发布求助
文献互助 智能选刊 最新文献

Trends in Neurosciences最新文献

筛选
英文 中文
From chromatin dynamics to brain disease: Polycomb-Trithorax mechanisms in neurodevelopment. 从染色质动力学到脑部疾病：神经发育中的Polycomb-Trithorax机制。
IF 15.7 1区 医学
Trends in Neurosciences Pub Date : 2026-08-01 Epub Date: 2026-07-02 DOI: 10.1016/j.tins.2026.06.001
Victoria L Castro, Matthew B So, Jamy C Peng
{"title":"From chromatin dynamics to brain disease: Polycomb-Trithorax mechanisms in neurodevelopment.","authors":"Victoria L Castro, Matthew B So, Jamy C Peng","doi":"10.1016/j.tins.2026.06.001","DOIUrl":"10.1016/j.tins.2026.06.001","url":null,"abstract":"<p><p>Neurogenesis requires precise coordination of gene expression, a process governed by the Polycomb (PcG) and Trithorax (TrxG) group proteins. In this review, we discuss how these proteins balance stem cell maintenance with neuronal differentiation and how the disruption of these processes may contribute to neurodevelopmental disorders and pediatric brain tumors. Recent studies have uncovered how PcG-TrxG dynamics and poised/bivalent chromatin states regulate developmental timing and lineage choice. Dysregulation of these epigenetic dynamics perturbs neuronal maturation and can drive aberrant developmental programs in pediatric brain disorders. These insights reveal how PcG-TrxG imbalance alters developmental trajectories and links chromatin dysregulation to disease. These epigenetic pathways are promising therapeutic targets for neurodevelopmental disorders and pediatric brain tumors.</p>","PeriodicalId":23325,"journal":{"name":"Trends in Neurosciences","volume":" ","pages":"682-696"},"PeriodicalIF":15.7,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13336298/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148377075","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Neuronal STAT1 as a phase switch from antiviral defense to synaptopathy in encephalitis. 脑炎中神经元STAT1作为从抗病毒防御到突触病的相位开关。
IF 15.7 1区 医学
Trends in Neurosciences Pub Date : 2026-07-01 Epub Date: 2026-05-13 DOI: 10.1016/j.tins.2026.04.007
Giovanni Di Liberto, Doron Merkler
{"title":"Neuronal STAT1 as a phase switch from antiviral defense to synaptopathy in encephalitis.","authors":"Giovanni Di Liberto, Doron Merkler","doi":"10.1016/j.tins.2026.04.007","DOIUrl":"10.1016/j.tins.2026.04.007","url":null,"abstract":"<p><p>Interferon signaling is essential for antiviral defense in the central nervous system, yet sustained neuronal STAT1 phosphorylation (pSTAT1) can promote immune-mediated synaptic and network injury. In this opinion article, we argue that neuronal pSTAT1 functions as a context-dependent switch across viral and autoimmune encephalitis, shifting from antiviral protection to durable synaptopathy and excitability changes when interferon signaling persists. Integrating mechanistic, epigenomic, and translational evidence from mouse models and human neuropathology, we propose that prolonged neuronal pSTAT1 drives a durable synaptopathic program by silencing synaptic gene networks and epigenetic 'locking' of dysfunctional circuits. We discuss therapeutic opportunities and risks of targeting the JAK-STAT1 axis, emphasizing the trade-off between neuroprotection and antiviral immunity.</p>","PeriodicalId":23325,"journal":{"name":"Trends in Neurosciences","volume":" ","pages":"509-521"},"PeriodicalIF":15.7,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147933899","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
TRAPing trigeminal ganglion neurons driving mechanical allodynia. 诱捕三叉神经节神经元驱动机械异常性痛。
IF 15.7 1区 医学
Trends in Neurosciences Pub Date : 2026-07-01 Epub Date: 2026-05-15 DOI: 10.1016/j.tins.2026.04.008
Dong Dong, Longzhen Cheng
{"title":"TRAPing trigeminal ganglion neurons driving mechanical allodynia.","authors":"Dong Dong, Longzhen Cheng","doi":"10.1016/j.tins.2026.04.008","DOIUrl":"10.1016/j.tins.2026.04.008","url":null,"abstract":"<p><p>How does brushing one's hair become agony? In a recent study, Li, Son, and colleagues genetically isolated the specific trigeminal afferents that transduce touch into pain after nerve injury, revealing a critical role for Piezo2 in driving both evoked mechanical hypersensitivity and ongoing spontaneous activity within a heterogeneous afferent ensemble.</p>","PeriodicalId":23325,"journal":{"name":"Trends in Neurosciences","volume":" ","pages":"504-505"},"PeriodicalIF":15.7,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147949614","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The 'neat' and 'messy' in task-dependent neural geometry and computation. 任务依赖神经几何与计算中的“整洁”与“凌乱”。
IF 15.7 1区 医学
Trends in Neurosciences Pub Date : 2026-07-01 Epub Date: 2026-05-26 DOI: 10.1016/j.tins.2026.04.012
Cheng Xue, Gouki Okazawa
{"title":"The 'neat' and 'messy' in task-dependent neural geometry and computation.","authors":"Cheng Xue, Gouki Okazawa","doi":"10.1016/j.tins.2026.04.012","DOIUrl":"10.1016/j.tins.2026.04.012","url":null,"abstract":"<p><p>To solve diverse real-world tasks, the brain must flexibly switch between task rules and adjust computations. Recent advances in analyzing neural data and modeling neural networks have revealed their 'neat' features: neuronal population activity encodes distinct task states and forms structured, interpretable representations of task variables, enabling efficient task switching. However, 'messy' features are also observed: task-irrelevant variables shape neuronal responses, representations become entangled, and behaviors exhibit apparent suboptimalities such as switch costs. We review these dual facets of experimental observations of task-dependent computation in the brain, particularly in primates. Recognizing this duality points to two future directions: refining theories to better capture brain-specific constraints and leveraging network models fitted directly to behavioral and neural data.</p>","PeriodicalId":23325,"journal":{"name":"Trends in Neurosciences","volume":" ","pages":"522-535"},"PeriodicalIF":15.7,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148035520","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A holistic perspective on noninvasive brain-computer interfaces. 非侵入性脑机接口的整体视角。
IF 15.7 1区 医学
Trends in Neurosciences Pub Date : 2026-07-01 Epub Date: 2026-05-25 DOI: 10.1016/j.tins.2026.04.009
Yidan Ding, Joshua Kosnoff, Bin He
{"title":"A holistic perspective on noninvasive brain-computer interfaces.","authors":"Yidan Ding, Joshua Kosnoff, Bin He","doi":"10.1016/j.tins.2026.04.009","DOIUrl":"10.1016/j.tins.2026.04.009","url":null,"abstract":"<p><p>Brain-computer interfaces (BCIs) decode neural activity to enable direct communication with external devices. This process consists of three modules: signal acquisition, signal processing, and output translation. While invasive BCIs have demonstrated sophisticated and intuitive capabilities, their reliance on surgical implantation limits widespread use. Noninvasive BCIs, in contrast, are more broadly applicable but have traditionally been constrained by low spatial resolution and suboptimal signal quality. Emerging methodological advances are beginning to overcome these limitations. In this review, we examine recent progress in noninvasive BCIs, focusing on neuromodulation-paired BCIs for signal enhancement, deep neural network-based signal processing approaches, and expanded applications through robotic integration. Together, these parallel developments are driving the emergence of more robust, intuitive, and adaptive BCI systems for human use.</p>","PeriodicalId":23325,"journal":{"name":"Trends in Neurosciences","volume":" ","pages":"566-581"},"PeriodicalIF":15.7,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13232709/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148017499","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Enteric neuroimmune interactions in health and disease. 肠道神经免疫在健康和疾病中的相互作用。
IF 15.7 1区 医学
Trends in Neurosciences Pub Date : 2026-07-01 Epub Date: 2026-06-15 DOI: 10.1016/j.tins.2026.05.006
Yifan Qu, Yuxuan Zhang, Shiming Zhou, Tao Yang, Coco Chu
{"title":"Enteric neuroimmune interactions in health and disease.","authors":"Yifan Qu, Yuxuan Zhang, Shiming Zhou, Tao Yang, Coco Chu","doi":"10.1016/j.tins.2026.05.006","DOIUrl":"10.1016/j.tins.2026.05.006","url":null,"abstract":"<p><p>The intestine contains a dense intrinsic nervous system that is closely integrated with local immune cells to coordinate motility, barrier defense, and tissue repair. Recent studies, primarily in mice and supported by emerging human evidence, have identified diverse enteric neuroimmune pathways through which enteric neurons shape immune cell responses, while immune cells, in turn, influence neuronal survival and function across distinct intestinal compartments. These bidirectional interactions are increasingly implicated in intestinal disorders, including Hirschsprung's disease, irritable bowel syndrome, inflammatory bowel disease, and infection-induced dysmotility. In this review, we summarize the anatomical basis and principal mechanisms of enteric neuroimmune communication, highlight recent advances in the field, and discuss key unresolved questions and future directions.</p>","PeriodicalId":23325,"journal":{"name":"Trends in Neurosciences","volume":" ","pages":"551-565"},"PeriodicalIF":15.7,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148259620","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Third spaces for science: reimagining research beyond academia and industry. 科学的第三个空间：重新构想超越学术界和工业界的研究。
IF 15.7 1区 医学
Trends in Neurosciences Pub Date : 2026-07-01 Epub Date: 2026-05-19 DOI: 10.1016/j.tins.2026.04.010
Meike Ramon, Bigna Lenggenhager, Marte Roel Lesur, Dila Suay, Linda Baines, Amanda J Haste
{"title":"Third spaces for science: reimagining research beyond academia and industry.","authors":"Meike Ramon, Bigna Lenggenhager, Marte Roel Lesur, Dila Suay, Linda Baines, Amanda J Haste","doi":"10.1016/j.tins.2026.04.010","DOIUrl":"10.1016/j.tins.2026.04.010","url":null,"abstract":"<p><p>Science is a public good, yet the spaces where it is produced remain structurally constrained. Independent researchers, citizen scientists, and practitioners often lack access to institutional conditions needed for scientific work that is sustainable and publicly perceived as credible. We argue for third spaces-autonomous, collaborative ecosystems-as essential complements to academia and industry, promoting a distributed, transdisciplinary, and democratic knowledge ecology.</p>","PeriodicalId":23325,"journal":{"name":"Trends in Neurosciences","volume":" ","pages":"501-503"},"PeriodicalIF":15.7,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147975845","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Atomic insights into the physiological and functional diversity of NMDA receptors. NMDA受体生理和功能多样性的原子见解。
IF 15.7 1区 医学
Trends in Neurosciences Pub Date : 2026-07-01 Epub Date: 2026-06-09 DOI: 10.1016/j.tins.2026.05.004
Ke Xu, Siming Wu, Shujia Zhu
{"title":"Atomic insights into the physiological and functional diversity of NMDA receptors.","authors":"Ke Xu, Siming Wu, Shujia Zhu","doi":"10.1016/j.tins.2026.05.004","DOIUrl":"10.1016/j.tins.2026.05.004","url":null,"abstract":"<p><p>N-methyl-D-aspartate receptors (NMDARs) are essential for brain development, memory processes, and cognition. They primarily act as coincidence detectors at the synapse, integrating presynaptic glutamate release and postsynaptic membrane depolarization to open the channel gate. This allows the influx of cations (mainly calcium) into the postsynaptic neuron and triggers downstream signaling for synaptic plasticity. These receptors exhibit significant diversity in atomic structure, subunit composition, pharmacological properties, and biophysical characteristics. Advances in cryo-electron microscopy (cryo-EM) imaging have unlocked the structures of most recombinant NMDAR subtypes, providing a framework to understand their gating and pharmacological diversity. Furthermore, the ability to extract native NMDARs from rodent brain now positions the field to uncover their unique stoichiometry, assembly, and physiology in vivo. This review presents a synthesis of the emerging understanding of NMDAR physiological diversity and subtype-selective negative and positive allosteric modulation at atomic resolution, and it discusses potential directions for designing therapeutics based on these insights.</p>","PeriodicalId":23325,"journal":{"name":"Trends in Neurosciences","volume":" ","pages":"582-600"},"PeriodicalIF":15.7,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148212290","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The neural basis of laughter. 笑的神经基础。
IF 15.7 1区 医学
Trends in Neurosciences Pub Date : 2026-07-01 Epub Date: 2026-06-23 DOI: 10.1016/j.tins.2026.05.002
Fausto Caruana, Sophie K Scott
{"title":"The neural basis of laughter.","authors":"Fausto Caruana, Sophie K Scott","doi":"10.1016/j.tins.2026.05.002","DOIUrl":"10.1016/j.tins.2026.05.002","url":null,"abstract":"<p><p>Laughter is a universal social signal and a defining clinical sign of various neurological disorders. Yet, its neural orchestration remains elusive, due in part to the challenge of reproducing its spontaneous nature in the laboratory. In this review, we showcase how recent invasive investigations-from direct electrical stimulation to intracranial recordings-unveil the underlying circuitry. We propose a dual-system framework: an evolutionarily ancient cingulo-temporal network that acts as the gateway for spontaneous, involuntary outbursts; and a lateral motor-opercular system that co-opts speech-production networks for volitional, conversational laughter. This neuroethological perspective reveals how parallel cortico-subcortical pathways drive laughter as both a primal affective signal and a sophisticated communicative tool, offering a new roadmap for understanding human social bonding and its clinical disruptions.</p>","PeriodicalId":23325,"journal":{"name":"Trends in Neurosciences","volume":" ","pages":"536-550"},"PeriodicalIF":15.7,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148309677","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Additive convergence for visuomotor decisions. 视觉运动决策的加性收敛。
IF 15.7 1区 医学
Trends in Neurosciences Pub Date : 2026-07-01 Epub Date: 2026-05-19 DOI: 10.1016/j.tins.2026.04.011
Na N Guan, Jianren Song
{"title":"Additive convergence for visuomotor decisions.","authors":"Na N Guan, Jianren Song","doi":"10.1016/j.tins.2026.04.011","DOIUrl":"10.1016/j.tins.2026.04.011","url":null,"abstract":"<p><p>In a recent study, Slangewal et al. explored principles of visuomotor decision-making in larval zebrafish. Visuomotor choices were revealed to be largely additive, integrating visual motion, luminance level, and luminance change during cue conflict. Brain-wide imaging mapped parallel feature circuits within the optic tectum that converge in the anterior hindbrain. Single-cell identity and morphology analyses refined this map, linking behavioral algorithms to candidate circuit implementations.</p>","PeriodicalId":23325,"journal":{"name":"Trends in Neurosciences","volume":" ","pages":"506-508"},"PeriodicalIF":15.7,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147975860","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
首页 上一页 下一页 尾页
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整，为了账户安全，请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
请完成安全验证×
相关产品
×
本文献相关产品
联系我们：info@booksci.cn Book学术提供免费学术资源搜索服务，方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号：604180095
Book学术官方微信
小红书