Veterinary dermatology最新文献

{"title":"Putative erythema annulare centrifugum in two Peruvian hairless and one Chinese crested dog.","authors":"Renzo Venturo, Lluís Ferrer, Pauline Bernard, Emmanuella Guenova, Maxence Delverdier, Marie-Christine Cadiergues, Daniel Combarros","doi":"10.1111/vde.13369","DOIUrl":"10.1111/vde.13369","url":null,"abstract":"<p><p>Erythema annulare centrifugum (EAC) is an inflammatory skin condition characterised in humans by distinctive annular erythematous lesions. Three hairless dogs were examined with clinical and histological features suggestive of EAC. Oral or topical glucocorticoid administration led to complete clinical resolution.</p>","PeriodicalId":23599,"journal":{"name":"Veterinary dermatology","volume":" ","pages":"712-718"},"PeriodicalIF":1.4,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144476857","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Machine Learning Model for an App-Based Tool to Assist With the Diagnosis of Canine Atopic Dermatitis.","authors":"Xavier Langon, Mathieu Montoya, Isabelle Gourdon","doi":"10.1111/vde.70031","DOIUrl":"https://doi.org/10.1111/vde.70031","url":null,"abstract":"<p><strong>Background: </strong>Canine atopic dermatitis (cAD) is a chronic condition requiring life-long management. Accurate diagnosis can be challenging, with no reliable diagnostic test.</p><p><strong>Objectives: </strong>This study aimed to generate a simple diagnostic model for cAD.</p><p><strong>Materials and methods: </strong>Machine learning by Random Forest was applied to metadata from a prospective dataset of clinical cases definitively diagnosed with cAD alone or another dermatosis. The dataset underwent a division of 67% for training and 33% for testing, with the model being trained via stratified K-fold cross-validation on the former portion, while performance assessment was conducted on the latter portion. Nine referral clinicians across four European countries contributed 645 cases.</p><p><strong>Results: </strong>Modelling confirmed the value of the four tested metadata on a dog's history and reduced the initial 15 lesion locations tested to three. Metadata for the final model were: predisposed breed (any from a list of 31), predominantly indoor life, dermatitis onset age between 6 months and 3 years, dermatitis chronic, recurrent or a permanent background. Lesion locations were axilla, inguinal and other. Diagnostic prediction was 95% sensitive and 84% specific.</p><p><strong>Conclusions and clinical relevance: </strong>This model is a relevant prototype for an app-based tool to support general practitioners in the diagnosis of cAD alongside existing tests. It has high sensitivity and specificity based on four questions and three lesion locations obtained from a standard history and clinical examination.</p>","PeriodicalId":23599,"journal":{"name":"Veterinary dermatology","volume":" ","pages":""},"PeriodicalIF":1.4,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145186831","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Capripoxvirus Infections: Advances in Diagnosis and Strategic Control Measures.","authors":"Soumajit Sarkar, Muthannan Andavar Ramakrishnan, Monika Kumar, Siddhartha Narayan Joardar, Nikhil Kanasinakatte Channabasappa, Kanaka Krishnamurthy Kareningappa, Ganesh Narayanrao Aderao, Amit Kumar","doi":"10.1111/vde.70028","DOIUrl":"https://doi.org/10.1111/vde.70028","url":null,"abstract":"<p><p>Sheeppox virus (SPPV), goatpox virus (GTPV) and lumpy skin disease virus (LSDV) belong to the genus Capripoxvirus (CaPV) within the family Poxviridae. These transboundary and highly infectious viruses cause substantial economic losses by affecting the productivity of both small and large ruminants. Clinical manifestations include cutaneous lesions (skin nodules and pustular lesions), lymphadenopathy, pneumonia, reduced milk yield, mastitis, infertility and abortion. The diagnosis is based on a combination of clinical signs, virus isolation, serology and PCR/real-time PCR. Recent advancements have significantly improved the sensitivity and specificity of CaPV detection and differentiation. These include multiplexed serological assays, isothermal DNA amplification methods such as recombinase polymerase reaction, CRISPR-Cas12a fluorescence assays and advanced DNA sequencing platforms. In enzootic regions, strategic control measures should include public awareness, vector control, early detection, vaccination, use of ethnoveterinary formulations, veterinary care, strict biosecurity and movement restrictions. The live attenuated vaccines remain the most suitable option for these regions owing to their efficacy. Cross-protective CaPV vaccine strains also support heterologous vaccination strategies. Emerging multivalent and recombinant vaccines offer promising avenues for providing broad protection and simplifying disease management. Overall, it is essential to break the viral transmission cycle to mitigate the economic losses.</p>","PeriodicalId":23599,"journal":{"name":"Veterinary dermatology","volume":" ","pages":""},"PeriodicalIF":1.4,"publicationDate":"2025-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145132004","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical Features, Treatment and Outcomes of Dogs With Psoriasiform Lichenoid Dermatosis Associated With Calcineurin Inhibitor Therapy.","authors":"E R Davis, E A Mauldin, C L Cain, S Cole, C W Bradley","doi":"10.1111/vde.70014","DOIUrl":"https://doi.org/10.1111/vde.70014","url":null,"abstract":"<p><strong>Background: </strong>Psoriasiform lichenoid dermatosis (PLD) is a rare lesion in dogs receiving calcineurin inhibitors, associated with staphylococcal infection.</p><p><strong>Objectives: </strong>To define the clinical features of dogs with a histopathologic diagnosis of PLD.</p><p><strong>Results: </strong>Twenty-eight dogs were included in this retrospective study. PLD was focal (4/28), multifocal (17/28) or regional/generalised (7/28). Twenty-seven of 28 dogs received a calcineurin inhibitor with a median time to lesion onset of 6 months (1-24 months). Twenty-three of 28 dogs received ciclosporin (ciclosporin alone: 15/23; ciclosporin with ketoconazole: 7/23). Formulations included generic modified ciclosporin (12/23), brand-name modified ciclosporin (7/23), compounded modified ciclosporin (1/23) or unknown formulation (3/22). Four dogs had gingival hyperplasia or paw-pad hyperkeratosis. Four dogs received topical tacrolimus. No breed or sex predilection was found. The median age of onset was 7 years (3-12 years). In 22/28 dogs, bacteria were seen on lesional cytology, and Staphylococcus pseudintermedius was isolated with bacterial culture from nine dogs. Short-read whole genome sequencing was performed on three isolates. Most dogs received antimicrobials before (14/28) and/or after diagnosis (22/28 dogs).</p><p><strong>Outcomes/clinical relevance: </strong>PLD occurs in adult dogs irrespective of breed with varied forms of calcineurin inhibitors. Twenty of 28 dogs achieved > 50% improvement or complete (100%) lesion resolution after topical and/or systemic antimicrobial therapy and discontinuation with or without dose reduction of the calcineurin inhibitor.</p>","PeriodicalId":23599,"journal":{"name":"Veterinary dermatology","volume":" ","pages":""},"PeriodicalIF":1.4,"publicationDate":"2025-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145114240","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical, Histopathological and Molecular Characterisation of Canine Epitheliotropic Cutaneous T-Cell Lymphoma With Cytotoxic Interface Dermatitis: A Retrospective Case Series.","authors":"L Smith, F Banovic, M Pariser, K Trainor","doi":"10.1111/vde.70029","DOIUrl":"https://doi.org/10.1111/vde.70029","url":null,"abstract":"<p><strong>Background: </strong>Apoptotic keratinocytes have been described with canine epitheliotropic cutaneous T-cell lymphoma (eCTCL) without further detailed characterisation of this feature.</p><p><strong>Hypothesis/objectives: </strong>This study aims to characterise confirmed eCTCL cases enriched with apoptotic keratinocytes as a novel cytotoxic variant of canine eCTCL.</p><p><strong>Animals: </strong>Canine eCTCL cases from a veterinary pathology diagnostic laboratory database were searched from 2018 to 2024.</p><p><strong>Materials and methods: </strong>Haematoxylin and eosin-stained slides were examined for evidence of lymphocytes, apoptotic keratinocytes with lymphocytic satellitosis, and epitheliotropism in the lower half of the epidermis and adnexal structures by a board-certified veterinary pathologist. Immunohistochemical (IHC) staining for CD3 and CD20 was performed in addition to clinical follow-up with response to treatment, and PCR for Antigen Receptor Rearrangement (PARR) assay (T and B cell).</p><p><strong>Results: </strong>Six cases with representative features were identified. Various breeds were affected with a median age of 10 years at presentation. Skin lesions included generalised crusting, scaling, erythema and erosions/ulcerations; mucocutaneous junctions were involved in three of six dogs. Histopathological results confirmed an interface cytotoxic pattern eCTCL in all cases, marked by lymphocytic epitheliotropism and apoptotic keratinocytes. IHC staining demonstrated > 90% strong CD3⁺ T-cell immunoreactivity in the epidermis and follicular epithelium in all cases. All six confirmed cases showed clonality for the T-cell receptor gene using PARR analysis.</p><p><strong>Conclusions and clinical relevance: </strong>This cytotoxic variant of canine eCTCL clinically and histologically can resemble other cutaneous diseases with cytotoxic dermatitis (e.g., hyperkeratotic erythema multiforme). IHC and clonality testing and monitoring response to treatment may be necessary for definitive diagnosis.</p>","PeriodicalId":23599,"journal":{"name":"Veterinary dermatology","volume":" ","pages":""},"PeriodicalIF":1.4,"publicationDate":"2025-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145114302","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bacteriophage and Fusidic Acid Have Synergistic Effect Against Meticillin-Resistant Staphylococcus pseudintermedius in Ex Vivo Canine Dermis Model.","authors":"Sarah Ehling, Elisa Peh, Hilke Oltmanns, Jessica Meissner, Sophie Kittler, Christina Puff, Jutta Verspohl, Mathias Müsken, Madeleine Plötz, Andrea Vanessa Volk","doi":"10.1111/vde.70030","DOIUrl":"https://doi.org/10.1111/vde.70030","url":null,"abstract":"<p><strong>Background: </strong>Antimicrobial stewardship has become vital given the progressive emergence of multidrug-resistant bacteria, and novel approaches to the treatment of bacterial infections are needed. Recently, reported synergistic effects of antibacterial drugs and bacteriophage therapy have revealed promising applications for the management of meticillin-resistant staphylococcal infections.</p><p><strong>Objectives: </strong>The objective of this study was to investigate the response of meticillin-resistant Staphylococcus pseudintermedius (MRSP) to treatment with a newly isolated, lytic MRSP-specific bacteriophage. Furthermore, a postulated synergism between phage and fusidic acid was examined in a canine ex vivo dermis model.</p><p><strong>Material and methods: </strong>Skin was harvested from the lateral thorax of a euthanised dog, clipped, the subcutis removed, and epidermis cleaved via a modified salt-split technique. The ex vivo dermis model established in Franz diffusion cells was inoculated with 1 × 10⁷ colony-forming units (cfu) of a clinical MRSP strain for 16 h. Then, experimental groups were treated with phage vB_SpsS_LmqsKl44-4 at a concentration of 2 × 10⁶ plaque-forming units and fusidic acid 0.4 mg alone or in combination for an additional 8 h.</p><p><strong>Results: </strong>Histopathological results showed that colonies of MRSP reached the superficial dermis and entered hair follicles. Co-treatment with fusidic acid and phage significantly reduced the amount of MRSP after 8 h.</p><p><strong>Conclusions and clinical relevance: </strong>In conclusion, topical co-treatment with fusidic acid and a phage could be a promising approach to the treatment of canine MRSP pyoderma.</p>","PeriodicalId":23599,"journal":{"name":"Veterinary dermatology","volume":" ","pages":""},"PeriodicalIF":1.4,"publicationDate":"2025-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145087570","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of Chlorhexidine-Containing Shampoos: In Vitro Efficacy Against Staphylococcus pseudintermedius and Lathering Ability.","authors":"Emily E Binversie, Jason B Pieper, Darren J Berger","doi":"10.1111/vde.70026","DOIUrl":"https://doi.org/10.1111/vde.70026","url":null,"abstract":"<p><strong>Background: </strong>The antibacterial efficacy of chlorhexidine shampoo is directly affected by formulation and bathing factors.</p><p><strong>Hypothesis/objective: </strong>To evaluate the in vitro antibacterial efficacy of chlorhexidine-containing shampoos at various dilutions and to compare their lathering ability.</p><p><strong>Animals: </strong>No animals were utilised in this study.</p><p><strong>Materials and methods: </strong>Eight chlorhexidine-containing shampoos, three non-chlorhexidine shampoos, and a 2% chlorhexidine gluconate solution were tested against one American Type Culture Collection (ATCC) meticillin-sensitive Staphylococcus pseudintermedius and one institutional meticillin-resistant S. pseudintermedius isolate. The effect of formulation on minimum inhibitory concentration (MIC) was determined using a broth microdilution method. The first dilution that had no visible growth and four preceding dilutions were plated on blood agar to determine the minimum bactericidal concentration (MBC). Lathering ability and lather stability were assessed using a modified cylinder shake method. MIC and MBC were compared for the dilution ratio and chlorhexidine gluconate/digluconate concentration using a Kruskal-Wallis test with Bonferroni correction (p < 0.001).</p><p><strong>Results: </strong>All products had a detectable MIC. Statistically significant differences between MIC and MBC were observed between shampoos that were not based on chlorhexidine concentration alone. Two non-chlorhexidine shampoos had no detectable MBC. Over time, all shampoos had a significant decrease in lather height. Lathering ability significantly differed between some shampoos.</p><p><strong>Conclusions and clinical relevance: </strong>This preliminary study suggests that shampoo formulation and not just chlorhexidine concentration impacts efficacy. Further investigation with more robust numbers of bacterial isolates and large-scale head-to-head clinical trials is required to determine if the reported in vitro variance has clinical significance.</p>","PeriodicalId":23599,"journal":{"name":"Veterinary dermatology","volume":" ","pages":""},"PeriodicalIF":1.4,"publicationDate":"2025-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145030700","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Single Cold Atmospheric Plasma Therapy May Improve the Treatment Outcome of Canine Otitis Externa With Secondary Infection.","authors":"Ralf S Mueller, Cosima Bouassiba","doi":"10.1111/vde.70027","DOIUrl":"https://doi.org/10.1111/vde.70027","url":null,"abstract":"<p><strong>Background: </strong>Otitis externa (OE) with secondary bacterial or yeast infection is a common problem in small animal practice. Cold physical plasma (CPP) has been reported to have antimicrobial activity in vitro.</p><p><strong>Hypothesis/objectives: </strong>This randomised, blinded, prospective study assessed the influence of additional CPP treatment on the recovery of canine OE with secondary infection.</p><p><strong>Animals: </strong>Twenty-one dogs with bilateral clinical OE and cytological evidence of infection were included.</p><p><strong>Materials and methods: </strong>An ear flush was performed with saline solution in all dogs. Additionally, one ear of each dog, chosen in a prospective randomised fashion, was treated with CPP for 30 s. Afterwards, both ears were treated with a depot ear medication containing betamethasone, terbinafine and florfenicol. Seven days later, the depot medication was administered again as recommended by the manufacturer. On Day (D) 0, D7 and D21, a clinical otic score and a validated semiquantitative cytological score were compared with a Friedman test and Dunn's multiple comparison test.</p><p><strong>Results: </strong>Ears treated additionally with CPP showed lower otic scores after 21 days compared to nontreated ears, although this difference was not significant (p = 0.08). Cytological scores improved over 21 days with cocci in CPP-treated (p = 0.003) and nontreated ears (p = 0.02). With yeast, there was significant improvement in CPP-treated (p = 0.0002) ears in contrast to nontreated ears. With rods, the improvement was not statistically significant in either group.</p><p><strong>Conclusions and clinical relevance: </strong>CPP treatment seems to be a promising option as an additional treatment after ear flushing.</p>","PeriodicalId":23599,"journal":{"name":"Veterinary dermatology","volume":" ","pages":""},"PeriodicalIF":1.4,"publicationDate":"2025-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145030664","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development of a Four-Language Questionnaire to Investigate Environmental Risk Factors for the Development of Canine Atopic Dermatitis and to Monitor Disease Course and Progression.","authors":"Patricia Clara-Maria Rhodius, Nina Fischer, Ana Rostaher, Franco Martini, Edwin Chapman, Sabrina Audergon, Stefan Hobi, Georg Lehner, Sylvie Wilhelm, Noëmi van Oordt, Claude Favrot, Malwina Kowalska","doi":"10.1111/vde.70024","DOIUrl":"https://doi.org/10.1111/vde.70024","url":null,"abstract":"<p><strong>Background: </strong>The chronic and multifactorial character of canine atopic dermatitis (cAD) often leads to poor disease control and treatment dissatisfaction. Environmental factors are likely to contribute to the disease development and may play a more important role than assumed previously. This opens new research directions that require an appropriate tool to obtain useful data from large representative study populations.</p><p><strong>Hypothesis/objectives: </strong>A tool such as a questionnaire is suitable for obtaining high-quality data to investigate the pathogenesis of cAD and monitor the disease.</p><p><strong>Materials and methods: </strong>To assure the tool's validity and reliability, the development process of this four-language questionnaire (original language German) included two pilot tests (with owners' interviews and questionnaire evaluation sheets), test-retest assessment, content validity evaluation and a structured translation and back-translation into three languages (English, Italian and French).</p><p><strong>Results: </strong>The development process took place between June 2024 and December 2024. The preliminary questionnaire comprised 107 questions. The pilot tests (round 1 = four participants, round 2 = two participants) resulted in a revision of 31 questions and the deletion of three. The test-retest assessment revealed an Intraclass Correlation Coefficient of 0.80. The panel of (six) experts evaluated the questionnaire with a content validity index of 0.99. The translation and back-translation process revealed that only minor adjustments were sufficient to guarantee the validity and reliability across languages.</p><p><strong>Conclusions and clinical relevance: </strong>The comprehensive development process ensures high validity and reliability of the questionnaire, indicating that such a process can not only positively impact the quality of the developed tool, but also create a reliable basis for the generation of accurate and less biased data.</p>","PeriodicalId":23599,"journal":{"name":"Veterinary dermatology","volume":" ","pages":""},"PeriodicalIF":1.4,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144970866","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of a Spray Containing Occlusive Agents, Humectants and Physiological Lipids on Skin Hydration of Healthy Dogs When Applied After Bathing With a Chlorhexidine 2%/Miconazole 2% Shampoo.","authors":"Adamantia Pseftogka, Elisabeta Samuel Badulescu, Manolis K Chatzis, Manolis N Saridomichelakis","doi":"10.1111/vde.70025","DOIUrl":"https://doi.org/10.1111/vde.70025","url":null,"abstract":"<p><strong>Background: </strong>Normal hydration of the canine epidermis is imperative for cutaneous homeostasis. Xerosis may be encountered in canine atopic dermatitis and is aggravated by topical antiseptics.</p><p><strong>Hypothesis and objectives: </strong>To evaluate the hydrating properties and the safety of a spray (Sensiderm spray; MP Labo) when applied after shampooing healthy dogs with a chlorhexidine 2%/miconazole 2% product.</p><p><strong>Animals: </strong>Twelve clinically healthy, privately owned dogs.</p><p><strong>Materials and methods: </strong>Dogs were clipped on the top of the head (control site), right and left lateral thorax. They were bathed on the body trunk with the chlorhexidine 2%/miconazole 2% shampoo and subsequently sprayed with Sensiderm on their randomly selected right or left side of the thorax. Skin hydration was measured by electrical capacitance using a corneometer on the three sites before (time point [T]0), and 1-2 h (T1), 6 h (T2), 24 h (T3), 48 h (T4) and 72 h (T5) after interventions.</p><p><strong>Results: </strong>Two-way repeated-measures ANOVA showed a significant effect of time (p = 0.015) and a significant time-treatment interaction (p = 0.023) on skin hydration. One-way repeated-measures ANOVA showed that the effect of time was significant only on the Sensiderm spray-treated site, where skin hydration increased over baseline at T1 (p = 0.009; 95% confidence interval [CI] = 3.158-17.231), peaked at T2 (p ≤ 0.014 and 95% CI ≥ 1.680 compared with T0, T3, T4 and T5) and remained increased at T3 (p ≤ 0.037 and 95% CI ≥ 0.482 compared with T0 and T5). No treatment-related adverse effects were seen.</p><p><strong>Conclusions and clinical relevance: </strong>Sensiderm spray was safe, and it increased hydration of healthy canine skin for ≥ 24 h.</p>","PeriodicalId":23599,"journal":{"name":"Veterinary dermatology","volume":" ","pages":""},"PeriodicalIF":1.4,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144970911","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}