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Trends in Neurosciences最新文献

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Unweaving type I interferons in age-related neuroinflammation. 解开 I 型干扰素在与年龄相关的神经炎症中的作用。
IF 14.6 1区 医学
Trends in Neurosciences Pub Date : 2024-10-01 Epub Date: 2024-09-04 DOI: 10.1016/j.tins.2024.08.014
David P J Hunt, Markus J Hofer
{"title":"Unweaving type I interferons in age-related neuroinflammation.","authors":"David P J Hunt, Markus J Hofer","doi":"10.1016/j.tins.2024.08.014","DOIUrl":"10.1016/j.tins.2024.08.014","url":null,"abstract":"<p><p>Neuroinflammation is a feature of both neurodegenerative disease and normal brain aging. The roles of type I interferon (IFN-I) in the aged brain are incompletely understood. A recent article by Roy et al. reveals pervasive IFN-I activity in normal mouse brain aging, and highlights the importance of microglial IFN-I signaling in neuroinflammation.</p>","PeriodicalId":23325,"journal":{"name":"Trends in Neurosciences","volume":null,"pages":null},"PeriodicalIF":14.6,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142141214","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
When sensory input meets spontaneous brain activity. 当感官输入与大脑自发活动相遇时。
IF 14.6 1区 医学
Trends in Neurosciences Pub Date : 2024-10-01 Epub Date: 2024-08-31 DOI: 10.1016/j.tins.2024.08.010
Natalia Zaretskaya
{"title":"When sensory input meets spontaneous brain activity.","authors":"Natalia Zaretskaya","doi":"10.1016/j.tins.2024.08.010","DOIUrl":"10.1016/j.tins.2024.08.010","url":null,"abstract":"<p><p>A recent study by Wu, Podvalny, and colleagues investigated how ongoing spontaneous brain activity interacts with sensory input and shapes conscious perception. It reports diverse effects of prestimulus activity in several key networks, revealing new roles of the prefrontal cortex and the default mode network in perception and consciousness.</p>","PeriodicalId":23325,"journal":{"name":"Trends in Neurosciences","volume":null,"pages":null},"PeriodicalIF":14.6,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142112396","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Transformers and cortical waves: encoders for pulling in context across time. 变压器和皮质波：跨时空语境牵引的编码器。
IF 14.6 1区 医学
Trends in Neurosciences Pub Date : 2024-10-01 Epub Date: 2024-09-27 DOI: 10.1016/j.tins.2024.08.006
Lyle Muller, Patricia S Churchland, Terrence J Sejnowski
{"title":"Transformers and cortical waves: encoders for pulling in context across time.","authors":"Lyle Muller, Patricia S Churchland, Terrence J Sejnowski","doi":"10.1016/j.tins.2024.08.006","DOIUrl":"10.1016/j.tins.2024.08.006","url":null,"abstract":"<p><p>The capabilities of transformer networks such as ChatGPT and other large language models (LLMs) have captured the world's attention. The crucial computational mechanism underlying their performance relies on transforming a complete input sequence - for example, all the words in a sentence - into a long 'encoding vector' that allows transformers to learn long-range temporal dependencies in naturalistic sequences. Specifically, 'self-attention' applied to this encoding vector enhances temporal context in transformers by computing associations between pairs of words in the input sequence. We suggest that waves of neural activity traveling across single cortical areas, or multiple regions on the whole-brain scale, could implement a similar encoding principle. By encapsulating recent input history into a single spatial pattern at each moment in time, cortical waves may enable a temporal context to be extracted from sequences of sensory inputs, the same computational principle as that used in transformers.</p>","PeriodicalId":23325,"journal":{"name":"Trends in Neurosciences","volume":null,"pages":null},"PeriodicalIF":14.6,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142354609","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Splenic nociceptive neural connection promotes humoral immunity. 脾脏痛觉神经连接可促进体液免疫。
IF 14.6 1区 医学
Trends in Neurosciences Pub Date : 2024-10-01 DOI: 10.1016/j.tins.2024.09.008
Cheng Qian, Jiaming Wang, Xuetao Cao
{"title":"Splenic nociceptive neural connection promotes humoral immunity.","authors":"Cheng Qian, Jiaming Wang, Xuetao Cao","doi":"10.1016/j.tins.2024.09.008","DOIUrl":"https://doi.org/10.1016/j.tins.2024.09.008","url":null,"abstract":"<p><p>Recent work by Wu and colleagues unveiled a previously enigmatic population of spleen-innervating nociceptors from left T8-T13 dorsal root ganglia (DRGs) in mice. They found a specific DRG-spleen sensorineural connection that promotes humoral immunity via a CGRP-CALCRL/RAMP1 axis, providing a valuable target for immune regulation in local microenvironments.</p>","PeriodicalId":23325,"journal":{"name":"Trends in Neurosciences","volume":null,"pages":null},"PeriodicalIF":14.6,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142366656","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Human-derived monoclonal autoantibodies as interrogators of cellular proteotypes in the brain. 人源单克隆自身抗体作为脑细胞蛋白型的询问因子。
IF 14.6 1区 医学
Trends in Neurosciences Pub Date : 2024-10-01 Epub Date: 2024-09-05 DOI: 10.1016/j.tins.2024.08.004
Matthew L Baum, Christopher M Bartley
{"title":"Human-derived monoclonal autoantibodies as interrogators of cellular proteotypes in the brain.","authors":"Matthew L Baum, Christopher M Bartley","doi":"10.1016/j.tins.2024.08.004","DOIUrl":"10.1016/j.tins.2024.08.004","url":null,"abstract":"<p><p>A major aim of neuroscience is to identify and model the functional properties of neural cells whose dysfunction underlie neuropsychiatric illness. In this article, we propose that human-derived monoclonal autoantibodies (HD-mAbs) are well positioned to selectively target and manipulate neural subpopulations as defined by their protein expression; that is, cellular proteotypes. Recent technical advances allow for efficient cloning of autoantibodies from neuropsychiatric patients. These HD-mAbs can be introduced into animal models to gain biological and pathobiological insights about neural proteotypes of interest. Protein engineering can be used to modify, enhance, silence, or confer new functional properties to native HD-mAbs, thereby enhancing their versatility. Finally, we discuss the challenges and limitations confronting HD-mAbs as experimental research tools for neuroscience.</p>","PeriodicalId":23325,"journal":{"name":"Trends in Neurosciences","volume":null,"pages":null},"PeriodicalIF":14.6,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142146397","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Brain bilateral asymmetry - insights from nematodes, zebrafish, and Drosophila. 大脑双侧不对称--线虫、斑马鱼和果蝇的启示。
IF 14.6 1区 医学
Trends in Neurosciences Pub Date : 2024-10-01 Epub Date: 2024-09-24 DOI: 10.1016/j.tins.2024.08.003
François Lapraz, Cloé Fixary-Schuster, Stéphane Noselli
{"title":"Brain bilateral asymmetry - insights from nematodes, zebrafish, and Drosophila.","authors":"François Lapraz, Cloé Fixary-Schuster, Stéphane Noselli","doi":"10.1016/j.tins.2024.08.003","DOIUrl":"10.1016/j.tins.2024.08.003","url":null,"abstract":"<p><p>Chirality is a fundamental trait of living organisms, encompassing the homochirality of biological molecules and the left-right (LR) asymmetry of visceral organs and the brain. The nervous system in bilaterian organisms displays a lateralized organization characterized by the presence of asymmetrical neuronal circuits and brain functions that are predominantly localized within one hemisphere. Although body asymmetry is relatively well understood, and exhibits robust phenotypic expression and regulation via conserved molecular mechanisms across phyla, current findings indicate that the asymmetry of the nervous system displays greater phenotypic, genetic, and evolutionary variability. In this review we explore the use of nematode, zebrafish, and Drosophila genetic models to investigate neuronal circuit asymmetry. We discuss recent discoveries in the context of body-brain concordance and highlight the distinct characteristics of nervous system asymmetry and its cognitive correlates.</p>","PeriodicalId":23325,"journal":{"name":"Trends in Neurosciences","volume":null,"pages":null},"PeriodicalIF":14.6,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142354605","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Object-oriented olfaction: challenges for chemosensation and for chemosensory research. 面向对象的嗅觉：化学感觉和化学感觉研究面临的挑战。
IF 14.6 1区 医学
Trends in Neurosciences Pub Date : 2024-10-01 Epub Date: 2024-09-07 DOI: 10.1016/j.tins.2024.08.008
Dan Rokni, Yoram Ben-Shaul
{"title":"Object-oriented olfaction: challenges for chemosensation and for chemosensory research.","authors":"Dan Rokni, Yoram Ben-Shaul","doi":"10.1016/j.tins.2024.08.008","DOIUrl":"10.1016/j.tins.2024.08.008","url":null,"abstract":"<p><p>Many animal species use olfaction to extract information about objects in their environment. Yet, the specific molecular signature that any given object emits varies due to various factors. Here, we detail why such variability makes chemosensory-mediated object recognition such a hard problem, and we propose that a major function of the elaborate chemosensory network is to overcome it. We describe previous work addressing different elements of the problem and outline future research directions that we consider essential for a full understanding of object-oriented olfaction. In particular, we call for extensive representation of olfactory object variability in chemical, behavioral, and electrophysiological analyses. While written with an emphasis on macrosmatic mammalian species, our arguments apply to all organisms that employ chemosensation to navigate complex environments.</p>","PeriodicalId":23325,"journal":{"name":"Trends in Neurosciences","volume":null,"pages":null},"PeriodicalIF":14.6,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142155053","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Neural adaptation to changes in self-voice during puberty. 青春期自我声音变化的神经适应。
IF 14.6 1区 医学
Trends in Neurosciences Pub Date : 2024-10-01 Epub Date: 2024-08-29 DOI: 10.1016/j.tins.2024.08.001
Ana P Pinheiro, Jean-Julien Aucouturier, Sonja A Kotz
{"title":"Neural adaptation to changes in self-voice during puberty.","authors":"Ana P Pinheiro, Jean-Julien Aucouturier, Sonja A Kotz","doi":"10.1016/j.tins.2024.08.001","DOIUrl":"10.1016/j.tins.2024.08.001","url":null,"abstract":"<p><p>The human voice is a potent social signal and a distinctive marker of individual identity. As individuals go through puberty, their voices undergo acoustic changes, setting them apart from others. In this article, we propose that hormonal fluctuations in conjunction with morphological vocal tract changes during puberty establish a sensitive developmental phase that affects the monitoring of the adolescent voice and, specifically, self-other distinction. Furthermore, the protracted maturation of brain regions responsible for voice processing, coupled with the dynamically evolving social environment of adolescents, likely disrupts a clear differentiation of the self-voice from others' voices. This socioneuroendocrine framework offers a holistic understanding of voice monitoring during adolescence.</p>","PeriodicalId":23325,"journal":{"name":"Trends in Neurosciences","volume":null,"pages":null},"PeriodicalIF":14.6,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142112395","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Toward actionable neural markers of depression risk? 抑郁症风险的可操作神经标记？
IF 14.6 1区 医学
Trends in Neurosciences Pub Date : 2024-09-27 DOI: 10.1016/j.tins.2024.09.007
Diego A Pizzagalli
{"title":"Toward actionable neural markers of depression risk?","authors":"Diego A Pizzagalli","doi":"10.1016/j.tins.2024.09.007","DOIUrl":"https://doi.org/10.1016/j.tins.2024.09.007","url":null,"abstract":"<p><p>The search for neural markers of depression remains challenging. Despite progress, neuroimaging results have generally not yielded actionable findings that could transform how we understand and treat this disorder. However, in a recent study, Lynch and colleagues identified enlargement of the frontrostriatal salience network as a reproducible, trait-like marker of depression.</p>","PeriodicalId":23325,"journal":{"name":"Trends in Neurosciences","volume":null,"pages":null},"PeriodicalIF":14.6,"publicationDate":"2024-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142354608","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Defining slow wave sleep without slow waves. 定义无慢波睡眠
IF 14.6 1区 医学
Trends in Neurosciences Pub Date : 2024-09-25 DOI: 10.1016/j.tins.2024.09.002
Janna D Lendner, Randolph F Helfrich
{"title":"Defining slow wave sleep without slow waves.","authors":"Janna D Lendner, Randolph F Helfrich","doi":"10.1016/j.tins.2024.09.002","DOIUrl":"https://doi.org/10.1016/j.tins.2024.09.002","url":null,"abstract":"<p><p>Recent research by Parks, Schneider, and colleagues demonstrates that brain states during rodent sleep can be predicted from neural activity on millisecond and micrometer scales. These findings contradict the traditional view that defines sleep by brain-wide oscillations. Instead, this work posits that nonoscillatory activity governs different brain states.</p>","PeriodicalId":23325,"journal":{"name":"Trends in Neurosciences","volume":null,"pages":null},"PeriodicalIF":14.6,"publicationDate":"2024-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142354606","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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