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TDP-43 nuclear condensation and neurodegenerative proteinopathies. TDP-43 核凝聚与神经退行性蛋白病。
IF 14.6 1区 医学
Trends in Neurosciences Pub Date : 2024-11-01 Epub Date: 2024-09-25 DOI: 10.1016/j.tins.2024.09.003
Florencia Vassallu, Lionel M Igaz
{"title":"TDP-43 nuclear condensation and neurodegenerative proteinopathies.","authors":"Florencia Vassallu, Lionel M Igaz","doi":"10.1016/j.tins.2024.09.003","DOIUrl":"10.1016/j.tins.2024.09.003","url":null,"abstract":"<p><p>RNA-binding proteins (RBPs) can undergo phase separation and form condensates, processes that, in turn, can be critical for their functionality. In a recent study, Huang, Ellis, and colleagues show that cellular stress can trigger transient alterations in nuclear TAR DNA-binding protein 43 (TDP-43), leading to changes crucial for proper neuronal function. These findings have implications for understanding neurological TDP-43 proteinopathies.</p>","PeriodicalId":23325,"journal":{"name":"Trends in Neurosciences","volume":" ","pages":"849-850"},"PeriodicalIF":14.6,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142354607","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Principles of intensive human neuroimaging. 强化人类神经成像原理
IF 14.6 1区 医学
Trends in Neurosciences Pub Date : 2024-11-01 Epub Date: 2024-10-24 DOI: 10.1016/j.tins.2024.09.011
Eline R Kupers, Tomas Knapen, Elisha P Merriam, Kendrick N Kay
{"title":"Principles of intensive human neuroimaging.","authors":"Eline R Kupers, Tomas Knapen, Elisha P Merriam, Kendrick N Kay","doi":"10.1016/j.tins.2024.09.011","DOIUrl":"10.1016/j.tins.2024.09.011","url":null,"abstract":"<p><p>The rise of large, publicly shared functional magnetic resonance imaging (fMRI) data sets in human neuroscience has focused on acquiring either a few hours of data on many individuals ('wide' fMRI) or many hours of data on a few individuals ('deep' fMRI). In this opinion article, we highlight an emerging approach within deep fMRI, which we refer to as 'intensive' fMRI: one that strives for extensive sampling of cognitive phenomena to support computational modeling and detailed investigation of brain function at the single voxel level. We discuss the fundamental principles, trade-offs, and practical considerations of intensive fMRI. We also emphasize that intensive fMRI does not simply mean collecting more data: it requires careful design of experiments to enable a rich hypothesis space, optimizing data quality, and strategically curating public resources to maximize community impact.</p>","PeriodicalId":23325,"journal":{"name":"Trends in Neurosciences","volume":" ","pages":"856-864"},"PeriodicalIF":14.6,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11563852/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142508799","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Examining resilience to Alzheimer's disease through the lens of monoaminergic neuromodulator systems. 从单胺类神经调节系统的角度研究阿尔茨海默氏症的恢复能力。
IF 14.6 1区 医学
Trends in Neurosciences Pub Date : 2024-11-01 Epub Date: 2024-10-04 DOI: 10.1016/j.tins.2024.09.004
Jennifer L Crawford, Anne S Berry
{"title":"Examining resilience to Alzheimer's disease through the lens of monoaminergic neuromodulator systems.","authors":"Jennifer L Crawford, Anne S Berry","doi":"10.1016/j.tins.2024.09.004","DOIUrl":"10.1016/j.tins.2024.09.004","url":null,"abstract":"<p><p>The monoaminergic nuclei are thought to be some of the earliest sites of Alzheimer's disease (AD) pathology in the brain, with tau-containing pretangles appearing in these nuclei decades before the onset of clinical impairments. It has increasingly been recognized that monoamine systems represent a critical target of investigation towards understanding the progression of AD and designing early detection and treatment approaches. This review synthesizes evidence across animal studies, human neuropathology, and state-of-the-art neuroimaging and daily life assessment methods in humans, which demonstrate robust relationships between monoamine systems and AD pathophysiology and behavior. Further, the review highlights the promise of multimethod, multisystem approaches to studying monoaminergic mechanisms of resilience to AD pathology.</p>","PeriodicalId":23325,"journal":{"name":"Trends in Neurosciences","volume":" ","pages":"892-903"},"PeriodicalIF":14.6,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11563896/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142378256","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Toward actionable neural markers of depression risk? 抑郁症风险的可操作神经标记？
IF 14.6 1区 医学
Trends in Neurosciences Pub Date : 2024-11-01 Epub Date: 2024-09-27 DOI: 10.1016/j.tins.2024.09.007
Diego A Pizzagalli
{"title":"Toward actionable neural markers of depression risk?","authors":"Diego A Pizzagalli","doi":"10.1016/j.tins.2024.09.007","DOIUrl":"10.1016/j.tins.2024.09.007","url":null,"abstract":"<p><p>The search for neural markers of depression remains challenging. Despite progress, neuroimaging results have generally not yielded actionable findings that could transform how we understand and treat this disorder. However, in a recent study, Lynch and colleagues identified enlargement of the frontrostriatal salience network as a reproducible, trait-like marker of depression.</p>","PeriodicalId":23325,"journal":{"name":"Trends in Neurosciences","volume":" ","pages":"851-852"},"PeriodicalIF":14.6,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11563912/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142354608","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Dopaminergic circuits controlling threat and safety learning. 控制威胁和安全学习的多巴胺能回路
IF 14.6 1区 医学
Trends in Neurosciences Pub Date : 2024-10-28 DOI: 10.1016/j.tins.2024.10.001
Sevil Duvarci
{"title":"Dopaminergic circuits controlling threat and safety learning.","authors":"Sevil Duvarci","doi":"10.1016/j.tins.2024.10.001","DOIUrl":"https://doi.org/10.1016/j.tins.2024.10.001","url":null,"abstract":"<p><p>The ability to learn from experience that certain cues and situations are associated with threats or safety is crucial for survival and adaptive behavior. Understanding the neural substrates of threat and safety learning has high clinical significance because deficits in these forms of learning characterize anxiety disorders. Traditionally, dopamine neurons were thought to uniformly support reward learning by signaling reward prediction errors. However, the dopamine system is functionally more diverse than was initially appreciated and is also critical for processing threat and safety. In this review, I highlight recent studies demonstrating that dopamine neurons generate prediction errors for threat and safety, and describe how dopamine projections to the amygdala, medial prefrontal cortex (mPFC), and striatum regulate associative threat and safety learning.</p>","PeriodicalId":23325,"journal":{"name":"Trends in Neurosciences","volume":" ","pages":""},"PeriodicalIF":14.6,"publicationDate":"2024-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142547690","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Retinal ganglion cell circuits and glial interactions in humans and mice. 人类和小鼠的视网膜神经节细胞回路和神经胶质相互作用。
IF 14.6 1区 医学
Trends in Neurosciences Pub Date : 2024-10-24 DOI: 10.1016/j.tins.2024.09.010
Kang-Chieh Huang, Mohamed Tawfik, Melanie A Samuel
{"title":"Retinal ganglion cell circuits and glial interactions in humans and mice.","authors":"Kang-Chieh Huang, Mohamed Tawfik, Melanie A Samuel","doi":"10.1016/j.tins.2024.09.010","DOIUrl":"https://doi.org/10.1016/j.tins.2024.09.010","url":null,"abstract":"<p><p>Retinal ganglion cells (RGCs) are the brain's gateway for vision, and their degeneration underlies several blinding diseases. RGCs interact with other neuronal cell types, microglia, and astrocytes in the retina and in the brain. Much knowledge has been gained about RGCs and glia from mice and other model organisms, often with the assumption that certain aspects of their biology may be conserved in humans. However, RGCs vary considerably between species, which could affect how they interact with their neuronal and glial partners. This review details which RGC and glial features are conserved between mice, humans, and primates, and which differ. We also discuss experimental approaches for studying human and primate RGCs. These strategies will help to bridge the gap between rodent and human RGC studies and increase study translatability to guide future therapeutic strategies.</p>","PeriodicalId":23325,"journal":{"name":"Trends in Neurosciences","volume":" ","pages":""},"PeriodicalIF":14.6,"publicationDate":"2024-10-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142508800","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
CAMs in command: aging brain macrophages fine-tune stroke immune responses. CAMs指挥：衰老的脑巨噬细胞可微调中风免疫反应。
IF 14.6 1区 医学
Trends in Neurosciences Pub Date : 2024-10-22 DOI: 10.1016/j.tins.2024.10.002
Rodney M Ritzel, Danye Jiang, Louise D McCullough
{"title":"CAMs in command: aging brain macrophages fine-tune stroke immune responses.","authors":"Rodney M Ritzel, Danye Jiang, Louise D McCullough","doi":"10.1016/j.tins.2024.10.002","DOIUrl":"https://doi.org/10.1016/j.tins.2024.10.002","url":null,"abstract":"<p><p>Central nervous system-associated macrophages (CAMs) are a unique subset of immune cells located at the interface between the blood and the brain parenchyma. In a recent study in mice, Levard and colleagues found that CAMs regulate immune cell trafficking, endothelial activation, and antigen presentation following stroke exclusively in aged animals, underscoring the importance of using translationally relevant models for studying age-related diseases.</p>","PeriodicalId":23325,"journal":{"name":"Trends in Neurosciences","volume":" ","pages":""},"PeriodicalIF":14.6,"publicationDate":"2024-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142508798","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Defining and characterizing neuronal senescence, 'neurescence', as GX arrested cells. 将神经元衰老（"神经衰老"）定义为 GX 停止细胞，并确定其特征。
IF 14.6 1区 医学
Trends in Neurosciences Pub Date : 2024-10-09 DOI: 10.1016/j.tins.2024.09.006
Hannah R Hudson, Markus Riessland, Miranda E Orr
{"title":"Defining and characterizing neuronal senescence, 'neurescence', as G<sub>X</sub> arrested cells.","authors":"Hannah R Hudson, Markus Riessland, Miranda E Orr","doi":"10.1016/j.tins.2024.09.006","DOIUrl":"https://doi.org/10.1016/j.tins.2024.09.006","url":null,"abstract":"<p><p>Cellular senescence is a cell state characterized by resistance to apoptosis and stable cell cycle arrest. Senescence was first observed in mitotic cells in vitro. Recent evidence from in vivo studies and human tissue indicates that postmitotic cells, including neurons, may also become senescent. The quiescent cell state of neurons and inconsistent descriptions of neuronal senescence across studies, however, have caused confusion in this burgeoning field. We summarize evidence demonstrating that exit from G<sub>0</sub> quiescence may protect neurons against apoptosis and predispose them toward senescence. Additionally, we propose the term 'neurescent' for senescent neurons and introduce the cell state, G<sub>X</sub>, to describe cell cycle arrest achieved by passing through G<sub>0</sub> quiescence. Criteria are provided to identify neurescent cells, distinguish them from G<sub>0</sub> quiescent neurons, and compare neurescent phenotypes with classic replicative senescence.</p>","PeriodicalId":23325,"journal":{"name":"Trends in Neurosciences","volume":" ","pages":""},"PeriodicalIF":14.6,"publicationDate":"2024-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142401437","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Unweaving type I interferons in age-related neuroinflammation. 解开 I 型干扰素在与年龄相关的神经炎症中的作用。
IF 14.6 1区 医学
Trends in Neurosciences Pub Date : 2024-10-01 Epub Date: 2024-09-04 DOI: 10.1016/j.tins.2024.08.014
David P J Hunt, Markus J Hofer
{"title":"Unweaving type I interferons in age-related neuroinflammation.","authors":"David P J Hunt, Markus J Hofer","doi":"10.1016/j.tins.2024.08.014","DOIUrl":"10.1016/j.tins.2024.08.014","url":null,"abstract":"<p><p>Neuroinflammation is a feature of both neurodegenerative disease and normal brain aging. The roles of type I interferon (IFN-I) in the aged brain are incompletely understood. A recent article by Roy et al. reveals pervasive IFN-I activity in normal mouse brain aging, and highlights the importance of microglial IFN-I signaling in neuroinflammation.</p>","PeriodicalId":23325,"journal":{"name":"Trends in Neurosciences","volume":" ","pages":"751-752"},"PeriodicalIF":14.6,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142141214","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
When sensory input meets spontaneous brain activity. 当感官输入与大脑自发活动相遇时。
IF 14.6 1区 医学
Trends in Neurosciences Pub Date : 2024-10-01 Epub Date: 2024-08-31 DOI: 10.1016/j.tins.2024.08.010
Natalia Zaretskaya
{"title":"When sensory input meets spontaneous brain activity.","authors":"Natalia Zaretskaya","doi":"10.1016/j.tins.2024.08.010","DOIUrl":"10.1016/j.tins.2024.08.010","url":null,"abstract":"<p><p>A recent study by Wu, Podvalny, and colleagues investigated how ongoing spontaneous brain activity interacts with sensory input and shapes conscious perception. It reports diverse effects of prestimulus activity in several key networks, revealing new roles of the prefrontal cortex and the default mode network in perception and consciousness.</p>","PeriodicalId":23325,"journal":{"name":"Trends in Neurosciences","volume":" ","pages":"749-750"},"PeriodicalIF":14.6,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142112396","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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