PDZD8 orchestrates synaptic remodeling through autophagy.

IF 14.6 1区医学 Q1 NEUROSCIENCES

Trends in Neurosciences Pub Date : 2025-06-05 DOI:10.1016/j.tins.2025.05.003

Xueying Peng, Yixian Cui

引用次数: 0

Abstract

In a recent study, Thakur and O'Connor-Giles identified PDZD8 as a novel regulator of activity-dependent synaptic growth in Drosophila. Localized at endoplasmic reticulum (ER)-late endosome/lysosome (LEL) membrane contact sites (MCSs), PDZD8 promotes autophagy by coupling lipid transfer to autolysosome maturation to drive synaptic bouton formation, providing in vivo evidence that autophagy contributes directly to synaptic remodeling.

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PDZD8通过自噬协调突触重塑。

在最近的一项研究中，Thakur和O'Connor-Giles发现PDZD8是果蝇活动依赖性突触生长的一种新型调节剂。PDZD8定位于内质网(ER)-内溶体/溶酶体（LEL）膜接触位点（MCSs），通过脂质传递耦合自噬体成熟来促进自噬，从而驱动突触扣形成，为自噬直接促进突触重塑提供了体内证据。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Trends in Neurosciences 医学-神经科学

CiteScore

26.50

自引率

1.30%

发文量

123

审稿时长

6-12 weeks

期刊介绍： For over four decades, Trends in Neurosciences (TINS) has been a prominent source of inspiring reviews and commentaries across all disciplines of neuroscience. TINS is a monthly, peer-reviewed journal, and its articles are curated by the Editor and authored by leading researchers in their respective fields. The journal communicates exciting advances in brain research, serves as a voice for the global neuroscience community, and highlights the contribution of neuroscientific research to medicine and society.