{"title":"Sensory signals for nausea.","authors":"Shiling Hu, Ashley Loureiro, Chuchu Zhang","doi":"10.1016/j.tins.2025.08.003","DOIUrl":null,"url":null,"abstract":"<p><p>Nausea serves as a protective response against harmful ingested stimuli but can also be experienced as a discomforting aspect of various conditions. Recent insights have emerged regarding neural pathways and molecular mechanisms linked to this sensation. This often involves complex interactions of interoceptive neural pathways with the digestive, endocrine, and immune systems. This review summarizes recent findings using non-emetic (e.g., rodents) and emetic (e.g., ferrets, shrews, dogs) mammalian models to explore the molecular mechanisms of nausea, particularly in understudied malaise states. By investigating how nausea is triggered across different contexts, we aim to clarify the general sensory principles governing this response and to promote a shift in therapeutic research - from a top-down, observational paradigm to a bottom-up, mechanism-driven approach.</p>","PeriodicalId":23325,"journal":{"name":"Trends in Neurosciences","volume":" ","pages":""},"PeriodicalIF":15.1000,"publicationDate":"2025-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12506644/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Trends in Neurosciences","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1016/j.tins.2025.08.003","RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"NEUROSCIENCES","Score":null,"Total":0}
引用次数: 0
Abstract
Nausea serves as a protective response against harmful ingested stimuli but can also be experienced as a discomforting aspect of various conditions. Recent insights have emerged regarding neural pathways and molecular mechanisms linked to this sensation. This often involves complex interactions of interoceptive neural pathways with the digestive, endocrine, and immune systems. This review summarizes recent findings using non-emetic (e.g., rodents) and emetic (e.g., ferrets, shrews, dogs) mammalian models to explore the molecular mechanisms of nausea, particularly in understudied malaise states. By investigating how nausea is triggered across different contexts, we aim to clarify the general sensory principles governing this response and to promote a shift in therapeutic research - from a top-down, observational paradigm to a bottom-up, mechanism-driven approach.
期刊介绍：
For over four decades, Trends in Neurosciences (TINS) has been a prominent source of inspiring reviews and commentaries across all disciplines of neuroscience. TINS is a monthly, peer-reviewed journal, and its articles are curated by the Editor and authored by leading researchers in their respective fields. The journal communicates exciting advances in brain research, serves as a voice for the global neuroscience community, and highlights the contribution of neuroscientific research to medicine and society.
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