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Orchestrating neuronal activity-dependent translation via the integrated stress response protein GADD34 通过综合应激反应蛋白 GADD34 协调神经元活动依赖性翻译
IF 15.9 1区 医学
Trends in Neurosciences Pub Date : 2024-04-13 DOI: 10.1016/j.tins.2024.03.008
{"title":"Orchestrating neuronal activity-dependent translation via the integrated stress response protein GADD34","authors":"","doi":"10.1016/j.tins.2024.03.008","DOIUrl":"https://doi.org/10.1016/j.tins.2024.03.008","url":null,"abstract":"Abstract not available","PeriodicalId":23325,"journal":{"name":"Trends in Neurosciences","volume":"94 1","pages":""},"PeriodicalIF":15.9,"publicationDate":"2024-04-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140626155","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Advances in animal models of prenatal opioid exposure 产前阿片类药物暴露动物模型的研究进展
IF 15.9 1区 医学
Trends in Neurosciences Pub Date : 2024-04-12 DOI: 10.1016/j.tins.2024.03.005
Julia R. Ferrante, Julie A. Blendy
{"title":"Advances in animal models of prenatal opioid exposure","authors":"Julia R. Ferrante, Julie A. Blendy","doi":"10.1016/j.tins.2024.03.005","DOIUrl":"https://doi.org/10.1016/j.tins.2024.03.005","url":null,"abstract":"<p>Neonatal opioid withdrawal syndrome (NOWS) is a growing public health concern. The complexity of <em>in utero</em> opioid exposure in clinical studies makes it difficult to investigate underlying mechanisms that could ultimately inform early diagnosis and treatments. Clinical studies are unable to dissociate the influence of maternal polypharmacy or the environment from direct effects of <em>in utero</em> opioid exposure, highlighting the need for effective animal models. Early animal models of prenatal opioid exposure primarily used the prototypical opioid, morphine, and opioid exposure that was often limited to a narrow period during gestation. In recent years, the number of preclinical studies has grown rapidly. Newer models utilize both prescription and nonprescription opioids and vary the onset and duration of opioid exposure. In this review, we summarize novel prenatal opioid exposure models developed in recent years and attempt to reconcile results between studies while critically identifying gaps within the current literature.</p>","PeriodicalId":23325,"journal":{"name":"Trends in Neurosciences","volume":"21 1","pages":""},"PeriodicalIF":15.9,"publicationDate":"2024-04-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140626021","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Advisory Board and Contents 咨询委员会和内容
IF 15.9 1区 医学
Trends in Neurosciences Pub Date : 2024-04-09 DOI: 10.1016/s0166-2236(24)00046-8
{"title":"Advisory Board and Contents","authors":"","doi":"10.1016/s0166-2236(24)00046-8","DOIUrl":"https://doi.org/10.1016/s0166-2236(24)00046-8","url":null,"abstract":"Abstract not available","PeriodicalId":23325,"journal":{"name":"Trends in Neurosciences","volume":"6 1","pages":""},"PeriodicalIF":15.9,"publicationDate":"2024-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140626028","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Subscription and Copyright Information 订阅和版权信息
IF 15.9 1区 医学
Trends in Neurosciences Pub Date : 2024-04-09 DOI: 10.1016/s0166-2236(24)00049-3
{"title":"Subscription and Copyright Information","authors":"","doi":"10.1016/s0166-2236(24)00049-3","DOIUrl":"https://doi.org/10.1016/s0166-2236(24)00049-3","url":null,"abstract":"Abstract not available","PeriodicalId":23325,"journal":{"name":"Trends in Neurosciences","volume":"54 1","pages":""},"PeriodicalIF":15.9,"publicationDate":"2024-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140626151","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
What does preferential viewing tell us about the neurobiology of recognition memory? 偏好观看对识别记忆的神经生物学有何启示？
IF 15.9 1区 医学
Trends in Neurosciences Pub Date : 2024-04-05 DOI: 10.1016/j.tins.2024.03.003
Benjamin M. Basile, Spencer J. Waters, Elisabeth A. Murray
{"title":"What does preferential viewing tell us about the neurobiology of recognition memory?","authors":"Benjamin M. Basile, Spencer J. Waters, Elisabeth A. Murray","doi":"10.1016/j.tins.2024.03.003","DOIUrl":"https://doi.org/10.1016/j.tins.2024.03.003","url":null,"abstract":"<p>The two tests most widely used in nonhuman primates to assess the neurobiology of recognition memory produce conflicting results. Preferential viewing tests (e.g., visual paired comparison) produce robust impairments following hippocampal lesions, whereas matching tests (e.g., delayed nonmatching-to-sample) often show complete sparing. Here, we review the data, the proposed explanations for this discrepancy, and then critically evaluate those explanations. The most likely explanation is that preferential viewing tests are not a process-pure assessment of recognition memory, but also test elements of novelty-seeking, habituation, and motivation. These confounds likely explain the conflicting results. Thus, we propose that memory researchers should prefer explicit matching tests and readers interested in the neural substrates of recognition memory should give explicit matching tests greater interpretive weight.</p>","PeriodicalId":23325,"journal":{"name":"Trends in Neurosciences","volume":"21 1","pages":""},"PeriodicalIF":15.9,"publicationDate":"2024-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140626026","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The neuronal cilium – a highly diverse and dynamic organelle involved in sensory detection and neuromodulation 神经元纤毛--一种高度多样化的动态细胞器，参与感觉检测和神经调节
IF 15.9 1区 医学
Trends in Neurosciences Pub Date : 2024-04-04 DOI: 10.1016/j.tins.2024.03.004
Nathalie Jurisch-Yaksi, Dagmar Wachten, Jay Gopalakrishnan
{"title":"The neuronal cilium – a highly diverse and dynamic organelle involved in sensory detection and neuromodulation","authors":"Nathalie Jurisch-Yaksi, Dagmar Wachten, Jay Gopalakrishnan","doi":"10.1016/j.tins.2024.03.004","DOIUrl":"https://doi.org/10.1016/j.tins.2024.03.004","url":null,"abstract":"<p>Cilia are fascinating organelles that act as cellular antennae, sensing the cellular environment. Cilia gained significant attention in the late 1990s after their dysfunction was linked to genetic diseases known as ciliopathies. Since then, several breakthrough discoveries have uncovered the mechanisms underlying cilia biogenesis and function. Like most cells in the animal kingdom, neurons also harbor cilia, which are enriched in neuromodulatory receptors. Yet, how neuronal cilia modulate neuronal physiology and animal behavior remains poorly understood. By comparing ciliary biology between the sensory and central nervous systems (CNS), we provide new perspectives on the functions of cilia in brain physiology.</p>","PeriodicalId":23325,"journal":{"name":"Trends in Neurosciences","volume":"17 1","pages":""},"PeriodicalIF":15.9,"publicationDate":"2024-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140626043","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Infant neuroscience: how to measure brain activity in the youngest minds 婴儿神经科学：如何测量最幼小心灵的大脑活动
IF 15.9 1区 医学
Trends in Neurosciences Pub Date : 2024-04-03 DOI: 10.1016/j.tins.2024.02.003
Nicholas B. Turk-Browne, Richard N. Aslin
{"title":"Infant neuroscience: how to measure brain activity in the youngest minds","authors":"Nicholas B. Turk-Browne, Richard N. Aslin","doi":"10.1016/j.tins.2024.02.003","DOIUrl":"https://doi.org/10.1016/j.tins.2024.02.003","url":null,"abstract":"<p>The functional properties of the infant brain are poorly understood. Recent advances in cognitive neuroscience are opening new avenues for measuring brain activity in human infants. These include novel uses of existing technologies such as electroencephalography (EEG) and magnetoencephalography (MEG), the availability of newer technologies including functional near-infrared spectroscopy (fNIRS) and optically pumped magnetometry (OPM), and innovative applications of functional magnetic resonance imaging (fMRI) in awake infants during cognitive tasks. In this review article we catalog these available non-invasive methods, discuss the challenges and opportunities encountered when applying them to human infants, and highlight the potential they may ultimately hold for advancing our understanding of the youngest minds.</p>","PeriodicalId":23325,"journal":{"name":"Trends in Neurosciences","volume":"123 1","pages":""},"PeriodicalIF":15.9,"publicationDate":"2024-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140626149","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Targeting the intracellular neurexin interactome by in vivo proximity ligation. 通过体内近距离连接瞄准细胞内神经毒素相互作用组。
IF 15.9 1区 医学
Trends in Neurosciences Pub Date : 2024-04-01 Epub Date: 2024-03-06 DOI: 10.1016/j.tins.2024.02.007
Ming-Han Wang, Yue Hao, Xia-Jing Tong
{"title":"Targeting the intracellular neurexin interactome by in vivo proximity ligation.","authors":"Ming-Han Wang, Yue Hao, Xia-Jing Tong","doi":"10.1016/j.tins.2024.02.007","DOIUrl":"10.1016/j.tins.2024.02.007","url":null,"abstract":"<p><p>In a recent study, Profes, Tiroumalechetty, and colleagues used the in vivo proximity ligation technique TurboID to scrupulously characterize the interactome of the intracellular domain (ICD) of neurexin, revealing that this domain may be involved in presynaptic actin assembly by interacting with actin-associated proteins.</p>","PeriodicalId":23325,"journal":{"name":"Trends in Neurosciences","volume":" ","pages":"243-245"},"PeriodicalIF":15.9,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140060638","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Embracing sleep-onset complexity. 迎接睡眠发病的复杂性。
IF 15.9 1区 医学
Trends in Neurosciences Pub Date : 2024-04-01 Epub Date: 2024-03-21 DOI: 10.1016/j.tins.2024.02.002
Célia Lacaux, Mélanie Strauss, Tristan A Bekinschtein, Delphine Oudiette
{"title":"Embracing sleep-onset complexity.","authors":"Célia Lacaux, Mélanie Strauss, Tristan A Bekinschtein, Delphine Oudiette","doi":"10.1016/j.tins.2024.02.002","DOIUrl":"10.1016/j.tins.2024.02.002","url":null,"abstract":"<p><p>Sleep is crucial for many vital functions and has been extensively studied. By contrast, the sleep-onset period (SOP), often portrayed as a mere prelude to sleep, has been largely overlooked and remains poorly characterized. Recent findings, however, have reignited interest in this transitional period and have shed light on its neural mechanisms, cognitive dynamics, and clinical implications. This review synthesizes the existing knowledge about the SOP in humans. We first examine the current definition of the SOP and its limits, and consider the dynamic and complex electrophysiological changes that accompany the descent to sleep. We then describe the interplay between internal and external processing during the wake-to-sleep transition. Finally, we discuss the putative cognitive benefits of the SOP and identify novel directions to better diagnose sleep-onset disorders.</p>","PeriodicalId":23325,"journal":{"name":"Trends in Neurosciences","volume":" ","pages":"273-288"},"PeriodicalIF":15.9,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140190178","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The emergence of multiscale connectomics-based approaches in stroke recovery. 基于多尺度连接组学的中风康复方法的出现。
IF 15.9 1区 医学
Trends in Neurosciences Pub Date : 2024-04-01 Epub Date: 2024-02-23 DOI: 10.1016/j.tins.2024.01.003
Shahrzad Latifi, S Thomas Carmichael
{"title":"The emergence of multiscale connectomics-based approaches in stroke recovery.","authors":"Shahrzad Latifi, S Thomas Carmichael","doi":"10.1016/j.tins.2024.01.003","DOIUrl":"10.1016/j.tins.2024.01.003","url":null,"abstract":"<p><p>Stroke is a leading cause of adult disability. Understanding stroke damage and recovery requires deciphering changes in complex brain networks across different spatiotemporal scales. While recent developments in brain readout technologies and progress in complex network modeling have revolutionized current understanding of the effects of stroke on brain networks at a macroscale, reorganization of smaller scale brain networks remains incompletely understood. In this review, we use a conceptual framework of graph theory to define brain networks from nano- to macroscales. Highlighting stroke-related brain connectivity studies at multiple scales, we argue that multiscale connectomics-based approaches may provide new routes to better evaluate brain structural and functional remapping after stroke and during recovery.</p>","PeriodicalId":23325,"journal":{"name":"Trends in Neurosciences","volume":" ","pages":"303-318"},"PeriodicalIF":15.9,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139944517","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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