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Astrocytes in selective vulnerability to neurodegenerative disease. 选择性易患神经退行性疾病的星形胶质细胞
IF 15.9 1区 医学
Trends in Neurosciences Pub Date : 2024-04-01 Epub Date: 2024-03-22 DOI: 10.1016/j.tins.2024.02.008
Till S Zimmer, Adam L Orr, Anna G Orr
{"title":"Astrocytes in selective vulnerability to neurodegenerative disease.","authors":"Till S Zimmer, Adam L Orr, Anna G Orr","doi":"10.1016/j.tins.2024.02.008","DOIUrl":"10.1016/j.tins.2024.02.008","url":null,"abstract":"<p><p>Selective vulnerability of specific brain regions and cell populations is a hallmark of neurodegenerative disorders. Mechanisms of selective vulnerability involve neuronal heterogeneity, functional specializations, and differential sensitivities to stressors and pathogenic factors. In this review we discuss the growing body of literature suggesting that, like neurons, astrocytes are heterogeneous and specialized, respond to and integrate diverse inputs, and induce selective effects on brain function. In disease, astrocytes undergo specific, context-dependent changes that promote different pathogenic trajectories and functional outcomes. We propose that astrocytes contribute to selective vulnerability through maladaptive transitions to context-divergent phenotypes that impair specific brain regions and functions. Further studies on the multifaceted roles of astrocytes in disease may provide new therapeutic approaches to enhance resilience against neurodegenerative disorders.</p>","PeriodicalId":23325,"journal":{"name":"Trends in Neurosciences","volume":" ","pages":"289-302"},"PeriodicalIF":15.9,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11006581/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140194660","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Supermultipotency and unpredictability in the developing superior colliculus. 发育中上丘的超多重性和不可预测性
IF 15.9 1区 医学
Trends in Neurosciences Pub Date : 2024-04-01 Epub Date: 2024-03-20 DOI: 10.1016/j.tins.2024.03.001
Andrii Rudenko, In-Jung Kim
{"title":"Supermultipotency and unpredictability in the developing superior colliculus.","authors":"Andrii Rudenko, In-Jung Kim","doi":"10.1016/j.tins.2024.03.001","DOIUrl":"10.1016/j.tins.2024.03.001","url":null,"abstract":"<p><p>A recent study by Cheung, Pauler, Koppensteiner et al. combining lineage tracing with single-cell RNA sequencing (scRNA-seq) has revealed unexpected features of the developing superior colliculus (SC). Extremely multipotent individual progenitors generate all types of SC neurons and glial cells that were found to localize in a non-predetermined pattern, demonstrating a remarkable degree of unpredictability in SC development.</p>","PeriodicalId":23325,"journal":{"name":"Trends in Neurosciences","volume":" ","pages":"239-240"},"PeriodicalIF":15.9,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11047761/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140185661","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The 'middle-aging' brain. 中年 "大脑
IF 15.9 1区 医学
Trends in Neurosciences Pub Date : 2024-04-01 Epub Date: 2024-03-19 DOI: 10.1016/j.tins.2024.02.001
Sebastian Dohm-Hansen, Jane A English, Aonghus Lavelle, Carlos P Fitzsimons, Paul J Lucassen, Yvonne M Nolan
{"title":"The 'middle-aging' brain.","authors":"Sebastian Dohm-Hansen, Jane A English, Aonghus Lavelle, Carlos P Fitzsimons, Paul J Lucassen, Yvonne M Nolan","doi":"10.1016/j.tins.2024.02.001","DOIUrl":"10.1016/j.tins.2024.02.001","url":null,"abstract":"<p><p>Middle age has historically been an understudied period of life compared to older age, when cognitive and brain health decline are most pronounced, but the scope for intervention may be limited. However, recent research suggests that middle age could mark a shift in brain aging. We review emerging evidence on multiple levels of analysis indicating that midlife is a period defined by unique central and peripheral processes that shape future cognitive trajectories and brain health. Informed by recent developments in aging research and lifespan studies in humans and animal models, we highlight the utility of modeling non-linear changes in study samples with wide subject age ranges to distinguish life stage-specific processes from those acting linearly throughout the lifespan.</p>","PeriodicalId":23325,"journal":{"name":"Trends in Neurosciences","volume":" ","pages":"259-272"},"PeriodicalIF":15.9,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140176687","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Balancing neuronal activity to fight neurodevelopmental disorders. 平衡神经元活动，对抗神经发育障碍。
IF 15.9 1区 医学
Trends in Neurosciences Pub Date : 2024-04-01 Epub Date: 2024-03-22 DOI: 10.1016/j.tins.2024.03.002
Stephanie Le, Carmen Menacho, Alessandro Prigione
{"title":"Balancing neuronal activity to fight neurodevelopmental disorders.","authors":"Stephanie Le, Carmen Menacho, Alessandro Prigione","doi":"10.1016/j.tins.2024.03.002","DOIUrl":"10.1016/j.tins.2024.03.002","url":null,"abstract":"<p><p>In a recent study, Rylaarsdam and colleagues revealed that mutant PACS1 gene, which causes a rare neurodevelopmental syndrome, affects the firing ability of human neurons without dysregulating the cellular architecture of brain organoids. These findings suggest aberrant neuronal electrophysiology as a possible interventional target for pediatric diseases impairing brain development.</p>","PeriodicalId":23325,"journal":{"name":"Trends in Neurosciences","volume":" ","pages":"241-242"},"PeriodicalIF":15.9,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140194661","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The selfish network: how the brain preserves behavioral function through shifts in neuronal network state. 自私的网络：大脑如何通过神经元网络状态的变化来保持行为功能。
IF 15.9 1区 医学
Trends in Neurosciences Pub Date : 2024-04-01 Epub Date: 2024-03-13 DOI: 10.1016/j.tins.2024.02.005
Albrecht Stroh, Susann Schweiger, Jan-Marino Ramirez, Oliver Tüscher
{"title":"The selfish network: how the brain preserves behavioral function through shifts in neuronal network state.","authors":"Albrecht Stroh, Susann Schweiger, Jan-Marino Ramirez, Oliver Tüscher","doi":"10.1016/j.tins.2024.02.005","DOIUrl":"10.1016/j.tins.2024.02.005","url":null,"abstract":"<p><p>Neuronal networks possess the ability to regulate their activity states in response to disruptions. How and when neuronal networks turn from physiological into pathological states, leading to the manifestation of neuropsychiatric disorders, remains largely unknown. Here, we propose that neuronal networks intrinsically maintain network stability even at the cost of neuronal loss. Despite the new stable state being potentially maladaptive, neural networks may not reverse back to states associated with better long-term outcomes. These maladaptive states are often associated with hyperactive neurons, marking the starting point for activity-dependent neurodegeneration. Transitions between network states may occur rapidly, and in discrete steps rather than continuously, particularly in neurodegenerative disorders. The self-stabilizing, metastable, and noncontinuous characteristics of these network states can be mathematically described as attractors. Maladaptive attractors may represent a distinct pathophysiological entity that could serve as a target for new therapies and for fostering resilience.</p>","PeriodicalId":23325,"journal":{"name":"Trends in Neurosciences","volume":" ","pages":"246-258"},"PeriodicalIF":15.9,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140132635","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Protein-protein interactions regulating α-synuclein pathology. 调节α-突触核蛋白病理学的蛋白质间相互作用
IF 15.9 1区 医学
Trends in Neurosciences Pub Date : 2024-03-01 Epub Date: 2024-02-13 DOI: 10.1016/j.tins.2024.01.002
Jiannan Wang, Lijun Dai, Sichun Chen, Zhaohui Zhang, Xin Fang, Zhentao Zhang
{"title":"Protein-protein interactions regulating α-synuclein pathology.","authors":"Jiannan Wang, Lijun Dai, Sichun Chen, Zhaohui Zhang, Xin Fang, Zhentao Zhang","doi":"10.1016/j.tins.2024.01.002","DOIUrl":"10.1016/j.tins.2024.01.002","url":null,"abstract":"<p><p>Parkinson's disease (PD) is a neurodegenerative disease characterized by the degeneration of dopaminergic neurons in the substantia nigra pars compacta (SNpc) and the formation of Lewy bodies (LBs). The main proteinaceous component of LBs is aggregated α-synuclein (α-syn). However, the mechanisms underlying α-syn aggregation are not yet fully understood. Converging lines of evidence indicate that, under certain pathological conditions, various proteins can interact with α-syn and regulate its aggregation. Understanding these protein-protein interactions is crucial for unraveling the molecular mechanisms contributing to PD pathogenesis. In this review we provide an overview of the current knowledge on protein-protein interactions that regulate α-syn aggregation. Additionally, we briefly summarize the methods used to investigate the influence of protein-protein interactions on α-syn aggregation and propagation.</p>","PeriodicalId":23325,"journal":{"name":"Trends in Neurosciences","volume":" ","pages":"209-226"},"PeriodicalIF":15.9,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139736217","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A noncoding role of coding mRNA in monogenic olfactory receptor choice. 编码 mRNA 在单基因嗅觉受体选择中的非编码作用
IF 15.9 1区 医学
Trends in Neurosciences Pub Date : 2024-03-01 Epub Date: 2024-02-19 DOI: 10.1016/j.tins.2024.02.004
Yue Hao, Kang-Ying Qian, Qian Li
{"title":"A noncoding role of coding mRNA in monogenic olfactory receptor choice.","authors":"Yue Hao, Kang-Ying Qian, Qian Li","doi":"10.1016/j.tins.2024.02.004","DOIUrl":"10.1016/j.tins.2024.02.004","url":null,"abstract":"<p><p>In a recent study, Pourmorady and colleagues uncovered a noncoding role for olfactory receptor (OR)-coding mRNA in mediating nuclear architecture and singular OR choice. The OR mRNAs reinforce the prevailing enhancer hub and inhibit other competitors, facilitating transition from polygenic to singular OR expression.</p>","PeriodicalId":23325,"journal":{"name":"Trends in Neurosciences","volume":" ","pages":"167-169"},"PeriodicalIF":15.9,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139913574","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Overarching pathomechanisms in inherited peripheral neuropathies, spastic paraplegias, and cerebellar ataxias. 遗传性周围神经病、痉挛性截瘫和小脑性共济失调的总体病理机制。
IF 15.9 1区 医学
Trends in Neurosciences Pub Date : 2024-03-01 Epub Date: 2024-02-14 DOI: 10.1016/j.tins.2024.01.004
Liedewei Van de Vondel, Jonathan De Winter, Vincent Timmerman, Jonathan Baets
{"title":"Overarching pathomechanisms in inherited peripheral neuropathies, spastic paraplegias, and cerebellar ataxias.","authors":"Liedewei Van de Vondel, Jonathan De Winter, Vincent Timmerman, Jonathan Baets","doi":"10.1016/j.tins.2024.01.004","DOIUrl":"10.1016/j.tins.2024.01.004","url":null,"abstract":"<p><p>International consortia collaborating on the genetics of rare diseases have significantly boosted our understanding of inherited neurological disorders. Historical clinical classification boundaries were drawn between disorders with seemingly different etiologies, such as inherited peripheral neuropathies (IPNs), spastic paraplegias, and cerebellar ataxias. These clinically defined borders are being challenged by the identification of mutations in genes displaying wide phenotypic spectra and by shared pathomechanistic themes, which are valuable indications for therapy development. We highlight common cellular alterations that underlie this genetic landscape, including alteration of cytoskeleton, axonal transport, mitochondrial function, and DNA repair response. Finally, we discuss venues for future research using the long axonopathies of the PNS as a model to explore other neurogenetic disorders.</p>","PeriodicalId":23325,"journal":{"name":"Trends in Neurosciences","volume":" ","pages":"227-238"},"PeriodicalIF":15.9,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139742111","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Advisory Board and Contents 咨询委员会和内容
IF 15.9 1区 医学
Trends in Neurosciences Pub Date : 2024-02-13 DOI: 10.1016/s0166-2236(24)00004-3
{"title":"Advisory Board and Contents","authors":"","doi":"10.1016/s0166-2236(24)00004-3","DOIUrl":"https://doi.org/10.1016/s0166-2236(24)00004-3","url":null,"abstract":"","PeriodicalId":23325,"journal":{"name":"Trends in Neurosciences","volume":"2 1","pages":""},"PeriodicalIF":15.9,"publicationDate":"2024-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139924270","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Subscription and Copyright Information 订阅和版权信息
IF 15.9 1区 医学
Trends in Neurosciences Pub Date : 2024-02-13 DOI: 10.1016/s0166-2236(24)00007-9
{"title":"Subscription and Copyright Information","authors":"","doi":"10.1016/s0166-2236(24)00007-9","DOIUrl":"https://doi.org/10.1016/s0166-2236(24)00007-9","url":null,"abstract":"","PeriodicalId":23325,"journal":{"name":"Trends in Neurosciences","volume":"34 1","pages":""},"PeriodicalIF":15.9,"publicationDate":"2024-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139924253","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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