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Overarching pathomechanisms in inherited peripheral neuropathies, spastic paraplegias, and cerebellar ataxias. 遗传性周围神经病、痉挛性截瘫和小脑性共济失调的总体病理机制。
IF 15.9 1区 医学
Trends in Neurosciences Pub Date : 2024-03-01 Epub Date: 2024-02-14 DOI: 10.1016/j.tins.2024.01.004
Liedewei Van de Vondel, Jonathan De Winter, Vincent Timmerman, Jonathan Baets
{"title":"Overarching pathomechanisms in inherited peripheral neuropathies, spastic paraplegias, and cerebellar ataxias.","authors":"Liedewei Van de Vondel, Jonathan De Winter, Vincent Timmerman, Jonathan Baets","doi":"10.1016/j.tins.2024.01.004","DOIUrl":"10.1016/j.tins.2024.01.004","url":null,"abstract":"<p><p>International consortia collaborating on the genetics of rare diseases have significantly boosted our understanding of inherited neurological disorders. Historical clinical classification boundaries were drawn between disorders with seemingly different etiologies, such as inherited peripheral neuropathies (IPNs), spastic paraplegias, and cerebellar ataxias. These clinically defined borders are being challenged by the identification of mutations in genes displaying wide phenotypic spectra and by shared pathomechanistic themes, which are valuable indications for therapy development. We highlight common cellular alterations that underlie this genetic landscape, including alteration of cytoskeleton, axonal transport, mitochondrial function, and DNA repair response. Finally, we discuss venues for future research using the long axonopathies of the PNS as a model to explore other neurogenetic disorders.</p>","PeriodicalId":23325,"journal":{"name":"Trends in Neurosciences","volume":null,"pages":null},"PeriodicalIF":15.9,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139742111","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Advisory Board and Contents 咨询委员会和内容
IF 15.9 1区 医学
Trends in Neurosciences Pub Date : 2024-02-13 DOI: 10.1016/s0166-2236(24)00004-3
{"title":"Advisory Board and Contents","authors":"","doi":"10.1016/s0166-2236(24)00004-3","DOIUrl":"https://doi.org/10.1016/s0166-2236(24)00004-3","url":null,"abstract":"","PeriodicalId":23325,"journal":{"name":"Trends in Neurosciences","volume":null,"pages":null},"PeriodicalIF":15.9,"publicationDate":"2024-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139924270","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Subscription and Copyright Information 订阅和版权信息
IF 15.9 1区 医学
Trends in Neurosciences Pub Date : 2024-02-13 DOI: 10.1016/s0166-2236(24)00007-9
{"title":"Subscription and Copyright Information","authors":"","doi":"10.1016/s0166-2236(24)00007-9","DOIUrl":"https://doi.org/10.1016/s0166-2236(24)00007-9","url":null,"abstract":"","PeriodicalId":23325,"journal":{"name":"Trends in Neurosciences","volume":null,"pages":null},"PeriodicalIF":15.9,"publicationDate":"2024-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139924253","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Contiguity in perception: origins in cellular associative computations 感知中的连续性：细胞联想计算的起源
IF 15.9 1区 医学
Trends in Neurosciences Pub Date : 2024-02-02 DOI: 10.1016/j.tins.2024.01.001
Christian Hansel
{"title":"Contiguity in perception: origins in cellular associative computations","authors":"Christian Hansel","doi":"10.1016/j.tins.2024.01.001","DOIUrl":"https://doi.org/10.1016/j.tins.2024.01.001","url":null,"abstract":"<p>Our brains are good at detecting and learning associative structures; according to some linguistic theories, this capacity even constitutes a prerequisite for the development of syntax and compositionality in language and verbalized thought. I will argue that the search for associative motifs in input patterns is an evolutionary old brain function that enables contiguity in sensory perception and orientation in time and space. It has its origins in an elementary material property of cells that is particularly evident at chemical synapses: input-assigned calcium influx that activates calcium sensor proteins involved in memory storage. This machinery for the detection and learning of associative motifs generates knowledge about input relationships and integrates this knowledge into existing networks through updates in connectivity patterns.</p>","PeriodicalId":23325,"journal":{"name":"Trends in Neurosciences","volume":null,"pages":null},"PeriodicalIF":15.9,"publicationDate":"2024-02-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139678570","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
UndERACting ion channels in neurodegeneration. 神经退行性变中的欠作用离子通道。
IF 15.9 1区 医学
Trends in Neurosciences Pub Date : 2024-02-01 Epub Date: 2023-11-29 DOI: 10.1016/j.tins.2023.11.002
Matisse T Jacobs, Rebecca San Gil, Adam K Walker
{"title":"UndERACting ion channels in neurodegeneration.","authors":"Matisse T Jacobs, Rebecca San Gil, Adam K Walker","doi":"10.1016/j.tins.2023.11.002","DOIUrl":"10.1016/j.tins.2023.11.002","url":null,"abstract":"<p><p>In a recent study, Guo and colleagues characterised the function of an elusive endoplasmic reticulum (ER) anion channel protein, Chloride Channel CLiC Like 1 (CLCC1), and identified rare CLCC1 variants in people with amyotrophic lateral sclerosis (ALS). CLCC1 mutants disrupted ER function in vitro and promoted ALS-like pathology and neurodegeneration in mice. This work reveals a previously uncharacterised pathway involved in ER calcium release and highlights new pathogenic mechanisms underlying neurodegeneration.</p>","PeriodicalId":23325,"journal":{"name":"Trends in Neurosciences","volume":null,"pages":null},"PeriodicalIF":15.9,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138462827","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Identifying vagal sensory neurons driving the Bezold-Jarisch reflex. 识别驱动Bezold-Jarisch反射的迷走感觉神经元。
IF 15.9 1区 医学
Trends in Neurosciences Pub Date : 2024-02-01 Epub Date: 2023-11-29 DOI: 10.1016/j.tins.2023.11.007
Beth A Habecker
{"title":"Identifying vagal sensory neurons driving the Bezold-Jarisch reflex.","authors":"Beth A Habecker","doi":"10.1016/j.tins.2023.11.007","DOIUrl":"10.1016/j.tins.2023.11.007","url":null,"abstract":"<p><p>Homeostatic reflexes are crucial for life, but the subpopulations of sensory neurons that stimulate these reflexes are largely unknown. A recent paper from Lovelace, Ma, and colleagues identified a population of sensory neurons in the cardiac ventricle that underlies the Bezold-Jarisch reflex and triggers syncope (fainting).</p>","PeriodicalId":23325,"journal":{"name":"Trends in Neurosciences","volume":null,"pages":null},"PeriodicalIF":15.9,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10922441/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138462826","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Capturing postpandemic changes in research participants. 捕捉大流行后研究参与者的变化。
IF 15.9 1区 医学
Trends in Neurosciences Pub Date : 2024-02-01 Epub Date: 2023-11-10 DOI: 10.1016/j.tins.2023.10.005
Marian E Berryhill
{"title":"Capturing postpandemic changes in research participants.","authors":"Marian E Berryhill","doi":"10.1016/j.tins.2023.10.005","DOIUrl":"10.1016/j.tins.2023.10.005","url":null,"abstract":"<p><p>The impact of the COVID-19 pandemic on physical and mental health hardly need be reiterated. Yet, there are likely other indirect aftereffects of COVID-19 infection in addition to the direct effects. This article aims to initiate a conversation regarding difficult-to-capture outcomes of the pandemic that are relevant to researchers who test human participants. These considerations encourage collection of additional measures when assessing pre- versus postpandemic patterns of behavior.</p>","PeriodicalId":23325,"journal":{"name":"Trends in Neurosciences","volume":null,"pages":null},"PeriodicalIF":15.9,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89719700","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Tuning neural circuits and behaviors by microglia in the adult brain 小胶质细胞在成人大脑中调节神经回路和行为
IF 15.9 1区 医学
Trends in Neurosciences Pub Date : 2024-01-19 DOI: 10.1016/j.tins.2023.12.003
Shunyi Zhao, Anthony D. Umpierre, Long-Jun Wu
{"title":"Tuning neural circuits and behaviors by microglia in the adult brain","authors":"Shunyi Zhao, Anthony D. Umpierre, Long-Jun Wu","doi":"10.1016/j.tins.2023.12.003","DOIUrl":"https://doi.org/10.1016/j.tins.2023.12.003","url":null,"abstract":"<p>Microglia are the primary immune cells of the CNS, contributing to both inflammatory damage and tissue repair in neurological disorder. In addition, emerging evidence highlights the role of homeostatic microglia in regulating neuronal activity, interacting with synapses, tuning neural circuits, and modulating behaviors. Herein, we review how microglia sense and regulate neuronal activity through synaptic interactions, thereby directly engaging with neural networks and behaviors. We discuss current studies utilizing microglial optogenetic and chemogenetic approaches to modulate adult neural circuits. These manipulations of microglia across different CNS regions lead to diverse behavioral consequences. We propose that spatial heterogeneity of microglia–neuron interaction lays the groundwork for understanding diverse functions of microglia in neural circuits and behaviors.</p>","PeriodicalId":23325,"journal":{"name":"Trends in Neurosciences","volume":null,"pages":null},"PeriodicalIF":15.9,"publicationDate":"2024-01-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139508214","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
An integrative view on the cell-type-specific mechanisms of ketamine's antidepressant actions 关于氯胺酮抗抑郁作用的细胞类型特异性机制的综合观点
IF 15.9 1区 医学
Trends in Neurosciences Pub Date : 2024-01-13 DOI: 10.1016/j.tins.2023.12.004
Verne E. Lewis, G. Rurak, N. Salmaso, A. Aguilar-Valles
{"title":"An integrative view on the cell-type-specific mechanisms of ketamine's antidepressant actions","authors":"Verne E. Lewis, G. Rurak, N. Salmaso, A. Aguilar-Valles","doi":"10.1016/j.tins.2023.12.004","DOIUrl":"https://doi.org/10.1016/j.tins.2023.12.004","url":null,"abstract":"","PeriodicalId":23325,"journal":{"name":"Trends in Neurosciences","volume":null,"pages":null},"PeriodicalIF":15.9,"publicationDate":"2024-01-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139437169","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Latent-state and model-based learning in PTSD 创伤后应激障碍中的潜伏状态学习和基于模型的学习
IF 15.9 1区 医学
Trends in Neurosciences Pub Date : 2024-01-11 DOI: 10.1016/j.tins.2023.12.002
Josh M. Cisler, Joseph E. Dunsmoor, Gregory A. Fonzo, Charles B. Nemeroff
{"title":"Latent-state and model-based learning in PTSD","authors":"Josh M. Cisler, Joseph E. Dunsmoor, Gregory A. Fonzo, Charles B. Nemeroff","doi":"10.1016/j.tins.2023.12.002","DOIUrl":"https://doi.org/10.1016/j.tins.2023.12.002","url":null,"abstract":"<p>Post-traumatic stress disorder (PTSD) is characterized by altered emotional and behavioral responding following a traumatic event. In this article, we review the concepts of latent-state and model-based learning (i.e., learning and inferring abstract task representations) and discuss their relevance for clinical and neuroscience models of PTSD. Recent data demonstrate evidence for brain and behavioral biases in these learning processes in PTSD. These new data potentially recast excessive fear towards trauma cues as a problem in learning and updating abstract task representations, as opposed to traditional conceptualizations focused on stimulus-specific learning. Biases in latent-state and model-based learning may also be a common mechanism targeted in common therapies for PTSD. We highlight key knowledge gaps that need to be addressed to further elaborate how latent-state learning and its associated neurocircuitry mechanisms function in PTSD and how to optimize treatments to target these processes.</p>","PeriodicalId":23325,"journal":{"name":"Trends in Neurosciences","volume":null,"pages":null},"PeriodicalIF":15.9,"publicationDate":"2024-01-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139420878","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
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