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Putting the brakes on axonal branching. 为轴突分支踩刹车
IF 15.9 1区 医学
Trends in Neurosciences Pub Date : 2024-05-16 DOI: 10.1016/j.tins.2024.05.001
Ismael Ferrer, Chadni Sanyal, Marie-Jo Moutin, Damaris N Lorenzo
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引用次数: 0
The ‘in’s and out’s’ of descending pain modulation from the rostral ventromedial medulla 喙腹内侧延髓降序疼痛调节的 "进与退
IF 15.9 1区 医学
Trends in Neurosciences Pub Date : 2024-05-14 DOI: 10.1016/j.tins.2024.04.006
Caitlynn C. De Preter, Mary M. Heinricher
{"title":"The ‘in’s and out’s’ of descending pain modulation from the rostral ventromedial medulla","authors":"Caitlynn C. De Preter, Mary M. Heinricher","doi":"10.1016/j.tins.2024.04.006","DOIUrl":"https://doi.org/10.1016/j.tins.2024.04.006","url":null,"abstract":"<p>The descending-pain modulating circuit controls the experience of pain by modulating transmission of sensory signals through the dorsal horn. This circuit’s key output node, the rostral ventromedial medulla (RVM), integrates ‘top-down’ and ‘bottom-up’ inputs that regulate functionally defined RVM cell types, ‘OFF-cells’ and ‘ON-cells’, which respectively suppress or facilitate pain-related sensory processing. While recent advances have sought molecular definition of RVM cell types, conflicting behavioral findings highlight challenges involved in aligning functional and molecularly defined types. This review summarizes current understanding, derived primarily from rodent studies but with corroborating evidence from human imaging, of the role of RVM populations in pain modulation and persistent pain states and explores recent advances outlining inputs to, and outputs from, RVM pain-modulating neurons.</p>","PeriodicalId":23325,"journal":{"name":"Trends in Neurosciences","volume":"43 1","pages":""},"PeriodicalIF":15.9,"publicationDate":"2024-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140932541","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Advisory Board and Contents 咨询委员会和内容
IF 15.9 1区 医学
Trends in Neurosciences Pub Date : 2024-05-14 DOI: 10.1016/s0166-2236(24)00068-7
{"title":"Advisory Board and Contents","authors":"","doi":"10.1016/s0166-2236(24)00068-7","DOIUrl":"https://doi.org/10.1016/s0166-2236(24)00068-7","url":null,"abstract":"No Abstract","PeriodicalId":23325,"journal":{"name":"Trends in Neurosciences","volume":"38 1","pages":""},"PeriodicalIF":15.9,"publicationDate":"2024-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140932117","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Subscription and Copyright Information 订阅和版权信息
IF 15.9 1区 医学
Trends in Neurosciences Pub Date : 2024-05-14 DOI: 10.1016/s0166-2236(24)00071-7
{"title":"Subscription and Copyright Information","authors":"","doi":"10.1016/s0166-2236(24)00071-7","DOIUrl":"https://doi.org/10.1016/s0166-2236(24)00071-7","url":null,"abstract":"No Abstract","PeriodicalId":23325,"journal":{"name":"Trends in Neurosciences","volume":"66 1","pages":""},"PeriodicalIF":15.9,"publicationDate":"2024-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140932466","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Neurobiological basis of emergence from anesthesia. 麻醉苏醒的神经生物学基础。
IF 15.9 1区 医学
Trends in Neurosciences Pub Date : 2024-05-01 Epub Date: 2024-03-14 DOI: 10.1016/j.tins.2024.02.006
Xue-Jun Song, Jiang-Jian Hu
{"title":"Neurobiological basis of emergence from anesthesia.","authors":"Xue-Jun Song, Jiang-Jian Hu","doi":"10.1016/j.tins.2024.02.006","DOIUrl":"10.1016/j.tins.2024.02.006","url":null,"abstract":"<p><p>The suppression of consciousness by anesthetics and the emergence of the brain from anesthesia are complex and elusive processes. Anesthetics may exert their inhibitory effects by binding to specific protein targets or through membrane-mediated targets, disrupting neural activity and the integrity and function of neural circuits responsible for signal transmission and conscious perception/subjective experience. Emergence from anesthesia was generally thought to depend on the elimination of the anesthetic from the body. Recently, studies have suggested that emergence from anesthesia is a dynamic and active process that can be partially controlled and is independent of the specific molecular targets of anesthetics. This article summarizes the fundamentals of anesthetics' actions in the brain and the mechanisms of emergence from anesthesia that have been recently revealed in animal studies.</p>","PeriodicalId":23325,"journal":{"name":"Trends in Neurosciences","volume":" ","pages":"355-366"},"PeriodicalIF":15.9,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140137276","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
CRISPR-based identification of N-terminal acetylation in synucleinopathies. 基于 CRISPR 的突触核蛋白病 N 端乙酰化鉴定。
IF 15.9 1区 医学
Trends in Neurosciences Pub Date : 2024-05-01 Epub Date: 2024-03-28 DOI: 10.1016/j.tins.2024.03.006
Eun-Jin Bae, Seung-Jae Lee
{"title":"CRISPR-based identification of N-terminal acetylation in synucleinopathies.","authors":"Eun-Jin Bae, Seung-Jae Lee","doi":"10.1016/j.tins.2024.03.006","DOIUrl":"10.1016/j.tins.2024.03.006","url":null,"abstract":"<p><p>A recent study by Kumar et al. identified several biological pathways that regulate the levels of endogenous alpha-synuclein (α-synuclein). They specifically highlighted the N-terminal acetylation (NTA) pathway as an important factor in maintaining the stability of endogenous α-synuclein, suggesting targeting the NTA pathway as a potential therapeutic approach.</p>","PeriodicalId":23325,"journal":{"name":"Trends in Neurosciences","volume":" ","pages":"324-325"},"PeriodicalIF":15.9,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140327202","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Orchestrating neuronal activity-dependent translation via the integrated stress response protein GADD34 通过综合应激反应蛋白 GADD34 协调神经元活动依赖性翻译
IF 15.9 1区 医学
Trends in Neurosciences Pub Date : 2024-04-13 DOI: 10.1016/j.tins.2024.03.008
{"title":"Orchestrating neuronal activity-dependent translation via the integrated stress response protein GADD34","authors":"","doi":"10.1016/j.tins.2024.03.008","DOIUrl":"https://doi.org/10.1016/j.tins.2024.03.008","url":null,"abstract":"Abstract not available","PeriodicalId":23325,"journal":{"name":"Trends in Neurosciences","volume":"94 1","pages":""},"PeriodicalIF":15.9,"publicationDate":"2024-04-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140626155","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Advances in animal models of prenatal opioid exposure 产前阿片类药物暴露动物模型的研究进展
IF 15.9 1区 医学
Trends in Neurosciences Pub Date : 2024-04-12 DOI: 10.1016/j.tins.2024.03.005
Julia R. Ferrante, Julie A. Blendy
{"title":"Advances in animal models of prenatal opioid exposure","authors":"Julia R. Ferrante, Julie A. Blendy","doi":"10.1016/j.tins.2024.03.005","DOIUrl":"https://doi.org/10.1016/j.tins.2024.03.005","url":null,"abstract":"<p>Neonatal opioid withdrawal syndrome (NOWS) is a growing public health concern. The complexity of <em>in utero</em> opioid exposure in clinical studies makes it difficult to investigate underlying mechanisms that could ultimately inform early diagnosis and treatments. Clinical studies are unable to dissociate the influence of maternal polypharmacy or the environment from direct effects of <em>in utero</em> opioid exposure, highlighting the need for effective animal models. Early animal models of prenatal opioid exposure primarily used the prototypical opioid, morphine, and opioid exposure that was often limited to a narrow period during gestation. In recent years, the number of preclinical studies has grown rapidly. Newer models utilize both prescription and nonprescription opioids and vary the onset and duration of opioid exposure. In this review, we summarize novel prenatal opioid exposure models developed in recent years and attempt to reconcile results between studies while critically identifying gaps within the current literature.</p>","PeriodicalId":23325,"journal":{"name":"Trends in Neurosciences","volume":"21 1","pages":""},"PeriodicalIF":15.9,"publicationDate":"2024-04-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140626021","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Advisory Board and Contents 咨询委员会和内容
IF 15.9 1区 医学
Trends in Neurosciences Pub Date : 2024-04-09 DOI: 10.1016/s0166-2236(24)00046-8
{"title":"Advisory Board and Contents","authors":"","doi":"10.1016/s0166-2236(24)00046-8","DOIUrl":"https://doi.org/10.1016/s0166-2236(24)00046-8","url":null,"abstract":"Abstract not available","PeriodicalId":23325,"journal":{"name":"Trends in Neurosciences","volume":"6 1","pages":""},"PeriodicalIF":15.9,"publicationDate":"2024-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140626028","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Subscription and Copyright Information 订阅和版权信息
IF 15.9 1区 医学
Trends in Neurosciences Pub Date : 2024-04-09 DOI: 10.1016/s0166-2236(24)00049-3
{"title":"Subscription and Copyright Information","authors":"","doi":"10.1016/s0166-2236(24)00049-3","DOIUrl":"https://doi.org/10.1016/s0166-2236(24)00049-3","url":null,"abstract":"Abstract not available","PeriodicalId":23325,"journal":{"name":"Trends in Neurosciences","volume":"54 1","pages":""},"PeriodicalIF":15.9,"publicationDate":"2024-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140626151","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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