Veterinary dermatology最新文献

{"title":"Applying the Health Belief Model to Identify Factors Associated With Owner Persistence to Allergen-Specific Immunotherapy.","authors":"Caroline Williams, Alicia Webb Milum, Samantha Andritsch, Michael E von Fricken, Meagan Painter","doi":"10.1111/vde.70072","DOIUrl":"https://doi.org/10.1111/vde.70072","url":null,"abstract":"<p><strong>Background: </strong>Allergen-specific immunotherapy (ASIT) is the only treatment targeting the pathophysiology of canine atopic dermatitis (cAD) and feline atopic skin syndrome (FASS). Despite its disease-modifying potential, owner persistence remains a clinical challenge. This study applied the Health Belief Model (HBM) to evaluate factors influencing owner persistence with ASIT.</p><p><strong>Hypothesis/objectives: </strong>We hypothesised that owner perceptions of ASIT effectiveness, perceived barriers (e.g., cost) and ease of treatment integration would be associated with persistence. The objective was to identify modifiable psychological and logistical factors to support sustained ASIT use in cAD and FASS management.</p><p><strong>Animals: </strong>No animals were used.</p><p><strong>Materials and methods: </strong>Pets prescribed ASIT between 1 January 2020 and 31 May 2024, were identified from four geographically diverse veterinary dermatology practices. Owners completed a survey assessing HBM constructs-perceived susceptibility, perceived severity, perceived benefits, perceived barriers, self-efficacy, social support-and a knowledge domain. Owner-reported ASIT refill behaviour served as a proxy for persistence. Associations between HBM constructs and refill behaviour were evaluated using chi-square tests and logistic regression.</p><p><strong>Results: </strong>Higher perceived disease severity, greater perceived benefits and increased self-efficacy were positively associated with persistence. Owners who viewed their pet's condition as severe, believed ASIT effective, or felt confident administering treatment were more likely to continue therapy. Cost concerns and administration challenges were key perceived barriers.</p><p><strong>Conclusions and clinical relevance: </strong>This study highlights the psychological factors in owner persistence with ASIT. HBM-informed educational strategies that emphasise disease impact, treatment value and owner confidence may improve persistence with ASIT and long-term disease management.</p>","PeriodicalId":23599,"journal":{"name":"Veterinary dermatology","volume":" ","pages":""},"PeriodicalIF":1.4,"publicationDate":"2026-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147634259","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Epidemiology of Canine Cutaneous Histiocytoma: Insights From Age and Topographic Clustering.","authors":"C De Moura, K Pinello, J Catarino, J Niza-Ribeiro, J Santos, P Faísca","doi":"10.1111/vde.70068","DOIUrl":"https://doi.org/10.1111/vde.70068","url":null,"abstract":"<p><strong>Background: </strong>Canine cutaneous histiocytoma (CCH) is a benign Langerhans-cell tumour that often regresses spontaneously via inflammation.</p><p><strong>Objectives: </strong>To estimate incidence and characterise age and breed-anatomical-site patterns using two complementary clustering analyses.</p><p><strong>Materials and methods: </strong>A total of 359 histopathologically-confirmed CCHs from a private veterinary laboratory in Portugal (January 2020-January 2022) were analysed with dog-population denominators from the national registry (SIAC). Incidence rates (IR) were calculated for Lisbon-Setúbal; breed- and sex-specific relative risks (RR) were estimated. Age was modelled with BIC-selected Gaussian mixtures; breed-site patterns were summarised by hierarchical clustering of site frequencies (heatmaps).</p><p><strong>Results: </strong>Cases concentrated in young dogs (≤ 2 years, 48.8%) and males (58.5%). Age clustering defined three bands (≈ ≤ 1.5, 1.5-3.5, > 3.5 years) with differing breed and site distributions. Breed-site clustering revealed recurring anatomical predilections by breed and sex. The annual IR in Lisbon-Setúbal was 4.0 per 10,000 dogs (3.5 in females; 4.4 in males). Risk was highest in French bulldogs (RR 11.5; IR 34.1) and Boxers (RR 8.3; IR 24.5) versus mixed-breed dogs (p < 0.001).</p><p><strong>Conclusions and clinical relevance: </strong>Canine cutaneous histiocytoma (CCH) shows clear age bands and breed-linked anatomical predilections; these patterns help prioritise ages, sites and breeds for studies of inflammation-mediated regression.</p>","PeriodicalId":23599,"journal":{"name":"Veterinary dermatology","volume":" ","pages":""},"PeriodicalIF":1.4,"publicationDate":"2026-04-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147623363","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bacteriophage and Fusidic Acid Have Synergistic Effect Against Meticillin-Resistant Staphylococcus pseudintermedius in Ex Vivo Canine Dermis Model.","authors":"Sarah Ehling, Elisa Peh, Hilke Oltmanns, Jessica Meissner, Sophie Kittler, Christina Puff, Jutta Verspohl, Mathias Müsken, Madeleine Plötz, Andrea Vanessa Volk","doi":"10.1111/vde.70030","DOIUrl":"10.1111/vde.70030","url":null,"abstract":"<p><strong>Background: </strong>Antimicrobial stewardship has become vital given the progressive emergence of multidrug-resistant bacteria, and novel approaches to the treatment of bacterial infections are needed. Recently, reported synergistic effects of antibacterial drugs and bacteriophage therapy have revealed promising applications for the management of meticillin-resistant staphylococcal infections.</p><p><strong>Objectives: </strong>The objective of this study was to investigate the response of meticillin-resistant Staphylococcus pseudintermedius (MRSP) to treatment with a newly isolated, lytic MRSP-specific bacteriophage. Furthermore, a postulated synergism between phage and fusidic acid was examined in a canine ex vivo dermis model.</p><p><strong>Material and methods: </strong>Skin was harvested from the lateral thorax of a euthanised dog, clipped, the subcutis removed, and epidermis cleaved via a modified salt-split technique. The ex vivo dermis model established in Franz diffusion cells was inoculated with 1 × 10⁷ colony-forming units (cfu) of a clinical MRSP strain for 16 h. Then, experimental groups were treated with phage vB_SpsS_LmqsKl44-4 at a concentration of 2 × 10⁶ plaque-forming units and fusidic acid 0.4 mg alone or in combination for an additional 8 h.</p><p><strong>Results: </strong>Histopathological results showed that colonies of MRSP reached the superficial dermis and entered hair follicles. Co-treatment with fusidic acid and phage significantly reduced the amount of MRSP after 8 h.</p><p><strong>Conclusions and clinical relevance: </strong>In conclusion, topical co-treatment with fusidic acid and a phage could be a promising approach to the treatment of canine MRSP pyoderma.</p>","PeriodicalId":23599,"journal":{"name":"Veterinary dermatology","volume":" ","pages":"200-210"},"PeriodicalIF":1.4,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12967880/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145087570","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Treatment of Meticillin-Resistant Staphylococcus Pyoderma With Rifampicin in 104 Dogs: Clinical Outcomes, Adverse Effects, and Rifampicin Resistance in Nonresponders.","authors":"Tian Chee Lu, David Robson, Greg Burton","doi":"10.1111/vde.70032","DOIUrl":"10.1111/vde.70032","url":null,"abstract":"<p><strong>Background: </strong>Meticillin-resistant Staphylococcus pseudintermedius (MRSP) is often resistant to multiple antibiotics. Rifampicin is effective against most MRSP isolates, yet the potential for the development of rapid resistance raises questions regarding its suitability as an antibiotic monotherapy for MRSP pyoderma.</p><p><strong>Objectives: </strong>To describe the: (i) clinical outcome of rifampicin antibiotic monotherapy in MRSP pyoderma; (ii) frequency of adverse effects; and (iii) development of rifampicin resistance among dogs considered nonresponders to therapy.</p><p><strong>Materials and methods: </strong>A retrospective study of medical records from 1/1/2013 to 1/12/2022 of client-owned dogs with MRSP pyoderma treated with oral rifampicin as a systemic antibiotic monotherapy for 21 days.</p><p><strong>Results: </strong>104 dogs were included; 77 cases of superficial pyoderma (74%) and 27 cases of deep pyoderma (26%). The mean daily rifampicin dose was 6 mg/kg. Rifampicin was clinically effective in 86 cases (82.7%). Eleven of 18 nonresponding dogs demonstrated rapidly acquired rifampicin resistance (10.6%). Eighty-two (78.8%), 17 (16.3%), two (1.9%) and three (2.9%) dogs experienced zero, mild, moderate and severe adverse effects, respectively.</p><p><strong>Conclusions and clinical relevance: </strong>Rifampicin at 6 mg/kg is an effective and mostly well-tolerated monotherapy for treating MRSP pyoderma. However, in this study, it was associated with rapid development of resistance in ≥ 10% of treated dogs. Inadequate clinical response occurred without demonstrable resistance in 6.7% of cases. Concurrent use of ciclosporin or fluconazole with rifampicin increased the odds of severe adverse reactions.</p>","PeriodicalId":23599,"journal":{"name":"Veterinary dermatology","volume":" ","pages":"211-221"},"PeriodicalIF":1.4,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145378952","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnostic Value and Limitations of Dermoscopy in Humans and Animals: A Critical Comparative Analysis.","authors":"Noemi Plozner, Enzo Errichetti, Fabia Scarampella","doi":"10.1111/vde.70069","DOIUrl":"10.1111/vde.70069","url":null,"abstract":"<p><strong>Background: </strong>Dermoscopy is a noninvasive imaging technique that is well-established in human dermatology, where it enhances the diagnosis of neoplastic, inflammatory, infectious, and alopecic skin disorders. In veterinary dermatology, its use is expanding yet remains heterogeneous and largely descriptive, despite growing evidence of conserved dermoscopic patterns across species.</p><p><strong>Hypothesis/objectives: </strong>To review the applications of dermoscopy in veterinary dermatology, and to provide a comparative analysis of dermoscopic features observed in dogs, cats, and horses in relation to corresponding findings in human dermatology.</p><p><strong>Materials and methods: </strong>A systematic review of the literature reporting dermoscopic findings in veterinary dermatology was conducted in accordance with PRISMA guidelines. PubMed, Scopus and Google Scholar were searched for studies published up to 30 July 2025. Eligible studies included original articles describing dermoscopic features in dogs, cats, or horses. Extracted data included species, dermatological condition, dermoscopic findings, device type and histopathological correlation, when available. Levels of evidence were assessed using the Oxford Centre for Evidence-Based Medicine criteria.</p><p><strong>Results: </strong>Thirty studies met the inclusion criteria. Most were descriptive case reports or case series. Dermoscopy was applied to a wide range of conditions, including alopecias, parasitic infestations, dermatophytosis, neoplastic and sebaceous lesions, inflammatory dermatoses, and congenital vascular anomalies. Recurrent dermoscopic features showed strong similarities to those described in human dermatology, although species-specific anatomical differences influenced interpretation.</p><p><strong>Conclusions: </strong>Dermoscopy represents a valuable adjunct diagnostic tool in veterinary dermatology, with clear translational relevance. Standardisation of terminology and further prospective studies are required to support its broader clinical integration.</p>","PeriodicalId":23599,"journal":{"name":"Veterinary dermatology","volume":" ","pages":""},"PeriodicalIF":1.4,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147594690","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Novel Topical Emollient Plus for Canine Atopic Dermatitis: A Clinical Trial Assessing Efficacy and User Acceptance.","authors":"Beatriz Fernandes, António Caldeira Mendes, Susana Paula Alves, Vanessa Schmidt, Ana Filipa Bizarro, Marta Pinto, Hugo Pereira, Joana Marto, Ana Mafalda Lourenço","doi":"10.1111/vde.70035","DOIUrl":"10.1111/vde.70035","url":null,"abstract":"<p><strong>Background: </strong>Canine atopic dermatitis (cAD) is a common, chronic skin condition characterised by epidermal barrier dysfunction, immune dysregulation and cutaneous dysbiosis. While 'emollient plus' formulations are widely used in human atopic dermatitis (hAD), their role in cAD remains underexplored.</p><p><strong>Hypothesis/objectives: </strong>To evaluate the clinical efficacy and owner-perceived value of a novel emollient plus formulation as a co-adjuvant treatment for cAD.</p><p><strong>Animals: </strong>Twenty-one client-owned dogs with controlled, nonseasonal cAD completed the study.</p><p><strong>Materials and methods: </strong>A proof-of-concept, bench-to-bedside study was conducted over 30 days. Dogs received a once-daily application of a novel emollient plus formulation developed in-house. Clinical outcomes were assessed using pruritus Visual Analog Scale (pVAS)10 and Canine Atopic Dermatitis Extent and Severity Index (CADESI)-04 scores, alongside skin barrier function parameters (trans epidermal water loss [TEWL] and pH) at the pinnae and inguinal areas. Owners evaluated therapeutic efficacy via the Owner Global Assessment of Treatment Efficacy (OGATE) questionnaire and sensorial acceptability through a survey.</p><p><strong>Results: </strong>Significant reductions were observed in pVAS10 (4.25 ± 1.85 to 3.38 ± 1.79; p = 0.016) and CADESI-04 (24.62 ± 18.48 to 13.43 ± 7.44; p = 0.02) scores. TEWL (18.63 ± 17.33 to 9.56 ± 10.75; p = 0.049) and pH (6.07 ± 0.97 to 5.41 ± 0.71; p = 0.01) only had significant reductions at the pinnae. Owner satisfaction was exceptionally high, with 90.47% rating treatment efficacy as 'good to excellent'. The sensorial properties of the formulation also received consistently positive ratings.</p><p><strong>Conclusions and clinical relevance: </strong>This cAD-targeted emollient product demonstrated promising efficacy in reducing pruritus and skin lesions while possibly improving skin barrier function. Its favourable safety profile and high owner satisfaction suggest strong potential for routine clinical use in the management of cAD. Further controlled studies are warranted to confirm efficacy and optimised treatment protocols.</p>","PeriodicalId":23599,"journal":{"name":"Veterinary dermatology","volume":" ","pages":"293-305"},"PeriodicalIF":1.4,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12967881/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145453289","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of Epidermal Growth Factor on Tympanic Membrane Epithelial Migration in Canine Models.","authors":"Yujin Lee, Seulgi Bae","doi":"10.1111/vde.70038","DOIUrl":"10.1111/vde.70038","url":null,"abstract":"<p><strong>Background: </strong>Tympanic membrane epithelial migration (TMEM) protects the external ear canal from infections and aids in the removal of keratin. Epidermal growth factor (EGF) accelerates tissue regeneration by stimulating cell proliferation and migration.</p><p><strong>Hypothesis/objectives: </strong>Topical application of EGF will accelerate the canine TMEM rate.</p><p><strong>Animals: </strong>Three male beagle dogs.</p><p><strong>Materials and methods: </strong>Six TMs were divided into control and experimental phases. The experimental phase was assessed 2 weeks after the control phase and involved weekly EGF applications (0.5 mg/mL; 25 μg in 50 μL of phosphate-buffered saline), while the control phase involved no treatment. TMEM was assessed by applying ink spots to the TM and tracking migration on Day (D)0, D7, D14 and D21. A paired Student's t-test was used to compare the daily TMEM rates between phases.</p><p><strong>Results: </strong>The EGF-treated phase had a significantly higher mean TMEM rate (235.0 ± 91.76 μm/day) than the control phase (146.83 ± 69.95 μm/day), showing a 60.1% increase (p < 0.05). The mean difference was 88.2 μm/day (95% confidence interval [CI]: 36.8-139.5). This difference was statistically significant based on both the paired t-test (p = 0.020) and Wilcoxon signed-rank test (p = 0.031). No differences were noted between the left and right ears, and no adverse effects occurred.</p><p><strong>Conclusions and clinical relevance: </strong>These results suggest that EGF increases TMEM in dogs. These initial findings suggest potential clinical applications of EGF. Further studies are needed to validate these findings and evaluate their therapeutic potential.</p>","PeriodicalId":23599,"journal":{"name":"Veterinary dermatology","volume":" ","pages":"269-273"},"PeriodicalIF":1.4,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145606176","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Machine Learning Model for an App-Based Tool to Assist With the Diagnosis of Canine Atopic Dermatitis.","authors":"Xavier Langon, Mathieu Montoya, Isabelle Gourdon","doi":"10.1111/vde.70031","DOIUrl":"10.1111/vde.70031","url":null,"abstract":"<p><strong>Background: </strong>Canine atopic dermatitis (cAD) is a chronic condition requiring life-long management. Accurate diagnosis can be challenging, with no reliable diagnostic test.</p><p><strong>Objectives: </strong>This study aimed to generate a simple diagnostic model for cAD.</p><p><strong>Materials and methods: </strong>Machine learning by Random Forest was applied to metadata from a prospective dataset of clinical cases definitively diagnosed with cAD alone or another dermatosis. The dataset underwent a division of 67% for training and 33% for testing, with the model being trained via stratified K-fold cross-validation on the former portion, while performance assessment was conducted on the latter portion. Nine referral clinicians across four European countries contributed 645 cases.</p><p><strong>Results: </strong>Modelling confirmed the value of the four tested metadata on a dog's history and reduced the initial 15 lesion locations tested to three. Metadata for the final model were: predisposed breed (any from a list of 31), predominantly indoor life, dermatitis onset age between 6 months and 3 years, dermatitis chronic, recurrent or a permanent background. Lesion locations were axilla, inguinal and other. Diagnostic prediction was 95% sensitive and 84% specific.</p><p><strong>Conclusions and clinical relevance: </strong>This model is a relevant prototype for an app-based tool to support general practitioners in the diagnosis of cAD alongside existing tests. It has high sensitivity and specificity based on four questions and three lesion locations obtained from a standard history and clinical examination.</p>","PeriodicalId":23599,"journal":{"name":"Veterinary dermatology","volume":" ","pages":"236-246"},"PeriodicalIF":1.4,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12967876/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145186831","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Use of a Cytobrush for Sampling the Ear Canal of Dogs With Otitis Externa.","authors":"Nicoly Radaeli Atanasio, Gabriela Reis Ledur, Danilo Marcondes Filho, Daniel Guimarães Gerardi","doi":"10.1111/vde.70036","DOIUrl":"10.1111/vde.70036","url":null,"abstract":"<p><strong>Background: </strong>Cytological examination of the ear canal is essential for evaluating dogs with otitis externa (OE). The conventional sampling method uses a swab. However, the cytobrush (gynaecological cervical brush), already used for cytological collection from other anatomical sites, has not been adequately investigated for this purpose in dogs with OE.</p><p><strong>Objectives: </strong>To compare the cytobrush as a sampling tool for the ear canal of dogs with OE and compare it with the swab technique.</p><p><strong>Animals: </strong>Thirty ears from 17 dogs with OE, presented at a veterinary teaching hospital, were included for sampling.</p><p><strong>Materials and methods: </strong>Cytological samples were collected using both a cytobrush and a swab in random order. Two independent and blinded evaluators quantified micro-organisms (cocci, bacilli, yeasts), mononuclear cells, polymorphonuclear cells and epithelial cells. Animal discomfort during sampling was assessed using a scoring system.</p><p><strong>Results: </strong>No significant differences were found between the methods regarding the presence of micro-organisms or inflammatory and epithelial cells (p > 0.05), indicating equivalence between techniques. The intraclass correlation coefficient (ICC > 0.9) demonstrated high reproducibility between evaluators. Although the oto-podal reflex was more frequent with the cytobrush, it did not significantly impact overall animal discomfort.</p><p><strong>Conclusions and clinical relevance: </strong>The cytobrush is an effective, safe and well-tolerated sampling method, and may be considered a viable alternative to the swab for collecting samples from the ear canal of dogs with OE.</p>","PeriodicalId":23599,"journal":{"name":"Veterinary dermatology","volume":" ","pages":"227-235"},"PeriodicalIF":1.4,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12967878/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145482863","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Randomised, Double-Blinded, Placebo-Controlled Challenge Test With Single Food Items in Dogs With Atopic Dermatitis and Adverse Food Reactions.","authors":"Evi I Sofou, Elisa Samuel, Svetlina Aleksandrova, Manolis Chatzis, Manolis N Saridomichelakis","doi":"10.1111/vde.70041","DOIUrl":"10.1111/vde.70041","url":null,"abstract":"<p><strong>Background: </strong>Identification of offending foods in dogs with adverse food reactions is usually based on \"deterioration\" during open food challenges.</p><p><strong>Objectives: </strong>To examine the placebo effect during double-blinded, placebo-controlled food challenges using a predefined set of criteria for relapse.</p><p><strong>Animals: </strong>Twelve dogs with atopic dermatitis and adverse food reactions.</p><p><strong>Materials and methods: </strong>Dogs were serially challenged with 40 g/day of eight food items (beef, chicken, codfish, corn flour, cow's milk, hen's egg, lamb, wheat), for 1 week, each mixed with their elimination diet and water. An additional two challenges were placebo (elimination diet mixed with water). Owners and investigators were blinded to the challenges and the order of the 10 challenges was randomised for each dog. Relapse was defined as moderate-to-severe owner global assessment of challenge deterioration and/or > 100% increase of Canine Atopic Dermatitis Extent and Severity Index, 4th iteration (CADESI-04) score (with the score at the end being > 9) and/or > 100% increase of pruritus using a Visual Analog Scale (with the score at the end being > 1.9/10).</p><p><strong>Results: </strong>Most (91.7%) dogs were positive to one to six challenges with food items, yet half of them also were falsely positive in one placebo challenge. Two dogs had only one placebo challenge. The number of positive challenges to foods did not differ between dogs with positive and negative placebo challenges.</p><p><strong>Conclusions and clinical relevance: </strong>The placebo effect during double-blinded food challenges creates doubts about the accuracy of the results of challenges with food items in this and in previous studies where open food challenges were used.</p>","PeriodicalId":23599,"journal":{"name":"Veterinary dermatology","volume":" ","pages":"247-256"},"PeriodicalIF":1.4,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12967879/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145678703","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}