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Neuroimmune interactions in the development and chronification of migraine headache 偏头痛发展和慢性化过程中的神经免疫相互作用
IF 15.9 1区 医学
Trends in Neurosciences Pub Date : 2024-09-12 DOI: 10.1016/j.tins.2024.08.009
Jintao Zhang, Roli Simoes, Tingting Guo, Yu-Qing Cao
{"title":"Neuroimmune interactions in the development and chronification of migraine headache","authors":"Jintao Zhang, Roli Simoes, Tingting Guo, Yu-Qing Cao","doi":"10.1016/j.tins.2024.08.009","DOIUrl":"https://doi.org/10.1016/j.tins.2024.08.009","url":null,"abstract":"<p>Migraine is highly prevalent and debilitating. The persistent headaches in this condition are thought to arise from the activation and sensitization of the trigeminovascular pathway. Both clinical and animal model studies have suggested that neuroimmune interactions contribute to the pathophysiology of migraine headache. In this review, we first summarize the findings from human studies implicating the dysregulation of the immune system in migraine, including genetic analyses, measurement of circulatory factors, and neuroimaging data. We next discuss recent advances from rodent studies aimed at elucidating the neuroimmune interactions that manifest at various levels of the trigeminovascular pathway and lead to the recruitment of innate and adaptive immune cells as well as immunocompetent glial cells. These cells reciprocally modulate neuronal activity via multiple pro- and anti-inflammatory mediators, thereby regulating peripheral and central sensitization. Throughout the discussions, we highlight the potential clinical and translational implications of the findings.</p>","PeriodicalId":23325,"journal":{"name":"Trends in Neurosciences","volume":null,"pages":null},"PeriodicalIF":15.9,"publicationDate":"2024-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142196527","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Getting stress-related disorders under control: the untapped potential of neurofeedback 控制与压力有关的失调：神经反馈尚未开发的潜力
IF 15.9 1区 医学
Trends in Neurosciences Pub Date : 2024-09-10 DOI: 10.1016/j.tins.2024.08.007
Florian Krause, David E.J. Linden, Erno J. Hermans
{"title":"Getting stress-related disorders under control: the untapped potential of neurofeedback","authors":"Florian Krause, David E.J. Linden, Erno J. Hermans","doi":"10.1016/j.tins.2024.08.007","DOIUrl":"https://doi.org/10.1016/j.tins.2024.08.007","url":null,"abstract":"<p>Stress-related disorders are among the biggest global health challenges. Despite significant progress in understanding their neurocognitive basis, the promise of applying insights from fundamental research to prevention and treatment remains largely unfulfilled. We argue that neurofeedback – a method for training voluntary control over brain activity – has the potential to fill this translational gap. We provide a contemporary perspective on neurofeedback as endogenous neuromodulation that can target complex brain network dynamics, is transferable to real-world scenarios outside a laboratory or treatment facility, can be trained prospectively, and is individually adaptable. This makes neurofeedback a prime candidate for a personalized preventive neuroscience-based intervention strategy that focuses on the ecological momentary neuromodulation of stress-related brain networks in response to actual stressors in real life.</p>","PeriodicalId":23325,"journal":{"name":"Trends in Neurosciences","volume":null,"pages":null},"PeriodicalIF":15.9,"publicationDate":"2024-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142196529","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Advisory Board and Contents 咨询委员会和内容
IF 15.9 1区 医学
Trends in Neurosciences Pub Date : 2024-09-10 DOI: 10.1016/s0166-2236(24)00159-0
{"title":"Advisory Board and Contents","authors":"","doi":"10.1016/s0166-2236(24)00159-0","DOIUrl":"https://doi.org/10.1016/s0166-2236(24)00159-0","url":null,"abstract":"No Abstract","PeriodicalId":23325,"journal":{"name":"Trends in Neurosciences","volume":null,"pages":null},"PeriodicalIF":15.9,"publicationDate":"2024-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142196528","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Subscription and Copyright Information 订阅和版权信息
IF 15.9 1区 医学
Trends in Neurosciences Pub Date : 2024-09-10 DOI: 10.1016/s0166-2236(24)00162-0
{"title":"Subscription and Copyright Information","authors":"","doi":"10.1016/s0166-2236(24)00162-0","DOIUrl":"https://doi.org/10.1016/s0166-2236(24)00162-0","url":null,"abstract":"No Abstract","PeriodicalId":23325,"journal":{"name":"Trends in Neurosciences","volume":null,"pages":null},"PeriodicalIF":15.9,"publicationDate":"2024-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142196473","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Object-oriented olfaction: challenges for chemosensation and for chemosensory research. 面向对象的嗅觉：化学感觉和化学感觉研究面临的挑战。
IF 14.6 1区 医学
Trends in Neurosciences Pub Date : 2024-09-07 DOI: 10.1016/j.tins.2024.08.008
Dan Rokni, Yoram Ben-Shaul
{"title":"Object-oriented olfaction: challenges for chemosensation and for chemosensory research.","authors":"Dan Rokni, Yoram Ben-Shaul","doi":"10.1016/j.tins.2024.08.008","DOIUrl":"https://doi.org/10.1016/j.tins.2024.08.008","url":null,"abstract":"<p><p>Many animal species use olfaction to extract information about objects in their environment. Yet, the specific molecular signature that any given object emits varies due to various factors. Here, we detail why such variability makes chemosensory-mediated object recognition such a hard problem, and we propose that a major function of the elaborate chemosensory network is to overcome it. We describe previous work addressing different elements of the problem and outline future research directions that we consider essential for a full understanding of object-oriented olfaction. In particular, we call for extensive representation of olfactory object variability in chemical, behavioral, and electrophysiological analyses. While written with an emphasis on macrosmatic mammalian species, our arguments apply to all organisms that employ chemosensation to navigate complex environments.</p>","PeriodicalId":23325,"journal":{"name":"Trends in Neurosciences","volume":null,"pages":null},"PeriodicalIF":14.6,"publicationDate":"2024-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142155053","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Human-derived monoclonal autoantibodies as interrogators of cellular proteotypes in the brain. 人源单克隆自身抗体作为脑细胞蛋白型的询问因子。
IF 14.6 1区 医学
Trends in Neurosciences Pub Date : 2024-09-05 DOI: 10.1016/j.tins.2024.08.004
Matthew L Baum, Christopher M Bartley
{"title":"Human-derived monoclonal autoantibodies as interrogators of cellular proteotypes in the brain.","authors":"Matthew L Baum, Christopher M Bartley","doi":"10.1016/j.tins.2024.08.004","DOIUrl":"https://doi.org/10.1016/j.tins.2024.08.004","url":null,"abstract":"<p><p>A major aim of neuroscience is to identify and model the functional properties of neural cells whose dysfunction underlie neuropsychiatric illness. In this article, we propose that human-derived monoclonal autoantibodies (HD-mAbs) are well positioned to selectively target and manipulate neural subpopulations as defined by their protein expression; that is, cellular proteotypes. Recent technical advances allow for efficient cloning of autoantibodies from neuropsychiatric patients. These HD-mAbs can be introduced into animal models to gain biological and pathobiological insights about neural proteotypes of interest. Protein engineering can be used to modify, enhance, silence, or confer new functional properties to native HD-mAbs, thereby enhancing their versatility. Finally, we discuss the challenges and limitations confronting HD-mAbs as experimental research tools for neuroscience.</p>","PeriodicalId":23325,"journal":{"name":"Trends in Neurosciences","volume":null,"pages":null},"PeriodicalIF":14.6,"publicationDate":"2024-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142146397","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Unweaving type I interferons in age-related neuroinflammation. 解开 I 型干扰素在与年龄相关的神经炎症中的作用。
IF 14.6 1区 医学
Trends in Neurosciences Pub Date : 2024-09-04 DOI: 10.1016/j.tins.2024.08.014
David P J Hunt, Markus J Hofer
{"title":"Unweaving type I interferons in age-related neuroinflammation.","authors":"David P J Hunt, Markus J Hofer","doi":"10.1016/j.tins.2024.08.014","DOIUrl":"https://doi.org/10.1016/j.tins.2024.08.014","url":null,"abstract":"<p><p>Neuroinflammation is a feature of both neurodegenerative disease and normal brain aging. The roles of type I interferon (IFN-I) in the aged brain are incompletely understood. A recent article by Roy et al. reveals pervasive IFN-I activity in normal mouse brain aging, and highlights the importance of microglial IFN-I signaling in neuroinflammation.</p>","PeriodicalId":23325,"journal":{"name":"Trends in Neurosciences","volume":null,"pages":null},"PeriodicalIF":14.6,"publicationDate":"2024-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142141214","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
When sensory input meets spontaneous brain activity. 当感官输入与大脑自发活动相遇时。
IF 14.6 1区 医学
Trends in Neurosciences Pub Date : 2024-08-31 DOI: 10.1016/j.tins.2024.08.010
Natalia Zaretskaya
{"title":"When sensory input meets spontaneous brain activity.","authors":"Natalia Zaretskaya","doi":"10.1016/j.tins.2024.08.010","DOIUrl":"https://doi.org/10.1016/j.tins.2024.08.010","url":null,"abstract":"<p><p>A recent study by Wu, Podvalny, and colleagues investigated how ongoing spontaneous brain activity interacts with sensory input and shapes conscious perception. It reports diverse effects of prestimulus activity in several key networks, revealing new roles of the prefrontal cortex and the default mode network in perception and consciousness.</p>","PeriodicalId":23325,"journal":{"name":"Trends in Neurosciences","volume":null,"pages":null},"PeriodicalIF":14.6,"publicationDate":"2024-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142112396","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Neural adaptation to changes in self-voice during puberty. 青春期自我声音变化的神经适应。
IF 14.6 1区 医学
Trends in Neurosciences Pub Date : 2024-08-29 DOI: 10.1016/j.tins.2024.08.001
Ana P Pinheiro, Jean-Julien Aucouturier, Sonja A Kotz
{"title":"Neural adaptation to changes in self-voice during puberty.","authors":"Ana P Pinheiro, Jean-Julien Aucouturier, Sonja A Kotz","doi":"10.1016/j.tins.2024.08.001","DOIUrl":"https://doi.org/10.1016/j.tins.2024.08.001","url":null,"abstract":"<p><p>The human voice is a potent social signal and a distinctive marker of individual identity. As individuals go through puberty, their voices undergo acoustic changes, setting them apart from others. In this article, we propose that hormonal fluctuations in conjunction with morphological vocal tract changes during puberty establish a sensitive developmental phase that affects the monitoring of the adolescent voice and, specifically, self-other distinction. Furthermore, the protracted maturation of brain regions responsible for voice processing, coupled with the dynamically evolving social environment of adolescents, likely disrupts a clear differentiation of the self-voice from others' voices. This socioneuroendocrine framework offers a holistic understanding of voice monitoring during adolescence.</p>","PeriodicalId":23325,"journal":{"name":"Trends in Neurosciences","volume":null,"pages":null},"PeriodicalIF":14.6,"publicationDate":"2024-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142112395","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
From synapse to sensation: the role of circTulp4. 从突触到感觉：circTulp4 的作用。
IF 14.6 1区 医学
Trends in Neurosciences Pub Date : 2024-08-26 DOI: 10.1016/j.tins.2024.08.005
Juli Wang, Irina Voineagu
{"title":"From synapse to sensation: the role of circTulp4.","authors":"Juli Wang, Irina Voineagu","doi":"10.1016/j.tins.2024.08.005","DOIUrl":"https://doi.org/10.1016/j.tins.2024.08.005","url":null,"abstract":"<p><p>Recent work by Giusti and colleagues showed that circTulp4 modulates excitatory synaptic strength. Knocking down circTulp4 disrupts the excitation-inhibition (E/I) balance in mice and leads to hypersensitivity toward aversive stimuli. These observations update our appreciation of the functions of circular (circ)RNA in the nervous system and their potential implication in neurodevelopmental and neuropsychiatric disorders.</p>","PeriodicalId":23325,"journal":{"name":"Trends in Neurosciences","volume":null,"pages":null},"PeriodicalIF":14.6,"publicationDate":"2024-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142081724","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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