.</p><p><strong>Conclusions: </strong>This report outlines the patient's clinical presentation, diagnostic evaluation, and management while also providing a brief review of the limited literature. It is the first report to describe the presentation and management of PASH in a male over 65 years old with no history of abnormal breast pathology. Understanding atypical cases of PASH is essential for accurate diagnosis and appropriate management in this patient demographic.</p>","PeriodicalId":23856,"journal":{"name":"World Journal of Surgical Oncology","volume":"23 1","pages":"339"},"PeriodicalIF":2.5,"publicationDate":"2025-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12465646/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145151217","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Real-world risk factors for incomplete cytoreduction in peritoneal carcinomatosis patients scheduled for cytoreductive surgery and hyperthermic intraperitoneal chemotherapy.","authors":"Chao-Yu Chen, Li-Wen Lee, Tzu-Hao Huang, Yu-Che Ou, Chien-Hui Hung, Jrhau Lung, Yu-San Liao, Ting-Yao Wang, Lan-Yan Yang","doi":"10.1186/s12957-025-03988-8","DOIUrl":"10.1186/s12957-025-03988-8","url":null,"abstract":"<p><strong>Background: </strong>Cytoreductive surgery (CRS) with hyperthermic intraperitoneal chemotherapy (HIPEC) is a treatment option for selected patients with peritoneal carcinomatosis. This study investigates preoperative factors influencing incomplete CRS.</p><p><strong>Methods: </strong>We retrospectively reviewed 188 patients scheduled for curative-intent CRS/HIPEC between April 2015 and May 2023. Preoperative peritoneal cancer index (PCI) scores were determined using computed tomography (CT) (n = 155) and/or magnetic resonance imaging (MRI) (n = 82).</p><p><strong>Results: </strong>Complete CRS was achieved in 126 patients (67.0%) and incomplete CRS in 62 (32.9%). Colorectal cancer was the predominant primary tumor (complete CRS: 42.9%; incomplete CRS: 50.0%), followed by ovarian cancer (34.1% vs. 17.7%). Multivariate analysis revealed imaging-specific risk factors: the CT model identified ascites (OR = 4.57) and higher PCI scores in regions 0 and 11, while the MRI model identified prior chemotherapy (OR = 101.06) and higher PCI scores in regions 2, 3, and 11. Decision tree analysis showed ascites altered PCI thresholds for patients with ascites (CT: 18.5, MRI: 6.5) versus without (CT: 8.5, MRI: 12.5). Both imaging modalities demonstrated moderate agreement with surgical findings for total PCI scores (ICC = 0.656 and 0.678), with stronger correlations in regions 0-8 than regions 9-12. Small bowel regions showed poor accuracy, with lowest sensitivity in region 11.</p><p><strong>Conclusions: </strong>Ascites and higher PCI scores in specific regions identified on preoperative imaging were associated with increased risk of incomplete CRS. These findings can improve patient selection and preoperative planning for CRS/HIPEC in peritoneal carcinomatosis.</p>","PeriodicalId":23856,"journal":{"name":"World Journal of Surgical Oncology","volume":"23 1","pages":"337"},"PeriodicalIF":2.5,"publicationDate":"2025-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12462296/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145138723","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}