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CK2-dependent SK channel dysfunction as contributor to neuronal hyperexcitability in Alzheimer's disease. ck2依赖性SK通道功能障碍是阿尔茨海默病中神经元高兴奋性的贡献者。
IF 15.1 1区 医学
Trends in Neurosciences Pub Date : 2025-02-01 Epub Date: 2025-01-04 DOI: 10.1016/j.tins.2024.12.006
Xiaojie Wei, Binggui Sun
{"title":"CK2-dependent SK channel dysfunction as contributor to neuronal hyperexcitability in Alzheimer's disease.","authors":"Xiaojie Wei, Binggui Sun","doi":"10.1016/j.tins.2024.12.006","DOIUrl":"10.1016/j.tins.2024.12.006","url":null,"abstract":"<p><p>Neuronal hyperexcitability in the cortex and hippocampus represents an early event in Alzheimer's disease (AD). In a recent study, Blankenship and colleagues reported that in a mouse of AD, ventral tegmental area (VTA) dopamine neurons are also hyperexcitable, and this hyperexcitability is due to casein kinase 2 (CK2)-dependent SK channel dysfunction, adding new insights into the underlying mechanisms of aberrant neuronal properties in AD.</p>","PeriodicalId":23325,"journal":{"name":"Trends in Neurosciences","volume":" ","pages":"98-99"},"PeriodicalIF":15.1,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142932789","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Coordinating the energetic strategy of glia and neurons for memory. 协调神经胶质细胞和神经元的能量策略。
IF 15.1 1区 医学
Trends in Neurosciences Pub Date : 2025-02-01 Epub Date: 2025-01-22 DOI: 10.1016/j.tins.2025.01.001
Hannah Shoenhard, Amita Sehgal
{"title":"Coordinating the energetic strategy of glia and neurons for memory.","authors":"Hannah Shoenhard, Amita Sehgal","doi":"10.1016/j.tins.2025.01.001","DOIUrl":"10.1016/j.tins.2025.01.001","url":null,"abstract":"<p><p>Memory consolidation requires rapid energy supply to neurons. In a recent study, Francés et al. revealed the signal by which a neuron commands glia to limit fatty acid synthesis in favor of metabolite export during memory formation in Drosophila melanogaster. This mechanism coordinates just-in-time glial energy delivery in response to dynamic neuronal needs.</p>","PeriodicalId":23325,"journal":{"name":"Trends in Neurosciences","volume":" ","pages":"93-95"},"PeriodicalIF":15.1,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11827068/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143029736","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Neocortical somatostatin neuron diversity in cognition and learning. 新皮质生长抑素神经元在认知和学习中的多样性。
IF 15.1 1区 医学
Trends in Neurosciences Pub Date : 2025-02-01 Epub Date: 2025-01-16 DOI: 10.1016/j.tins.2024.12.004
Eunsol Park, Matthew B Mosso, Alison L Barth
{"title":"Neocortical somatostatin neuron diversity in cognition and learning.","authors":"Eunsol Park, Matthew B Mosso, Alison L Barth","doi":"10.1016/j.tins.2024.12.004","DOIUrl":"10.1016/j.tins.2024.12.004","url":null,"abstract":"<p><p>Somatostatin-expressing (SST) neurons are a major class of electrophysiologically and morphologically distinct inhibitory cells in the mammalian neocortex. Transcriptomic data suggest that this class can be divided into multiple subtypes that are correlated with morpho-electric properties. At the same time, availability of transgenic tools to identify and record from SST neurons in awake, behaving mice has stimulated insights about their response properties and computational function. Neocortical SST neurons are regulated by sleep and arousal, attention, and novelty detection, and show marked response plasticity during learning. Recent studies suggest that subtype-specific analysis of SST neurons may be critical for understanding their complex roles in cortical function. In this review, we discuss and synthesize recent advances in understanding the diversity, circuit integration, and functional properties of this important group of GABAergic neurons.</p>","PeriodicalId":23325,"journal":{"name":"Trends in Neurosciences","volume":" ","pages":"140-155"},"PeriodicalIF":15.1,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143012340","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Establishing functionally segregated dopaminergic circuits. 建立功能分离的多巴胺能回路。
IF 15.1 1区 医学
Trends in Neurosciences Pub Date : 2025-02-01 Epub Date: 2025-01-24 DOI: 10.1016/j.tins.2024.12.002
Akiko Terauchi, Erin M Johnson-Venkatesh, Hisashi Umemori
{"title":"Establishing functionally segregated dopaminergic circuits.","authors":"Akiko Terauchi, Erin M Johnson-Venkatesh, Hisashi Umemori","doi":"10.1016/j.tins.2024.12.002","DOIUrl":"10.1016/j.tins.2024.12.002","url":null,"abstract":"<p><p>Despite accounting for only ~0.001% of all neurons in the human brain, midbrain dopaminergic neurons control numerous behaviors and are associated with many neuropsychiatric disorders that affect our physical and mental health. Dopaminergic neurons form various anatomically and functionally segregated pathways. Having such defined dopaminergic pathways is key to controlling varied sets of brain functions; therefore, segregated dopaminergic pathways must be properly and uniquely formed during development. How are these segregated pathways established? The three key developmental stages that dopaminergic neurons go through are cell migration, axon guidance, and synapse formation. In each stage, dopaminergic neurons and their processes receive unique molecular cues to guide the formation of specific dopaminergic pathways. Here, we outline the molecular mechanisms underlying the establishment of segregated dopaminergic pathways during each developmental stage in the mouse brain, focusing on the formation of the three major dopaminergic pathways: the nigrostriatal, mesolimbic, and mesocortical pathways. We propose that multiple stage-specific molecular gradients cooperate to establish functionally segregated dopaminergic circuits.</p>","PeriodicalId":23325,"journal":{"name":"Trends in Neurosciences","volume":" ","pages":"156-170"},"PeriodicalIF":15.1,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11951916/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143042311","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Peripheral, central, and chemotherapy-induced neuropathic changes in pancreatic cancer. 胰腺癌外周、中枢和化疗诱导的神经性改变。
IF 15.1 1区 医学
Trends in Neurosciences Pub Date : 2025-02-01 Epub Date: 2024-12-26 DOI: 10.1016/j.tins.2024.11.008
Luju Jiang, Shuqi Cai, Zheqi Weng, Shan Zhang, Shu-Heng Jiang
{"title":"Peripheral, central, and chemotherapy-induced neuropathic changes in pancreatic cancer.","authors":"Luju Jiang, Shuqi Cai, Zheqi Weng, Shan Zhang, Shu-Heng Jiang","doi":"10.1016/j.tins.2024.11.008","DOIUrl":"10.1016/j.tins.2024.11.008","url":null,"abstract":"<p><p>In pancreatic cancer, significant alterations occur in the local nervous system, including axonogenesis, neural remodeling, perineural invasion, and perineural neuritis. Pancreatic cancer can impact the central nervous system (CNS) through cancer cell-intrinsic factors or systemic factors, particularly in the context of cancer cachexia. These peripheral and central neuropathic changes exert substantial influence on cancer initiation and progression. Moreover, chemotherapy-induced neuropathy is common in pancreatic cancer, causing peripheral nerve damage and cognitive dysfunction. Targeting the crosstalk between pancreatic cancer and the nervous system, either peripherally or centrally, holds promise in cancer treatment, pain relief, and improved quality of life. Here, we summarize recent findings on the molecular mechanisms behind these neuropathic changes in pancreatic cancer and discuss potential intervention strategies.</p>","PeriodicalId":23325,"journal":{"name":"Trends in Neurosciences","volume":" ","pages":"124-139"},"PeriodicalIF":15.1,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142898368","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Origins of food selectivity in human visual cortex. 人类视觉皮层中食物选择性的起源。
IF 15.1 1区 医学
Trends in Neurosciences Pub Date : 2025-02-01 DOI: 10.1016/j.tins.2024.12.001
Margaret M Henderson, Michael J Tarr, Leila Wehbe
{"title":"Origins of food selectivity in human visual cortex.","authors":"Margaret M Henderson, Michael J Tarr, Leila Wehbe","doi":"10.1016/j.tins.2024.12.001","DOIUrl":"10.1016/j.tins.2024.12.001","url":null,"abstract":"<p><p>Several recent studies, enabled by advances in neuroimaging methods and large-scale datasets, have identified areas in human ventral visual cortex that respond more strongly to food images than to images of many other categories, adding to our knowledge about the broad network of regions that are responsive to food. This finding raises important questions about the evolutionary and developmental origins of a possible food-selective neural population, as well as larger questions about the origins of category-selective neural populations more generally. Here, we propose a framework for how visual properties of food (particularly color) and nonvisual signals associated with multimodal reward processing, social cognition, and physical interactions with food may, in combination, contribute to the emergence of food selectivity. We discuss recent research that sheds light on each of these factors, alongside a broader account of category selectivity that incorporates both visual feature statistics and behavioral relevance.</p>","PeriodicalId":23325,"journal":{"name":"Trends in Neurosciences","volume":" ","pages":"113-123"},"PeriodicalIF":15.1,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143075536","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Metacognition in the listening brain. 听觉大脑中的元认知。
IF 15.1 1区 医学
Trends in Neurosciences Pub Date : 2025-02-01 Epub Date: 2025-01-21 DOI: 10.1016/j.tins.2024.12.007
Jonas Obleser
{"title":"Metacognition in the listening brain.","authors":"Jonas Obleser","doi":"10.1016/j.tins.2024.12.007","DOIUrl":"10.1016/j.tins.2024.12.007","url":null,"abstract":"<p><p>How do you know you have heard right? Metacognition, the ability to assess and monitor one's own cognitive state, is key to understanding human communication in complex environments. However, the foundational role of metacognition in hearing and communication is only beginning to be explored, and the neuroscience behind it is an emerging field: how does confidence express in neural dynamics of the listening brain? What is known about auditory metaperceptual alterations as a hallmark phenomenon in psychosis, dementia, or hearing loss? Building on Bayesian ideas of auditory perception and auditory neuroscience, 'meta-listening' offers a framework for more comprehensive research into how metacognition in humans and non-humans shapes the listening brain.</p>","PeriodicalId":23325,"journal":{"name":"Trends in Neurosciences","volume":" ","pages":"100-112"},"PeriodicalIF":15.1,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143024892","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Advancing ALS research: public-private partnerships to accelerate drug and biomarker development. 推进 ALS 研究：公私合作加快药物和生物标记物的开发。
IF 15.1 1区 医学
Trends in Neurosciences Pub Date : 2025-01-01 Epub Date: 2024-11-21 DOI: 10.1016/j.tins.2024.10.008
Alessio Travaglia, Shubhangi Lal, Sri Ramulu Pullagura
{"title":"Advancing ALS research: public-private partnerships to accelerate drug and biomarker development.","authors":"Alessio Travaglia, Shubhangi Lal, Sri Ramulu Pullagura","doi":"10.1016/j.tins.2024.10.008","DOIUrl":"10.1016/j.tins.2024.10.008","url":null,"abstract":"<p><p>Developing effective treatments for amyotrophic lateral sclerosis (ALS) has been hindered by both the complexity of the disease and decentralized research efforts. By fostering collaboration, standardization, and inclusivity, the Accelerating Medicines Partnership® (AMP®) ALS initiative aims to lay the foundation for future discoveries in ALS biomarkers and treatments.</p>","PeriodicalId":23325,"journal":{"name":"Trends in Neurosciences","volume":" ","pages":"1-2"},"PeriodicalIF":15.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142693702","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cranial motor neuron input specificity refined by activity. 颅运动神经元输入特异性由活动细化。
IF 15.1 1区 医学
Trends in Neurosciences Pub Date : 2025-01-01 Epub Date: 2024-11-29 DOI: 10.1016/j.tins.2024.11.001
Kimberly L McArthur
{"title":"Cranial motor neuron input specificity refined by activity.","authors":"Kimberly L McArthur","doi":"10.1016/j.tins.2024.11.001","DOIUrl":"10.1016/j.tins.2024.11.001","url":null,"abstract":"<p><p>A recent study by Kaneko and colleagues provides evidence that developing cranial motor neurons in larval zebrafish refine their input specificity over time, using an activity-dependent mechanism that may depend, in part, on adaptive dendrite extension. These findings illuminate the mechanism by which spatially overlapping motor pools are recruited into distinct motor circuits.</p>","PeriodicalId":23325,"journal":{"name":"Trends in Neurosciences","volume":" ","pages":"5-6"},"PeriodicalIF":15.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142751826","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Where is the error? Hierarchical predictive coding through dendritic error computation: (Trends in Neurosciences 46, 45-59; 2023). 错误在哪里？基于树突误差计算的分层预测编码[j]；2023)。
IF 14.6 1区 医学
Trends in Neurosciences Pub Date : 2025-01-01 Epub Date: 2024-12-05 DOI: 10.1016/j.tins.2024.11.002
Fabian A Mikulasch, Lucas Rudelt, Michael Wibral, Viola Priesemann
{"title":"Where is the error? Hierarchical predictive coding through dendritic error computation: (Trends in Neurosciences 46, 45-59; 2023).","authors":"Fabian A Mikulasch, Lucas Rudelt, Michael Wibral, Viola Priesemann","doi":"10.1016/j.tins.2024.11.002","DOIUrl":"10.1016/j.tins.2024.11.002","url":null,"abstract":"","PeriodicalId":23325,"journal":{"name":"Trends in Neurosciences","volume":" ","pages":"92"},"PeriodicalIF":14.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142792594","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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