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Origins of food selectivity in human visual cortex.
IF 14.6 1区 医学
Trends in Neurosciences Pub Date : 2025-02-01 DOI: 10.1016/j.tins.2024.12.001
Margaret M Henderson, Michael J Tarr, Leila Wehbe
{"title":"Origins of food selectivity in human visual cortex.","authors":"Margaret M Henderson, Michael J Tarr, Leila Wehbe","doi":"10.1016/j.tins.2024.12.001","DOIUrl":"10.1016/j.tins.2024.12.001","url":null,"abstract":"<p><p>Several recent studies, enabled by advances in neuroimaging methods and large-scale datasets, have identified areas in human ventral visual cortex that respond more strongly to food images than to images of many other categories, adding to our knowledge about the broad network of regions that are responsive to food. This finding raises important questions about the evolutionary and developmental origins of a possible food-selective neural population, as well as larger questions about the origins of category-selective neural populations more generally. Here, we propose a framework for how visual properties of food (particularly color) and nonvisual signals associated with multimodal reward processing, social cognition, and physical interactions with food may, in combination, contribute to the emergence of food selectivity. We discuss recent research that sheds light on each of these factors, alongside a broader account of category selectivity that incorporates both visual feature statistics and behavioral relevance.</p>","PeriodicalId":23325,"journal":{"name":"Trends in Neurosciences","volume":" ","pages":"113-123"},"PeriodicalIF":14.6,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143075536","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Metacognition in the listening brain.
IF 14.6 1区 医学
Trends in Neurosciences Pub Date : 2025-02-01 Epub Date: 2025-01-21 DOI: 10.1016/j.tins.2024.12.007
Jonas Obleser
{"title":"Metacognition in the listening brain.","authors":"Jonas Obleser","doi":"10.1016/j.tins.2024.12.007","DOIUrl":"10.1016/j.tins.2024.12.007","url":null,"abstract":"<p><p>How do you know you have heard right? Metacognition, the ability to assess and monitor one's own cognitive state, is key to understanding human communication in complex environments. However, the foundational role of metacognition in hearing and communication is only beginning to be explored, and the neuroscience behind it is an emerging field: how does confidence express in neural dynamics of the listening brain? What is known about auditory metaperceptual alterations as a hallmark phenomenon in psychosis, dementia, or hearing loss? Building on Bayesian ideas of auditory perception and auditory neuroscience, 'meta-listening' offers a framework for more comprehensive research into how metacognition in humans and non-humans shapes the listening brain.</p>","PeriodicalId":23325,"journal":{"name":"Trends in Neurosciences","volume":" ","pages":"100-112"},"PeriodicalIF":14.6,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143024892","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Re-examining the pathobiological basis of gait dysfunction in Parkinson's disease.
IF 14.6 1区 医学
Trends in Neurosciences Pub Date : 2025-01-29 DOI: 10.1016/j.tins.2025.01.002
Newton Cho, Lorraine V Kalia, Suneil K Kalia
{"title":"Re-examining the pathobiological basis of gait dysfunction in Parkinson's disease.","authors":"Newton Cho, Lorraine V Kalia, Suneil K Kalia","doi":"10.1016/j.tins.2025.01.002","DOIUrl":"https://doi.org/10.1016/j.tins.2025.01.002","url":null,"abstract":"<p><p>Parkinson's disease (PD) is a significant source of morbidity, especially with an aging population. Gait problems, particularly freezing of gait (FOG), remain a persistent issue, causing falls and reduced quality of life without consistent responses to therapies. PD and related symptoms have classically been attributed to dopamine deficiency secondary to substantia nigra degeneration from Lewy body (LB) and Lewy neurite (LN) infiltration. However, Lewy-related pathology is present in other areas of the brainstem and spinal cord that control gait function, yet these other circuits have not been routinely considered in the design of current therapeutic options. In this review, we summarize changes in brainstem and spinal cord circuits in individuals affected by PD and the implications for understanding of gait dysfunction in PD.</p>","PeriodicalId":23325,"journal":{"name":"Trends in Neurosciences","volume":" ","pages":""},"PeriodicalIF":14.6,"publicationDate":"2025-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143067581","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Tuning synapse strength by nanocolumn plasticity.
IF 14.6 1区 医学
Trends in Neurosciences Pub Date : 2025-01-22 DOI: 10.1016/j.tins.2024.12.009
Na Xu, Si-Yu Chen, Ai-Hui Tang
{"title":"Tuning synapse strength by nanocolumn plasticity.","authors":"Na Xu, Si-Yu Chen, Ai-Hui Tang","doi":"10.1016/j.tins.2024.12.009","DOIUrl":"https://doi.org/10.1016/j.tins.2024.12.009","url":null,"abstract":"<p><p>The precise organization of the complex set of synaptic proteins at the nanometer scale is crucial for synaptic transmission. At the heart of this nanoscale architecture lies the nanocolumn. This aligns presynaptic neurotransmitter release with a high local density of postsynaptic receptor channels, thereby optimizing synaptic strength. Although synapses exhibit diverse protein compositions and nanoscale organizations, the role of structural diversity in the notable differences observed in synaptic physiology remains poorly understood. In this review we examine the current literature on the molecular mechanisms underlying the formation and maintenance of nanocolumns, as well as their role in modulating various aspects of synaptic transmission. We also discuss how the reorganization of nanocolumns contributes to functional dynamics in both synaptic plasticity and pathology.</p>","PeriodicalId":23325,"journal":{"name":"Trends in Neurosciences","volume":" ","pages":""},"PeriodicalIF":14.6,"publicationDate":"2025-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143029765","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Mechanistic insights into chemotherapy-induced circadian disruption using rodent models.
IF 14.6 1区 医学
Trends in Neurosciences Pub Date : 2025-01-22 DOI: 10.1016/j.tins.2024.12.011
Zoe M Tapp, Amiya K Ghosh, Karl H Obrietan, Leah M Pyter
{"title":"Mechanistic insights into chemotherapy-induced circadian disruption using rodent models.","authors":"Zoe M Tapp, Amiya K Ghosh, Karl H Obrietan, Leah M Pyter","doi":"10.1016/j.tins.2024.12.011","DOIUrl":"https://doi.org/10.1016/j.tins.2024.12.011","url":null,"abstract":"<p><p>Chemotherapy treatment can significantly increase the survival of patients with cancer, but it also causes collateral damage in the body that can lead to treatment dose reductions and can reduce patient quality of life. One understudied side effect of chemotherapy is circadian disruption, which is associated with lasting biological and behavioral toxicities. Mechanisms of how chemotherapy alters circadian rhythms remain largely unknown, although leveraging rodent models may provide insights into causes and consequences of this disruption. Here, we review physiological, molecular, and behavioral evidence of central and peripheral circadian disruption in various rodent models of chemotherapy and discuss possible mechanisms driving these circadian disruptions. Overall, restoring circadian rhythms following treatment-induced disruptions may be a novel target by which to improve the health and quality of life of survivors.</p>","PeriodicalId":23325,"journal":{"name":"Trends in Neurosciences","volume":" ","pages":""},"PeriodicalIF":14.6,"publicationDate":"2025-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143024889","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Making sense of vertebrate senses from a neural crest and cranial placode evo-devo perspective.
IF 14.6 1区 医学
Trends in Neurosciences Pub Date : 2025-01-22 DOI: 10.1016/j.tins.2024.12.008
Brittany M Edens, Marianne E Bronner
{"title":"Making sense of vertebrate senses from a neural crest and cranial placode evo-devo perspective.","authors":"Brittany M Edens, Marianne E Bronner","doi":"10.1016/j.tins.2024.12.008","DOIUrl":"https://doi.org/10.1016/j.tins.2024.12.008","url":null,"abstract":"<p><p>The evolution of vertebrates from protochordate ancestors marked the beginning of the gradual transition to predatory lifestyles. Enabled by the acquisition of multipotent neural crest and cranial placode cell populations, vertebrates developed an elaborate peripheral nervous system, equipped with paired sense organs, which aided in adaptive behaviors and ultimately, successful colonization of diverse environmental niches. Underpinning the enduring success of vertebrates is the highly adaptable nature of the peripheral nervous system, which is enabled by the exceptional malleability of the neural crest and placode developmental programs. Here, we explore the embryonic origins of the vertebrate senses from the neural crest and cranial placodes and discuss the evolutionary trajectory of the senses in the context of adaptation to novel environments.</p>","PeriodicalId":23325,"journal":{"name":"Trends in Neurosciences","volume":" ","pages":""},"PeriodicalIF":14.6,"publicationDate":"2025-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143029760","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Elucidating hemodynamics and neuro-glio-vascular signaling using rodent fMRI.
IF 14.6 1区 医学
Trends in Neurosciences Pub Date : 2025-01-21 DOI: 10.1016/j.tins.2024.12.010
Xiaoqing Alice Zhou, Yuanyuan Jiang, Lidia Gomez-Cid, Xin Yu
{"title":"Elucidating hemodynamics and neuro-glio-vascular signaling using rodent fMRI.","authors":"Xiaoqing Alice Zhou, Yuanyuan Jiang, Lidia Gomez-Cid, Xin Yu","doi":"10.1016/j.tins.2024.12.010","DOIUrl":"10.1016/j.tins.2024.12.010","url":null,"abstract":"<p><p>Despite extensive functional mapping studies using rodent functional magnetic resonance imaging (fMRI), interpreting the fMRI signals in relation to their neuronal origins remains challenging due to the hemodynamic nature of the response. Ultra high-resolution rodent fMRI, beyond merely enhancing spatial specificity, has revealed vessel-specific hemodynamic responses, highlighting the distinct contributions of intracortical arterioles and venules to fMRI signals. This 'single-vessel' fMRI approach shifts the paradigm of rodent fMRI, enabling its integration with other neuroimaging modalities to investigate neuro-glio-vascular (NGV) signaling underlying a variety of brain dynamics. Here, we review the emerging trend of combining multimodal fMRI with opto/chemogenetic neuromodulation and genetically encoded biosensors for cellular and circuit-specific recording, offering unprecedented opportunities for cross-scale brain dynamic mapping in rodent models.</p>","PeriodicalId":23325,"journal":{"name":"Trends in Neurosciences","volume":" ","pages":""},"PeriodicalIF":14.6,"publicationDate":"2025-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143024883","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Decoding the rhythmic representation and communication of visual contents. 解码视觉内容的节奏表现与传播。
IF 14.6 1区 医学
Trends in Neurosciences Pub Date : 2025-01-15 DOI: 10.1016/j.tins.2024.12.005
Rico Stecher, Radoslaw Martin Cichy, Daniel Kaiser
{"title":"Decoding the rhythmic representation and communication of visual contents.","authors":"Rico Stecher, Radoslaw Martin Cichy, Daniel Kaiser","doi":"10.1016/j.tins.2024.12.005","DOIUrl":"https://doi.org/10.1016/j.tins.2024.12.005","url":null,"abstract":"<p><p>Rhythmic neural activity is considered essential for adaptively modulating responses in the visual system. In this opinion article we posit that visual brain rhythms also serve a key function in the representation and communication of visual contents. Collating a set of recent studies that used multivariate decoding methods on rhythmic brain signals, we highlight such rhythmic content representations in visual perception, imagery, and prediction. We argue that characterizing representations across frequency bands allows researchers to elegantly disentangle content transfer in feedforward and feedback directions. We further propose that alpha dynamics are central to content-specific feedback propagation in the visual system. We conclude that considering rhythmic content codes is pivotal for understanding information coding in vision and beyond.</p>","PeriodicalId":23325,"journal":{"name":"Trends in Neurosciences","volume":" ","pages":""},"PeriodicalIF":14.6,"publicationDate":"2025-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143012337","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Advancing ALS research: public-private partnerships to accelerate drug and biomarker development. 推进 ALS 研究：公私合作加快药物和生物标记物的开发。
IF 14.6 1区 医学
Trends in Neurosciences Pub Date : 2025-01-01 Epub Date: 2024-11-21 DOI: 10.1016/j.tins.2024.10.008
Alessio Travaglia, Shubhangi Lal, Sri Ramulu Pullagura
{"title":"Advancing ALS research: public-private partnerships to accelerate drug and biomarker development.","authors":"Alessio Travaglia, Shubhangi Lal, Sri Ramulu Pullagura","doi":"10.1016/j.tins.2024.10.008","DOIUrl":"10.1016/j.tins.2024.10.008","url":null,"abstract":"<p><p>Developing effective treatments for amyotrophic lateral sclerosis (ALS) has been hindered by both the complexity of the disease and decentralized research efforts. By fostering collaboration, standardization, and inclusivity, the Accelerating Medicines Partnership® (AMP®) ALS initiative aims to lay the foundation for future discoveries in ALS biomarkers and treatments.</p>","PeriodicalId":23325,"journal":{"name":"Trends in Neurosciences","volume":" ","pages":"1-2"},"PeriodicalIF":14.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142693702","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cranial motor neuron input specificity refined by activity. 颅运动神经元输入特异性由活动细化。
IF 14.6 1区 医学
Trends in Neurosciences Pub Date : 2025-01-01 Epub Date: 2024-11-29 DOI: 10.1016/j.tins.2024.11.001
Kimberly L McArthur
{"title":"Cranial motor neuron input specificity refined by activity.","authors":"Kimberly L McArthur","doi":"10.1016/j.tins.2024.11.001","DOIUrl":"10.1016/j.tins.2024.11.001","url":null,"abstract":"<p><p>A recent study by Kaneko and colleagues provides evidence that developing cranial motor neurons in larval zebrafish refine their input specificity over time, using an activity-dependent mechanism that may depend, in part, on adaptive dendrite extension. These findings illuminate the mechanism by which spatially overlapping motor pools are recruited into distinct motor circuits.</p>","PeriodicalId":23325,"journal":{"name":"Trends in Neurosciences","volume":" ","pages":"5-6"},"PeriodicalIF":14.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142751826","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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