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Splenic nociceptive neural connection promotes humoral immunity. 脾脏痛觉神经连接可促进体液免疫。
IF 14.6 1区 医学
Trends in Neurosciences Pub Date : 2024-12-01 Epub Date: 2024-10-02 DOI: 10.1016/j.tins.2024.09.008
Cheng Qian, Jiaming Wang, Xuetao Cao
{"title":"Splenic nociceptive neural connection promotes humoral immunity.","authors":"Cheng Qian, Jiaming Wang, Xuetao Cao","doi":"10.1016/j.tins.2024.09.008","DOIUrl":"10.1016/j.tins.2024.09.008","url":null,"abstract":"<p><p>Recent work by Wu and colleagues unveiled a previously enigmatic population of spleen-innervating nociceptors from left T8-T13 dorsal root ganglia (DRGs) in mice. They found a specific DRG-spleen sensorineural connection that promotes humoral immunity via a CGRP-CALCRL/RAMP1 axis, providing a valuable target for immune regulation in local microenvironments.</p>","PeriodicalId":23325,"journal":{"name":"Trends in Neurosciences","volume":" ","pages":"968-970"},"PeriodicalIF":14.6,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142366656","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Dopaminergic circuits controlling threat and safety learning. 控制威胁和安全学习的多巴胺能回路
IF 14.6 1区 医学
Trends in Neurosciences Pub Date : 2024-12-01 Epub Date: 2024-10-28 DOI: 10.1016/j.tins.2024.10.001
Sevil Duvarci
{"title":"Dopaminergic circuits controlling threat and safety learning.","authors":"Sevil Duvarci","doi":"10.1016/j.tins.2024.10.001","DOIUrl":"10.1016/j.tins.2024.10.001","url":null,"abstract":"<p><p>The ability to learn from experience that certain cues and situations are associated with threats or safety is crucial for survival and adaptive behavior. Understanding the neural substrates of threat and safety learning has high clinical significance because deficits in these forms of learning characterize anxiety disorders. Traditionally, dopamine neurons were thought to uniformly support reward learning by signaling reward prediction errors. However, the dopamine system is functionally more diverse than was initially appreciated and is also critical for processing threat and safety. In this review, I highlight recent studies demonstrating that dopamine neurons generate prediction errors for threat and safety, and describe how dopamine projections to the amygdala, medial prefrontal cortex (mPFC), and striatum regulate associative threat and safety learning.</p>","PeriodicalId":23325,"journal":{"name":"Trends in Neurosciences","volume":" ","pages":"1014-1027"},"PeriodicalIF":14.6,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142547690","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
An expanding repertoire of circuit mechanisms for visual prediction errors. 视觉预测错误的电路机制不断扩大。
IF 14.6 1区 医学
Trends in Neurosciences Pub Date : 2024-12-01 Epub Date: 2024-11-08 DOI: 10.1016/j.tins.2024.10.007
Jordan M Ross, Jordan P Hamm
{"title":"An expanding repertoire of circuit mechanisms for visual prediction errors.","authors":"Jordan M Ross, Jordan P Hamm","doi":"10.1016/j.tins.2024.10.007","DOIUrl":"10.1016/j.tins.2024.10.007","url":null,"abstract":"<p><p>Cortical responses to stimuli vary dependingon context and expectation. Adding insight into this process, Furutachi et al. recently demonstrated that higher-order thalamic input to visual cortex cooperates with interneurons to augment responses to unexpected stimuli, consistent with a body of literature implicating top-down modulation and local inhibition in predictive processing.</p>","PeriodicalId":23325,"journal":{"name":"Trends in Neurosciences","volume":" ","pages":"963-964"},"PeriodicalIF":14.6,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11631631/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142629170","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Retinal ganglion cell circuits and glial interactions in humans and mice. 人类和小鼠的视网膜神经节细胞回路和神经胶质相互作用。
IF 14.6 1区 医学
Trends in Neurosciences Pub Date : 2024-12-01 Epub Date: 2024-10-24 DOI: 10.1016/j.tins.2024.09.010
Kang-Chieh Huang, Mohamed Tawfik, Melanie A Samuel
{"title":"Retinal ganglion cell circuits and glial interactions in humans and mice.","authors":"Kang-Chieh Huang, Mohamed Tawfik, Melanie A Samuel","doi":"10.1016/j.tins.2024.09.010","DOIUrl":"10.1016/j.tins.2024.09.010","url":null,"abstract":"<p><p>Retinal ganglion cells (RGCs) are the brain's gateway for vision, and their degeneration underlies several blinding diseases. RGCs interact with other neuronal cell types, microglia, and astrocytes in the retina and in the brain. Much knowledge has been gained about RGCs and glia from mice and other model organisms, often with the assumption that certain aspects of their biology may be conserved in humans. However, RGCs vary considerably between species, which could affect how they interact with their neuronal and glial partners. This review details which RGC and glial features are conserved between mice, humans, and primates, and which differ. We also discuss experimental approaches for studying human and primate RGCs. These strategies will help to bridge the gap between rodent and human RGC studies and increase study translatability to guide future therapeutic strategies.</p>","PeriodicalId":23325,"journal":{"name":"Trends in Neurosciences","volume":" ","pages":"994-1013"},"PeriodicalIF":14.6,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11631666/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142508800","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
CAMs in command: aging brain macrophages fine-tune stroke immune responses. CAMs指挥：衰老的脑巨噬细胞可微调中风免疫反应。
IF 14.6 1区 医学
Trends in Neurosciences Pub Date : 2024-12-01 Epub Date: 2024-10-22 DOI: 10.1016/j.tins.2024.10.002
Rodney M Ritzel, Danye Jiang, Louise D McCullough
{"title":"CAMs in command: aging brain macrophages fine-tune stroke immune responses.","authors":"Rodney M Ritzel, Danye Jiang, Louise D McCullough","doi":"10.1016/j.tins.2024.10.002","DOIUrl":"10.1016/j.tins.2024.10.002","url":null,"abstract":"<p><p>Central nervous system-associated macrophages (CAMs) are a unique subset of immune cells located at the interface between the blood and the brain parenchyma. In a recent study in mice, Levard and colleagues found that CAMs regulate immune cell trafficking, endothelial activation, and antigen presentation following stroke exclusively in aged animals, underscoring the importance of using translationally relevant models for studying age-related diseases.</p>","PeriodicalId":23325,"journal":{"name":"Trends in Neurosciences","volume":" ","pages":"965-967"},"PeriodicalIF":14.6,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11631633/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142508798","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cranial motor neuron input specificity refined by activity.
IF 14.6 1区 医学
Trends in Neurosciences Pub Date : 2024-11-27 DOI: 10.1016/j.tins.2024.11.001
Kimberly L McArthur
{"title":"Cranial motor neuron input specificity refined by activity.","authors":"Kimberly L McArthur","doi":"10.1016/j.tins.2024.11.001","DOIUrl":"https://doi.org/10.1016/j.tins.2024.11.001","url":null,"abstract":"<p><p>A recent study by Kaneko and colleagues provides evidence that developing cranial motor neurons in larval zebrafish refine their input specificity over time, using an activity-dependent mechanism that may depend, in part, on adaptive dendrite extension. These findings illuminate the mechanism by which spatially overlapping motor pools are recruited into distinct motor circuits.</p>","PeriodicalId":23325,"journal":{"name":"Trends in Neurosciences","volume":" ","pages":""},"PeriodicalIF":14.6,"publicationDate":"2024-11-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142751826","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Advancing ALS research: public-private partnerships to accelerate drug and biomarker development. 推进 ALS 研究：公私合作加快药物和生物标记物的开发。
IF 14.6 1区 医学
Trends in Neurosciences Pub Date : 2024-11-21 DOI: 10.1016/j.tins.2024.10.008
Alessio Travaglia, Shubhangi Lal, Sri Ramulu Pullagura
{"title":"Advancing ALS research: public-private partnerships to accelerate drug and biomarker development.","authors":"Alessio Travaglia, Shubhangi Lal, Sri Ramulu Pullagura","doi":"10.1016/j.tins.2024.10.008","DOIUrl":"https://doi.org/10.1016/j.tins.2024.10.008","url":null,"abstract":"<p><p>Developing effective treatments for amyotrophic lateral sclerosis (ALS) has been hindered by both the complexity of the disease and decentralized research efforts. By fostering collaboration, standardization, and inclusivity, the Accelerating Medicines Partnership® (AMP®) ALS initiative aims to lay the foundation for future discoveries in ALS biomarkers and treatments.</p>","PeriodicalId":23325,"journal":{"name":"Trends in Neurosciences","volume":" ","pages":""},"PeriodicalIF":14.6,"publicationDate":"2024-11-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142693702","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The intertwined relationship between circadian dysfunction and Parkinson's disease. 昼夜节律失调与帕金森病之间的相互交织关系。
IF 14.6 1区 医学
Trends in Neurosciences Pub Date : 2024-11-21 DOI: 10.1016/j.tins.2024.10.006
Lou C Duret, Emi Nagoshi
{"title":"The intertwined relationship between circadian dysfunction and Parkinson's disease.","authors":"Lou C Duret, Emi Nagoshi","doi":"10.1016/j.tins.2024.10.006","DOIUrl":"https://doi.org/10.1016/j.tins.2024.10.006","url":null,"abstract":"<p><p>Neurodegenerative disorders represent a leading cause of disability among the elderly population, and Parkinson's disease (PD) is the second most prevalent. Emerging evidence suggests a frequent co-occurrence of circadian disruption and PD. However, the nature of this relationship remains unclear: is circadian disruption a cause, consequence, or a parallel feature of the disease that shares the same root cause? This review seeks to address this question by highlighting and discussing clinical evidence and findings from experiments using vertebrate and invertebrate animal models. While research on causality is still in its early stages, the available data suggest reciprocal interactions between PD progression and circadian disruption.</p>","PeriodicalId":23325,"journal":{"name":"Trends in Neurosciences","volume":" ","pages":""},"PeriodicalIF":14.6,"publicationDate":"2024-11-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142693703","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Multiple predictions of others' actions in the human brain. 人脑对他人行为的多重预测
IF 14.6 1区 医学
Trends in Neurosciences Pub Date : 2024-11-19 DOI: 10.1016/j.tins.2024.10.009
Yongling Lin, Marco K Wittmann
{"title":"Multiple predictions of others' actions in the human brain.","authors":"Yongling Lin, Marco K Wittmann","doi":"10.1016/j.tins.2024.10.009","DOIUrl":"https://doi.org/10.1016/j.tins.2024.10.009","url":null,"abstract":"<p><p>The success of our actions often depends on what others are doing. How does the brain discern predictions of others' actions when situations are ambiguous? Recent work by Ma and colleagues suggests that the brain solves this problem by entertaining multiple predictions of others' actions, ranked by their likelihood.</p>","PeriodicalId":23325,"journal":{"name":"Trends in Neurosciences","volume":" ","pages":""},"PeriodicalIF":14.6,"publicationDate":"2024-11-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142682798","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The injured axon: intrinsic mechanisms driving axonal regeneration. 受伤的轴突：驱动轴突再生的内在机制。
IF 14.6 1区 医学
Trends in Neurosciences Pub Date : 2024-11-01 Epub Date: 2024-10-21 DOI: 10.1016/j.tins.2024.09.009
Diogo Tomé, Ramiro D Almeida
{"title":"The injured axon: intrinsic mechanisms driving axonal regeneration.","authors":"Diogo Tomé, Ramiro D Almeida","doi":"10.1016/j.tins.2024.09.009","DOIUrl":"10.1016/j.tins.2024.09.009","url":null,"abstract":"<p><p>Injury to the central nervous system (CNS) often results in permanent neurological impairments because axons fail to regenerate and re-establish lost synaptic contacts. By contrast, peripheral neurons can activate a pro-regenerative program and regenerate following a nerve lesion. This relies on an intricate intracellular communication system between the severed axon and the cell body. Locally activated signaling molecules are retrogradely transported to the soma to promote the epigenetic and transcriptional changes required for the injured neuron to regain growth competence. These signaling events rely heavily on intra-axonal translation and mitochondrial trafficking into the severed axon. Here, we discuss the interplay between these mechanisms and the main intrinsic barriers to axonal regeneration. We also examine the potential of manipulating these processes for driving CNS repair.</p>","PeriodicalId":23325,"journal":{"name":"Trends in Neurosciences","volume":" ","pages":"875-891"},"PeriodicalIF":14.6,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142508801","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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