发布求助
文献互助 智能选刊 最新文献

Trends in Neurosciences最新文献

筛选
英文 中文
Subscription and Copyright Information 订阅和版权信息
IF 15.9 1区 医学
Trends in Neurosciences Pub Date : 2024-09-10 DOI: 10.1016/s0166-2236(24)00162-0
{"title":"Subscription and Copyright Information","authors":"","doi":"10.1016/s0166-2236(24)00162-0","DOIUrl":"https://doi.org/10.1016/s0166-2236(24)00162-0","url":null,"abstract":"No Abstract","PeriodicalId":23325,"journal":{"name":"Trends in Neurosciences","volume":"26 1","pages":""},"PeriodicalIF":15.9,"publicationDate":"2024-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142196473","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Behavioral neuroscience's inevitable SABV growing pains. 行为神经科学不可避免的 SABV 阵痛。
IF 14.6 1区 医学
Trends in Neurosciences Pub Date : 2024-09-01 Epub Date: 2024-07-20 DOI: 10.1016/j.tins.2024.06.007
Rebecca M Shansky
{"title":"Behavioral neuroscience's inevitable SABV growing pains.","authors":"Rebecca M Shansky","doi":"10.1016/j.tins.2024.06.007","DOIUrl":"10.1016/j.tins.2024.06.007","url":null,"abstract":"<p><p>The field of rodent behavioral neuroscience is undergoing two major sea changes: an ever-growing technological revolution, and worldwide calls to consider sex as a biological variable (SABV) in experimental design. Both have enormous potential to improve the precision and rigor with which the brain can be studied, but the convergence of these shifts in scientific practice has exposed critical limitations in classic and widely used behavioral paradigms. While our tools have advanced, our behavioral metrics - mostly developed in males and often allowing for only binary outcomes - have not. This opinion article explores how this disconnect has presented challenges for the accurate depiction and interpretation of sex differences in brain function, arguing for the expansion of current behavioral constructs to better account for behavioral diversity.</p>","PeriodicalId":23325,"journal":{"name":"Trends in Neurosciences","volume":" ","pages":"669-676"},"PeriodicalIF":14.6,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141735073","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
White matter damage and degeneration in traumatic brain injury. 脑外伤导致的白质损伤和退化。
IF 14.6 1区 医学
Trends in Neurosciences Pub Date : 2024-09-01 Epub Date: 2024-08-10 DOI: 10.1016/j.tins.2024.07.003
Regina C Armstrong, Genevieve M Sullivan, Daniel P Perl, Jessica D Rosarda, Kryslaine L Radomski
{"title":"White matter damage and degeneration in traumatic brain injury.","authors":"Regina C Armstrong, Genevieve M Sullivan, Daniel P Perl, Jessica D Rosarda, Kryslaine L Radomski","doi":"10.1016/j.tins.2024.07.003","DOIUrl":"10.1016/j.tins.2024.07.003","url":null,"abstract":"<p><p>Traumatic brain injury (TBI) is a complex condition that can resolve over time but all too often leads to persistent symptoms, and the risk of poor patient outcomes increases with aging. TBI damages neurons and long axons within white matter tracts that are critical for communication between brain regions; this causes slowed information processing and neuronal circuit dysfunction. This review focuses on white matter injury after TBI and the multifactorial processes that underlie white matter damage, potential for recovery, and progression of degeneration. A multiscale perspective across clinical and preclinical advances is presented to encourage interdisciplinary insights from whole-brain neuroimaging of white matter tracts down to cellular and molecular responses of axons, myelin, and glial cells within white matter tissue.</p>","PeriodicalId":23325,"journal":{"name":"Trends in Neurosciences","volume":" ","pages":"677-692"},"PeriodicalIF":14.6,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141914094","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Parabrachial neurons promote nociplastic pain. 胫骨旁神经元促进神经痉挛性疼痛
IF 14.6 1区 医学
Trends in Neurosciences Pub Date : 2024-09-01 Epub Date: 2024-08-14 DOI: 10.1016/j.tins.2024.07.002
Richard D Palmiter
{"title":"Parabrachial neurons promote nociplastic pain.","authors":"Richard D Palmiter","doi":"10.1016/j.tins.2024.07.002","DOIUrl":"10.1016/j.tins.2024.07.002","url":null,"abstract":"<p><p>The parabrachial nucleus (PBN) in the dorsal pons responds to bodily threats and transmits alarm signals to the forebrain. Parabrachial neuron activity is enhanced during chronic pain, and inactivation of PBN neurons in mice prevents the establishment of neuropathic, chronic pain symptoms. Chemogenetic or optogenetic activation of all glutamatergic neurons in the PBN, or just the subpopulation that expresses the Calca gene, is sufficient to establish pain phenotypes, including long-lasting tactile allodynia, that scale with the extent of stimulation, thereby promoting nociplastic pain, defined as diffuse pain without tissue inflammation or nerve injury. This review focuses on the role(s) of molecularly defined PBN neurons and the downstream nodes in the brain that contribute to establishing nociplastic pain.</p>","PeriodicalId":23325,"journal":{"name":"Trends in Neurosciences","volume":" ","pages":"722-735"},"PeriodicalIF":14.6,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141989009","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
From synapse to sensation: the role of circTulp4. 从突触到感觉：circTulp4 的作用。
IF 14.6 1区 医学
Trends in Neurosciences Pub Date : 2024-09-01 Epub Date: 2024-08-26 DOI: 10.1016/j.tins.2024.08.005
Juli Wang, Irina Voineagu
{"title":"From synapse to sensation: the role of circTulp4.","authors":"Juli Wang, Irina Voineagu","doi":"10.1016/j.tins.2024.08.005","DOIUrl":"10.1016/j.tins.2024.08.005","url":null,"abstract":"<p><p>Recent work by Giusti and colleagues showed that circTulp4 modulates excitatory synaptic strength. Knocking down circTulp4 disrupts the excitation-inhibition (E/I) balance in mice and leads to hypersensitivity toward aversive stimuli. These observations update our appreciation of the functions of circular (circ)RNA in the nervous system and their potential implication in neurodevelopmental and neuropsychiatric disorders.</p>","PeriodicalId":23325,"journal":{"name":"Trends in Neurosciences","volume":" ","pages":"665-666"},"PeriodicalIF":14.6,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142081724","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Multiple faces of anxiety: a frontal lobe perspective. 焦虑的多重面孔：额叶视角。
IF 14.6 1区 医学
Trends in Neurosciences Pub Date : 2024-09-01 Epub Date: 2024-08-09 DOI: 10.1016/j.tins.2024.07.001
Angela C Roberts, Kevin G Mulvihill
{"title":"Multiple faces of anxiety: a frontal lobe perspective.","authors":"Angela C Roberts, Kevin G Mulvihill","doi":"10.1016/j.tins.2024.07.001","DOIUrl":"10.1016/j.tins.2024.07.001","url":null,"abstract":"<p><p>Marked dysregulation of the human prefrontal cortex (PFC) and anterior cingulate cortex (ACC) characterises a variety of anxiety disorders, and its amelioration is a key feature of treatment success. Overall treatment response, however, is highly variable, and about a third of patients are resistant to treatment. In this review we hypothesise that a major contributor to this variation in treatment response are the multiple faces of anxiety induced by distinct forms of frontal cortex dysregulation. Comparison of findings from humans and non-human primates reveals marked similarity in the functional organisation of threat regulation across the frontal lobes. This organisation is discussed in relation to the 'predatory imminence continuum' model of threat and the differential engagement of executive functions at the core of both emotion generation and regulation strategies.</p>","PeriodicalId":23325,"journal":{"name":"Trends in Neurosciences","volume":" ","pages":"708-721"},"PeriodicalIF":14.6,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141914093","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Evolving insights into erythrocytes in synucleinopathies. 对突触核蛋白病中红细胞的认识不断发展。
IF 14.6 1区 医学
Trends in Neurosciences Pub Date : 2024-09-01 Epub Date: 2024-07-23 DOI: 10.1016/j.tins.2024.06.005
Ying Yang, Xiaoqian Nie, Yajie Wang, Jie Sun, Xiaofei Gao, Jing Zhang
{"title":"Evolving insights into erythrocytes in synucleinopathies.","authors":"Ying Yang, Xiaoqian Nie, Yajie Wang, Jie Sun, Xiaofei Gao, Jing Zhang","doi":"10.1016/j.tins.2024.06.005","DOIUrl":"10.1016/j.tins.2024.06.005","url":null,"abstract":"<p><p>Synucleinopathies, including Parkinson's disease (PD), multiple system atrophy (MSA), and dementia with Lewy bodies (DLB), are characterized by neuronal loss accompanied by α-synuclein (α-syn) accumulation in the brain. While research conventionally focused on brain pathology, there is growing interest in peripheral alterations. Erythrocytes, which are rich in α-syn, have emerged as a compelling site for synucleinopathies-related alterations. Erythrocyte-derived extracellular vesicles (EVs), containing pathological α-syn species, can traverse the blood-brain barrier (BBB) under certain conditions and the gastrointestinal tract, where α-syn and gut microbiota interact extensively. This review explores the accumulating evidence of erythrocyte involvement in synucleinopathies, as well as their potential in disease pathogenesis and diagnosis. Given their unique properties, erythrocytes and erythrocyte-derived EVs may also serve as an ideal therapeutic platform for treating synucleinopathies and beyond.</p>","PeriodicalId":23325,"journal":{"name":"Trends in Neurosciences","volume":" ","pages":"693-707"},"PeriodicalIF":14.6,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141752879","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Early neuronal inhibition sculpts adult cortical interhemispheric connectivity. 早期的神经元抑制会形成成人大脑皮层半球间的连接。
IF 14.6 1区 医学
Trends in Neurosciences Pub Date : 2024-09-01 Epub Date: 2024-08-13 DOI: 10.1016/j.tins.2024.08.002
Míriam Javier-Torrent, Antonela Bonafina, Laurent Nguyen
{"title":"Early neuronal inhibition sculpts adult cortical interhemispheric connectivity.","authors":"Míriam Javier-Torrent, Antonela Bonafina, Laurent Nguyen","doi":"10.1016/j.tins.2024.08.002","DOIUrl":"10.1016/j.tins.2024.08.002","url":null,"abstract":"<p><p>The maturation of cerebral cortical networks during early life involves a major reorganization of long-range axonal connections. In a recent study, Bragg-Gonzalo, Aguilera, et al. discovered that in mice, the interhemispheric connections sent by S1L4 callosal projection neurons are pruned via the tight control of their ipsilateral synaptic integration, which relies on the early activity of specific interneurons.</p>","PeriodicalId":23325,"journal":{"name":"Trends in Neurosciences","volume":" ","pages":"667-668"},"PeriodicalIF":14.6,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141983318","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Tools to study neural and glioma stem cell quiescence. 研究神经和胶质瘤干细胞静止期的工具。
IF 14.6 1区 医学
Trends in Neurosciences Pub Date : 2024-09-01 Epub Date: 2024-08-26 DOI: 10.1016/j.tins.2024.07.004
Dana Friess, Stephanie Brauer, Anni Pöysti, Chandra Choudhury, Lachlan Harris
{"title":"Tools to study neural and glioma stem cell quiescence.","authors":"Dana Friess, Stephanie Brauer, Anni Pöysti, Chandra Choudhury, Lachlan Harris","doi":"10.1016/j.tins.2024.07.004","DOIUrl":"10.1016/j.tins.2024.07.004","url":null,"abstract":"<p><p>Quiescence is a prolonged but reversible state of cell-cycle arrest that is an adaptive feature of most adult stem cell populations. In the brain, quiescence helps to protect adult neural stem cells from stress and supports lifelong neurogenesis. Unfortunately however, entry into a quiescent or a slow-cycling state is also a malignant feature of brain cancer stem cells. In glioblastoma, where the process has been best characterised, quiescent glioma stem cells preferentially survive chemoradiation, and after therapy, reactivate to regrow the tumour and drive recurrence. In this Review, we discuss the in vitro and in vivo models that have been developed for studying neural stem cell quiescence and how these tools may be used to deepen biological understanding and to develop novel therapies targeting quiescent glioma stem cells.</p>","PeriodicalId":23325,"journal":{"name":"Trends in Neurosciences","volume":" ","pages":"736-748"},"PeriodicalIF":14.6,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142081725","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Advisory Board and Contents 咨询委员会和内容
IF 15.9 1区 医学
Trends in Neurosciences Pub Date : 2024-08-13 DOI: 10.1016/s0166-2236(24)00132-2
{"title":"Advisory Board and Contents","authors":"","doi":"10.1016/s0166-2236(24)00132-2","DOIUrl":"https://doi.org/10.1016/s0166-2236(24)00132-2","url":null,"abstract":"No Abstract","PeriodicalId":23325,"journal":{"name":"Trends in Neurosciences","volume":"9 1","pages":""},"PeriodicalIF":15.9,"publicationDate":"2024-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142196530","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
首页 上一页 下一页 尾页
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整，为了账户安全，请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
请完成安全验证×
相关产品
×
本文献相关产品
联系我们：info@booksci.cn Book学术提供免费学术资源搜索服务，方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号：481959085
Book学术官方微信