Veterinary dermatology最新文献

{"title":"Efficacy of Combination Oclacitinib and Lokivetmab Therapies After Monotherapeutic Failure in 44 Dogs: A Retrospective Study.","authors":"Jeremy C Bachtel, McKenna Snidow","doi":"10.1111/vde.70034","DOIUrl":"10.1111/vde.70034","url":null,"abstract":"<p><strong>Background: </strong>Oclacitinib and lokivetmab are generally effective monotherapies for the treatment of canine allergic dermatitis yet treatment failures may occur.</p><p><strong>Objective: </strong>To evaluate the efficacy of the combination of oclacitinib-lokivetmab therapy (COLT) in dogs that previously failed monotherapy.</p><p><strong>Animals: </strong>Forty-four client-owned dogs diagnosed with allergic dermatitis that did not respond to both oclacitinib and lokivetmab as monotherapies were then treated with COLT.</p><p><strong>Results: </strong>Twenty-seven of 44 (61.4%) dogs responded adequately to COLT based on a ≥ 2 cm reduction in the pruritus Visual Analog Scale (pVAS) score from baseline and client/clinician consensus on improvement. In dogs that responded, the mean pVAS for monotherapy (oclacitinib and lokivetmab group data combined) was 6.87 of 10 and fell to 2.67 of 10 after COLT (61.1% decrease; p < 0.0001). No adverse effects were noted with COLT.</p><p><strong>Conclusions and clinical relevance: </strong>This study suggests that in dogs not adequately responsive to oclacitinib or lokivetmab monotherapy, COLT may provide superior control of pruritus.</p>","PeriodicalId":23599,"journal":{"name":"Veterinary dermatology","volume":" ","pages":"287-292"},"PeriodicalIF":1.4,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145445966","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"VETCOP: A New Tool for Understanding Pet Owner Topical Steroid Treatment Phobias in the Treatment of Canine Atopic Dermatitis: A Study From China and Singapore.","authors":"Hock Siew Han, Di Zhang, Fan Wang, Xinghui Chen, Jing Jing Ye, Xiang Tang, Qianchun Cui, Xiaohui Quan, Siyang Li, Taranpreet Rai, Kevin Wells","doi":"10.1111/vde.70040","DOIUrl":"10.1111/vde.70040","url":null,"abstract":"<p><strong>Background: </strong>Topical corticosteroids (TCS) phobia refers to the negative feelings and beliefs related to TCS. TCS phobia may lead to a lack of adherence to therapy and treatment failure in patients diagnosed with atopic dermatitis.</p><p><strong>Objectives: </strong>To quantify TCS phobia amongst pet owners of dogs diagnosed with canine atopic dermatitis (cAD) with the hypothesis that there is no TCS phobia.</p><p><strong>Materials and methods: </strong>A validated topical corticosteroid phobia (TOPICOP) questionnaire adapted for veterinary use-termed Veterinary Topical Corticosteroid Phobia (VETCOP)-plus four additional questions were uploaded onto an online platform. Pet owners of dogs diagnosed with cAD from China and Singapore were recruited into the study via a QR code, and data were statistically analysed.</p><p><strong>Results: </strong>In total, 363 respondents (276 female, 87 male) were enrolled in this study. The global median VETCOP score was 52.8%, with females exhibiting higher TCS scores compared to males, and older (> 60-year-old) pet owners expressing higher TCS scores than other age brackets. Surveyed pet owners expressed utmost concerns about their need for reassurances when TCS are prescribed and their willingness to pay for more expensive allergic medication other than glucocorticoids (topical or systemic).</p><p><strong>Conclusions and clinical relevance: </strong>Based on the findings of this study, TCS phobia could potentially be a widespread problem in veterinary dermatology, and veterinary surgeons may be the only source of information regarding the use of TCS on pets. The failure to communicate or reassure pet owners when TCS is prescribed may lead to therapeutic failure.</p>","PeriodicalId":23599,"journal":{"name":"Veterinary dermatology","volume":" ","pages":"319-330"},"PeriodicalIF":1.4,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145805606","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy of Der f 2/Zen 1-LAMP1 Plasmid-Based Vaccine Immunotherapy in Dogs With Atopic Dermatitis: A Proof-of-Concept Study.","authors":"Petra Bizikova, Chigusa Matsumoto, Shoji Ogino, Toshihiro Tsukui, Kim Love, Marcy Murphy, Ina Herrmann","doi":"10.1111/vde.70037","DOIUrl":"10.1111/vde.70037","url":null,"abstract":"<p><strong>Background: </strong>DNA-based vaccination rapidly induces strong cellular and humoral immune responses, which may be enhanced by inclusion of lysosomal-associated membrane protein-1 (LAMP).</p><p><strong>Objectives: </strong>This proof-of-concept study evaluated the efficacy and safety of a Der f 2/Zen 1-LAMP-based DNA vaccine immunotherapy in client-owned dogs with nonseasonal AD sensitised to Dermatophagoides farinae (Df).</p><p><strong>Animals: </strong>Fifteen dogs positive for Df only and 20 dogs with reactivity to additional environmental allergens received either a low (0.5 mg/0.1 mL) or high (2 mg/0.4 mL) dose of the vaccine intradermally.</p><p><strong>Materials and methods: </strong>Four doses of vaccine were administered every 2 weeks. Pruritus, Canine Atopic Dermatitis Extent and Severity Index (CADESI)-04, average daily medication scores (AvdMS) and adverse events (AE) were recorded over 24 weeks. Owner perception of treatment efficacy (OGATE) was assessed at the end.</p><p><strong>Results: </strong>Pruritus and CADESI-04 improved regardless of the sensitisation profile and the vaccine dose. After 24 weeks, despite a statistically insignificant reduction of AvdMS, 71%, 46% and 86% of dogs reached PVAS < 3.6, PVAS < 2 and CADESI-04 < 10, respectively. There was no statistically significant effect of AvdMS on PVAS or CADESI-04, meaning that the concurrently administered topical and/or systemic treatment(s) were unlikely to have been responsible for the observed PVAS and CADESI-04 reduction. Twenty-one owners (60%) rated the vaccine efficacy as good-to-excellent. No severe AEs were reported.</p><p><strong>Conclusions and clinical relevance: </strong>These results of this proof-of-concept study support not only the safety of DNA vaccine immunotherapy in dogs with AD, but also its potential clinical benefits. A double-blinded, ≥ 12 month long, controlled study with more subjects should follow to further confirm the true efficacy of this vaccine.</p>","PeriodicalId":23599,"journal":{"name":"Veterinary dermatology","volume":" ","pages":"306-318"},"PeriodicalIF":1.4,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12967877/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145597616","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Congenital Non-Epidermolytic Ichthyosis in Two Littermate Mixed-Breed Yorkshire Terriers.","authors":"C Lorente-Méndez, S Peña, A Cerezo","doi":"10.1111/vde.70033","DOIUrl":"10.1111/vde.70033","url":null,"abstract":"<p><p>Congenital non-epidermolytic ichthyosis was diagnosed in two littermate mixed-breed Yorkshire terrier puppies. Histopathological results confirmed lamellar orthokeratosis; genetic testing for known mutations was negative. Topical treatment improved clinical signs, yet relapse occurred upon discontinuation. This case expands the breeds affected and emphasises the need for life-long management.</p>","PeriodicalId":23599,"journal":{"name":"Veterinary dermatology","volume":" ","pages":"222-226"},"PeriodicalIF":1.4,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145337530","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pinnal Parakeratotic Hyperkeratosis Consistent With Zinc-Responsive Dermatosis in 16 French Bulldogs.","authors":"Rachel J Dubin, Charles W Bradley, M Kelly Keating, Lisa A Murphy, Wayne S Rosenkrantz","doi":"10.1111/vde.70039","DOIUrl":"10.1111/vde.70039","url":null,"abstract":"<p><strong>Background: </strong>Zinc-responsive dermatosis, characterised by parakeratotic hyperkeratosis, is most commonly reported in Arctic breeds and, more recently, suspected in Boston terriers.</p><p><strong>Objectives: </strong>To describe the clinical and histological features of pinnal parakeratotic hyperkeratosis in French bulldogs, evaluate the response to zinc supplementation, and compare tissue zinc concentrations between affected and unaffected dogs.</p><p><strong>Materials and methods: </strong>Sixteen French bulldogs with histologically confirmed parakeratotic hyperkeratosis were identified retrospectively across the United States. Follow-up information was obtained from medical records and owner email surveys. Tissue zinc concentrations were measured by inductively coupled plasma mass spectrometry in skin biopsy samples from affected and control French bulldogs.</p><p><strong>Results: </strong>All 16 dogs had bilateral pinnal hyperkeratosis; six also had lesions on the nasal bridge, scrotum or tail. Of 12 dogs that received oral zinc supplementation, eight (67%) improved or achieved complete resolution, including four that responded to zinc supplementation alone. Relapse occurred in four dogs following discontinuation of supplementation, with improvement in three upon reintroduction. Tissue zinc concentrations did not differ significantly between affected and control biopsy samples.</p><p><strong>Conclusions and clinical relevance: </strong>French bulldogs may be predisposed to pinnal parakeratotic hyperkeratosis suggestive of zinc-responsive dermatosis. Zinc methionine supplementation at approximately 2 mg/kg/day was associated with clinical improvement in most cases. Prospective studies are warranted to clarify pathogenesis, compare zinc formulations, and establish diagnostic and therapeutic guidelines.</p>","PeriodicalId":23599,"journal":{"name":"Veterinary dermatology","volume":" ","pages":"274-286"},"PeriodicalIF":1.4,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145716058","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical, Histopathological and Molecular Characterisation of Canine Epitheliotropic Cutaneous T-Cell Lymphoma With Cytotoxic Interface Dermatitis: A Retrospective Case Series.","authors":"L Smith, F Banovic, M Pariser, K Trainor","doi":"10.1111/vde.70029","DOIUrl":"10.1111/vde.70029","url":null,"abstract":"<p><strong>Background: </strong>Apoptotic keratinocytes have been described with canine epitheliotropic cutaneous T-cell lymphoma (eCTCL) without further detailed characterisation of this feature.</p><p><strong>Hypothesis/objectives: </strong>This study aims to characterise confirmed eCTCL cases enriched with apoptotic keratinocytes as a novel cytotoxic variant of canine eCTCL.</p><p><strong>Animals: </strong>Canine eCTCL cases from a veterinary pathology diagnostic laboratory database were searched from 2018 to 2024.</p><p><strong>Materials and methods: </strong>Haematoxylin and eosin-stained slides were examined for evidence of lymphocytes, apoptotic keratinocytes with lymphocytic satellitosis, and epitheliotropism in the lower half of the epidermis and adnexal structures by a board-certified veterinary pathologist. Immunohistochemical (IHC) staining for CD3 and CD20 was performed in addition to clinical follow-up with response to treatment, and PCR for Antigen Receptor Rearrangement (PARR) assay (T and B cell).</p><p><strong>Results: </strong>Six cases with representative features were identified. Various breeds were affected with a median age of 10 years at presentation. Skin lesions included generalised crusting, scaling, erythema and erosions/ulcerations; mucocutaneous junctions were involved in three of six dogs. Histopathological results confirmed an interface cytotoxic pattern eCTCL in all cases, marked by lymphocytic epitheliotropism and apoptotic keratinocytes. IHC staining demonstrated > 90% strong CD3⁺ T-cell immunoreactivity in the epidermis and follicular epithelium in all cases. All six confirmed cases showed clonality for the T-cell receptor gene using PARR analysis.</p><p><strong>Conclusions and clinical relevance: </strong>This cytotoxic variant of canine eCTCL clinically and histologically can resemble other cutaneous diseases with cytotoxic dermatitis (e.g., hyperkeratotic erythema multiforme). IHC and clonality testing and monitoring response to treatment may be necessary for definitive diagnosis.</p>","PeriodicalId":23599,"journal":{"name":"Veterinary dermatology","volume":" ","pages":"257-268"},"PeriodicalIF":1.4,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145114302","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ESVD/ECVD Congress Abstracts.","authors":"","doi":"10.1111/vde.70046","DOIUrl":"10.1111/vde.70046","url":null,"abstract":"","PeriodicalId":23599,"journal":{"name":"Veterinary dermatology","volume":" ","pages":"163-199"},"PeriodicalIF":1.4,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145901044","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Successful Treatment of Idiopathic Follicular Mucinosis in a Golden Retriever: Clinical, Dermoscopic and Histopathological Findings.","authors":"Elisa Theuerkauff, Martina Dettwiler, Maren Dölle","doi":"10.1111/vde.70067","DOIUrl":"https://doi.org/10.1111/vde.70067","url":null,"abstract":"<p><p>Follicular mucinosis is a rare form of alopecia in dogs characterised by deposition of mural mucin, leading to hair loss, favouring the face, neck and limbs. This report documents its histopathological features, dermoscopic findings, clinical course and successful treatment in a golden retriever dog with follicular mucinosis.</p>","PeriodicalId":23599,"journal":{"name":"Veterinary dermatology","volume":" ","pages":""},"PeriodicalIF":1.4,"publicationDate":"2026-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147575637","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Canine Sarcoidosis Treated Successfully With Oclacitinib: A Case Report.","authors":"Lotta Pänkälä, Kirsti Schildt, Anna Huupponen, Antti Sukura, Seppo Saari","doi":"10.1111/vde.70070","DOIUrl":"https://doi.org/10.1111/vde.70070","url":null,"abstract":"<p><p>A male Finnish Lapphund presented with widespread papular skin lesions, which were diagnosed as cutaneous sarcoidosis based on histopathological results. Multiple diagnostic techniques, including bacterial and fungal culture, special staining, electron microscopy and in situ hybridisation, failed to identify a specific causative agent. Remission was achieved with oral oclacitinib.</p>","PeriodicalId":23599,"journal":{"name":"Veterinary dermatology","volume":" ","pages":""},"PeriodicalIF":1.4,"publicationDate":"2026-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147522026","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Management and Clinical Outcomes of Cats With Ceruminoliths: A Retrospective Study of 31 Cases.","authors":"Mélanie Moreira André, Pascal Prélaud, Amaury Briand","doi":"10.1111/vde.70065","DOIUrl":"https://doi.org/10.1111/vde.70065","url":null,"abstract":"<p><strong>Background: </strong>Ceruminoliths are accumulations of cerumen and cornified material, in the ear canal that can obstruct the tympanic region (proximal external acoustic meatus). Management typically involves ceruminolytic agents or otic lavage under general anaesthesia.</p><p><strong>Hypothesis/objectives: </strong>To describe the clinical presentation, management and outcomes of cats diagnosed with ceruminoliths.</p><p><strong>Animals: </strong>Medical records of cats diagnosed between 2011 and 2024 were reviewed.</p><p><strong>Materials and methods: </strong>Inclusion criteria were visual confirmation of ceruminoliths by otoendoscopy, initiation of treatment and at least one follow-up examination. Treatment efficacy was assessed using otoendoscopy and an owner global assessment of treatment efficacy (OGATE).</p><p><strong>Results: </strong>Thirty-one cats were included; 26 underwent otoendoscopy-guided lavage under general anaesthesia combined with medical treatment, while five received medical treatment alone. Ceruminolytic cleaners and short-term systemic glucocorticoids (2-7 days) were commonly prescribed. Tympanic lesions were frequent, with perforation in 10 cats and thickening/discolouration in five. At final recheck, four cats had tympanic scarring or other irregularities, and one tympanic perforation persisted. At the initial follow-up, 55% of cats were free of ceruminoliths. At final follow-up, 65% remained recurrence-free. OGATE data were available for 15 owners: 60% reported a positive response, with five rating the outcome as excellent and four as good.</p><p><strong>Conclusions and clinical relevance: </strong>Tympanic lesions were frequent and sometimes permanent. The recurrence of ceruminoliths highlights the need to investigate underlying predisposing factors. This study emphasises the importance of recognising tympanic involvement and the necessity of long-term monitoring in affected cats.</p>","PeriodicalId":23599,"journal":{"name":"Veterinary dermatology","volume":" ","pages":""},"PeriodicalIF":1.4,"publicationDate":"2026-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147514929","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}