Veterinary dermatology最新文献

Probiotic Engraftment and Suppression of Canine Otitis Externa Pathogens by Probiotic Ear Drops. 益生菌滴耳液对犬中耳炎外源性病原菌的抑制作用。

IF 1.4 3区农林科学

Veterinary dermatology Pub Date : 2026-05-08 DOI: 10.1111/vde.70080

Marta Salichs, Shea Beasley, Hanne Gagroo, Alix Simons, Tim Henkens, Josep Homedes, Ingmar Claes

{"title":"Probiotic Engraftment and Suppression of Canine Otitis Externa Pathogens by Probiotic Ear Drops.","authors":"Marta Salichs, Shea Beasley, Hanne Gagroo, Alix Simons, Tim Henkens, Josep Homedes, Ingmar Claes","doi":"10.1111/vde.70080","DOIUrl":"https://doi.org/10.1111/vde.70080","url":null,"abstract":"Background: Lactobacillaceae have shown promise with their potential to outcompete pathogens and restore a healthy microbial balance in otitis externa (OE).Hypothesis/objectives: This study aimed to evaluate the presence of viable Lactobacillaceae over time and in vitro ability to inhibit growth of common OE pathogens.Animals: Fifteen healthy dogs were enrolled and randomised into five groups (n = 3 per group) to receive six probiotic ear drops containing live Lactiplantibacillus plantarum YUN-V2.0 and Lacticaseibacillus rhamnosus YUN-S1.0.Materials and methods: Ear swabs were taken 24, 48, 72, 96 h and 7 days post single application for culturing. For pathogen inhibition, clinical isolates of Pseudomonas aeruginosa, Staphylococcus pseudintermedius and Malassezia pachydermatis were tested against the probiotic ear drop and antimicrobial disks of florfenicol 30 μg, gentamicin 30 μg, marbofloxacin 5 μg, miconazole 10 μg, neomycin 120 μg and terbinafine 1.5 μg.Results: A relatively basal low abundance of commensal and Lactobacillaceae micro-organisms was detected (1.34 × 103 colony-forming units [cfu]/mL). At 24 h post-application, Lactobacillaceae increased significantly (2.3 × 106 cfu/mL; p < 0.001), and remained above 105 cfu/mL at 1 week post-application (1.6 × 105 cfu/mL). Lactobacilli demonstrated better growth inhibition of P. aeruginosa than gentamicin and marbofloxacin, and of S. pseudintermedius than gentamicin, neomycin and marbofloxacin. For M. pachydermatis similar growth inhibition versus miconazole and terbinafine was observed.Conclusions and clinical relevance: These results suggest that probiotic strains exhibit excellent retention and can inhibit the growth of S. pseudintermedius, P. aeruginosa, and M. pachydermatis.","PeriodicalId":23599,"journal":{"name":"Veterinary dermatology","volume":" ","pages":""},"PeriodicalIF":1.4,"publicationDate":"2026-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147857173","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Case of Slow Progressive Cutaneous Angiomatosis on a Cat Metatarsal Pad Treated by a Topical Beta-Blocker. 局部β受体阻滞剂治疗猫跖垫缓慢进展性皮肤血管瘤病一例。

IF 1.4 3区农林科学

Veterinary dermatology Pub Date : 2026-05-05 DOI: 10.1111/vde.70079

Adrien Accard, Rita Bitar, Maria Dolores Sanchez, Philippe Blumstein, Olivier Albaric, Nora Bouhsina, Emmanuel Bensignor

引用次数: 0

Effect of Fluorescence Photobiomodulation on Canine Progenitor Epidermal Keratinocytes With and Without Staphylococcus pseudintermedius Colonisation. 荧光光生物调节对犬祖细胞表皮角质形成细胞的影响。

IF 1.4 3区农林科学

Veterinary dermatology Pub Date : 2026-05-04 DOI: 10.1111/vde.70076

Annette T Lundberg, Amelia White, Linda Archer, Domenico Santoro

{"title":"Effect of Fluorescence Photobiomodulation on Canine Progenitor Epidermal Keratinocytes With and Without Staphylococcus pseudintermedius Colonisation.","authors":"Annette T Lundberg, Amelia White, Linda Archer, Domenico Santoro","doi":"10.1111/vde.70076","DOIUrl":"https://doi.org/10.1111/vde.70076","url":null,"abstract":"Background: Fluorescence photobiomodulation (FPB) is a treatment for canine dermatitis, yet no studies exist assessing its effect on canine keratinocytes in vitro.Objectives: To determine: (i) the anti-inflammatory and antimicrobial effect of FPB on canine progenitor epidermal keratinocytes (CPEK) with and without colonisation by Staphylococcus pseudintermedius (SP); (ii) changes in CPEK viability following FPB exposure; and (iii) SP colony count following FPB exposure.Materials and methods: Keratinocytes were grown in chamber slides, with and without SP, and treated with two, 2 min exposures to FPB. Supernatant was collected at 0, 1, 6, and 24 h post-FPB to evaluate cytokines (interleukin [IL]-2, IL-6, IL-7, IL-8, IL-10, IL-15, IL-18, interferon-γ induced protein 10 [IP-10], tumour necrosis factor-α, interferon-γ, keratinocyte chemotactic-like, granulocyte-macrophage colony-stimulating factor, and monocyte chemoattractant protein-1), and host defence peptides (β-defensin 3-like and cathelicidin) secretion. Cell cytotoxicity was assessed via lactate dehydrogenase and adenosine triphosphate assays. The supernatant pellet was collected at 0 and 24 h, resuspended, and plated. Bacterial colonies were counted after 24 h of incubation. Experiments were performed in duplicate and repeated five times.Results: At 6 h post-FPB, IP-10 fluorescence intensity was mildly yet significantly decreased in CPEK+SP (p = 0.04). No other statistically significant differences were found for cytokine, β-defensin, cathelicidin, or SP colony counts. A lack of cytotoxicity was observed post-FPB over a 24 h period.Conclusions and clinical relevance: Fluorescence photobiomodulation may have a mild anti-inflammatory effect on CPEKs colonised by SP in vitro based on the significant decrease in IP-10 production 6 h post-FBP exposure, yet does not affect CPEK cell viability.","PeriodicalId":23599,"journal":{"name":"Veterinary dermatology","volume":" ","pages":""},"PeriodicalIF":1.4,"publicationDate":"2026-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147843484","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Immunohistochemical Evaluation of TLR-4, HSP-70 and Caspase-3 Expressions in Lesional Areas of Ecthyma Disease. TLR-4、HSP-70和Caspase-3在湿疹病变区表达的免疫组化评价

IF 1.4 3区农林科学

Veterinary dermatology Pub Date : 2026-05-02 DOI: 10.1111/vde.70082

Emine Nur Dincer, Ozlem Ozmen

{"title":"Immunohistochemical Evaluation of TLR-4, HSP-70 and Caspase-3 Expressions in Lesional Areas of Ecthyma Disease.","authors":"Emine Nur Dincer, Ozlem Ozmen","doi":"10.1111/vde.70082","DOIUrl":"https://doi.org/10.1111/vde.70082","url":null,"abstract":"Background: Contagious ecthyma (Orf) is a highly contagious, economically significant disease affecting sheep, goats and wild small ruminants, caused by the resilient Orf virus (ORFV). It produces thick, crusted lesions around the mouth and nostrils, especially in animals aged 3-4 months, sometimes causing near 100% mortality in immunocompromised young animals. ORFV targets epithelial cells, evading host defences and impairing feeding, which leads to malnutrition and production losses. Key molecules such as Toll-like receptor (TLR)-4, heat shock protein (HSP)-70 and caspase-3 play crucial roles in innate immunity, stress responses and apoptosis.Objectives: This study investigates TLR-4, HSP-70 and caspase-3 expression in the lesions of naturally infected animals.Materials and methods: A total of 37 ecthyma lesions were examined histopathologically and immunohistochemically.Conclusions and clinical relevance: All three markers showed increased expression in both epithelial cells and inflammatory infiltrates within the lesions. These findings indicate that TLR-4, HSP-70 and caspase-3 may play pivotal roles in the immunopathogenesis of contagious ecthyma and could represent potential diagnostic or therapeutic targets. Further research is warranted to clarify their mechanistic involvement and potential applications in disease control strategies.","PeriodicalId":23599,"journal":{"name":"Veterinary dermatology","volume":" ","pages":""},"PeriodicalIF":1.4,"publicationDate":"2026-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147821340","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Artificial Intelligence-Based Identification of Common Canine Skin Lesions From Clinical Images. 基于人工智能的犬类常见皮肤病变临床图像识别

IF 1.4 3区农林科学

Veterinary dermatology Pub Date : 2026-05-01 DOI: 10.1111/vde.70083

Soh-Yoon Kang, Yeong-Hun Kang, Hyun-Jung Kim, Eun-A Huh, Jong-Soo Jeon, Hyun-Su Kim, Min-Sun Kim, Anisha Tiwari, Cheol-Yong Hwang

{"title":"Artificial Intelligence-Based Identification of Common Canine Skin Lesions From Clinical Images.","authors":"Soh-Yoon Kang, Yeong-Hun Kang, Hyun-Jung Kim, Eun-A Huh, Jong-Soo Jeon, Hyun-Su Kim, Min-Sun Kim, Anisha Tiwari, Cheol-Yong Hwang","doi":"10.1111/vde.70083","DOIUrl":"https://doi.org/10.1111/vde.70083","url":null,"abstract":"Background: Accurate evaluation of skin lesions is an essential component of dermatological examination, yet it can be time-consuming and subject to interobserver variability. While artificial intelligence (AI) models have shown reliability in diagnosing specific skin diseases, lesion-level identification remains underexplored in veterinary dermatology.Objectives: To develop and evaluate a convolutional neural network (CNN)-based AI model for the automated identification of four skin lesion types in dogs: erythema, lichenification, alopecia and erosion/ulcer.Animals: Clinical skin images were collected from dogs presented to a veterinary medical teaching hospital.Materials and methods: Four EfficientNet models were independently trained, one for each lesion type. Model performance was evaluated by comparing the prediction results with veterinary surgeon-labelled data, using six metrics: accuracy, sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV) and F1 score.Results: All four CNN models achieved an accuracy of > 90%, indicating a reliable performance across all lesion types. The alopecia model yielded the highest accuracy (98.12%) and F1 score (98.18%). The erythema and erosion/ulcer models exhibited balanced performance across all metrics. For the lichenification model, the sensitivity (87.02%) and F1 score (89.88%) were the lowest among the four lesion types.Conclusions and clinical relevance: The CNN-based AI models developed in this study demonstrated validity in identifying common canine skin lesions from clinical images. These models may facilitate rapid and objective dermatological evaluation, supporting clinical diagnosis and lesion monitoring throughout treatment.","PeriodicalId":23599,"journal":{"name":"Veterinary dermatology","volume":" ","pages":""},"PeriodicalIF":1.4,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147821363","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cutaneous Invasive Opportunistic Fungal Infections in Dogs Receiving Ciclosporin for Immune-Mediated Diseases: A Case-Control Study. 接受环孢素治疗免疫介导疾病犬皮肤侵袭性机会性真菌感染：一项病例对照研究

IF 1.4 3区农林科学

Veterinary dermatology Pub Date : 2026-04-27 DOI: 10.1111/vde.70075

Paola Orlandini, Erika Carli, Laura Ventura, Patrizia Danesi, Laura Berto, Carolina Mendes, Michela De Lucia

{"title":"Cutaneous Invasive Opportunistic Fungal Infections in Dogs Receiving Ciclosporin for Immune-Mediated Diseases: A Case-Control Study.","authors":"Paola Orlandini, Erika Carli, Laura Ventura, Patrizia Danesi, Laura Berto, Carolina Mendes, Michela De Lucia","doi":"10.1111/vde.70075","DOIUrl":"https://doi.org/10.1111/vde.70075","url":null,"abstract":"Background: Cutaneous opportunistic invasive fungal infections (OIFIs) are mainly reported in immunosuppressed dogs, especially those receiving ciclosporin (CsA). Studies investigating factors other than CsA that favour cutaneous OIFIs in dogs are lacking.Hypothesis/objectives: To identify host factors, clinicopathological data, and therapeutic regimens associated with the development of cutaneous OIFIs in dogs receiving CsA for immune-mediated diseases.Animals: Client-owned dogs treated with CsA, with or without systemic glucocorticoids (GCs) for various immune-mediated diseases. Dogs were classified as cases if they had developed cutaneous OIFIs during CsA treatment, or as controls if they had not.Materials and methods: Cases and controls were matched based on the immune-mediated disease and the duration of CsA treatment. Signalment, anamnestic and pertinent clinical data as well as selected laboratory parameters, including blood cell count, neutrophil-to-lymphocyte ratio (NLR), neutrophil-to-monocyte ratio (NMR), C-reactive protein, haptoglobin, total globulins and immunoglobulin (Ig)G and IgM serum levels, were retrospectively collected and analysed.Results: Eight OIFI-affected dogs were matched with 20 control dogs. Among the examined variables, only higher neutrophil count and neutrophil ratios (NLR, NMR) were significantly associated with cutaneous OIFIs.Conclusions and clinical relevance: No significant associations were observed between host factors, treatment regimens, and OIFI development in dogs receiving CsA. Further research is needed to clarify the role of GCs and to evaluate NLR and NMR as monitoring tools in immunosuppressed dogs.","PeriodicalId":23599,"journal":{"name":"Veterinary dermatology","volume":" ","pages":""},"PeriodicalIF":1.4,"publicationDate":"2026-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147782575","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Case of Suspected Congenital Hypothyroidism Causing Generalised Alopecia in a Wombat (Lasiorhinus latifrons). 怀疑先天性甲状腺功能减退症导致袋熊（Lasiorhinus latifrons）全身脱发1例。

IF 1.4 3区农林科学

Veterinary dermatology Pub Date : 2026-04-27 DOI: 10.1111/vde.70074

Amelia Sy Ho, Meng K Siak

引用次数: 0

Treatment of Canine Pemphigus Foliaceus, Pemphigus Vulgaris and Mucous Membrane Pemphigoid With Oclacitinib: A Retrospective Analysis of 21 Cases. 奥拉西替尼治疗犬叶状天疱疮、寻常型天疱疮和粘膜类天疱疮21例回顾性分析。

IF 1.4 3区农林科学

Veterinary dermatology Pub Date : 2026-04-26 DOI: 10.1111/vde.70078

Breanna L Scranton, Lara M Tomich, Andrea T H Lam, Verena K Affolter, Catherine A Outerbridge

{"title":"Treatment of Canine Pemphigus Foliaceus, Pemphigus Vulgaris and Mucous Membrane Pemphigoid With Oclacitinib: A Retrospective Analysis of 21 Cases.","authors":"Breanna L Scranton, Lara M Tomich, Andrea T H Lam, Verena K Affolter, Catherine A Outerbridge","doi":"10.1111/vde.70078","DOIUrl":"https://doi.org/10.1111/vde.70078","url":null,"abstract":"Background: This study was performed to retrospectively evaluate the efficacy of oclacitinib (OC) (Apoquel; Zoetis) as a treatment option for pemphigus foliaceus (PF), pemphigus vulgaris (PV) and mucous membrane pemphigoid (MMP).Objective: To determine if OC can reduce or replace the corticosteroid use in dogs with PF, PV and MMP.Animals: There were no animal subjects.Procedure: Multicentre retrospective study reviewing medical records from two institutions for dogs diagnosed with PF, PV or MMP and prescribed OC between 2014 and 2025.Results: Twenty-one dogs diagnosed with PF, PV or MMP via histopathological results were included. OC alone was effective in eight of 18 PF dogs at a median dose of 0.65 mg/kg/day per os (range 0.5-1.9 mg/kg/day p.o.). Five dogs reached clinical remission, and three reached partial remission. One PV dog and the MMP dog each reached clinical remission with OC alone at 0.7 mg/kg/day and 0.24 mg/kg every other day, respectively. OC was a corticosteroid-sparing agent or adjunctive therapy in seven of 18 PF dogs at a median dose of 0.6 mg/kg/day (range 0.4-2.4 mg/kg/day). One PV dog reached partial remission at OC 1.9 mg/kg/day and prednisone 1.8 mg/kg/day yet died from pancreatitis. OC was ineffective in three of 18 PF dogs at a median dose of 1.0 mg/kg/day p.o. (range 0.9-1.2 mg/kg/day p.o.). Statistical significance was not analysed.Conclusions and clinical relevance: OC is an effective sole therapeutic agent or adjunctive therapy in a subset of dogs with PF, PV or MMP. The long-term safety of higher doses of OC is unknown.","PeriodicalId":23599,"journal":{"name":"Veterinary dermatology","volume":" ","pages":""},"PeriodicalIF":1.4,"publicationDate":"2026-04-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147782650","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Retrospective Case Series Reporting the Clinical Efficacy and Adverse Events of Oclacitinib Administration for Skin Disease in 238 Cats. 238只猫使用奥克拉替尼治疗皮肤病的临床疗效和不良事件回顾性分析

IF 1.4 3区农林科学

Veterinary dermatology Pub Date : 2026-04-26 DOI: 10.1111/vde.70077

Marlyse R Wehber, Melissa C Eisenschenk, Amanda J Young, Sandra N Koch

{"title":"A Retrospective Case Series Reporting the Clinical Efficacy and Adverse Events of Oclacitinib Administration for Skin Disease in 238 Cats.","authors":"Marlyse R Wehber, Melissa C Eisenschenk, Amanda J Young, Sandra N Koch","doi":"10.1111/vde.70077","DOIUrl":"https://doi.org/10.1111/vde.70077","url":null,"abstract":"Background: Off-label oclacitinib use for feline dermatoses management is increasing despite the paucity of data regarding optimal dose and adverse events (AEs).Objective: Review AEs, clinical efficacy, and dose regimens in cats prescribed oclacitinib.Materials and methods: Retrospective case series of 238 privately owned cats prescribed oclacitinib for dermatological disease. Signalment, history, laboratory abnormalities, oclacitinib dosage (mg/kg/day), treatment duration and AEs using a modified Naranjo Adverse Drug Reaction Probability Scale were retrieved from medical records spanning August 2014 to May 2024. Clinical efficacy was estimated using a pruritus Visual Analogue Scale and medical record lesional descriptions; categorised as complete, partial or no response.Results: The mean (x̄) initial dosage prescribed was 1.89 mg/kg/day. Monotherapy controlled clinical signs in 140 of 238 cats (59%), including 83 of 140 cats (59%) on twice daily (x̄ = 1.85 mg/kg/day) and 57 of 140 cats (41%) on once daily administration (x̄ = 1.05 mg/kg/day). The median treatment duration was 271.5 days (range 1 day-7.5 years). Main diagnoses successfully managed included feline atopic skin syndrome (61%) and pemphigus foliaceus (29%). Thirty-three 'definite' or 'probable' AEs were observed in 32 of 238 cats including: neutropaenia 6.3% (n = 15), gastrointestinal 4% (n = 9), lethargy 1.7% (n = 4), infection 0.8% (n = 2), hyperactivity 0.4% (n = 1), elevated alanine transaminase 0.4% (n = 1) and elevated creatinine 0.4% (n = 1).Conclusions and clinical relevance: Off-label oclacitinib administration in cats appeared to be well-tolerated and effective with AEs typically mild, responsive to dose reduction, and similar to those reported in dogs.","PeriodicalId":23599,"journal":{"name":"Veterinary dermatology","volume":" ","pages":""},"PeriodicalIF":1.4,"publicationDate":"2026-04-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147782597","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Long-Term Use of Oclacitinib Maleate for the Management of Pemphigus Foliaceus in a Miniature Donkey. 长期应用马来酸奥拉西替尼治疗小型驴叶性天疱疮。

IF 1.4 3区农林科学

Veterinary dermatology Pub Date : 2026-04-10 DOI: 10.1111/vde.70071

Camilo J Morales, Stephen D White, Verena K Affolter, Catherine A Outerbridge, K Gary Magdesian, Tyler J M Jordan

引用次数: 0