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Trends in Neurosciences最新文献

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Neuroimaging of opioid effects in humans across conditions of acute administration, chronic pain therapy, and opioid use disorder. 阿片类药物在急性用药、慢性疼痛治疗和阿片类药物使用障碍等情况下对人体影响的神经影像学研究。
IF 15.9 1区 医学
Trends in Neurosciences Pub Date : 2024-06-01 Epub Date: 2024-05-17 DOI: 10.1016/j.tins.2024.04.005
Katherine T Martucci
{"title":"Neuroimaging of opioid effects in humans across conditions of acute administration, chronic pain therapy, and opioid use disorder.","authors":"Katherine T Martucci","doi":"10.1016/j.tins.2024.04.005","DOIUrl":"10.1016/j.tins.2024.04.005","url":null,"abstract":"<p><p>Evidence of central nervous system (CNS) exogenous opioid effects in humans has been primarily gained through neuroimaging of three participant populations: individuals after acute opioid administration, those with opioid use disorder (OUD), and those with chronic pain receiving opioid therapy. In both the brain and spinal cord, opioids alter processes of pain, cognition, and reward. Opioid-related CNS effects may persist and accumulate with longer opioid use duration. Meanwhile, opioid-induced benefits versus risks to brain health remain unclear. This review article highlights recent accumulating evidence for how exogenous opioids impact the CNS in humans. While investigation of CNS opioid effects has remained largely disparate across contexts of opioid acute administration, OUD, and chronic pain opioid therapy, integration across these contexts may enable advancement toward effective interventions.</p>","PeriodicalId":23325,"journal":{"name":"Trends in Neurosciences","volume":" ","pages":"418-431"},"PeriodicalIF":15.9,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11168870/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140959631","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Mechanisms and implications of gamma oscillation plasticity. 伽马振荡可塑性的机制和影响。
IF 15.9 1区 医学
Trends in Neurosciences Pub Date : 2024-06-01 Epub Date: 2024-05-16 DOI: 10.1016/j.tins.2024.05.002
Michael T Craig, Monika H Bielska, Kate Jeffery
{"title":"Mechanisms and implications of gamma oscillation plasticity.","authors":"Michael T Craig, Monika H Bielska, Kate Jeffery","doi":"10.1016/j.tins.2024.05.002","DOIUrl":"10.1016/j.tins.2024.05.002","url":null,"abstract":"<p><p>A recent study by Hadler and colleagues uncovered a novel form of plasticity of gamma oscillations in an ex vivo hippocampal slice preparation which they term 'gamma potentiation'. We discuss the potential cellular mechanisms of this form of plasticity and its functional and translational implications.</p>","PeriodicalId":23325,"journal":{"name":"Trends in Neurosciences","volume":" ","pages":"398-399"},"PeriodicalIF":15.9,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140959630","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Contextualized hippocampal-cortical dynamics underlying traumatic memory. 创伤记忆所依赖的海马-皮层动态内涵。
IF 15.9 1区 医学
Trends in Neurosciences Pub Date : 2024-06-01 Epub Date: 2024-05-20 DOI: 10.1016/j.tins.2024.04.009
Ruth A Lanius, Breanne E Kearney
{"title":"Contextualized hippocampal-cortical dynamics underlying traumatic memory.","authors":"Ruth A Lanius, Breanne E Kearney","doi":"10.1016/j.tins.2024.04.009","DOIUrl":"10.1016/j.tins.2024.04.009","url":null,"abstract":"<p><p>In a recent study, Clancy et al. elucidate a connection between activity patterns of the hippocampus (HC) and the broader functional connectivity networks associated with trauma-related intrusive memories (TR-IMs). This neurophenomenological methodology situates the HC within a larger neural framework and provides a nuanced exploration of the neurobiological underpinnings of distinct characteristics of TR-IMs.</p>","PeriodicalId":23325,"journal":{"name":"Trends in Neurosciences","volume":" ","pages":"400-401"},"PeriodicalIF":15.9,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141076884","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Physical exercise, cognition, and brain health in aging. 体育锻炼、认知和老年期大脑健康。
IF 15.9 1区 医学
Trends in Neurosciences Pub Date : 2024-06-01 Epub Date: 2024-05-28 DOI: 10.1016/j.tins.2024.04.004
Nárlon C Boa Sorte Silva, Cindy K Barha, Kirk I Erickson, Arthur F Kramer, Teresa Liu-Ambrose
{"title":"Physical exercise, cognition, and brain health in aging.","authors":"Nárlon C Boa Sorte Silva, Cindy K Barha, Kirk I Erickson, Arthur F Kramer, Teresa Liu-Ambrose","doi":"10.1016/j.tins.2024.04.004","DOIUrl":"10.1016/j.tins.2024.04.004","url":null,"abstract":"<p><p>Exercise training is an important strategy to counteract cognitive and brain health decline during aging. Evidence from systematic reviews and meta-analyses supports the notion of beneficial effects of exercise in cognitively unimpaired and impaired older individuals. However, the effects are often modest, and likely influenced by moderators such as exercise training parameters, sample characteristics, outcome assessments, and control conditions. Here, we discuss evidence on the impact of exercise on cognitive and brain health outcomes in healthy aging and in individuals with or at risk for cognitive impairment and neurodegeneration. We also review neuroplastic adaptations in response to exercise and their potential neurobiological mechanisms. We conclude by highlighting goals for future studies, including addressing unexplored neurobiological mechanisms and the inclusion of under-represented populations.</p>","PeriodicalId":23325,"journal":{"name":"Trends in Neurosciences","volume":" ","pages":"402-417"},"PeriodicalIF":15.9,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141176507","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Putting the brakes on axonal branching. 为轴突分支踩刹车
IF 15.9 1区 医学
Trends in Neurosciences Pub Date : 2024-05-16 DOI: 10.1016/j.tins.2024.05.001
Ismael Ferrer, Chadni Sanyal, Marie-Jo Moutin, Damaris N Lorenzo
{"title":"Putting the brakes on axonal branching.","authors":"Ismael Ferrer, Chadni Sanyal, Marie-Jo Moutin, Damaris N Lorenzo","doi":"10.1016/j.tins.2024.05.001","DOIUrl":"https://doi.org/10.1016/j.tins.2024.05.001","url":null,"abstract":"<p><p>In a recent study, Ziak et al. employed precise sparse labeling and spatiotemporally controlled genetic manipulations to uncover novel regulators of axon branching of layer 2/3 mouse callosal projection neurons. The authors elucidated a cell-autonomous signaling pathway wherein glycogen synthase kinase 3β (GSK3β) phosphorylation of microtubule-associated protein 1B (MAP1B) restricts interstitial axon branching by modulating microtubule (MT) tyrosination status.</p>","PeriodicalId":23325,"journal":{"name":"Trends in Neurosciences","volume":" ","pages":""},"PeriodicalIF":15.9,"publicationDate":"2024-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140959632","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The ‘in’s and out’s’ of descending pain modulation from the rostral ventromedial medulla 喙腹内侧延髓降序疼痛调节的 "进与退
IF 15.9 1区 医学
Trends in Neurosciences Pub Date : 2024-05-14 DOI: 10.1016/j.tins.2024.04.006
Caitlynn C. De Preter, Mary M. Heinricher
{"title":"The ‘in’s and out’s’ of descending pain modulation from the rostral ventromedial medulla","authors":"Caitlynn C. De Preter, Mary M. Heinricher","doi":"10.1016/j.tins.2024.04.006","DOIUrl":"https://doi.org/10.1016/j.tins.2024.04.006","url":null,"abstract":"<p>The descending-pain modulating circuit controls the experience of pain by modulating transmission of sensory signals through the dorsal horn. This circuit’s key output node, the rostral ventromedial medulla (RVM), integrates ‘top-down’ and ‘bottom-up’ inputs that regulate functionally defined RVM cell types, ‘OFF-cells’ and ‘ON-cells’, which respectively suppress or facilitate pain-related sensory processing. While recent advances have sought molecular definition of RVM cell types, conflicting behavioral findings highlight challenges involved in aligning functional and molecularly defined types. This review summarizes current understanding, derived primarily from rodent studies but with corroborating evidence from human imaging, of the role of RVM populations in pain modulation and persistent pain states and explores recent advances outlining inputs to, and outputs from, RVM pain-modulating neurons.</p>","PeriodicalId":23325,"journal":{"name":"Trends in Neurosciences","volume":"43 1","pages":""},"PeriodicalIF":15.9,"publicationDate":"2024-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140932541","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Advisory Board and Contents 咨询委员会和内容
IF 15.9 1区 医学
Trends in Neurosciences Pub Date : 2024-05-14 DOI: 10.1016/s0166-2236(24)00068-7
{"title":"Advisory Board and Contents","authors":"","doi":"10.1016/s0166-2236(24)00068-7","DOIUrl":"https://doi.org/10.1016/s0166-2236(24)00068-7","url":null,"abstract":"No Abstract","PeriodicalId":23325,"journal":{"name":"Trends in Neurosciences","volume":"38 1","pages":""},"PeriodicalIF":15.9,"publicationDate":"2024-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140932117","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Subscription and Copyright Information 订阅和版权信息
IF 15.9 1区 医学
Trends in Neurosciences Pub Date : 2024-05-14 DOI: 10.1016/s0166-2236(24)00071-7
{"title":"Subscription and Copyright Information","authors":"","doi":"10.1016/s0166-2236(24)00071-7","DOIUrl":"https://doi.org/10.1016/s0166-2236(24)00071-7","url":null,"abstract":"No Abstract","PeriodicalId":23325,"journal":{"name":"Trends in Neurosciences","volume":"66 1","pages":""},"PeriodicalIF":15.9,"publicationDate":"2024-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140932466","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Neurobiological basis of emergence from anesthesia. 麻醉苏醒的神经生物学基础。
IF 15.9 1区 医学
Trends in Neurosciences Pub Date : 2024-05-01 Epub Date: 2024-03-14 DOI: 10.1016/j.tins.2024.02.006
Xue-Jun Song, Jiang-Jian Hu
{"title":"Neurobiological basis of emergence from anesthesia.","authors":"Xue-Jun Song, Jiang-Jian Hu","doi":"10.1016/j.tins.2024.02.006","DOIUrl":"10.1016/j.tins.2024.02.006","url":null,"abstract":"<p><p>The suppression of consciousness by anesthetics and the emergence of the brain from anesthesia are complex and elusive processes. Anesthetics may exert their inhibitory effects by binding to specific protein targets or through membrane-mediated targets, disrupting neural activity and the integrity and function of neural circuits responsible for signal transmission and conscious perception/subjective experience. Emergence from anesthesia was generally thought to depend on the elimination of the anesthetic from the body. Recently, studies have suggested that emergence from anesthesia is a dynamic and active process that can be partially controlled and is independent of the specific molecular targets of anesthetics. This article summarizes the fundamentals of anesthetics' actions in the brain and the mechanisms of emergence from anesthesia that have been recently revealed in animal studies.</p>","PeriodicalId":23325,"journal":{"name":"Trends in Neurosciences","volume":" ","pages":"355-366"},"PeriodicalIF":15.9,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140137276","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
CRISPR-based identification of N-terminal acetylation in synucleinopathies. 基于 CRISPR 的突触核蛋白病 N 端乙酰化鉴定。
IF 15.9 1区 医学
Trends in Neurosciences Pub Date : 2024-05-01 Epub Date: 2024-03-28 DOI: 10.1016/j.tins.2024.03.006
Eun-Jin Bae, Seung-Jae Lee
{"title":"CRISPR-based identification of N-terminal acetylation in synucleinopathies.","authors":"Eun-Jin Bae, Seung-Jae Lee","doi":"10.1016/j.tins.2024.03.006","DOIUrl":"10.1016/j.tins.2024.03.006","url":null,"abstract":"<p><p>A recent study by Kumar et al. identified several biological pathways that regulate the levels of endogenous alpha-synuclein (α-synuclein). They specifically highlighted the N-terminal acetylation (NTA) pathway as an important factor in maintaining the stability of endogenous α-synuclein, suggesting targeting the NTA pathway as a potential therapeutic approach.</p>","PeriodicalId":23325,"journal":{"name":"Trends in Neurosciences","volume":" ","pages":"324-325"},"PeriodicalIF":15.9,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140327202","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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