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Trends in Neurosciences最新文献

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Organization of neuropeptide signaling: cross-species insights from small model organisms. 神经肽信号的组织：来自小型模式生物的跨物种见解。
IF 15.7 1区 医学
Trends in Neurosciences Pub Date : 2026-10-27 DOI: 10.1016/j.tins.2026.09.012
Meet Zandawala, Alessandro Filosa, Isabel Beets
{"title":"Organization of neuropeptide signaling: cross-species insights from small model organisms.","authors":"Meet Zandawala, Alessandro Filosa, Isabel Beets","doi":"10.1016/j.tins.2026.09.012","DOIUrl":"https://doi.org/10.1016/j.tins.2026.09.012","url":null,"abstract":"<p><p>Neuropeptides are ancient signaling molecules that modulate neural circuit function and behavior across the animal kingdom. Model organisms such as Caenorhabditis elegans, Drosophila melanogaster, and zebrafish serve as powerful in vivo models for deciphering the organization of neuropeptidergic signaling, owing to their smaller nervous systems, genetic tractability, and the growing availability of neural connectomes. In this article, we review how these organisms have advanced current understanding of neuropeptidergic transmission across three interconnected themes: (i) the roles of peptides in sensory-motor transformations, (ii) the conservation and divergence of peptidergic expression and network architecture across species, and (iii) the diversity of neurotransmission strategies employed by single neurons. Finally, we highlight recent technological innovations as well as open questions that could shape this field in the coming years.</p>","PeriodicalId":23325,"journal":{"name":"Trends in Neurosciences","volume":" ","pages":""},"PeriodicalIF":15.7,"publicationDate":"2026-10-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149288821","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Tumor innervation in non-central nervous system tumors: origins, mechanisms, and phenotypic plasticity. 非中枢神经系统肿瘤的肿瘤神经支配：起源、机制和表型可塑性。
IF 15.7 1区 医学
Trends in Neurosciences Pub Date : 2026-10-20 DOI: 10.1016/j.tins.2026.08.008
Yonghui Zhang, Zhixin Ye, Ying Wang, Siying Tang, Gang Chen
{"title":"Tumor innervation in non-central nervous system tumors: origins, mechanisms, and phenotypic plasticity.","authors":"Yonghui Zhang, Zhixin Ye, Ying Wang, Siying Tang, Gang Chen","doi":"10.1016/j.tins.2026.08.008","DOIUrl":"https://doi.org/10.1016/j.tins.2026.08.008","url":null,"abstract":"<p><p>The peripheral nervous system has emerged as an important regulator of solid tumor biology. We synthesize recent advances in cancer neuroscience, focusing on three interconnected themes: the cellular origins of tumor-associated nerves, the molecular mechanisms that govern neural recruitment and remodeling, and the resulting phenotypic plasticity within the tumor microenvironment. Tumor innervation arises through axon extension from pre-existing nerves, recruitment of neural precursors, and neuron-like transdifferentiation of non-neuronal cells. These processes are driven by neurotrophic factors, axon guidance cues, extracellular vesicles, and stress-associated pathways. The functional consequences of innervation are context-dependent, with sympathetic, parasympathetic, and sensory inputs exerting distinct effects across tumor types and stages. We conclude by outlining key challenges and future directions for therapeutic translation.</p>","PeriodicalId":23325,"journal":{"name":"Trends in Neurosciences","volume":" ","pages":""},"PeriodicalIF":15.7,"publicationDate":"2026-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149228733","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
An insular-orbitofrontal pathway supporting awareness of respiratory effort. 支持呼吸努力意识的岛-眶额通路。
IF 15.7 1区 医学
Trends in Neurosciences Pub Date : 2026-10-20 DOI: 10.1016/j.tins.2026.09.011
Valentina Jelinčić, Andreas von Leupoldt
{"title":"An insular-orbitofrontal pathway supporting awareness of respiratory effort.","authors":"Valentina Jelinčić, Andreas von Leupoldt","doi":"10.1016/j.tins.2026.09.011","DOIUrl":"https://doi.org/10.1016/j.tins.2026.09.011","url":null,"abstract":"<p><p>In a recent study using human intracranial EEG recordings during inspiratory loading, Assi and colleagues identified parallel pathways for respiratory compensation and awareness. The anterior insula signals a neuromechanical mismatch to the orbitofrontal cortex for conscious appraisal, while high-frequency insular-frontal coupling enables ventilatory adjustments. The findings are highly relevant for disorders of altered respiratory perception.</p>","PeriodicalId":23325,"journal":{"name":"Trends in Neurosciences","volume":" ","pages":""},"PeriodicalIF":15.7,"publicationDate":"2026-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149228763","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Apolipoprotein E4 and immune dysfunction in Alzheimer's disease: mechanisms and therapeutic implications. 载脂蛋白E4与阿尔茨海默病的免疫功能障碍：机制和治疗意义。
IF 15.7 1区 医学
Trends in Neurosciences Pub Date : 2026-10-19 DOI: 10.1016/j.tins.2026.09.009
Hao Shi, Yang Zhao, Wei Zhu, Yan-Jiang Wang, Xian-Le Bu
{"title":"Apolipoprotein E4 and immune dysfunction in Alzheimer's disease: mechanisms and therapeutic implications.","authors":"Hao Shi, Yang Zhao, Wei Zhu, Yan-Jiang Wang, Xian-Le Bu","doi":"10.1016/j.tins.2026.09.009","DOIUrl":"https://doi.org/10.1016/j.tins.2026.09.009","url":null,"abstract":"<p><p>Emerging evidence suggests that apolipoprotein E4 (APOE4) functions as an organizer of brain-periphery immune crosstalk, coupling maladaptive microglial states with peripheral immune remodeling to establish a self-reinforcing neuroimmune loop that may accelerate the progression of Alzheimer's disease. In the central nervous system, APOE4 pushes microglia away from homeostatic surveillance toward metabolically stressed, inflammatory, and synaptotoxic phenotypes, thereby weakening pathological protein clearance and promoting neurodegeneration. In the periphery, APOE4 primes innate and adaptive immune cells toward a pro-inflammatory state, creating a reservoir that can communicate with the diseased brain and infiltrate it. In addition, APOE4 erodes the separation between central and peripheral immune compartments, enabling bidirectional immune crosstalk that amplifies neuroinflammation and neurodegeneration. In this review, we synthesize evidence for APOE4-driven central and peripheral immune dysregulation; discuss therapeutic opportunities for targeting the APOE4 immune axis; and highlight the need for human-derived, longitudinal, cross-tissue studies to identify causal, stage-specific, and targetable immune nodes for precision intervention.</p>","PeriodicalId":23325,"journal":{"name":"Trends in Neurosciences","volume":" ","pages":""},"PeriodicalIF":15.7,"publicationDate":"2026-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149220744","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Resilience and vulnerability in the midbrain dopamine system during aging. 衰老过程中脑多巴胺系统的弹性和脆弱性。
IF 15.7 1区 医学
Trends in Neurosciences Pub Date : 2026-10-14 DOI: 10.1016/j.tins.2026.09.008
Gary McMurtrie, Samuel J Mabry, Jill R Glausier, Emily M Rocha, Zachary Freyberg
{"title":"Resilience and vulnerability in the midbrain dopamine system during aging.","authors":"Gary McMurtrie, Samuel J Mabry, Jill R Glausier, Emily M Rocha, Zachary Freyberg","doi":"10.1016/j.tins.2026.09.008","DOIUrl":"https://doi.org/10.1016/j.tins.2026.09.008","url":null,"abstract":"<p><p>The midbrain dopamine system is integral to movement, reward, and motivation, and its dysfunction underlies a range of brain disorders. Age is a primary risk factor for many of these disorders, yet systematic analysis of how the dopamine system changes during healthy aging remains relatively understudied. In this review, we first examine the impact of healthy aging on the dopamine system across sexes and species, including flies, mice, rats, and humans. We next consider the neuroadaptive mechanisms that sustain dopamine neuron function with age. Finally, we contrast the molecular mechanisms of age-related neurodegenerative diseases with those of healthy aging, exploring the possibility that loss of neuroadaptive reserve drives dopamine neurodegeneration. Elucidating these neuroadaptive mechanisms could offer a path toward preserving dopamine neuron function across the lifespan and potentially preventing age-related neurodegeneration.</p>","PeriodicalId":23325,"journal":{"name":"Trends in Neurosciences","volume":" ","pages":""},"PeriodicalIF":15.7,"publicationDate":"2026-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149184644","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A brain circuit linking sleep loss to pain. 大脑回路将睡眠不足与疼痛联系起来。
IF 15.7 1区 医学
Trends in Neurosciences Pub Date : 2026-10-14 DOI: 10.1016/j.tins.2026.09.010
Miao Li, Guang Yang
{"title":"A brain circuit linking sleep loss to pain.","authors":"Miao Li, Guang Yang","doi":"10.1016/j.tins.2026.09.010","DOIUrl":"https://doi.org/10.1016/j.tins.2026.09.010","url":null,"abstract":"<p><p>Sleep loss heightens pain sensitivity, but the brain circuits involved remain unclear. In a recent study, Huang, Wang, Jiao, and colleagues identified a pathway connecting the retrosplenial cortex, anterior cingulate cortex, and zona incerta that contributes to heightened sensitivity to mechanical stimulation and heat after sleep deprivation in male mice.</p>","PeriodicalId":23325,"journal":{"name":"Trends in Neurosciences","volume":" ","pages":""},"PeriodicalIF":15.7,"publicationDate":"2026-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149184618","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The mitochondrial epigenome and noncoding genome in aging and brain diseases. 线粒体表观基因组和非编码基因组在衰老和脑部疾病中的作用。
IF 15.7 1区 医学
Trends in Neurosciences Pub Date : 2026-10-10 DOI: 10.1016/j.tins.2026.09.007
Abd-El-Monsif A Shawky, Hui-Ting Huang, Dhruv Parikh, Kahlilia C Morris-Blanco
{"title":"The mitochondrial epigenome and noncoding genome in aging and brain diseases.","authors":"Abd-El-Monsif A Shawky, Hui-Ting Huang, Dhruv Parikh, Kahlilia C Morris-Blanco","doi":"10.1016/j.tins.2026.09.007","DOIUrl":"10.1016/j.tins.2026.09.007","url":null,"abstract":"<p><p>The mitochondrial genome is a dynamic regulatory platform that extends far beyond its protein-coding capacity. Mitochondrial DNA (mtDNA) harbors epigenetic modifications and produces diverse noncoding RNAs that influence mitochondrial function and cellular homeostasis. Evidence from animal models and human studies indicates that mtDNA methylation, mitochondrial-encoded noncoding RNAs, and cytosolic release of mitochondrial nucleic acids regulate transcription, metabolism, and stress signaling. Furthermore, these mechanisms are altered in aging, neurodegenerative disease, and acute brain injury. In this review, we synthesize emerging insights into how the mitochondrial epigenome and noncoding genome shape mitochondrial function and serve as regulatory interfaces linking cellular stress and neuronal vulnerability in brain aging and disease.</p>","PeriodicalId":23325,"journal":{"name":"Trends in Neurosciences","volume":" ","pages":""},"PeriodicalIF":15.7,"publicationDate":"2026-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13660430/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149168003","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Interpersonal neural synchrony: one label, many phenomena. 人际神经同步：一个标签，多种现象。
IF 15.7 1区 医学
Trends in Neurosciences Pub Date : 2026-10-07 DOI: 10.1016/j.tins.2026.09.006
Giacomo Novembre, Atesh Koul, Félix Bigand
{"title":"Interpersonal neural synchrony: one label, many phenomena.","authors":"Giacomo Novembre, Atesh Koul, Félix Bigand","doi":"10.1016/j.tins.2026.09.006","DOIUrl":"https://doi.org/10.1016/j.tins.2026.09.006","url":null,"abstract":"<p><p>Brains synchronize interpersonally during social interaction, yet the term 'synchrony' is often used to describe phenomena with different origins and functional implications. In this article, we briefly synthesize and organize these phenomena according to their signal and coupling properties, highlighting the value of disambiguation for reproducibility, theoretical clarity, and translational impact.</p>","PeriodicalId":23325,"journal":{"name":"Trends in Neurosciences","volume":" ","pages":""},"PeriodicalIF":15.7,"publicationDate":"2026-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149128779","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
An epigenetic view of anxiety disorders, one cell type at a time. 焦虑症的表观遗传学观点，一次一种细胞类型。
IF 15.7 1区 医学
Trends in Neurosciences Pub Date : 2026-10-01 Epub Date: 2026-08-12 DOI: 10.1016/j.tins.2026.07.007
Klara Mareckova, Yuliya S Nikolova
{"title":"An epigenetic view of anxiety disorders, one cell type at a time.","authors":"Klara Mareckova, Yuliya S Nikolova","doi":"10.1016/j.tins.2026.07.007","DOIUrl":"10.1016/j.tins.2026.07.007","url":null,"abstract":"<p><p>A recent publication by Ingram et al. revealed the importance of cellular precision in psychiatric epigenetics. Using cellular deconvolution, the authors showed that anxiety is associated with cell type-specific DNA methylation signatures reflecting stress, inflammation, and accelerated aging. These findings have critical implications for neuroscience studies aiming to bridge the gap between the peripheral epigenome and brain function.</p>","PeriodicalId":23325,"journal":{"name":"Trends in Neurosciences","volume":" ","pages":"799-800"},"PeriodicalIF":15.7,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148722257","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Amygdala excitability across development: mechanisms, environmental influences, and behavioral outcomes. 发育过程中的杏仁核兴奋性：机制、环境影响和行为结果。
IF 15.7 1区 医学
Trends in Neurosciences Pub Date : 2026-10-01 Epub Date: 2026-08-29 DOI: 10.1016/j.tins.2026.08.001
Ingrid Ehrlich, Sari E Lauri
{"title":"Amygdala excitability across development: mechanisms, environmental influences, and behavioral outcomes.","authors":"Ingrid Ehrlich, Sari E Lauri","doi":"10.1016/j.tins.2026.08.001","DOIUrl":"10.1016/j.tins.2026.08.001","url":null,"abstract":"<p><p>Recent work in rodent models provides mechanistic insights into how the excitability of principal neurons is dynamically regulated to facilitate the encoding and retrieval of emotionally salient memories in the basolateral amygdala (BLA). In this review, we discuss the physiological mechanisms governing BLA excitability, emphasizing their impact on the recruitment of defined BLA ensembles encoding distinct behavioral states. In addition, we summarize the current understanding of how these mechanisms are established during development and suggest that this may follow distinct developmental phases. Lastly, we outline recent findings on how early-life adversity or genetic risk factors can acutely perturb developmental trajectories and may lead to enduring changes in BLA circuit function, with implications for neurodevelopmental disorders.</p>","PeriodicalId":23325,"journal":{"name":"Trends in Neurosciences","volume":" ","pages":"825-840"},"PeriodicalIF":15.7,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148851346","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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