含有沙乐灵、莫西菌素和吡蚜酮的咀嚼片治疗犬全身性脱皮病的疗效。

IF 1.9 3区 农林科学 Q3 DERMATOLOGY
Csilla Becskei, Julian Liebenberg, Tiago Fernandes, Stasia Borowski, Lina D'Hanis, Sean P Mahabir
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引用次数: 0

摘要

背景:犬脱毛症是一种常见病,由共生的犬脱毛螨增殖引起:犬脱毛症是犬的常见病,由共生的犬脱毛螨增殖引起:评估沙乐胺联合莫西菌素和吡蚜酮(SMP)治疗犬全身性脱皮病的疗效:130只患有全身性脱皮症的狗:在两项独立的随机掩蔽研究(实验室研究和现场研究)中,狗每月口服一次 SMP 或阿福霉素+米尔贝霉素肟(AM)。在实验室研究中,狗每月接受三次治疗,每两周进行一次螨虫计数和临床评估。在实地研究中,每月进行一次螨虫计数和临床评估,直到连续两次皮肤刮片呈阴性为止:结果:两种产品的耐受性都很好。在实验室研究中,SMP 的螨虫计数与临床相关性显著(p 结论):每月使用 SMP 能有效治疗犬的全身性脱皮病,因为在实验室研究中,每月使用两次 SMP 就能消灭螨虫,而在实地研究中,最多每月使用三次 SMP 就能消灭螨虫。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Efficacy of a chewable tablet containing sarolaner, moxidectin and pyrantel for the treatment of generalised demodicosis in dogs.

Background: Demodicosis is common in dogs and is caused by proliferation of commensal Demodex canis mites.

Objective: To evaluate the efficacy of sarolaner in combination with moxidectin and pyrantel (SMP) for the treatment of generalised demodicosis in dogs.

Animals: One hundred and thirty dogs with generalised demodicosis.

Materials and methods: In two separate randomised masked studies (laboratory and field studies), dogs received monthly oral SMP or afoxolaner + milbemycin oxime (AM). In the laboratory study, dogs received three monthly treatments with biweekly mite counts and clinical evaluations. In the field study, mite counts and clinical evaluations were performed monthly and treatments were administered until two consecutive skin scrapings were negative.

Results: Both products were tolerated well. In the laboratory study, mite counts for SMP were significantly (p < 0.001) reduced by 88.8% on Day (D)14, by 99.2% on D29, and no live mites were detected thereafter with no statistically significant difference (p = 0.96) between the two treatment groups. In the field study, SMP provided 92.4%, 98.1%, 100% and 100% reduction in arithmetic mean live mite counts on D30, D60, D90 and D120, and was non-inferior to the control product on D30 and D60. Clinical signs of demodicosis improved in all dogs.

Conclusions and clinical relevance: Monthly administration of SMP was effective for the treatment of generalised demodicosis in dogs as it eliminated Demodex mites after two monthly treatments in the laboratory study, and at most after three monthly treatments in the field study.

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来源期刊
Veterinary dermatology
Veterinary dermatology 农林科学-兽医学
CiteScore
3.20
自引率
21.40%
发文量
92
审稿时长
12-24 weeks
期刊介绍: Veterinary Dermatology is a bi-monthly, peer-reviewed, international journal which publishes papers on all aspects of the skin of mammals, birds, reptiles, amphibians and fish. Scientific research papers, clinical case reports and reviews covering the following aspects of dermatology will be considered for publication: -Skin structure (anatomy, histology, ultrastructure) -Skin function (physiology, biochemistry, pharmacology, immunology, genetics) -Skin microbiology and parasitology -Dermatopathology -Pathogenesis, diagnosis and treatment of skin diseases -New disease entities
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