Veterinary dermatology最新文献

Immunotherapy using pullulan-conjugated Der f 2 allergen in canine atopic dermatitis: An anti-inflammatory agent-sparing approach.

IF 1.9 3区农林科学

Veterinary dermatology Pub Date : 2024-12-17 DOI: 10.1111/vde.13315

Masahiko Nagata, Jin Kozakai, Aya Yoshida, Kana Kameyama, Hiromi Oboso, Hisanori Muto, Shoji Ogino, Toshihiro Tsukui

{"title":"Immunotherapy using pullulan-conjugated Der f 2 allergen in canine atopic dermatitis: An anti-inflammatory agent-sparing approach.","authors":"Masahiko Nagata, Jin Kozakai, Aya Yoshida, Kana Kameyama, Hiromi Oboso, Hisanori Muto, Shoji Ogino, Toshihiro Tsukui","doi":"10.1111/vde.13315","DOIUrl":"https://doi.org/10.1111/vde.13315","url":null,"abstract":"Background: Allergen immunotherapy is used as aetiological treatment for canine atopic dermatitis (cAD).Objective: To assess the anti-inflammatory agent-sparing effect over 1 year of immunotherapy using pullulan-conjugated recombinant Der f 2 (rDf2-P).Animals: Twenty-one privately owned dogs with cAD.Materials and methods: Dogs with mild clinical signs after ≥4 weeks of anti-inflammatory drug treatment received rDf2-P immunotherapy for 1 year. A monthly medication score (MS) was calculated, and clinical signs were assessed using Canine Atopic Dermatitis Extent and Severity Index (CADESI)-04, cAD Eczema Area and Severity for Shiba Inu and pruritus scores. Serum thymus and activation-regulated chemokine (TARC)/C-C Motif Chemokine Ligand-17 (CCL17) concentrations were assessed at the initial and final doses during the 6-week induction phase and every 3 months for 1 year thereafter in 16 cases.Results: The mean MS decreased significantly by 43.0% (p = 0.022), 60.9% (p = 0.003), 70.0% (p = 0.0004), 58.7% (p = 0.0004) and 49.3% (p = 0.029) at 2.5, 4.5, 7.5, 10.5 and 13.5 months, respectively. Drug-sparing effects, assessed with MS and adjusted by clinical scores were rated as excellent for 12 (57.1%) and 11 (52.4%) dogs, good for 3 (14.3%) and 1 (4.8%) dogs, fair for 0 and 3 (14.3%) dogs, and poor for 6 (28.6%) and 5 (23.8%) dogs at 4.5 and 13.5 months, respectively. The serum TARC/CCL17 concentrations were significantly lower in the samples with lower CADESI-04 scores (<17) than in those with higher CADESI-04 scores (>17) (p = 0.0002).Conclusions and clinical relevance: Der f 2-P immunotherapy can lead to a rapid reduction in anti-inflammatory drug use and serve as an effective proactive therapy for cAD.","PeriodicalId":23599,"journal":{"name":"Veterinary dermatology","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2024-12-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142839786","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Topical dexamethasone decelerates epithelial migration on the canine tympanic membrane.

IF 1.9 3区农林科学

Veterinary dermatology Pub Date : 2024-12-09 DOI: 10.1111/vde.13314

Jihyun Kim, Taeho Oh, Seulgi Bae

{"title":"Topical dexamethasone decelerates epithelial migration on the canine tympanic membrane.","authors":"Jihyun Kim, Taeho Oh, Seulgi Bae","doi":"10.1111/vde.13314","DOIUrl":"https://doi.org/10.1111/vde.13314","url":null,"abstract":"Background: Epithelial migration (EM) is integral to normal ear structure and function. Glucocorticoids are considered the first-line therapy for various external ear disorders; however, their effects on EM on the tympanic membrane (TM) and the external auditory canal (EAC) are understudied.Hypothesis/objectives: To test the hypothesis that topical dexamethasone decelerates EM on the TM, this study aimed to evaluate the effects of topical dexamethasone on EM on the TMs of dogs.Animals: Seven ears of four healthy dogs.Materials and methods: The migration distance of an ink drop deposited on the posterior quadrant of the pars tensa (TM EM rate) of dogs was calculated over 3 weeks from images captured with a video-otoscope. The results were compared by paired Student's t-test to those obtained from a subsequent experiment in which the same dogs were administered a fresh ink drop at the same position as previously (control group), yet additionally administered 0.1% dexamethasone (0.2 mL/ear) daily for the first 14 days (treatment group).Results: One of eight ears was excluded because of an anatomical problem. The TM EM rate of the remaining seven ears decreased by 46.74% in the treatment group compared with the control group (p < 0.05).Conclusions and clinical relevance: Topical dexamethasone decelerates EM on the TM of normal dogs' ears. In turn, it is extrapolated that debris removal from the EAC may be slowed, negatively impacting the EAC environment. Consequently, when dogs with otitis receive topical dexamethasone treatment, additional treatment, such as ear canal cleaning, may be required to minimise the effects of impaired TM EM.","PeriodicalId":23599,"journal":{"name":"Veterinary dermatology","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2024-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142795181","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Localised apolipoprotein A-I amyloidosis arising in a fibroadnexal hamartoma in a dog.

IF 1.9 3区农林科学

Veterinary dermatology Pub Date : 2024-12-09 DOI: 10.1111/vde.13316

Tomoaki Murakami, Kenta Owaku, Natsumi Kobayashi, Yoshiyuki Itoh, Miki Hisada, Linden E Craig

引用次数: 0

Skin barrier, phenotypic and genotypic characterisation of autosomal recessive ichthyosis in TGM1-deficient Jack Russell Terriers and response to topical ceramide. TGM1缺陷杰克罗素梗犬常染色体隐性鱼鳞病的皮肤屏障、表型和基因型特征以及对局部神经酰胺的反应。

IF 1.9 3区农林科学

Veterinary dermatology Pub Date : 2024-12-01 Epub Date: 2024-08-08 DOI: 10.1111/vde.13285

Elizabeth Mauldin, Charles Bradley, Margret Casal, Jason Meyer, Debra Crumrine, Sarah Kiener, Tosso Leeb, Peter M Elias

{"title":"Skin barrier, phenotypic and genotypic characterisation of autosomal recessive ichthyosis in TGM1-deficient Jack Russell Terriers and response to topical ceramide.","authors":"Elizabeth Mauldin, Charles Bradley, Margret Casal, Jason Meyer, Debra Crumrine, Sarah Kiener, Tosso Leeb, Peter M Elias","doi":"10.1111/vde.13285","DOIUrl":"10.1111/vde.13285","url":null,"abstract":"Background: Autosomal recessive ichthyosis leads to structural or biochemical changes that impair skin barrier function.Hypothesis/objectives: To assess (1) the phenotype and genotype in a litter of Jack Russell Terriers with autosomal recessive congenital ichthyosis (ARCI), and (2) the defective skin barrier and determine if a topical ceramide can modulate the barrier.Animals: A healthy dam and litter of Jack Russell Terrier puppies (healthy male, affected male and female), one affected adult Jack Russell Terrier and one unrelated healthy Jack Russell Terrier.Materials and methods: A severe cornification defect was identified via examination of affected puppies. As the phenotype worsened, the affected puppies received a topical application of ω-0-acylceramide for 10 days. Before humane euthanasia, the skin barrier was evaluated via transepidermal water loss (TEWL), corneometry and pH in affected dogs. Genomic testing was performed, and skin samples were analysed by light and electron microscopy.Results: Affected puppies were homozygous for the 1980 bp LINE-1 insertion in the TGM1 (transglutaminase 1) gene; the unaffected littermate and the dam were heterozygous carriers. ARCI puppies were underweight and had a severe hyperkeratotic phenotype that impaired mobility. TEWL was markedly higher in affected dogs. The cutaneous pH of affected puppies was higher than the normal littermate. Treatment of the skin with ω-0-acylceramide normalised the pH to match the littermate and decreased TEWL. Electron microscopy revealed marked attenuation of the cornified envelope.Conclusions and clinical relevance: Dogs with TGM1-deficient ARCI have an impaired skin barrier. Topical therapy can partially repair the barrier defect.","PeriodicalId":23599,"journal":{"name":"Veterinary dermatology","volume":" ","pages":"617-625"},"PeriodicalIF":1.9,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141907732","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Therapeutic efficacy of cold atmospheric plasma in four golden retrievers with acute otitis externa. 冷大气等离子体对四只患有急性外耳道炎的金毛猎犬的治疗效果。

IF 1.9 3区农林科学

Veterinary dermatology Pub Date : 2024-12-01 Epub Date: 2024-08-14 DOI: 10.1111/vde.13287

Alanur Bakır, Claudia Susanne Nett-Mettler, Bulent Ulutas

{"title":"Therapeutic efficacy of cold atmospheric plasma in four golden retrievers with acute otitis externa.","authors":"Alanur Bakır, Claudia Susanne Nett-Mettler, Bulent Ulutas","doi":"10.1111/vde.13287","DOIUrl":"10.1111/vde.13287","url":null,"abstract":"Background: Cold atmospheric plasma (CAP) is a new therapeutic tool used to treat various skin diseases in humans and animals.Objective: To evaluate the effect of CAP in the treatment of canine acute otitis externa (AOE).Animals: Four client-owned golden retriever dogs with bilateral AOE.Methods and materials: After cleaning with a commercial ear cleanser, right ears (STANDARD group) were treated with an antibiotic/antifungal/corticosteroid combination and left ears (CAP group) were treated with CAP every three days for a total of four treatments. Cytological score and otitis index score (OTIS)3 were recorded for each ear on Day (D)0, D10 and D15. At D10 and D15, owners and investigators recorded an overall assessment.Results: In both groups, OTIS3 and cytological score decreased over the study period. The overall assessment scale ranged from moderate to excellent in both groups.Conclusions and clinical relevance: Cold atmospheric plasma treatment showed equal therapeutic effect compared with a commercial topical anti-inflammatory and antimicrobial ear treatment.","PeriodicalId":23599,"journal":{"name":"Veterinary dermatology","volume":" ","pages":"745-749"},"PeriodicalIF":1.9,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141976744","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Long-term use of lokivetmab in dogs with atopic dermatitis. 在患有特应性皮炎的狗中长期使用 lokivetmab。

IF 1.9 3区农林科学

Veterinary dermatology Pub Date : 2024-12-01 Epub Date: 2024-08-14 DOI: 10.1111/vde.13286

Bettina Kasper, Yury Zablotski, Ralf S Mueller

{"title":"Long-term use of lokivetmab in dogs with atopic dermatitis.","authors":"Bettina Kasper, Yury Zablotski, Ralf S Mueller","doi":"10.1111/vde.13286","DOIUrl":"10.1111/vde.13286","url":null,"abstract":"Background: Lokivetmab, a caninised monoclonal antibody against interleukin (IL)-31, is an effective treatment for the pruritus associated with canine atopic dermatitis (cAD).Objectives: To investigate the efficacy and safety of lokivetmab during long-term treatment defined as at least three consecutive lokivetmab injections in atopic dogs under field conditions. To assess individual factors influencing treatment outcome and adverse events.Animals: 150 dogs with cAD.Materials and methods: Medical records of dogs treated with lokivetmab were reviewed, and owners and/or veterinarians were contacted as needed for follow-up. A decrease of the pruritus Visual Analog Scale (PVAS) score by ≥2 or a PVAS score ≤2 after treatment was considered as treatment success. Logistic regression was used to investigate the influence of a variety of factors on outcome: type of cAD (food versus environment), age at first lokivetmab administration, disease chronicity, dosage and/or secondary infection. Any adverse event that occurred during the study period was recorded.Results: Lokivetmab reduced the PVAS score with long-term use (p < 0.01); the success rate was 53 of 69 total dogs (77%). The probability of treatment failure decreased with increasing treatment duration. None of the factors investigated influenced the treatment outcome. Twelve dogs of 150 (8%) showed adverse events such as gastrointestinal signs or lethargy.Conclusion and clinical relevance: Lokivetmab appears to be an effective and safe long-term anti-itch therapy for dogs with cAD.","PeriodicalId":23599,"journal":{"name":"Veterinary dermatology","volume":" ","pages":"683-693"},"PeriodicalIF":1.9,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141983355","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of ear cleaning on treatment outcome for canine otitis externa. 洗耳对犬外耳道炎治疗效果的影响

IF 1.9 3区农林科学

Veterinary dermatology Pub Date : 2024-12-01 Epub Date: 2024-08-30 DOI: 10.1111/vde.13292

Erin Corb, Craig E Griffin, Willie Bidot, Melissa Hall, Allison Kirby, Wayne Rosenkrantz

{"title":"Effect of ear cleaning on treatment outcome for canine otitis externa.","authors":"Erin Corb, Craig E Griffin, Willie Bidot, Melissa Hall, Allison Kirby, Wayne Rosenkrantz","doi":"10.1111/vde.13292","DOIUrl":"10.1111/vde.13292","url":null,"abstract":"Background: Ear cleaning is often recommended for management of canine otitis externa (OE). Few in vivo studies evaluate how ear cleaning affects treatment outcome.Hypothesis/objectives: To determine the effect of ear cleaning on canine OE by comparing treatment outcome in cleaned versus noncleaned ears.Animals: Twenty-three client-owned dogs with ceruminous or purulent OE.Materials and methods: Forty ears were randomised to one of two groups: 20 ears were wiped with dry or saline-moistened gauze (grp1), and 20 external ear canals received manual cleaning (grp2) with a commercial product. One millilitre of a commercial otic suspension containing hydrocortisone aceponate, miconazole nitrate and gentamicin sulfate was applied to affected ears every 24 h for five days. Cytological scores, modified otitis index score (OTIS3), pruritus Visual Analog Scale (PVAS), modified PVAS and client questionnaire were compared on Day (D)0 and D7.Results: There were no statistical differences between cytological scores, modified OTIS3, PVAS, modified PVAS or client assessments between groups at D7. Both groups had significant reduction in all treatment parameters from D0 to D7 with the exception of cytological rod scores that were only significantly decreased in cleaned ears. There was a significant difference in OTIS3 before and after cleaning on D0.Conclusions and clinical relevance: Both groups achieved successful outcome regardless of cleaning. Ear cleaning may be more important when rod-shaped bacteria are present.","PeriodicalId":23599,"journal":{"name":"Veterinary dermatology","volume":" ","pages":"716-725"},"PeriodicalIF":1.9,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142112511","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

In vitro efficacy of lavender oil, otological gel and gentamicin to eradicate biofilm produced by Pseudomonas aeruginosa. 薰衣草精油、耳用凝胶和庆大霉素对消除铜绿假单胞菌产生的生物膜的体外疗效。

IF 1.9 3区农林科学

Veterinary dermatology Pub Date : 2024-12-01 Epub Date: 2024-08-30 DOI: 10.1111/vde.13294

Ana Mourão, Isa Serrano, Eva Cunha, Luís Tavares, Ana Lourenço, Manuela Oliveira

{"title":"In vitro efficacy of lavender oil, otological gel and gentamicin to eradicate biofilm produced by Pseudomonas aeruginosa.","authors":"Ana Mourão, Isa Serrano, Eva Cunha, Luís Tavares, Ana Lourenço, Manuela Oliveira","doi":"10.1111/vde.13294","DOIUrl":"10.1111/vde.13294","url":null,"abstract":"Background: Otitis externa (OE) is one of the most frequently diagnosed dermatological diseases in dogs, having a multifactorial aetiology. Among the bacterial agents associated with canine OE, Pseudomonas aeruginosa is of special concern owing to its frequent multidrug resistance profile and ability to form biofilms related to the infection's chronicity and recurrence.Objectives: The main objective of this study was to evaluate and compare the antibiofilm activity of two innovative antimicrobials-an otological gel containing a synthetic antimicrobial peptide and Lavandula angustifolia essential oil-with gentamicin (a conventional antibiotic) using biofilm-producing P. aeruginosa isolates obtained from dogs with OE.Materials and methods: The biofilm eradication capacity of gentamicin, otological gel and lavender oil was determined against a collection of 12 P. aeruginosa biofilm-producers among 35 clinical isolates obtained from the ear canals of dogs with OE. Also, the antimicrobial activity of the otological gel against P. aeruginosa biofilms was assessed in an in vitro model of dog cerumen.Results: Lavender oil showed the best effectiveness after 30 min of contact, eradicating 58.3% (seven of 12) of the isolates, and gentamicin showed full eradication (12 of 12) after 24 h. The otological gel acted more slowly than the lavender oil; yet at 24 h, the antibiofilm capacity of both compounds was similar, with no significant difference between them. It also was found that triglycerides from synthetic cerumen earwax had antipseudomonal activity and, when combined with the otological gel, led to the full eradication of P. aeruginosa.Conclusions and clinical relevance: The results of this in vitro study indicate that lavender oil and the otological gel may be effective topical treatments for canine OE promoted by P. aeruginosa biofilm-producers, as alternatives to gentamicin.","PeriodicalId":23599,"journal":{"name":"Veterinary dermatology","volume":" ","pages":"726-735"},"PeriodicalIF":1.9,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142112513","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Analysis of the immunomodulatory properties of mycobacterium cell wall fraction on the cytokine production of peripheral blood mononuclear cells of healthy dogs. 分析分枝杆菌细胞壁成分对健康狗外周血单核细胞细胞因子产生的免疫调节作用。

IF 1.9 3区农林科学

Veterinary dermatology Pub Date : 2024-12-01 Epub Date: 2024-08-14 DOI: 10.1111/vde.13288

Robert Ward, Geoffrey A Wood, Charlotte Pye, Khalil Karimi, Anthony Yu, Myles St-Denis, Katherine Blake, Sugandha Raj, Samson Oladokun, Shayan Sharif

{"title":"Analysis of the immunomodulatory properties of mycobacterium cell wall fraction on the cytokine production of peripheral blood mononuclear cells of healthy dogs.","authors":"Robert Ward, Geoffrey A Wood, Charlotte Pye, Khalil Karimi, Anthony Yu, Myles St-Denis, Katherine Blake, Sugandha Raj, Samson Oladokun, Shayan Sharif","doi":"10.1111/vde.13288","DOIUrl":"10.1111/vde.13288","url":null,"abstract":"Background: Mycobacterium cell wall fraction (MCWF) is derived from nonpathogenic Mycobacterium phlei and is used as an immunomodulatory compound in clinical practice, yet its mode-of-action requires further research.Objective: To evaluate the host response to MCWF in canine peripheral blood mononuclear cells (PBMCs) by using enzyme-linked immunosorbent assays (ELISA) and quantitative reverse transcription (qRT)-PCR for assessment of cytokines.Animals: Eight healthy Labrador retrievers.Materials and methods: PBMCs were isolated from whole blood using density centrifugation. The cells were cultured with different concentrations of MCWF or a potent stimulator of cytokine production, phorbol 12-myristate 13-acetate/ionomycin, or left in cell culture medium for 24, 48 and 72 h. Cytokines were measured by ELISA for interleukin (IL)-4, IL-10 and interferon-gamma (IFN-γ), and by qRT-PCR for IL-4, IL-10, IL-13, IFN-γ, tumour necrosis factor alpha (TNF-α) and transforming growth factor-beta.Results: A significant increase of IL-10 messenger ribonucleic acid (mRNA) was detected at all time points for all concentrations of MCWF (p < 0.05). Protein analysis reflected this finding, with a maximum IL-10 concentration of 300.6 ± 38.3 μg/mL. Compared to the negative control, post-stimulation elevation of IFN-γ mRNA was noted at 24 h with all concentrations of MCWF (p < 0.01), and TNF-α mRNA was increased for 0.5 μg/dL MCWF only at 72 h (p < 0.05).Conclusions and clinical relevance: MCWF stimulation of PBMCs results in the elevation of both proinflammatory and regulatory cytokine mRNA. Further research into the role of MCWF as a systemically administered regulatory immunomodulator or adjuvant to allergen-specific immunotherapy should be considered.","PeriodicalId":23599,"journal":{"name":"Veterinary dermatology","volume":" ","pages":"595-604"},"PeriodicalIF":1.9,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141976743","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correlation between meibomian gland dysfunction and sebaceous adenitis in dogs. 狗的睑板腺功能障碍与皮脂腺炎之间的相关性。

IF 1.9 3区农林科学

Veterinary dermatology Pub Date : 2024-12-01 Epub Date: 2024-08-30 DOI: 10.1111/vde.13293

Giulia Striuli, Sophie Vandenabeele, Filip Nachtegaele, Nausikaa Devriendt

{"title":"Correlation between meibomian gland dysfunction and sebaceous adenitis in dogs.","authors":"Giulia Striuli, Sophie Vandenabeele, Filip Nachtegaele, Nausikaa Devriendt","doi":"10.1111/vde.13293","DOIUrl":"10.1111/vde.13293","url":null,"abstract":"Background: Sebaceous adenitis (SA) is an immune-mediated disease targeting the sebaceous glands. Meibomian gland dysfunction is a disease affecting meibomian glands with inflammatory features. Sebaceous and meibomian glands share anatomical, physiological and embryological similarities. The involvement of meibomian glands in dogs with SA is currently unknown.Objectives: To evaluate meibomian glands in dogs affected by SA and compare them with healthy dogs.Animals: Eighteen dogs were enrolled. Nine dogs with SA were retrospectively identified from clinical records and represented the case group. Nine healthy, breed- and age-matched dogs were prospectively enrolled in the control group.Materials and methods: Both groups underwent dermatological examination, Schirmer tear test-1 (STT-1), tear meniscus height (TMH), slit-lamp biomicroscopy, interferometry (INT) and noncontact infrared meibography (NIM).Results: One third of SA dogs presented subepithelial crystalline opacities. No significant difference between groups was observed in TMH (p = 0.944) and STT-1 values (p = 0.066). INT (p = 0.016) and NIM grades (p = 0.010) were significantly higher and lower in the SA group compared to the control group, respectively. INT values decreased with age (η = 0.930), while NIM scores (η = 0.935) increased.Conclusions: Clinical Relevance: Subepithelial crystalline opacities in SA dogs might reflect a reduced tear film quality. In the absence of standardised methods, INT and NIM proved to be noninvasive and useful methods to examine meibomian glands. Dogs with SA showed a thinner lacrimal lipid layer and more severe meibomian gland abnormalities than control dogs, which seemed to progress with age.","PeriodicalId":23599,"journal":{"name":"Veterinary dermatology","volume":" ","pages":"605-616"},"PeriodicalIF":1.9,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142112510","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0