Nandkishore Prakash, Ameair Abu Irqeba, Joshua G Corbin
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引用次数: 0
摘要
在所研究的脊椎动物中,内侧杏仁核(MeA)是向纹状体末端床核(BNST)和下丘脑等下游细胞核传递与社会和/或生存相关的感觉信息的中心枢纽。交配、攻击、养育子女和躲避捕食者等由 MeA 驱动的行为由不同的分子定义的抑制性和兴奋性神经元输出群处理。过去二十年的研究工作已经破解了多种 MeA 神经元是如何从胚胎发育过程中产生的,揭示了来自多个端脑和间脑祖细胞域的贡献。在此,我们首先简要概述了目前有关 MeA 在社会行为中的作用的研究结果,然后深入探讨了目前对这一复杂结构在发育过程中如何特定化的认识。我们概述了基于这些发现而形成的 MeA 概念模型。我们进一步推测,MeA 的胚胎发育程序如何为后来出现的支配硬线行为的定型电路提供信息。
Across studied vertebrates, the medial amygdala (MeA) is a central hub for relaying sensory information with social and/or survival relevance to downstream nuclei such as the bed nucleus of stria terminalis (BNST) and the hypothalamus. MeA-driven behaviors, such as mating, aggression, parenting, and predator avoidance are processed by different molecularly defined inhibitory and excitatory neuronal output populations. Work over the past two decades has deciphered how diverse MeA neurons arise from embryonic development, revealing contributions from multiple telencephalic and diencephalic progenitor domains. Here, we first provide a brief overview of current findings regarding the role of the MeA in social behaviors, followed by a deeper dive into current knowledge of how this complex structure is specified during development. We outline a conceptual model of MeA formation that has emerged based on these findings. We further postulate how embryonic developmental programming of the MeA may inform later emergence of stereotypical circuitry governing hardwired behaviors.
期刊介绍:
For over four decades, Trends in Neurosciences (TINS) has been a prominent source of inspiring reviews and commentaries across all disciplines of neuroscience. TINS is a monthly, peer-reviewed journal, and its articles are curated by the Editor and authored by leading researchers in their respective fields. The journal communicates exciting advances in brain research, serves as a voice for the global neuroscience community, and highlights the contribution of neuroscientific research to medicine and society.