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Local translation under epitranscriptomic control. 表转录组控制下的局部翻译。
IF 15.1 1区 医学
Trends in Neurosciences Pub Date : 2025-09-30 DOI: 10.1016/j.tins.2025.09.005
José R Sotelo-Silveira
{"title":"Local translation under epitranscriptomic control.","authors":"José R Sotelo-Silveira","doi":"10.1016/j.tins.2025.09.005","DOIUrl":"https://doi.org/10.1016/j.tins.2025.09.005","url":null,"abstract":"<p><p>In a recent publication, Broix, Roy, and colleagues have shown that m<sup>6</sup>A controls local translation of the RNA-binding protein APC via YTHDF1, coupling RNA modification to β-actin mRNA local translation and axon growth. In addition, autism- and schizophrenia-associated METTL14 variants weaken YTHDF1-APC binding, reduce APC, and shorten axons, underscoring their involvement in neurodevelopmental disorders.</p>","PeriodicalId":23325,"journal":{"name":"Trends in Neurosciences","volume":" ","pages":""},"PeriodicalIF":15.1,"publicationDate":"2025-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145207743","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
How do ramping dynamics influence computations in the entorhinal cortex? 斜坡动力学如何影响内嗅皮层的计算？
IF 15.1 1区 医学
Trends in Neurosciences Pub Date : 2025-09-22 DOI: 10.1016/j.tins.2025.08.005
Matthew F Nolan
{"title":"How do ramping dynamics influence computations in the entorhinal cortex?","authors":"Matthew F Nolan","doi":"10.1016/j.tins.2025.08.005","DOIUrl":"https://doi.org/10.1016/j.tins.2025.08.005","url":null,"abstract":"<p><p>The entorhinal cortex is crucial for declarative memory and spatial cognition. Recent experiments reveal that many entorhinal neurons represent information through ramping activity in which their firing rate changes monotonically between behaviourally relevant boundaries. This Opinion considers the implications of entorhinal ramping dynamics for computations within the hippocampal formation. Localised firing of extensively investigated grid, border, and object cells is suited to categorisation and rapid learning, whereas ramping activity may reflect compressed codes for communication between areas, or entorhinal computations suited to generalisation. Thus, ramping dynamics may be a manifestation of fundamental but largely overlooked mechanisms contributing to memory and spatial cognition, suggesting a need to re-evaluate models of hippocampal-entorhinal function centred exclusively on sparse, localised codes.</p>","PeriodicalId":23325,"journal":{"name":"Trends in Neurosciences","volume":" ","pages":""},"PeriodicalIF":15.1,"publicationDate":"2025-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145132041","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Brain-body states as a link between cardiovascular and mental health. 脑-体状态是心血管和心理健康之间的联系。
IF 15.1 1区 医学
Trends in Neurosciences Pub Date : 2025-09-19 DOI: 10.1016/j.tins.2025.08.004
Arno Villringer, Vadim V Nikulin, Michael Gaebler
{"title":"Brain-body states as a link between cardiovascular and mental health.","authors":"Arno Villringer, Vadim V Nikulin, Michael Gaebler","doi":"10.1016/j.tins.2025.08.004","DOIUrl":"https://doi.org/10.1016/j.tins.2025.08.004","url":null,"abstract":"<p><p>Numerous studies in humans have demonstrated a strong link between heart and brain function at different timescales. We conceptualize this functional coupling using different dimensions of brain-body states, formed through the integration of the central and peripheral nervous systems (PNS and CNS, respectively). Using concepts from dynamical systems theory, we discuss how patterns of brain-body dimensions traverse a state space. Attractors signify stable configurations, which we categorize as micro-, meso-, or macro-states according to their duration and reversibility. These reflect different underlying mechanisms, such as neural interactions, hormonal signaling, and structural plasticity. Longer-lasting states restrict the space of possible (shorter-term) brain-body states underlying the mutual dependence of cardiovascular and brain function over the lifespan and in the development of diseases such as hypertension and depression. These considerations, which can be further generalized to include immunological and metabolic dimensions of brain-body states, have broad conceptual and clinical implications.</p>","PeriodicalId":23325,"journal":{"name":"Trends in Neurosciences","volume":" ","pages":""},"PeriodicalIF":15.1,"publicationDate":"2025-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145103087","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Sensory signals for nausea. 恶心的感觉信号。
IF 15.1 1区 医学
Trends in Neurosciences Pub Date : 2025-09-18 DOI: 10.1016/j.tins.2025.08.003
Shiling Hu, Ashley Loureiro, Chuchu Zhang
{"title":"Sensory signals for nausea.","authors":"Shiling Hu, Ashley Loureiro, Chuchu Zhang","doi":"10.1016/j.tins.2025.08.003","DOIUrl":"10.1016/j.tins.2025.08.003","url":null,"abstract":"<p><p>Nausea serves as a protective response against harmful ingested stimuli but can also be experienced as a discomforting aspect of various conditions. Recent insights have emerged regarding neural pathways and molecular mechanisms linked to this sensation. This often involves complex interactions of interoceptive neural pathways with the digestive, endocrine, and immune systems. This review summarizes recent findings using non-emetic (e.g., rodents) and emetic (e.g., ferrets, shrews, dogs) mammalian models to explore the molecular mechanisms of nausea, particularly in understudied malaise states. By investigating how nausea is triggered across different contexts, we aim to clarify the general sensory principles governing this response and to promote a shift in therapeutic research - from a top-down, observational paradigm to a bottom-up, mechanism-driven approach.</p>","PeriodicalId":23325,"journal":{"name":"Trends in Neurosciences","volume":" ","pages":""},"PeriodicalIF":15.1,"publicationDate":"2025-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12506644/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145092602","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Stomach-brain synchronisation is associated with poorer mental health. 胃脑同步与较差的心理健康有关。
IF 15.1 1区 医学
Trends in Neurosciences Pub Date : 2025-09-08 DOI: 10.1016/j.tins.2025.09.001
Edwin S Dalmaijer
{"title":"Stomach-brain synchronisation is associated with poorer mental health.","authors":"Edwin S Dalmaijer","doi":"10.1016/j.tins.2025.09.001","DOIUrl":"https://doi.org/10.1016/j.tins.2025.09.001","url":null,"abstract":"<p><p>In common parlance, 'being in touch with your body' is often used positively. However, in a recent study, Banellis, Rebollo, and colleagues show that better stomach-brain synchronisation is actually associated with increased anxiety and depression scores. These findings add an interesting dimension to debates on the role of interoception in mental health.</p>","PeriodicalId":23325,"journal":{"name":"Trends in Neurosciences","volume":" ","pages":""},"PeriodicalIF":15.1,"publicationDate":"2025-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145030646","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The integrated stress response in the brain: cell type-specific functions in health and neurological disorders. 大脑中的综合应激反应：健康和神经系统疾病中的细胞类型特异性功能。
IF 15.1 1区 医学
Trends in Neurosciences Pub Date : 2025-09-02 DOI: 10.1016/j.tins.2025.08.002
David Ho-Tieng, Vijendra Sharma, Nahum Sonenberg, Christos G Gkogkas, Arkady Khoutorsky
{"title":"The integrated stress response in the brain: cell type-specific functions in health and neurological disorders.","authors":"David Ho-Tieng, Vijendra Sharma, Nahum Sonenberg, Christos G Gkogkas, Arkady Khoutorsky","doi":"10.1016/j.tins.2025.08.002","DOIUrl":"https://doi.org/10.1016/j.tins.2025.08.002","url":null,"abstract":"<p><p>The integrated stress response (ISR) is an evolutionarily conserved signaling network that regulates protein synthesis in response to diverse cellular stressors to promote stress adaptation. The ISR also responds to physiological stimuli to modify the cellular proteome in an activity-dependent manner. Many common brain pathologies, including neurodegenerative and neurodevelopmental disorders, induce chronic cellular stress and subsequent ISR activation, which substantially contributes to disease progression. Importantly, various brain cell types exhibit disparate levels of sensitivity to cellular stress and differ in how the activation of the ISR influences their physiology. In this review, we highlight cell type-specific roles of the ISR in brain health and disease. We also discuss how therapeutically targeting the ISR in pathological states should account for the cell types being affected.</p>","PeriodicalId":23325,"journal":{"name":"Trends in Neurosciences","volume":" ","pages":""},"PeriodicalIF":15.1,"publicationDate":"2025-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144993582","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Long-lived cellular molecules in the brain. 大脑中长寿的细胞分子。
IF 15.1 1区 医学
Trends in Neurosciences Pub Date : 2025-09-01 Epub Date: 2025-07-30 DOI: 10.1016/j.tins.2025.07.004
Martin W Hetzer, Tomohisa Toda
{"title":"Long-lived cellular molecules in the brain.","authors":"Martin W Hetzer, Tomohisa Toda","doi":"10.1016/j.tins.2025.07.004","DOIUrl":"10.1016/j.tins.2025.07.004","url":null,"abstract":"<p><p>In long-lived mammals, including humans, brain cell homeostasis is critical for maintaining brain function throughout life. Most neurons are generated during development and must maintain their cellular identity and plasticity to preserve brain function. Although extensive studies indicate the importance of recycling and regenerating cellular molecules to maintain cellular homeostasis, recent evidence has shown that some proteins and RNAs do not turn over for months and even years. We propose that these long-lived cellular molecules may be the basis for maintaining brain function in the long term, but also a potential convergent target of brain aging. We highlight key discoveries and challenges, and propose potential directions to unravel the mystery of brain cell longevity.</p>","PeriodicalId":23325,"journal":{"name":"Trends in Neurosciences","volume":" ","pages":"645-654"},"PeriodicalIF":15.1,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144761460","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Shingles vaccination and neuroimmune vulnerability. 带状疱疹疫苗接种和神经免疫脆弱性。
IF 15.1 1区 医学
Trends in Neurosciences Pub Date : 2025-09-01 Epub Date: 2025-07-25 DOI: 10.1016/j.tins.2025.07.003
Xin Huang, Ben J Gu
{"title":"Shingles vaccination and neuroimmune vulnerability.","authors":"Xin Huang, Ben J Gu","doi":"10.1016/j.tins.2025.07.003","DOIUrl":"10.1016/j.tins.2025.07.003","url":null,"abstract":"<p><p>Recent studies report reduced dementia risk following shingles vaccination, suggesting that varicella-zoster virus (VZV) latency contributes to neuroimmune vulnerability. We propose that subclinical VZV reactivation acts as a renewable peripheral immune stressor, amplifying microglial priming in aging brains. Shingles vaccination may suppress this viral reservoir, reducing cumulative inflammatory tone. In this opinion article we contrast this mechanism with trained immunity and highlight how pathogen-specific and systemic effects may converge. Finally, we discuss the role of innate phagocytosis and resolution, suggesting that impaired clearance, rather than activation alone, sustains neuroinflammatory risk. Vaccination may thus modulate innate responsiveness and preserve neuroimmune balance in later life.</p>","PeriodicalId":23325,"journal":{"name":"Trends in Neurosciences","volume":" ","pages":"655-662"},"PeriodicalIF":15.1,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144718745","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Shaping the synapse through neuronal activity-regulated miRNAs. 通过神经元活动调节的mirna塑造突触。
IF 15.1 1区 医学
Trends in Neurosciences Pub Date : 2025-09-01 Epub Date: 2025-07-11 DOI: 10.1016/j.tins.2025.06.001
Raul Portugal, Beatriz Rodrigues, Ricardo A Leitão, Mariline Silva, Paulo S Pinheiro, Ana Luisa Carvalho
{"title":"Shaping the synapse through neuronal activity-regulated miRNAs.","authors":"Raul Portugal, Beatriz Rodrigues, Ricardo A Leitão, Mariline Silva, Paulo S Pinheiro, Ana Luisa Carvalho","doi":"10.1016/j.tins.2025.06.001","DOIUrl":"10.1016/j.tins.2025.06.001","url":null,"abstract":"<p><p>The brain's ability to adapt and support learning relies on experience-dependent synaptic plasticity, where connections between neurons are strengthened or weakened in response to activity. Recent research in mammalian systems reveals microRNAs (miRNAs) as crucial regulators of this process, offering a new perspective on how neurons achieve timely, localized control of protein synthesis. Neuronal activity influences every stage of the miRNA life cycle, from transcription to transport, maturation, and decay. Transcriptional regulation enables neuron-wide structural adaptations, while synapse-specific transport and maturation ensure localized protein synthesis. Though incompletely understood, activity-regulated miRNA decay allows for reversible modulation of gene expression. These discoveries highlight miRNAs as an essential layer of regulation, bridging neuronal activity with molecular changes that support learning and memory.</p>","PeriodicalId":23325,"journal":{"name":"Trends in Neurosciences","volume":" ","pages":"679-690"},"PeriodicalIF":15.1,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144620662","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Reconstructing Alzheimer's disease one cell type at a time using in vitro tricultures. 利用体外培养一次重建一种细胞类型的阿尔茨海默病。
IF 15.1 1区 医学
Trends in Neurosciences Pub Date : 2025-09-01 Epub Date: 2025-07-29 DOI: 10.1016/j.tins.2025.07.010
Tatiana A Giovannucci, Charles Arber, Selina Wray
{"title":"Reconstructing Alzheimer's disease one cell type at a time using in vitro tricultures.","authors":"Tatiana A Giovannucci, Charles Arber, Selina Wray","doi":"10.1016/j.tins.2025.07.010","DOIUrl":"10.1016/j.tins.2025.07.010","url":null,"abstract":"<p><p>In a recent study, Lish and colleagues used a fully human-based, induced pluripotent stem cell (iPSC)-derived triculture model of neurons, astrocytes, and microglia to delineate non-cell autonomous contributions to familial Alzheimer's disease (AD). This approach offers a versatile platform to explore early disease mechanisms, dissect cell-cell interactions, and support the development of targeted therapeutic or biomarker strategies.</p>","PeriodicalId":23325,"journal":{"name":"Trends in Neurosciences","volume":" ","pages":"643-644"},"PeriodicalIF":15.1,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144754403","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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