Trends in Neurosciences最新文献

筛选
英文 中文
The claustrum and synchronized brain states. 磁鼓与大脑同步状态
IF 14.6 1区 医学
Trends in Neurosciences Pub Date : 2024-11-01 DOI: 10.1016/j.tins.2024.10.003
Alison D Do, Coline Portet, Romain Goutagny, Jesse Jackson
{"title":"The claustrum and synchronized brain states.","authors":"Alison D Do, Coline Portet, Romain Goutagny, Jesse Jackson","doi":"10.1016/j.tins.2024.10.003","DOIUrl":"https://doi.org/10.1016/j.tins.2024.10.003","url":null,"abstract":"<p><p>Cortical activity is constantly fluctuating between distinct spatiotemporal activity patterns denoted by changes in brain state. States of cortical desynchronization arise during motor generation, increased attention, and high cognitive load. Synchronized brain states comprise spatially widespread, coordinated low-frequency neural activity during rest and sleep when disengaged from the external environment or 'offline'. The claustrum is a small subcortical structure with dense reciprocal connections with the cortex suggesting modulation by, or participation in, brain state regulation. Here, we highlight recent work suggesting that neural activity in the claustrum supports cognitive processes associated with synchronized brain states characterized by increased low-frequency network activity. As an example, we outline how claustrum activity could support episodic memory consolidation during sleep.</p>","PeriodicalId":23325,"journal":{"name":"Trends in Neurosciences","volume":null,"pages":null},"PeriodicalIF":14.6,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142564349","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Dopaminergic circuits controlling threat and safety learning. 控制威胁和安全学习的多巴胺能回路
IF 14.6 1区 医学
Trends in Neurosciences Pub Date : 2024-10-28 DOI: 10.1016/j.tins.2024.10.001
Sevil Duvarci
{"title":"Dopaminergic circuits controlling threat and safety learning.","authors":"Sevil Duvarci","doi":"10.1016/j.tins.2024.10.001","DOIUrl":"https://doi.org/10.1016/j.tins.2024.10.001","url":null,"abstract":"<p><p>The ability to learn from experience that certain cues and situations are associated with threats or safety is crucial for survival and adaptive behavior. Understanding the neural substrates of threat and safety learning has high clinical significance because deficits in these forms of learning characterize anxiety disorders. Traditionally, dopamine neurons were thought to uniformly support reward learning by signaling reward prediction errors. However, the dopamine system is functionally more diverse than was initially appreciated and is also critical for processing threat and safety. In this review, I highlight recent studies demonstrating that dopamine neurons generate prediction errors for threat and safety, and describe how dopamine projections to the amygdala, medial prefrontal cortex (mPFC), and striatum regulate associative threat and safety learning.</p>","PeriodicalId":23325,"journal":{"name":"Trends in Neurosciences","volume":null,"pages":null},"PeriodicalIF":14.6,"publicationDate":"2024-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142547690","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Principles of intensive human neuroimaging. 强化人类神经成像原理
IF 14.6 1区 医学
Trends in Neurosciences Pub Date : 2024-10-24 DOI: 10.1016/j.tins.2024.09.011
Eline R Kupers, Tomas Knapen, Elisha P Merriam, Kendrick N Kay
{"title":"Principles of intensive human neuroimaging.","authors":"Eline R Kupers, Tomas Knapen, Elisha P Merriam, Kendrick N Kay","doi":"10.1016/j.tins.2024.09.011","DOIUrl":"https://doi.org/10.1016/j.tins.2024.09.011","url":null,"abstract":"<p><p>The rise of large, publicly shared functional magnetic resonance imaging (fMRI) data sets in human neuroscience has focused on acquiring either a few hours of data on many individuals ('wide' fMRI) or many hours of data on a few individuals ('deep' fMRI). In this opinion article, we highlight an emerging approach within deep fMRI, which we refer to as 'intensive' fMRI: one that strives for extensive sampling of cognitive phenomena to support computational modeling and detailed investigation of brain function at the single voxel level. We discuss the fundamental principles, trade-offs, and practical considerations of intensive fMRI. We also emphasize that intensive fMRI does not simply mean collecting more data: it requires careful design of experiments to enable a rich hypothesis space, optimizing data quality, and strategically curating public resources to maximize community impact.</p>","PeriodicalId":23325,"journal":{"name":"Trends in Neurosciences","volume":null,"pages":null},"PeriodicalIF":14.6,"publicationDate":"2024-10-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142508799","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Retinal ganglion cell circuits and glial interactions in humans and mice. 人类和小鼠的视网膜神经节细胞回路和神经胶质相互作用。
IF 14.6 1区 医学
Trends in Neurosciences Pub Date : 2024-10-24 DOI: 10.1016/j.tins.2024.09.010
Kang-Chieh Huang, Mohamed Tawfik, Melanie A Samuel
{"title":"Retinal ganglion cell circuits and glial interactions in humans and mice.","authors":"Kang-Chieh Huang, Mohamed Tawfik, Melanie A Samuel","doi":"10.1016/j.tins.2024.09.010","DOIUrl":"https://doi.org/10.1016/j.tins.2024.09.010","url":null,"abstract":"<p><p>Retinal ganglion cells (RGCs) are the brain's gateway for vision, and their degeneration underlies several blinding diseases. RGCs interact with other neuronal cell types, microglia, and astrocytes in the retina and in the brain. Much knowledge has been gained about RGCs and glia from mice and other model organisms, often with the assumption that certain aspects of their biology may be conserved in humans. However, RGCs vary considerably between species, which could affect how they interact with their neuronal and glial partners. This review details which RGC and glial features are conserved between mice, humans, and primates, and which differ. We also discuss experimental approaches for studying human and primate RGCs. These strategies will help to bridge the gap between rodent and human RGC studies and increase study translatability to guide future therapeutic strategies.</p>","PeriodicalId":23325,"journal":{"name":"Trends in Neurosciences","volume":null,"pages":null},"PeriodicalIF":14.6,"publicationDate":"2024-10-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142508800","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
CAMs in command: aging brain macrophages fine-tune stroke immune responses. CAMs指挥:衰老的脑巨噬细胞可微调中风免疫反应。
IF 14.6 1区 医学
Trends in Neurosciences Pub Date : 2024-10-22 DOI: 10.1016/j.tins.2024.10.002
Rodney M Ritzel, Danye Jiang, Louise D McCullough
{"title":"CAMs in command: aging brain macrophages fine-tune stroke immune responses.","authors":"Rodney M Ritzel, Danye Jiang, Louise D McCullough","doi":"10.1016/j.tins.2024.10.002","DOIUrl":"https://doi.org/10.1016/j.tins.2024.10.002","url":null,"abstract":"<p><p>Central nervous system-associated macrophages (CAMs) are a unique subset of immune cells located at the interface between the blood and the brain parenchyma. In a recent study in mice, Levard and colleagues found that CAMs regulate immune cell trafficking, endothelial activation, and antigen presentation following stroke exclusively in aged animals, underscoring the importance of using translationally relevant models for studying age-related diseases.</p>","PeriodicalId":23325,"journal":{"name":"Trends in Neurosciences","volume":null,"pages":null},"PeriodicalIF":14.6,"publicationDate":"2024-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142508798","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The injured axon: intrinsic mechanisms driving axonal regeneration. 受伤的轴突:驱动轴突再生的内在机制。
IF 14.6 1区 医学
Trends in Neurosciences Pub Date : 2024-10-21 DOI: 10.1016/j.tins.2024.09.009
Diogo Tomé, Ramiro D Almeida
{"title":"The injured axon: intrinsic mechanisms driving axonal regeneration.","authors":"Diogo Tomé, Ramiro D Almeida","doi":"10.1016/j.tins.2024.09.009","DOIUrl":"https://doi.org/10.1016/j.tins.2024.09.009","url":null,"abstract":"<p><p>Injury to the central nervous system (CNS) often results in permanent neurological impairments because axons fail to regenerate and re-establish lost synaptic contacts. By contrast, peripheral neurons can activate a pro-regenerative program and regenerate following a nerve lesion. This relies on an intricate intracellular communication system between the severed axon and the cell body. Locally activated signaling molecules are retrogradely transported to the soma to promote the epigenetic and transcriptional changes required for the injured neuron to regain growth competence. These signaling events rely heavily on intra-axonal translation and mitochondrial trafficking into the severed axon. Here, we discuss the interplay between these mechanisms and the main intrinsic barriers to axonal regeneration. We also examine the potential of manipulating these processes for driving CNS repair.</p>","PeriodicalId":23325,"journal":{"name":"Trends in Neurosciences","volume":null,"pages":null},"PeriodicalIF":14.6,"publicationDate":"2024-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142508801","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Neural circuits for goal-directed navigation across species. 不同物种目标导航的神经回路
IF 14.6 1区 医学
Trends in Neurosciences Pub Date : 2024-10-10 DOI: 10.1016/j.tins.2024.09.005
Jayeeta Basu, Katherine Nagel
{"title":"Neural circuits for goal-directed navigation across species.","authors":"Jayeeta Basu, Katherine Nagel","doi":"10.1016/j.tins.2024.09.005","DOIUrl":"https://doi.org/10.1016/j.tins.2024.09.005","url":null,"abstract":"<p><p>Across species, navigation is crucial for finding both resources and shelter. In vertebrates, the hippocampus supports memory-guided goal-directed navigation, whereas in arthropods the central complex supports similar functions. A growing literature is revealing similarities and differences in the organization and function of these brain regions. We review current knowledge about how each structure supports goal-directed navigation by building internal representations of the position or orientation of an animal in space, and of the location or direction of potential goals. We describe input pathways to each structure - medial and lateral entorhinal cortex in vertebrates, and columnar and tangential neurons in insects - that primarily encode spatial and non-spatial information, respectively. Finally, we highlight similarities and differences in spatial encoding across clades and suggest experimental approaches to compare coding principles and behavioral capabilities across species. Such a comparative approach can provide new insights into the neural basis of spatial navigation and neural computation.</p>","PeriodicalId":23325,"journal":{"name":"Trends in Neurosciences","volume":null,"pages":null},"PeriodicalIF":14.6,"publicationDate":"2024-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142406938","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Emerging roles of antimicrobial peptides in innate immunity, neuronal function, and neurodegeneration. 抗菌肽在先天性免疫、神经元功能和神经退化中的新作用。
IF 14.6 1区 医学
Trends in Neurosciences Pub Date : 2024-10-09 DOI: 10.1016/j.tins.2024.09.001
Soojin Lee, Neal Silverman, Fen-Biao Gao
{"title":"Emerging roles of antimicrobial peptides in innate immunity, neuronal function, and neurodegeneration.","authors":"Soojin Lee, Neal Silverman, Fen-Biao Gao","doi":"10.1016/j.tins.2024.09.001","DOIUrl":"10.1016/j.tins.2024.09.001","url":null,"abstract":"<p><p>Antimicrobial peptides (AMPs), a collection of small proteins with important roles in classical innate immunity, have been extensively studied in multiple organisms, particularly in Drosophila melanogaster. Advances in CRISPR/Cas9 genome editing have allowed individual AMP functions to be dissected, revealing specific and selective roles in host defense. Recent findings have also revealed many unexpected contributions of endogenous AMPs to neuronal functions and neurodegenerative diseases, and have shed light on the intersections between innate immunity and neurobiology. We explore the intricate relationships between AMPs and sleep regulation, memory formation, as well as traumatic brain injury and several neurodegenerative diseases such as Alzheimer's disease (AD), frontotemporal dementia (FTD), and Parkinson's disease (PD). Understanding the diverse functions of AMPs opens new avenues for neuroinflammation and neurodegenerative disease research and potential therapeutic development.</p>","PeriodicalId":23325,"journal":{"name":"Trends in Neurosciences","volume":null,"pages":null},"PeriodicalIF":14.6,"publicationDate":"2024-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142401438","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Defining and characterizing neuronal senescence, 'neurescence', as GX arrested cells. 将神经元衰老("神经衰老")定义为 GX 停止细胞,并确定其特征。
IF 14.6 1区 医学
Trends in Neurosciences Pub Date : 2024-10-09 DOI: 10.1016/j.tins.2024.09.006
Hannah R Hudson, Markus Riessland, Miranda E Orr
{"title":"Defining and characterizing neuronal senescence, 'neurescence', as G<sub>X</sub> arrested cells.","authors":"Hannah R Hudson, Markus Riessland, Miranda E Orr","doi":"10.1016/j.tins.2024.09.006","DOIUrl":"https://doi.org/10.1016/j.tins.2024.09.006","url":null,"abstract":"<p><p>Cellular senescence is a cell state characterized by resistance to apoptosis and stable cell cycle arrest. Senescence was first observed in mitotic cells in vitro. Recent evidence from in vivo studies and human tissue indicates that postmitotic cells, including neurons, may also become senescent. The quiescent cell state of neurons and inconsistent descriptions of neuronal senescence across studies, however, have caused confusion in this burgeoning field. We summarize evidence demonstrating that exit from G<sub>0</sub> quiescence may protect neurons against apoptosis and predispose them toward senescence. Additionally, we propose the term 'neurescent' for senescent neurons and introduce the cell state, G<sub>X</sub>, to describe cell cycle arrest achieved by passing through G<sub>0</sub> quiescence. Criteria are provided to identify neurescent cells, distinguish them from G<sub>0</sub> quiescent neurons, and compare neurescent phenotypes with classic replicative senescence.</p>","PeriodicalId":23325,"journal":{"name":"Trends in Neurosciences","volume":null,"pages":null},"PeriodicalIF":14.6,"publicationDate":"2024-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142401437","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Examining resilience to Alzheimer's disease through the lens of monoaminergic neuromodulator systems. 从单胺类神经调节系统的角度研究阿尔茨海默氏症的恢复能力。
IF 14.6 1区 医学
Trends in Neurosciences Pub Date : 2024-10-04 DOI: 10.1016/j.tins.2024.09.004
Jennifer L Crawford, Anne S Berry
{"title":"Examining resilience to Alzheimer's disease through the lens of monoaminergic neuromodulator systems.","authors":"Jennifer L Crawford, Anne S Berry","doi":"10.1016/j.tins.2024.09.004","DOIUrl":"https://doi.org/10.1016/j.tins.2024.09.004","url":null,"abstract":"<p><p>The monoaminergic nuclei are thought to be some of the earliest sites of Alzheimer's disease (AD) pathology in the brain, with tau-containing pretangles appearing in these nuclei decades before the onset of clinical impairments. It has increasingly been recognized that monoamine systems represent a critical target of investigation towards understanding the progression of AD and designing early detection and treatment approaches. This review synthesizes evidence across animal studies, human neuropathology, and state-of-the-art neuroimaging and daily life assessment methods in humans, which demonstrate robust relationships between monoamine systems and AD pathophysiology and behavior. Further, the review highlights the promise of multimethod, multisystem approaches to studying monoaminergic mechanisms of resilience to AD pathology.</p>","PeriodicalId":23325,"journal":{"name":"Trends in Neurosciences","volume":null,"pages":null},"PeriodicalIF":14.6,"publicationDate":"2024-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142378256","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
相关产品
×
本文献相关产品
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信