发布求助
文献互助 智能选刊 最新文献

Trends in Neurosciences最新文献

筛选
英文 中文
Establishing functionally segregated dopaminergic circuits.
IF 14.6 1区 医学
Trends in Neurosciences Pub Date : 2025-01-24 DOI: 10.1016/j.tins.2024.12.002
Akiko Terauchi, Erin M Johnson-Venkatesh, Hisashi Umemori
{"title":"Establishing functionally segregated dopaminergic circuits.","authors":"Akiko Terauchi, Erin M Johnson-Venkatesh, Hisashi Umemori","doi":"10.1016/j.tins.2024.12.002","DOIUrl":"https://doi.org/10.1016/j.tins.2024.12.002","url":null,"abstract":"<p><p>Despite accounting for only ~0.001% of all neurons in the human brain, midbrain dopaminergic neurons control numerous behaviors and are associated with many neuropsychiatric disorders that affect our physical and mental health. Dopaminergic neurons form various anatomically and functionally segregated pathways. Having such defined dopaminergic pathways is key to controlling varied sets of brain functions; therefore, segregated dopaminergic pathways must be properly and uniquely formed during development. How are these segregated pathways established? The three key developmental stages that dopaminergic neurons go through are cell migration, axon guidance, and synapse formation. In each stage, dopaminergic neurons and their processes receive unique molecular cues to guide the formation of specific dopaminergic pathways. Here, we outline the molecular mechanisms underlying the establishment of segregated dopaminergic pathways during each developmental stage in the mouse brain, focusing on the formation of the three major dopaminergic pathways: the nigrostriatal, mesolimbic, and mesocortical pathways. We propose that multiple stage-specific molecular gradients cooperate to establish functionally segregated dopaminergic circuits.</p>","PeriodicalId":23325,"journal":{"name":"Trends in Neurosciences","volume":" ","pages":""},"PeriodicalIF":14.6,"publicationDate":"2025-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143042311","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Coordinating the energetic strategy of glia and neurons for memory.
IF 14.6 1区 医学
Trends in Neurosciences Pub Date : 2025-01-22 DOI: 10.1016/j.tins.2025.01.001
Hannah Shoenhard, Amita Sehgal
{"title":"Coordinating the energetic strategy of glia and neurons for memory.","authors":"Hannah Shoenhard, Amita Sehgal","doi":"10.1016/j.tins.2025.01.001","DOIUrl":"https://doi.org/10.1016/j.tins.2025.01.001","url":null,"abstract":"<p><p>Memory consolidation requires rapid energy supply to neurons. In a recent study, Francés et al. revealed the signal by which a neuron commands glia to limit fatty acid synthesis in favor of metabolite export during memory formation in Drosophila melanogaster. This mechanism coordinates just-in-time glial energy delivery in response to dynamic neuronal needs.</p>","PeriodicalId":23325,"journal":{"name":"Trends in Neurosciences","volume":" ","pages":""},"PeriodicalIF":14.6,"publicationDate":"2025-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143029736","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Tuning synapse strength by nanocolumn plasticity.
IF 14.6 1区 医学
Trends in Neurosciences Pub Date : 2025-01-22 DOI: 10.1016/j.tins.2024.12.009
Na Xu, Si-Yu Chen, Ai-Hui Tang
{"title":"Tuning synapse strength by nanocolumn plasticity.","authors":"Na Xu, Si-Yu Chen, Ai-Hui Tang","doi":"10.1016/j.tins.2024.12.009","DOIUrl":"https://doi.org/10.1016/j.tins.2024.12.009","url":null,"abstract":"<p><p>The precise organization of the complex set of synaptic proteins at the nanometer scale is crucial for synaptic transmission. At the heart of this nanoscale architecture lies the nanocolumn. This aligns presynaptic neurotransmitter release with a high local density of postsynaptic receptor channels, thereby optimizing synaptic strength. Although synapses exhibit diverse protein compositions and nanoscale organizations, the role of structural diversity in the notable differences observed in synaptic physiology remains poorly understood. In this review we examine the current literature on the molecular mechanisms underlying the formation and maintenance of nanocolumns, as well as their role in modulating various aspects of synaptic transmission. We also discuss how the reorganization of nanocolumns contributes to functional dynamics in both synaptic plasticity and pathology.</p>","PeriodicalId":23325,"journal":{"name":"Trends in Neurosciences","volume":" ","pages":""},"PeriodicalIF":14.6,"publicationDate":"2025-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143029765","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Mechanistic insights into chemotherapy-induced circadian disruption using rodent models.
IF 14.6 1区 医学
Trends in Neurosciences Pub Date : 2025-01-22 DOI: 10.1016/j.tins.2024.12.011
Zoe M Tapp, Amiya K Ghosh, Karl H Obrietan, Leah M Pyter
{"title":"Mechanistic insights into chemotherapy-induced circadian disruption using rodent models.","authors":"Zoe M Tapp, Amiya K Ghosh, Karl H Obrietan, Leah M Pyter","doi":"10.1016/j.tins.2024.12.011","DOIUrl":"https://doi.org/10.1016/j.tins.2024.12.011","url":null,"abstract":"<p><p>Chemotherapy treatment can significantly increase the survival of patients with cancer, but it also causes collateral damage in the body that can lead to treatment dose reductions and can reduce patient quality of life. One understudied side effect of chemotherapy is circadian disruption, which is associated with lasting biological and behavioral toxicities. Mechanisms of how chemotherapy alters circadian rhythms remain largely unknown, although leveraging rodent models may provide insights into causes and consequences of this disruption. Here, we review physiological, molecular, and behavioral evidence of central and peripheral circadian disruption in various rodent models of chemotherapy and discuss possible mechanisms driving these circadian disruptions. Overall, restoring circadian rhythms following treatment-induced disruptions may be a novel target by which to improve the health and quality of life of survivors.</p>","PeriodicalId":23325,"journal":{"name":"Trends in Neurosciences","volume":" ","pages":""},"PeriodicalIF":14.6,"publicationDate":"2025-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143024889","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Making sense of vertebrate senses from a neural crest and cranial placode evo-devo perspective.
IF 14.6 1区 医学
Trends in Neurosciences Pub Date : 2025-01-22 DOI: 10.1016/j.tins.2024.12.008
Brittany M Edens, Marianne E Bronner
{"title":"Making sense of vertebrate senses from a neural crest and cranial placode evo-devo perspective.","authors":"Brittany M Edens, Marianne E Bronner","doi":"10.1016/j.tins.2024.12.008","DOIUrl":"https://doi.org/10.1016/j.tins.2024.12.008","url":null,"abstract":"<p><p>The evolution of vertebrates from protochordate ancestors marked the beginning of the gradual transition to predatory lifestyles. Enabled by the acquisition of multipotent neural crest and cranial placode cell populations, vertebrates developed an elaborate peripheral nervous system, equipped with paired sense organs, which aided in adaptive behaviors and ultimately, successful colonization of diverse environmental niches. Underpinning the enduring success of vertebrates is the highly adaptable nature of the peripheral nervous system, which is enabled by the exceptional malleability of the neural crest and placode developmental programs. Here, we explore the embryonic origins of the vertebrate senses from the neural crest and cranial placodes and discuss the evolutionary trajectory of the senses in the context of adaptation to novel environments.</p>","PeriodicalId":23325,"journal":{"name":"Trends in Neurosciences","volume":" ","pages":""},"PeriodicalIF":14.6,"publicationDate":"2025-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143029760","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Elucidating hemodynamics and neuro-glio-vascular signaling using rodent fMRI.
IF 14.6 1区 医学
Trends in Neurosciences Pub Date : 2025-01-21 DOI: 10.1016/j.tins.2024.12.010
Xiaoqing Alice Zhou, Yuanyuan Jiang, Lidia Gomez-Cid, Xin Yu
{"title":"Elucidating hemodynamics and neuro-glio-vascular signaling using rodent fMRI.","authors":"Xiaoqing Alice Zhou, Yuanyuan Jiang, Lidia Gomez-Cid, Xin Yu","doi":"10.1016/j.tins.2024.12.010","DOIUrl":"https://doi.org/10.1016/j.tins.2024.12.010","url":null,"abstract":"<p><p>Despite extensive functional mapping studies using rodent functional magnetic resonance imaging (fMRI), interpreting the fMRI signals in relation to their neuronal origins remains challenging due to the hemodynamic nature of the response. Ultra high-resolution rodent fMRI, beyond merely enhancing spatial specificity, has revealed vessel-specific hemodynamic responses, highlighting the distinct contributions of intracortical arterioles and venules to fMRI signals. This 'single-vessel' fMRI approach shifts the paradigm of rodent fMRI, enabling its integration with other neuroimaging modalities to investigate neuro-glio-vascular (NGV) signaling underlying a variety of brain dynamics. Here, we review the emerging trend of combining multimodal fMRI with opto/chemogenetic neuromodulation and genetically encoded biosensors for cellular and circuit-specific recording, offering unprecedented opportunities for cross-scale brain dynamic mapping in rodent models.</p>","PeriodicalId":23325,"journal":{"name":"Trends in Neurosciences","volume":" ","pages":""},"PeriodicalIF":14.6,"publicationDate":"2025-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143024883","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Metacognition in the listening brain.
IF 14.6 1区 医学
Trends in Neurosciences Pub Date : 2025-01-21 DOI: 10.1016/j.tins.2024.12.007
Jonas Obleser
{"title":"Metacognition in the listening brain.","authors":"Jonas Obleser","doi":"10.1016/j.tins.2024.12.007","DOIUrl":"https://doi.org/10.1016/j.tins.2024.12.007","url":null,"abstract":"<p><p>How do you know you have heard right? Metacognition, the ability to assess and monitor one's own cognitive state, is key to understanding human communication in complex environments. However, the foundational role of metacognition in hearing and communication is only beginning to be explored, and the neuroscience behind it is an emerging field: how does confidence express in neural dynamics of the listening brain? What is known about auditory metaperceptual alterations as a hallmark phenomenon in psychosis, dementia, or hearing loss? Building on Bayesian ideas of auditory perception and auditory neuroscience, 'meta-listening' offers a framework for more comprehensive research into how metacognition in humans and non-humans shapes the listening brain.</p>","PeriodicalId":23325,"journal":{"name":"Trends in Neurosciences","volume":" ","pages":""},"PeriodicalIF":14.6,"publicationDate":"2025-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143024892","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Neocortical somatostatin neuron diversity in cognition and learning. 新皮质生长抑素神经元在认知和学习中的多样性。
IF 14.6 1区 医学
Trends in Neurosciences Pub Date : 2025-01-16 DOI: 10.1016/j.tins.2024.12.004
Eunsol Park, Matthew B Mosso, Alison L Barth
{"title":"Neocortical somatostatin neuron diversity in cognition and learning.","authors":"Eunsol Park, Matthew B Mosso, Alison L Barth","doi":"10.1016/j.tins.2024.12.004","DOIUrl":"https://doi.org/10.1016/j.tins.2024.12.004","url":null,"abstract":"<p><p>Somatostatin-expressing (SST) neurons are a major class of electrophysiologically and morphologically distinct inhibitory cells in the mammalian neocortex. Transcriptomic data suggest that this class can be divided into multiple subtypes that are correlated with morpho-electric properties. At the same time, availability of transgenic tools to identify and record from SST neurons in awake, behaving mice has stimulated insights about their response properties and computational function. Neocortical SST neurons are regulated by sleep and arousal, attention, and novelty detection, and show marked response plasticity during learning. Recent studies suggest that subtype-specific analysis of SST neurons may be critical for understanding their complex roles in cortical function. In this review, we discuss and synthesize recent advances in understanding the diversity, circuit integration, and functional properties of this important group of GABAergic neurons.</p>","PeriodicalId":23325,"journal":{"name":"Trends in Neurosciences","volume":" ","pages":""},"PeriodicalIF":14.6,"publicationDate":"2025-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143012340","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Decoding the rhythmic representation and communication of visual contents. 解码视觉内容的节奏表现与传播。
IF 14.6 1区 医学
Trends in Neurosciences Pub Date : 2025-01-15 DOI: 10.1016/j.tins.2024.12.005
Rico Stecher, Radoslaw Martin Cichy, Daniel Kaiser
{"title":"Decoding the rhythmic representation and communication of visual contents.","authors":"Rico Stecher, Radoslaw Martin Cichy, Daniel Kaiser","doi":"10.1016/j.tins.2024.12.005","DOIUrl":"https://doi.org/10.1016/j.tins.2024.12.005","url":null,"abstract":"<p><p>Rhythmic neural activity is considered essential for adaptively modulating responses in the visual system. In this opinion article we posit that visual brain rhythms also serve a key function in the representation and communication of visual contents. Collating a set of recent studies that used multivariate decoding methods on rhythmic brain signals, we highlight such rhythmic content representations in visual perception, imagery, and prediction. We argue that characterizing representations across frequency bands allows researchers to elegantly disentangle content transfer in feedforward and feedback directions. We further propose that alpha dynamics are central to content-specific feedback propagation in the visual system. We conclude that considering rhythmic content codes is pivotal for understanding information coding in vision and beyond.</p>","PeriodicalId":23325,"journal":{"name":"Trends in Neurosciences","volume":" ","pages":""},"PeriodicalIF":14.6,"publicationDate":"2025-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143012337","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
CK2-dependent SK channel dysfunction as contributor to neuronal hyperexcitability in Alzheimer's disease. ck2依赖性SK通道功能障碍是阿尔茨海默病中神经元高兴奋性的贡献者。
IF 14.6 1区 医学
Trends in Neurosciences Pub Date : 2025-01-04 DOI: 10.1016/j.tins.2024.12.006
Xiaojie Wei, Binggui Sun
{"title":"CK2-dependent SK channel dysfunction as contributor to neuronal hyperexcitability in Alzheimer's disease.","authors":"Xiaojie Wei, Binggui Sun","doi":"10.1016/j.tins.2024.12.006","DOIUrl":"https://doi.org/10.1016/j.tins.2024.12.006","url":null,"abstract":"<p><p>Neuronal hyperexcitability in the cortex and hippocampus represents an early event in Alzheimer's disease (AD). In a recent study, Blankenship and colleagues reported that in a mouse of AD, ventral tegmental area (VTA) dopamine neurons are also hyperexcitable, and this hyperexcitability is due to casein kinase 2 (CK2)-dependent SK channel dysfunction, adding new insights into the underlying mechanisms of aberrant neuronal properties in AD.</p>","PeriodicalId":23325,"journal":{"name":"Trends in Neurosciences","volume":" ","pages":""},"PeriodicalIF":14.6,"publicationDate":"2025-01-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142932789","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
下一页 尾页
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整，为了账户安全，请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
请完成安全验证×
相关产品
×
本文献相关产品
联系我们：info@booksci.cn Book学术提供免费学术资源搜索服务，方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号：481959085
Book学术官方微信