发布求助
文献互助 智能选刊 最新文献

Trends in Neurosciences最新文献

筛选
英文 中文
Attenuating the neuronal response to chronic stress through transcription factor aggregation.
IF 14.6 1区 医学
Trends in Neurosciences Pub Date : 2025-03-10 DOI: 10.1016/j.tins.2025.02.007
Mathilde Solyga, Florence Besse
{"title":"Attenuating the neuronal response to chronic stress through transcription factor aggregation.","authors":"Mathilde Solyga, Florence Besse","doi":"10.1016/j.tins.2025.02.007","DOIUrl":"https://doi.org/10.1016/j.tins.2025.02.007","url":null,"abstract":"<p><p>How do neurons cope with chronic stress? In a recent study using blind Drosophila models, Shekhar and colleagues uncovered that chronic sensory deprivation induces brain-wide accumulation of aggregates sequestering transcription factors of the Integrated Stress Response (ISR). However, this protective mechanism prevents cells from triggering adapted transcriptional responses upon exogenous stress.</p>","PeriodicalId":23325,"journal":{"name":"Trends in Neurosciences","volume":" ","pages":""},"PeriodicalIF":14.6,"publicationDate":"2025-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143605995","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A novel brainstem nucleus orchestrating reward and aversion.
IF 14.6 1区 医学
Trends in Neurosciences Pub Date : 2025-03-04 DOI: 10.1016/j.tins.2025.02.002
Min Chen, Hailan Hu
{"title":"A novel brainstem nucleus orchestrating reward and aversion.","authors":"Min Chen, Hailan Hu","doi":"10.1016/j.tins.2025.02.002","DOIUrl":"https://doi.org/10.1016/j.tins.2025.02.002","url":null,"abstract":"<p><p>Reward processing is a critical brain function. Zichó and colleagues recently identified a previously unrecognized brainstem nucleus, the subventricular tegmental nucleus (SVTg), as a novel reward center that modulates dopamine release and regulates reward processing by balancing the lateral habenula (LHb)-ventral tegmental area (VTA) axis.</p>","PeriodicalId":23325,"journal":{"name":"Trends in Neurosciences","volume":" ","pages":""},"PeriodicalIF":14.6,"publicationDate":"2025-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143568400","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Deciphering the role of TYK2 in tau phosphorylation and pathology.
IF 14.6 1区 医学
Trends in Neurosciences Pub Date : 2025-03-01 Epub Date: 2025-02-10 DOI: 10.1016/j.tins.2025.01.004
Alexander Fröhlich, Kathryn R Bowles
{"title":"Deciphering the role of TYK2 in tau phosphorylation and pathology.","authors":"Alexander Fröhlich, Kathryn R Bowles","doi":"10.1016/j.tins.2025.01.004","DOIUrl":"10.1016/j.tins.2025.01.004","url":null,"abstract":"<p><p>Tau phosphorylation plays an essential role in regulating tau's microtubule-stabilizing function, but its hyperphosphorylation drives tauopathies such as Alzheimer's disease (AD). In a recent study, Kim and colleagues decipher that tyrosine kinase 2 (TYK2) phosphorylates tau at tyrosine 29, promoting its stabilization and aggregation by interfering with autophagic clearance, providing novel insights into tau pathology and potential therapeutic strategies.</p>","PeriodicalId":23325,"journal":{"name":"Trends in Neurosciences","volume":" ","pages":"171-173"},"PeriodicalIF":14.6,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143400213","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Elucidating hemodynamics and neuro-glio-vascular signaling using rodent fMRI.
IF 14.6 1区 医学
Trends in Neurosciences Pub Date : 2025-03-01 Epub Date: 2025-01-21 DOI: 10.1016/j.tins.2024.12.010
Xiaoqing Alice Zhou, Yuanyuan Jiang, Lidia Gomez-Cid, Xin Yu
{"title":"Elucidating hemodynamics and neuro-glio-vascular signaling using rodent fMRI.","authors":"Xiaoqing Alice Zhou, Yuanyuan Jiang, Lidia Gomez-Cid, Xin Yu","doi":"10.1016/j.tins.2024.12.010","DOIUrl":"10.1016/j.tins.2024.12.010","url":null,"abstract":"<p><p>Despite extensive functional mapping studies using rodent functional magnetic resonance imaging (fMRI), interpreting the fMRI signals in relation to their neuronal origins remains challenging due to the hemodynamic nature of the response. Ultra high-resolution rodent fMRI, beyond merely enhancing spatial specificity, has revealed vessel-specific hemodynamic responses, highlighting the distinct contributions of intracortical arterioles and venules to fMRI signals. This 'single-vessel' fMRI approach shifts the paradigm of rodent fMRI, enabling its integration with other neuroimaging modalities to investigate neuro-glio-vascular (NGV) signaling underlying a variety of brain dynamics. Here, we review the emerging trend of combining multimodal fMRI with opto/chemogenetic neuromodulation and genetically encoded biosensors for cellular and circuit-specific recording, offering unprecedented opportunities for cross-scale brain dynamic mapping in rodent models.</p>","PeriodicalId":23325,"journal":{"name":"Trends in Neurosciences","volume":" ","pages":"227-241"},"PeriodicalIF":14.6,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11903151/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143024883","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Digestive exophagy as a novel mechanism of amyloid-β degradation by microglial lysosomes.
IF 14.6 1区 医学
Trends in Neurosciences Pub Date : 2025-03-01 Epub Date: 2025-02-13 DOI: 10.1016/j.tins.2025.01.005
Melanie Meyer-Luehmann
{"title":"Digestive exophagy as a novel mechanism of amyloid-β degradation by microglial lysosomes.","authors":"Melanie Meyer-Luehmann","doi":"10.1016/j.tins.2025.01.005","DOIUrl":"10.1016/j.tins.2025.01.005","url":null,"abstract":"<p><p>Microglia are known to be involved in the modulation of amyloid-β (Aβ) plaques in Alzheimer's disease (AD). In a recent study, Jacquet et al. describe how microglia degrade larger Aβ aggregates by forming lysosomal synapses, further implicating the microglial release of lysosomal Aβ, amongst other processes, in the growth and spread of fibrillary Aβ.</p>","PeriodicalId":23325,"journal":{"name":"Trends in Neurosciences","volume":" ","pages":"174-175"},"PeriodicalIF":14.6,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143426474","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Tuning synapse strength by nanocolumn plasticity.
IF 14.6 1区 医学
Trends in Neurosciences Pub Date : 2025-03-01 Epub Date: 2025-01-23 DOI: 10.1016/j.tins.2024.12.009
Na Xu, Si-Yu Chen, Ai-Hui Tang
{"title":"Tuning synapse strength by nanocolumn plasticity.","authors":"Na Xu, Si-Yu Chen, Ai-Hui Tang","doi":"10.1016/j.tins.2024.12.009","DOIUrl":"10.1016/j.tins.2024.12.009","url":null,"abstract":"<p><p>The precise organization of the complex set of synaptic proteins at the nanometer scale is crucial for synaptic transmission. At the heart of this nanoscale architecture lies the nanocolumn. This aligns presynaptic neurotransmitter release with a high local density of postsynaptic receptor channels, thereby optimizing synaptic strength. Although synapses exhibit diverse protein compositions and nanoscale organizations, the role of structural diversity in the notable differences observed in synaptic physiology remains poorly understood. In this review we examine the current literature on the molecular mechanisms underlying the formation and maintenance of nanocolumns, as well as their role in modulating various aspects of synaptic transmission. We also discuss how the reorganization of nanocolumns contributes to functional dynamics in both synaptic plasticity and pathology.</p>","PeriodicalId":23325,"journal":{"name":"Trends in Neurosciences","volume":" ","pages":"200-212"},"PeriodicalIF":14.6,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143029765","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Decoding the rhythmic representation and communication of visual contents. 解码视觉内容的节奏表现与传播。
IF 14.6 1区 医学
Trends in Neurosciences Pub Date : 2025-03-01 Epub Date: 2025-01-15 DOI: 10.1016/j.tins.2024.12.005
Rico Stecher, Radoslaw Martin Cichy, Daniel Kaiser
{"title":"Decoding the rhythmic representation and communication of visual contents.","authors":"Rico Stecher, Radoslaw Martin Cichy, Daniel Kaiser","doi":"10.1016/j.tins.2024.12.005","DOIUrl":"10.1016/j.tins.2024.12.005","url":null,"abstract":"<p><p>Rhythmic neural activity is considered essential for adaptively modulating responses in the visual system. In this opinion article we posit that visual brain rhythms also serve a key function in the representation and communication of visual contents. Collating a set of recent studies that used multivariate decoding methods on rhythmic brain signals, we highlight such rhythmic content representations in visual perception, imagery, and prediction. We argue that characterizing representations across frequency bands allows researchers to elegantly disentangle content transfer in feedforward and feedback directions. We further propose that alpha dynamics are central to content-specific feedback propagation in the visual system. We conclude that considering rhythmic content codes is pivotal for understanding information coding in vision and beyond.</p>","PeriodicalId":23325,"journal":{"name":"Trends in Neurosciences","volume":" ","pages":"178-188"},"PeriodicalIF":14.6,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143012337","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Re-examining the pathobiological basis of gait dysfunction in Parkinson's disease.
IF 14.6 1区 医学
Trends in Neurosciences Pub Date : 2025-03-01 Epub Date: 2025-01-29 DOI: 10.1016/j.tins.2025.01.002
Newton Cho, Lorraine V Kalia, Suneil K Kalia
{"title":"Re-examining the pathobiological basis of gait dysfunction in Parkinson's disease.","authors":"Newton Cho, Lorraine V Kalia, Suneil K Kalia","doi":"10.1016/j.tins.2025.01.002","DOIUrl":"10.1016/j.tins.2025.01.002","url":null,"abstract":"<p><p>Parkinson's disease (PD) is a significant source of morbidity, especially with an aging population. Gait problems, particularly freezing of gait (FOG), remain a persistent issue, causing falls and reduced quality of life without consistent responses to therapies. PD and related symptoms have classically been attributed to dopamine deficiency secondary to substantia nigra degeneration from Lewy body (LB) and Lewy neurite (LN) infiltration. However, Lewy-related pathology is present in other areas of the brainstem and spinal cord that control gait function, yet these other circuits have not been routinely considered in the design of current therapeutic options. In this review, we summarize changes in brainstem and spinal cord circuits in individuals affected by PD and the implications for understanding of gait dysfunction in PD.</p>","PeriodicalId":23325,"journal":{"name":"Trends in Neurosciences","volume":" ","pages":"189-199"},"PeriodicalIF":14.6,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143067581","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Rapid estrogen signaling drives binge drinking.
IF 14.6 1区 医学
Trends in Neurosciences Pub Date : 2025-03-01 Epub Date: 2025-02-20 DOI: 10.1016/j.tins.2025.02.001
Xavier J Maddern, Lauren T Ursich, Leigh C Walker
{"title":"Rapid estrogen signaling drives binge drinking.","authors":"Xavier J Maddern, Lauren T Ursich, Leigh C Walker","doi":"10.1016/j.tins.2025.02.001","DOIUrl":"10.1016/j.tins.2025.02.001","url":null,"abstract":"<p><p>Sex hormones shape behavior through diverse mechanisms. In a recent study, Zallar et al. have uncovered a rapid, nongenomic estrogen signaling pathway mediating binge drinking in female mice via membrane-associated estrogen receptor α (ERα) in the bed nucleus of the stria terminalis (BNST). These findings reveal sex-specific neurobiological underpinnings of alcohol use linked to naturally circulating hormone levels.</p>","PeriodicalId":23325,"journal":{"name":"Trends in Neurosciences","volume":" ","pages":"176-177"},"PeriodicalIF":14.6,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143473121","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Making sense of vertebrate senses from a neural crest and cranial placode evo-devo perspective.
IF 14.6 1区 医学
Trends in Neurosciences Pub Date : 2025-03-01 Epub Date: 2025-01-23 DOI: 10.1016/j.tins.2024.12.008
Brittany M Edens, Marianne E Bronner
{"title":"Making sense of vertebrate senses from a neural crest and cranial placode evo-devo perspective.","authors":"Brittany M Edens, Marianne E Bronner","doi":"10.1016/j.tins.2024.12.008","DOIUrl":"10.1016/j.tins.2024.12.008","url":null,"abstract":"<p><p>The evolution of vertebrates from protochordate ancestors marked the beginning of the gradual transition to predatory lifestyles. Enabled by the acquisition of multipotent neural crest and cranial placode cell populations, vertebrates developed an elaborate peripheral nervous system, equipped with paired sense organs, which aided in adaptive behaviors and ultimately, successful colonization of diverse environmental niches. Underpinning the enduring success of vertebrates is the highly adaptable nature of the peripheral nervous system, which is enabled by the exceptional malleability of the neural crest and placode developmental programs. Here, we explore the embryonic origins of the vertebrate senses from the neural crest and cranial placodes and discuss the evolutionary trajectory of the senses in the context of adaptation to novel environments.</p>","PeriodicalId":23325,"journal":{"name":"Trends in Neurosciences","volume":" ","pages":"213-226"},"PeriodicalIF":14.6,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11903184/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143029760","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
首页 上一页 下一页 尾页
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整，为了账户安全，请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
请完成安全验证×
相关产品
×
本文献相关产品
联系我们：info@booksci.cn Book学术提供免费学术资源搜索服务，方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号：481959085
Book学术官方微信