评估活体啮齿动物大脑中多巴胺系统激活的全脑结果。

IF 14.6 1区医学 Q1 NEUROSCIENCES

Trends in Neurosciences Pub Date : 2024-12-24 DOI:10.1016/j.tins.2024.12.003

Christian Limberger, Eduardo R Zimmer

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引用次数: 0

摘要

在最近的一项研究中，哈斯、布拉沃及其同事将光遗传刺激与大鼠体内正电子发射断层扫描（PET）/磁共振成像（MRI）同步功能测量结合起来。通过激活黑质(SNc)的黑质通路，他们在全脑水平上观察到了活体动物体内与多巴胺能通路相关的代谢和血液动力学波动。

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Assessing brain-wide outcomes of dopamine system activation in the living rodent brain.

In a recent study, Haas, Bravo, and colleagues integrated optogenetic stimulation with simultaneous functional in vivo positron emission tomography (PET)/magnetic resonance imaging (MRI) measurements in rats. By activating the nigrostriatal pathway in the substantia nigra pars compacta (SNc), they observed concurrent metabolic and hemodynamic fluctuations associated with the dopaminergic pathway in living animals at the whole-brain level.

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来源期刊

Trends in Neurosciences 医学-神经科学

CiteScore

26.50

自引率

1.30%

发文量

123

审稿时长

6-12 weeks

期刊介绍： For over four decades, Trends in Neurosciences (TINS) has been a prominent source of inspiring reviews and commentaries across all disciplines of neuroscience. TINS is a monthly, peer-reviewed journal, and its articles are curated by the Editor and authored by leading researchers in their respective fields. The journal communicates exciting advances in brain research, serves as a voice for the global neuroscience community, and highlights the contribution of neuroscientific research to medicine and society.