World Journal of Surgical Oncology最新文献

{"title":"Progressive elevation of MnSOD and GPX4 expression across the spectrum of pulmonary adenocarcinoma lesions: a digital pathology study.","authors":"Hui-Ting Lee, Chao-Yu Liu, Chia-I Lin, Yung-Hui Li, Wan-Chun Li, Shin-Ting Yeh, Hui-Chen Lin, Chen-Sung Lin","doi":"10.1186/s12957-026-04457-6","DOIUrl":"10.1186/s12957-026-04457-6","url":null,"abstract":"<p><strong>Background: </strong>Manganese superoxide dismutase (MnSOD) and glutathione peroxidase 4 (GPX4) are key components of the mitochondrial redox defense system; however, their clinical associations across lung adenocarcinoma spectrum lesions (ASLs) are insufficiently defined.</p><p><strong>Methods: </strong>We analyzed 67 resected ASLs, comprising 14 preinvasive lesions and 53 invasive adenocarcinomas, from 61 patients who underwent video-assisted thoracoscopic surgery (VATS). Paired nonneoplastic lung tissue adjacent to preinvasive lesions served as normal controls. MnSOD and GPX4 expression levels were assessed through immunohistochemical (IHC) staining, digitized to generate whole slide images (WSIs), and semiquantified using IHC pixelwise H-score (0-300) by employing an ImageJ plugin. The exploratory association of MnSOD and GPX4 expression with clinicopathological variables and overall survival was evaluated.</p><p><strong>Results: </strong>MnSOD and GPX4 IHC pixelwise H-scores increased stepwise from normal lung tissue to preinvasive lesion and further to invasive adenocarcinoma in parallel with higher T-status category. Exploratory analyses demonstrated that a high MnSOD IHC pixelwise H-score (> 154.5) was associated with higher serum carcinoembryonic antigen (CEA) levels (p = 0.001), higher maximum standardized uptake value (SUVmax) on positron emission tomography (p = 0.041), larger tumor size (p = 0.002), M1 status (p = 0.076), spread through air spaces (STAS, p = 0.036), and pleural invasion (p = 0.019). By contrast, a high GPX4 IHC pixelwise H-score (> 165.9) was associated only with pleural invasion (p = 0.014). An exploratory nonlinear inverse association was observed between MnSOD IHC pixelwise H-scores and serum CEA levels (p = 0.004), with a steeper increase at lower CEA levels and a plateau at approximately 5 ng/mL. A high MnSOD IHC pixelwise H-score (> 154.5) exhibited a borderline association with shorter survival (p = 0.052). M status (p = 0.008) and STAS (p = 0.012) were associated with an increased risk of death in exploratory multivariate analysis.</p><p><strong>Conclusions: </strong>In this hypothesis-generating study, MnSOD and GPX4 IHC pixelwise H-scores progressively increase across lung ASLs, and MnSOD is associated with clinicopathological features of tumor aggressiveness. IHC pixelwise H-score analysis may be a feasible semiquantitative approach for evaluating protein expression in lung ASLs.</p>","PeriodicalId":23856,"journal":{"name":"World Journal of Surgical Oncology","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2026-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13647588/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148449609","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A nomogram for predicting 3-month mortality in colorectal cancer patients requiring perioperative ICU admission: a retrospective cohort study.","authors":"Chengcheng Dong, Daiyin Cao, Xiaofei Zhang, Qianxin Luo","doi":"10.1186/s12957-026-04495-0","DOIUrl":"10.1186/s12957-026-04495-0","url":null,"abstract":"<p><strong>Background: </strong>Colorectal cancer patients requiring perioperative intensive care unit (ICU) admission represent a high-risk subgroup with substantial short-term mortality. This study aimed to develop and internally validate a nomogram for estimating 3-month all-cause mortality in colorectal cancer patients requiring perioperative ICU care.</p><p><strong>Methods: </strong>This single-center retrospective cohort study screened patients hospitalized for colorectal cancer surgery between January 2014 and December 2018. The final cohort included 415 patients requiring perioperative ICU admission. The primary endpoint was all-cause mortality within 3 months after ICU admission. The intended prediction time point was the end of the first 24 h after ICU admission. Candidate predictors were obtained from the preoperative period, the index surgery, and the first 24 h after ICU admission. Multivariable logistic regression was used to identify independent predictors and construct the nomogram. Model performance was evaluated using receiver operating characteristic curve analysis, bootstrap internal validation, calibration analysis, and decision curve analysis.</p><p><strong>Results: </strong>Among 415 included patients, 58 (14.0%) died within 3 months after ICU admission. The final nomogram incorporated preoperative albumin, APACHE II score, CRRT within the first 24 h after ICU admission, mechanical ventilation within the first 24 h after ICU admission, and laparoscopic surgery. Higher albumin level and laparoscopic surgery were associated with lower mortality risk, whereas higher APACHE II score, CRRT, and mechanical ventilation were associated with increased mortality risk. The nomogram showed good discrimination, with an AUC of 0.882 (95% CI, 0.829-0.927) and bootstrap internal validation yielded an optimism-corrected C-index of 0.872. Calibration analysis showed good agreement between predicted and observed risk, and decision curve analysis suggested potential clinical utility across clinically relevant threshold probabilities. The nomogram showed better discrimination than APACHE II alone.</p><p><strong>Conclusions: </strong>We developed and internally validated a nomogram for estimating 3-month mortality at the end of the first 24 h after ICU admission in colorectal cancer patients requiring perioperative ICU care. The model may support early risk stratification in this high-risk population, but external validation is required before routine clinical implementation.</p>","PeriodicalId":23856,"journal":{"name":"World Journal of Surgical Oncology","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2026-07-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13563813/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148437753","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A multidisciplinary virtual (p)rehabilitation model of care for colorectal cancer surgery.","authors":"Vitor de Oliveira Campos E Silva, Jack Reeves, Guilherme Domingues Ferreira, Kate Alexander, Sascha Karunaratne, Michael Solomon, Cherry Koh, Aveline Chan, Deshitha Hewawasam Thuduwage, Anthonette Angmark, Cheryl Tobler, Kimberley Bostock, Kaylene Pring, Lilian Whitehead, Betty Stampoulis-Lyttle, Jessica Connell, Se Won Jeon, Madeleine Turton, Eleanor Bills, Jesse Gates, Jacqueline Black, Tara Dehm, Rebekah Dempsey, Linda Denehy, Bernhard Reidel, Daniel Steffens","doi":"10.1186/s12957-026-04493-2","DOIUrl":"10.1186/s12957-026-04493-2","url":null,"abstract":"<p><strong>Background: </strong>Colorectal cancer is a leading cause of cancer-related morbidity and mortality globally, with surgery the primary curative treatment. Despite advances in medical care, postoperative complications are common, resulting in prolonged hospital stays, delayed recovery, diminished quality of life, and increased healthcare costs. This study aimed to develop a standardised, evidence-based, multidisciplinary virtual model of care for (p)rehabilitation (i.e., preoperative and postoperative rehabilitation) in colorectal cancer surgery patients.</p><p><strong>Methods: </strong>This study reports the development of a multidisciplinary virtual prehabilitation model of care for the PRIORITY-CONNECT 2 randomised controlled trial. A collaborative framework was developed between Royal Prince Alfred Hospital (Sydney) and Peter MacCallum Cancer Centre (Melbourne), two major Australian colorectal cancer treatment centres with extensive prehabilitation expertise. Five discipline-specific working groups were established to guide development of domains within the model of care, namely, nutrition counselling, peer support groups, psychology, physiotherapy and nursing. Each working group was comprised of discipline experts, colorectal surgeons, anaesthetists, and academic researchers, chaired by a senior discipline leader. Working groups convened virtually via Microsoft Teams between November 2024 and March 2025, meeting up to five times per discipline to achieve consensus on the final model of care. The approach integrated current literature, clinical expertise, and consumer perspectives to develop individualised care pathways spanning 1-6 weeks preoperatively through 12 months postoperatively.</p><p><strong>Results: </strong>Five comprehensive discipline-specific virtual models of care were developed, delineating specific roles, interventions, timelines, and outcome measures aligned with the overall (p)rehabilitation framework. As a result, each specialty developed a comprehensive, evidence-based approach to manage patients with colorectal cancer undergoing surgery. The models of care are tailored based on initial preoperative assessment made by specialists and involve different pathways of care depending on patient needs. After surgery, all patients are reassessed by specialists and further management is tailored based upon the judgement of the clinician, patient preferences, and reported symptoms.</p><p><strong>Conclusion: </strong>This multidisciplinary, evidence-based model of care provides comprehensive guidance for implementing virtual (p)rehabilitation in people undergoing colorectal cancer surgery. By standardising care pathways across five key disciplines, while maintaining individualised approaches, this framework addresses critical gaps in clinical practice and provides a foundation for implementation and evaluation of (p)rehabilitation programs.</p>","PeriodicalId":23856,"journal":{"name":"World Journal of Surgical Oncology","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2026-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13640072/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148424795","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"MRI characteristics of appendicular soft tissue lymphoma: a retrospective analysis.","authors":"Valentin Weisse, Sebastian Weiss, Peter Bannas, Alexander Korthaus, Alonja Reiter, Thore Raschka, Andreas Lübke, Carsten Schlickewei, Alexander Spiro, Jana Käthe Striefler, Karl-Heinz Frosch, Matthias Priemel","doi":"10.1186/s12957-026-04478-1","DOIUrl":"10.1186/s12957-026-04478-1","url":null,"abstract":"<p><strong>Objectives: </strong>Appendicular soft tissue lymphoma (ASTL) are rare and frequently misinterpreted as soft tissue sarcoma. This can put patients at risk. Existing studies evaluating MRI of ASTL are sparse, small scaled and report heterogenous results. The purpose of this study was therefore, to identify comprehensive MRI characteristics of ASTL.</p><p><strong>Material & methods: </strong>We retrospectively analyzed demographic data, clinical presentation and MRI data of 26 patients presenting to our musculoskeletal tumor surgery center between 2011 and 2023 with histopathologically proven ASTL.</p><p><strong>Results: </strong>Identified MRI characteristics included a diameter larger than 5 cm (77%), hyperintense signal intensity in all T2-weighted, PD-weighted and short tau inversion recovery (STIR) sequences and iso- to slightly hyperintense signal intensity in T1-weighted sequences compared to skeletal muscle. Furthermore, irregular contrast enhancement of adjacent fasciae (60%) and predominant enhancement of peripheral tumor accompanied by slightly less intensive homogenous enhancement of the remaining tumor (55%) were observed. Additionally, regional lymphadenopathy (31%), subcutaneous stranding (58%), traversing vessels (88%) and the absence of encapsulation (100%) were discernable. Features seen in ASTL primarily involving muscle (n = 16), were involvement of multiple muscles (100%), tissue types (88%) and anatomical compartments (69%) as well as long segmental involvement (69%), growth along neurovascular bundles (56%) and partial or complete encasement of major vessels (81%). Intratumoral necrosis was identified in four cases (25%).</p><p><strong>Conclusion: </strong>MRI provides the presented morphological indicators, that should raise suspicion of ASTL. Our findings suggest that necrosis may occasionally occur in pretreatment ASTL and its presence alone should not exclude lymphoma from the differential diagnosis.</p>","PeriodicalId":23856,"journal":{"name":"World Journal of Surgical Oncology","volume":"24 1","pages":""},"PeriodicalIF":2.8,"publicationDate":"2026-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13349004/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148424731","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A quasi-bridge to surgery approach for stage IV obstructive colon cancer: extending the bridge-to-surgery concept to metastatic disease.","authors":"Shu-Huan Huang, Sum-Fu Chiang, Kun-Yu Tsai, Pao-Shiu Hsieh, Jeng-Fu You, Cheng-Chou Lai","doi":"10.1186/s12957-026-04492-3","DOIUrl":"10.1186/s12957-026-04492-3","url":null,"abstract":"<p><strong>Background: </strong>The optimal management of stage IV colorectal cancer with malignant large bowel obstruction remains controversial. Self-expandable metallic stents are an established bridge to surgery in non-metastatic disease, but the role of primary tumor resection after stent placement in stage IV patients is unresolved. We propose and evaluate a \"quasi-bridge to surgery\" (Quasi-BTS) strategy in which stenting serves as a biological selection tool to identify patients who may benefit from delayed primary tumor resection.</p><p><strong>Methods: </strong>This single-center retrospective cohort study analyzed consecutive stage IV obstructive colorectal cancer patients who underwent successful self-expandable metallic stent placement between January 2007 and December 2023. Patients were categorized into a Quasi-BTS group (delayed primary tumor resection), a palliative chemotherapy-only group, and palliative care-only group. Primary outcomes were overall survival, stent-related complications, and stoma-free survival.</p><p><strong>Results: </strong>Fifty-three patients were analyzed (Quasi-BTS, n = 16; palliative chemotherapy only, n = 22; palliative care only, n = 15). The Quasi-BTS group had zero overall stent-related complications versus 46.7% and 36.4% in the palliative care-only and palliative chemotherapy-only groups, respectively (P = 0.009); perforation alone was a non-significant trend (0% vs. 26.7% vs. 27.3%, P = 0.070). The laparoscopic surgery rate was 82%, the primary anastomosis rate was 92%, and bevacizumab was safely administered in all 6 patients who received it. Overall survival was significantly longer in the Quasi-BTS group than in either palliative group (log-rank all P < 0.001). After multivariable Cox adjustment for age, ASA, metastatic site, and targeted-therapy use, the Quasi-BTS group retained a markedly reduced hazard of death (adjusted HR 0.037, 95% CI 0.010-0.135). The mean interval from stent insertion to resection was 21.2 days in the resection-first subgroup.</p><p><strong>Conclusions: </strong>The Quasi-BTS strategy may extend the bridge-to-surgery concept to metastatic colorectal cancer by repurposing stenting as a bridge for patient selection. Performing primary tumor resection within approximately three months of stent insertion was associated with the absence of stent-related complications in our cohort, appears to permit the subsequent use of anti-angiogenic targeted therapy without observed stent-related complications, and was associated with improved long-term survival.</p>","PeriodicalId":23856,"journal":{"name":"World Journal of Surgical Oncology","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2026-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13422036/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148424752","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"CDK4/6 inhibitor combined with endocrine therapy: a real-world evaluation of efficacy and safety in HR+/HER2- advanced breast cancer.","authors":"Rui Wang, Yuying Wang, Yaling Zeng, Xihui Tu, Di Lu, Purong Zhang","doi":"10.1186/s12957-026-04486-1","DOIUrl":"10.1186/s12957-026-04486-1","url":null,"abstract":"<p><strong>Background: </strong>The combination of cyclin-dependent kinase 4/6 inhibitor (CDK4/6i) with endocrine therapy (ET) constitutes the standard treatment for Hormone receptor-positive (HR+)/Human epidermal growth factor receptor 2-negative (HER2-) advanced breast cancer (ABC). It is essential to evaluate the efficacy and safety profiles of CDK4/6i in Chinese patients with HR+/HER2- ABC, in order to provide a theoretical foundation for developing precision-based therapeutic strategies.</p><p><strong>Methods: </strong>Clinical data of patients with ABC treated with CDK4/6i combined with ET between April 2021 and April 2024 at the Department of Breast Oncology, Sichuan Cancer Hospital, were retrospectively collected. Clinicopathological characteristics and prognostic outcomes were analyzed to evaluate the efficacy and safety of CDK4/6i-based regimens, and then we explored factors associated with progression-free survival (PFS). The secondary endpoints incorporate overall survival (OS), objective response rate (ORR) and clinical benefit rate (CBR).</p><p><strong>Results: </strong>A total of 124 patients were enrolled, with a median follow-up period of 23.0 months. The median PFS (mPFS) was 20.0 months, while the median OS (mOS) was not reached. Patients without measurable target lesions were excluded, and a total of 90 patients were included for further analysis. The ORR was 46.7% (42/90), and the CBR was 53.3% (48/90). Cox multivariate regression analysis identified Ki-67<20%, Age-adjusted Charlson Comorbidity Index (aCCI)<10, line of CDK4/6i ≤ 2, and sensitivity or acquired resistance to ET as independent predictors of PFS. Leukopenia (83.1%) was the most common adverse event (AE), with 75.8% of these cases classified as grade 1-2.</p><p><strong>Conclusion: </strong>This real-world (RWD) study in China has further confirmed the efficacy and safety in HR+/HER2- ABC. These findings provide further evidence for clinically identifying optimal patient population likely to derive superior benefits from CDK4/6i combination regimens.</p>","PeriodicalId":23856,"journal":{"name":"World Journal of Surgical Oncology","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2026-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13632389/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148424749","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cadherin-mediated cell adhesion networks drive tumor growth and therapeutic responses in head and neck cancer.","authors":"Mostafa A Abdel-Maksoud, Abdulaziz Alamri, Aljawharah Fahad, Salman Alrokayan, Mohammed Aufy, Bushra Hafeez Kiani, Hanyong Zhang, Muhammad Mazhar Ayaz, Yasir Hameed, Saeedah Almutairi","doi":"10.1186/s12957-026-04427-y","DOIUrl":"10.1186/s12957-026-04427-y","url":null,"abstract":"<p><strong>Background: </strong>Cadherin family genes (CDH1, CDH2, and CDH3) regulate cell-cell adhesion and epithelial integrity and have emerging roles in tumorigenesis. However, their molecular and functional relevance in Head and Neck Squamous Cell Carcinoma (HNSC) remains incompletely defined.</p><p><strong>Methods: </strong>Cadherin expression was evaluated in HNSC and normal oral epithelial cell lines using RT-qPCR. Multi-omics analyses of transcriptomic, methylation, mutation, and copy number variation (CNV) data were performed using TCGA datasets through GSCA, OncoDB, cBioPortal, and UALCAN. Prognostic significance was assessed using Kaplan-Meier and meta-analysis approaches. miRNA-mRNA interactions were predicted using miRNet and validated experimentally. Immune associations, drug sensitivity, and protein-protein interactions were explored using TISIDB, GSCA, STRING, and DAVID. Functional effects of CDH1 and CDH2 were evaluated by siRNA knockdown in FaDu and SCC9 cells, followed by proliferation, colony formation, wound healing, and xenograft assays.</p><p><strong>Results: </strong>CDH1, CDH2, and CDH3 were significantly upregulated in HNSC cell lines and TCGA tumor samples, with CDH3 showing the highest diagnostic accuracy (AUC = 0.90). Hypomethylation and CNV amplification contributed to cadherin dysregulation, particularly for CDH2 and CDH3. Elevated cadherin expression correlated with poor overall survival. miR-200a-3p and miR-200c-3p were identified as shared regulators. Cadherin expression also showed associations with immune modulators and drug response. Functionally, CDH1 and CDH2 knockdown suppressed proliferation, migration, and tumor growth.</p><p><strong>Conclusion: </strong>Cadherin genes, particularly CDH3, show diagnostic and prognostic relevance in HNSC, while CDH1 and CDH2 contribute to tumor cell growth and migration. Further studies are required to determine their therapeutic potential.</p>","PeriodicalId":23856,"journal":{"name":"World Journal of Surgical Oncology","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2026-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13663313/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148413111","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Spread through air spaces as an independent prognostic factor in resected lung adenocarcinoma: the role of resection type.","authors":"Reyhan Ertan, Emine Bozkurtlar, Korkut Bostancı","doi":"10.1186/s12957-026-04490-5","DOIUrl":"10.1186/s12957-026-04490-5","url":null,"abstract":"<p><strong>Background: </strong>Spread through air spaces (STAS) has emerged as an independent prognostic factor in lung adenocarcinoma, yet its interaction with resection type remains poorly defined. We aimed to evaluate the prognostic impact of STAS on overall survival (OS) and disease-free survival (DFS) according to resection type in surgically resected lung adenocarcinoma.</p><p><strong>Methods: </strong>We retrospectively analysed 252 patients who underwent resection for lung adenocarcinoma at a single institution between 2016 and 2023. Patients were stratified into four groups by STAS status and resection type. Overall survival and DFS were estimated using Kaplan-Meier analysis with log-rank testing. Multivariable Cox regression was performed to identify independent prognostic factors.</p><p><strong>Results: </strong>STAS was present in 148 patients (58.7%). Among the four groups, patients who underwent STAS-positive sublobar resection demonstrated the worst prognosis, with a mortality rate of 50.0%, a median OS of 98 months, and a 5-year OS of 51.3%. STAS-positive lobar resection patients achieved a 5-year OS of 70.1%, comparable to STAS-negative lobar patients (67.8%). On multivariable Cox regression, STAS-positive sublobar resection was an independent predictor of mortality (HR 2.29, 95% CI 1.10-4.75; p = 0.026), as were lymphovascular invasion (HR 2.28; p = 0.001) and visceral pleural invasion (HR 2.14; p = 0.020). No significant difference in DFS was observed across groups (p = 0.963), suggesting that STAS primarily influences prognosis through its impact on overall survival rather than recurrence.</p><p><strong>Conclusions: </strong>STAS positivity combined with sublobar resection independently predicts poor overall survival in lung adenocarcinoma. STAS status should inform surgical decision-making when sublobar resection is considered.</p>","PeriodicalId":23856,"journal":{"name":"World Journal of Surgical Oncology","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2026-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13628931/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148406047","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Retraction Note: Roles of KAI1 and nm23 in lymphangiogenesis and lymph metastasis of laryngeal squamous cell carcinoma.","authors":"Zongzhu Zheng, Ruihua Tian, Ping Wang","doi":"10.1186/s12957-026-04491-4","DOIUrl":"10.1186/s12957-026-04491-4","url":null,"abstract":"","PeriodicalId":23856,"journal":{"name":"World Journal of Surgical Oncology","volume":"24 1","pages":""},"PeriodicalIF":2.8,"publicationDate":"2026-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13340362/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148406033","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Serum 5'-tiRNA-iMet-CAT is a novel biomarker for the diagnosis and early postoperative assessment of hepatocellular carcinoma.","authors":"Yan Hong, Shiyi Qin, Xian Li, Rui Ding, Shaoqing Ju","doi":"10.1186/s12957-026-04480-7","DOIUrl":"10.1186/s12957-026-04480-7","url":null,"abstract":"<p><strong>Background: </strong>Hepatocellular carcinoma (HCC) is one of the most common digestive system malignancies and a leading cause of cancer-related mortality worldwide. Alpha-fetoprotein (AFP), although widely used, shows limited sensitivity in early HCC, leading to missed diagnoses. Novel molecular markers that complement existing biomarkers are urgently needed. tRNA-derived small RNAs (tsRNAs), a newly recognized class of noncoding RNAs generated from transfer RNAs, are abundant in cancer cells and body fluids and have emerging roles in tumourigenesis. This study aimed to identify dysregulated tsRNAs in HCC and evaluate their clinical value as biomarkers.</p><p><strong>Methods: </strong>We performed high-throughput sequencing on 3 pairs of HCC tissues and their matched adjacent normal tissues to profile 5'-tiRNA-iMet-CAT, validating its serum levels by quantitative reverse transcription PCR (qRT-PCR). Molecular features and stability were confirmed by electrophoresis, sequencing, and freeze-thaw assays. We assessed clinical correlations, diagnostic potential, and predicted target genes via multiple databases with Gene Ontology and Kyoto Encyclopedia of Genes and Genomes enrichment analysis.</p><p><strong>Results: </strong>Serum 5'-tiRNA-iMet-CAT was significantly elevated in HCC patients versus healthy controls. Its high expression correlated with poor differentiation, larger tumour size, and advanced Barcelona Clinic Liver Cancer stage (all P < 0.05). Receiver operating characteristic analysis confirmed strong diagnostic performance, with levels markedly decreasing postoperatively (P < 0.0001).</p><p><strong>Conclusion: </strong>Serum 5'-tiRNA-iMet-CAT is stable, specific, and clinically relevant. It may serve as a promising noninvasive biomarker for HCC diagnosis and evaluating short-term therapeutic response during the early postoperative phase.</p>","PeriodicalId":23856,"journal":{"name":"World Journal of Surgical Oncology","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2026-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13625232/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148406053","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}