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Spatiotemporal calcium dynamics orchestrate oligodendrocyte development and myelination.
IF 14.6 1区 医学
Trends in Neurosciences Pub Date : 2025-03-27 DOI: 10.1016/j.tins.2025.02.010
Jiaxing Li, Frederic Fiore, Kelly R Monk, Amit Agarwal
{"title":"Spatiotemporal calcium dynamics orchestrate oligodendrocyte development and myelination.","authors":"Jiaxing Li, Frederic Fiore, Kelly R Monk, Amit Agarwal","doi":"10.1016/j.tins.2025.02.010","DOIUrl":"https://doi.org/10.1016/j.tins.2025.02.010","url":null,"abstract":"<p><p>Oligodendrocyte lineage cells (OLCs), comprising oligodendrocyte precursor cells (OPCs) and oligodendrocytes, are pivotal in sculpting central nervous system (CNS) architecture and function. OPCs mature into oligodendrocytes, which enwrap axons with myelin sheaths that are critical for enhancing neural transmission. Notably, OLCs actively respond to neuronal activity, modulating neural circuit functions. Understanding neuron-OLC interactions is key to unraveling how OLCs contribute to CNS health and pathology. This review highlights insights from zebrafish and mouse models, revealing how synaptic and extrasynaptic pathways converge to shape spatiotemporal calcium (Ca<sup>2+</sup>) dynamics within OLCs. We explore how Ca<sup>2+</sup> signal integration across spatial and temporal scales acts as a master regulator of OLC fate determination and myelin plasticity.</p>","PeriodicalId":23325,"journal":{"name":"Trends in Neurosciences","volume":" ","pages":""},"PeriodicalIF":14.6,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143744069","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Epigenetic and metabolic regulation of developmental timing in neocortex evolution.
IF 14.6 1区 医学
Trends in Neurosciences Pub Date : 2025-03-27 DOI: 10.1016/j.tins.2025.03.001
Matilde Aquilino, Nora Ditzer, Takashi Namba, Mareike Albert
{"title":"Epigenetic and metabolic regulation of developmental timing in neocortex evolution.","authors":"Matilde Aquilino, Nora Ditzer, Takashi Namba, Mareike Albert","doi":"10.1016/j.tins.2025.03.001","DOIUrl":"https://doi.org/10.1016/j.tins.2025.03.001","url":null,"abstract":"<p><p>The human brain is characterized by impressive cognitive abilities. The neocortex is the seat of higher cognition, and neocortex expansion is a hallmark of human evolution. While developmental programs are similar in different species, the timing of developmental transitions and the capacity of neural progenitor cells (NPCs) to proliferate differ, contributing to the increased production of neurons during human cortical development. Here, we review the epigenetic regulation of developmental transitions during corticogenesis, focusing mostly on humans while building on knowledge from studies in mice. We discuss metabolic-epigenetic interplay as a potential mechanism to integrate extracellular signals into neural chromatin. Moreover, we synthesize current understanding of how epigenetic and metabolic deregulation can cause neurodevelopmental disorders. Finally, we outline how developmental timing can be investigated using brain organoid models.</p>","PeriodicalId":23325,"journal":{"name":"Trends in Neurosciences","volume":" ","pages":""},"PeriodicalIF":14.6,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143744067","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Understanding disrupted motivation in Parkinson's disease through a value-based decision-making lens.
IF 14.6 1区 医学
Trends in Neurosciences Pub Date : 2025-03-25 DOI: 10.1016/j.tins.2025.02.008
Campbell Le Heron, Lee-Anne Morris, Sanjay Manohar
{"title":"Understanding disrupted motivation in Parkinson's disease through a value-based decision-making lens.","authors":"Campbell Le Heron, Lee-Anne Morris, Sanjay Manohar","doi":"10.1016/j.tins.2025.02.008","DOIUrl":"https://doi.org/10.1016/j.tins.2025.02.008","url":null,"abstract":"<p><p>Neurobehavioural disturbances such as loss of motivation have profound effects on the lives of many people living with Parkinson's disease (PD), as well as other brain disorders. The field of decision-making neuroscience, underpinned by a plethora of work across species, provides an important framework within which to investigate apathy in clinical populations. Here we review how changes in a number of different processes underlying value-based decision making may lead to the common phenotype of apathy in PD. The application of computational models to probe both behaviour and neurophysiology show promise in elucidating these cognitive processes crucial for motivated behaviour. However, observations from the clinical management of PD demand an expanded view of this relationship, which we aim to delineate. Ultimately, effective treatment of apathy may depend on identifying the pattern in which decision making and related mechanisms have been disrupted in individuals living with PD.</p>","PeriodicalId":23325,"journal":{"name":"Trends in Neurosciences","volume":" ","pages":""},"PeriodicalIF":14.6,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143721633","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The long and the short of TDP-43.
IF 14.6 1区 医学
Trends in Neurosciences Pub Date : 2025-03-24 DOI: 10.1016/j.tins.2025.03.003
Marc Shenouda, Paul M McKeever, Janice Robertson
{"title":"The long and the short of TDP-43.","authors":"Marc Shenouda, Paul M McKeever, Janice Robertson","doi":"10.1016/j.tins.2025.03.003","DOIUrl":"https://doi.org/10.1016/j.tins.2025.03.003","url":null,"abstract":"<p><p>In a recent study, Dykstra and colleagues show that shortened TAR DNA Binding Protein 43 (sTDP-43) isoforms are generated as by-products of TDP-43 autoregulation. sTDP-43 levels are regulated through nonsense-mediated decay and proteasomal and autophagic degradation, and elicit toxicity through dominant negative effects on TDP-43 splicing activity. These results identify mechanisms contributing to sTDP-43 accumulation and toxicity in disease.</p>","PeriodicalId":23325,"journal":{"name":"Trends in Neurosciences","volume":" ","pages":""},"PeriodicalIF":14.6,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143711462","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Somatic mosaicism and interneuron involvement in mTORopathies.
IF 14.6 1区 医学
Trends in Neurosciences Pub Date : 2025-03-21 DOI: 10.1016/j.tins.2025.02.009
Lilian G Jerow, Darcy A Krueger, Christina Gross, Steve C Danzer
{"title":"Somatic mosaicism and interneuron involvement in mTORopathies.","authors":"Lilian G Jerow, Darcy A Krueger, Christina Gross, Steve C Danzer","doi":"10.1016/j.tins.2025.02.009","DOIUrl":"10.1016/j.tins.2025.02.009","url":null,"abstract":"<p><p>Somatic mutations in genes regulating mechanistic target of rapamycin (mTOR) pathway signaling can cause epilepsy, autism, and cognitive dysfunction. Research has predominantly focused on mTOR regulation of excitatory neurons in these conditions; however, dysregulated mTOR signaling among interneurons may also be critical. In this review, we discuss clinical evidence for interneuron involvement, and potential mechanisms, known and hypothetical, by which interneurons might come to directly harbor pathogenic mutations. To understand how mTOR hyperactive interneurons might drive dysfunction, we review studies in which mTOR signaling has been selectively disrupted among interneurons and interneuron progenitors in mouse model systems. Complex cellular mosaicism and dual roles for mTOR (hyper)activation in mediating disease pathogenesis and homeostatic responses raise challenging questions for effective treatment of these disorders.</p>","PeriodicalId":23325,"journal":{"name":"Trends in Neurosciences","volume":" ","pages":""},"PeriodicalIF":14.6,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143693475","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Awake replay: off the clock but on the job.
IF 14.6 1区 医学
Trends in Neurosciences Pub Date : 2025-03-21 DOI: 10.1016/j.tins.2025.02.006
Matthijs A A van der Meer, Daniel Bendor
{"title":"Awake replay: off the clock but on the job.","authors":"Matthijs A A van der Meer, Daniel Bendor","doi":"10.1016/j.tins.2025.02.006","DOIUrl":"https://doi.org/10.1016/j.tins.2025.02.006","url":null,"abstract":"<p><p>Hippocampal replay is widely thought to support two key cognitive functions: online decision-making and offline memory consolidation. In this review, we take a closer look at the hypothesized link between awake replay and online decision-making in rodents, and find only marginal evidence in support of this role. By contrast, the consolidation view is bolstered by new computational ideas and recent data, suggesting that (i) replay performs offline fictive learning for later goal-oriented behavior; and (ii) replay tags memories prior to sleep, prioritizing them for consolidation. Based on these recent advances, we favor an updated and refined role for awake replay - that is, supporting prioritized offline learning and tagging outside the hippocampus - rather than a direct, online role in guiding behavior.</p>","PeriodicalId":23325,"journal":{"name":"Trends in Neurosciences","volume":" ","pages":""},"PeriodicalIF":14.6,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143693467","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A role for respiration in coordinating sleep oscillations and memory consolidation.
IF 14.6 1区 医学
Trends in Neurosciences Pub Date : 2025-03-21 DOI: 10.1016/j.tins.2025.02.005
Fabian Schwimmbeck, Esteban Bullón Tarrasó, Thomas Schreiner
{"title":"A role for respiration in coordinating sleep oscillations and memory consolidation.","authors":"Fabian Schwimmbeck, Esteban Bullón Tarrasó, Thomas Schreiner","doi":"10.1016/j.tins.2025.02.005","DOIUrl":"https://doi.org/10.1016/j.tins.2025.02.005","url":null,"abstract":"<p><p>Memory consolidation is thought to rely on the interplay of sleep-related brain oscillations. Drawing on recent findings that highlight the influence of respiration on these rhythms, we outline a framework positioning respiration as pacemaker for sleep's memory function. By orchestrating the cardinal non-rapid eye movement (NREM) oscillations, namely slow oscillations, spindles, and sharp wave-ripples, respiration may coordinate the hippocampo-cortical crosstalk essential for memory consolidation.</p>","PeriodicalId":23325,"journal":{"name":"Trends in Neurosciences","volume":" ","pages":""},"PeriodicalIF":14.6,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143693439","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
MicroRNA regulation of enteric nervous system development and disease.
IF 14.6 1区 医学
Trends in Neurosciences Pub Date : 2025-03-14 DOI: 10.1016/j.tins.2025.02.004
Amy Marie Holland, Reindert Jehoul, Jorunn Vranken, Stefanie Gabriele Wohl, Werend Boesmans
{"title":"MicroRNA regulation of enteric nervous system development and disease.","authors":"Amy Marie Holland, Reindert Jehoul, Jorunn Vranken, Stefanie Gabriele Wohl, Werend Boesmans","doi":"10.1016/j.tins.2025.02.004","DOIUrl":"https://doi.org/10.1016/j.tins.2025.02.004","url":null,"abstract":"<p><p>The enteric nervous system (ENS), an elaborate network of neurons and glia woven through the gastrointestinal tract, is integral for digestive physiology and broader human health. Commensurate with its importance, ENS dysfunction is linked to a range of debilitating gastrointestinal disorders. MicroRNAs (miRNAs), with their pleiotropic roles in post-transcriptional gene regulation, serve as key developmental effectors within the ENS. Herein, we review the regulatory dynamics of miRNAs in ENS ontogeny, showcasing specific miRNAs implicated in both congenital and acquired enteric neuropathies, such as Hirschsprung's disease (HSCR), achalasia, intestinal neuronal dysplasia (IND), chronic intestinal pseudo-obstruction (CIPO), and slow transit constipation (STC). By delineating miRNA-mediated mechanisms in these diseases, we underscore their importance for ENS homeostasis and highlight their potential as therapeutic targets.</p>","PeriodicalId":23325,"journal":{"name":"Trends in Neurosciences","volume":" ","pages":""},"PeriodicalIF":14.6,"publicationDate":"2025-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143634762","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The curious interpretation of novel object recognition tests. 新物体识别测试的奇特解释
IF 14.6 1区 医学
Trends in Neurosciences Pub Date : 2025-03-13 DOI: 10.1016/j.tins.2025.02.003
Adam P Swiercz, Mumeko C Tsuda, Heather A Cameron
{"title":"The curious interpretation of novel object recognition tests.","authors":"Adam P Swiercz, Mumeko C Tsuda, Heather A Cameron","doi":"10.1016/j.tins.2025.02.003","DOIUrl":"https://doi.org/10.1016/j.tins.2025.02.003","url":null,"abstract":"<p><p>Novel object recognition tasks are commonly used to assess memory in rodents. These tests rely on an innate preference for exploring objects that are new or have been moved or changed. However, this preference, while normally seen in control conditions, is not immutable. Stressful experiences as well as lesions and genetic mutations can lead mice and rats to show clear preferences for exploring familiar objects and familiar locations. This opinion article discusses the evidence for changes in novelty preference, implications of this lability for assessing memory, and the significance of shifts in novelty preference as a readout of changes in curiosity with implications in approach-avoidance behavior and explore-exploit decision-making. Finally, we provide some recommendations for reporting and interpreting novelty preference task findings moving forward.</p>","PeriodicalId":23325,"journal":{"name":"Trends in Neurosciences","volume":" ","pages":""},"PeriodicalIF":14.6,"publicationDate":"2025-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143630833","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Attenuating the neuronal response to chronic stress through transcription factor aggregation.
IF 14.6 1区 医学
Trends in Neurosciences Pub Date : 2025-03-10 DOI: 10.1016/j.tins.2025.02.007
Mathilde Solyga, Florence Besse
{"title":"Attenuating the neuronal response to chronic stress through transcription factor aggregation.","authors":"Mathilde Solyga, Florence Besse","doi":"10.1016/j.tins.2025.02.007","DOIUrl":"https://doi.org/10.1016/j.tins.2025.02.007","url":null,"abstract":"<p><p>How do neurons cope with chronic stress? In a recent study using blind Drosophila models, Shekhar and colleagues uncovered that chronic sensory deprivation induces brain-wide accumulation of aggregates sequestering transcription factors of the Integrated Stress Response (ISR). However, this protective mechanism prevents cells from triggering adapted transcriptional responses upon exogenous stress.</p>","PeriodicalId":23325,"journal":{"name":"Trends in Neurosciences","volume":" ","pages":""},"PeriodicalIF":14.6,"publicationDate":"2025-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143605995","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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