Digestive exophagy as a novel mechanism of amyloid-β degradation by microglial lysosomes.

IF 14.6 1区医学 Q1 NEUROSCIENCES

Trends in Neurosciences Pub Date : 2025-03-01 Epub Date: 2025-02-13 DOI:10.1016/j.tins.2025.01.005

Melanie Meyer-Luehmann

引用次数: 0

Abstract

Microglia are known to be involved in the modulation of amyloid-β (Aβ) plaques in Alzheimer's disease (AD). In a recent study, Jacquet et al. describe how microglia degrade larger Aβ aggregates by forming lysosomal synapses, further implicating the microglial release of lysosomal Aβ, amongst other processes, in the growth and spread of fibrillary Aβ.

查看原文本刊更多论文

众所周知，小胶质细胞参与了阿尔茨海默病（AD）中淀粉样蛋白-β（Aβ）斑块的调节。在最近的一项研究中，Jacquet 等人描述了小胶质细胞如何通过形成溶酶体突触来降解较大的 Aβ 聚集体，并进一步指出小胶质细胞释放溶酶体 Aβ 以及其他过程与纤维状 Aβ 的生长和扩散有关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Trends in Neurosciences 医学-神经科学

CiteScore

26.50

自引率

1.30%

发文量

123

审稿时长

6-12 weeks

期刊介绍： For over four decades, Trends in Neurosciences (TINS) has been a prominent source of inspiring reviews and commentaries across all disciplines of neuroscience. TINS is a monthly, peer-reviewed journal, and its articles are curated by the Editor and authored by leading researchers in their respective fields. The journal communicates exciting advances in brain research, serves as a voice for the global neuroscience community, and highlights the contribution of neuroscientific research to medicine and society.