Veterinary dermatology最新文献

{"title":"Systemic Inflammation in Dogs With Atopic Dermatitis Compared to Healthy Dogs and Dogs With Pemphigus Foliaceus: A Study Using a Limited Cytokine Panel.","authors":"Ina Herrmann, Lisa B Mamo, Petra Bizikova","doi":"10.1111/vde.70118","DOIUrl":"https://doi.org/10.1111/vde.70118","url":null,"abstract":"<p><strong>Background: </strong>Atopic dermatitis (AD) is a common chronic, pruritic and inflammatory skin disease in both humans and dogs. In people, AD is increasingly recognised as a systemic inflammatory disease in which immune dysregulation drives chronic inflammation extending beyond the skin, particularly in moderate-to-severe disease. Whether a comparable systemic inflammation exists in canine AD, however, remains poorly characterised.</p><p><strong>Hypothesis/objectives: </strong>We hypothesised that serum cytokine concentrations would differ between dogs with varying AD severity and healthy controls. This study aimed to identify systemic inflammatory markers correlating with AD severity, by comparing cytokine profiles in dogs with mild AD and moderate-to-severe AD against healthy dogs (negative control) and dogs with active pemphigus foliaceus (PF) lesions (positive control).</p><p><strong>Animals: </strong>Forty client-owned dogs were enrolled, with 10 dogs in each of four groups: healthy controls, mild AD, moderate-to-severe AD and PF.</p><p><strong>Materials and methods: </strong>Serum concentrations of tumour necrosis factor (TNF)-α, TNF-β/lymphotoxin-α, interleukin (IL)-1β, IL-6, IL-12 and IL-1 receptor antagonist (IL-1RA) were measured using standardised immunoassays to evaluate systemic inflammation across groups.</p><p><strong>Results: </strong>Marked interindividual variability was observed across all groups. No statistically significant differences in serum concentrations of any of the six cytokines were detected between the healthy, mild AD, moderate-to-severe AD and PF groups.</p><p><strong>Conclusions and clinical relevance: </strong>In a limited cytokine panel, no evidence of differential systemic inflammation was detected across groups, including dogs with moderate-to-severe AD compared to healthy controls. These findings may reflect true lack of systemic inflammation in dogs or may be attributable to the small sample size, high interindividual variability or the limited scope of the cytokine panel evaluated.</p>","PeriodicalId":23599,"journal":{"name":"Veterinary dermatology","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2026-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148888691","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison Between Colorimetric and Subjective Evaluation of Intradermally Injected Histamine-Induced Erythema in Healthy Dogs.","authors":"Ana Petak, Elisa Samuel, Svetlina Aleksandrova, Evi I Sofou, Manolis K Chatzis, Manolis N Saridomichelakis","doi":"10.1111/vde.70123","DOIUrl":"https://doi.org/10.1111/vde.70123","url":null,"abstract":"<p><strong>Background: </strong>Currently used methods for the interpretation of intradermal allergen test results either ignore the erythema of the wheals (objective method) or evaluate it subjectively (subjective method, and global wheal score [GWS]).</p><p><strong>Objectives: </strong>To compare the efficacy of GWSs in differentiating between wheals induced by intradermal injection of a negative control and histamine at three different concentrations, using either the objective colorimetric measurement of erythema or the subjective evaluation of erythema as absent, weak, or strong.</p><p><strong>Animals: </strong>Seven clinically healthy dogs.</p><p><strong>Materials and methods: </strong>Duplicate intradermal injections of a negative control, histamine 0.0001%, histamine 0.001%, and histamine 0.01% were administered on the lateral thorax of the dogs. A colorimeter was used to measure erythema before and 15 min after the injection and, at the same time, three blinded investigators scored erythema subjectively.</p><p><strong>Results: </strong>The subtraction of the first colorimetric measurement of erythema obtained before intradermal injection from the first postinjection objective measurement (ΔEfirst) outperformed three other objective measurement methods and yielded GWSs capable of differentiation among the four solutions with efficiencies comparable to those of GWSs based on subjective erythema assessment. However, the stronger correlation between the later and wheal diameters may indicate bias in the subjective evaluation of erythema.</p><p><strong>Conclusions and clinical relevance: </strong>A single colorimetric measurement of erythema before and after intradermal injection of a negative control and histamine at three different concentrations, followed by calculation of their difference, can replace the subjective evaluation of erythema for the calculation of GWSs and avoid possible bias.</p>","PeriodicalId":23599,"journal":{"name":"Veterinary dermatology","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148867005","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnostic Performance of Immunoglobulin E Serology, Prick Test and Patch Test With Food Allergens in Dogs With Atopic Dermatitis and Adverse Food Reactions Using the Double-Blind Placebo-Controlled Food Challenge as Gold Standard.","authors":"Evi I Sofou, Svetlina Aleksandrova, Elisa Samuel, Manolis Chatzis, Manolis N Saridomichelakis","doi":"10.1111/vde.70119","DOIUrl":"https://doi.org/10.1111/vde.70119","url":null,"abstract":"<p><strong>Background: </strong>In dogs with adverse food reactions (AFRs), immunoglobulin (Ig)E serology, prick test and patch test with food allergens have shown variable diagnostic performance for the identification of the offending foods, when the latter were identified using open food challenges.</p><p><strong>Objectives: </strong>To evaluate the diagnostic performance of these tests in dogs with atopic dermatitis (AD) and AFRs, using the double-blind placebo-controlled food challenge (DBPCFC) as the gold standard.</p><p><strong>Animals: </strong>Twelve dogs with AD and AFRs underwent DBPCFCs with eight food items.</p><p><strong>Materials and methods: </strong>IgE serology, prick test and patch test with the same eight food allergens were performed after the diagnosis of AD and before the diagnostic investigation for AFRs and the DBPCFCs.</p><p><strong>Results: </strong>The sensitivity (3%-60.6%), specificity (54.8%-98.4%), positive predictive value (25%-66.7%) and negative predictive value (64.1%-72.3%) of the three tests and of their combination were unsatisfactory. Furthermore, their positive and negative likelihood ratio values were not in the clinically informative range, apart from the prick test having a weakly informative positive likelihood ratio value of 3.81.</p><p><strong>Conclusions and clinical relevance: </strong>Under the conditions of this study, the diagnostic performance of IgE serology, prick test and/or patch test with food allergens was poor using the DBPCFC as gold standard.</p>","PeriodicalId":23599,"journal":{"name":"Veterinary dermatology","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2026-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148850822","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Time Required for Topical Difluprednate to Suppress the Intradermal Histamine-Induced Vascular Reaction in Dogs.","authors":"Fusako Takeo, Nobuo Murayama, Kensuke Orito","doi":"10.1111/vde.70122","DOIUrl":"https://doi.org/10.1111/vde.70122","url":null,"abstract":"<p><strong>Background: </strong>Topical glucocorticoid (GC) is used to manage inflammatory skin diseases in dogs. However, contact times associated with detectable topical GC effects have not been clarified in dogs. Uncertainty regarding contact time may lead to premature removal or overuse, compromising efficacy and safety.</p><p><strong>Objectives: </strong>To determine contact times at which detectable GC effects are observed after topical difluprednate lotion application in dogs.</p><p><strong>Animals: </strong>Six male Beagle dogs.</p><p><strong>Methods: </strong>Suppression of the histamine-induced vascular reaction (HVR), based on the principles of the vasoconstrictor assay, was used as an indicator of detectable GC effects. Difluprednate lotion was applied to a circular area (2 cm in diameter) on the lateral trunk 5, 10 and 30 min before intradermal histamine injection. Fluorescein was administered intravenously 5 min before histamine injection to visualise HVR. HVR images were obtained 15 min after histamine injection under UV illumination, and the fluorescent area was measured using ImageJ. Statistical analysis was performed using Dunnett's multiple comparison test.</p><p><strong>Results: </strong>When difluprednate application was performed 5, 10 and 30 min before histamine injection, HVR areas were smaller than untreated control sites (p < 0.01). No significant differences were detected among sites treated 5, 10 and 30 min before histamine injection.</p><p><strong>Conclusions and clinical relevance: </strong>Difluprednate lotion suppressed the HVR when applied 5, 10 and 30 min before histamine injection, indicating detectable dermal GC activity at the evaluated time points. Information regarding contact times at which topical GC effects can be detected may help clinicians to provide contact-time instructions and improve treatment management.</p>","PeriodicalId":23599,"journal":{"name":"Veterinary dermatology","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2026-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148831959","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comments on Statistical Analysis of \"Comparative Efficacy and Safety of Ilunocitinib and Oclacitinib for the Control of Pruritus and Associated Skin Lesions in Dogs With Atopic Dermatitis\".","authors":"Michal Hakala, Eva Zschiesche, Petr Hala, Inka Kuhlmann","doi":"10.1111/vde.70121","DOIUrl":"https://doi.org/10.1111/vde.70121","url":null,"abstract":"","PeriodicalId":23599,"journal":{"name":"Veterinary dermatology","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2026-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148819703","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Randomised Placebo-Controlled Study to Evaluate the Efficacy and Safety of a Two-Dose Topical Terbinafine and Betamethasone Gel for the Treatment of Yeast (Malassezia pachydermatis) Otitis Externa in Dogs.","authors":"Zorica Zivkovic Baks, Hope Baird Heinz, Stephan Grundke, Caryn Thompson, Roberto Garcia","doi":"10.1111/vde.70113","DOIUrl":"https://doi.org/10.1111/vde.70113","url":null,"abstract":"<p><strong>Background: </strong>Otitis externa (OE) with Malassezia pachydermatis overgrowth with limited bacterial involvement is common in dogs. Treatment with products containing antibiotics is unnecessary and not consistent with judicious use of antimicrobials.</p><p><strong>Objectives: </strong>To evaluate the efficacy and safety of an otic gel containing 1% terbinafine and 0.1% betamethasone acetate for the treatment of yeast-predominant canine OE.</p><p><strong>Animals: </strong>239 privately owned dogs were enrolled.</p><p><strong>Materials and methods: </strong>Inclusion criteria were an otitis index score (OTIS3) of ≥ 6 and yeast-predominance on ear swab cytological evaluation. Dogs received either the study product containing terbinafine and betamethasone (TBG) or placebo (saline) on Day (D) 0 and D7. Follow-up visits were on D7, D14, D28 and D45. Clinical success was defined as an OTIS3 score ≤ 3 on D45. Overall clinical response (by the veterinary surgeon and owner) and yeast cytological count reduction also were assessed. Safety was evaluated based on clinical assessments, haematological and clinical chemical analysis, urinalysis and adverse events.</p><p><strong>Results: </strong>The treatment success was significantly higher in the treated group compared to the placebo group (62.9% versus 20.0%, p < 0.0001). Dogs receiving TBG had a treatment response described as 'excellent' or 'good' by 61.9% and 71.1% of veterinary surgeons and owners, respectively. The safety evaluation demonstrated that the otic gel was safe.</p><p><strong>Conclusions and clinical relevance: </strong>Efficacy and safety of an otic gel for the treatment of canine OE associated with Malassezia pachydermatis were demonstrated.</p>","PeriodicalId":23599,"journal":{"name":"Veterinary dermatology","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2026-08-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148814269","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence of Lesional and Nonlesional Dermatophytosis in Shelter/Rescue Guinea Pigs (Cavia porcellus) in Southern California, USA.","authors":"Y Peters, W Rosenkrantz, K Blessing, C Milley, K Keating, R Ghubash","doi":"10.1111/vde.70112","DOIUrl":"https://doi.org/10.1111/vde.70112","url":null,"abstract":"<p><strong>Background: </strong>Dermatophytosis is a contagious, zoonotic disease caused by fungal infection of keratinised structures of the skin, hair and nails. Transmission can be from newly acquired pets, including guinea pigs (Cavia porcellus).</p><p><strong>Objectives: </strong>The primary objective of this study was to determine the prevalence of dermatophytosis in guinea pigs before adoption from shelters/rescue organisations. Secondarily, test results were compared by modality for agreement.</p><p><strong>Animals: </strong>Samples were collected from 85 guinea pigs between 17 February and 27 September 2025 from five shelter/rescue locations in Southern California.</p><p><strong>Materials and methods: </strong>Each guinea pig was sampled by acetate tape preparation, superficial-to-deep skin scraping, trichogram, fungal culture, PCR and next-generation sequencing (NGS).</p><p><strong>Results: </strong>None of the 85 guinea pigs (0%) had abnormal trichogram findings. One animal (1.18%) was positive for Trichophyton benhamiae by culture and also was positive on PCR and NGS. PCR detected dermatophyte DNA in 54 of 85 animals (63.5%); NGS in six of 85 (7.06%), with four of 85 (4.71%) positive on both. Of those positive on at least one test, only three (of 56, 5.36%) had skin lesions consistent with dermatophytosis. Six animals had compatible lesions yet tested negative on all assays. Two animals (2.35%) harboured Gliricola porcelli.</p><p><strong>Conclusions and clinical relevance: </strong>Active dermatophyte infection was uncommon based upon culture results, yet positive genetic material testing suggests that many animals had potential dermatophyte environmental exposure. Poor agreement among diagnostic tests underscores the need for clinical interpretation and careful test selection in suspected dermatophytosis cases.</p>","PeriodicalId":23599,"journal":{"name":"Veterinary dermatology","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2026-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148798512","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"2026 Selected Abstracts for the North American Veterinary Dermatology Forum 29 April - 2 May 2026 in Indianapolis, Indiana.","authors":"","doi":"10.1111/vde.70116","DOIUrl":"https://doi.org/10.1111/vde.70116","url":null,"abstract":"","PeriodicalId":23599,"journal":{"name":"Veterinary dermatology","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2026-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148713748","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Symmetrical Lupoid Onychodystrophy in Review: Lessons Learned From 31 Cases.","authors":"Jessica R Calesso, Clarissa P Souza, Stephanie R Bruner, Adriane P C V Bicalho","doi":"10.1111/vde.70114","DOIUrl":"https://doi.org/10.1111/vde.70114","url":null,"abstract":"<p><strong>Background: </strong>Symmetrical lupoid onychodystrophy (SLO) is a complex disease that exclusively affects the claws of dogs and represents a therapeutic challenge. Biopsy sampling of the third phalanx for histopathological evaluation has historically been the recommended diagnostic test, yet clinical diagnosis is currently encouraged. Numerous treatment protocols of varying success have been proposed for dogs with this condition.</p><p><strong>Objectives: </strong>The goals of this study are to report clinical findings, treatment protocols and outcomes of dogs with SLO, to propose a rationale for the clinical diagnosis and to discuss therapies for SLO.</p><p><strong>Animals: </strong>Thirty-one dogs examined at a veterinary hospital from May 2004 to April 2024.</p><p><strong>Materials and methods: </strong>Retrospective analysis of medical records from dogs diagnosed with SLO.</p><p><strong>Results: </strong>The average age of dogs at disease onset and diagnosis was 7 years old. Nineteen breeds were represented. Thirty dogs were clinically diagnosed with SLO, mostly presenting with onychodystrophy and onychomadesis, and in one a biopsy sample was collected. Different therapeutic combinations including tetracyclines alone or with niacinamide, pentoxifylline, essential fatty acids (EFAs), vitamin E, biotin and ciclosporin were used for the initial and/or maintenance treatment of SLO.</p><p><strong>Conclusions and clinical relevance: </strong>The distinctive presentation of SLO supports its clinical diagnosis. Medical treatment seems to support a favourable long-term outcome, despite the wide variation in protocols and doses. EFAs were commonly used as initial and maintenance therapy, and tetracyclines could often be excluded from the treatment protocol, thus complying with good antimicrobial stewardship practice.</p>","PeriodicalId":23599,"journal":{"name":"Veterinary dermatology","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2026-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148680033","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Retrospective Comparison of Survival, Tumour Reduction and Relapse Outcomes Following Oclacitinib and CCNU Treatment in Dogs With Canine Epitheliotropic T-Cell Lymphoma.","authors":"Guanshen Brian Shen, Manijeh Mohammadi Dehcheshmeh, Esmaeil Ebrahimie, Evie Knight, Darren J Trott, Michael Shipstone","doi":"10.1111/vde.70115","DOIUrl":"https://doi.org/10.1111/vde.70115","url":null,"abstract":"<p><strong>Background: </strong>Canine epitheliotropic T-cell lymphoma (CETL) is an aggressive and generally incurable disease in dogs. CCNU (lomustine) is commonly used for management, even though it carries a significant risk of adverse effects. Several reports describe oclacitinib producing clinical improvement in affected dogs, yet comparative data between the two treatments are lacking.</p><p><strong>Objective: </strong>To compare the clinical outcomes in dogs with CETL treated with oclacitinib or CCNU, focussing on tumour reduction (response), survival time and time-to-relapse.</p><p><strong>Materials and methods: </strong>This retrospective review (2008-2024) included 23 client-owned dogs with confirmed CETL treated with either CCNU (n = 11) or oclacitinib (n = 12). Outcomes included response (reduction in measurable tumour burden), survival (time from histopathological diagnosis to death) and time-to-relapse (for dogs with complete or good responses). Clinical presentation and adverse effects also were recorded. Additionally, sex, age and weight were compared between treatment groups to investigate potential confounding factors.</p><p><strong>Results: </strong>No statistically significant differences were identified between oclacitinib and CCNU for response, survival or time-to-relapse (p > 0.05 for all). Kaplan-Meier survival analysis showed no significant difference in overall survival (log-rank test, p = 0.20). Oclacitinib was associated with fewer adverse effects and reduced monitoring intensity.</p><p><strong>Conclusions and clinical relevance: </strong>These findings suggest oclacitinib may offer outcomes comparable to CCNU for CETL, with fewer adverse effects and less intensive monitoring. The small, retrospective sample limits firm conclusions, yet these results indicate that oclacitinib could be a reasonable, possibly safer palliative option warranting further prospective study.</p>","PeriodicalId":23599,"journal":{"name":"Veterinary dermatology","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2026-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148674304","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}