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Advancing ALS research: public-private partnerships to accelerate drug and biomarker development. 推进 ALS 研究：公私合作加快药物和生物标记物的开发。
IF 14.6 1区 医学
Trends in Neurosciences Pub Date : 2025-01-01 Epub Date: 2024-11-21 DOI: 10.1016/j.tins.2024.10.008
Alessio Travaglia, Shubhangi Lal, Sri Ramulu Pullagura
{"title":"Advancing ALS research: public-private partnerships to accelerate drug and biomarker development.","authors":"Alessio Travaglia, Shubhangi Lal, Sri Ramulu Pullagura","doi":"10.1016/j.tins.2024.10.008","DOIUrl":"10.1016/j.tins.2024.10.008","url":null,"abstract":"<p><p>Developing effective treatments for amyotrophic lateral sclerosis (ALS) has been hindered by both the complexity of the disease and decentralized research efforts. By fostering collaboration, standardization, and inclusivity, the Accelerating Medicines Partnership® (AMP®) ALS initiative aims to lay the foundation for future discoveries in ALS biomarkers and treatments.</p>","PeriodicalId":23325,"journal":{"name":"Trends in Neurosciences","volume":" ","pages":"1-2"},"PeriodicalIF":14.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142693702","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cranial motor neuron input specificity refined by activity. 颅运动神经元输入特异性由活动细化。
IF 14.6 1区 医学
Trends in Neurosciences Pub Date : 2025-01-01 Epub Date: 2024-11-29 DOI: 10.1016/j.tins.2024.11.001
Kimberly L McArthur
{"title":"Cranial motor neuron input specificity refined by activity.","authors":"Kimberly L McArthur","doi":"10.1016/j.tins.2024.11.001","DOIUrl":"10.1016/j.tins.2024.11.001","url":null,"abstract":"<p><p>A recent study by Kaneko and colleagues provides evidence that developing cranial motor neurons in larval zebrafish refine their input specificity over time, using an activity-dependent mechanism that may depend, in part, on adaptive dendrite extension. These findings illuminate the mechanism by which spatially overlapping motor pools are recruited into distinct motor circuits.</p>","PeriodicalId":23325,"journal":{"name":"Trends in Neurosciences","volume":" ","pages":"5-6"},"PeriodicalIF":14.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142751826","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Neuronal encoding of behaviors and instrumental learning in the dorsal striatum. 背纹状体中行为和工具学习的神经元编码。
IF 14.6 1区 医学
Trends in Neurosciences Pub Date : 2025-01-01 Epub Date: 2024-12-03 DOI: 10.1016/j.tins.2024.11.003
Christophe Varin, Alban de Kerchove d'Exaerde
{"title":"Neuronal encoding of behaviors and instrumental learning in the dorsal striatum.","authors":"Christophe Varin, Alban de Kerchove d'Exaerde","doi":"10.1016/j.tins.2024.11.003","DOIUrl":"10.1016/j.tins.2024.11.003","url":null,"abstract":"<p><p>The dorsal striatum is instrumental in regulating motor control and goal-directed behaviors. The classical description of the two output pathways of the dorsal striatum highlights their antagonistic control over actions. However, recent experimental evidence implicates both pathways and their coordinated activities during actions. In this review, we examine the different models proposed for striatal encoding of actions during self-paced behaviors and how they can account for evidence harvested during goal-directed behaviors. We also discuss how the activation of striatal ensembles can be reshaped and reorganized to support the formation of instrumental learning and behavioral flexibility. Future work integrating these considerations may resolve controversies regarding the control of actions by striatal networks.</p>","PeriodicalId":23325,"journal":{"name":"Trends in Neurosciences","volume":" ","pages":"77-91"},"PeriodicalIF":14.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142781171","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Where is the error? Hierarchical predictive coding through dendritic error computation: (Trends in Neurosciences 46, 45-59; 2023). 错误在哪里？基于树突误差计算的分层预测编码[j]；2023)。
IF 14.6 1区 医学
Trends in Neurosciences Pub Date : 2025-01-01 Epub Date: 2024-12-05 DOI: 10.1016/j.tins.2024.11.002
Fabian A Mikulasch, Lucas Rudelt, Michael Wibral, Viola Priesemann
{"title":"Where is the error? Hierarchical predictive coding through dendritic error computation: (Trends in Neurosciences 46, 45-59; 2023).","authors":"Fabian A Mikulasch, Lucas Rudelt, Michael Wibral, Viola Priesemann","doi":"10.1016/j.tins.2024.11.002","DOIUrl":"10.1016/j.tins.2024.11.002","url":null,"abstract":"","PeriodicalId":23325,"journal":{"name":"Trends in Neurosciences","volume":" ","pages":"92"},"PeriodicalIF":14.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142792594","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Multiple predictions of others' actions in the human brain. 人脑对他人行为的多重预测
IF 14.6 1区 医学
Trends in Neurosciences Pub Date : 2025-01-01 Epub Date: 2024-11-19 DOI: 10.1016/j.tins.2024.10.009
Yongling Lin, Marco K Wittmann
{"title":"Multiple predictions of others' actions in the human brain.","authors":"Yongling Lin, Marco K Wittmann","doi":"10.1016/j.tins.2024.10.009","DOIUrl":"10.1016/j.tins.2024.10.009","url":null,"abstract":"<p><p>The success of our actions often depends on what others are doing. How does the brain discern predictions of others' actions when situations are ambiguous? Recent work by Ma and colleagues suggests that the brain solves this problem by entertaining multiple predictions of others' actions, ranked by their likelihood.</p>","PeriodicalId":23325,"journal":{"name":"Trends in Neurosciences","volume":" ","pages":"3-4"},"PeriodicalIF":14.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142682798","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The lateral thalamus: a bridge between multisensory processing and naturalistic behaviors. 外侧丘脑：多感觉处理和自然行为之间的桥梁。
IF 14.6 1区 医学
Trends in Neurosciences Pub Date : 2025-01-01 Epub Date: 2024-12-12 DOI: 10.1016/j.tins.2024.11.005
Mingyu Yang, Dávid Keller, Arpád Dobolyi, Silvana Valtcheva
{"title":"The lateral thalamus: a bridge between multisensory processing and naturalistic behaviors.","authors":"Mingyu Yang, Dávid Keller, Arpád Dobolyi, Silvana Valtcheva","doi":"10.1016/j.tins.2024.11.005","DOIUrl":"10.1016/j.tins.2024.11.005","url":null,"abstract":"<p><p>The lateral thalamus (LT) receives input from primary sensory nuclei and responds to multimodal stimuli. The LT is also involved in regulating innate and social behaviors through its projections to cortical and limbic networks. However, the importance of multisensory processing within the LT in modulating behavioral output has not been explicitly addressed. Here, we discuss recent findings primarily from rodent studies that extend the classical view of the LT as a passive relay, by underscoring its involvement in associating multimodal features and encoding the salience, valence, and social relevance of sensory signals. We propose that the primary function of the LT is to integrate sensory and non-sensory aspects of multisensory input to gate naturalistic behaviors.</p>","PeriodicalId":23325,"journal":{"name":"Trends in Neurosciences","volume":" ","pages":"33-46"},"PeriodicalIF":14.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142822720","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Development and function of the medial amygdala. 内侧杏仁核的发育和功能。
IF 14.6 1区 医学
Trends in Neurosciences Pub Date : 2025-01-01 Epub Date: 2024-12-12 DOI: 10.1016/j.tins.2024.11.004
Nandkishore Prakash, Ameair Abu Irqeba, Joshua G Corbin
{"title":"Development and function of the medial amygdala.","authors":"Nandkishore Prakash, Ameair Abu Irqeba, Joshua G Corbin","doi":"10.1016/j.tins.2024.11.004","DOIUrl":"10.1016/j.tins.2024.11.004","url":null,"abstract":"<p><p>Across studied vertebrates, the medial amygdala (MeA) is a central hub for relaying sensory information with social and/or survival relevance to downstream nuclei such as the bed nucleus of stria terminalis (BNST) and the hypothalamus. MeA-driven behaviors, such as mating, aggression, parenting, and predator avoidance are processed by different molecularly defined inhibitory and excitatory neuronal output populations. Work over the past two decades has deciphered how diverse MeA neurons arise from embryonic development, revealing contributions from multiple telencephalic and diencephalic progenitor domains. Here, we first provide a brief overview of current findings regarding the role of the MeA in social behaviors, followed by a deeper dive into current knowledge of how this complex structure is specified during development. We outline a conceptual model of MeA formation that has emerged based on these findings. We further postulate how embryonic developmental programming of the MeA may inform later emergence of stereotypical circuitry governing hardwired behaviors.</p>","PeriodicalId":23325,"journal":{"name":"Trends in Neurosciences","volume":" ","pages":"22-32"},"PeriodicalIF":14.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142822719","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Understanding GABAergic synapse diversity and its implications for GABAergic pharmacotherapy. 了解gaba能突触多样性及其对gaba能药物治疗的意义。
IF 14.6 1区 医学
Trends in Neurosciences Pub Date : 2025-01-01 Epub Date: 2025-01-08 DOI: 10.1016/j.tins.2024.11.007
Dilja Krueger-Burg
{"title":"Understanding GABAergic synapse diversity and its implications for GABAergic pharmacotherapy.","authors":"Dilja Krueger-Burg","doi":"10.1016/j.tins.2024.11.007","DOIUrl":"10.1016/j.tins.2024.11.007","url":null,"abstract":"<p><p>Despite the substantial contribution of disruptions in GABAergic inhibitory neurotransmission to the etiology of psychiatric, neurodevelopmental, and neurodegenerative disorders, surprisingly few drugs targeting the GABAergic system are currently available, partly due to insufficient understanding of circuit-specific GABAergic synapse biology. In addition to GABA receptors, GABAergic synapses contain an elaborate organizational protein machinery that regulates the properties of synaptic transmission. Until recently, this machinery remained largely unexplored, but key methodological advances have now led to the identification of a wealth of new GABAergic organizer proteins. Notably, many of these proteins appear to function only at specific subsets of GABAergic synapses, creating a diversity of organizer complexes that may serve as circuit-specific targets for pharmacotherapies. The present review aims to summarize the methodological developments that underlie this newfound knowledge and provide a current overview of synapse-specific GABAergic organizer complexes, as well as outlining future avenues and challenges in translating this knowledge into clinical applications.</p>","PeriodicalId":23325,"journal":{"name":"Trends in Neurosciences","volume":" ","pages":"47-61"},"PeriodicalIF":14.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142955559","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Is the impact of spontaneous movements on early visual cortex species specific? 自发运动对早期视觉皮层的影响是物种特异性的吗？
IF 14.6 1区 医学
Trends in Neurosciences Pub Date : 2025-01-01 Epub Date: 2024-12-18 DOI: 10.1016/j.tins.2024.11.006
Incheol Kang, Bharath Chandra Talluri, Jacob L Yates, Cristopher M Niell, Hendrikje Nienborg
{"title":"Is the impact of spontaneous movements on early visual cortex species specific?","authors":"Incheol Kang, Bharath Chandra Talluri, Jacob L Yates, Cristopher M Niell, Hendrikje Nienborg","doi":"10.1016/j.tins.2024.11.006","DOIUrl":"10.1016/j.tins.2024.11.006","url":null,"abstract":"<p><p>Recent studies in non-human primates do not find pronounced signals related to the animal's own body movements in the responses of neurons in the visual cortex. This is notable because such pronounced signals have been widely observed in the visual cortex of mice. Here, we discuss factors that may contribute to the differences observed between species, such as state, slow neural drift, eccentricity, and changes in retinal input. The interpretation of movement-related signals in the visual cortex also exemplifies the challenge of identifying the sources of correlated variables. Dissecting these sources is central for understanding the functional roles of movement-related signals. We suggest a functional classification of the possible sources, aimed at facilitating cross-species comparative approaches to studying the neural mechanisms of vision during natural behavior.</p>","PeriodicalId":23325,"journal":{"name":"Trends in Neurosciences","volume":" ","pages":"7-21"},"PeriodicalIF":14.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11741931/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142865588","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The intertwined relationship between circadian dysfunction and Parkinson's disease. 昼夜节律失调与帕金森病之间的相互交织关系。
IF 14.6 1区 医学
Trends in Neurosciences Pub Date : 2025-01-01 Epub Date: 2024-11-21 DOI: 10.1016/j.tins.2024.10.006
Lou C Duret, Emi Nagoshi
{"title":"The intertwined relationship between circadian dysfunction and Parkinson's disease.","authors":"Lou C Duret, Emi Nagoshi","doi":"10.1016/j.tins.2024.10.006","DOIUrl":"10.1016/j.tins.2024.10.006","url":null,"abstract":"<p><p>Neurodegenerative disorders represent a leading cause of disability among the elderly population, and Parkinson's disease (PD) is the second most prevalent. Emerging evidence suggests a frequent co-occurrence of circadian disruption and PD. However, the nature of this relationship remains unclear: is circadian disruption a cause, consequence, or a parallel feature of the disease that shares the same root cause? This review seeks to address this question by highlighting and discussing clinical evidence and findings from experiments using vertebrate and invertebrate animal models. While research on causality is still in its early stages, the available data suggest reciprocal interactions between PD progression and circadian disruption.</p>","PeriodicalId":23325,"journal":{"name":"Trends in Neurosciences","volume":" ","pages":"62-76"},"PeriodicalIF":14.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142693703","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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