Reconstructing Alzheimer's disease one cell type at a time using in vitro tricultures.

IF 15.1 1区医学 Q1 NEUROSCIENCES

Trends in Neurosciences Pub Date : 2025-09-01 Epub Date: 2025-07-29 DOI:10.1016/j.tins.2025.07.010

Tatiana A Giovannucci, Charles Arber, Selina Wray

引用次数: 0

Abstract

In a recent study, Lish and colleagues used a fully human-based, induced pluripotent stem cell (iPSC)-derived triculture model of neurons, astrocytes, and microglia to delineate non-cell autonomous contributions to familial Alzheimer's disease (AD). This approach offers a versatile platform to explore early disease mechanisms, dissect cell-cell interactions, and support the development of targeted therapeutic or biomarker strategies.

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利用体外培养一次重建一种细胞类型的阿尔茨海默病。

在最近的一项研究中，Lish和他的同事使用了一个完全基于人类的，诱导多能干细胞（iPSC）衍生的神经元，星形胶质细胞和小胶质细胞的三培养模型来描述家族性阿尔茨海默病（AD）的非细胞自主贡献。这种方法提供了一个多功能的平台来探索早期疾病机制，解剖细胞-细胞相互作用，并支持靶向治疗或生物标志物策略的发展。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Trends in Neurosciences 医学-神经科学

CiteScore

26.50

自引率

1.30%

发文量

123

审稿时长

6-12 weeks

期刊介绍： For over four decades, Trends in Neurosciences (TINS) has been a prominent source of inspiring reviews and commentaries across all disciplines of neuroscience. TINS is a monthly, peer-reviewed journal, and its articles are curated by the Editor and authored by leading researchers in their respective fields. The journal communicates exciting advances in brain research, serves as a voice for the global neuroscience community, and highlights the contribution of neuroscientific research to medicine and society.