Veterinary dermatology最新文献

{"title":"Evaluation of oclacitinib maleate and prednisolone combined therapy for the control of atopic dermatitis in dogs: A controlled clinical trial.","authors":"Tássia Sell Ferreira, Wendy Roldán Villalobos, Vanessa Cunningham Gmyterco, Diogo Simões Fonseca, Marconi Rodrigues de Farias","doi":"10.1111/vde.13327","DOIUrl":"10.1111/vde.13327","url":null,"abstract":"<p><strong>Background: </strong>Canine atopic dermatitis (cAD) is a chronic inflammatory and pruritic dermatopathy requiring a multimodal therapeutic approach.</p><p><strong>Objective: </strong>To assess the effectiveness, safety and cost of oclacitinib and prednisolone treatment in dogs with AD.</p><p><strong>Animals: </strong>Twenty-three client-owned dogs with cAD.</p><p><strong>Materials and methods: </strong>Dogs were randomly assigned to one of two groups: Group 1 received prednisolone (0.5 mg/kg every 24 h) for 7 days, then oclacitinib (0.5 mg/kg) and prednisolone (0.5 mg/kg), were administered alternately with a 1 day pause between each drug, for 7 additional weeks. Group 2 received oclacitinib (0.5 mg/kg every 12 h for 14 days, then every 24 h) for 8 weeks. Assessments included the Canine Atopic Dermatitis Extent and Severity Index, 4th iteration (CADESI-04) and pruritus Visual Analog Scale (PVAS) on Day (D)0, D7, D14, D30, D45 and D60.</p><p><strong>Results: </strong>Both groups showed significant CADESI and PVAS reductions on D7 (p < 0.001). From D14 to D60, mean scores remained stable compared to D7, with no significant differences between groups. Adverse events included two dogs with polyuria and polydipsia, and three with polyphagia in Group 1, all of which resolved by D14. In Group 2, one dog experienced polyphagia, and two had self-limiting vomiting. Three dogs in Group 1 and one dog in Group 2 had mild increases in liver enzyme concentrations.</p><p><strong>Conclusions and clinical relevance: </strong>The combined protocol was effective and safe for managing itch and inflammation over a 60 day period. It had a 73.3% lower cost compared to oclacitinib alone.</p>","PeriodicalId":23599,"journal":{"name":"Veterinary dermatology","volume":" ","pages":"177-185"},"PeriodicalIF":1.9,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143081241","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of the in vitro antibiofilm activities of otic cleansers against canine otitis externa pathogens.","authors":"Bhumika F Savaliya, Sorae Kim, Tania Veltman, Darren J Trott","doi":"10.1111/vde.13331","DOIUrl":"10.1111/vde.13331","url":null,"abstract":"<p><strong>Background: </strong>Biofilm production by canine otitis externa (COE) pathogens and resistance development to multiple antimicrobials are commonly reported problems in veterinary practice. The use of adjuvants to disrupt biofilms may be a viable adjunctive therapy.</p><p><strong>Hypothesis/objectives: </strong>To compare the in vitro antibiofilm activity against COE pathogens of three otic cleansers: PHMB-EDTA (poly [hexamethylene] biguanide hydrochloride and disodium edetate), N-acetylcysteine (NAC) and Triz-EDTA.</p><p><strong>Animals/isolates: </strong>Thirty isolates of each species, including Staphylococcus pseudintermedius, Pseudomonas aeruginosa, Streptococcus canis, Proteus mirabilis, Escherichia coli, and Malassezia pachydermatis, were collected from COE cases and stored at -80°C until tested.</p><p><strong>Methods and materials: </strong>Biofilm production was determined by Congo-red agar and microtitre plate-assay methods. Ten of the best biofilm-producing isolates per species were selected to determine minimum biofilm eradication concentration (MBEC) values. Minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) values were determined to compare MBEC/MIC and MBEC/MBC.</p><p><strong>Results: </strong>PHMB-EDTA possessed antibiofilm activity at low concentrations (MBEC range 3.9/2.3-500/300 μg/mL) against all tested COE pathogens. NAC demonstrated antibiofilm activity for all tested bacterial COE pathogens (MBEC range 4,925-19,700 μg/mL); however, most M. pachydermatis isolates exhibited MBEC values >20,000 μg/mL. Triz/EDTA at the highest concentration tested (3,025/19,520 μg/mL) did not demonstrate antibiofilm activity against most COE pathogens except for S. canis (94.5/610 μg/mL).</p><p><strong>Conclusions and clinical relevance: </strong>PHMB-EDTA had intrinsic antibiofilm activity at low concentrations against all COE pathogens. Therefore, it is likely to be a very effective adjuvant when used in conjunction with other antimicrobials for the treatment of COE caused by biofilm-producing pathogens.</p>","PeriodicalId":23599,"journal":{"name":"Veterinary dermatology","volume":" ","pages":"148-158"},"PeriodicalIF":1.9,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11885093/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143459790","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative study of a commercial formula containing natural antimicrobials versus oral cephalexin or topical chlorhexidine-miconazole therapies for treating superficial pyoderma in dogs.","authors":"Vanessa Cunningham Gmyterco, Fernando Bittencourt Luciano, Lucas André Ludwig, Alberto Gonçalves Evangelista, Tássia Sell Ferreira, Fernanda Borek, Marconi Rodrigues de Farias","doi":"10.1111/vde.13323","DOIUrl":"10.1111/vde.13323","url":null,"abstract":"<p><strong>Background: </strong>Chronic and recurrent pyoderma in dogs is driving a growing interest in natural antimicrobial products that offer minimal adverse effects and avoid antibiotic resistance.</p><p><strong>Objectives: </strong>Evaluate the safety and efficacy of dermatological products with antimicrobial peptides and plant extracts, comparing them to chlorhexidine + miconazole and cephalexin therapy for superficial pyoderma in dogs.</p><p><strong>Materials and methods: </strong>Forty-five dogs with superficial pyoderma underwent clinical, cytopathological and microbiological diagnosis, and were randomly assigned to Group 1 (G1) treated with shampoo (two weekly baths) and lotion (twice daily on the affected areas) containing natural antimicrobials; Group 2 (G2) treated with two weekly baths using a therapeutic shampoo containing 2% chlorhexidine and 2.5% miconazole; or Group 3 (G3) treated with oral cephalexin 30 mg/kg twice daily. Staphylococcus spp. strains were identified using matrix-assisted laser desorption ionisation-time of flight mass spectrometry and pruritus Visual Analog Scale (PVAS)/lesion scores were evaluated on Day (D)0, D7, D14, D21 and D28.</p><p><strong>Results: </strong>Statistical differences (p < 0.05) were noted between D0 and D28 in PVAS values and lesion scores for all groups. G1 had lower PVAS scores than other groups on D7 and D14 (p < 0.05) and lower lesion scores than G3 on D7. By D28, G1 and G3 had lower lesion scores than G2. Notably, G1 and G2 had no adverse effects, while 26% of G3 patients experienced gastrointestinal issues during therapy.</p><p><strong>Conclusions and clinical relevance: </strong>This preliminary investigation of the new product (G1) suggests that it is effective, safe and a promising topical treatment for managing superficial pyoderma in dogs, offering an alternative to systemic antibiotics and topical antiseptic treatments.</p>","PeriodicalId":23599,"journal":{"name":"Veterinary dermatology","volume":" ","pages":"137-147"},"PeriodicalIF":1.9,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142955614","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A blinded randomised split-body clinical trial evaluating the effect of fluorescent light energy on antimicrobial management of canine interdigital furunculosis.","authors":"A Lange, U Mayer, E Bensignor, L Cornegliani, D Ferreira, I Matricoti, M Mosca, L Ordeix, D Pin, F Scarampella, E Videmont, A Yu, O Fantini","doi":"10.1111/vde.13340","DOIUrl":"https://doi.org/10.1111/vde.13340","url":null,"abstract":"<p><strong>Background: </strong>Canine interdigital furunculosis (CIF) is a complex, relapsing inflammatory condition, typically complicated by deep bacterial infections requiring prolonged systemic antibiotics.</p><p><strong>Hypothesis/objectives: </strong>This split-body study, where dogs acted as their own control, evaluated whether the adjunctive use of fluorescent light energy (FLE) could shorten the time to clinical resolution of CIF and minimise systemic antimicrobial use.</p><p><strong>Animals: </strong>Thirty-five client-owned dogs with signs of interdigital furunculosis in at least two paws.</p><p><strong>Materials and methods: </strong>This prospective, single-blinded, randomised, split-body multicentre clinical trial treated dogs with systemic antibiotics based on bacterial culture and sensitivity. One paw per dog was randomly selected using a coin-toss method for weekly FLE application, while the other paw served as a control. Dogs were scored every 2 weeks over 56 days on two parameters: a global lesion score (including haemorrhagic vesicles, fistulae with draining tracts, crusts and ulcers) and neutrophils engulfing bacteria score (NES, 0-4). Time to clinical resolution and lesion scores were assessed and compared between groups.</p><p><strong>Results: </strong>At Day (D)28 and D56, the FLE group showed significantly more healed paws (50% and 88%, p = 0.021) compared to the control (17% and 54%, p = 0.008). The median time to clinical resolution was shorter for the FLE group (35 days) compared to the control group (56 days, p = 0.017). No difference in NES score was observed between groups.</p><p><strong>Conclusions and clinical relevance: </strong>This blinded, randomised, split-body clinical trial demonstrated that FLE is an effective adjunctive therapy for CIF. It reduces the time to clinical resolution and increases the resolution rate while minimising the need for antibiotics.</p>","PeriodicalId":23599,"journal":{"name":"Veterinary dermatology","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143674577","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect on Staphylococcus species isolation from a 72-h transport delay of canine pyoderma samples to a microbiology laboratory.","authors":"L Tongen, N Heinrich, M Mcgilliard","doi":"10.1111/vde.13337","DOIUrl":"https://doi.org/10.1111/vde.13337","url":null,"abstract":"<p><strong>Background: </strong>The submission of bacterial cultures to an off-site microbiology laboratory is standard practice in veterinary medicine. The effects of a transport delay on culture results from canine pyoderma samples remain unknown.</p><p><strong>Hypothesis/objectives: </strong>The first objective was to evaluate the reliability of Staphylococcus species isolation by aerobic bacterial cultures from samples collected from canine pyoderma when transported to a microbiology laboratory on the collection day. The second objective was to evaluate the effect of a 72-h transport delay on Staphylococcus spp. isolation and antibiotic susceptibilities.</p><p><strong>Animals: </strong>Thirty client-owned dogs with pyoderma that presented to a private dermatology clinic were included in this study.</p><p><strong>Materials and methods: </strong>Three sterile culturettes were used to sequentially swab one pyoderma lesion per dog. Two samples were transported on the collection day (immediate cultures), while one was refrigerated for 72 h before transportation to a microbiology laboratory. Ninety cultures were performed and the results compared.</p><p><strong>Results: </strong>There was good reliability of Staphylococcus spp. isolation between the immediate cultures. There was no significant difference in the Staphylococcus spp. isolation, Staphylococcus spp. methicillin resistance or Staphylococcus pseudintermedius antibiotic susceptibilities with a 72-h transport delay, with the exception of chloramphenicol susceptibilities.</p><p><strong>Conclusions and clinical relevance: </strong>Cultures from canine pyoderma can have good reliability of Staphylococcus spp. isolation when submitted to a microbiology laboratory on the collection day. Cultures that are delayed at 4°C for ≤72 h can still have reliable results regarding S. pseudintermedius isolation and susceptibilities.</p>","PeriodicalId":23599,"journal":{"name":"Veterinary dermatology","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143664788","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Skin disease in sheep (Ovis aries): A retrospective report of 299 cases at a university veterinary medical teaching hospital (1986-2020).","authors":"Emma E Lauth, Stephen D White, Sarah M Depenbrock, Grace VanHoy, Meera C Heller, Munashe Chigerwe, Verena K Affolter","doi":"10.1111/vde.13338","DOIUrl":"https://doi.org/10.1111/vde.13338","url":null,"abstract":"<p><strong>Background: </strong>Skin diseases in sheep are important animal health and production problems, especially in wool-producing sheep.</p><p><strong>Hypothesis/objectives: </strong>To document the type, signalment, associations and prevalence of skin disease in a referral hospital population.</p><p><strong>Animals: </strong>Case population at a university veterinary medical teaching hospital.</p><p><strong>Materials and methods: </strong>Retrospective study by searching computerised medical records of sheep examined between 1 January 1986 and 1 January 2021.</p><p><strong>Keywords: </strong>'alopecia, Arcanobacterium pyogenes, Corynebacterium, Demodex, dermatitis, Dermatophilus, dermatophyte, ectoparasite, examination, fibre damage, foot rot, fungus, interdigital necrobacillosis, itching, lice, Malassezia, melanoma, mite, pruritus, rubbing, scabies, skin, SCC, squamous cell carcinoma, Staphylococcus, Trueperella pyogenes, wool break, wool loss'.</p><p><strong>Results: </strong>Two thousand and two records, totalling 11,799 sheep, had the age, breed and sex reported. Older sheep were more likely to present with skin disease (p < 0.0001; standard deviation 36.6 ± 1.15 confidence interval). The American Merino, East Friesian, Rambouillet, Suffolk and Shetland breeds were at higher risk of developing skin disease (p < 0.0001). Males, whether rams or wethers, were more likely to present with skin disease than ewes (p = 0.0019). Owing to the lack of dermatological examination reported, the four largest flocks (a total of 7,892 sheep) were excluded from disease analysis. Of the remaining 3,907 sheep, 299 (7.6%) had skin disease recorded. The most common diagnoses made were pododermatitis, bacterial abscesses, squamous cell carcinoma and myiasis. Fifty-five of 299 sheep were presented primarily for nonskin disease.</p><p><strong>Conclusions and clinical relevance: </strong>Clinicians should include a dermatological examination in sheep regardless of the reason for presentation.</p>","PeriodicalId":23599,"journal":{"name":"Veterinary dermatology","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-03-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143650232","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative efficacy of selenoureido carbonic anhydrase inhibitors and azole antifungal drugs against clinical isolates of Malassezia pachydermatis.","authors":"Costanza Spadini, Nicolò Mezzasalma, Amienwanlen Eugene Odigie, Andrea Angeli, Fabrizio Carta, Silvia Selleri, Emanuele Gandolfo, Simone Taddei, Valentina Franceschi, Sergio Minesso, Claudiu T Supuran, Clotilde Silvia Cabassi","doi":"10.1111/vde.13336","DOIUrl":"https://doi.org/10.1111/vde.13336","url":null,"abstract":"<p><strong>Background: </strong>Malassezia pachydermatis (MP) is implicated in severe dermatitis and otitis externa (OE) of companion animals and recently gained attention for its increasing resistance to azole compounds. For this reason, developing novel therapeutic strategies is of great interest. In a previous work, we used reference yeast isolates to evaluate several compounds bearing acyl/selenoureido moieties and primary/secondary sulfonamide groups for antifungal activity through organic selenium and carbonic anhydrase inhibition.</p><p><strong>Objectives: </strong>This work aimed to evaluate the antifungal efficacy of eight selenoureido compounds on 36 clinical MP isolates from dogs, compared to selected azoles, notably ketoconazole (KCZ), miconazole (MCZ) and fluconazole (FCZ).</p><p><strong>Materials and methods: </strong>MIC assays of 5g, 7a, 7c, 7k, 8c, 10c, 11b, 11f, KCZ, MCZ and FCZ were performed on 36 MP field isolates isolated from dogs affected by dermatitis and/or OE in which yeast aetiology was suspected. Minimum 50% and 90% inhibitory concentrations (MIC₅₀ and MIC₉₀) were calculated. MP identification was confirmed with a nested PCR for the internal transcribed spacer region of the rRNA gene.</p><p><strong>Results: </strong>Overall, the MIC₅₀ of the tested compounds on MP field isolates was higher than the MICs obtained on reference MP DSM 6172. Although KCZ showed the lowest MIC₅₀ value, compounds 5g, 7a and 7k showed lower MIC₅₀s than MCZ and FCZ. Five clinical isolates showed a MIC on azoles >MIC₉₀. Compounds 7a (four of five), 10c (three of five) and 8c (three of five) showed lower MIC values on these isolates compared to the tested azoles, suggesting good activity in phenotypically azole-resistant MP.</p><p><strong>Conclusions and clinical relevance: </strong>Considering the increasing azole resistance of the Malassezia genus, selenoureido compounds could represent a potential topical treatment for dog skin and ear mycotic infections.</p>","PeriodicalId":23599,"journal":{"name":"Veterinary dermatology","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-03-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143650230","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ozone water has antibacterial properties in dogs without skin barrier impairment.","authors":"Akira Matsuda, Tetsuya Ano, Yukari Nakamura, Takamasa Itoi, Kiyotaka Arai, Kenji Kutara, Keisuke Sugimoto, Noritaka Maeta","doi":"10.1111/vde.13339","DOIUrl":"https://doi.org/10.1111/vde.13339","url":null,"abstract":"<p><strong>Background: </strong>Recently, the use of disinfectants to treat bacterial skin diseases in dogs has garnered attention from the perspective of preventing the spread of antibiotic-resistant bacteria. Ozone water is a disinfectant that combines high antibacterial efficacy and safety; however, there have been no reports verifying its effects on skin barrier function in dogs.</p><p><strong>Objectives: </strong>This study aimed to verify the antibacterial properties and effects of ozone water on skin barrier function in dogs.</p><p><strong>Animals: </strong>Four beagles for the antibacterial test and six beagles for the barrier function test.</p><p><strong>Materials and methods: </strong>Purified water, 3 mg/L ozone water and 0.005% and 0.05% sodium hypochlorite were used as test products. Skin bacteria were collected 5 min after a single application of each and cultured to measure the bacterial counts. Trans-epidermal water loss (TEWL) and skin surface hydration (SSH) were measured before and after application once a day for 2 weeks. Additionally, the proliferation of canine epidermal keratinocytes (CPEK) was examined after a 5-min incubation with the test products.</p><p><strong>Results: </strong>Ozone water and 0.05% sodium hypochlorite significantly reduced the number of skin bacteria. None of the test products worsened TEWL and SSH values. Sodium hypochlorite completely inhibited the proliferation of CPEK, while ozone water did not.</p><p><strong>Conclusions and clinical relevance: </strong>Ozone water has an antibacterial effect on canine skin comparable to that of 0.05% sodium hypochlorite, but does not inhibit keratinocyte proliferation in vitro. Thus, ozone water has the potential to be used as a safe and effective disinfectant for canine skin.</p>","PeriodicalId":23599,"journal":{"name":"Veterinary dermatology","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143626329","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A retrospective, multicentric controlled study of the effect of specific allergen immunotherapy on medication needs in cats with atopic skin syndrome.","authors":"Thomas Brément, Emmanuel Bensignor, Emilie Vidémont Drevon-Gaillot, Maria-Dolores Sanchez, Sarah Pariente, Sébastien Viaud","doi":"10.1111/vde.13333","DOIUrl":"https://doi.org/10.1111/vde.13333","url":null,"abstract":"<p><strong>Background: </strong>Intradermal allergen testing (IDT) and allergen-specific immunotherapy (ASIT) remain underrated in feline dermatology.</p><p><strong>Hypothesis/objectives: </strong>The objectives of this retrospective study were to report the results of IDT and the effects of ASIT on the medication needs in a population of 158 cats diagnosed with feline atopic skin syndrome (FASS).</p><p><strong>Materials and methods: </strong>FASS was diagnosed after the exclusion of other pruritic conditions. IDT was performed under sedation/anaesthesia in 158 cats; in 136 of them, intravenous fluorescein and a Wood's lamp were used to facilitate interpretation. The medication scores were compared between cats with and without ASIT over a 1-year follow-up period.</p><p><strong>Results: </strong>IDT was interpretable in 153 cats (97%) of which no specific sensitisation could be detected in 53 cases (35%). Among the remaining 100 (65%) cats, polysensitisation and monosensitisation were observed in 78 and 22 cases, respectively. Cats were sensitised to house dust mites (HDM; 74%) including Dermatophagoides farinae (67%) and D. pteronyssinus (27%); storage mites (SM; 44%) including Tyrophagus putrescentiae (27%), Acarus siro (32%) and Lepidoglyphus destructor (8%); moulds (7%); grasses (18%); weeds (19%); tree pollens (19%); and fleas (17%). ASIT was initiated in 78 of 100 cats, and a 1-year follow-up period was available for 42. ASIT had no effect in 11 cats (26%). In the remaining 31 cats (74%), ASIT was associated with a significant reduction (≥ 30%) in medication scores.</p><p><strong>Conclusions and clinical relevance: </strong>ASIT is associated with a sparing effect in a significantly greater number of treated cats than untreated ones.</p>","PeriodicalId":23599,"journal":{"name":"Veterinary dermatology","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143606492","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Claw growth rates in a subset of adult, indoor, domestic cats (Felis catus).","authors":"Elena T Contreras, Kate Bruner, Courtney Hegwer, Andrew Simpson","doi":"10.1111/vde.13335","DOIUrl":"https://doi.org/10.1111/vde.13335","url":null,"abstract":"<p><strong>Background: </strong>Keratinised tissues, such as nails and claws, accumulate hormones over time; the claws' hormone concentrations are being explored as potential biomarkers. Timelines for hormone deposition can be established if claw growth rates are known. Hormone concentration within cat claws has been recently evaluated, yet the growth rates of cat claws remain unknown.</p><p><strong>Hypothesis/objectives: </strong>To estimate the growth rate of adult cats' claws, we hypothesised that front claw growth rates would differ from those of rear claws.</p><p><strong>Animals: </strong>Seventeen client-owned, indoor, neutered, adult cats.</p><p><strong>Materials and methods: </strong>Cats' claws were clipped and then measured lengthwise. Claws were repeatedly measured over time with repeat claw trims after approximately 1 month, followed by repeat measurements. Average claw growth rates were calculated for three digit groups: forelimb digit 1, forelimb digits 2-5 (front) and hind limb (rear). Growth rates of the front compared to the rear and digit 1 were compared through linear mixed effects regression modelling.</p><p><strong>Results: </strong>The daily mean claw growth rates were 0.13 mm for front and digit 1, and 0.08 mm for rear. The growth rate of rear claws was significantly lower (p < 0.001) than for front claws; rear claws grew, on average, 0.04 mm less per day than front claws.</p><p><strong>Conclusions and clinical relevance: </strong>Our study provides the first measurement of claw growth rates in cats. The significantly slower growth rate of rear claws compared to front claws should be considered when evaluating metabolites within cat claws.</p>","PeriodicalId":23599,"journal":{"name":"Veterinary dermatology","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143606493","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}