Local translation under epitranscriptomic control.

IF 15.1 1区医学 Q1 NEUROSCIENCES

Trends in Neurosciences Pub Date : 2025-09-30 DOI:10.1016/j.tins.2025.09.005

José R Sotelo-Silveira

引用次数: 0

Abstract

In a recent publication, Broix, Roy, and colleagues have shown that m⁶A controls local translation of the RNA-binding protein APC via YTHDF1, coupling RNA modification to β-actin mRNA local translation and axon growth. In addition, autism- and schizophrenia-associated METTL14 variants weaken YTHDF1-APC binding, reduce APC, and shorten axons, underscoring their involvement in neurodevelopmental disorders.

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表转录组控制下的局部翻译。

在最近发表的一篇文章中，Broix、Roy和同事们表明m6A通过YTHDF1控制RNA结合蛋白APC的局部翻译，将RNA修饰与β-actin mRNA的局部翻译和轴突生长结合起来。此外，自闭症和精神分裂症相关的METTL14变异体削弱YTHDF1-APC结合，减少APC，缩短轴突，强调它们参与神经发育障碍。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Trends in Neurosciences 医学-神经科学

CiteScore

26.50

自引率

1.30%

发文量

123

审稿时长

6-12 weeks

期刊介绍： For over four decades, Trends in Neurosciences (TINS) has been a prominent source of inspiring reviews and commentaries across all disciplines of neuroscience. TINS is a monthly, peer-reviewed journal, and its articles are curated by the Editor and authored by leading researchers in their respective fields. The journal communicates exciting advances in brain research, serves as a voice for the global neuroscience community, and highlights the contribution of neuroscientific research to medicine and society.